Hub : Genes

KCNJ2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.022	0.0350	0.001	0.006	-0.002	0.009	-0.002	2.6e-01	0.056	0.87000	0.024	0.58000
2	GTEx	Colon Transverse	0.1230	0.050	0.0065	0.061	NA	0.072	NA	0.040	7.3e-04	NA	0.00025	NA	0.00560
3	GTEx	Muscle Skeletal	0.0753	0.031	0.0011	0.039	NA	0.010	NA	0.040	9.8e-05	NA	0.03500	NA	0.00008

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.4	2.2	3.7	-1.1	-1.9	1.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.3	0.0	-0.2
Depressed Affect (Nagel 2018)	0.6	1.4	3.5	-1.9	0.6	-0.5
Depression (Nagel 2018)	0.1	0.2	0.3	-0.3	0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.4	1.0	0.7	1.5
Neuroticism (Nagel 2018)	0.3	0.8	2.0	-1.4	0.6	0.1
Schizophrenia (2018)	1.0	2.0	2.6	1.3	1.6	-1.4
Schizophrenia vs Biploar Disorder	3.8	5.0	10.7	-0.1	3.3	-2.1
Worry (Nagel 2018)	0.3	0.7	1.7	-0.5	1.3	-0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-0.8	-0.1	-1.2
Alzheimer’s Disease (in father)	1.5	1.6	3.8	-0.5	-2.0	0.9
Alzheimer’s Disease (including proxy)	0.3	0.5	1.4	-0.2	-1.2	-0.2
Crohns Disease (2017)	1.1	2.5	4.2	-1.7	0.6	-2.1
Irritable Bowel Disease (IBD)	1.2	2.9	5.3	-2.3	0.6	-1.8
Ulcerative Colitis (UC)	0.9	1.8	5.0	-2.2	-0.1	-0.6
Major Depression (MDD)	1.1	1.3	3.0	-0.2	1.7	0.9
Reaction Time	0.5	0.9	1.6	0.9	0.5	1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.1	0.6	0.6	2.0
Breast Cancer	0.2	0.5	0.8	-0.9	0.8	-0.1
Ovarian Cancer	1.2	1.6	4.2	2.0	-0.3	-0.7
Prostate Cancer	0.4	0.5	1.1	-0.7	1.0	0.3
Age at First Birth	1.3	1.8	3.1	1.8	-1.6	0.1
Bipolar Disorder (2011)	0.4	0.3	1.0	-1.0	-0.1	0.2
Body Mass Index (BMI) (2010)	0.6	0.9	1.5	1.2	0.6	-0.9
Coronary Artery Disease (CAD)	3.3	4.0	7.6	1.5	-1.5	2.8
Crohns Disease (2012)	2.2	3.5	6.8	-1.9	0.3	-2.6
Mean Putamen Volume	0.7	0.8	2.2	-0.5	0.4	-1.5
Fasting Glucose	4.2	5.0	7.8	2.8	-2.2	1.4
HbA1C	1.8	2.0	4.2	1.2	-0.7	2.1
HDL Cholesterol	0.2	0.3	0.5	-0.1	-0.7	-0.6
LDL Cholesterol	1.3	2.0	3.8	-1.3	-2.0	0.8
Lupus	1.0	1.5	2.6	1.4	-0.2	1.6
Neuroticism (2016)	0.2	0.3	0.6	-0.8	0.2	-0.4
Primary Biliary Cirrhosis	1.7	2.4	5.5	0.0	2.4	-1.3
Rheumatoid Arthritis	0.3	0.4	1.0	-0.4	-0.2	-1.0
Schizophrenia (2014)	0.6	1.4	2.7	0.0	1.2	-1.7
Triglycerides	0.4	0.6	1.2	-0.2	-1.1	0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.3	0.4	-0.7	-1.1
Ulcerative Colitis	3.5	5.0	9.3	-3.0	-2.3	-0.6
Blood Eosinophil Count	2.5	19.5	52.6	-2.0	1.4	-7.2
Blood Platelet Count	0.1	0.9	1.8	-1.3	-0.9	-0.3
Blood Red Count	0.0	0.3	0.5	-0.7	-0.7	0.2
Blood White Count	0.6	4.7	10.6	1.8	-3.2	0.5
Heel T-Score	0.6	4.5	10.8	-3.3	-0.5	1.5
BMI	1.2	6.7	19.0	-0.2	1.0	-4.4
Height	0.7	13.6	25.9	-1.8	3.5	-5.1
Waist Hip Ratio (WHR)	10.5	47.3	79.6	-1.1	-8.9	7.8
Systolic Blood Pressure	0.3	1.5	3.1	-1.8	1.2	0.1
