Hub : Genes

JUP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.238	0.0540	1.5e-06	0.137	0.079	0.119	0.127	0.129	2.3e-16	8.0e-10	2.7e-14	3.8e-15	1.8e-15
2	GTEx	Artery Aorta	0.160	0.0580	1.2e-03	0.118	NA	0.059	NA	0.108	4.8e-07	NA	3.5e-04	NA	1.6e-06
3	GTEx	Whole Blood	0.570	0.0410	0.0e+00	0.507	NA	0.509	NA	0.514	1.2e-53	NA	6.3e-54	NA	1.2e-54
4	NTR	Blood	0.149	0.0301	0.0e+00	0.114	0.083	0.112	0.113	0.114	8.0e-35	1.6e-25	2.7e-34	2.4e-34	1.2e-34
5	YFS	Blood	0.635	0.0305	0.0e+00	0.439	0.494	0.509	0.501	0.504	1.2e-160	4.4e-189	4.6e-197	9.6e-193	1.5e-194

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.1	1.7	3.5	-1.9	0.7	-1.3	-1.3	-1.1
Bipolar Disorder or Schizophrenia	0.6	1.4	2.1	-1.1	1.4	-1.3	-1.2	-0.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.2	0.7	0.1	1.1	1.1	0.7
Depression (Nagel 2018)	1.1	1.7	4.1	1.4	2.0	-0.6	-0.7	-1.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.6	0.5	0.3	-0.7	-0.7	-0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.9	0.4	0.6	0.5	0.2
Schizophrenia (2018)	0.2	0.4	1.6	0.1	1.3	-0.6	-0.5	0.1
Schizophrenia vs Biploar Disorder	1.3	1.7	2.5	1.6	-1.1	1.5	1.5	0.9
Worry (Nagel 2018)	0.2	0.4	0.6	0.6	-0.5	0.8	0.7	0.6
Alzheimer’s Disease (in mother)	1.5	1.7	2.7	-0.2	1.0	-1.6	-1.6	-1.5
Alzheimer’s Disease (in father)	0.6	0.6	1.9	-1.4	0.9	-0.4	-0.4	0.1
Alzheimer’s Disease (including proxy)	1.0	1.5	2.1	-0.5	1.5	-1.4	-1.4	-1.0
Crohns Disease (2017)	0.2	0.5	1.4	1.2	-0.4	-0.7	-0.7	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.5	-0.4	-0.6	-0.6	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.8	-0.3	0.2	-0.0	0.0	0.9
Major Depression (MDD)	0.4	0.5	2.2	-0.1	1.5	-0.0	0.1	0.7
Reaction Time	0.3	0.5	0.8	0.9	-0.9	0.8	0.7	0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.2	0.1	1.5	-1.0	-0.8	-1.1
Breast Cancer	0.7	1.7	4.4	-2.1	1.7	-0.4	-0.3	1.0
Ovarian Cancer	1.8	2.4	4.2	-2.0	1.8	-1.4	-1.3	-1.0
Prostate Cancer	0.5	0.7	1.0	-0.7	-0.8	0.8	0.8	1.0
Age at First Birth	0.5	0.7	1.1	0.0	-0.9	0.9	1.1	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	-0.2	-0.1	0.2
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	1.3	-1.0	0.7	0.8	0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.0	0.4	-0.1	0.1	0.3
Crohns Disease (2012)	0.6	1.0	4.1	2.0	-0.7	0.1	0.1	0.3
Mean Putamen Volume	1.7	2.0	8.9	-3.0	0.1	-0.7	-0.6	-0.5
Fasting Glucose	1.4	1.7	3.5	-0.2	1.9	-1.4	-1.3	-1.0
HbA1C	0.5	0.6	1.1	-0.6	0.3	-1.1	-0.9	-0.6
HDL Cholesterol	0.6	1.1	4.6	-2.2	0.6	0.1	0.3	0.4
LDL Cholesterol	0.3	0.5	1.4	-0.4	-1.2	0.7	0.8	-0.0
Lupus	0.7	1.0	1.5	1.2	-0.4	1.1	1.1	1.0
Neuroticism (2016)	0.4	0.5	0.8	0.9	0.4	0.8	0.9	0.5
Primary Biliary Cirrhosis	0.2	0.3	1.2	0.4	-0.0	-0.3	-0.3	-1.1
Rheumatoid Arthritis	0.5	0.7	1.0	0.7	-0.2	1.0	1.0	1.0
Schizophrenia (2014)	0.0	0.1	0.2	-0.2	0.5	-0.1	0.1	0.3
Triglycerides	0.4	0.7	1.8	1.3	-0.7	-0.6	-0.6	-0.6
