Hub : Genes

KCNE4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1230	0.0330	4.4e-07	0.044	0.067	0.057	0.062	0.053	3.6e-06	1.5e-08	1.7e-07	5.3e-08	4.3e-07
2	GTEx	Muscle Skeletal	0.0580	0.0247	8.0e-03	0.008	NA	-0.001	NA	0.001	5.1e-02	NA	3.8e-01	NA	2.4e-01
3	TCGA	Lung Squamous Cell Carcinoma	0.0366	0.0188	2.3e-03	0.015	0.026	0.022	NA	0.018	6.2e-03	5.6e-04	1.5e-03	NA	3.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.4	0.7	0.6	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	0.8	0.3	-1.1
Depressed Affect (Nagel 2018)	0.6	1.3	3.5	-1.9	-0.6	0.1
Depression (Nagel 2018)	0.6	0.9	2.4	0.5	-1.6	-0.4
Intelligence (Savage-Jansen 2018)	0.9	2.6	4.0	-1.9	-0.2	-2.0
Neuroticism (Nagel 2018)	0.4	0.9	2.6	-1.6	-0.2	0.2
Schizophrenia (2018)	0.3	0.6	1.6	0.4	-0.1	-1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.4	-0.9	0.8
Worry (Nagel 2018)	0.5	1.1	1.9	-1.1	1.4	0.0
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	0.3	0.7	-0.8
Alzheimer’s Disease (in father)	0.4	0.5	1.1	1.0	-0.3	0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.4	0.7	0.6	-1.2
Crohns Disease (2017)	0.4	0.8	1.3	1.1	1.0	0.0
Irritable Bowel Disease (IBD)	0.4	0.9	1.3	-0.3	1.2	-1.1
Ulcerative Colitis (UC)	1.0	1.9	3.3	-1.8	0.3	-1.5
Major Depression (MDD)	0.4	0.4	1.2	1.1	-0.3	0.0
Reaction Time	0.6	1.2	2.8	-1.7	-0.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.9	-1.3	0.3	-1.4
Breast Cancer	0.4	1.0	2.8	0.3	-1.7	-0.3
Ovarian Cancer	0.7	0.9	1.4	1.1	1.2	0.5
Prostate Cancer	0.4	0.6	0.8	0.9	0.7	-0.5
Age at First Birth	1.3	1.9	2.6	-1.6	1.1	1.4
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.2	-0.7	0.5
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	0.3	-0.7	-1.6
Coronary Artery Disease (CAD)	0.6	0.7	1.2	0.8	1.1	-0.6
Crohns Disease (2012)	0.7	1.0	3.1	1.8	0.1	0.2
Mean Putamen Volume	2.0	2.3	4.4	1.6	-0.0	2.1
Fasting Glucose	0.4	0.5	0.9	-1.0	-0.5	-0.5
HbA1C	1.4	1.5	3.6	-0.6	-0.8	-1.9
HDL Cholesterol	0.1	0.2	0.4	0.6	-0.5	0.1
LDL Cholesterol	0.3	0.5	0.9	0.2	0.6	-1.0
Lupus	0.6	0.9	2.6	-0.4	0.4	-1.6
Neuroticism (2016)	0.1	0.1	0.3	-0.1	0.5	-0.1
Primary Biliary Cirrhosis	0.5	0.8	2.0	0.5	-0.2	1.4
Rheumatoid Arthritis	0.4	0.6	1.4	1.2	0.5	-0.3
Schizophrenia (2014)	0.5	1.1	1.8	0.9	-0.7	-1.4
Triglycerides	1.2	2.0	5.6	-2.4	0.7	0.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.3	0.3	1.5	-0.8
Ulcerative Colitis	0.3	0.5	0.9	-0.7	-0.1	-1.0
Blood Eosinophil Count	0.3	2.0	4.3	-2.1	-1.1	-0.7
Blood Platelet Count	0.3	3.2	6.1	0.0	2.5	1.9
Blood Red Count	0.3	2.7	6.3	1.4	2.5	0.1
Blood White Count	0.5	3.7	6.6	-1.1	-2.6	-1.8
Heel T-Score	0.3	2.6	6.5	-0.5	2.5	-1.1
BMI	0.3	1.5	2.8	1.2	-1.7	0.6
Height	1.0	18.7	47.3	2.8	-6.9	-0.9
Waist Hip Ratio (WHR)	0.1	0.7	1.8	-0.2	1.4	0.3
