TWAS hub - IQUB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1290	0.0340	1.7e-11	0.063	0.113	0.110	0.105	0.096	3.7e-08	1.4e-13	2.5e-13	9.3e-13	9.4e-12
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0291	0.0158	7.3e-04	0.011	0.017	0.002	NA	0.008	1.9e-02	4.9e-03	1.5e-01	NA	3.4e-02
3	TCGA	Prostate Adenocarcinoma	0.1292	0.0458	4.1e-09	0.060	0.093	0.078	NA	0.074	6.5e-07	5.5e-10	1.6e-08	NA	3.6e-08
4	TCGA	Thyroid Carcinoma	0.0900	0.0360	7.1e-09	0.107	0.086	0.078	NA	0.095	1.6e-10	1.0e-08	4.5e-08	NA	1.6e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Blood Platelet Count	6.5	75.4	130.0	-11.4	-7.4	-1.7	-10.7
Loud music exposure frequency	6.2	6.8	9.7	-3.1	-2.7	-1.4	-2.9
Had other major operations	6.0	7.3	9.3	-2.5	-3.0	-2.2	-3.0
Medication: Omeprazole (e.g. Zanprol)	4.7	5.7	9.0	-1.2	-2.7	-3.0	-2.3
Falls in the last year	4.5	6.1	9.7	-1.8	-3.1	-2.2	-2.7
Handedness (chirality/laterality): Left-handed	4.3	5.1	8.4	-1.1	-2.9	-2.3	-2.4
Birth weight of first child	3.8	6.9	16.3	-4.0	-2.0	0.3	-2.7
Medication: Omeprazole	3.8	4.5	5.9	-1.5	-2.4	-2.3	-2.2
Chronic bronchitis/emphysema (father)	3.7	4.3	7.5	-2.7	-1.7	-0.5	-2.6
Age at last live birth	3.2	4.6	8.0	2.8	2.1	-0.3	2.4
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.6	6.0	-1.4	-2.4	-1.9	-1.7
Medication: Aspirin	3.0	3.9	5.7	-1.5	-2.2	-1.7	-2.4
Financial situation satisfaction	2.8	3.4	6.7	-2.6	-1.5	0.2	-2.2
Time employed in main current job	2.4	2.8	5.2	0.9	2.3	1.2	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	3.5	-1.8	-1.9	-1.1	-1.8
Illnesses of siblings: Diabetes	2.4	3.0	4.4	2.1	1.6	-0.6	2.1
Medication: Lansoprazole	2.2	2.5	3.4	-1.7	-1.9	-1.3	-1.4
Emphysema/chronic bronchitis	2.1	2.4	3.1	-1.0	-1.6	-1.8	-1.7
Smoking status: Previous	2.1	3.1	5.5	-2.2	-1.4	-0.0	-2.3
Breast cancer (self-reported)	2.1	2.5	3.8	-1.8	-1.6	-0.4	-2.0
Age started oral contraceptive pill	2.1	2.7	4.7	-2.2	-1.4	-0.6	-1.9
LDL Cholesterol	2.0	3.2	4.2	1.6	1.7	1.7	2.1
Mood swings	2.0	3.6	6.8	-0.2	-2.3	-2.6	-1.6
Medication: Aspirin	2.0	2.6	3.6	-1.0	-1.8	-1.6	-1.9
Ever unenthusiastic/disinterested for a whole week	1.9	2.4	3.6	-1.4	-1.6	-1.2	-1.9
Wheeze or whistling in the chest in last year	1.9	3.5	5.8	-0.9	-2.4	-1.2	-2.4
Medication: Lisinopril	1.9	2.5	5.3	2.3	1.1	1.1	1.5
Coronary Artery Disease (CAD)	1.8	2.1	3.8	-1.3	-2.0	-0.9	-1.5
Cholesterol lowering medication	1.8	2.6	4.2	-2.0	-1.8	-0.6	-1.6
Bipolar Disorder (2011)	1.7	1.7	3.2	0.2	-1.3	-1.8	-1.3
Vitamin and mineral supplements	1.7	2.3	4.4	0.7	1.6	2.1	1.4
Blood clot in the leg (DVT)	1.7	2.2	4.5	0.1	1.8	2.1	1.1
Number of full brothers	1.7	2.2	3.2	1.8	1.6	0.8	1.5
