Hub : Genes

KCNJ16

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.069	0.027	1.7e-03	0.037	0.028	0.017	0.039	0.029	2.1e-05	2.3e-04	3.1e-03	1.4e-05	1.4e-04
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.070	0.035	2.3e-03	0.016	0.022	0.014	NA	0.012	4.0e-02	2.0e-02	5.3e-02	NA	6.6e-02
3	TCGA	Stomach Adenocarcinoma	0.051	0.026	1.3e-03	0.050	0.017	0.035	NA	0.050	1.6e-04	1.9e-02	1.4e-03	NA	1.7e-04
4	TCGA	Thyroid Carcinoma	0.089	0.032	3.0e-06	0.028	0.052	0.058	NA	0.064	9.5e-04	7.4e-06	2.5e-06	NA	6.9e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	0.8	0.9	0.9	-0.8	0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	0.5	0.3	-0.8	1.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	0.2	0.8	1.1	-1.2
Depression (Nagel 2018)	0.2	0.2	0.6	0.3	0.8	0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.9	-1.4	0.2	1.1	-1.3
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-0.4	0.9	0.8	-0.5
Schizophrenia (2018)	0.2	0.4	1.5	-0.0	-0.4	-0.4	1.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.5	0.4	0.2	-0.1
Worry (Nagel 2018)	0.4	0.9	1.3	-0.6	1.1	1.1	-0.9
Alzheimer’s Disease (in mother)	0.8	1.0	1.5	0.6	1.2	0.7	-1.2
Alzheimer’s Disease (in father)	0.9	1.0	1.7	-0.9	-1.3	1.3	-0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	-0.6	-0.5	0.9	-0.9
Crohns Disease (2017)	0.7	1.4	4.1	-0.1	0.4	1.2	-2.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	0.5	0.5	-0.1	-1.2
Ulcerative Colitis (UC)	0.3	0.6	1.5	0.9	0.3	-1.2	0.2
Major Depression (MDD)	0.8	1.0	2.7	-0.1	0.3	1.1	-1.6
Reaction Time	2.3	4.3	6.7	-2.6	-0.4	2.4	-2.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.6	-1.6	-0.3	0.4	-0.1
Breast Cancer	4.2	10.1	15.2	-2.4	-3.6	3.9	-2.6
Ovarian Cancer	0.3	0.4	0.7	-0.8	-0.7	0.5	0.5
Prostate Cancer	1.0	1.4	2.4	-0.6	-1.1	1.6	-1.3
Age at First Birth	0.3	0.5	0.9	-0.9	-0.3	0.2	1.0
Bipolar Disorder (2011)	0.6	0.6	1.6	1.2	0.6	-0.6	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	0.9	-0.9	-0.2	1.0	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.3	0.1	-0.4	0.8
Crohns Disease (2012)	0.8	1.2	3.7	0.1	0.8	0.8	-1.9
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.0	0.0	-0.1
Fasting Glucose	0.8	0.9	1.4	-0.8	0.8	-1.2	1.0
HbA1C	0.4	0.4	1.4	-0.3	1.2	-0.4	-0.0
HDL Cholesterol	0.1	0.1	0.4	-0.2	0.1	0.1	-0.6
LDL Cholesterol	0.3	0.5	1.6	0.0	-1.3	0.2	0.7
Lupus	1.7	2.6	5.7	-2.4	-1.7	1.3	-0.1
Neuroticism (2016)	0.3	0.4	0.9	0.0	0.9	0.9	-0.1
Primary Biliary Cirrhosis	1.3	1.9	2.8	1.5	1.7	-1.5	0.5
Rheumatoid Arthritis	0.9	1.2	3.8	0.6	1.9	-0.7	-0.3
Schizophrenia (2014)	0.1	0.2	0.6	-0.0	-0.4	-0.1	0.8
Triglycerides	0.0	0.1	0.1	0.4	0.2	-0.3	-0.1