Type 2 Diabetes (T2D) (2012)	1.1	1.2	1.7	1.1	-1.1	1.0	1.3	0.9
Ulcerative Colitis	0.6	0.9	2.1	-0.4	-0.6	1.0	1.0	1.4
Blood Eosinophil Count	0.0	0.2	0.5	0.7	-0.5	-0.2	-0.3	-0.3
Blood Platelet Count	0.7	7.6	11.9	-0.7	1.8	-3.4	-3.3	-3.5
Blood Red Count	0.4	3.9	5.7	-2.1	1.6	-2.4	-2.3	-1.4
Blood White Count	1.2	9.1	10.7	3.2	-2.6	3.3	3.2	2.7
Heel T-Score	2.9	23.1	46.4	4.5	-6.8	4.2	4.4	3.4
BMI	0.3	1.8	3.0	0.9	-1.0	1.6	1.7	1.1
Height	0.2	4.3	7.2	1.1	1.0	-2.5	-2.4	-2.7
Waist Hip Ratio (WHR)	0.6	2.6	8.2	2.9	-0.9	1.4	1.5	0.1
Systolic Blood Pressure	2.3	11.6	25.6	0.2	5.1	-3.6	-3.5	-2.7
Smoking Status	0.5	1.1	3.2	1.5	1.8	-0.1	-0.0	0.0
Allergy or Eczema	0.3	0.8	1.6	-1.2	-1.3	-0.4	-0.5	-0.6
Cardiovascular Disease	0.2	0.5	1.1	-0.5	1.0	-0.6	-0.6	-0.8
Hypothyroidism (self reported)	1.7	3.9	6.7	2.2	0.2	-1.9	-2.0	-2.6
Respiratory disease	0.3	0.7	1.1	-0.2	-0.6	1.1	1.0	0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.0	-0.3	-1.7	0.7	0.6	0.1
Lung FEV1/FVC ratio	0.9	4.6	8.4	0.7	-2.9	2.2	2.3	1.9
Lung FVC	0.4	2.0	3.0	1.7	0.5	-1.4	-1.6	-1.5
Neuroticism	1.2	3.0	4.8	0.5	-1.5	2.2	2.2	1.7
Chronotype (morning person)	0.1	0.1	0.4	-0.3	-0.3	0.4	0.3	0.6
Hair Pigment	0.0	0.9	1.4	-1.2	0.8	1.0	0.8	0.8
Tanning	0.2	2.3	6.5	1.1	2.6	-1.1	-1.3	-0.9
Hand grip strength (left)	0.3	0.9	2.9	1.7	0.9	-0.5	-0.6	-0.4
Number of treatments/medications taken	0.6	1.0	2.2	0.4	0.3	-1.1	-1.2	-1.5
Average weekly spirits intake	0.1	0.1	0.3	-0.5	0.2	-0.1	-0.1	0.5
Sensitivity / hurt feelings	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	0.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.7	1.6	0.3	-0.8	-0.9	-1.1
Hearing difficulty/problems: Yes	0.2	0.4	0.8	-0.1	0.4	0.8	0.9	0.5
Relative age of first facial hair	0.3	0.6	0.9	0.4	-0.8	0.8	0.9	0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	0.7	-1.2	-0.9	-0.9	-1.1
Ever used hormone-replacement therapy (HRT)	1.9	2.4	5.2	-1.4	0.4	1.6	1.5	2.3
Ever had hysterectomy (womb removed)	1.0	1.1	3.1	1.1	1.8	-0.7	-0.7	-0.2
Systolic blood pressure, automated reading	0.7	2.0	5.9	0.9	2.4	-1.2	-1.2	-0.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.4	-1.8	-0.8	1.0	1.0	0.9
Angina	0.7	0.9	3.4	-1.8	0.9	0.3	0.3	0.3
Medication for hormone replacement therapy	1.0	1.1	1.9	0.7	-0.5	1.3	1.2	1.4
Vitamin and mineral supplements	0.2	0.3	1.6	0.2	-1.2	0.1	0.1	0.2
Supplements: Zinc	0.2	0.2	0.5	0.0	0.7	0.3	0.3	0.7
Medication: Co-codamol	0.2	0.2	0.7	0.3	0.8	-0.4	-0.5	-0.1
Medication: Metformin	0.5	0.6	1.4	1.2	-1.0	-0.3	-0.3	-0.8
Diabetes (father)	0.5	0.6	1.6	1.3	0.7	-0.5	-0.5	-0.7
Diabetes (mother)	1.4	1.8	7.7	0.4	-2.8	0.7	0.7	0.5
Severe depression (siblings)	0.8	0.8	2.3	-1.5	-0.4	0.6	0.5	1.1
Pack years adult smoking proportion	1.0	1.5	2.6	-0.1	-0.8	1.6	1.6	1.4
Impedance of leg (right)	2.5	12.1	17.4	-3.0	3.0	-4.2	-4.1	-2.9