Smoking Status	0.2	0.4	1.0	-0.1	1.0	-0.5
Allergy or Eczema	0.3	0.7	1.3	-0.9	0.1	1.1
Cardiovascular Disease	0.3	1.1	3.2	-1.8	-0.1	0.3
Hypothyroidism (self reported)	0.8	1.8	2.7	0.9	1.4	-1.6
Respiratory disease	0.2	0.6	1.0	-0.8	-0.2	1.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.4	2.1	0.2	0.2
Lung FEV1/FVC ratio	0.4	1.8	2.8	-1.6	-0.3	1.7
Lung FVC	0.1	0.6	1.2	-0.7	-1.1	0.0
Neuroticism	1.3	3.0	5.7	-2.4	1.8	0.2
Chronotype (morning person)	0.3	0.6	1.6	1.3	0.4	-0.1
Hair Pigment	0.0	1.2	3.0	-1.7	-0.9	0.2
Tanning	0.1	1.2	3.4	-0.3	1.8	0.0
Hand grip strength (left)	0.6	1.6	2.5	-1.1	-1.1	-1.6
Number of treatments/medications taken	0.4	0.8	1.3	0.9	-0.3	-1.1
Average weekly spirits intake	2.4	3.0	7.3	0.9	-2.7	-0.9
Sensitivity / hurt feelings	0.2	0.3	1.0	0.1	-0.1	1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.4	0.7	0.6
Hearing difficulty/problems: Yes	1.2	1.9	4.0	1.1	2.0	0.7
Relative age of first facial hair	0.9	1.9	3.4	-1.5	-1.9	-0.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.7	1.6	-0.6	1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.5	-1.6	-0.0	0.3
Ever had hysterectomy (womb removed)	1.4	1.5	2.9	-1.7	0.3	1.3
Systolic blood pressure, automated reading	0.2	0.6	1.0	-0.6	0.7	-1.0
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	8.1	2.9	-0.0	-0.9
Angina	0.1	0.2	0.2	-0.4	-0.4	0.4
Medication for hormone replacement therapy	0.6	0.7	1.7	-0.6	1.3	0.1
Vitamin and mineral supplements	0.4	0.5	1.0	0.5	0.5	-1.0
Supplements: Zinc	0.0	0.0	0.0	-0.0	0.2	0.1
Medication: Co-codamol	1.0	1.2	1.7	-0.4	-1.3	1.3
Medication: Metformin	0.6	0.9	2.3	1.5	-0.2	-0.5
Diabetes (father)	1.0	1.2	2.9	1.7	-0.6	-0.6
Diabetes (mother)	1.0	1.2	2.1	0.9	-1.4	0.9
Severe depression (siblings)	0.1	0.1	0.2	-0.1	0.1	0.4
Pack years adult smoking proportion	1.1	1.6	2.0	-1.3	-1.0	-1.4
Impedance of leg (right)	1.0	4.9	8.0	-0.2	-2.8	2.6
Leg fat-free mass (left)	1.6	8.7	15.7	-0.3	3.2	-4.0
Trunk fat percentage	0.6	2.2	6.2	0.7	0.0	-2.5
Hand grip strength (right)	0.4	1.1	2.9	-0.5	0.0	-1.7
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.2	0.3	0.4
Current tobacco smoking	0.3	0.5	1.1	0.3	-0.4	-1.1
Average weekly fortified wine intake	0.2	0.3	0.4	-0.7	-0.6	0.1
Maternal smoking around birth	0.4	0.6	1.1	-0.9	-1.0	-0.3
Fed-up feelings	0.9	1.7	3.6	-1.9	0.6	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.4	0.2	-0.5
Relative age voice broke	0.9	1.4	3.8	-2.0	-0.1	-0.7
Taking other prescription medications	0.1	0.1	0.2	0.5	-0.1	-0.2
Age when periods started (menarche)	0.4	0.9	1.9	0.7	-1.4	-0.6
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	4.5	-0.5	-1.7	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.9	-0.9	-0.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.9	-0.1	0.2	-1.4