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.3	0.7	1.5	0.4	-1.8
Ulcerative Colitis	0.5	0.7	1.4	0.8	0.2	-1.2	-0.9
Blood Eosinophil Count	0.2	1.5	4.0	0.9	-2.0	0.0	1.1
Blood Platelet Count	0.0	0.1	0.2	-0.5	-0.2	0.0	0.3
Blood Red Count	0.0	0.1	0.2	0.4	-0.2	-0.0	-0.2
Blood White Count	0.1	0.7	1.6	-1.3	0.9	0.5	0.3
Heel T-Score	0.9	7.0	11.0	-3.1	-3.3	2.5	-1.1
BMI	0.2	1.0	1.9	-0.2	0.9	1.4	-1.1
Height	2.1	41.2	88.5	6.3	9.4	-4.9	-3.6
Waist Hip Ratio (WHR)	0.2	0.8	1.7	0.7	-0.8	-0.5	-1.3
Systolic Blood Pressure	0.8	4.2	8.1	-1.6	-2.9	2.3	-0.7
Smoking Status	0.1	0.2	0.6	-0.8	-0.2	0.1	0.1
Allergy or Eczema	1.2	3.0	5.6	-0.8	-2.4	2.3	-0.6
Cardiovascular Disease	0.0	0.2	0.5	0.7	-0.4	0.0	-0.1
Hypothyroidism (self reported)	0.7	1.6	2.9	-1.5	-1.7	0.9	0.5
Respiratory disease	4.3	9.5	11.9	-2.9	-3.2	3.5	-2.8
Type 2 Diabetes (T2D) (2018)	4.2	7.9	13.4	-3.2	-1.9	3.7	-2.0
Lung FEV1/FVC ratio	0.2	1.2	1.9	1.1	1.4	-1.2	-0.3
Lung FVC	0.2	0.8	2.7	0.6	-0.6	0.1	1.6
Neuroticism	0.7	1.6	3.9	-0.7	0.7	1.3	-2.0
Chronotype (morning person)	0.0	0.1	0.2	0.3	0.3	0.5	0.1
Hair Pigment	0.1	3.3	6.1	-2.0	-2.5	1.2	1.2
Tanning	0.0	0.4	0.9	-0.9	-0.9	0.3	-0.1
Hand grip strength (left)	2.5	6.7	13.6	3.7	2.9	-2.1	0.2
Number of treatments/medications taken	1.2	2.2	4.2	-2.0	-1.6	1.4	-0.5
Average weekly spirits intake	1.2	1.5	4.3	-0.2	-1.0	-0.9	2.1
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.4	-0.0	0.5	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	0.3	0.8	0.0	-0.4
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.3	-0.0	0.1	-0.4
Relative age of first facial hair	2.4	5.0	14.5	-2.0	-3.8	1.1	0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	0.5	-0.5	-1.3	1.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.2	-1.8	-1.3	0.4	0.7
Ever had hysterectomy (womb removed)	1.0	1.1	3.1	0.6	1.8	-0.2	-0.9
Systolic blood pressure, automated reading	1.7	5.0	8.8	-3.0	-2.6	2.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	3.1	0.3	-0.0	-0.7	1.8
Angina	0.1	0.2	0.3	-0.5	-0.5	-0.3	-0.1
Medication for hormone replacement therapy	0.9	1.0	2.5	0.4	1.6	-1.0	0.5
Vitamin and mineral supplements	0.1	0.1	0.3	0.1	-0.2	0.5	0.1
Supplements: Zinc	0.0	0.0	0.1	-0.3	0.0	-0.3	0.0
Medication: Co-codamol	1.2	1.4	2.5	0.9	0.2	-1.4	1.6
Medication: Metformin	3.3	4.6	8.3	-2.9	-1.8	2.5	-0.8
Diabetes (father)	0.5	0.7	1.2	-0.5	0.8	-1.1	0.8
Diabetes (mother)	2.9	3.7	5.9	-2.4	0.7	1.8	-2.3
Severe depression (siblings)	2.6	2.9	3.9	1.9	2.0	-1.9	0.9
Pack years adult smoking proportion	0.1	0.1	0.3	0.3	0.3	0.5	0.0
Impedance of leg (right)	0.3	1.3	2.0	1.3	-1.1	-1.4	0.5
Leg fat-free mass (left)	2.0	10.5	28.5	2.8	5.3	-1.0	-2.1