Heart attack	1.6	2.1	2.7	-1.7	-1.2	-1.4	-1.5
Type 2 Diabetes (T2D) (2018)	1.5	2.7	4.1	-0.8	-1.9	-1.5	-2.0
Taking other prescription medications	1.5	2.3	5.6	-0.4	-1.5	-2.4	-1.2
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.5	-0.8	-1.3	-1.9	-0.8
Past tobacco smoking	1.5	2.8	5.0	2.2	0.9	-1.2	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.3	-1.1	-2.1	-0.5	-1.8
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	2.9	-1.6	-1.5	-0.2	-1.7
Heart attack/myocardial infarction (self-reported)	1.5	2.0	2.5	-1.5	-1.2	-1.3	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.8	0.3	1.6	1.9	1.1
Cardiovascular Disease	1.4	4.5	10.8	1.9	-1.8	-3.3	-0.4
Ever had hysterectomy (womb removed)	1.4	1.6	2.4	1.4	1.2	0.6	1.6
Medication: Metformin	1.4	1.9	3.1	-0.6	-1.4	-1.5	-1.8
Hearing difficulty/problems with background noise	1.4	2.2	3.8	-0.6	-1.8	-1.9	-1.2
Depression (self-reported)	1.4	1.6	2.9	-0.9	-1.7	-1.1	-1.3
Migraine (self-reported)	1.4	1.7	3.6	0.0	-1.4	-1.9	-1.2
Illnesses of father: None of the above (group 1)	1.4	1.7	3.2	-0.6	1.8	1.1	1.4
Smoking Status	1.3	3.1	5.7	-2.2	-0.3	2.4	-1.3
Hearing difficulty/problems: Yes	1.3	2.0	7.7	0.3	-0.5	-2.8	-0.0
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.3	-1.8	-1.4	-0.4	-1.0
Diabetes (father)	1.3	1.7	3.2	-1.1	-1.4	-0.6	-1.8
Medication: Simvastatin	1.3	1.9	3.0	-1.0	-1.7	-1.3	-1.4
Illnesses of mother	1.3	1.6	5.1	-2.2	0.2	-0.9	-0.7
Pain all over the body in last month	1.2	1.3	2.1	-0.7	-0.9	-1.5	-1.3
Medication: Ramipril	1.2	1.5	2.7	-0.9	-1.2	-1.6	-1.0
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.5	-1.5	0.8	2.1	0.5
Diabetes diagnosed by doctor	1.2	2.0	3.0	-0.6	-1.5	-1.7	-1.5
Smoking status: Current	1.2	1.9	5.7	-0.0	1.2	2.4	0.8
Multivitamins +/- minerals	1.1	1.4	2.6	-0.2	-1.4	-1.6	-1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.0	0.0	1.4	1.4	1.1
Medication: Atenolol	1.1	1.4	3.2	1.8	0.7	-0.1	1.4
Illnesses of siblings	1.1	1.6	2.5	-0.7	-1.6	-1.1	-1.4
Arm fat percentage (right)	1.1	4.5	6.0	-2.4	-2.3	-1.1	-2.4
Prospective memory result	1.1	1.3	3.6	-0.1	1.2	1.9	0.5
Pulse rate, automated reading	1.1	3.4	12.6	-3.5	0.0	0.4	-1.0
Major Depression (MDD)	1.0	1.2	2.5	-1.6	-1.1	-0.2	-1.2
Fasting Glucose	1.0	1.2	2.8	0.2	-1.0	-1.7	-1.0
Chronotype (morning person)	1.0	2.2	3.3	1.8	1.1	-1.0	1.8
Number of treatments/medications taken	1.0	1.7	4.3	1.1	-1.0	-2.1	-0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.9	-0.0	-0.6	-2.0	-0.1
Age when periods started (menarche)	1.0	2.4	4.3	-1.7	-1.6	0.0	-2.1
Pulse rate	1.0	1.7	3.2	-1.8	-0.9	-1.0	-1.3
Shortness of breath walking on level ground	1.0	1.2	2.5	-0.7	-1.6	-0.9	-1.0