Leg fat-free mass (left)	0.2	1.2	4.9	2.2	-0.6	0.7	0.7	-0.1
Trunk fat percentage	0.4	1.8	2.6	-1.5	0.1	-1.6	-1.4	-1.4
Hand grip strength (right)	0.8	2.3	3.8	1.3	2.0	-1.5	-1.6	-1.1
Townsend deprivation index at recruitment	0.4	0.6	2.2	0.9	1.5	-0.1	-0.0	0.2
Current tobacco smoking	0.4	0.7	3.4	0.2	1.8	-0.1	-0.1	0.0
Average weekly fortified wine intake	2.4	2.8	4.9	-0.5	0.1	-2.1	-2.2	-2.1
Maternal smoking around birth	0.3	0.5	1.0	1.0	-0.4	0.6	0.6	0.7
Fed-up feelings	2.6	4.6	6.8	0.9	-1.9	2.6	2.6	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.0	1.7	0.3	0.5	0.5	0.1
Relative age voice broke	0.4	0.6	1.4	-0.3	-0.5	0.7	0.8	1.2
Taking other prescription medications	0.1	0.2	0.8	0.9	0.3	-0.2	-0.1	-0.5
Age when periods started (menarche)	0.6	1.4	6.1	-0.4	-2.5	0.5	0.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	-0.4	-1.1	0.5	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	5.2	11.9	14.3	3.1	-3.8	3.6	3.7	3.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	-0.2	-0.0	0.0	0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.0	-0.5	0.2	0.3	0.2
Serious illness, injury or assault to yourself	0.9	1.1	2.7	-0.4	-1.6	1.0	1.0	0.7
High blood pressure	0.2	0.4	0.7	-0.1	0.7	-0.8	-0.6	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.6	0.2	-1.3	0.5	0.3	0.2
Multivitamins +/- minerals	0.3	0.4	0.6	-0.2	0.8	0.6	0.6	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.3
Supplements: Glucosamine	0.7	1.0	1.2	-0.8	1.1	1.0	1.0	1.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.6	-1.1	2.1	0.5	0.5	0.8
Medication: Atenolol	0.2	0.3	0.7	-0.9	0.1	-0.4	-0.4	-0.6
Medication: Levothyroxine sodium	0.8	1.3	4.2	2.0	-0.8	-0.5	-0.5	-1.2
Sitting height	0.8	5.8	8.8	1.5	1.3	-3.0	-2.9	-2.8
Chronic bronchitis/emphysema (father)	1.1	1.3	1.8	-1.2	0.2	-1.2	-1.2	-1.4
High blood pressure (mother)	0.1	0.1	0.3	-0.5	0.1	-0.3	-0.4	-0.4
Body mass index (BMI)	0.2	0.8	1.4	-0.1	-0.9	1.1	1.2	0.8
Impedance of leg (left)	2.2	10.6	15.7	-3.1	2.4	-4.0	-3.9	-2.7
Leg predicted mass (left)	0.2	1.3	5.1	2.2	-0.7	0.6	0.7	-0.1
Trunk fat mass	0.2	0.7	1.2	-0.8	-0.1	-1.1	-0.9	-1.0
Waist circumference	0.1	0.3	1.1	1.0	-0.4	0.4	0.6	-0.1
Number of incorrect matches in round	0.8	1.3	3.5	-1.2	1.9	-0.8	-0.9	-0.4
Past tobacco smoking	1.0	1.9	4.0	-2.0	-1.5	1.0	0.9	1.1
Alcohol usually taken with meals	1.2	2.0	3.6	0.6	-0.2	-1.6	-1.7	-1.9
Nervous feelings	2.0	3.7	5.7	1.1	-1.3	2.2	2.2	2.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.4	1.1	0.7	1.1	1.1	1.2
Hearing difficulty/problems with background noise	0.0	0.1	0.3	0.0	0.6	0.0	-0.0	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.7	-1.3	0.3	-0.6	-0.6	0.3
Had menopause	0.5	0.6	2.1	-1.5	-0.6	0.2	0.2	0.5
Had other major operations	0.6	0.7	2.1	1.5	-0.3	0.6	0.7	0.7