Trunk fat percentage	0.0	0.1	0.3	0.0	-0.1	0.4	-0.5
Hand grip strength (right)	0.8	2.1	4.7	2.2	1.4	-1.4	-0.1
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.2	0.6	0.1	-0.8
Current tobacco smoking	0.2	0.3	0.6	-0.4	-0.4	0.8	0.3
Average weekly fortified wine intake	0.9	1.0	3.4	-0.6	-1.8	-0.0	0.6
Maternal smoking around birth	1.2	1.7	4.2	-0.8	0.3	1.4	-2.1
Fed-up feelings	0.6	1.0	1.8	0.7	0.9	1.0	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.3	1.5	1.3	-1.2	0.1
Relative age voice broke	0.9	1.4	2.7	-0.9	-1.6	1.4	-0.7
Taking other prescription medications	0.8	1.2	2.4	-1.4	-1.6	0.5	0.5
Age when periods started (menarche)	0.7	1.6	2.8	-0.7	-1.0	1.5	-1.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	-0.2	0.9	-0.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.6	-1.8	-0.9	1.3	-1.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.6	0.8	0.5	-0.6	-0.5
Qualifications: CSEs or equivalent	0.4	0.5	1.3	0.6	0.7	-0.0	-1.1
Serious illness, injury or assault to yourself	0.0	0.1	0.1	0.3	-0.2	0.3	0.1
High blood pressure	0.3	1.0	1.9	-0.8	-1.1	1.4	-0.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.9	-0.4	-1.7	2.2	-1.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.0	0.0	0.0
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.2	0.5	-0.8	-0.8
Supplements: Glucosamine	1.6	2.1	4.5	-0.3	-1.3	-1.5	2.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.0	-1.5	-1.7	0.3	-0.3
Medication: Atenolol	0.9	1.1	2.2	-0.7	-1.1	1.5	-0.7
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.2	-0.1	0.0	0.1
Sitting height	2.6	18.2	44.4	3.9	6.7	-3.4	-1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	1.3	1.1	0.2	-0.2
High blood pressure (mother)	1.1	1.6	3.9	-2.0	-1.2	1.0	-0.1
Body mass index (BMI)	0.2	0.6	1.4	-0.6	0.6	1.2	-0.7
Impedance of leg (left)	0.3	1.5	2.6	1.4	-1.1	-1.6	0.4
Leg predicted mass (left)	2.0	10.3	27.8	2.9	5.3	-1.0	-2.1
Trunk fat mass	0.4	1.6	3.5	1.3	1.9	-0.4	-1.0
Waist circumference	0.4	1.3	2.4	1.2	1.5	0.2	-1.2
Number of incorrect matches in round	0.2	0.3	0.6	0.1	-0.3	0.8	-0.6
Past tobacco smoking	0.1	0.2	0.7	0.8	0.1	0.3	0.4
Alcohol usually taken with meals	0.7	1.1	2.1	0.7	0.1	-1.5	1.4
Nervous feelings	0.1	0.2	0.6	-0.8	0.5	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.1	2.0	1.8	0.3	-1.4
Hearing difficulty/problems with background noise	0.8	1.3	2.0	-1.1	-1.2	1.4	-0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.5	-0.9	-0.0	0.2
Had menopause	1.1	1.4	3.4	-1.8	-0.8	1.2	-0.4
Had other major operations	1.2	1.5	3.3	-0.5	0.2	1.5	-1.8