Chest pain or discomfort	1.0	1.4	3.7	-0.2	-1.2	-1.9	-0.7
Had major operations	1.0	1.2	1.8	1.3	0.8	1.3	0.7
Leg pain on walking	1.0	1.2	2.3	0.3	-1.5	-1.3	-0.9
Arm fat percentage (left)	1.0	3.8	5.6	-2.4	-2.0	-0.8	-2.2
Loneliness, isolation	1.0	1.4	2.7	-0.5	-1.7	-0.9	-1.3
Medication: Gliclazide	1.0	1.1	2.3	0.2	-1.1	-1.5	-1.0
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.5	-0.8	0.9	-1.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.2	-1.8	-0.9	-0.3	-1.0
Number of operations (self-reported)	1.0	1.4	2.4	-0.5	-1.6	-0.8	-1.5
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	-0.9	-1.4	-0.7	-1.0
Waist Hip Ratio (WHR)	0.9	3.9	6.2	-1.6	-2.5	-1.6	-2.2
Systolic Blood Pressure	0.9	4.4	10.8	1.8	-1.9	-3.3	0.0
Systolic blood pressure, automated reading	0.9	2.6	7.4	-0.5	-1.6	-2.7	-0.5
Maternal smoking around birth	0.9	1.3	2.3	1.5	-0.6	-1.5	0.5
High blood pressure	0.9	2.6	6.6	0.3	-1.7	-2.6	-0.9
Father’s age at death	0.9	1.2	2.0	0.3	1.4	0.8	1.4
Medication: Cholesterol lowering	0.9	1.4	3.3	0.5	-1.0	-1.8	-1.0
Medication: Amlodipine	0.9	1.2	2.2	-0.5	-1.5	-1.2	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.7	-1.6	-0.3	1.0	-0.8
Medication for pain relief, constipation, heartburn	0.9	1.6	4.7	0.3	1.0	2.2	0.8
Heart disease (mother)	0.9	1.1	4.2	2.0	-0.2	0.1	0.2
Overall health rating	0.9	1.9	2.5	-1.3	-1.4	-1.6	-1.1
Family relationship satisfaction	0.9	1.1	2.0	-0.7	-1.1	0.9	-1.4
Hypertension (Self-reported)	0.9	2.5	6.2	0.6	-1.7	-2.5	-0.9
Mother’s age at death	0.9	1.1	2.8	-1.2	0.2	1.7	-0.3
Medication: Bendroflumethiazide	0.9	1.3	3.0	0.4	-1.3	-1.7	-0.6
Vascular/heart problems diagnosed by doctor	0.9	2.4	6.2	-0.5	1.6	2.5	0.8
Alcohol drinker status: Previous	0.9	1.0	2.4	1.5	0.8	0.3	0.9
Severe depression (siblings)	0.8	0.9	1.3	-0.6	-1.1	-1.0	-0.9
Trunk fat percentage	0.8	3.0	5.6	-2.4	-1.5	-0.2	-2.0
Waist circumference	0.8	2.9	3.9	-1.5	-1.9	-1.3	-2.0
Number of children fathered	0.8	0.9	2.3	-1.5	-0.3	0.5	-1.1
Age at first live birth	0.8	1.5	2.8	1.7	0.9	-0.7	1.4
Health satisfaction	0.8	1.0	1.5	-1.0	-1.2	-0.2	-1.2
Eye problems/disorders: None of the above	0.8	0.9	3.0	-0.4	0.7	1.7	0.2
Medication: Blood pressure	0.8	1.5	2.9	1.0	-1.2	-1.7	-0.7
Intelligence (Savage-Jansen 2018)	0.7	2.1	6.9	0.9	-0.7	-2.6	-0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	0.9	0.7	-0.7	1.3
Current tobacco smoking	0.7	1.1	3.2	-0.2	0.8	1.8	0.6
Neuroticism score	0.7	1.4	2.4	0.2	-1.3	-1.6	-1.1
Arm fat mass (right)	0.7	2.9	4.0	-1.6	-2.0	-1.1	-1.9
Length of working week for main job	0.7	0.8	2.3	1.5	0.5	0.5	0.6
Tense / ‘highly strung’	0.7	1.1	1.5	-0.2	-1.2	-1.2	-1.2
Pulse wave reflection index	0.7	0.8	1.7	0.7	0.9	1.3	0.6
