Hub : Genes

INTU

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.324 0.071 4.1e-11 0.345 NA 0.295 NA 0.011 4.6e-16 NA 1.4e-13 NA 0.098
2 GTEx Thyroid 0.046 0.024 2.8e-03 0.003 NA 0.026 NA 0.011 1.8e-01 NA 4.1e-03 NA 0.046

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.2 2.0 3.9 -0.1 -2.0
Bipolar Disorder or Schizophrenia 0.3 0.8 1.4 0.3 -1.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.3 0.3 -0.6
Depression (Nagel 2018) 0.0 0.0 0.1 0.1 0.3
Intelligence (Savage-Jansen 2018) 0.0 0.2 0.3 0.6 -0.0
Neuroticism (Nagel 2018) 0.2 0.4 0.4 0.6 -0.6
Schizophrenia (2018) 0.0 0.1 0.2 0.4 0.0
Schizophrenia vs Biploar Disorder 0.6 0.9 1.3 1.1 -0.6
Worry (Nagel 2018) 1.0 2.0 3.5 1.9 -0.7
Alzheimer’s Disease (in mother) 0.4 0.5 0.8 0.9 -0.4
Alzheimer’s Disease (in father) 4.7 5.1 9.4 -3.1 0.9
Alzheimer’s Disease (including proxy) 0.7 1.1 1.9 -1.4 0.5
Crohns Disease (2017) 0.7 1.4 2.4 -0.7 1.6
Irritable Bowel Disease (IBD) 0.1 0.2 0.2 0.4 0.4
Ulcerative Colitis (UC) 0.3 0.7 0.8 0.9 -0.7
Major Depression (MDD) 2.5 3.0 5.9 0.3 2.4
Reaction Time 0.1 0.2 0.3 -0.2 0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.8 -0.1 0.9
Breast Cancer 2.0 4.8 8.8 3.0 -0.9
Ovarian Cancer 0.0 0.0 0.0 0.1 0.2
Prostate Cancer 0.7 1.0 1.7 -1.3 0.5
Age at First Birth 1.6 2.3 2.7 1.4 -1.6
Bipolar Disorder (2011) 1.4 1.4 2.5 0.5 -1.6
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 0.1 -0.2
Coronary Artery Disease (CAD) 1.3 1.6 2.0 -1.1 1.4
Crohns Disease (2012) 0.0 0.1 0.1 0.1 0.4
Mean Putamen Volume 1.8 2.0 4.0 -2.0 0.1
Fasting Glucose 1.2 1.4 2.7 -0.4 1.7
HbA1C 0.5 0.5 1.1 -1.0 -0.2
HDL Cholesterol 0.2 0.4 0.7 -0.2 -0.8
LDL Cholesterol 1.3 2.1 3.3 -1.8 0.9
Lupus 0.2 0.3 0.6 0.7 -0.2
Neuroticism (2016) 0.5 0.8 0.8 0.9 -0.8
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.7 -0.4
Rheumatoid Arthritis 1.6 2.2 3.6 1.9 -0.9
Schizophrenia (2014) 0.2 0.5 0.8 0.3 -0.9
Triglycerides 2.0 3.3 3.3 -1.8 1.8
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 0.2 0.3
Ulcerative Colitis 0.1 0.2 0.3 0.6 -0.0
Blood Eosinophil Count 0.0 0.0 0.0 -0.2 0.2
Blood Platelet Count 1.0 11.7 14.4 -3.0 3.8
Blood Red Count 0.2 1.8 2.3 -1.5 -1.1
Blood White Count 0.1 0.4 0.8 -0.9 -0.1
Heel T-Score 0.2 2.0 3.8 0.3 -2.0
BMI 0.0 0.2 0.2 -0.4 0.4
Height 0.1 1.3 2.5 -0.5 1.6
Waist Hip Ratio (WHR) 0.3 1.5 2.3 1.5 0.8
Systolic Blood Pressure 0.6 3.0 5.9 -0.3 2.4
Smoking Status 0.1 0.3 0.5 0.3 -0.7
Allergy or Eczema 0.2 0.5 0.9 -0.3 1.0
Cardiovascular Disease 0.9 3.1 6.1 -0.4 2.5
Hypothyroidism (self reported) 0.0 0.1 0.2 -0.4 -0.0
Respiratory disease 0.0 0.1 0.1 0.3 0.3
Type 2 Diabetes (T2D) (2018) 2.2 4.1 6.4 -1.4 2.5
Lung FEV1/FVC ratio 0.0 0.2 0.3 0.6 0.4
Lung FVC 4.3 21.7 35.4 6.0 -2.8
Neuroticism 0.2 0.5 0.6 0.6 -0.8
Chronotype (morning person) 0.3 0.7 0.8 0.9 -0.7
Hair Pigment 0.0 0.4 0.7 -0.8 0.1
Tanning 0.0 0.1 0.2 0.5 0.2
Hand grip strength (left) 0.5 1.4 1.5 1.1 -1.2