Forced vital capacity (FVC)	2.3	8.9	15.1	3.9	3.6	-2.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	7.5	-2.7	-1.1	1.8	-2.0
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	6.2	-1.3	-0.8	2.5	-2.1
Qualifications: None of the above	0.3	0.6	1.0	-0.8	0.2	0.9	-1.0
Financial difficulties in last 2 years	1.7	2.2	4.3	1.2	0.6	-2.1	1.7
Mouth/teeth dental problems	0.8	1.3	3.1	0.9	0.8	-1.8	0.7
Heart attack	1.5	1.9	4.7	-1.6	-2.2	0.4	0.4
Allergy	2.5	5.7	11.3	1.4	2.6	-3.4	1.6
Pain all over the body in last month	1.1	1.2	3.4	-0.1	0.3	1.1	-1.8
Diabetes (self-reported)	1.0	1.6	2.7	-1.6	-0.8	1.3	-1.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.3	-0.7	0.7	0.4
Medication: Ramipril	2.4	3.1	8.6	-2.9	-1.7	1.0	-0.3
Medication: Simvastatin	0.6	0.8	1.5	-0.5	-1.2	0.7	-1.1
Fluid intelligence score	0.9	2.0	4.8	-2.2	-1.2	0.5	1.2
Illnesses of siblings	0.8	1.1	2.1	1.4	1.1	-0.2	-0.9
Neuroticism score	0.3	0.6	0.9	0.1	1.0	0.8	-1.0
Weight	1.3	6.4	17.1	2.2	4.1	-0.9	-1.7
Impedance of arm (right)	0.4	2.0	5.4	-0.1	-2.3	-0.5	1.5
Arm fat percentage (right)	0.0	0.1	0.4	-0.2	-0.0	0.6	-0.0
Trunk fat-free mass	3.3	19.1	48.6	4.1	7.0	-2.4	-2.4
Hip circumference	0.7	2.9	8.7	1.4	2.9	0.1	-1.0
Time employed in main current job	1.3	1.5	2.8	1.0	-1.4	-0.5	1.7
Alcohol intake versus 10 years previously	0.7	1.1	2.5	0.7	1.1	0.4	-1.6
Father’s age at death	0.8	1.0	2.0	-1.4	-0.8	1.1	-0.5
Worrier / anxious feelings	0.6	1.1	2.6	-1.6	0.4	1.0	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	1.1	1.1	-0.4	-0.4
Falls in the last year	1.2	1.6	3.8	-0.8	-1.0	2.0	-1.0
Hair/balding pattern: Pattern 3	0.7	1.0	2.9	0.2	0.3	-1.1	1.7
Number of live births	3.1	4.4	6.5	-2.5	-1.1	2.5	-1.9
Forced expiratory volume in 1-second (FEV1)	2.6	8.9	16.2	4.0	3.7	-2.4	0.4
Pulse rate	1.4	2.3	5.1	1.1	2.2	-1.7	0.2
Happiness	0.1	0.2	0.4	-0.1	0.7	-0.2	-0.3
Noisy workplace	0.5	0.6	0.8	0.8	0.9	-0.0	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.3	1.1	0.8	-1.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	0.4	1.2	-0.0	-1.2
Mouth/teeth dental problems: Dentures	2.0	3.3	6.8	-1.7	-1.3	2.6	-1.3
Asthma	3.4	6.6	10.0	-2.4	-1.7	3.2	-2.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	1.0	0.8	0.1	-0.9
Medication: Cholesterol lowering	2.1	3.3	5.9	-1.3	-2.4	1.7	-1.6
Depression (self-reported)	0.6	0.8	2.4	0.1	0.8	0.3	-1.6
Medication: Lansoprazole	0.4	0.5	1.3	-0.6	-0.4	0.0	1.1
Prospective memory result	0.2	0.3	1.0	-0.2	-0.4	0.1	-1.0
Lung cancer (father)	0.2	0.3	0.7	0.4	0.8	-0.5	-0.3
Illnesses of mother	0.1	0.1	0.4	0.7	0.1	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.5	18.7	4.3	3.5	-2.5	0.8
Pulse wave Arterial Stiffness index	2.1	2.5	4.8	1.4	2.2	-1.6	-0.7