Systolic Blood Pressure	0.3	1.6	4.8	-0.4	2.2	0.1
Smoking Status	0.0	0.1	0.2	0.0	-0.4	0.2
Allergy or Eczema	0.3	0.7	1.7	-0.5	1.3	0.1
Cardiovascular Disease	0.0	0.1	0.2	0.4	-0.3	0.0
Hypothyroidism (self reported)	0.5	1.1	2.9	1.7	-0.3	-0.5
Respiratory disease	0.0	0.1	0.2	0.0	-0.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	0.1	-0.8	0.7
Lung FEV1/FVC ratio	0.2	1.0	2.3	-1.5	0.3	-0.7
Lung FVC	0.3	1.4	3.9	2.0	0.5	-0.3
Neuroticism	0.2	0.4	0.5	-0.7	0.4	0.7
Chronotype (morning person)	0.2	0.4	1.2	0.1	-1.1	0.2
Hair Pigment	0.0	0.9	2.2	1.5	0.2	-0.6
Tanning	0.3	4.1	5.5	-2.4	-2.4	1.1
Hand grip strength (left)	1.8	4.7	12.9	3.6	0.9	0.7
Number of treatments/medications taken	0.5	1.0	2.5	0.0	-1.6	-0.7
Average weekly spirits intake	1.0	1.3	2.3	-1.1	-0.4	1.5
Sensitivity / hurt feelings	0.5	0.9	1.1	-1.0	-1.1	0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.8	-0.3	-1.7	-0.1
Hearing difficulty/problems: Yes	0.2	0.2	0.4	0.5	-0.3	0.6
Relative age of first facial hair	0.1	0.1	0.2	-0.5	0.0	0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	0.9	-0.6	-1.0
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.6	-1.6	1.2	0.7
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.5	0.4	0.2
Systolic blood pressure, automated reading	0.4	1.1	1.8	-1.0	1.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.9	0.4	0.0	1.0
Angina	0.7	0.9	1.5	-0.2	-1.0	-1.2
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.2	0.9	-0.0
Vitamin and mineral supplements	0.2	0.3	0.6	-0.5	0.1	-0.8
Supplements: Zinc	0.6	0.7	1.2	-0.5	0.7	1.1
Medication: Co-codamol	0.3	0.3	0.5	-0.6	0.7	-0.3
Medication: Metformin	0.6	0.8	1.9	0.8	0.2	1.4
Diabetes (father)	0.3	0.4	1.3	1.1	0.0	-0.0
Diabetes (mother)	0.4	0.5	1.0	0.7	1.0	-0.2
Severe depression (siblings)	0.1	0.1	0.1	-0.3	0.4	0.4
Pack years adult smoking proportion	0.8	1.2	3.0	-0.6	-0.3	1.7
Impedance of leg (right)	3.1	15.1	22.0	-4.4	4.7	2.0
Leg fat-free mass (left)	3.0	15.8	32.1	3.9	-5.7	-0.5
Trunk fat percentage	0.1	0.5	0.9	0.7	-0.9	0.1
Hand grip strength (right)	1.5	4.1	10.5	3.2	1.2	0.7
Townsend deprivation index at recruitment	3.2	4.5	12.5	-3.5	-0.4	-0.8
Current tobacco smoking	0.1	0.2	0.5	0.0	0.1	-0.7
Average weekly fortified wine intake	2.4	2.8	7.8	0.4	-0.6	2.8
Maternal smoking around birth	0.3	0.4	0.7	-0.8	0.3	0.7
Fed-up feelings	0.9	1.6	2.8	-1.4	0.0	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.6	-1.6	-1.4	-0.7
Relative age voice broke	0.3	0.4	0.7	0.7	0.9	-0.1
Taking other prescription medications	0.1	0.2	0.3	0.5	-0.4	-0.0
Age when periods started (menarche)	0.7	1.8	4.4	-0.8	-0.5	2.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.8	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.5	1.9	1.3	-0.0
Tinnitus: Yes, but not now, but have in the past	4.6	4.9	6.5	-2.6	-1.8	2.2