Number of treatments/medications taken 0.6 1.1 1.9 0.5 -1.4
Average weekly spirits intake 0.3 0.4 0.7 -0.2 0.8
Sensitivity / hurt feelings 0.6 1.1 1.8 1.3 -0.7
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.9 0.0 -1.0
Hearing difficulty/problems: Yes 2.8 4.2 6.2 -1.5 2.5
Relative age of first facial hair 1.4 2.8 3.5 1.4 -1.9
Other serious medical condition/disability diagnosed by doctor 1.0 1.4 2.2 -0.7 1.5
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 -0.0 0.4
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 -0.4 0.2
Systolic blood pressure, automated reading 0.1 0.2 0.3 -0.3 -0.6
Eye problems/disorders: Diabetes related eye disease 1.7 1.8 3.3 -1.8 0.6
Angina 0.3 0.4 0.7 -0.8 0.4
Medication for hormone replacement therapy 0.8 0.9 1.8 -1.3 0.0
Vitamin and mineral supplements 0.2 0.3 0.5 0.3 0.7
Supplements: Zinc 2.2 2.4 4.8 -2.2 0.1
Medication: Co-codamol 0.0 0.0 0.0 0.2 -0.2
Medication: Metformin 2.3 3.2 5.5 -1.0 2.3
Diabetes (father) 0.4 0.5 0.5 0.7 0.7
Diabetes (mother) 0.8 1.0 1.5 -1.2 0.7
Severe depression (siblings) 1.0 1.2 2.3 -0.1 1.5
Pack years adult smoking proportion 0.1 0.1 0.1 -0.4 0.3
Impedance of leg (right) 0.2 0.8 1.5 1.2 -0.0
Leg fat-free mass (left) 0.3 1.6 2.5 -1.6 0.9
Trunk fat percentage 0.0 0.0 0.0 -0.2 -0.2
Hand grip strength (right) 0.4 1.1 1.7 1.3 -0.6
Townsend deprivation index at recruitment 1.3 1.8 2.7 -1.6 1.0
Current tobacco smoking 0.0 0.0 0.0 0.1 0.0
Average weekly fortified wine intake 0.1 0.1 0.1 0.3 0.2
Maternal smoking around birth 0.5 0.7 1.3 1.2 0.2
Fed-up feelings 0.6 1.1 1.7 -0.6 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.5 -0.2
Relative age voice broke 0.3 0.5 0.7 0.6 -0.9
Taking other prescription medications 0.0 0.0 0.0 -0.0 -0.2
Age when periods started (menarche) 0.2 0.4 0.6 -0.8 -0.4
Bilateral oophorectomy (both ovaries removed) 2.6 3.0 3.9 2.0 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.1 -0.9 -1.1
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 0.1 -0.2
Qualifications: CSEs or equivalent 0.1 0.1 0.1 0.3 -0.3
Serious illness, injury or assault to yourself 0.6 0.7 0.9 -0.9 0.7
High blood pressure 0.7 1.8 1.9 -1.4 1.3
Hayfever, allergic rhinitis or eczema 0.6 1.4 1.7 -1.0 1.3
Multivitamins +/- minerals 0.6 0.8 1.2 -0.6 -1.1
Stomach or abdominal pain in last month 0.1 0.1 0.1 -0.3 -0.4
Supplements: Glucosamine 1.4 1.8 2.3 -1.5 1.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.1 0.5 1.4
Medication: Atenolol 1.3 1.6 2.0 -1.4 1.1
Medication: Levothyroxine sodium 0.0 0.0 0.1 -0.0 0.3
Sitting height 0.4 2.6 4.8 -0.6 2.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.2 -0.5
High blood pressure (mother) 0.5 0.7 1.0 -0.7 1.0
Body mass index (BMI) 0.1 0.2 0.5 -0.7 -0.1
Impedance of leg (left) 0.1 0.3 0.6 0.8 -0.1
Leg predicted mass (left) 0.3 1.5 2.3 -1.5 0.8
Trunk fat mass 0.0 0.2 0.2 -0.5 0.4
Waist circumference 0.4 1.5 2.0 -1.0 1.4
Number of incorrect matches in round 1.1 1.8 2.0 -1.2 -1.4