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.2	0.9	-0.4
Serious illness, injury or assault to yourself	1.5	1.8	3.3	0.1	1.8	-1.5
High blood pressure	0.2	0.6	0.9	-0.9	-0.9	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.6	-1.6	0.7	1.0
Multivitamins +/- minerals	0.0	0.0	0.1	-0.3	0.2	0.1
Stomach or abdominal pain in last month	0.8	1.0	2.1	0.7	1.5	-0.5
Supplements: Glucosamine	2.1	2.7	5.1	-1.7	-2.3	0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.7	-1.1	-0.4	1.6
Medication: Atenolol	1.0	1.3	3.0	-1.7	-0.4	0.9
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.1	0.1	-1.2
Sitting height	0.5	3.5	6.6	0.9	2.6	-1.8
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.4	-0.6	0.1
High blood pressure (mother)	1.0	1.4	2.6	1.6	0.5	1.1
Body mass index (BMI)	1.1	4.5	12.7	0.3	0.9	-3.6
Impedance of leg (left)	1.2	5.8	8.6	-1.3	-2.9	2.7
Leg predicted mass (left)	1.7	9.1	16.6	-0.4	3.2	-4.1
Trunk fat mass	0.9	4.0	11.4	0.5	0.7	-3.4
Waist circumference	0.4	1.4	3.8	-0.5	-0.5	-1.9
Number of incorrect matches in round	0.6	1.0	2.4	-1.5	-0.8	0.2
Past tobacco smoking	0.4	0.7	1.8	-0.3	-1.3	-0.4
Alcohol usually taken with meals	1.5	2.5	4.0	-1.6	-0.9	2.0
Nervous feelings	0.3	0.6	0.7	0.9	0.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.8	-1.7	-1.1	1.3
Hearing difficulty/problems with background noise	1.6	2.5	5.1	-0.7	2.2	-1.4
Hair/balding pattern: Pattern 2	0.6	0.7	1.4	-1.2	-0.4	-0.8
Had menopause	0.5	0.7	1.7	-0.5	-1.3	0.3
Had other major operations	0.5	0.7	1.4	0.5	-1.2	-0.5
Forced vital capacity (FVC)	0.4	1.4	3.3	-0.7	1.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	-1.1	-0.5	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.1	0.6	-1.1
Qualifications: None of the above	0.1	0.2	0.6	-0.1	-0.8	-0.3
Financial difficulties in last 2 years	0.6	0.7	1.4	-0.2	1.2	-0.9
Mouth/teeth dental problems	1.2	1.9	3.8	0.6	1.9	-1.3
Heart attack	0.7	0.9	1.6	0.1	-1.1	1.3
Allergy	0.5	1.2	2.4	1.6	-0.3	-1.0
Pain all over the body in last month	0.4	0.5	1.1	1.1	-0.5	0.2
Diabetes (self-reported)	1.0	1.6	4.7	2.2	-0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.3	0.1	1.5	0.0
Medication: Ramipril	1.4	1.8	3.0	0.8	-1.7	1.3
Medication: Simvastatin	0.4	0.5	1.3	0.1	-0.6	1.1
Fluid intelligence score	1.4	2.8	5.7	1.5	0.7	2.4
Illnesses of siblings	0.0	0.0	0.1	0.2	-0.2	-0.2
Neuroticism score	0.5	1.0	1.6	-1.2	1.3	0.2
Weight	1.6	8.0	19.4	-0.3	2.1	-4.4
Impedance of arm (right)	0.2	1.0	3.0	-0.3	0.3	1.7
Arm fat percentage (right)	0.8	3.3	9.8	0.3	0.4	-3.1
Trunk fat-free mass	1.6	8.9	16.4	-1.3	2.9	-4.0
Hip circumference	5.0	21.5	43.1	-0.6	4.6	-6.6
Time employed in main current job	3.0	3.4	5.6	-0.3	2.4	-2.2
Alcohol intake versus 10 years previously	0.5	0.8	1.5	0.8	-1.2	-0.5
