Hub : Genes

JMY

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0520 0.0200 6.6e-04 0.057 0.017 0.046 0.029 0.048 1.9e-07 2.9e-03 2.4e-06 1.7e-04 1.6e-06
2 GTEx Testis 0.1060 0.0470 6.1e-03 0.118 NA 0.063 NA 0.096 6.9e-06 NA 9.4e-04 NA 4.9e-05
3 NTR Blood 0.0166 0.0072 3.3e-03 0.012 0.004 0.002 0.004 0.007 6.6e-05 1.6e-02 6.6e-02 1.8e-02 2.5e-03
4 YFS Blood 0.0453 0.0108 1.2e-14 0.069 0.044 0.062 0.060 0.066 1.5e-21 3.4e-14 2.1e-19 5.8e-19 1.3e-20
5 TCGA Colon Adenocarcinoma 0.0640 0.0320 7.7e-05 0.091 0.095 0.083 NA 0.087 5.9e-06 4.0e-06 1.6e-05 NA 9.7e-06
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0529 0.0361 7.8e-04 0.026 0.023 0.021 NA 0.023 5.6e-04 1.0e-03 1.9e-03 NA 1.2e-03
7 TCGA Thyroid Carcinoma 0.0510 0.0300 2.9e-04 0.044 0.033 0.035 NA 0.032 3.8e-05 3.5e-04 2.1e-04 NA 3.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.1 0.2 0.7 0.0 -0.5 0.0 -0.0 0.4 -0.2 -0.8
Bipolar Disorder or Schizophrenia 0.8 1.9 3.6 -1.9 1.3 1.2 1.3 1.3 1.1 1.2
Depressed Affect (Nagel 2018) 0.2 0.5 1.4 0.4 -0.3 -0.7 -0.6 -0.8 -1.2 -0.6
Depression (Nagel 2018) 4.9 7.4 10.2 2.4 -2.6 -2.8 -2.5 -2.7 -3.2 -2.9
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.2 -0.7 1.1 1.4 1.5 0.7 1.4 0.9
Neuroticism (Nagel 2018) 0.0 0.1 0.1 -0.0 0.4 -0.1 -0.1 -0.3 -0.4 -0.1
Schizophrenia (2018) 1.7 3.6 6.1 -2.5 2.1 1.6 1.8 1.4 1.6 2.2
Schizophrenia vs Biploar Disorder 3.5 4.6 5.4 -2.2 2.3 2.0 2.2 2.0 1.9 2.3
Worry (Nagel 2018) 1.0 2.0 3.4 -0.9 1.8 1.6 1.5 1.0 1.5 1.3
Alzheimer’s Disease (in mother) 1.2 1.4 2.0 0.7 -1.4 -1.3 -1.2 -0.9 -1.2 -1.3
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.3 -0.2 -0.1 -0.2 -0.4 -0.3 -0.3
Alzheimer’s Disease (including proxy) 2.1 3.0 4.0 1.5 -1.8 -1.7 -1.8 -2.0 -1.4 -1.9
Crohns Disease (2017) 0.3 0.6 1.3 0.6 -0.8 -1.1 -0.8 -0.8 -0.7 -0.6
Irritable Bowel Disease (IBD) 0.7 1.8 2.3 0.9 -1.5 -1.5 -1.5 -1.4 -1.1 -1.2
Ulcerative Colitis (UC) 0.9 1.7 2.3 0.9 -1.5 -1.3 -1.5 -1.4 -1.0 -1.3
Major Depression (MDD) 3.9 4.7 6.1 1.5 -2.4 -2.5 -1.9 -2.2 -2.1 -2.5
Reaction Time 1.1 2.1 3.0 -1.0 1.7 1.6 1.4 1.2 1.7 1.3
Verbal and Numeric Reasoning (VNR) 1.4 3.4 4.3 -1.9 1.7 2.1 2.0 1.8 1.9 1.3
Breast Cancer 0.8 1.9 2.8 1.7 -1.1 -1.4 -1.5 -1.6 -0.7 -1.4
Ovarian Cancer 0.6 0.8 1.8 1.4 -0.4 -0.6 -1.0 -1.3 0.6 -0.3
Prostate Cancer 0.2 0.2 0.9 -0.6 -0.5 -0.4 -0.2 0.3 -0.9 0.1
Age at First Birth 2.1 3.0 3.5 -1.9 1.9 1.7 1.9 1.6 1.6 1.7
Bipolar Disorder (2011) 0.2 0.2 0.4 -0.4 0.2 0.5 0.4 0.6 0.3 -0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 0.3 -0.4 -0.2 -0.3 -0.1 -0.1 -0.3
Coronary Artery Disease (CAD) 0.1 0.1 0.3 -0.3 -0.0 0.3 0.6 0.0 -0.1 0.3
Crohns Disease (2012) 0.0 0.0 0.2 0.1 -0.2 -0.1 -0.1 -0.3 0.4 -0.1
Mean Putamen Volume 2.1 2.4 3.6 1.2 -1.9 -1.8 -1.5 -1.3 -1.1 -1.8
Fasting Glucose 0.2 0.2 0.7 -0.1 -0.5 -0.3 -0.2 0.1 -0.8 -0.5
HbA1C 0.6 0.6 1.2 -1.1 0.9 0.5 0.6 0.7 0.9 0.8
HDL Cholesterol 3.6 6.0 9.4 -1.8 2.6 2.3 2.5 2.0 3.1 2.5
LDL Cholesterol 2.1 3.4 4.4 -1.6 1.8 2.1 2.0 1.8 1.8 1.6
Lupus 0.0 0.1 0.2 -0.5 0.0 -0.2 0.1 0.1 -0.4 0.1
Neuroticism (2016) 1.6 2.3 3.5 1.2 -1.5 -1.6 -1.7 -1.0 -1.9 -1.6
Primary Biliary Cirrhosis 2.2 3.2 6.2 1.1 -2.1 -1.5 -1.1 -2.1 -1.7 -2.5
Rheumatoid Arthritis 1.8 2.4 4.5 -2.1 1.3 1.5 1.6 1.4 1.3 1.4
Schizophrenia (2014) 1.3 2.9 5.3 -2.3 1.8 1.4 1.5 1.5 1.6 1.7