Forced vital capacity (FVC)	1.7	6.4	10.5	3.2	2.0	-2.3	-2.5	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	5.0	11.4	18.0	4.2	-4.2	2.8	2.9	2.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.3	-0.6	0.1	-0.0	0.3
Qualifications: None of the above	0.1	0.1	0.3	-0.2	0.6	-0.1	-0.1	0.4
Financial difficulties in last 2 years	0.2	0.3	0.8	0.9	0.5	0.0	-0.0	0.6
Mouth/teeth dental problems	0.4	0.5	2.5	0.4	-1.6	-0.1	-0.1	-0.2
Heart attack	0.3	0.3	0.7	-0.3	-0.2	0.8	0.9	0.4
Allergy	0.1	0.3	0.8	0.4	0.9	-0.4	-0.3	-0.2
Pain all over the body in last month	0.3	0.3	0.7	-0.2	0.4	-0.7	-0.8	-0.6
Diabetes (self-reported)	0.5	0.8	3.1	-0.4	-1.8	0.5	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.9	0.6	-1.4	-0.3	-0.3	-0.2
Medication: Ramipril	0.2	0.2	0.6	-0.6	-0.8	0.3	0.4	-0.1
Medication: Simvastatin	0.5	0.8	3.8	-2.0	-0.1	0.3	0.2	-0.0
Fluid intelligence score	0.4	0.8	2.7	1.6	0.3	-0.3	-0.3	-1.0
Illnesses of siblings	1.2	1.7	2.3	1.5	-1.0	1.5	1.5	0.9
Neuroticism score	1.9	4.0	6.3	0.5	-1.3	2.5	2.5	2.4
Weight	0.0	0.2	0.6	0.8	-0.4	-0.0	0.1	-0.3
Impedance of arm (right)	1.2	5.4	8.1	-2.2	1.4	-2.8	-2.8	-2.0
Arm fat percentage (right)	0.1	0.2	1.0	-1.0	-0.1	-0.0	0.1	0.0
Trunk fat-free mass	0.3	1.6	5.9	2.4	-0.5	0.9	1.0	0.4
Hip circumference	0.1	0.4	0.7	-0.7	0.2	-0.9	-0.8	-0.6
Time employed in main current job	1.9	2.2	6.1	-2.5	0.4	1.1	1.1	1.5
Alcohol intake versus 10 years previously	0.6	1.0	2.1	1.0	-1.5	0.9	0.9	0.3
Father’s age at death	1.2	1.6	2.9	1.4	-1.7	0.9	0.8	1.2
Worrier / anxious feelings	0.1	0.1	0.3	0.4	0.0	0.5	0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.7	2.2	-0.1	0.8	0.8	0.6
Falls in the last year	0.2	0.3	1.1	0.3	1.1	-0.3	-0.3	-0.3
Hair/balding pattern: Pattern 3	0.4	0.5	0.9	0.9	0.4	0.9	0.9	0.2
Number of live births	0.1	0.1	0.3	0.1	0.0	-0.6	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	10.2	3.2	0.7	-1.2	-1.4	-1.2
Pulse rate	0.4	0.6	2.3	-1.5	-0.0	-0.5	-0.6	-0.3
Happiness	0.5	0.6	1.1	0.1	1.1	0.7	0.7	0.9
Noisy workplace	0.5	0.6	1.7	-0.2	1.3	0.6	0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.0	0.9	0.7	-1.3	-1.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.0	-0.7	-0.2	-1.4	-1.4	-1.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	0.0	1.3	0.4	0.5	0.5
Asthma	0.1	0.1	0.5	-0.4	0.7	-0.1	-0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	4.5	2.1	-0.5	1.7	1.6	1.7
Medication: Cholesterol lowering	0.3	0.5	2.1	-1.4	0.5	-0.0	-0.0	-0.5
Depression (self-reported)	0.2	0.3	0.8	-0.6	-0.9	0.4	0.4	0.2
Medication: Lansoprazole	2.6	2.9	5.0	-2.2	1.9	-1.7	-1.7	-0.9
Prospective memory result	0.5	0.6	1.6	-1.3	0.8	-0.5	-0.6	-0.2
Lung cancer (father)	1.5	1.8	2.8	-0.1	-1.2	1.7	1.6	1.5
Illnesses of mother	1.3	1.7	3.1	0.4	-0.2	1.8	1.8	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.7	1.9	1.5	-1.1	-1.3	-1.1
Pulse wave Arterial Stiffness index	0.4	0.4	0.6	-0.7	-0.4	0.7	0.8	0.6
