Hub : Genes

JMY

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0520	0.0200	6.6e-04	0.057	0.017	0.046	0.029	0.048	1.9e-07	2.9e-03	2.4e-06	1.7e-04	1.6e-06
2	GTEx	Testis	0.1060	0.0470	6.1e-03	0.118	NA	0.063	NA	0.096	6.9e-06	NA	9.4e-04	NA	4.9e-05
3	NTR	Blood	0.0166	0.0072	3.3e-03	0.012	0.004	0.002	0.004	0.007	6.6e-05	1.6e-02	6.6e-02	1.8e-02	2.5e-03
4	YFS	Blood	0.0453	0.0108	1.2e-14	0.069	0.044	0.062	0.060	0.066	1.5e-21	3.4e-14	2.1e-19	5.8e-19	1.3e-20
5	TCGA	Colon Adenocarcinoma	0.0640	0.0320	7.7e-05	0.091	0.095	0.083	NA	0.087	5.9e-06	4.0e-06	1.6e-05	NA	9.7e-06
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0529	0.0361	7.8e-04	0.026	0.023	0.021	NA	0.023	5.6e-04	1.0e-03	1.9e-03	NA	1.2e-03
7	TCGA	Thyroid Carcinoma	0.0510	0.0300	2.9e-04	0.044	0.033	0.035	NA	0.032	3.8e-05	3.5e-04	2.1e-04	NA	3.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	0.7	0.0	-0.5	0.0	-0.0	0.4	-0.2	-0.8
Bipolar Disorder or Schizophrenia	0.8	1.9	3.6	-1.9	1.3	1.2	1.3	1.3	1.1	1.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.4	0.4	-0.3	-0.7	-0.6	-0.8	-1.2	-0.6
Depression (Nagel 2018)	4.9	7.4	10.2	2.4	-2.6	-2.8	-2.5	-2.7	-3.2	-2.9
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.2	-0.7	1.1	1.4	1.5	0.7	1.4	0.9
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.0	0.4	-0.1	-0.1	-0.3	-0.4	-0.1
Schizophrenia (2018)	1.7	3.6	6.1	-2.5	2.1	1.6	1.8	1.4	1.6	2.2
Schizophrenia vs Biploar Disorder	3.5	4.6	5.4	-2.2	2.3	2.0	2.2	2.0	1.9	2.3
Worry (Nagel 2018)	1.0	2.0	3.4	-0.9	1.8	1.6	1.5	1.0	1.5	1.3
Alzheimer’s Disease (in mother)	1.2	1.4	2.0	0.7	-1.4	-1.3	-1.2	-0.9	-1.2	-1.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.3	-0.2	-0.1	-0.2	-0.4	-0.3	-0.3
Alzheimer’s Disease (including proxy)	2.1	3.0	4.0	1.5	-1.8	-1.7	-1.8	-2.0	-1.4	-1.9
Crohns Disease (2017)	0.3	0.6	1.3	0.6	-0.8	-1.1	-0.8	-0.8	-0.7	-0.6
Irritable Bowel Disease (IBD)	0.7	1.8	2.3	0.9	-1.5	-1.5	-1.5	-1.4	-1.1	-1.2
Ulcerative Colitis (UC)	0.9	1.7	2.3	0.9	-1.5	-1.3	-1.5	-1.4	-1.0	-1.3
Major Depression (MDD)	3.9	4.7	6.1	1.5	-2.4	-2.5	-1.9	-2.2	-2.1	-2.5
Reaction Time	1.1	2.1	3.0	-1.0	1.7	1.6	1.4	1.2	1.7	1.3
Verbal and Numeric Reasoning (VNR)	1.4	3.4	4.3	-1.9	1.7	2.1	2.0	1.8	1.9	1.3
Breast Cancer	0.8	1.9	2.8	1.7	-1.1	-1.4	-1.5	-1.6	-0.7	-1.4
Ovarian Cancer	0.6	0.8	1.8	1.4	-0.4	-0.6	-1.0	-1.3	0.6	-0.3
Prostate Cancer	0.2	0.2	0.9	-0.6	-0.5	-0.4	-0.2	0.3	-0.9	0.1
Age at First Birth	2.1	3.0	3.5	-1.9	1.9	1.7	1.9	1.6	1.6	1.7
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.4	0.2	0.5	0.4	0.6	0.3	-0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.1	-0.1	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.3	-0.0	0.3	0.6	0.0	-0.1	0.3
Crohns Disease (2012)	0.0	0.0	0.2	0.1	-0.2	-0.1	-0.1	-0.3	0.4	-0.1
Mean Putamen Volume	2.1	2.4	3.6	1.2	-1.9	-1.8	-1.5	-1.3	-1.1	-1.8
Fasting Glucose	0.2	0.2	0.7	-0.1	-0.5	-0.3	-0.2	0.1	-0.8	-0.5
HbA1C	0.6	0.6	1.2	-1.1	0.9	0.5	0.6	0.7	0.9	0.8
HDL Cholesterol	3.6	6.0	9.4	-1.8	2.6	2.3	2.5	2.0	3.1	2.5
LDL Cholesterol	2.1	3.4	4.4	-1.6	1.8	2.1	2.0	1.8	1.8	1.6
Lupus	0.0	0.1	0.2	-0.5	0.0	-0.2	0.1	0.1	-0.4	0.1
Neuroticism (2016)	1.6	2.3	3.5	1.2	-1.5	-1.6	-1.7	-1.0	-1.9	-1.6
Primary Biliary Cirrhosis	2.2	3.2	6.2	1.1	-2.1	-1.5	-1.1	-2.1	-1.7	-2.5
Rheumatoid Arthritis	1.8	2.4	4.5	-2.1	1.3	1.5	1.6	1.4	1.3	1.4