Triglycerides 1.3 2.1 2.8 1.0 -1.7 -1.4 -1.5 -1.5 -1.3 -1.6
Type 2 Diabetes (T2D) (2012) 4.9 5.7 8.6 1.9 -2.9 -2.8 -1.9 -1.8 -2.5 -2.6
Ulcerative Colitis 2.5 3.6 5.0 1.3 -2.2 -1.8 -2.2 -2.1 -1.4 -2.0
Blood Eosinophil Count 0.0 0.2 0.4 -0.1 -0.2 0.5 0.7 0.3 -0.3 -0.5
Blood Platelet Count 1.2 13.3 16.0 -3.0 3.9 3.8 4.0 3.5 3.6 3.8
Blood Red Count 0.1 0.6 2.2 -0.1 -0.8 0.3 0.1 0.2 -1.5 -1.1
Blood White Count 2.5 18.7 23.5 4.2 -4.5 -4.3 -4.0 -3.6 -4.7 -4.8
Heel T-Score 1.7 13.3 20.0 3.7 -3.7 -3.5 -3.4 -3.7 -2.8 -4.5
BMI 1.4 8.0 10.8 2.5 -3.2 -2.6 -2.5 -2.2 -3.3 -3.2
Height 0.7 12.9 17.3 3.1 -3.6 -3.9 -4.2 -3.9 -2.9 -3.3
Waist Hip Ratio (WHR) 0.2 0.8 1.6 0.8 -1.3 -0.8 -0.6 -0.2 -1.0 -1.2
Systolic Blood Pressure 0.1 0.7 1.0 0.8 -0.8 -0.9 -0.9 -0.7 -1.0 -0.8
Smoking Status 2.2 5.3 7.4 2.4 -2.3 -2.2 -1.8 -2.2 -2.5 -2.7
Allergy or Eczema 0.9 2.3 5.1 2.2 -0.7 -1.3 -1.7 -2.2 0.3 -1.0
Cardiovascular Disease 0.6 2.1 4.4 0.9 -1.6 -1.3 -0.9 -1.2 -2.1 -1.7
Hypothyroidism (self reported) 0.2 0.5 1.5 1.2 -0.4 -0.7 -0.4 -1.0 -0.3 -0.6
Respiratory disease 4.8 10.8 14.2 2.7 -3.6 -3.3 -3.2 -3.2 -3.1 -3.8
Type 2 Diabetes (T2D) (2018) 5.1 9.5 13.0 2.2 -3.4 -3.1 -2.9 -2.7 -3.6 -3.6
Lung FEV1/FVC ratio 0.2 0.9 1.8 -1.3 -0.4 0.9 1.3 1.4 -0.5 0.3
Lung FVC 6.3 31.8 39.0 -4.5 6.1 6.2 6.0 5.2 5.9 5.4
Neuroticism 0.0 0.1 0.5 -0.4 0.2 0.0 0.3 0.1 -0.7 -0.1
Chronotype (morning person) 0.1 0.2 0.5 -0.6 -0.2 -0.1 0.2 0.7 -0.3 -0.1
Hair Pigment 0.0 0.1 0.3 0.1 -0.2 -0.1 -0.2 -0.5 -0.4 -0.4
Tanning 0.3 3.1 4.1 2.0 -1.8 -1.6 -1.6 -1.9 -1.4 -1.9
Hand grip strength (left) 0.2 0.4 0.7 -0.6 0.8 0.6 0.6 0.3 0.8 0.8
Number of treatments/medications taken 1.4 2.5 3.7 1.4 -1.3 -1.7 -1.6 -1.6 -1.4 -1.9
Average weekly spirits intake 2.6 3.3 5.2 2.3 -1.7 -1.5 -2.0 -1.8 -1.2 -2.0
Sensitivity / hurt feelings 0.0 0.1 0.2 0.1 0.5 0.1 0.1 0.4 -0.1 -0.1
Frequency of depressed mood in last 2 weeks 2.9 4.0 6.1 1.9 -1.9 -2.1 -1.6 -1.7 -2.5 -2.2
Hearing difficulty/problems: Yes 0.2 0.3 1.5 -0.4 -0.5 -0.1 -0.2 0.2 -1.2 -0.5
Relative age of first facial hair 0.4 0.8 2.1 1.2 -0.6 -0.1 -0.6 -1.5 1.0 -0.7
Other serious medical condition/disability diagnosed by doctor 2.7 3.5 5.2 2.2 -1.6 -2.1 -2.3 -2.3 -1.0 -1.3
Ever used hormone-replacement therapy (HRT) 2.1 2.7 3.4 1.6 -1.8 -1.7 -1.6 -1.3 -1.5 -1.8
Ever had hysterectomy (womb removed) 1.4 1.5 3.1 1.1 -1.3 -1.0 -1.1 -1.3 -0.9 -1.8
Systolic blood pressure, automated reading 0.3 1.0 1.8 0.9 -1.0 -1.0 -1.0 -0.5 -1.3 -0.9
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 1.4 1.0 -0.9 -1.1 -1.0 -0.3 -1.2 -1.0
Angina 0.3 0.3 0.9 -0.5 0.6 0.5 0.7 1.0 0.0 0.3
Medication for hormone replacement therapy 1.0 1.1 2.6 -0.2 -1.2 -1.2 -1.1 -0.1 -1.6 -1.0
Vitamin and mineral supplements 2.2 3.0 4.3 -1.5 1.8 1.9 1.4 1.8 1.7 2.1
Supplements: Zinc 1.3 1.4 2.1 1.5 -1.2 -1.3 -1.1 -1.3 -0.8 -1.0
Medication: Co-codamol 1.0 1.2 1.6 0.7 -1.0 -1.3 -1.2 -1.1 -1.2 -0.8
Medication: Metformin 5.1 7.2 8.8 2.7 -2.7 -2.7 -2.5 -2.8 -2.5 -3.0
Diabetes (father) 0.6 0.8 2.1 0.8 -0.6 -1.0 -1.5 -1.1 -0.1 -0.3
Diabetes (mother) 9.0 11.4 13.4 3.5 -3.2 -3.7 -3.3 -3.5 -3.0 -3.5
Severe depression (siblings) 2.8 3.2 5.9 2.4 -1.6 -1.7 -1.4 -1.6 -1.6 -1.9
Pack years adult smoking proportion 2.5 3.8 5.2 1.7 -2.3 -1.8 -1.8 -2.2 -1.7 -2.1