Impedance of arm (left)	0.4	2.0	5.8	-0.9	-2.4	-0.2	1.2
Arm fat mass (right)	0.3	1.1	3.1	0.7	1.8	0.2	-0.9
Trunk predicted mass	3.2	18.5	47.5	4.0	6.9	-2.3	-2.4
Standing height	3.0	29.4	60.8	5.8	7.8	-4.0	-2.6
Length of working week for main job	0.6	0.6	1.5	0.1	1.0	-1.2	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.6	0.1	0.1	0.1
Breastfed as a baby	1.3	1.6	3.5	1.4	0.2	-1.9	0.9
Tense / ‘highly strung’	0.2	0.4	0.8	-0.2	0.2	0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	6.1	-0.3	0.5	2.5	-1.4
Hair/balding pattern: Pattern 4	1.1	2.6	7.0	-0.1	1.3	1.3	-2.6
Birth weight of first child	0.8	1.4	3.1	1.3	1.7	-1.1	0.2
Peak expiratory flow (PEF)	1.5	3.5	5.6	2.4	2.2	-1.7	0.9
Pulse wave reflection index	0.2	0.2	0.7	0.1	-0.9	0.4	-0.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-0.4	0.6	1.2	-1.1
Loud music exposure frequency	0.2	0.3	0.6	0.5	-0.8	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	-0.4	-0.5	0.5	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	-0.1	-0.6	-0.2	0.7
Blood clot in the leg (DVT)	0.3	0.5	1.0	-0.4	-0.7	0.3	1.0
Medication: Paracetamol	0.6	1.0	2.7	-0.4	0.5	0.9	-1.6
Headache pain in last month	0.5	0.9	2.9	0.3	0.6	0.6	-1.7
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	6.2	1.5	1.8	-2.5	1.5
Glaucoma (self-reported)	1.2	1.4	2.9	-0.7	-1.4	0.2	1.7
Gout (self-reported)	0.4	0.5	1.1	1.0	0.1	-1.0	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	-0.7	-0.9	0.5	0.6
Medication: Amlodipine	0.9	1.3	3.4	-0.7	0.7	1.9	-0.8
Medication: Ventolin 100micrograms inhaler	2.3	2.9	5.9	-2.4	-1.4	1.5	-1.4
Birth weight	1.9	4.1	7.2	2.3	2.7	-1.9	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.4	0.1	0.9	-1.0
High blood pressure (siblings)	1.0	1.4	3.2	-1.1	-1.1	0.3	1.8
Forced vital capacity (FVC), Best measure	2.2	7.9	15.0	3.9	3.4	-2.3	0.5
Body fat percentage	0.0	0.1	0.1	0.3	0.2	0.1	-0.4
Leg fat percentage (right)	0.0	0.1	0.2	0.5	0.2	-0.5	0.2
Arm fat-free mass (right)	2.8	14.1	35.9	3.2	6.0	-1.7	-2.7
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.4	0.6	0.1	0.3
Comparative body size at age 10	1.5	4.2	8.6	2.6	2.9	-1.1	-0.2
Number of full brothers	0.2	0.2	0.5	-0.4	-0.7	0.1	-0.4
Worry too long after embarrassment	0.6	1.0	2.4	0.8	-0.0	-0.9	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.9	1.4	2.2	-0.1	-1.4
Wheeze or whistling in the chest in last year	1.6	2.8	4.8	-1.4	-1.0	2.2	-1.8
Number of children fathered	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	5.7	1.6	1.7	-2.4	1.6
Age at first live birth	0.8	1.5	3.0	1.7	1.3	-0.9	-0.7
Pulse wave peak to peak time	1.1	1.3	2.3	-0.9	-1.5	1.2	0.7