Schizophrenia (2014)	1.3	2.9	5.3	-2.3	1.8	1.4	1.5	1.5	1.6	1.7
Triglycerides	1.3	2.1	2.8	1.0	-1.7	-1.4	-1.5	-1.5	-1.3	-1.6
Type 2 Diabetes (T2D) (2012)	4.9	5.7	8.6	1.9	-2.9	-2.8	-1.9	-1.8	-2.5	-2.6
Ulcerative Colitis	2.5	3.6	5.0	1.3	-2.2	-1.8	-2.2	-2.1	-1.4	-2.0
Blood Eosinophil Count	0.0	0.2	0.4	-0.1	-0.2	0.5	0.7	0.3	-0.3	-0.5
Blood Platelet Count	1.2	13.3	16.0	-3.0	3.9	3.8	4.0	3.5	3.6	3.8
Blood Red Count	0.1	0.6	2.2	-0.1	-0.8	0.3	0.1	0.2	-1.5	-1.1
Blood White Count	2.5	18.7	23.5	4.2	-4.5	-4.3	-4.0	-3.6	-4.7	-4.8
Heel T-Score	1.7	13.3	20.0	3.7	-3.7	-3.5	-3.4	-3.7	-2.8	-4.5
BMI	1.4	8.0	10.8	2.5	-3.2	-2.6	-2.5	-2.2	-3.3	-3.2
Height	0.7	12.9	17.3	3.1	-3.6	-3.9	-4.2	-3.9	-2.9	-3.3
Waist Hip Ratio (WHR)	0.2	0.8	1.6	0.8	-1.3	-0.8	-0.6	-0.2	-1.0	-1.2
Systolic Blood Pressure	0.1	0.7	1.0	0.8	-0.8	-0.9	-0.9	-0.7	-1.0	-0.8
Smoking Status	2.2	5.3	7.4	2.4	-2.3	-2.2	-1.8	-2.2	-2.5	-2.7
Allergy or Eczema	0.9	2.3	5.1	2.2	-0.7	-1.3	-1.7	-2.2	0.3	-1.0
Cardiovascular Disease	0.6	2.1	4.4	0.9	-1.6	-1.3	-0.9	-1.2	-2.1	-1.7
Hypothyroidism (self reported)	0.2	0.5	1.5	1.2	-0.4	-0.7	-0.4	-1.0	-0.3	-0.6
Respiratory disease	4.8	10.8	14.2	2.7	-3.6	-3.3	-3.2	-3.2	-3.1	-3.8
Type 2 Diabetes (T2D) (2018)	5.1	9.5	13.0	2.2	-3.4	-3.1	-2.9	-2.7	-3.6	-3.6
Lung FEV1/FVC ratio	0.2	0.9	1.8	-1.3	-0.4	0.9	1.3	1.4	-0.5	0.3
Lung FVC	6.3	31.8	39.0	-4.5	6.1	6.2	6.0	5.2	5.9	5.4
Neuroticism	0.0	0.1	0.5	-0.4	0.2	0.0	0.3	0.1	-0.7	-0.1
Chronotype (morning person)	0.1	0.2	0.5	-0.6	-0.2	-0.1	0.2	0.7	-0.3	-0.1
Hair Pigment	0.0	0.1	0.3	0.1	-0.2	-0.1	-0.2	-0.5	-0.4	-0.4
Tanning	0.3	3.1	4.1	2.0	-1.8	-1.6	-1.6	-1.9	-1.4	-1.9
Hand grip strength (left)	0.2	0.4	0.7	-0.6	0.8	0.6	0.6	0.3	0.8	0.8
Number of treatments/medications taken	1.4	2.5	3.7	1.4	-1.3	-1.7	-1.6	-1.6	-1.4	-1.9
Average weekly spirits intake	2.6	3.3	5.2	2.3	-1.7	-1.5	-2.0	-1.8	-1.2	-2.0
Sensitivity / hurt feelings	0.0	0.1	0.2	0.1	0.5	0.1	0.1	0.4	-0.1	-0.1
Frequency of depressed mood in last 2 weeks	2.9	4.0	6.1	1.9	-1.9	-2.1	-1.6	-1.7	-2.5	-2.2
Hearing difficulty/problems: Yes	0.2	0.3	1.5	-0.4	-0.5	-0.1	-0.2	0.2	-1.2	-0.5
Relative age of first facial hair	0.4	0.8	2.1	1.2	-0.6	-0.1	-0.6	-1.5	1.0	-0.7
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	5.2	2.2	-1.6	-2.1	-2.3	-2.3	-1.0	-1.3
Ever used hormone-replacement therapy (HRT)	2.1	2.7	3.4	1.6	-1.8	-1.7	-1.6	-1.3	-1.5	-1.8
Ever had hysterectomy (womb removed)	1.4	1.5	3.1	1.1	-1.3	-1.0	-1.1	-1.3	-0.9	-1.8
Systolic blood pressure, automated reading	0.3	1.0	1.8	0.9	-1.0	-1.0	-1.0	-0.5	-1.3	-0.9
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.4	1.0	-0.9	-1.1	-1.0	-0.3	-1.2	-1.0
Angina	0.3	0.3	0.9	-0.5	0.6	0.5	0.7	1.0	0.0	0.3
Medication for hormone replacement therapy	1.0	1.1	2.6	-0.2	-1.2	-1.2	-1.1	-0.1	-1.6	-1.0
Vitamin and mineral supplements	2.2	3.0	4.3	-1.5	1.8	1.9	1.4	1.8	1.7	2.1
Supplements: Zinc	1.3	1.4	2.1	1.5	-1.2	-1.3	-1.1	-1.3	-0.8	-1.0
Medication: Co-codamol	1.0	1.2	1.6	0.7	-1.0	-1.3	-1.2	-1.1	-1.2	-0.8
Medication: Metformin	5.1	7.2	8.8	2.7	-2.7	-2.7	-2.5	-2.8	-2.5	-3.0
Diabetes (father)	0.6	0.8	2.1	0.8	-0.6	-1.0	-1.5	-1.1	-0.1	-0.3
Diabetes (mother)	9.0	11.4	13.4	3.5	-3.2	-3.7	-3.3	-3.5	-3.0	-3.5
Severe depression (siblings)	2.8	3.2	5.9	2.4	-1.6	-1.7	-1.4	-1.6	-1.6	-1.9