Impedance of leg (right) 0.0 0.2 0.5 -0.5 0.6 0.3 0.3 0.3 0.4 0.7
Leg fat-free mass (left) 1.6 8.7 9.6 3.0 -3.0 -3.1 -3.1 -2.9 -2.6 -3.0
Trunk fat percentage 2.9 11.8 15.4 3.1 -3.6 -3.5 -3.3 -2.8 -3.9 -3.7
Hand grip strength (right) 0.5 1.3 2.0 -1.4 1.3 1.0 1.0 0.9 1.2 1.2
Townsend deprivation index at recruitment 5.5 7.7 8.7 2.7 -2.8 -2.8 -2.5 -2.7 -3.0 -2.9
Current tobacco smoking 5.4 8.9 12.9 3.6 -2.8 -2.7 -2.7 -3.6 -2.0 -3.2
Average weekly fortified wine intake 0.1 0.1 0.7 -0.2 -0.2 -0.3 -0.1 0.4 -0.8 -0.2
Maternal smoking around birth 0.4 0.6 1.4 0.9 -0.4 -1.0 -0.8 -1.2 -0.1 -0.5
Fed-up feelings 0.4 0.8 2.1 0.6 -0.4 -1.0 -0.9 -1.0 -1.5 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 8.5 11.3 15.3 3.3 -3.1 -3.5 -3.0 -3.1 -3.9 -3.4
Relative age voice broke 2.5 3.7 5.2 2.0 -2.1 -1.6 -2.0 -2.1 -1.2 -2.3
Taking other prescription medications 1.5 2.3 3.8 1.5 -1.0 -1.6 -1.6 -2.0 -1.0 -1.7
Age when periods started (menarche) 0.6 1.5 2.2 -1.0 1.3 1.5 1.5 1.3 1.0 1.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.2 -0.7 -0.3 -0.4 0.2 -0.7 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 4.9 0.9 -2.1 -2.0 -1.9 -1.3 -2.2 -2.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.5 0.1 0.4 0.5 0.7 -0.2 0.2
Qualifications: CSEs or equivalent 0.6 0.8 1.5 -1.2 0.3 1.0 1.0 1.1 -0.6 0.4
Serious illness, injury or assault to yourself 0.2 0.2 0.6 0.6 -0.2 -0.8 -0.5 -0.5 -0.2 -0.2
High blood pressure 0.0 0.1 0.3 0.2 -0.2 0.1 0.1 -0.3 -0.6 -0.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.0 1.4 -0.4 -0.7 -1.0 -1.4 0.2 -0.6
Multivitamins +/- minerals 1.6 2.0 2.9 1.6 -1.4 -1.4 -1.2 -1.6 -0.8 -1.7
Stomach or abdominal pain in last month 0.1 0.2 0.7 -0.6 -0.0 -0.1 -0.2 0.4 -0.8 0.2
Supplements: Glucosamine 1.0 1.3 2.2 0.9 -1.5 -1.2 -0.7 -0.5 -1.4 -1.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.4 0.8 -0.7 -1.1 -1.1 -1.2 -0.5 -0.7
Medication: Atenolol 1.4 1.7 2.9 -1.6 1.1 1.3 1.6 1.7 0.1 1.0
Medication: Levothyroxine sodium 0.0 0.1 0.3 0.0 0.0 -0.1 -0.2 -0.6 0.3 -0.3
Sitting height 1.1 7.5 8.5 2.6 -2.6 -2.8 -2.9 -2.9 -2.4 -2.9
Chronic bronchitis/emphysema (father) 0.1 0.2 0.4 0.5 -0.3 -0.3 -0.3 -0.6 0.3 -0.2
High blood pressure (mother) 0.8 1.1 1.6 -1.1 1.3 1.1 1.1 0.8 0.7 1.0
Body mass index (BMI) 1.5 6.3 6.8 2.6 -2.6 -2.5 -2.3 -2.2 -2.6 -2.6
Impedance of leg (left) 0.2 1.1 1.7 -1.3 1.1 0.9 1.1 1.1 0.6 1.2
Leg predicted mass (left) 1.8 9.3 10.3 3.1 -3.1 -3.2 -3.2 -3.0 -2.7 -3.1
Trunk fat mass 3.1 13.2 15.1 3.4 -3.8 -3.8 -3.5 -3.2 -3.9 -3.8
Waist circumference 2.5 9.0 10.5 3.2 -3.2 -3.0 -2.9 -2.9 -2.7 -3.1
Number of incorrect matches in round 0.5 0.9 1.8 1.1 -0.6 -1.3 -1.2 -0.8 -0.5 -0.5
Past tobacco smoking 0.3 0.6 1.4 1.0 -0.3 -0.2 -0.7 -1.2 0.9 -0.3
Alcohol usually taken with meals 4.1 6.6 8.5 -2.0 2.9 2.3 2.3 2.9 2.5 2.8
Nervous feelings 0.3 0.6 1.3 0.1 1.1 0.8 0.6 0.5 1.0 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.8 0.1 -0.1 -0.6 -0.4 -0.2 -0.9 -0.4
Hearing difficulty/problems with background noise 0.1 0.1 0.5 0.1 0.1 0.0 0.4 0.5 -0.7 -0.2
Hair/balding pattern: Pattern 2 1.5 1.9 3.2 1.8 -1.2 -1.5 -1.4 -1.3 -1.2 -1.1
Had menopause 0.1 0.1 0.2 -0.2 -0.1 0.4 0.4 0.4 0.1 0.0
Had other major operations 0.3 0.4 1.0 0.6 -0.1 -0.2 -0.6 -1.0 1.0 0.2