Qualifications: CSEs or equivalent	0.7	1.0	2.6	0.1	0.6	-1.6
Serious illness, injury or assault to yourself	0.8	0.9	1.7	0.9	-0.5	1.3
High blood pressure	0.0	0.1	0.2	-0.2	-0.5	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	0.5	0.6
Multivitamins +/- minerals	0.4	0.5	0.8	0.6	0.6	0.9
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.1	-0.0	0.6
Supplements: Glucosamine	0.8	1.0	2.4	-0.8	-1.6	0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.1	-1.0	-0.6	1.0
Medication: Atenolol	0.6	0.7	1.2	-1.1	-1.0	-0.2
Medication: Levothyroxine sodium	0.5	0.8	1.5	1.2	-1.0	0.1
Sitting height	0.9	6.3	16.6	0.5	-4.1	-1.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.7	0.5	-0.0
High blood pressure (mother)	0.4	0.5	1.2	-1.1	0.2	-0.5
Body mass index (BMI)	0.4	1.7	3.6	1.2	-1.9	-0.1
Impedance of leg (left)	3.2	15.4	24.7	-4.4	5.0	1.5
Leg predicted mass (left)	2.9	15.3	31.2	3.8	-5.6	-0.5
Trunk fat mass	0.6	2.5	5.1	1.6	-2.3	-0.0
Waist circumference	0.7	2.4	5.7	1.2	-2.4	0.3
Number of incorrect matches in round	0.2	0.3	0.7	0.9	-0.2	-0.2
Past tobacco smoking	0.3	0.6	0.8	0.6	0.9	-0.6
Alcohol usually taken with meals	1.9	3.1	8.1	2.9	0.7	0.7
Nervous feelings	0.9	1.7	3.2	-1.2	1.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.9	-1.7	0.1	0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.6	0.7	0.4	0.8
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	-1.0	-0.7	-0.6
Had menopause	0.7	0.9	1.6	1.1	1.3	0.1
Had other major operations	0.5	0.6	1.7	0.0	-0.5	1.3
Forced vital capacity (FVC)	0.5	1.8	3.5	1.9	-1.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.6	1.6	0.7	0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.2	0.8	-0.4	-1.1
Qualifications: None of the above	0.1	0.2	0.3	-0.4	0.3	0.5
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.1	-1.2	0.7
Mouth/teeth dental problems	0.3	0.5	0.8	0.0	-0.9	0.7
Heart attack	0.5	0.7	1.2	1.1	0.4	-0.8
Allergy	0.1	0.2	0.4	0.2	-0.6	-0.3
Pain all over the body in last month	3.1	3.3	8.2	-0.0	1.3	-2.9
Diabetes (self-reported)	0.4	0.6	0.9	1.0	-0.3	0.9
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.4	-1.1	-1.2	0.5
Medication: Ramipril	1.0	1.2	2.1	1.0	0.8	-1.4
Medication: Simvastatin	1.1	1.6	2.4	1.4	1.6	-0.5
Fluid intelligence score	0.3	0.6	1.5	-0.0	0.5	-1.2
Illnesses of siblings	1.3	1.8	5.4	0.2	0.2	2.3
Neuroticism score	0.7	1.5	4.2	-2.0	0.2	0.4
Weight	1.3	6.4	13.8	2.3	-3.7	-0.3
Impedance of arm (right)	0.9	4.0	11.6	0.1	3.4	0.6
Arm fat percentage (right)	0.3	1.1	2.1	1.5	-1.0	0.4
Trunk fat-free mass	2.1	12.3	29.9	2.6	-5.5	-0.4
Hip circumference	1.1	4.6	10.9	1.7	-3.3	0.2
Time employed in main current job	1.2	1.3	2.8	-1.0	-0.4	-1.7
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.9	-0.6	0.0