Father’s age at death	0.5	0.6	1.7	1.3	-0.3	0.3
Worrier / anxious feelings	0.1	0.3	0.7	0.1	0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.3	-0.7	0.3
Falls in the last year	0.3	0.4	1.1	0.0	1.0	0.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.8	0.9	-1.7	-0.1
Number of live births	0.0	0.1	0.2	0.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.1	-1.8	1.5	-0.3
Pulse rate	2.4	4.0	8.2	0.8	-2.9	1.8
Happiness	0.7	0.8	1.7	-0.6	1.3	0.6
Noisy workplace	0.2	0.2	0.4	0.4	0.3	0.7
Qualifications: A levels/AS levels or equivalent	1.7	3.8	11.3	-0.2	0.4	3.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.6	-1.6	0.3	-0.5
Mouth/teeth dental problems: Dentures	2.5	4.3	9.7	0.2	-3.1	1.8
Asthma	0.3	0.5	0.7	-0.6	0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	0.9	-1.1	0.6
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.6	-0.1	-0.1
Depression (self-reported)	0.2	0.3	0.7	0.2	0.8	0.2
Medication: Lansoprazole	0.7	0.9	1.8	1.3	0.8	0.4
Prospective memory result	1.3	1.6	3.7	1.0	-1.9	0.0
Lung cancer (father)	1.4	1.6	4.3	-2.1	0.5	0.5
Illnesses of mother	0.3	0.4	0.6	-0.8	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.7	-1.6	1.2	-1.1
Pulse wave Arterial Stiffness index	4.1	4.8	11.4	-1.0	-3.4	1.5
Impedance of arm (left)	0.4	1.8	4.4	0.9	0.1	2.1
Arm fat mass (right)	1.2	4.9	13.7	0.3	0.9	-3.7
Trunk predicted mass	1.6	9.1	16.3	-1.4	3.0	-4.0
Standing height	0.6	5.6	9.5	-1.2	3.1	-2.4
Length of working week for main job	1.0	1.1	2.5	1.6	0.4	-0.8
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.5	-0.1	-0.6
Breastfed as a baby	1.1	1.4	2.2	-1.5	0.3	1.3
Tense / ‘highly strung’	0.4	0.6	1.1	-1.0	-0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	2.8	1.7	1.0	1.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.3	-0.3	0.7
Birth weight of first child	0.5	0.9	2.6	1.6	0.5	-0.0
Peak expiratory flow (PEF)	0.2	0.5	1.2	-0.6	1.1	-0.0
Pulse wave reflection index	0.5	0.7	1.4	-0.7	-1.2	0.4
Ever highly irritable/argumentative for 2 days	2.9	3.4	9.0	-0.6	-1.0	3.0
Loud music exposure frequency	0.2	0.3	0.6	0.8	-0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.5	-0.8	0.9	2.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.5	-0.5	-0.0
Blood clot in the leg (DVT)	0.4	0.5	0.7	-0.6	-0.6	-0.8
Medication: Paracetamol	0.3	0.4	0.9	0.6	-0.9	0.2
Headache pain in last month	0.5	0.9	1.3	1.1	0.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.9	-0.0	0.6
Glaucoma (self-reported)	0.0	0.0	0.0	-0.1	0.0	0.1
Gout (self-reported)	0.7	0.9	2.4	-0.7	0.2	-1.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.6	1.6	1.0	-0.7
Medication: Amlodipine	0.4	0.6	0.8	-0.9	-0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.8	-0.3	-0.3	1.7
Birth weight	1.5	3.2	4.2	-1.4	2.0	-1.8