Forced vital capacity (FVC) 1.5 5.6 9.4 -1.6 2.6 2.6 2.3 1.8 3.1 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 2.7 0.6 -1.4 -1.4 -1.2 -0.9 -1.4 -1.6
Ever unenthusiastic/disinterested for a whole week 2.1 2.6 3.6 1.3 -1.5 -1.9 -1.8 -1.9 -1.5 -1.4
Qualifications: None of the above 0.1 0.3 0.7 -0.2 0.6 0.4 -0.1 -0.3 0.8 0.8
Financial difficulties in last 2 years 0.4 0.5 1.1 1.0 -0.2 -0.6 -0.4 -1.1 -0.4 -0.7
Mouth/teeth dental problems 0.3 0.4 1.1 -0.8 0.6 0.1 0.4 1.1 -0.1 0.6
Heart attack 0.2 0.2 1.0 0.0 -0.5 -0.3 0.2 0.5 -1.0 -0.3
Allergy 1.0 2.3 4.3 -1.8 1.1 1.5 1.8 2.1 0.4 1.5
Pain all over the body in last month 1.7 1.8 3.1 1.2 -1.4 -1.4 -1.4 -1.8 -1.0 -0.9
Diabetes (self-reported) 1.4 2.2 2.8 1.6 -1.4 -1.5 -1.3 -1.6 -1.3 -1.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 0.7 -0.3 -0.4 -0.4 -0.6 -0.1 -0.5
Medication: Ramipril 0.4 0.5 0.8 -0.5 0.9 0.6 0.9 0.5 0.4 0.9
Medication: Simvastatin 0.1 0.2 0.7 0.1 -0.4 -0.2 -0.1 -0.3 -0.6 -0.8
Fluid intelligence score 0.2 0.4 0.9 -0.6 0.3 0.9 0.8 0.7 0.3 -0.2
Illnesses of siblings 2.6 3.7 4.5 -1.9 2.0 1.9 1.9 2.0 1.6 2.1
Neuroticism score 0.1 0.2 0.9 0.4 -0.1 -0.5 -0.2 -0.3 -0.9 -0.5
Weight 2.5 12.2 13.2 3.5 -3.6 -3.6 -3.5 -3.2 -3.4 -3.5
Impedance of arm (right) 0.3 1.6 2.3 0.9 -1.4 -1.5 -1.3 -1.0 -1.5 -1.2
Arm fat percentage (right) 2.8 11.2 13.9 3.1 -3.5 -3.5 -3.2 -2.7 -3.7 -3.6
Trunk fat-free mass 0.7 4.2 4.9 2.2 -2.0 -2.2 -2.2 -2.1 -1.7 -1.9
Hip circumference 2.1 9.2 10.2 3.0 -3.1 -3.2 -3.1 -3.0 -3.0 -3.0
Time employed in main current job 0.2 0.3 0.9 -0.7 -0.2 -0.4 0.2 0.4 -1.0 0.3
Alcohol intake versus 10 years previously 0.5 0.8 1.3 -1.0 0.9 1.1 0.9 1.0 0.6 0.6
Father’s age at death 0.2 0.2 1.2 0.2 0.3 0.0 -0.1 -0.2 1.1 0.4
Worrier / anxious feelings 2.4 4.5 5.8 -1.9 2.4 2.2 2.2 1.5 2.4 2.0
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 2.5 1.2 -1.1 -1.4 -1.0 -1.6 -1.5 -1.3
Falls in the last year 0.2 0.3 1.1 0.1 -0.6 -0.3 -0.1 0.2 -1.0 -0.7
Hair/balding pattern: Pattern 3 5.3 7.8 11.0 -3.3 2.6 3.0 3.1 2.9 1.7 2.6
Number of live births 0.1 0.1 0.4 0.2 0.2 0.2 0.1 -0.1 0.7 0.2
Forced expiratory volume in 1-second (FEV1) 2.0 6.8 8.5 -2.1 2.8 2.7 2.7 2.3 2.9 2.7
Pulse rate 3.4 5.7 6.5 2.5 -2.5 -2.5 -2.4 -2.4 -2.1 -2.1
Happiness 0.1 0.1 0.4 0.2 -0.2 -0.3 -0.1 -0.5 -0.6 0.0
Noisy workplace 0.5 0.6 1.0 0.7 -0.8 -0.7 -0.8 -0.6 -1.0 -1.0
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.2 -1.1 1.2 1.3 1.4 1.5 1.0 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.5 0.1 0.5 0.5 0.5 0.4 0.7 0.7
Mouth/teeth dental problems: Dentures 2.2 3.8 5.6 2.4 -2.1 -1.7 -2.1 -2.0 -1.0 -2.0
Asthma 3.1 6.0 7.2 2.3 -2.6 -2.6 -2.7 -2.5 -1.7 -2.5
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 4.2 0.3 -1.7 -1.4 -1.3 -1.2 -1.9 -2.0
Medication: Cholesterol lowering 1.1 1.8 4.1 0.4 -1.4 -1.5 -1.1 -0.9 -2.0 -1.5
Depression (self-reported) 4.1 4.9 5.8 2.0 -2.1 -2.4 -2.4 -2.1 -2.2 -2.2
Medication: Lansoprazole 0.3 0.4 1.1 0.7 -0.2 -0.7 -1.1 -0.7 -0.1 -0.3
Prospective memory result 1.0 1.2 1.9 -0.6 1.3 1.1 1.1 0.7 1.4 1.3
Lung cancer (father) 0.1 0.1 0.2 0.3 -0.4 -0.1 -0.2 -0.3 0.2 -0.4
Illnesses of mother 0.1 0.1 0.2 0.1 -0.4 0.1 -0.2 0.5 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.0 7.3 -2.0 2.7 2.6 2.5 2.3 2.6 2.3