Past tobacco smoking 0.4 0.8 1.5 -0.3 1.2
Alcohol usually taken with meals 0.6 1.0 1.7 -0.6 1.3
Nervous feelings 1.1 2.1 2.2 1.4 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.9 -0.9 -0.4
Hearing difficulty/problems with background noise 3.0 4.9 5.1 -2.1 2.3
Hair/balding pattern: Pattern 2 0.7 0.8 1.2 0.7 1.1
Had menopause 0.1 0.1 0.1 0.3 0.3
Had other major operations 0.2 0.2 0.4 0.7 -0.1
Forced vital capacity (FVC) 0.9 3.5 6.9 2.6 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.2 -0.9 -1.1
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 1.9 0.8 1.4
Qualifications: None of the above 1.5 3.2 6.3 0.3 -2.5
Financial difficulties in last 2 years 0.1 0.1 0.1 -0.4 0.3
Mouth/teeth dental problems 0.9 1.3 2.3 1.5 -0.6
Heart attack 0.3 0.3 0.7 -0.1 -0.8
Allergy 0.6 1.3 1.8 1.3 -0.9
Pain all over the body in last month 0.6 0.7 1.3 -1.1 -0.2
Diabetes (self-reported) 2.2 3.3 4.6 -2.2 1.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.3 0.0 1.2
Medication: Ramipril 0.7 0.9 1.7 -1.3 0.0
Medication: Simvastatin 0.1 0.2 0.4 -0.2 0.6
Fluid intelligence score 0.3 0.7 1.4 0.1 1.2
Illnesses of siblings 0.2 0.3 0.4 -0.6 0.5
Neuroticism score 0.2 0.5 1.0 0.1 -1.0
Weight 0.1 0.7 1.0 -1.0 0.6
Impedance of arm (right) 0.2 0.9 1.2 1.1 -0.7
Arm fat percentage (right) 0.0 0.1 0.2 -0.4 -0.1
Trunk fat-free mass 0.3 1.8 2.0 -1.4 1.2
Hip circumference 0.4 1.7 2.9 -1.7 0.6
Time employed in main current job 0.4 0.5 0.5 0.7 -0.7
Alcohol intake versus 10 years previously 0.4 0.5 1.1 0.1 1.0
Father’s age at death 0.4 0.6 0.6 -0.7 -0.8
Worrier / anxious feelings 0.9 1.6 2.8 1.7 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.5 -1.2 0.4
Falls in the last year 2.0 2.7 4.2 -1.1 2.0
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 0.5 0.3
Number of live births 0.3 0.5 1.0 0.1 1.0
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 8.6 2.9 -0.1
Pulse rate 3.1 5.2 9.1 -1.2 3.0
Happiness 3.1 3.8 7.5 -2.7 0.4
Noisy workplace 0.9 1.1 2.1 1.5 -0.2
Qualifications: A levels/AS levels or equivalent 3.9 8.6 12.9 -2.1 3.6
Serious illness, injury or assault of a close relative in last 2 years 5.1 5.9 6.5 -2.6 2.3
Mouth/teeth dental problems: Dentures 0.5 0.9 1.6 -1.3 -0.4
Asthma 0.1 0.1 0.3 -0.1 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.1 0.4
Medication: Cholesterol lowering 0.5 0.8 1.6 1.3 -0.2
Depression (self-reported) 0.6 0.8 1.5 -1.2 -0.1
Medication: Lansoprazole 1.4 1.6 3.0 1.7 -0.4
Prospective memory result 1.2 1.5 2.7 -0.5 -1.6
Lung cancer (father) 0.3 0.4 0.8 0.9 0.2
Illnesses of mother 0.2 0.3 0.5 -0.0 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.9 9.9 3.1 -0.0
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.1 0.1
Impedance of arm (left) 0.5 2.2 3.5 1.9 -0.9
Arm fat mass (right) 0.1 0.4 0.8 -0.9 0.2
Trunk predicted mass 0.3 1.7 1.9 -1.4 1.2
Standing height 0.1 0.9 1.6 -0.4 1.3