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.2	-0.1	-1.8	0.7
High blood pressure (siblings)	0.4	0.6	1.5	0.6	-0.0	1.2
Forced vital capacity (FVC), Best measure	0.6	2.1	2.7	-1.1	1.6	-1.5
Body fat percentage	0.6	2.2	6.2	0.6	-0.3	-2.5
Leg fat percentage (right)	0.5	1.9	5.4	0.4	-0.4	-2.3
Arm fat-free mass (right)	1.0	5.3	11.9	-0.5	1.9	-3.5
Exposure to tobacco smoke outside home	0.2	0.3	0.5	0.0	-0.7	0.6
Comparative body size at age 10	0.6	1.7	2.5	1.6	1.6	-0.2
Number of full brothers	0.8	1.0	1.6	-1.1	-0.5	1.3
Worry too long after embarrassment	1.4	2.4	2.6	-1.4	1.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.0	1.7	0.2	0.6
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	-0.7	0.0	-1.2
Number of children fathered	0.5	0.5	1.3	0.1	0.5	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.0	-0.9	0.7	1.0
Age at first live birth	1.6	2.8	4.0	-1.7	-2.0	1.3
Pulse wave peak to peak time	5.0	5.9	13.1	0.9	3.6	-2.0
Health satisfaction	0.0	0.1	0.1	0.2	-0.4	0.1
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.3	0.1	-0.4
Qualifications: College or University degree	0.6	2.0	5.5	-0.3	0.6	2.4
Eye problems/disorders: None of the above	0.6	0.7	1.9	-1.4	-0.3	0.3
Mouth/teeth dental problems: Loose teeth	1.9	2.3	2.9	-1.7	-1.7	1.1
Emphysema/chronic bronchitis	2.8	3.2	7.1	0.1	-2.7	1.6
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.1	-0.4	0.0
Neck or shoulder pain in last month	2.6	3.7	4.9	1.4	-2.1	-2.2
Medication: Blood pressure	0.1	0.2	0.5	-0.3	-0.3	0.7
Angina (self-reported)	0.2	0.2	0.2	-0.4	-0.4	0.5
Migraine (self-reported)	1.0	1.2	1.5	1.2	1.1	1.1
Medication: Ibuprofen	1.3	1.5	2.6	1.3	-1.6	0.5
Medication: Allopurinol	0.3	0.4	1.0	-0.1	0.4	-1.0
Medication: Omeprazole	0.6	0.8	1.5	-0.6	0.7	-1.2
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.4	-0.6	1.3
Mean time to correctly identify matches	0.4	0.8	1.9	0.7	-0.1	1.4
Heart disease (mother)	0.7	0.9	2.3	1.5	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-1.4	0.6	-0.8
Whole body fat mass	0.8	3.5	10.2	0.3	0.3	-3.2
Leg fat mass (right)	1.0	3.7	10.9	0.2	0.4	-3.3
Arm predicted mass (right)	1.0	5.1	11.0	-0.4	2.1	-3.3
Pulse rate, automated reading	1.0	3.2	4.2	2.0	-2.0	1.2
Alcohol intake frequency.	0.0	0.1	0.2	-0.3	-0.1	-0.4
Comparative height size at age 10	0.6	3.2	6.1	1.4	2.5	-1.2
Number of full sisters	0.6	0.7	1.0	-1.0	-1.0	0.3
Suffer from ‘nerves’	0.9	1.5	3.4	-1.0	1.8	-0.4
Overall health rating	1.2	2.5	7.5	-0.1	-0.3	-2.7
Chest pain or discomfort	1.0	1.5	3.9	-0.8	0.1	-2.0
Had major operations	1.5	1.7	2.0	1.2	-1.3	1.4
Age at last live birth	0.8	1.1	2.7	-0.5	-0.6	1.6
Family relationship satisfaction	2.3	2.8	4.5	-0.5	2.1	-1.9