Pulse wave Arterial Stiffness index 1.6 1.9 4.6 0.1 -1.8 -1.1 -0.8 -0.8 -2.2 -1.8
Impedance of arm (left) 0.4 1.6 2.2 1.0 -1.3 -1.4 -1.2 -1.1 -1.5 -1.3
Arm fat mass (right) 2.7 11.2 13.3 3.2 -3.5 -3.5 -3.2 -2.8 -3.6 -3.5
Trunk predicted mass 0.8 4.4 5.2 2.3 -2.1 -2.3 -2.2 -2.1 -1.7 -1.9
Standing height 0.6 5.6 6.9 2.3 -2.3 -2.6 -2.6 -2.5 -2.0 -2.1
Length of working week for main job 0.3 0.3 1.2 -0.0 0.6 0.3 0.0 0.0 1.1 0.8
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.3 0.2 -0.3 -0.6 -0.3 0.4 0.4
Breastfed as a baby 1.4 1.7 2.8 -1.7 1.1 1.4 1.3 1.5 1.0 1.0
Tense / ‘highly strung’ 0.0 0.1 0.3 0.5 0.0 -0.2 0.1 -0.0 -0.5 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.6 4.7 1.9 -1.6 -2.2 -2.0 -1.9 -1.6 -2.0
Hair/balding pattern: Pattern 4 0.4 0.9 1.3 -0.9 1.1 0.9 0.8 0.7 1.1 0.8
Birth weight of first child 4.5 8.1 10.6 -1.9 3.2 3.0 3.0 2.5 3.2 3.0
Peak expiratory flow (PEF) 5.6 12.9 14.7 -3.2 3.7 3.5 3.7 3.5 3.8 3.7
Pulse wave reflection index 2.4 2.9 4.9 -2.2 1.7 1.9 1.9 1.5 1.0 1.5
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.5 0.0 -1.1 -1.3 -1.2 -0.5 -1.9 -1.1
Loud music exposure frequency 0.1 0.1 0.4 -0.2 0.2 0.1 0.1 0.6 0.1 0.6
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.2 -1.1 1.2 1.2 1.5 1.0 1.2 1.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.4 0.7 -0.6 -0.2 -0.6 -1.2 0.3 -0.3
Blood clot in the leg (DVT) 1.1 1.4 4.8 1.1 -0.6 -1.0 -1.5 -2.2 0.3 -0.6
Medication: Paracetamol 2.3 3.8 5.5 2.1 -1.7 -1.9 -2.3 -2.1 -1.1 -2.1
Headache pain in last month 0.3 0.5 0.7 0.5 -0.6 -0.7 -0.6 -0.8 -0.8 -0.9
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 4.0 -0.6 1.3 1.2 0.9 0.6 2.0 1.3
Glaucoma (self-reported) 0.8 0.9 1.3 -1.2 1.1 0.9 0.8 0.9 0.4 1.1
Gout (self-reported) 0.8 1.1 2.5 1.6 -0.8 -0.5 -0.8 -1.3 0.1 -1.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.4 1.0 -0.9 -1.0 -0.8 -1.1 -0.8 -1.2
Medication: Amlodipine 0.4 0.6 1.2 -0.6 0.9 0.9 0.9 0.3 1.1 0.6
Medication: Ventolin 100micrograms inhaler 0.7 0.8 1.5 0.8 -0.6 -1.2 -1.2 -1.0 -0.5 -0.9
Birth weight 1.0 2.1 2.8 -1.0 1.6 1.4 1.5 1.5 1.7 1.3
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.0 1.4 -0.4 -0.9 -0.9 -1.4 -0.2 -0.4
High blood pressure (siblings) 0.5 0.7 1.2 1.1 -0.8 -0.8 -0.5 -1.0 -0.6 -1.1
Forced vital capacity (FVC), Best measure 1.4 5.3 8.3 -1.5 2.6 2.6 2.3 1.8 2.9 2.0
Body fat percentage 2.8 10.9 13.4 3.0 -3.4 -3.5 -3.2 -2.8 -3.7 -3.5
Leg fat percentage (right) 1.9 7.0 8.0 2.6 -2.6 -2.8 -2.6 -2.4 -2.8 -2.6
Arm fat-free mass (right) 0.6 3.2 4.6 2.1 -1.6 -1.9 -1.9 -1.9 -1.2 -1.6
Exposure to tobacco smoke outside home 4.7 6.2 7.8 -2.5 2.8 2.4 2.2 2.1 2.6 2.7
Comparative body size at age 10 1.7 4.7 7.0 2.0 -2.3 -2.3 -1.8 -1.3 -2.6 -2.5
Number of full brothers 0.7 0.9 3.6 0.2 -1.0 -0.8 -0.4 -0.2 -1.9 -0.9
Worry too long after embarrassment 0.4 0.6 1.7 0.0 -0.9 -0.9 -0.6 -0.2 -1.3 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 6.4 8.3 10.2 2.6 -2.9 -3.2 -3.0 -2.6 -3.1 -2.8
Wheeze or whistling in the chest in last year 6.7 11.9 13.7 3.4 -3.7 -3.4 -3.5 -3.5 -3.0 -3.6
Number of children fathered 0.2 0.2 1.6 1.2 -0.0 -0.2 -0.3 -0.1 -0.2 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 0.1 1.1 0.6 0.7 0.3 1.2 0.9
Age at first live birth 0.5 0.9 2.4 -0.9 0.7 0.8 1.1 1.5 0.0 0.7