Impedance of arm (left)	1.8	8.5	13.5	-2.2	1.7	-3.6	-3.7	-2.9
Arm fat mass (right)	0.0	0.1	0.2	-0.4	-0.4	0.3	0.4	0.3
Trunk predicted mass	0.3	1.7	5.9	2.4	-0.6	1.0	1.1	0.4
Standing height	0.4	4.1	5.3	1.9	1.0	-2.3	-2.2	-2.3
Length of working week for main job	1.2	1.3	5.2	-0.3	2.3	-0.7	-0.6	-0.5
Exposure to tobacco smoke at home	0.6	0.7	1.4	-0.5	0.3	-1.2	-1.1	-0.6
Breastfed as a baby	0.2	0.2	0.7	-0.9	0.3	-0.2	-0.2	-0.5
Tense / ‘highly strung’	1.5	2.4	4.2	0.4	-0.4	2.0	2.0	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.9	-1.0	0.2	1.0	1.0	1.4
Hair/balding pattern: Pattern 4	1.7	4.2	9.4	2.2	-0.4	-1.8	-1.7	-3.1
Birth weight of first child	0.2	0.4	1.7	-1.3	0.6	0.2	0.3	0.1
Peak expiratory flow (PEF)	0.7	1.7	7.3	2.7	-1.2	0.1	-0.0	0.0
Pulse wave reflection index	0.8	1.0	1.4	-1.0	-0.9	1.1	1.2	0.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.7	1.3	-0.1	-1.2	-1.3	-0.9
Loud music exposure frequency	0.0	0.0	0.1	0.0	-0.3	-0.1	-0.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.4	-0.4	-0.3	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.0	0.8	0.7	-1.3	-1.3	-1.4
Blood clot in the leg (DVT)	0.3	0.3	0.5	-0.4	0.5	-0.6	-0.7	-0.6
Medication: Paracetamol	0.3	0.5	1.6	0.9	-1.3	-0.0	-0.1	0.2
Headache pain in last month	0.2	0.3	0.8	0.9	-0.8	-0.0	0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.7	1.3	-1.2	1.2	1.1	1.6
Glaucoma (self-reported)	0.7	0.8	2.5	1.6	-1.0	-0.2	-0.1	-0.7
Gout (self-reported)	0.8	1.0	1.8	0.3	-1.3	1.2	1.2	0.8
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.1	1.5	-0.3	-1.6	-1.6	-2.3
Medication: Amlodipine	0.8	1.1	4.9	-2.2	0.4	-0.5	-0.4	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.4	0.3	-0.7	-0.8	-0.7
Birth weight	0.2	0.5	1.3	-1.2	-0.4	0.5	0.5	0.6
Chronic bronchitis/emphysema (mother)	1.0	1.1	4.7	2.2	0.2	-0.6	-0.5	-0.6
High blood pressure (siblings)	2.2	3.2	8.1	-1.3	2.9	-1.6	-1.6	-1.0
Forced vital capacity (FVC), Best measure	1.3	4.7	5.3	2.2	2.3	-2.0	-2.2	-2.1
Body fat percentage	0.3	1.2	2.8	-1.7	0.1	-1.2	-1.0	-0.9
Leg fat percentage (right)	0.3	1.1	3.5	-1.9	0.4	-1.0	-0.8	-0.7
Arm fat-free mass (right)	0.2	0.9	3.9	2.0	-0.3	0.4	0.5	-0.1
Exposure to tobacco smoke outside home	0.0	0.0	0.2	0.4	-0.0	0.1	0.1	0.2
Comparative body size at age 10	0.4	1.1	2.3	-1.5	-0.3	1.0	0.9	1.2
Number of full brothers	0.1	0.1	0.1	-0.4	0.4	-0.1	-0.2	-0.1
Worry too long after embarrassment	0.2	0.4	1.7	1.3	0.2	0.3	0.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.7	0.6	-0.3	1.9	1.9	1.7
Wheeze or whistling in the chest in last year	0.5	0.9	1.6	-0.8	0.5	-1.2	-1.2	-0.8
Number of children fathered	0.6	0.7	2.3	-0.0	-1.5	0.7	0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	0.2	0.7	1.1	1.1	0.6
Age at first live birth	1.3	2.4	6.4	1.9	-2.5	0.8	0.9	0.4
Pulse wave peak to peak time	0.5	0.6	0.9	0.8	0.6	-0.9	-0.9	-0.7