Headache pain in last month	0.7	1.2	3.8	0.1	-0.9	-1.9	-0.1
Glaucoma (self-reported)	0.7	0.9	2.0	-1.4	-0.9	0.1	-0.8
Body fat percentage	0.7	2.6	4.5	-2.1	-1.5	-0.4	-1.9
Medication: Seretide 50 evohaler	0.7	0.8	2.6	1.6	0.4	0.5	0.2
Suffer from ‘nerves’	0.7	1.1	2.2	-0.4	-1.5	-1.1	-0.9
Illnesses of father: Heart disease	0.7	1.0	1.6	0.7	-1.3	-0.8	-1.1
Eye problems/disorders: Cataract	0.7	0.8	1.3	1.0	1.0	-0.2	1.1
Osteoarthritis (self-reported)	0.7	0.9	1.9	-1.4	-0.8	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.9	-0.4	1.1	1.7	1.2
Ever smoked	0.7	1.2	1.6	-1.2	-0.7	1.3	-1.2
Ever depressed for a whole week	0.7	0.9	1.4	-0.8	-0.9	0.8	-1.2
Heart disease (siblings)	0.7	0.8	1.5	0.2	1.2	1.2	0.6
Worry (Nagel 2018)	0.6	1.3	2.4	1.6	-0.3	-1.6	0.5
Sensitivity / hurt feelings	0.6	1.1	3.1	1.8	0.1	-0.8	0.7
Relative age of first facial hair	0.6	1.2	2.2	1.5	0.6	-0.9	1.2
Supplements: Zinc	0.6	0.6	1.7	1.3	0.6	-0.3	0.6
Pack years adult smoking proportion	0.6	1.0	3.1	0.4	-0.6	-1.8	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.4	-0.9	-1.2	-0.3	-1.0
Trunk fat mass	0.6	2.6	4.2	-2.0	-1.6	-0.2	-2.0
Alcohol intake versus 10 years previously	0.6	0.9	1.6	1.3	0.4	-0.8	1.1
Happiness	0.6	0.7	1.4	-0.1	-1.0	0.6	-1.2
Mouth/teeth dental problems: Dentures	0.6	1.1	1.7	-0.7	1.3	1.3	0.7
Lung cancer (father)	0.6	0.7	1.9	-1.4	-0.6	-0.0	-0.8
Pulse wave Arterial Stiffness index	0.6	0.6	1.4	0.2	0.8	1.2	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	0.1	1.0	1.3	0.3
Medication: Paracetamol	0.6	1.0	2.1	0.5	1.5	0.2	1.3
Leg fat percentage (right)	0.6	2.2	3.3	-1.8	-1.6	-0.7	-1.6
Medication: Allopurinol	0.6	0.8	1.9	-0.8	-0.9	0.2	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	0.7	0.3	-1.3	0.9
Supplements: Vitamin C	0.6	0.7	2.9	0.2	-0.2	-1.7	-0.1
Friendships satisfaction	0.6	0.7	1.1	-0.8	-0.5	1.0	-0.9
Number of self-reported non-cancer illnesses	0.6	1.0	3.0	0.1	-0.9	-1.7	-0.5
Illnesses of father: High blood pressure	0.6	0.8	1.5	1.2	-0.5	-1.1	0.4
Leg fat percentage (left)	0.6	2.3	4.3	-2.1	-1.4	-0.5	-1.6
Irritability	0.6	1.0	1.5	0.3	-1.2	-0.9	-1.2
Pack years of smoking	0.6	0.8	2.6	-0.1	-0.6	-1.6	-0.6
Neuroticism (Nagel 2018)	0.5	1.1	2.1	1.1	-0.9	-1.4	-0.2
Allergy or Eczema	0.5	1.3	1.9	-1.4	-1.0	0.9	-1.1
Lung FVC	0.5	2.7	5.1	-0.4	1.7	2.3	1.7
Neuroticism	0.5	1.1	3.3	1.8	0.1	-0.7	0.7
Average weekly fortified wine intake	0.5	0.6	1.5	0.2	-0.6	-1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.8	0.0	-0.8	-1.7	-1.0
High blood pressure (mother)	0.5	0.8	2.1	1.4	-0.5	0.9	0.0
Body mass index (BMI)	0.5	1.9	2.9	-1.1	-1.7	-1.3	-1.4