Father’s age at death	0.6	0.8	1.5	-0.3	1.2	1.0
Worrier / anxious feelings	1.6	3.1	9.2	-3.0	-0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.5	-0.2	0.5
Falls in the last year	1.3	1.8	3.0	-1.2	-0.9	1.7
Hair/balding pattern: Pattern 3	0.6	1.0	2.0	1.4	-0.7	-0.6
Number of live births	0.6	0.9	2.5	-0.4	0.2	1.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.8	1.3	-1.1	0.4
Pulse rate	1.7	2.8	6.1	-2.5	-0.4	-1.4
Happiness	0.2	0.3	0.5	0.7	-0.6	0.2
Noisy workplace	1.2	1.5	2.8	-1.7	0.4	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.1	0.7	0.5	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	3.7	1.9	-1.2	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	0.6	-0.5	0.7	-0.8
Asthma	0.3	0.6	1.0	0.9	-0.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.9	-0.9	-0.8	0.8
Medication: Cholesterol lowering	0.2	0.4	1.1	1.1	0.1	-0.0
Depression (self-reported)	1.1	1.3	2.3	-1.5	0.6	-1.1
Medication: Lansoprazole	2.0	2.3	3.4	-1.3	1.8	-1.4
Prospective memory result	3.6	4.4	7.1	-2.7	-2.5	0.2
Lung cancer (father)	1.8	2.1	2.6	-1.3	1.5	-1.6
Illnesses of mother	0.1	0.1	0.4	-0.0	-0.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.9	1.3	-1.4	0.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.3	-0.7	-1.0	1.1
Impedance of arm (left)	0.8	3.7	10.8	0.4	3.3	-0.0
Arm fat mass (right)	0.8	3.4	6.2	2.0	-2.5	0.2
Trunk predicted mass	2.2	12.5	30.4	2.6	-5.5	-0.4
Standing height	0.9	9.2	20.1	2.7	-4.5	-0.6
Length of working week for main job	0.9	1.0	2.4	1.6	0.4	-0.5
Exposure to tobacco smoke at home	1.9	2.2	3.5	-1.6	-1.9	0.7
Breastfed as a baby	1.4	1.8	4.4	2.1	-0.4	-0.8
Tense / ‘highly strung’	0.9	1.5	2.6	-0.4	1.6	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	-0.9	0.3	-1.1
Hair/balding pattern: Pattern 4	0.9	2.2	4.8	0.5	2.2	1.2
Birth weight of first child	0.1	0.2	0.4	-0.0	-0.6	-0.3
Peak expiratory flow (PEF)	1.2	2.8	4.8	1.6	0.9	2.2
Pulse wave reflection index	2.3	2.9	3.5	1.9	-1.9	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	0.5	-0.7	-0.8
Loud music exposure frequency	1.2	1.3	3.5	-1.9	0.7	0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.9	1.3	1.4	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.6	-0.2	1.2
Blood clot in the leg (DVT)	1.0	1.3	2.0	-1.4	-1.3	0.5
Medication: Paracetamol	0.5	0.9	1.4	-1.2	-0.4	-1.0
Headache pain in last month	0.2	0.4	0.8	-0.1	-0.6	0.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.6	0.1	-0.3
Glaucoma (self-reported)	1.0	1.2	2.2	1.5	-1.1	0.5
Gout (self-reported)	0.3	0.4	0.7	-0.0	-0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.6	1.6	-0.5	0.5
Medication: Amlodipine	1.1	1.5	2.6	-0.5	1.3	-1.6
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.4	-1.8	-1.4	-0.8