Health satisfaction	0.3	0.4	0.9	0.9	0.5	-0.8	-0.0
Shortness of breath walking on level ground	4.2	5.0	11.5	-1.8	-0.5	2.2	-3.4
Qualifications: College or University degree	0.2	0.7	2.0	0.3	0.1	-1.4	0.9
Eye problems/disorders: None of the above	0.8	1.0	1.4	1.2	1.1	-0.9	-0.8
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.1	0.0	0.3	-0.3
Emphysema/chronic bronchitis	2.5	2.8	6.3	-1.6	-2.5	1.5	0.3
Medication for pain relief, constipation, heartburn	1.1	1.8	3.0	1.6	0.9	-1.1	1.7
Neck or shoulder pain in last month	1.6	2.3	5.6	-1.5	-2.4	1.0	0.8
Medication: Blood pressure	1.8	3.2	7.2	-1.7	-1.1	2.7	-1.1
Angina (self-reported)	0.1	0.2	0.3	-0.6	-0.6	-0.3	-0.0
Migraine (self-reported)	0.2	0.2	0.6	-0.3	-0.4	0.8	-0.0
Medication: Ibuprofen	0.9	1.1	1.7	1.3	1.1	-0.0	-1.2
Medication: Allopurinol	0.3	0.5	0.8	-0.6	-0.9	-0.6	-0.5
Medication: Omeprazole	0.4	0.5	1.2	-0.2	-1.1	0.6	0.6
Medication: Seretide 50 evohaler	0.9	1.0	1.5	-1.2	-1.1	1.0	-0.6
Mean time to correctly identify matches	2.1	4.1	8.0	-2.8	-0.5	2.1	-1.9
Heart disease (mother)	1.2	1.5	2.8	1.7	0.6	-1.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.4	-0.3	-1.9	0.8	0.7
Whole body fat mass	0.4	1.6	3.7	1.3	1.9	-0.3	-1.0
Leg fat mass (right)	0.6	2.5	5.7	1.8	2.4	-0.9	-0.5
Arm predicted mass (right)	2.9	14.9	38.8	3.3	6.2	-1.5	-2.8
Pulse rate, automated reading	0.4	1.2	4.2	-0.3	2.0	-0.5	-0.2
Alcohol intake frequency.	0.3	0.6	1.8	-0.1	-0.3	0.7	-1.4
Comparative height size at age 10	2.6	14.1	32.7	3.8	5.7	-3.1	-0.1
Number of full sisters	0.2	0.3	0.6	-0.7	-0.8	-0.0	0.2
Suffer from ‘nerves’	2.5	3.9	10.6	1.7	3.2	-1.4	-0.1
Overall health rating	0.1	0.2	0.3	0.5	0.4	0.2	-0.5
Chest pain or discomfort	0.5	0.8	1.4	-1.1	-1.2	-0.3	0.6
Had major operations	0.5	0.6	1.8	0.3	1.3	-0.6	0.2
Age at last live birth	0.2	0.3	0.7	0.5	0.2	-0.8	0.3
Family relationship satisfaction	0.8	1.0	2.3	-0.1	0.4	1.2	-1.5
Leg pain on walking	0.9	1.1	2.5	1.4	1.6	0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	-0.9	-1.2	0.7	0.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.3	-1.0	-1.8	-0.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.3	-0.5	0.4	-0.1
Medication: Aspirin	3.4	4.4	9.7	-2.7	-3.1	1.0	0.1
Supplements: Vitamin C	0.9	1.1	1.8	-1.1	-0.6	0.9	-1.4
Knee pain experienced in last month	0.5	0.8	2.1	-0.7	-1.4	0.8	-0.0
Hypertension (Self-reported)	0.3	0.8	1.6	-0.9	-1.3	0.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.1	-0.4	-0.3	-0.1	1.4
Illnesses of father: Heart disease	1.7	2.4	5.0	-1.9	-2.2	0.9	-0.5
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.7	-0.0	0.4	0.2