Alcohol usually taken with meals	0.5	0.7	1.3	-1.1	-0.7	-0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	4.1	0.4	-0.6	-2.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	-0.0	-1.4	-0.4	-1.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.4	-0.6	-1.2	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.5	0.1	1.2	1.9	1.3
Gout (self-reported)	0.5	0.7	1.3	-1.0	-0.4	0.6	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.5	1.0	-0.3	-1.2	-0.1
Pulse wave peak to peak time	0.5	0.6	1.1	-0.2	-0.8	-1.0	-0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.5	0.7	-0.6	-0.8	-0.8	-0.7
Neck or shoulder pain in last month	0.5	0.6	1.2	-1.1	-0.4	0.2	-1.1
Mean time to correctly identify matches	0.5	0.9	3.2	-1.8	0.4	0.6	-0.1
Number of full sisters	0.5	0.6	1.5	-1.2	-0.5	0.2	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.1	-0.8	-0.9	-1.1	-0.9
Arm fat mass (left)	0.5	2.2	3.0	-1.5	-1.7	-0.9	-1.7
Medication: Paracetamol	0.5	0.7	1.4	0.4	1.2	-0.2	1.1
Primary Biliary Cirrhosis	0.4	0.6	1.2	1.1	0.3	0.9	0.4
Blood Red Count	0.4	3.9	7.3	-0.7	-2.6	-1.0	-2.7
Hypothyroidism (self reported)	0.4	1.0	1.3	-1.1	-1.0	-0.6	-1.1
Average weekly spirits intake	0.4	0.4	0.7	0.2	-0.9	-0.7	-0.7
Medication: Co-codamol	0.4	0.5	1.2	-0.6	-0.6	-0.2	-1.1
Relative age voice broke	0.4	0.6	1.2	1.0	0.2	-1.1	0.4
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.4	-0.4	-1.2	0.1
Financial difficulties in last 2 years	0.4	0.6	1.4	-0.1	-0.8	-1.2	-0.6
Mouth/teeth dental problems	0.4	0.6	2.1	1.5	0.2	0.0	0.5
Diabetes (self-reported)	0.4	0.6	1.6	-0.1	-0.7	-1.2	-0.7
Fluid intelligence score	0.4	0.9	2.5	1.0	-0.1	-1.6	-0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	0.3	1.2	1.6	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	1.0	1.0	0.2	-0.7	0.5
Impedance of arm (left)	0.4	1.8	3.8	-1.6	0.4	1.9	-0.7
Peak expiratory flow (PEF)	0.4	0.9	2.0	-0.1	1.0	1.4	0.8
High blood pressure (siblings)	0.4	0.6	1.7	-0.2	0.8	1.3	0.3
Exposure to tobacco smoke outside home	0.4	0.5	1.8	1.3	0.3	-0.2	0.4
Whole body fat mass	0.4	1.8	2.6	-1.5	-1.5	-0.5	-1.6
Leg fat mass (right)	0.4	1.4	2.1	-1.1	-1.5	-0.7	-1.3
Long-standing illness, disability or infirmity	0.4	0.6	0.8	-0.5	-0.9	-0.9	-0.7
Back pain experienced in last month	0.4	0.6	1.8	0.4	-0.1	-1.3	0.5
Miserableness	0.4	0.6	1.0	-0.5	-0.9	-1.0	-0.6
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.9	-0.6	0.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	-1.0	0.5	-0.7	-0.2
Supplements: Calcium	0.4	0.4	0.7	-0.2	0.8	0.6	0.8
Leg fat mass (left)	0.4	1.4	1.9	-1.3	-1.4	-0.5	-1.3
Bipolar Disorder (2018)	0.3	0.4	0.6	0.3	-0.8	-0.7	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	1.1	-0.5	-1.1	-0.0