Birth weight	0.6	1.4	2.8	1.7	-0.6	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	-0.2	0.1	1.1
High blood pressure (siblings)	1.0	1.4	3.2	-1.0	0.0	-1.8
Forced vital capacity (FVC), Best measure	0.7	2.7	4.5	2.1	-1.9	-0.1
Body fat percentage	0.1	0.3	0.4	0.4	-0.7	0.6
Leg fat percentage (right)	0.2	0.7	1.0	-1.0	0.5	1.0
Arm fat-free mass (right)	2.0	10.3	27.4	1.9	-5.2	-0.2
Exposure to tobacco smoke outside home	0.8	1.1	1.9	-0.1	-1.4	1.1
Comparative body size at age 10	1.2	3.3	4.3	2.1	-2.0	1.4
Number of full brothers	1.0	1.3	2.6	-0.6	1.6	-1.0
Worry too long after embarrassment	0.6	0.9	2.7	-1.6	-0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.7	-0.8	-0.9	2.2
Wheeze or whistling in the chest in last year	0.7	1.3	3.8	-0.0	-1.9	-0.3
Number of children fathered	1.4	1.6	4.8	-0.0	-0.2	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	3.4	3.9	6.1	2.5	1.9	-1.4
Age at first live birth	0.6	1.0	2.6	-0.3	-0.5	1.6
Pulse wave peak to peak time	0.8	0.9	1.4	0.9	0.8	-1.2
Health satisfaction	0.4	0.5	1.0	1.0	0.3	-0.7
Shortness of breath walking on level ground	0.7	0.9	2.4	0.3	-0.3	-1.6
Qualifications: College or University degree	0.1	0.4	1.0	1.0	-0.1	-0.4
Eye problems/disorders: None of the above	1.9	2.1	2.6	-1.6	1.5	1.2
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.1	0.2	2.0	-0.8
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	0.4	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	0.1	1.0	0.7
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.4	0.0	-0.6
Medication: Blood pressure	0.1	0.2	0.5	0.7	0.3	-0.3
Angina (self-reported)	0.7	0.9	1.7	0.2	-1.0	-1.3
Migraine (self-reported)	2.0	2.5	3.8	-1.9	-1.9	-0.4
Medication: Ibuprofen	0.8	1.0	2.2	-1.5	-0.7	0.4
Medication: Allopurinol	0.2	0.3	0.6	0.8	0.1	-0.5
Medication: Omeprazole	0.9	1.1	2.1	-0.6	-1.4	1.0
Medication: Seretide 50 evohaler	0.9	1.0	1.5	-1.2	-0.7	1.0
Mean time to correctly identify matches	0.6	1.1	2.7	-1.6	-0.0	-0.8
Heart disease (mother)	1.2	1.5	3.0	-0.3	-1.2	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.4	1.5	0.2	-0.7
Whole body fat mass	0.6	2.3	5.0	1.4	-2.2	0.2
Leg fat mass (right)	0.3	1.3	3.0	0.7	-1.7	0.7
Arm predicted mass (right)	2.1	10.7	30.0	1.4	-5.5	-0.5
Pulse rate, automated reading	0.6	2.0	4.8	-2.2	-0.1	-1.1
Alcohol intake frequency.	0.2	0.6	1.5	0.5	-0.2	-1.2
Comparative height size at age 10	0.8	4.7	7.2	2.2	-2.7	1.3
Number of full sisters	1.2	1.4	2.0	-1.4	-0.7	-1.4
Suffer from ‘nerves’	0.8	1.3	3.9	0.0	2.0	0.1
Overall health rating	0.6	1.3	1.8	-0.9	-1.2	-1.3
Chest pain or discomfort	0.3	0.4	1.0	-0.2	0.6	-1.0
Had major operations	0.2	0.2	0.4	0.2	-0.3	-0.7
Age at last live birth	0.3	0.5	0.7	-0.6	-0.6	0.8
Family relationship satisfaction	0.9	1.1	2.4	0.9	-1.6	0.3
Leg pain on walking	0.8	1.0	1.5	-1.2	-1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.8	-0.5	-0.7	-1.7