Pack years adult smoking proportion	2.5	3.8	5.2	1.7	-2.3	-1.8	-1.8	-2.2	-1.7	-2.1
Impedance of leg (right)	0.0	0.2	0.5	-0.5	0.6	0.3	0.3	0.3	0.4	0.7
Leg fat-free mass (left)	1.6	8.7	9.6	3.0	-3.0	-3.1	-3.1	-2.9	-2.6	-3.0
Trunk fat percentage	2.9	11.8	15.4	3.1	-3.6	-3.5	-3.3	-2.8	-3.9	-3.7
Hand grip strength (right)	0.5	1.3	2.0	-1.4	1.3	1.0	1.0	0.9	1.2	1.2
Townsend deprivation index at recruitment	5.5	7.7	8.7	2.7	-2.8	-2.8	-2.5	-2.7	-3.0	-2.9
Current tobacco smoking	5.4	8.9	12.9	3.6	-2.8	-2.7	-2.7	-3.6	-2.0	-3.2
Average weekly fortified wine intake	0.1	0.1	0.7	-0.2	-0.2	-0.3	-0.1	0.4	-0.8	-0.2
Maternal smoking around birth	0.4	0.6	1.4	0.9	-0.4	-1.0	-0.8	-1.2	-0.1	-0.5
Fed-up feelings	0.4	0.8	2.1	0.6	-0.4	-1.0	-0.9	-1.0	-1.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	8.5	11.3	15.3	3.3	-3.1	-3.5	-3.0	-3.1	-3.9	-3.4
Relative age voice broke	2.5	3.7	5.2	2.0	-2.1	-1.6	-2.0	-2.1	-1.2	-2.3
Taking other prescription medications	1.5	2.3	3.8	1.5	-1.0	-1.6	-1.6	-2.0	-1.0	-1.7
Age when periods started (menarche)	0.6	1.5	2.2	-1.0	1.3	1.5	1.5	1.3	1.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	-0.7	-0.3	-0.4	0.2	-0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	4.9	0.9	-2.1	-2.0	-1.9	-1.3	-2.2	-2.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.5	0.1	0.4	0.5	0.7	-0.2	0.2
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.2	0.3	1.0	1.0	1.1	-0.6	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.6	-0.2	-0.8	-0.5	-0.5	-0.2	-0.2
High blood pressure	0.0	0.1	0.3	0.2	-0.2	0.1	0.1	-0.3	-0.6	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.0	1.4	-0.4	-0.7	-1.0	-1.4	0.2	-0.6
Multivitamins +/- minerals	1.6	2.0	2.9	1.6	-1.4	-1.4	-1.2	-1.6	-0.8	-1.7
Stomach or abdominal pain in last month	0.1	0.2	0.7	-0.6	-0.0	-0.1	-0.2	0.4	-0.8	0.2
Supplements: Glucosamine	1.0	1.3	2.2	0.9	-1.5	-1.2	-0.7	-0.5	-1.4	-1.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.4	0.8	-0.7	-1.1	-1.1	-1.2	-0.5	-0.7
Medication: Atenolol	1.4	1.7	2.9	-1.6	1.1	1.3	1.6	1.7	0.1	1.0
Medication: Levothyroxine sodium	0.0	0.1	0.3	0.0	0.0	-0.1	-0.2	-0.6	0.3	-0.3
Sitting height	1.1	7.5	8.5	2.6	-2.6	-2.8	-2.9	-2.9	-2.4	-2.9
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	0.5	-0.3	-0.3	-0.3	-0.6	0.3	-0.2
High blood pressure (mother)	0.8	1.1	1.6	-1.1	1.3	1.1	1.1	0.8	0.7	1.0
Body mass index (BMI)	1.5	6.3	6.8	2.6	-2.6	-2.5	-2.3	-2.2	-2.6	-2.6
Impedance of leg (left)	0.2	1.1	1.7	-1.3	1.1	0.9	1.1	1.1	0.6	1.2
Leg predicted mass (left)	1.8	9.3	10.3	3.1	-3.1	-3.2	-3.2	-3.0	-2.7	-3.1
Trunk fat mass	3.1	13.2	15.1	3.4	-3.8	-3.8	-3.5	-3.2	-3.9	-3.8
Waist circumference	2.5	9.0	10.5	3.2	-3.2	-3.0	-2.9	-2.9	-2.7	-3.1
Number of incorrect matches in round	0.5	0.9	1.8	1.1	-0.6	-1.3	-1.2	-0.8	-0.5	-0.5
Past tobacco smoking	0.3	0.6	1.4	1.0	-0.3	-0.2	-0.7	-1.2	0.9	-0.3
Alcohol usually taken with meals	4.1	6.6	8.5	-2.0	2.9	2.3	2.3	2.9	2.5	2.8
Nervous feelings	0.3	0.6	1.3	0.1	1.1	0.8	0.6	0.5	1.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	0.1	-0.1	-0.6	-0.4	-0.2	-0.9	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.5	0.1	0.1	0.0	0.4	0.5	-0.7	-0.2
Hair/balding pattern: Pattern 2	1.5	1.9	3.2	1.8	-1.2	-1.5	-1.4	-1.3	-1.2	-1.1
Had menopause	0.1	0.1	0.2	-0.2	-0.1	0.4	0.4	0.4	0.1	0.0
Had other major operations	0.3	0.4	1.0	0.6	-0.1	-0.2	-0.6	-1.0	1.0	0.2