Leg pain on walking	1.1	1.4	3.7	-0.2	-1.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	0.1	-0.3	-1.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.2	1.3	-1.5	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	1.2	-0.9	0.2
Medication: Aspirin	0.1	0.2	0.3	-0.4	0.6	0.1
Supplements: Vitamin C	1.8	2.1	3.9	-1.2	-1.0	2.0
Knee pain experienced in last month	1.1	1.7	4.4	-2.1	-0.5	-0.7
Hypertension (Self-reported)	0.0	0.1	0.2	-0.5	-0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.3	-0.9	-0.1
Illnesses of father: Heart disease	0.8	1.0	2.2	-1.5	0.1	-1.0
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.8	0.2	-0.3
Smoking status: Previous	0.6	1.0	2.9	0.0	1.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	6.2	0.1	2.5	-1.1
Whole body fat-free mass	1.6	9.2	17.3	-0.9	3.0	-4.2
Leg fat-free mass (right)	1.7	9.2	15.8	-0.6	3.4	-4.0
Arm fat percentage (left)	0.8	3.2	8.7	0.9	0.4	-3.0
Average weekly red wine intake	2.3	3.3	8.7	-2.9	-1.1	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.6	-0.5	-0.1
Mood swings	0.2	0.4	0.8	-0.7	-0.1	0.9
Loneliness, isolation	1.1	1.5	3.5	-1.9	0.7	-0.7
Long-standing illness, disability or infirmity	1.0	1.5	2.9	1.7	-1.1	-0.8
Ever had bowel cancer screening	1.1	1.3	2.8	1.7	-1.0	0.3
Diabetes diagnosed by doctor	0.7	1.2	3.4	1.8	-0.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.9	-0.4	-0.8	2.0
Friendships satisfaction	1.3	1.6	2.6	-1.0	1.1	-1.6
Qualifications: nursing, teaching	0.7	1.1	1.6	1.2	-0.9	1.0
Commuting to job workplace: Walk	0.9	1.0	1.5	-1.2	-0.1	1.2
Eye problems/disorders: Cataract	1.4	1.6	2.7	1.7	1.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.2	0.7	-0.1
Medication for cholesterol	0.4	0.6	1.8	0.3	0.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.7	-0.3	1.3	1.2
Back pain experienced in last month	2.6	3.8	11.1	-0.6	-0.2	-3.3
Mineral and other dietary supplements	0.9	1.2	3.1	0.7	1.8	0.0
Breast cancer (self-reported)	0.8	0.9	2.2	0.5	0.5	-1.5
Asthma (self-reported)	0.2	0.4	0.9	-0.4	0.9	0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.4	0.2	-0.4
Osteoarthritis (self-reported)	1.8	2.3	4.0	-2.0	-1.7	0.1
Medication: Aspirin	0.1	0.1	0.2	0.4	0.3	0.1
Medication: Gliclazide	2.8	3.2	9.2	0.6	-0.2	-3.0
Illnesses of father: None of the above (group 1)	1.0	1.2	3.1	0.1	0.7	1.8
Smoking status: Current	0.2	0.3	0.6	0.3	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.5	-0.3	1.9	0.1
Whole body water mass	1.6	9.0	16.8	-1.0	3.0	-4.1
Leg predicted mass (right)	1.8	9.4	16.2	-0.7	3.4	-4.0
Arm fat mass (left)	1.2	5.1	13.8	0.4	1.1	-3.7
Number of self-reported non-cancer illnesses	0.6	1.0	1.1	1.1	-0.9	-1.0
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.2	-0.7	0.6
Miserableness	0.3	0.5	1.5	-0.3	1.2	-0.2
Guilty feelings	0.9	1.4	2.8	-1.7	0.2	1.1