Pulse wave peak to peak time 1.4 1.6 3.9 -0.1 1.6 1.0 0.8 0.7 2.0 1.6
Health satisfaction 2.8 3.6 4.2 1.9 -1.7 -2.0 -1.9 -2.1 -1.5 -2.0
Shortness of breath walking on level ground 9.0 10.7 14.1 3.0 -3.2 -3.7 -3.8 -3.4 -2.7 -3.1
Qualifications: College or University degree 0.3 0.9 2.6 -1.0 0.1 0.2 0.9 1.6 -1.2 -0.1
Eye problems/disorders: None of the above 0.3 0.4 0.7 -0.6 0.7 0.3 0.5 0.5 0.7 0.9
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.1 1.1 -1.0 -0.6 -0.5 -0.8 -0.8 -0.8
Emphysema/chronic bronchitis 0.1 0.1 0.5 -0.0 -0.0 0.1 0.1 0.5 -0.7 -0.0
Medication for pain relief, constipation, heartburn 1.3 2.2 4.4 -1.1 1.3 1.3 1.3 1.2 1.7 2.1
Neck or shoulder pain in last month 0.1 0.1 0.3 -0.0 0.2 0.2 0.5 0.3 -0.3 -0.1
Medication: Blood pressure 0.2 0.4 1.4 0.3 -0.5 -0.6 -0.4 -0.2 -1.2 -0.3
Angina (self-reported) 0.1 0.2 0.7 -0.3 0.4 0.3 0.5 0.8 -0.1 0.1
Migraine (self-reported) 3.6 4.4 6.5 -2.5 2.1 2.1 2.2 2.3 1.4 2.0
Medication: Ibuprofen 1.0 1.2 2.7 0.4 -1.2 -0.8 -0.8 -0.9 -1.4 -1.6
Medication: Allopurinol 0.8 1.1 2.1 1.0 -1.0 -0.8 -1.0 -1.3 -0.6 -1.5
Medication: Omeprazole 0.7 0.8 1.6 -0.4 0.9 1.3 1.1 0.6 1.2 0.3
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.5 -0.1 0.4 0.3 0.2 -0.4 0.1
Mean time to correctly identify matches 0.4 0.8 1.3 -0.8 1.0 1.1 0.8 0.9 0.9 0.6
Heart disease (mother) 1.4 1.7 2.5 -0.8 1.4 1.3 1.2 1.0 1.6 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 0.6 -0.6 -0.4 -0.5 -0.1 -0.5 -0.2
Whole body fat mass 2.8 11.7 13.8 3.2 -3.6 -3.6 -3.3 -3.0 -3.7 -3.6
Leg fat mass (right) 2.7 10.6 11.8 3.2 -3.3 -3.4 -3.2 -3.0 -3.2 -3.3
Arm predicted mass (right) 0.7 3.8 4.9 2.2 -1.8 -2.1 -2.2 -2.1 -1.4 -1.8
Pulse rate, automated reading 1.5 5.0 6.0 2.0 -2.4 -2.3 -2.1 -2.3 -2.5 -2.1
Alcohol intake frequency. 0.1 0.1 0.6 -0.0 -0.0 -0.4 -0.3 -0.2 -0.8 -0.0
Comparative height size at age 10 1.7 9.2 11.4 3.2 -3.0 -3.3 -3.4 -3.0 -2.7 -2.5
Number of full sisters 0.8 1.0 1.8 -0.9 1.0 0.9 1.0 1.1 0.4 1.3
Suffer from ‘nerves’ 0.1 0.2 0.6 0.8 -0.0 -0.4 -0.5 -0.5 0.1 -0.2
Overall health rating 4.9 10.6 12.9 3.1 -3.2 -3.6 -3.2 -3.6 -2.9 -3.1
Chest pain or discomfort 0.6 0.8 2.0 0.5 -1.0 -0.6 -0.8 -0.5 -1.4 -1.1
Had major operations 0.7 0.8 2.1 1.4 -0.5 -0.8 -0.9 -1.3 -0.3 -0.7
Age at last live birth 0.2 0.3 0.8 -0.4 0.2 0.3 0.8 0.9 -0.5 -0.1
Family relationship satisfaction 2.0 2.5 4.0 1.5 -1.3 -2.0 -1.9 -1.6 -1.5 -1.0
Leg pain on walking 3.8 4.7 6.0 1.7 -2.1 -2.5 -2.2 -2.2 -2.3 -2.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 2.0 1.3 -1.1 -0.7 -0.6 -1.0 -0.8 -1.4
Commuting to job workplace: Car/motor vehicle 1.7 2.0 4.0 -0.4 2.0 1.4 1.1 0.4 1.8 1.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.9 -0.8 -0.9 -0.2 -0.4 -0.5 -0.5 -0.8
Medication: Aspirin 0.3 0.3 1.0 0.7 -0.2 -0.6 -0.3 -0.1 -1.0 -0.6
Supplements: Vitamin C 0.9 1.0 2.0 -0.9 1.3 0.7 1.0 0.9 0.8 1.4
Knee pain experienced in last month 0.6 0.9 1.8 1.0 -0.9 -1.1 -1.0 -0.4 -1.4 -0.7
Hypertension (Self-reported) 0.1 0.2 0.6 0.3 -0.3 -0.0 0.0 -0.4 -0.8 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.0 5.2 -1.8 1.3 2.3 2.2 2.1 1.0 0.9
Illnesses of father: Heart disease 0.1 0.1 0.4 0.6 0.3 -0.3 -0.3 -0.1 0.3 -0.3
Illnesses of siblings: Diabetes 4.1 5.1 8.4 2.2 -2.0 -2.4 -2.6 -2.9 -1.0 -2.2