Forced vital capacity (FVC)	1.5	5.6	9.4	-1.6	2.6	2.6	2.3	1.8	3.1	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.7	0.6	-1.4	-1.4	-1.2	-0.9	-1.4	-1.6
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	3.6	1.3	-1.5	-1.9	-1.8	-1.9	-1.5	-1.4
Qualifications: None of the above	0.1	0.3	0.7	-0.2	0.6	0.4	-0.1	-0.3	0.8	0.8
Financial difficulties in last 2 years	0.4	0.5	1.1	1.0	-0.2	-0.6	-0.4	-1.1	-0.4	-0.7
Mouth/teeth dental problems	0.3	0.4	1.1	-0.8	0.6	0.1	0.4	1.1	-0.1	0.6
Heart attack	0.2	0.2	1.0	0.0	-0.5	-0.3	0.2	0.5	-1.0	-0.3
Allergy	1.0	2.3	4.3	-1.8	1.1	1.5	1.8	2.1	0.4	1.5
Pain all over the body in last month	1.7	1.8	3.1	1.2	-1.4	-1.4	-1.4	-1.8	-1.0	-0.9
Diabetes (self-reported)	1.4	2.2	2.8	1.6	-1.4	-1.5	-1.3	-1.6	-1.3	-1.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.7	-0.3	-0.4	-0.4	-0.6	-0.1	-0.5
Medication: Ramipril	0.4	0.5	0.8	-0.5	0.9	0.6	0.9	0.5	0.4	0.9
Medication: Simvastatin	0.1	0.2	0.7	0.1	-0.4	-0.2	-0.1	-0.3	-0.6	-0.8
Fluid intelligence score	0.2	0.4	0.9	-0.6	0.3	0.9	0.8	0.7	0.3	-0.2
Illnesses of siblings	2.6	3.7	4.5	-1.9	2.0	1.9	1.9	2.0	1.6	2.1
Neuroticism score	0.1	0.2	0.9	0.4	-0.1	-0.5	-0.2	-0.3	-0.9	-0.5
Weight	2.5	12.2	13.2	3.5	-3.6	-3.6	-3.5	-3.2	-3.4	-3.5
Impedance of arm (right)	0.3	1.6	2.3	0.9	-1.4	-1.5	-1.3	-1.0	-1.5	-1.2
Arm fat percentage (right)	2.8	11.2	13.9	3.1	-3.5	-3.5	-3.2	-2.7	-3.7	-3.6
Trunk fat-free mass	0.7	4.2	4.9	2.2	-2.0	-2.2	-2.2	-2.1	-1.7	-1.9
Hip circumference	2.1	9.2	10.2	3.0	-3.1	-3.2	-3.1	-3.0	-3.0	-3.0
Time employed in main current job	0.2	0.3	0.9	-0.7	-0.2	-0.4	0.2	0.4	-1.0	0.3
Alcohol intake versus 10 years previously	0.5	0.8	1.3	-1.0	0.9	1.1	0.9	1.0	0.6	0.6
Father’s age at death	0.2	0.2	1.2	0.2	0.3	0.0	-0.1	-0.2	1.1	0.4
Worrier / anxious feelings	2.4	4.5	5.8	-1.9	2.4	2.2	2.2	1.5	2.4	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.5	1.2	-1.1	-1.4	-1.0	-1.6	-1.5	-1.3
Falls in the last year	0.2	0.3	1.1	0.1	-0.6	-0.3	-0.1	0.2	-1.0	-0.7
Hair/balding pattern: Pattern 3	5.3	7.8	11.0	-3.3	2.6	3.0	3.1	2.9	1.7	2.6
Number of live births	0.1	0.1	0.4	0.2	0.2	0.2	0.1	-0.1	0.7	0.2
Forced expiratory volume in 1-second (FEV1)	2.0	6.8	8.5	-2.1	2.8	2.7	2.7	2.3	2.9	2.7
Pulse rate	3.4	5.7	6.5	2.5	-2.5	-2.5	-2.4	-2.4	-2.1	-2.1
Happiness	0.1	0.1	0.4	0.2	-0.2	-0.3	-0.1	-0.5	-0.6	0.0
Noisy workplace	0.5	0.6	1.0	0.7	-0.8	-0.7	-0.8	-0.6	-1.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.2	-1.1	1.2	1.3	1.4	1.5	1.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	0.1	0.5	0.5	0.5	0.4	0.7	0.7
Mouth/teeth dental problems: Dentures	2.2	3.8	5.6	2.4	-2.1	-1.7	-2.1	-2.0	-1.0	-2.0
Asthma	3.1	6.0	7.2	2.3	-2.6	-2.6	-2.7	-2.5	-1.7	-2.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.2	0.3	-1.7	-1.4	-1.3	-1.2	-1.9	-2.0
Medication: Cholesterol lowering	1.1	1.8	4.1	0.4	-1.4	-1.5	-1.1	-0.9	-2.0	-1.5
Depression (self-reported)	4.1	4.9	5.8	2.0	-2.1	-2.4	-2.4	-2.1	-2.2	-2.2
Medication: Lansoprazole	0.3	0.4	1.1	0.7	-0.2	-0.7	-1.1	-0.7	-0.1	-0.3
Prospective memory result	1.0	1.2	1.9	-0.6	1.3	1.1	1.1	0.7	1.4	1.3
Lung cancer (father)	0.1	0.1	0.2	0.3	-0.4	-0.1	-0.2	-0.3	0.2	-0.4
Illnesses of mother	0.1	0.1	0.2	0.1	-0.4	0.1	-0.2	0.5	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	7.3	-2.0	2.7	2.6	2.5	2.3	2.6	2.3