Wears glasses or contact lenses	0.7	0.8	0.9	0.8	1.0	-1.0
Ever taken oral contraceptive pill	0.5	0.5	0.8	0.2	-0.8	0.9
Hearing aid user	0.5	0.5	1.1	1.0	-0.2	-0.7
Mother’s age at death	0.4	0.5	0.9	-0.2	-1.0	0.7
Financial situation satisfaction	0.5	0.6	1.7	0.3	1.3	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.8	0.4	-1.1
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.1	-0.2	-0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.4	-0.6	0.5
Medication: Blood pressure	0.0	0.1	0.1	-0.3	0.2	0.4
Pain type(s) experienced in last month: Hip pain	2.5	3.2	7.8	1.3	-2.8	0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.2	-0.5	-1.1	0.9
High cholesterol (Self-reported)	1.0	1.7	5.2	-2.3	-0.1	-0.1
Medication: Bendroflumethiazide	0.4	0.6	1.3	1.1	0.6	-0.2
Medication: Paracetamol	0.3	0.5	0.8	0.6	-0.5	-0.9
Medication: Lisinopril	0.6	0.8	1.1	-1.0	0.6	-1.0
Medication: Atorvastatin	0.1	0.1	0.3	-0.3	0.1	-0.5
Illnesses of father: High blood pressure	0.5	0.6	1.1	0.3	1.0	-0.8
Alcohol drinker status: Never	0.7	0.8	1.3	1.1	-1.0	0.3
Ever smoked	1.3	2.3	6.5	0.6	0.4	2.5
Basal metabolic rate	1.7	9.5	19.7	-0.8	2.9	-4.4
Leg fat percentage (left)	0.5	1.9	5.6	-0.1	-0.3	-2.4
Arm fat-free mass (left)	1.5	7.5	15.1	-1.0	2.6	-3.9
Number of operations (self-reported)	3.8	5.7	7.7	2.4	-1.8	2.8
Average weekly beer plus cider intake	3.1	4.5	13.2	0.1	0.7	-3.6
Irritability	0.2	0.3	0.6	-0.8	-0.2	0.6
Risk taking	0.5	0.7	1.4	-0.1	-0.8	1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.1	0.5	0.8
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-1.0	-0.5	-0.2
Age started oral contraceptive pill	0.7	0.9	1.8	-1.4	-0.5	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	1.4	-1.2	-0.3	0.3
Ever depressed for a whole week	1.2	1.4	3.3	0.9	1.8	-0.5
Unable to work because of sickness or disability	0.4	0.5	1.1	0.6	-0.2	-1.1
Commuting to job workplace: Cycle	1.6	1.9	3.6	-1.2	-1.9	0.8
Myopia	2.3	3.3	6.6	0.8	2.6	-1.6
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.2	1.1	1.0	0.0
Cholesterol lowering medication	0.5	0.8	1.2	0.2	-1.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.2	-0.1	-0.8
Pain experienced in last month	2.6	4.4	10.0	-1.7	0.3	3.2
Supplements: Calcium	1.6	1.8	2.8	-0.3	1.7	1.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	0.2	-0.1	1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.0	0.3	-1.1	1.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-0.6	-0.5	-0.9
Heart disease (siblings)	1.0	1.3	3.6	0.1	-1.9	0.4
Alcohol drinker status: Previous	1.4	1.5	3.9	-2.0	-0.6	0.6
Pack years of smoking	1.2	1.7	2.4	-1.5	-1.2	-1.2
Impedance of whole body	0.5	2.7	6.1	0.0	-1.4	2.5
Leg fat mass (left)	1.0	3.9	11.4	-0.2	0.3	-3.4
Arm predicted mass (left)	1.5	7.6	15.5	-1.1	2.5	-3.9