Smoking status: Previous	0.2	0.3	0.8	-0.4	0.5	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	11.3	2.2	3.4	-1.2	-1.6
Whole body fat-free mass	2.9	16.5	42.8	3.7	6.5	-1.8	-2.4
Leg fat-free mass (right)	1.8	9.8	26.8	2.6	5.2	-0.9	-2.2
Arm fat percentage (left)	0.1	0.3	0.6	-0.6	-0.0	0.8	-0.2
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.5	-0.4	-0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	-0.9	-0.5	0.5	-1.1
Mood swings	0.2	0.4	0.9	-0.1	0.4	0.7	-1.0
Loneliness, isolation	0.5	0.7	1.2	0.4	0.7	1.0	-1.1
Long-standing illness, disability or infirmity	1.9	2.9	4.0	-1.7	-1.1	2.0	-1.8
Ever had bowel cancer screening	0.8	0.9	1.1	1.0	1.1	-1.0	0.8
Diabetes diagnosed by doctor	2.1	3.4	5.3	-2.1	-1.1	2.3	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	0.0	-1.0	0.2	-0.0
Friendships satisfaction	0.7	0.8	1.8	1.1	1.4	0.2	-0.4
Qualifications: nursing, teaching	1.1	1.7	4.5	-0.6	-0.6	-1.3	2.1
Commuting to job workplace: Walk	0.6	0.6	1.3	-1.0	0.4	0.5	-1.1
Eye problems/disorders: Cataract	0.8	0.9	1.9	-1.1	-0.6	1.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.5	0.4	0.8	-0.1
Medication for cholesterol	0.3	0.4	1.2	1.1	0.6	0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.6	-0.1	-0.1	0.0
Back pain experienced in last month	0.2	0.3	0.7	0.8	-0.1	-0.7	0.3
Mineral and other dietary supplements	1.1	1.5	3.2	1.4	1.8	-0.3	-0.9
Breast cancer (self-reported)	1.5	1.8	2.5	1.1	1.2	-1.3	1.6
Asthma (self-reported)	3.6	7.2	10.7	-2.4	-1.8	3.3	-3.0
Osteoporosis (self-reported)	0.4	0.5	1.5	-0.1	-1.2	-0.2	0.5
Osteoarthritis (self-reported)	1.0	1.2	3.9	-2.0	-0.8	0.3	-0.5
Medication: Aspirin	3.1	4.1	7.9	-2.7	-2.8	1.1	0.3
Medication: Gliclazide	2.1	2.3	6.9	-0.7	-0.4	2.6	-1.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.6	0.2	0.8	0.1	-0.1
Smoking status: Current	0.2	0.3	0.6	-0.7	-0.5	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	1.5	0.6	-0.5	1.2
Whole body water mass	2.9	16.5	42.4	3.7	6.5	-1.8	-2.5
Leg predicted mass (right)	1.9	10.3	27.9	2.7	5.3	-0.9	-2.2
Arm fat mass (left)	0.3	1.2	3.5	0.5	1.9	0.2	-1.1
Number of self-reported non-cancer illnesses	2.6	4.5	8.1	-2.8	-2.4	1.8	-1.1
Average weekly champagne plus white wine intake	1.2	1.7	3.7	-0.2	-1.0	-1.4	1.9
Miserableness	0.7	1.3	4.0	0.8	2.0	0.3	-0.5
Guilty feelings	0.1	0.1	0.5	0.0	0.2	-0.7	0.2
Wears glasses or contact lenses	3.3	3.8	8.5	-1.1	-1.6	2.9	-1.6
Ever taken oral contraceptive pill	0.5	0.6	2.2	1.5	0.2	-0.3	0.1
Hearing aid user	0.6	0.6	1.3	1.1	0.9	0.0	-0.7
Mother’s age at death	0.6	0.7	1.2	1.1	1.0	-0.8	0.0
Financial situation satisfaction	0.6	0.7	1.9	1.4	1.0	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	2.6	3.0	8.5	1.3	2.9	-1.1	-0.7