Pulse wave Arterial Stiffness index	1.6	1.9	4.6	0.1	-1.8	-1.1	-0.8	-0.8	-2.2	-1.8
Impedance of arm (left)	0.4	1.6	2.2	1.0	-1.3	-1.4	-1.2	-1.1	-1.5	-1.3
Arm fat mass (right)	2.7	11.2	13.3	3.2	-3.5	-3.5	-3.2	-2.8	-3.6	-3.5
Trunk predicted mass	0.8	4.4	5.2	2.3	-2.1	-2.3	-2.2	-2.1	-1.7	-1.9
Standing height	0.6	5.6	6.9	2.3	-2.3	-2.6	-2.6	-2.5	-2.0	-2.1
Length of working week for main job	0.3	0.3	1.2	-0.0	0.6	0.3	0.0	0.0	1.1	0.8
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.3	0.2	-0.3	-0.6	-0.3	0.4	0.4
Breastfed as a baby	1.4	1.7	2.8	-1.7	1.1	1.4	1.3	1.5	1.0	1.0
Tense / ‘highly strung’	0.0	0.1	0.3	0.5	0.0	-0.2	0.1	-0.0	-0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.6	4.7	1.9	-1.6	-2.2	-2.0	-1.9	-1.6	-2.0
Hair/balding pattern: Pattern 4	0.4	0.9	1.3	-0.9	1.1	0.9	0.8	0.7	1.1	0.8
Birth weight of first child	4.5	8.1	10.6	-1.9	3.2	3.0	3.0	2.5	3.2	3.0
Peak expiratory flow (PEF)	5.6	12.9	14.7	-3.2	3.7	3.5	3.7	3.5	3.8	3.7
Pulse wave reflection index	2.4	2.9	4.9	-2.2	1.7	1.9	1.9	1.5	1.0	1.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.5	0.0	-1.1	-1.3	-1.2	-0.5	-1.9	-1.1
Loud music exposure frequency	0.1	0.1	0.4	-0.2	0.2	0.1	0.1	0.6	0.1	0.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.2	-1.1	1.2	1.2	1.5	1.0	1.2	1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	0.7	-0.6	-0.2	-0.6	-1.2	0.3	-0.3
Blood clot in the leg (DVT)	1.1	1.4	4.8	1.1	-0.6	-1.0	-1.5	-2.2	0.3	-0.6
Medication: Paracetamol	2.3	3.8	5.5	2.1	-1.7	-1.9	-2.3	-2.1	-1.1	-2.1
Headache pain in last month	0.3	0.5	0.7	0.5	-0.6	-0.7	-0.6	-0.8	-0.8	-0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.0	-0.6	1.3	1.2	0.9	0.6	2.0	1.3
Glaucoma (self-reported)	0.8	0.9	1.3	-1.2	1.1	0.9	0.8	0.9	0.4	1.1
Gout (self-reported)	0.8	1.1	2.5	1.6	-0.8	-0.5	-0.8	-1.3	0.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.4	1.0	-0.9	-1.0	-0.8	-1.1	-0.8	-1.2
Medication: Amlodipine	0.4	0.6	1.2	-0.6	0.9	0.9	0.9	0.3	1.1	0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.5	0.8	-0.6	-1.2	-1.2	-1.0	-0.5	-0.9
Birth weight	1.0	2.1	2.8	-1.0	1.6	1.4	1.5	1.5	1.7	1.3
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.0	1.4	-0.4	-0.9	-0.9	-1.4	-0.2	-0.4
High blood pressure (siblings)	0.5	0.7	1.2	1.1	-0.8	-0.8	-0.5	-1.0	-0.6	-1.1
Forced vital capacity (FVC), Best measure	1.4	5.3	8.3	-1.5	2.6	2.6	2.3	1.8	2.9	2.0
Body fat percentage	2.8	10.9	13.4	3.0	-3.4	-3.5	-3.2	-2.8	-3.7	-3.5
Leg fat percentage (right)	1.9	7.0	8.0	2.6	-2.6	-2.8	-2.6	-2.4	-2.8	-2.6
Arm fat-free mass (right)	0.6	3.2	4.6	2.1	-1.6	-1.9	-1.9	-1.9	-1.2	-1.6
Exposure to tobacco smoke outside home	4.7	6.2	7.8	-2.5	2.8	2.4	2.2	2.1	2.6	2.7
Comparative body size at age 10	1.7	4.7	7.0	2.0	-2.3	-2.3	-1.8	-1.3	-2.6	-2.5
Number of full brothers	0.7	0.9	3.6	0.2	-1.0	-0.8	-0.4	-0.2	-1.9	-0.9
Worry too long after embarrassment	0.4	0.6	1.7	0.0	-0.9	-0.9	-0.6	-0.2	-1.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	6.4	8.3	10.2	2.6	-2.9	-3.2	-3.0	-2.6	-3.1	-2.8
Wheeze or whistling in the chest in last year	6.7	11.9	13.7	3.4	-3.7	-3.4	-3.5	-3.5	-3.0	-3.6
Number of children fathered	0.2	0.2	1.6	1.2	-0.0	-0.2	-0.3	-0.1	-0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	0.1	1.1	0.6	0.7	0.3	1.2	0.9
Age at first live birth	0.5	0.9	2.4	-0.9	0.7	0.8	1.1	1.5	0.0	0.7