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.1	1.2	0.2	1.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.7	1.2	1.3	0.2
Medication: Aspirin	0.8	1.1	1.9	0.9	-0.7	-1.4
Supplements: Vitamin C	1.4	1.7	3.6	-1.9	-1.0	0.7
Knee pain experienced in last month	1.6	2.4	4.7	0.2	-2.2	1.6
Hypertension (Self-reported)	0.0	0.1	0.3	-0.2	-0.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	2.8	-1.7	1.7	-1.4
Illnesses of father: Heart disease	1.1	1.5	2.3	-0.3	-1.5	1.4
Illnesses of siblings: Diabetes	1.3	1.6	3.7	1.9	1.0	-0.4
Smoking status: Previous	0.6	0.8	1.4	-0.9	-0.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.8	-0.1	-1.7	0.3
Whole body fat-free mass	2.5	14.4	32.9	3.2	-5.7	-0.5
Leg fat-free mass (right)	3.1	16.6	32.4	4.0	-5.7	-1.1
Arm fat percentage (left)	0.3	1.3	2.7	1.6	-1.1	0.1
Average weekly red wine intake	1.4	2.0	5.0	-0.7	-2.2	0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	0.4	1.2	-0.2
Mood swings	0.3	0.5	0.9	-1.0	0.1	0.8
Loneliness, isolation	1.1	1.5	3.6	-1.9	-1.0	-0.1
Long-standing illness, disability or infirmity	0.4	0.6	1.2	-0.1	-0.7	-1.1
Ever had bowel cancer screening	3.0	3.6	10.0	0.8	-0.1	3.2
Diabetes diagnosed by doctor	0.3	0.5	0.7	0.8	-0.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.1	0.9	-0.2	1.1
Friendships satisfaction	2.4	2.9	7.2	1.3	-0.2	2.7
Qualifications: nursing, teaching	0.4	0.7	0.9	0.9	0.4	1.0
Commuting to job workplace: Walk	1.3	1.4	2.4	-1.6	-1.2	-0.6
Eye problems/disorders: Cataract	1.6	1.8	4.5	0.1	-0.9	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.2	0.0	2.0	0.9
Medication for cholesterol	1.2	1.8	3.8	-0.1	-1.2	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	5.4	0.8	-1.1	-2.3
Back pain experienced in last month	1.3	1.8	4.5	-2.1	-0.1	-1.0
Mineral and other dietary supplements	0.1	0.2	0.3	-0.4	0.5	-0.2
Breast cancer (self-reported)	0.1	0.2	0.2	-0.5	-0.3	0.4
Asthma (self-reported)	0.2	0.3	0.4	0.6	-0.5	0.6
Osteoporosis (self-reported)	0.2	0.2	0.4	0.6	-0.2	-0.5
Osteoarthritis (self-reported)	3.1	4.0	9.7	-0.6	-1.5	-3.1
Medication: Aspirin	0.6	0.8	1.6	0.6	-0.5	-1.3
Medication: Gliclazide	0.2	0.2	0.3	-0.4	-0.2	-0.5
Illnesses of father: None of the above (group 1)	1.1	1.4	3.2	1.8	0.9	-0.3
Smoking status: Current	0.1	0.1	0.3	0.1	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.4	-0.4	-0.3
Whole body water mass	2.5	14.1	32.7	3.0	-5.7	-0.5
Leg predicted mass (right)	3.1	16.3	31.7	4.0	-5.6	-1.1
Arm fat mass (left)	0.8	3.5	6.3	2.0	-2.5	0.0
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.0	-0.8	-0.8
Average weekly champagne plus white wine intake	2.8	3.9	10.2	0.7	-1.0	3.2
Miserableness	1.0	1.7	4.2	-2.1	-0.4	-0.8
Guilty feelings	1.4	2.1	5.1	-2.3	-1.0	-0.1