Schizophrenia (2018)	0.3	0.6	1.4	1.2	-0.1	-0.9	0.5
Reaction Time	0.3	0.5	1.8	-1.3	-0.1	0.5	-0.2
Age at First Birth	0.3	0.5	1.0	-1.0	-0.4	-0.6	-0.5
HbA1C	0.3	0.4	0.5	0.5	0.7	-0.7	0.6
Schizophrenia (2014)	0.3	0.7	1.3	1.1	-0.1	-1.1	0.6
Blood Eosinophil Count	0.3	2.3	7.1	-0.6	1.3	2.7	0.4
Blood White Count	0.3	2.1	3.8	0.2	1.9	1.4	1.7
BMI	0.3	1.6	2.9	-1.0	-1.5	-0.5	-1.7
Lung FEV1/FVC ratio	0.3	1.6	4.4	2.1	0.5	0.3	1.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.3	-0.8	0.1	-0.8
Serious illness, injury or assault to yourself	0.3	0.3	0.7	0.2	-0.7	-0.8	-0.2
Number of incorrect matches in round	0.3	0.5	0.8	0.7	0.9	0.3	0.9
Weight	0.3	1.3	2.0	-1.0	-1.4	-0.8	-1.4
Impedance of arm (right)	0.3	1.4	2.8	-1.7	-0.2	1.2	-1.2
Hip circumference	0.3	1.4	1.8	-1.1	-1.3	-0.9	-1.4
Hair/balding pattern: Pattern 4	0.3	0.7	0.9	0.9	0.9	0.4	1.0
Forced vital capacity (FVC), Best measure	0.3	0.9	1.5	0.2	0.9	1.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.4	0.4	-0.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.6	0.4	-0.8	0.7
Alcohol intake frequency.	0.3	0.7	1.6	-0.4	-1.0	-1.3	-0.4
Knee pain experienced in last month	0.3	0.4	1.2	0.6	-0.0	-1.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	1.0	-0.1	-0.3	-0.2
Commuting to job workplace: Walk	0.3	0.3	1.0	-1.0	-0.5	-0.0	-0.4
Mineral and other dietary supplements	0.3	0.4	1.0	1.0	0.3	0.6	0.2
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.2	-0.9	-0.0	-0.8
Medication: Atorvastatin	0.3	0.4	0.9	0.3	-0.5	-0.9	-0.5
Risk taking	0.3	0.4	1.3	0.1	-0.3	1.1	-0.6
Impedance of whole body	0.3	1.5	4.2	-1.0	0.8	2.1	-0.1
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.7	-0.8	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.2	0.8	0.3	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.3	-0.7	0.3	-0.2
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.7	-0.9	-0.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.8	-0.1	-0.4	-1.3	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.6	0.5	-0.0	0.5
Medication for hormone replacement therapy	0.2	0.2	0.4	0.2	-0.6	0.5	-0.6
Diabetes (mother)	0.2	0.2	0.8	0.9	0.1	0.3	0.2
Townsend deprivation index at recruitment	0.2	0.2	0.3	-0.5	0.4	-0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.5	0.3	0.6	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.4	-0.8	-0.1	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.6	-0.6	0.7	-0.7
Supplements: Glucosamine	0.2	0.3	0.5	-0.7	0.4	-0.7	0.3
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.4	0.8	0.8	0.6
Sitting height	0.2	1.2	2.0	-0.9	-1.2	-0.7	-1.4
Impedance of leg (left)	0.2	0.8	2.2	-0.4	0.9	1.5	0.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.4	-0.7	-0.3	-0.5