Pulse wave peak to peak time	1.4	1.6	3.9	-0.1	1.6	1.0	0.8	0.7	2.0	1.6
Health satisfaction	2.8	3.6	4.2	1.9	-1.7	-2.0	-1.9	-2.1	-1.5	-2.0
Shortness of breath walking on level ground	9.0	10.7	14.1	3.0	-3.2	-3.7	-3.8	-3.4	-2.7	-3.1
Qualifications: College or University degree	0.3	0.9	2.6	-1.0	0.1	0.2	0.9	1.6	-1.2	-0.1
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.6	0.7	0.3	0.5	0.5	0.7	0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.1	1.1	-1.0	-0.6	-0.5	-0.8	-0.8	-0.8
Emphysema/chronic bronchitis	0.1	0.1	0.5	-0.0	-0.0	0.1	0.1	0.5	-0.7	-0.0
Medication for pain relief, constipation, heartburn	1.3	2.2	4.4	-1.1	1.3	1.3	1.3	1.2	1.7	2.1
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.0	0.2	0.2	0.5	0.3	-0.3	-0.1
Medication: Blood pressure	0.2	0.4	1.4	0.3	-0.5	-0.6	-0.4	-0.2	-1.2	-0.3
Angina (self-reported)	0.1	0.2	0.7	-0.3	0.4	0.3	0.5	0.8	-0.1	0.1
Migraine (self-reported)	3.6	4.4	6.5	-2.5	2.1	2.1	2.2	2.3	1.4	2.0
Medication: Ibuprofen	1.0	1.2	2.7	0.4	-1.2	-0.8	-0.8	-0.9	-1.4	-1.6
Medication: Allopurinol	0.8	1.1	2.1	1.0	-1.0	-0.8	-1.0	-1.3	-0.6	-1.5
Medication: Omeprazole	0.7	0.8	1.6	-0.4	0.9	1.3	1.1	0.6	1.2	0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.5	-0.1	0.4	0.3	0.2	-0.4	0.1
Mean time to correctly identify matches	0.4	0.8	1.3	-0.8	1.0	1.1	0.8	0.9	0.9	0.6
Heart disease (mother)	1.4	1.7	2.5	-0.8	1.4	1.3	1.2	1.0	1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.6	-0.6	-0.4	-0.5	-0.1	-0.5	-0.2
Whole body fat mass	2.8	11.7	13.8	3.2	-3.6	-3.6	-3.3	-3.0	-3.7	-3.6
Leg fat mass (right)	2.7	10.6	11.8	3.2	-3.3	-3.4	-3.2	-3.0	-3.2	-3.3
Arm predicted mass (right)	0.7	3.8	4.9	2.2	-1.8	-2.1	-2.2	-2.1	-1.4	-1.8
Pulse rate, automated reading	1.5	5.0	6.0	2.0	-2.4	-2.3	-2.1	-2.3	-2.5	-2.1
Alcohol intake frequency.	0.1	0.1	0.6	-0.0	-0.0	-0.4	-0.3	-0.2	-0.8	-0.0
Comparative height size at age 10	1.7	9.2	11.4	3.2	-3.0	-3.3	-3.4	-3.0	-2.7	-2.5
Number of full sisters	0.8	1.0	1.8	-0.9	1.0	0.9	1.0	1.1	0.4	1.3
Suffer from ‘nerves’	0.1	0.2	0.6	0.8	-0.0	-0.4	-0.5	-0.5	0.1	-0.2
Overall health rating	4.9	10.6	12.9	3.1	-3.2	-3.6	-3.2	-3.6	-2.9	-3.1
Chest pain or discomfort	0.6	0.8	2.0	0.5	-1.0	-0.6	-0.8	-0.5	-1.4	-1.1
Had major operations	0.7	0.8	2.1	1.4	-0.5	-0.8	-0.9	-1.3	-0.3	-0.7
Age at last live birth	0.2	0.3	0.8	-0.4	0.2	0.3	0.8	0.9	-0.5	-0.1
Family relationship satisfaction	2.0	2.5	4.0	1.5	-1.3	-2.0	-1.9	-1.6	-1.5	-1.0
Leg pain on walking	3.8	4.7	6.0	1.7	-2.1	-2.5	-2.2	-2.2	-2.3	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.0	1.3	-1.1	-0.7	-0.6	-1.0	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	1.7	2.0	4.0	-0.4	2.0	1.4	1.1	0.4	1.8	1.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.8	-0.9	-0.2	-0.4	-0.5	-0.5	-0.8
Medication: Aspirin	0.3	0.3	1.0	0.7	-0.2	-0.6	-0.3	-0.1	-1.0	-0.6
Supplements: Vitamin C	0.9	1.0	2.0	-0.9	1.3	0.7	1.0	0.9	0.8	1.4
Knee pain experienced in last month	0.6	0.9	1.8	1.0	-0.9	-1.1	-1.0	-0.4	-1.4	-0.7
Hypertension (Self-reported)	0.1	0.2	0.6	0.3	-0.3	-0.0	0.0	-0.4	-0.8	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	5.2	-1.8	1.3	2.3	2.2	2.1	1.0	0.9
Illnesses of father: Heart disease	0.1	0.1	0.4	0.6	0.3	-0.3	-0.3	-0.1	0.3	-0.3
Illnesses of siblings: Diabetes	4.1	5.1	8.4	2.2	-2.0	-2.4	-2.6	-2.9	-1.0	-2.2