Smoking status: Previous 0.4 0.7 1.6 -1.1 0.3 0.2 0.8 1.3 -0.9 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 4.3 1.4 -1.2 -2.1 -1.9 -1.4 -1.5 -1.1
Whole body fat-free mass 1.0 5.6 6.6 2.4 -2.3 -2.6 -2.5 -2.4 -2.0 -2.3
Leg fat-free mass (right) 1.2 6.7 7.5 2.5 -2.6 -2.7 -2.7 -2.5 -2.4 -2.6
Arm fat percentage (left) 2.9 11.6 14.2 3.2 -3.6 -3.5 -3.2 -2.8 -3.8 -3.7
Average weekly red wine intake 0.3 0.5 1.2 -0.0 0.8 0.3 0.3 0.8 0.8 1.1
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.6 -1.2 0.4 0.2 0.5 0.9 0.0 0.5
Mood swings 0.1 0.2 0.5 0.6 -0.1 -0.4 -0.3 -0.5 -0.7 -0.4
Loneliness, isolation 0.3 0.4 0.9 0.4 -0.7 -0.5 -0.7 -0.3 -0.9 -0.8
Long-standing illness, disability or infirmity 2.4 3.6 5.3 2.0 -1.6 -2.3 -2.1 -2.1 -1.6 -1.5
Ever had bowel cancer screening 0.7 0.8 1.5 0.3 -1.0 -0.9 -1.2 -0.9 -0.8 -0.8
Diabetes diagnosed by doctor 2.3 3.8 4.8 2.0 -1.9 -1.9 -1.8 -2.1 -1.7 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 4.2 4.5 5.7 2.1 -1.9 -2.4 -1.9 -2.3 -2.3 -1.8
Friendships satisfaction 0.2 0.2 0.6 -0.7 0.3 0.2 0.3 0.8 -0.2 0.6
Qualifications: nursing, teaching 1.5 2.4 3.5 -1.4 1.6 1.7 1.9 1.8 1.1 1.1
Commuting to job workplace: Walk 0.3 0.3 1.0 -0.7 0.1 0.4 0.5 1.0 -0.0 -0.2
Eye problems/disorders: Cataract 1.2 1.3 2.1 1.4 -1.2 -0.8 -1.1 -1.3 -0.5 -1.5
Mouth/teeth dental problems: Mouth ulcers 5.9 9.4 11.4 -2.8 3.3 3.4 3.0 2.5 3.4 3.0
Medication for cholesterol 1.4 2.1 4.3 2.1 -1.2 -1.5 -1.7 -1.7 -0.4 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.1 1.7 -0.6 -0.9 -1.3 -1.8 0.9 -0.6
Back pain experienced in last month 4.6 6.6 8.0 2.8 -2.4 -2.8 -2.8 -2.6 -2.1 -2.4
Mineral and other dietary supplements 0.8 1.1 1.9 -1.0 1.0 1.4 1.1 1.1 0.8 1.0
Breast cancer (self-reported) 0.9 1.1 3.1 -0.7 1.1 0.8 0.6 0.5 1.8 1.2
Asthma (self-reported) 3.4 6.7 8.4 2.6 -2.7 -2.8 -2.9 -2.7 -1.6 -2.6
Osteoporosis (self-reported) 0.4 0.4 0.6 0.8 -0.8 -0.6 -0.8 -0.5 -0.7 -0.6
Osteoarthritis (self-reported) 0.6 0.8 1.5 -0.8 0.7 1.0 1.2 1.2 0.1 0.5
Medication: Aspirin 0.2 0.3 1.1 0.5 -0.2 -0.4 -0.1 0.0 -1.0 -0.6
Medication: Gliclazide 0.9 1.0 1.4 1.2 -0.9 -0.9 -1.0 -0.9 -1.0 -1.0
Illnesses of father: None of the above (group 1) 0.8 0.9 1.4 -0.9 0.9 1.0 0.9 1.0 0.8 1.2
Smoking status: Current 3.8 6.1 9.4 3.1 -2.3 -2.2 -2.3 -2.9 -1.7 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.2 6.9 8.9 -2.2 2.7 2.9 3.0 2.6 2.4 2.5
Whole body water mass 1.0 5.6 6.5 2.5 -2.3 -2.5 -2.5 -2.4 -2.0 -2.3
Leg predicted mass (right) 1.3 6.7 7.6 2.5 -2.6 -2.8 -2.7 -2.5 -2.4 -2.6
Arm fat mass (left) 3.0 12.4 13.8 3.5 -3.7 -3.7 -3.4 -3.0 -3.7 -3.7
Number of self-reported non-cancer illnesses 0.7 1.2 1.9 1.4 -0.8 -1.2 -0.9 -1.4 -0.7 -1.1
Average weekly champagne plus white wine intake 0.1 0.2 0.7 -0.2 -0.1 -0.3 -0.0 0.4 -0.8 -0.4
Miserableness 1.7 2.9 4.2 1.4 -1.6 -1.8 -1.5 -1.7 -2.0 -1.8
Guilty feelings 0.4 0.6 0.8 0.8 -0.6 -0.9 -0.9 -0.6 -0.9 -0.9
Wears glasses or contact lenses 4.3 5.0 7.8 -2.8 1.8 2.4 2.6 2.6 1.4 1.6
Ever taken oral contraceptive pill 4.4 4.9 7.1 1.7 -2.5 -2.4 -2.1 -1.1 -2.7 -2.5
Hearing aid user 0.4 0.4 0.8 0.8 -0.5 -0.6 -0.9 -0.5 -0.4 -0.7
Mother’s age at death 0.4 0.5 1.6 1.2 -0.5 -0.6 -0.8 -0.5 0.1 -0.6
Financial situation satisfaction 1.2 1.5 4.5 1.6 -0.4 -1.2 -1.4 -2.1 0.1 -0.4