Had menopause	0.2	0.2	0.8	-0.9	-0.1	-0.1	0.0
Forced vital capacity (FVC)	0.2	0.8	1.2	0.1	1.0	0.9	1.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.4	-0.3	0.5	-0.6
Worrier / anxious feelings	0.2	0.3	0.8	-0.5	-0.3	-0.9	-0.2
Number of live births	0.2	0.3	1.2	-0.1	-0.3	-1.1	-0.1
Noisy workplace	0.2	0.3	0.4	-0.6	-0.3	0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	-1.1	0.1	0.1	-0.3
Comparative body size at age 10	0.2	0.4	1.1	0.0	0.7	0.3	1.1
Medication: Ibuprofen	0.2	0.2	0.6	0.6	-0.1	-0.8	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	0.3	0.6	0.2	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.5	0.7	0.3	0.2
Asthma (self-reported)	0.2	0.4	1.1	0.5	-0.3	-1.1	-0.2
Hearing aid user	0.2	0.2	0.6	0.8	0.3	-0.2	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.0	-0.6	-0.7	-0.4
High cholesterol (Self-reported)	0.2	0.3	0.4	-0.3	-0.6	-0.6	-0.5
Alcohol drinker status: Never	0.2	0.2	0.8	-0.9	-0.0	0.2	0.2
Diastolic blood pressure, automated reading	0.2	0.6	2.0	0.2	-0.5	-1.4	0.3
Unable to work because of sickness or disability	0.2	0.3	0.7	0.2	0.3	0.9	0.4
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.4	0.1	-0.6	0.6
Pain experienced in last month	0.2	0.3	0.7	-0.1	-0.4	0.8	-0.6
Depression (Nagel 2018)	0.1	0.1	0.2	0.2	-0.5	0.2	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.2	-0.6	0.3	-0.1
Crohns Disease (2017)	0.1	0.3	0.9	-0.4	0.1	-0.9	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.5	-0.4	-0.6	0.1
Breast Cancer	0.1	0.2	0.5	-0.0	-0.7	0.3	-0.5
Ovarian Cancer	0.1	0.1	0.2	0.5	0.4	-0.1	0.0
Prostate Cancer	0.1	0.2	0.7	0.8	0.2	-0.3	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.0
Crohns Disease (2012)	0.1	0.2	0.3	-0.1	0.6	-0.4	0.6
Mean Putamen Volume	0.1	0.1	0.4	0.1	-0.3	-0.2	-0.6
HDL Cholesterol	0.1	0.1	0.3	0.0	-0.4	-0.1	-0.5
Lupus	0.1	0.2	0.3	-0.2	0.5	0.4	0.3
Neuroticism (2016)	0.1	0.1	0.3	-0.1	-0.5	-0.2	-0.2
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	0.5	0.5	0.1
Triglycerides	0.1	0.1	0.2	0.5	0.3	0.3	0.3
Heel T-Score	0.1	0.6	1.8	0.7	-0.1	-1.3	-0.2
Height	0.1	1.1	2.0	0.6	1.4	1.1	0.9
Angina	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3
Impedance of leg (right)	0.1	0.6	2.1	-0.2	0.6	1.4	0.2
Leg fat-free mass (left)	0.1	0.7	1.5	0.0	-1.2	-0.9	-0.8
Leg predicted mass (left)	0.1	0.7	1.3	0.1	-1.1	-1.0	-0.7
Qualifications: None of the above	0.1	0.1	0.4	-0.6	0.3	-0.2	0.1
Allergy	0.1	0.2	0.5	0.1	0.2	-0.7	0.3
Trunk fat-free mass	0.1	0.6	1.1	0.4	-0.9	-1.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.1	-0.7	-0.7	-0.6
Asthma	0.1	0.2	0.5	0.3	-0.3	-0.7	-0.3
Trunk predicted mass	0.1	0.6	1.1	0.3	-1.0	-1.1	-0.6