Smoking status: Previous	0.4	0.7	1.6	-1.1	0.3	0.2	0.8	1.3	-0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	4.3	1.4	-1.2	-2.1	-1.9	-1.4	-1.5	-1.1
Whole body fat-free mass	1.0	5.6	6.6	2.4	-2.3	-2.6	-2.5	-2.4	-2.0	-2.3
Leg fat-free mass (right)	1.2	6.7	7.5	2.5	-2.6	-2.7	-2.7	-2.5	-2.4	-2.6
Arm fat percentage (left)	2.9	11.6	14.2	3.2	-3.6	-3.5	-3.2	-2.8	-3.8	-3.7
Average weekly red wine intake	0.3	0.5	1.2	-0.0	0.8	0.3	0.3	0.8	0.8	1.1
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.6	-1.2	0.4	0.2	0.5	0.9	0.0	0.5
Mood swings	0.1	0.2	0.5	0.6	-0.1	-0.4	-0.3	-0.5	-0.7	-0.4
Loneliness, isolation	0.3	0.4	0.9	0.4	-0.7	-0.5	-0.7	-0.3	-0.9	-0.8
Long-standing illness, disability or infirmity	2.4	3.6	5.3	2.0	-1.6	-2.3	-2.1	-2.1	-1.6	-1.5
Ever had bowel cancer screening	0.7	0.8	1.5	0.3	-1.0	-0.9	-1.2	-0.9	-0.8	-0.8
Diabetes diagnosed by doctor	2.3	3.8	4.8	2.0	-1.9	-1.9	-1.8	-2.1	-1.7	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	4.2	4.5	5.7	2.1	-1.9	-2.4	-1.9	-2.3	-2.3	-1.8
Friendships satisfaction	0.2	0.2	0.6	-0.7	0.3	0.2	0.3	0.8	-0.2	0.6
Qualifications: nursing, teaching	1.5	2.4	3.5	-1.4	1.6	1.7	1.9	1.8	1.1	1.1
Commuting to job workplace: Walk	0.3	0.3	1.0	-0.7	0.1	0.4	0.5	1.0	-0.0	-0.2
Eye problems/disorders: Cataract	1.2	1.3	2.1	1.4	-1.2	-0.8	-1.1	-1.3	-0.5	-1.5
Mouth/teeth dental problems: Mouth ulcers	5.9	9.4	11.4	-2.8	3.3	3.4	3.0	2.5	3.4	3.0
Medication for cholesterol	1.4	2.1	4.3	2.1	-1.2	-1.5	-1.7	-1.7	-0.4	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.1	1.7	-0.6	-0.9	-1.3	-1.8	0.9	-0.6
Back pain experienced in last month	4.6	6.6	8.0	2.8	-2.4	-2.8	-2.8	-2.6	-2.1	-2.4
Mineral and other dietary supplements	0.8	1.1	1.9	-1.0	1.0	1.4	1.1	1.1	0.8	1.0
Breast cancer (self-reported)	0.9	1.1	3.1	-0.7	1.1	0.8	0.6	0.5	1.8	1.2
Asthma (self-reported)	3.4	6.7	8.4	2.6	-2.7	-2.8	-2.9	-2.7	-1.6	-2.6
Osteoporosis (self-reported)	0.4	0.4	0.6	0.8	-0.8	-0.6	-0.8	-0.5	-0.7	-0.6
Osteoarthritis (self-reported)	0.6	0.8	1.5	-0.8	0.7	1.0	1.2	1.2	0.1	0.5
Medication: Aspirin	0.2	0.3	1.1	0.5	-0.2	-0.4	-0.1	0.0	-1.0	-0.6
Medication: Gliclazide	0.9	1.0	1.4	1.2	-0.9	-0.9	-1.0	-0.9	-1.0	-1.0
Illnesses of father: None of the above (group 1)	0.8	0.9	1.4	-0.9	0.9	1.0	0.9	1.0	0.8	1.2
Smoking status: Current	3.8	6.1	9.4	3.1	-2.3	-2.2	-2.3	-2.9	-1.7	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.2	6.9	8.9	-2.2	2.7	2.9	3.0	2.6	2.4	2.5
Whole body water mass	1.0	5.6	6.5	2.5	-2.3	-2.5	-2.5	-2.4	-2.0	-2.3
Leg predicted mass (right)	1.3	6.7	7.6	2.5	-2.6	-2.8	-2.7	-2.5	-2.4	-2.6
Arm fat mass (left)	3.0	12.4	13.8	3.5	-3.7	-3.7	-3.4	-3.0	-3.7	-3.7
Number of self-reported non-cancer illnesses	0.7	1.2	1.9	1.4	-0.8	-1.2	-0.9	-1.4	-0.7	-1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.7	-0.2	-0.1	-0.3	-0.0	0.4	-0.8	-0.4
Miserableness	1.7	2.9	4.2	1.4	-1.6	-1.8	-1.5	-1.7	-2.0	-1.8
Guilty feelings	0.4	0.6	0.8	0.8	-0.6	-0.9	-0.9	-0.6	-0.9	-0.9
Wears glasses or contact lenses	4.3	5.0	7.8	-2.8	1.8	2.4	2.6	2.6	1.4	1.6
Ever taken oral contraceptive pill	4.4	4.9	7.1	1.7	-2.5	-2.4	-2.1	-1.1	-2.7	-2.5
Hearing aid user	0.4	0.4	0.8	0.8	-0.5	-0.6	-0.9	-0.5	-0.4	-0.7
Mother’s age at death	0.4	0.5	1.6	1.2	-0.5	-0.6	-0.8	-0.5	0.1	-0.6
Financial situation satisfaction	1.2	1.5	4.5	1.6	-0.4	-1.2	-1.4	-2.1	0.1	-0.4