Length of working week for main job 0.2 0.2 0.4 0.2 -0.6
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.5 0.1
Breastfed as a baby 0.0 0.1 0.1 -0.3 -0.2
Tense / ‘highly strung’ 0.2 0.3 0.5 -0.7 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.3 1.1 -0.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.2 0.4 -0.4
Birth weight of first child 0.3 0.6 1.0 1.0 0.4
Peak expiratory flow (PEF) 0.1 0.2 0.2 0.5 -0.3
Pulse wave reflection index 0.5 0.6 0.6 0.7 -0.8
Ever highly irritable/argumentative for 2 days 0.5 0.6 0.8 -0.9 0.7
Loud music exposure frequency 0.2 0.2 0.3 0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 5.4 -0.7 2.3
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 2.6 -1.6 0.9
Blood clot in the leg (DVT) 0.5 0.7 1.2 -1.1 0.4
Medication: Paracetamol 0.3 0.4 0.7 0.4 -0.8
Headache pain in last month 0.7 1.3 2.1 0.6 -1.5
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.2 -0.2
Glaucoma (self-reported) 0.4 0.4 0.5 0.6 -0.7
Gout (self-reported) 0.6 0.8 1.6 -1.2 -0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.6 -0.8 0.1
Medication: Amlodipine 0.4 0.6 1.1 1.0 -0.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.6 0.7 -0.8
Birth weight 0.1 0.3 0.6 0.7 -0.0
Chronic bronchitis/emphysema (mother) 0.6 0.6 1.2 -1.1 0.3
High blood pressure (siblings) 0.1 0.1 0.2 0.5 -0.0
Forced vital capacity (FVC), Best measure 1.1 3.9 7.7 2.8 -0.2
Body fat percentage 0.0 0.1 0.1 -0.3 -0.2
Leg fat percentage (right) 0.1 0.4 0.8 -0.9 0.3
Arm fat-free mass (right) 0.4 2.2 2.7 -1.7 1.3
Exposure to tobacco smoke outside home 0.3 0.3 0.7 -0.1 0.8
Comparative body size at age 10 0.0 0.0 0.1 -0.1 -0.3
Number of full brothers 0.1 0.1 0.1 -0.3 0.2
Worry too long after embarrassment 0.2 0.3 0.4 -0.6 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.3 0.1
Wheeze or whistling in the chest in last year 2.1 3.7 7.1 -2.7 0.6
Number of children fathered 0.1 0.2 0.3 0.1 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.7 0.7 -0.9
Age at first live birth 0.1 0.3 0.3 0.6 0.4
Pulse wave peak to peak time 0.0 0.0 0.0 -0.2 0.1
Health satisfaction 0.6 0.8 1.7 -1.3 0.0
Shortness of breath walking on level ground 0.6 0.7 0.7 -0.8 -0.8
Qualifications: College or University degree 1.0 3.0 3.6 -1.6 1.9
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.1 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 -0.8 0.1
Emphysema/chronic bronchitis 2.8 3.1 3.5 -1.9 1.6
Medication for pain relief, constipation, heartburn 0.2 0.4 0.7 -0.8 -0.2
Neck or shoulder pain in last month 0.1 0.2 0.3 -0.3 0.5
Medication: Blood pressure 1.3 2.2 3.3 -1.1 1.8
Angina (self-reported) 0.2 0.2 0.4 -0.7 0.2
Migraine (self-reported) 0.1 0.1 0.2 0.3 -0.4
Medication: Ibuprofen 0.4 0.5 0.8 -0.4 0.9
Medication: Allopurinol 0.8 1.0 1.9 -1.4 -0.4
Medication: Omeprazole 2.8 3.3 5.7 2.4 -1.0
Medication: Seretide 50 evohaler 0.1 0.1 0.2 -0.5 0.2
Mean time to correctly identify matches 0.0 0.0 0.0 0.0 0.2