Health satisfaction	0.4	0.6	0.9	0.0	0.3	-1.0	-0.9	-0.9
Shortness of breath walking on level ground	0.6	0.7	1.4	0.4	-0.3	-1.2	-1.1	-0.7
Qualifications: College or University degree	0.6	1.9	3.0	-0.3	1.7	-1.5	-1.5	-1.4
Eye problems/disorders: None of the above	3.2	3.7	7.3	0.4	-0.8	2.3	2.2	2.7
Mouth/teeth dental problems: Loose teeth	3.3	3.9	6.2	1.6	-0.7	2.4	2.5	2.1
Emphysema/chronic bronchitis	0.7	0.8	3.1	-0.9	-1.8	0.3	0.3	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.7	0.2	-0.5	-0.4	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.6	0.6	-1.3	0.0	0.2	-0.1
Medication: Blood pressure	1.0	1.8	3.6	-0.7	0.9	-1.4	-1.3	-1.9
Angina (self-reported)	0.8	1.1	4.4	-2.1	0.9	0.4	0.4	0.3
Migraine (self-reported)	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.3	-0.3
Medication: Ibuprofen	3.7	4.4	7.1	2.7	-0.8	2.3	2.2	2.1
Medication: Allopurinol	0.2	0.3	0.6	0.1	-0.8	-0.3	-0.3	-0.8
Medication: Omeprazole	0.3	0.4	1.9	0.2	1.4	-0.0	-0.1	-0.1
Medication: Seretide 50 evohaler	0.4	0.4	1.6	0.4	-1.3	0.4	0.3	0.5
Mean time to correctly identify matches	0.2	0.3	1.2	0.3	-1.1	0.3	0.2	-0.1
Heart disease (mother)	0.4	0.5	1.5	-1.2	-0.9	-0.2	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	-0.8	0.2	-0.2	-0.2	-0.1
Whole body fat mass	0.1	0.5	0.8	-0.8	-0.2	-0.9	-0.7	-0.8
Leg fat mass (right)	0.1	0.2	0.4	-0.6	-0.0	-0.6	-0.4	-0.5
Arm predicted mass (right)	0.3	1.5	6.6	2.6	-0.6	0.5	0.6	-0.0
Pulse rate, automated reading	0.6	1.8	6.7	-2.6	0.2	-0.8	-0.9	-0.9
Alcohol intake frequency.	1.1	2.6	7.1	0.8	-2.7	1.4	1.5	1.0
Comparative height size at age 10	0.3	1.4	2.9	-0.2	-0.1	-1.7	-1.6	-1.3
Number of full sisters	0.3	0.4	0.8	0.1	0.8	0.6	0.6	0.9
Suffer from ‘nerves’	1.3	2.0	3.5	0.3	-0.2	1.9	1.9	1.7
Overall health rating	0.1	0.1	0.5	-0.1	0.7	-0.2	-0.1	-0.5
Chest pain or discomfort	0.6	0.9	1.5	0.5	0.4	1.1	1.2	1.2
Had major operations	0.4	0.5	2.2	-0.0	1.5	-0.1	-0.2	-0.4
Age at last live birth	3.4	4.9	14.3	2.1	-3.8	1.6	1.6	1.0
Family relationship satisfaction	0.3	0.3	1.3	1.1	-0.6	0.2	0.1	0.1
Leg pain on walking	0.5	0.6	1.7	-0.7	-1.3	0.4	0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.8	0.3	-0.6	-0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	-0.6	0.9	-0.8	-0.8	-1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	0.9	0.4	-0.4	-0.5	-0.5
Medication: Aspirin	0.3	0.4	1.3	-1.1	0.2	-0.6	-0.5	-0.5
Supplements: Vitamin C	0.2	0.2	0.4	-0.1	0.2	-0.5	-0.5	-0.6
Knee pain experienced in last month	1.0	1.6	2.4	0.1	-1.0	1.6	1.5	1.5
Hypertension (Self-reported)	0.2	0.6	1.1	-0.5	0.2	-1.0	-0.9	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.2	-0.3	-0.1	0.2	0.0	0.4
Illnesses of father: Heart disease	0.2	0.2	0.9	-0.9	-0.6	-0.0	0.1	-0.1
Illnesses of siblings: Diabetes	0.7	0.9	1.1	-1.0	0.9	-1.0	-1.0	-0.6