Wears glasses or contact lenses	0.1	0.1	0.2	0.2	0.5	-0.3
Ever taken oral contraceptive pill	1.0	1.1	2.1	-0.2	-1.1	1.5
Hearing aid user	0.0	0.0	0.1	0.2	-0.0	0.3
Mother’s age at death	0.5	0.7	1.7	0.1	-0.5	-1.3
Financial situation satisfaction	1.2	1.5	3.1	1.0	-1.8	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.3	0.2	-0.2	1.8
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.9	-0.2	-0.6
Eye problems/disorders: Glaucoma	0.9	1.0	2.3	1.5	-0.6	-0.6
Medication: Blood pressure	1.0	1.9	5.0	-0.9	0.0	-2.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.5	-0.1	0.8
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.0	-0.2	0.7
High cholesterol (Self-reported)	0.3	0.6	1.2	1.1	0.8	-0.0
Medication: Bendroflumethiazide	0.3	0.4	0.9	-0.5	-0.2	-1.0
Medication: Paracetamol	1.0	1.5	1.7	-1.2	-1.3	-1.2
Medication: Lisinopril	0.3	0.4	0.5	0.7	0.7	0.0
Medication: Atorvastatin	1.4	1.8	4.2	-1.0	-2.1	0.4
Illnesses of father: High blood pressure	1.4	1.7	2.2	-1.0	-1.5	1.3
Alcohol drinker status: Never	0.0	0.0	0.1	-0.2	0.3	-0.1
Ever smoked	0.2	0.4	1.0	-0.1	-1.0	0.4
Basal metabolic rate	2.3	12.8	28.9	3.0	-5.4	-0.5
Leg fat percentage (left)	0.1	0.4	0.7	-0.8	0.5	0.7
Arm fat-free mass (left)	2.1	10.6	28.8	1.7	-5.4	0.1
Number of operations (self-reported)	0.2	0.4	0.8	0.9	0.5	0.1
Average weekly beer plus cider intake	2.3	3.3	5.2	-2.3	1.4	-1.6
Irritability	0.4	0.6	1.3	0.7	-1.1	0.3
Risk taking	0.5	0.8	1.5	-0.6	0.8	1.2
Ever had prostate specific antigen (PSA) test	1.5	1.8	2.5	1.2	1.1	1.6
Fractured/broken bones in last 5 years	1.4	1.8	4.5	2.1	1.0	-0.1
Age started oral contraceptive pill	1.4	1.7	4.6	-0.7	-0.0	2.1
Diastolic blood pressure, automated reading	0.4	1.1	2.2	-1.0	-1.5	-0.3
Ever depressed for a whole week	0.3	0.4	1.0	-0.1	-0.6	-1.0
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.3	0.0	0.3
Commuting to job workplace: Cycle	1.8	2.2	6.5	2.5	-0.3	-0.0
Myopia	0.9	1.4	3.8	0.4	-0.4	1.9
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.2	0.2	0.5	0.5
Cholesterol lowering medication	1.7	2.4	3.2	1.6	1.3	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.1	-0.8	0.7
Pain experienced in last month	0.7	1.1	2.8	0.5	1.7	0.5
Supplements: Calcium	0.2	0.2	0.6	-0.3	-0.1	-0.8
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.2	-0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.4	1.2	0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.1	-1.2	-1.4	0.6
Heart disease (siblings)	1.1	1.4	3.1	-1.0	-0.4	-1.8
Alcohol drinker status: Previous	0.8	0.9	1.7	1.3	0.1	1.0
Pack years of smoking	0.7	1.0	2.4	-0.7	-0.4	1.5
Impedance of whole body	1.5	7.7	17.3	-2.3	4.2	0.7
Leg fat mass (left)	0.3	1.2	3.0	0.7	-1.7	0.4
Arm predicted mass (left)	2.1	10.5	29.7	1.3	-5.5	-0.1