Tinnitus: Yes, now most or all of the time	4.4	5.2	8.0	2.4	-2.0	-2.8	-2.6	-2.4	-1.9	-1.6
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.3	0.1	0.3	0.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	-1.0	0.6	0.6	0.7	0.6	-0.2	0.6
Medication: Blood pressure	1.0	2.0	2.8	-1.7	1.4	1.5	1.7	1.4	0.8	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.2	0.4	-0.7	-0.3	0.1	0.0	-1.5	-0.8
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.5	0.1	0.3	-0.1	0.0	-0.5	0.7	0.4
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.5	-0.0	0.0	0.5	0.0	-0.8	-0.3
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.2	0.0	-0.1	-0.1	-0.1	-0.2	0.0
Medication: Paracetamol	4.4	6.8	9.2	3.0	-2.4	-2.5	-2.9	-2.9	-1.4	-2.8
Medication: Lisinopril	0.4	0.5	1.3	0.6	-0.5	-0.3	-0.3	-0.4	-1.0	-1.1
Medication: Atorvastatin	0.1	0.1	0.6	-0.4	-0.1	-0.3	-0.0	0.1	-0.8	-0.1
Illnesses of father: High blood pressure	0.3	0.4	1.0	-0.6	0.8	0.5	0.6	1.0	0.1	0.6
Alcohol drinker status: Never	0.6	0.7	1.5	-0.9	0.6	1.0	1.2	0.8	-0.0	0.9
Ever smoked	0.2	0.3	0.6	-0.7	0.4	0.6	0.8	0.8	-0.1	0.3
Basal metabolic rate	1.4	7.9	8.9	2.9	-2.8	-3.0	-2.9	-2.8	-2.5	-2.7
Leg fat percentage (left)	1.3	4.8	6.6	2.0	-2.2	-2.3	-2.0	-1.8	-2.6	-2.3
Arm fat-free mass (left)	0.9	4.3	5.2	2.2	-2.0	-2.3	-2.2	-2.0	-1.8	-1.9
Number of operations (self-reported)	0.7	1.0	1.9	1.2	-0.7	-1.1	-1.1	-1.4	-0.3	-0.8
Average weekly beer plus cider intake	1.6	2.3	4.5	2.1	-1.4	-1.2	-1.6	-1.8	-0.2	-1.5
Irritability	0.8	1.4	1.9	1.1	-1.0	-1.3	-1.0	-1.3	-1.4	-1.1
Risk taking	0.2	0.3	0.7	0.2	-0.7	-0.6	-0.6	-0.4	-0.8	-0.6
Ever had prostate specific antigen (PSA) test	2.8	3.3	6.0	2.5	-1.5	-1.8	-1.9	-2.1	-1.0	-1.5
Fractured/broken bones in last 5 years	1.5	1.9	3.9	2.0	-1.2	-1.4	-1.1	-1.2	-0.6	-1.7
Age started oral contraceptive pill	0.3	0.4	1.3	0.3	0.7	0.2	0.3	-0.6	1.1	0.5
Diastolic blood pressure, automated reading	0.6	1.9	2.3	1.4	-1.4	-1.3	-1.3	-1.3	-1.5	-1.4
Ever depressed for a whole week	2.5	3.1	4.3	1.6	-1.7	-2.0	-2.1	-1.9	-1.5	-1.4
Unable to work because of sickness or disability	0.5	0.7	1.6	1.1	-0.5	-0.8	-1.0	-1.3	-0.0	-0.2
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.3	-0.7	-0.3	0.1	-0.1	-0.6	-0.6
Myopia	1.0	1.4	3.4	-0.7	1.3	0.8	0.7	0.4	1.8	1.8
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.0	0.0	-0.1	-0.3	0.1	0.6	0.3
Cholesterol lowering medication	2.3	3.4	4.9	-1.9	2.0	2.1	2.2	1.9	1.2	1.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.6	0.4	0.4	0.3	0.3	-0.1	0.8	-0.3
Pain experienced in last month	0.6	1.0	2.4	-0.4	1.0	1.2	0.8	0.5	1.6	1.1
Supplements: Calcium	1.5	1.7	2.1	1.4	-1.2	-1.5	-1.1	-1.4	-1.1	-1.3
Basal cell carcinoma (self-reported)	0.9	1.1	3.6	-0.6	0.9	0.9	0.8	0.4	1.9	1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.3	0.1	-0.6	-0.4	0.0	0.4	-1.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.4	1.0	-0.6	-0.9	-1.4	-2.1	0.5	-0.5
Heart disease (siblings)	2.2	2.7	3.8	0.8	-1.9	-1.7	-1.8	-1.3	-1.9	-1.9
Alcohol drinker status: Previous	1.6	1.8	3.3	1.6	-1.1	-1.2	-1.4	-1.8	-0.3	-1.4
Pack years of smoking	2.2	3.3	4.5	1.5	-2.1	-1.7	-1.7	-1.9	-1.7	-1.9
Impedance of whole body	0.0	0.1	0.4	-0.0	-0.3	-0.3	-0.2	-0.1	-0.6	-0.3
Leg fat mass (left)	2.3	9.0	9.9	2.9	-3.1	-3.1	-2.9	-2.8	-3.0	-3.1
Arm predicted mass (left)	0.9	4.5	5.5	2.3	-2.0	-2.4	-2.3	-2.0	-2.0	-1.9