Commuting to job workplace: Public transport	1.7	2.1	4.7	1.6	2.2	-1.0	-0.0
Eye problems/disorders: Glaucoma	1.3	1.5	3.5	-0.9	-1.3	0.3	1.9
Medication: Blood pressure	0.1	0.2	0.3	-0.4	-0.1	-0.5	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.0	0.7	0.3	-0.8	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.4	-0.2	-1.2	-0.7	1.0
High cholesterol (Self-reported)	0.3	0.6	1.3	0.9	-0.4	0.0	-1.1
Medication: Bendroflumethiazide	0.2	0.3	1.0	-1.0	0.4	0.1	0.1
Medication: Paracetamol	0.8	1.2	3.8	0.2	0.6	0.9	-1.9
Medication: Lisinopril	0.4	0.6	1.7	0.5	1.3	-0.3	-0.5
Medication: Atorvastatin	1.2	1.4	2.2	-1.3	-1.2	1.5	-0.6
Illnesses of father: High blood pressure	1.2	1.4	3.6	1.9	1.4	0.1	-0.4
Alcohol drinker status: Never	0.6	0.7	1.6	-1.3	-0.9	-0.3	0.2
Ever smoked	0.2	0.3	0.8	-0.9	-0.4	-0.3	0.2
Basal metabolic rate	2.6	14.5	37.3	3.5	6.1	-1.6	-2.4
Leg fat percentage (left)	0.1	0.2	0.4	0.6	0.3	-0.6	0.1
Arm fat-free mass (left)	2.6	13.2	33.9	3.4	5.8	-1.9	-2.0
Number of operations (self-reported)	0.3	0.4	1.6	-1.3	-0.1	0.3	-0.1
Average weekly beer plus cider intake	0.9	1.3	2.3	1.5	1.0	-1.1	1.0
Irritability	0.5	0.9	1.6	1.3	1.3	-0.5	-0.2
Risk taking	0.1	0.2	0.7	0.0	0.1	-0.9	-0.2
Ever had prostate specific antigen (PSA) test	2.9	3.4	5.9	-1.9	-1.6	2.4	-1.3
Fractured/broken bones in last 5 years	1.2	1.5	4.3	0.8	2.1	0.4	-1.1
Age started oral contraceptive pill	0.6	0.8	1.3	-1.0	-1.1	0.6	0.8
Diastolic blood pressure, automated reading	0.2	0.5	1.1	-0.5	-0.8	1.0	-0.3
Ever depressed for a whole week	3.5	4.3	8.9	-1.8	-0.4	3.0	-2.2
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.1	0.1	0.5	-0.3
Commuting to job workplace: Cycle	0.3	0.4	0.7	-0.6	-0.6	0.8	-0.3
Myopia	1.7	2.5	6.7	-1.2	-2.6	1.3	0.3
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.3	1.0	1.4	-1.5	0.4
Cholesterol lowering medication	0.3	0.5	1.3	-0.7	-1.2	0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	0.2	-0.5	-0.1	1.2
Pain experienced in last month	0.1	0.1	0.3	0.4	0.6	-0.2	0.1
Supplements: Calcium	1.5	1.6	3.6	-1.5	-1.9	0.9	0.4
Basal cell carcinoma (self-reported)	2.3	2.8	4.1	2.0	0.7	-1.9	1.8
Heart attack/myocardial infarction (self-reported)	1.7	2.1	5.1	-1.8	-2.3	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.4	-0.8	0.2	1.0
Heart disease (siblings)	0.3	0.3	0.8	-0.9	-0.4	0.1	-0.6
Alcohol drinker status: Previous	0.5	0.6	2.0	1.4	0.4	0.1	-0.3
Pack years of smoking	0.1	0.1	0.3	0.4	0.5	0.2	0.1
Impedance of whole body	0.3	1.4	4.3	0.1	-2.1	-0.8	0.8
Leg fat mass (left)	0.8	3.0	6.9	1.9	2.6	-1.1	-0.5
Arm predicted mass (left)	2.7	13.6	34.2	3.4	5.8	-1.5	-2.5