Heart disease (mother) 0.8 0.9 1.8 1.3 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 3.6 -1.9 0.1
Whole body fat mass 0.1 0.3 0.6 -0.8 0.2
Leg fat mass (right) 0.2 0.6 1.0 -1.0 0.5
Arm predicted mass (right) 0.5 2.5 3.2 -1.8 1.3
Pulse rate, automated reading 1.3 4.2 7.3 -1.1 2.7
Alcohol intake frequency. 0.3 0.6 0.7 -0.7 -0.8
Comparative height size at age 10 0.3 1.5 2.7 0.5 1.6
Number of full sisters 0.1 0.1 0.2 -0.4 -0.1
Suffer from ‘nerves’ 0.8 1.3 2.1 0.7 -1.4
Overall health rating 0.9 1.9 3.4 -1.8 0.7
Chest pain or discomfort 0.2 0.4 0.7 -0.8 0.2
Had major operations 0.3 0.3 0.3 -0.6 -0.5
Age at last live birth 0.9 1.2 2.5 0.0 1.6
Family relationship satisfaction 1.8 2.2 3.8 -2.0 0.7
Leg pain on walking 0.5 0.6 1.2 -0.0 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 3.5 -0.3 1.9
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 0.1 0.2
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 2.1 1.4 -1.5
Medication: Aspirin 0.5 0.7 1.3 1.1 -0.4
Supplements: Vitamin C 0.6 0.7 1.1 -1.0 -0.5
Knee pain experienced in last month 0.1 0.2 0.4 -0.2 0.6
Hypertension (Self-reported) 1.0 2.7 3.0 -1.7 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.6 1.3 0.3
Illnesses of father: Heart disease 2.4 3.3 6.1 0.8 -2.5
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.5 -0.2
Smoking status: Previous 0.3 0.5 1.0 0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.2 -1.5 1.4
Whole body fat-free mass 0.3 1.8 2.4 -1.6 1.1
Leg fat-free mass (right) 0.3 1.7 2.8 -1.7 0.8
Arm fat percentage (left) 0.0 0.1 0.1 -0.1 -0.3
Average weekly red wine intake 0.8 1.1 1.9 1.4 -0.6
Handedness (chirality/laterality): Left-handed 1.3 1.5 2.6 0.7 -1.6
Mood swings 0.3 0.5 0.8 0.4 -0.9
Loneliness, isolation 0.0 0.0 0.0 -0.2 -0.1
Long-standing illness, disability or infirmity 1.2 1.9 2.3 -1.5 1.2
Ever had bowel cancer screening 1.6 1.8 2.3 1.5 -1.2
Diabetes diagnosed by doctor 1.6 2.6 2.7 -1.7 1.6
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.6 3.7 -1.9 1.2
Friendships satisfaction 4.8 5.9 6.2 -2.5 2.4
Qualifications: nursing, teaching 0.8 1.2 1.6 -0.9 1.3
Commuting to job workplace: Walk 1.8 2.0 3.7 -0.5 1.9
Eye problems/disorders: Cataract 2.8 3.2 3.4 -1.8 1.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.0 -0.4 1.0
Medication for cholesterol 0.1 0.2 0.3 0.6 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 1.7 -1.3 0.8
Back pain experienced in last month 1.3 1.9 3.6 1.9 0.5
Mineral and other dietary supplements 0.4 0.6 1.0 1.0 -0.5
Breast cancer (self-reported) 0.4 0.5 0.9 -1.0 0.1
Asthma (self-reported) 0.0 0.1 0.1 -0.3 -0.1
Osteoporosis (self-reported) 0.1 0.1 0.2 0.5 0.2
Osteoarthritis (self-reported) 0.2 0.3 0.5 -0.2 -0.7
Medication: Aspirin 0.6 0.8 1.5 1.2 -0.5
Medication: Gliclazide 0.1 0.1 0.2 0.0 0.5
Illnesses of father: None of the above (group 1) 1.7 2.1 3.6 -0.7 1.9
Smoking status: Current 0.0 0.1 0.1 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.2 8.4 2.9 0.2