Tinnitus: Yes, now most or all of the time 4.4 5.2 8.0 2.4 -2.0 -2.8 -2.6 -2.4 -1.9 -1.6
Commuting to job workplace: Public transport 0.0 0.0 0.1 -0.1 0.1 -0.2 -0.3 0.1 0.3 0.2
Eye problems/disorders: Glaucoma 0.4 0.4 1.1 -1.0 0.6 0.6 0.7 0.6 -0.2 0.6
Medication: Blood pressure 1.0 2.0 2.8 -1.7 1.4 1.5 1.7 1.4 0.8 1.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.2 0.4 -0.7 -0.3 0.1 0.0 -1.5 -0.8
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.5 0.1 0.3 -0.1 0.0 -0.5 0.7 0.4
High cholesterol (Self-reported) 0.1 0.2 0.6 -0.5 -0.0 0.0 0.5 0.0 -0.8 -0.3
Medication: Bendroflumethiazide 0.0 0.0 0.0 0.2 0.0 -0.1 -0.1 -0.1 -0.2 0.0
Medication: Paracetamol 4.4 6.8 9.2 3.0 -2.4 -2.5 -2.9 -2.9 -1.4 -2.8
Medication: Lisinopril 0.4 0.5 1.3 0.6 -0.5 -0.3 -0.3 -0.4 -1.0 -1.1
Medication: Atorvastatin 0.1 0.1 0.6 -0.4 -0.1 -0.3 -0.0 0.1 -0.8 -0.1
Illnesses of father: High blood pressure 0.3 0.4 1.0 -0.6 0.8 0.5 0.6 1.0 0.1 0.6
Alcohol drinker status: Never 0.6 0.7 1.5 -0.9 0.6 1.0 1.2 0.8 -0.0 0.9
Ever smoked 0.2 0.3 0.6 -0.7 0.4 0.6 0.8 0.8 -0.1 0.3
Basal metabolic rate 1.4 7.9 8.9 2.9 -2.8 -3.0 -2.9 -2.8 -2.5 -2.7
Leg fat percentage (left) 1.3 4.8 6.6 2.0 -2.2 -2.3 -2.0 -1.8 -2.6 -2.3
Arm fat-free mass (left) 0.9 4.3 5.2 2.2 -2.0 -2.3 -2.2 -2.0 -1.8 -1.9
Number of operations (self-reported) 0.7 1.0 1.9 1.2 -0.7 -1.1 -1.1 -1.4 -0.3 -0.8
Average weekly beer plus cider intake 1.6 2.3 4.5 2.1 -1.4 -1.2 -1.6 -1.8 -0.2 -1.5
Irritability 0.8 1.4 1.9 1.1 -1.0 -1.3 -1.0 -1.3 -1.4 -1.1
Risk taking 0.2 0.3 0.7 0.2 -0.7 -0.6 -0.6 -0.4 -0.8 -0.6
Ever had prostate specific antigen (PSA) test 2.8 3.3 6.0 2.5 -1.5 -1.8 -1.9 -2.1 -1.0 -1.5
Fractured/broken bones in last 5 years 1.5 1.9 3.9 2.0 -1.2 -1.4 -1.1 -1.2 -0.6 -1.7
Age started oral contraceptive pill 0.3 0.4 1.3 0.3 0.7 0.2 0.3 -0.6 1.1 0.5
Diastolic blood pressure, automated reading 0.6 1.9 2.3 1.4 -1.4 -1.3 -1.3 -1.3 -1.5 -1.4
Ever depressed for a whole week 2.5 3.1 4.3 1.6 -1.7 -2.0 -2.1 -1.9 -1.5 -1.4
Unable to work because of sickness or disability 0.5 0.7 1.6 1.1 -0.5 -0.8 -1.0 -1.3 -0.0 -0.2
Commuting to job workplace: Cycle 0.2 0.2 0.5 -0.3 -0.7 -0.3 0.1 -0.1 -0.6 -0.6
Myopia 1.0 1.4 3.4 -0.7 1.3 0.8 0.7 0.4 1.8 1.8
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.4 -0.0 0.0 -0.1 -0.3 0.1 0.6 0.3
Cholesterol lowering medication 2.3 3.4 4.9 -1.9 2.0 2.1 2.2 1.9 1.2 1.5
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.6 0.4 0.4 0.3 0.3 -0.1 0.8 -0.3
Pain experienced in last month 0.6 1.0 2.4 -0.4 1.0 1.2 0.8 0.5 1.6 1.1
Supplements: Calcium 1.5 1.7 2.1 1.4 -1.2 -1.5 -1.1 -1.4 -1.1 -1.3
Basal cell carcinoma (self-reported) 0.9 1.1 3.6 -0.6 0.9 0.9 0.8 0.4 1.9 1.2
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.3 0.1 -0.6 -0.4 0.0 0.4 -1.2 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.4 1.0 -0.6 -0.9 -1.4 -2.1 0.5 -0.5
Heart disease (siblings) 2.2 2.7 3.8 0.8 -1.9 -1.7 -1.8 -1.3 -1.9 -1.9
Alcohol drinker status: Previous 1.6 1.8 3.3 1.6 -1.1 -1.2 -1.4 -1.8 -0.3 -1.4
Pack years of smoking 2.2 3.3 4.5 1.5 -2.1 -1.7 -1.7 -1.9 -1.7 -1.9
Impedance of whole body 0.0 0.1 0.4 -0.0 -0.3 -0.3 -0.2 -0.1 -0.6 -0.3
Leg fat mass (left) 2.3 9.0 9.9 2.9 -3.1 -3.1 -2.9 -2.8 -3.0 -3.1
Arm predicted mass (left) 0.9 4.5 5.5 2.3 -2.0 -2.4 -2.3 -2.0 -2.0 -1.9