Standing height	0.1	0.5	1.7	0.3	0.6	1.3	-0.0
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.4	0.0	-0.3	0.3
Breastfed as a baby	0.1	0.1	0.2	-0.1	0.4	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	0.3	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.2	-0.4	-0.5	-0.2
Birth weight	0.1	0.3	1.1	-1.1	-0.3	0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.5	-0.3	-0.5	0.3
Angina (self-reported)	0.1	0.1	0.3	-0.2	-0.3	-0.5	-0.3
Arm predicted mass (right)	0.1	0.3	0.8	0.5	-0.6	-0.9	-0.2
Comparative height size at age 10	0.1	0.7	2.8	-0.4	0.3	1.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.0	1.0	0.3	0.1	0.1
Whole body fat-free mass	0.1	0.7	1.2	0.3	-1.1	-1.1	-0.6
Leg fat-free mass (right)	0.1	0.5	1.0	0.1	-1.0	-0.9	-0.6
Average weekly red wine intake	0.1	0.2	0.5	-0.7	0.3	-0.2	-0.1
Qualifications: nursing, teaching	0.1	0.1	0.3	0.2	-0.3	0.4	-0.5
Medication for cholesterol	0.1	0.2	0.7	-0.0	0.8	0.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.6	0.0	-0.3	-0.3
Whole body water mass	0.1	0.7	1.2	0.3	-1.0	-1.1	-0.6
Leg predicted mass (right)	0.1	0.6	1.0	0.1	-1.0	-0.9	-0.6
Wears glasses or contact lenses	0.1	0.2	0.5	0.7	-0.0	-0.3	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.5	0.3	0.2	-0.1
Basal metabolic rate	0.1	0.8	1.4	0.1	-1.2	-1.1	-0.8
Arm fat-free mass (left)	0.1	0.7	1.5	0.4	-0.9	-1.2	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.5	-0.3	0.0	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.4	0.5	-0.1	-0.7	0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.1	-0.3	0.4	-0.0
Myopia	0.1	0.2	0.3	-0.1	-0.5	0.3	-0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.5	0.2	0.2	-0.1
Arm predicted mass (left)	0.1	0.6	1.4	0.6	-0.7	-1.2	-0.3
Ulcerative Colitis	0.0	0.1	0.2	-0.2	-0.4	0.2	-0.1
Respiratory disease	0.0	0.1	0.2	0.4	0.1	-0.2	0.1
Hair Pigment	0.0	0.6	1.1	0.3	0.9	0.7	1.0
Tanning	0.0	0.2	0.3	-0.1	0.5	0.4	0.5
Hand grip strength (left)	0.0	0.1	0.2	0.4	0.3	-0.1	0.5
Hand grip strength (right)	0.0	0.0	0.1	0.1	0.1	0.4	-0.0
Fed-up feelings	0.0	0.1	0.2	0.5	0.2	-0.0	0.2
Nervous feelings	0.0	0.0	0.1	0.1	-0.3	0.1	0.1
Arm fat-free mass (right)	0.0	0.2	0.4	0.4	-0.6	-0.6	-0.2
Worry too long after embarrassment	0.0	0.1	0.1	-0.1	-0.3	-0.2	-0.3
Qualifications: College or University degree	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.4
Ever had bowel cancer screening	0.0	0.0	0.0	0.2	-0.0	0.0	0.1
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.4	-0.2	-0.2	-0.1
Guilty feelings	0.0	0.1	0.1	0.2	0.0	-0.3	0.3
Medication: Blood pressure	0.0	0.1	0.1	0.2	-0.4	0.1	-0.2

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