Smoking status: Previous	0.5	0.8	3.3	1.8	0.5	-0.3	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.0	0.9	2.0	-1.2	-1.2	-1.1
Whole body fat-free mass	0.3	1.5	5.5	2.4	-0.6	0.9	0.9	0.2
Leg fat-free mass (right)	0.3	1.6	5.4	2.3	-1.0	0.9	1.0	0.1
Arm fat percentage (left)	0.1	0.3	1.0	-1.0	-0.1	-0.5	-0.4	-0.4
Average weekly red wine intake	0.2	0.4	1.1	0.8	-1.0	-0.1	-0.2	0.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.4	0.7	-0.8	1.2	1.1	1.1
Mood swings	2.5	4.6	7.4	0.4	-1.0	2.7	2.7	2.7
Loneliness, isolation	0.8	1.1	1.7	-0.3	1.3	-1.3	-1.3	-0.6
Long-standing illness, disability or infirmity	1.5	2.3	4.7	1.0	0.4	-1.7	-1.6	-2.2
Ever had bowel cancer screening	0.1	0.2	0.7	0.1	-0.9	-0.2	-0.1	-0.1
Diabetes diagnosed by doctor	0.6	1.0	4.2	-0.7	-2.0	0.4	0.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.9	1.1	-1.7	0.7	0.8	0.4
Friendships satisfaction	0.4	0.5	2.1	-0.4	1.5	-0.1	-0.1	0.4
Qualifications: nursing, teaching	0.8	1.3	2.3	-1.5	1.4	0.7	0.8	0.9
Commuting to job workplace: Walk	0.5	0.5	2.4	1.6	0.1	0.0	0.1	-0.1
Eye problems/disorders: Cataract	3.6	4.1	7.0	0.4	1.0	-2.6	-2.6	-2.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.2	-1.5	0.8	-0.3	-0.3	0.2
Medication for cholesterol	0.1	0.1	0.2	-0.4	0.5	0.3	0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.4	-0.6	0.0	1.4	1.3	1.6
Back pain experienced in last month	0.7	1.0	1.8	0.4	0.1	-1.3	-1.3	-1.0
Mineral and other dietary supplements	0.6	0.8	1.3	-0.7	-0.3	-1.1	-1.1	-1.0
Breast cancer (self-reported)	0.9	1.1	1.7	0.4	1.1	-1.2	-1.3	-1.0
Asthma (self-reported)	0.0	0.1	0.2	-0.5	0.4	-0.1	-0.1	-0.1
Osteoporosis (self-reported)	0.5	0.6	1.0	-0.7	1.0	-0.9	-0.9	-0.2
Osteoarthritis (self-reported)	3.4	4.5	6.1	1.1	-1.9	2.5	2.4	2.4
Medication: Aspirin	0.5	0.6	1.7	-1.3	0.8	-0.5	-0.4	-0.5
Medication: Gliclazide	0.2	0.2	0.4	0.2	-0.7	0.4	0.4	0.4
Illnesses of father: None of the above (group 1)	0.8	0.9	1.4	1.2	-1.2	0.9	0.7	0.8
Smoking status: Current	0.4	0.7	3.1	0.0	1.7	-0.4	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.3	1.5	-1.5	1.0	0.9	1.0
Whole body water mass	0.3	1.6	5.9	2.4	-0.8	0.9	0.9	0.2
Leg predicted mass (right)	0.3	1.6	5.0	2.2	-1.0	0.9	1.0	0.2
Arm fat mass (left)	0.0	0.0	0.1	-0.0	-0.4	-0.1	-0.0	-0.2
Number of self-reported non-cancer illnesses	1.2	2.0	4.2	0.8	-0.6	-1.6	-1.6	-2.1
Average weekly champagne plus white wine intake	3.1	4.3	7.1	-0.3	0.9	-2.6	-2.7	-2.5
Miserableness	1.6	2.8	4.6	0.9	-0.8	2.1	2.1	1.9
Guilty feelings	0.4	0.5	1.0	0.6	0.5	0.8	0.7	1.0
Wears glasses or contact lenses	0.3	0.4	1.2	-1.1	-0.1	-0.4	-0.4	-0.5
Ever taken oral contraceptive pill	0.5	0.5	1.0	1.0	0.2	0.7	0.7	0.8
Hearing aid user	0.7	0.8	1.3	0.2	-1.0	1.2	1.1	0.8
Mother’s age at death	0.1	0.2	0.7	-0.8	-0.1	-0.1	-0.1	0.1
Financial situation satisfaction	0.7	0.9	1.3	0.8	-0.2	1.1	1.1	1.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	0.5	-0.2	-0.1	-0.2