Whole body water mass 0.4 2.1 2.7 -1.6 1.2
Leg predicted mass (right) 0.3 1.8 2.8 -1.7 0.9
Arm fat mass (left) 0.1 0.2 0.4 -0.7 0.2
Number of self-reported non-cancer illnesses 0.1 0.1 0.2 -0.1 0.4
Average weekly champagne plus white wine intake 0.9 1.2 1.8 1.3 0.7
Miserableness 0.3 0.5 1.0 -0.2 -1.0
Guilty feelings 0.2 0.3 0.4 -0.6 -0.5
Wears glasses or contact lenses 0.1 0.2 0.2 -0.5 -0.3
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.2 0.5
Hearing aid user 0.3 0.4 0.4 -0.6 -0.6
Mother’s age at death 0.8 1.1 1.9 -1.4 -0.5
Financial situation satisfaction 1.3 1.6 1.7 -1.3 1.3
Tinnitus: Yes, now most or all of the time 1.4 1.7 2.2 1.5 -1.1
Commuting to job workplace: Public transport 3.1 3.7 4.5 -2.1 1.7
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 0.6 -0.4
Medication: Blood pressure 0.4 0.8 1.5 -0.4 -1.2
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 -0.2 0.5
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.7 -0.9 1.6
High cholesterol (Self-reported) 0.8 1.5 1.6 -1.2 1.3
Medication: Bendroflumethiazide 0.5 0.8 1.0 -1.0 -0.7
Medication: Paracetamol 0.4 0.6 1.2 -0.2 -1.1
Medication: Lisinopril 0.0 0.0 0.0 -0.1 0.0
Medication: Atorvastatin 0.1 0.1 0.2 -0.0 -0.5
Illnesses of father: High blood pressure 0.4 0.5 0.6 0.8 0.6
Alcohol drinker status: Never 1.0 1.2 2.1 -1.4 0.5
Ever smoked 0.1 0.2 0.4 0.0 -0.6
Basal metabolic rate 0.3 1.6 2.3 -1.5 1.0
Leg fat percentage (left) 0.2 0.9 1.6 -1.3 0.4
Arm fat-free mass (left) 0.6 3.0 4.0 -2.0 1.4
Number of operations (self-reported) 0.2 0.3 0.5 0.1 -0.7
Average weekly beer plus cider intake 0.7 1.0 1.2 -0.9 1.1
Irritability 1.1 1.8 3.6 -1.9 -0.2
Risk taking 0.5 0.8 1.3 -0.5 1.2
Ever had prostate specific antigen (PSA) test 3.3 3.8 6.2 1.1 -2.5
Fractured/broken bones in last 5 years 3.0 3.9 6.4 -1.2 2.5
Age started oral contraceptive pill 0.5 0.6 0.9 0.6 -0.9
Diastolic blood pressure, automated reading 0.0 0.1 0.1 -0.2 -0.3
Ever depressed for a whole week 0.6 0.8 1.0 -0.8 1.0
Unable to work because of sickness or disability 0.4 0.5 1.0 -1.0 0.1
Commuting to job workplace: Cycle 0.5 0.6 1.3 1.1 -0.1
Myopia 0.4 0.5 0.8 0.9 -0.5
Vascular/heart problems diagnosed by doctor 0.6 1.7 2.0 1.4 -1.2
Cholesterol lowering medication 0.6 0.9 1.4 -1.2 0.7
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 5.7 2.4 -1.0
Pain experienced in last month 0.2 0.3 0.4 0.3 -0.7
Supplements: Calcium 0.3 0.3 0.3 0.5 -0.5
Basal cell carcinoma (self-reported) 0.4 0.5 0.8 -0.4 -0.9
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 0.1 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.0 -1.0 0.5
Heart disease (siblings) 1.2 1.4 1.6 1.3 -1.1
Alcohol drinker status: Previous 1.1 1.2 1.6 0.9 -1.3
Pack years of smoking 0.1 0.2 0.4 -0.6 0.2
Impedance of whole body 0.1 0.6 1.2 1.1 -0.3
Leg fat mass (left) 0.2 0.8 1.3 -1.1 0.5
Arm predicted mass (left) 0.7 3.6 4.6 -2.1 1.6