Commuting to job workplace: Public transport	0.5	0.6	0.9	0.9	-0.9	0.6	0.7	0.6
Eye problems/disorders: Glaucoma	0.7	0.8	2.9	1.7	-0.9	-0.1	0.0	-0.6
Medication: Blood pressure	0.8	1.4	2.6	1.6	-0.2	-1.3	-1.2	-1.2
Pain type(s) experienced in last month: Hip pain	2.1	2.7	4.4	-0.2	-1.3	1.9	1.9	2.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.2	0.8	-0.6	1.5	1.5	1.2
High cholesterol (Self-reported)	0.5	0.9	2.4	-1.5	-1.5	-0.1	-0.1	-0.3
Medication: Bendroflumethiazide	0.8	1.3	2.3	-0.6	0.2	-1.5	-1.5	-1.2
Medication: Paracetamol	0.3	0.5	1.0	1.0	-1.0	-0.4	-0.4	-0.3
Medication: Lisinopril	0.4	0.5	1.1	0.8	-1.1	-0.6	-0.4	-0.6
Medication: Atorvastatin	2.0	2.5	3.8	-1.1	1.2	-1.8	-1.7	-2.0
Illnesses of father: High blood pressure	0.8	1.0	2.7	1.0	1.6	-0.7	-0.6	-0.6
Alcohol drinker status: Never	0.3	0.3	1.6	-0.2	-1.3	-0.1	-0.1	-0.2
Ever smoked	1.7	3.0	6.8	2.6	2.1	-1.2	-1.1	-1.1
Basal metabolic rate	0.2	1.1	4.3	2.1	-0.6	0.5	0.6	-0.0
Leg fat percentage (left)	0.3	0.9	3.4	-1.8	0.1	-0.8	-0.6	-0.4
Arm fat-free mass (left)	0.3	1.3	4.6	2.1	-0.8	0.7	0.8	0.3
Number of operations (self-reported)	0.3	0.4	1.3	1.1	0.8	-0.0	0.0	0.4
Average weekly beer plus cider intake	0.2	0.3	0.9	1.0	-0.0	0.5	0.6	0.0
Irritability	0.1	0.3	0.5	0.1	-0.6	0.6	0.7	0.1
Risk taking	0.6	0.9	2.3	-1.4	1.5	-0.1	-0.1	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.7	0.1	-0.8	0.2	0.1	0.1
Fractured/broken bones in last 5 years	6.4	8.3	11.7	-3.4	2.7	-2.9	-3.0	-2.2
Age started oral contraceptive pill	0.8	1.0	2.5	-0.7	-1.6	0.7	0.7	1.1
Diastolic blood pressure, automated reading	1.0	3.2	10.1	-1.4	3.2	-1.3	-1.2	-1.0
Ever depressed for a whole week	0.3	0.3	1.4	0.1	-1.2	-0.3	-0.3	0.1
Unable to work because of sickness or disability	0.4	0.5	1.0	0.6	-0.3	1.0	0.9	0.5
Commuting to job workplace: Cycle	0.9	1.1	3.6	-1.0	1.9	-0.5	-0.6	-0.5
Myopia	0.9	1.4	5.1	2.3	-0.3	0.8	0.8	0.6
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.1	-0.5	0.1	-0.0	0.4
Cholesterol lowering medication	0.2	0.3	1.0	-0.6	-1.0	-0.1	-0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.6	1.0	-0.6	-0.6	-0.6
Pain experienced in last month	0.5	0.9	1.5	-1.0	1.2	0.9	0.8	0.8
Supplements: Calcium	0.1	0.1	0.7	-0.1	0.8	0.0	0.1	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	-1.4	-0.4	-0.2	-0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.4	0.2	0.5	0.6	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	0.8	-0.9	0.7	-0.8	-0.9	-0.9
Heart disease (siblings)	0.6	0.7	1.2	-1.1	0.6	-0.8	-0.8	-1.0
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.1	-0.4	-0.3	-0.3	-0.6
Pack years of smoking	1.2	1.8	2.8	-0.3	-1.2	1.7	1.6	1.4
Impedance of whole body	2.3	11.6	17.3	-3.0	2.4	-4.2	-4.1	-3.0
Leg fat mass (left)	0.0	0.2	0.4	-0.7	-0.2	-0.5	-0.3	-0.4
Arm predicted mass (left)	0.2	1.1	4.0	2.0	-0.7	0.5	0.6	0.0