Hub : Genes

KCNK17

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.1371 0.0325 2.2e-09 0.075 0.078 0.087 NA 0.077 2.7e-11 1.1e-11 5.0e-13 NA 1.1e-11
2 TCGA Cervical Squamous Cell Carcinoma 0.2210 0.0880 3.8e-03 0.001 0.029 0.066 NA 0.016 2.9e-01 1.3e-02 3.6e-04 NA 5.3e-02
3 TCGA Head and Neck Squamous Cell Carcinoma 0.2059 0.0555 3.2e-06 0.005 0.035 0.013 NA 0.000 9.1e-02 8.2e-05 1.3e-02 NA 3.1e-01
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0647 0.0288 7.3e-04 0.044 0.024 0.038 NA 0.038 8.6e-06 9.3e-04 3.7e-05 NA 4.0e-05
5 TCGA Brain Lower Grade Glioma 0.0470 0.0262 5.7e-03 -0.001 0.005 0.008 NA 0.001 4.3e-01 8.4e-02 4.0e-02 NA 2.2e-01
6 TCGA Lung Adenocarcinoma 0.0432 0.0207 3.3e-03 0.009 0.005 0.000 NA 0.001 2.8e-02 6.6e-02 3.1e-01 NA 2.3e-01
7 TCGA Lung Squamous Cell Carcinoma 0.0526 0.0269 7.3e-03 -0.002 0.020 0.007 NA 0.000 5.8e-01 2.3e-03 4.6e-02 NA 3.4e-01
8 TCGA Ovarian Serous Cystadenocarcinoma 0.2480 0.0660 2.1e-10 0.164 0.154 0.181 NA 0.192 3.0e-11 1.3e-10 2.7e-12 NA 5.0e-13
9 TCGA Pancreatic Adenocarcinoma 0.1660 0.0680 1.8e-03 0.118 0.070 0.048 NA 0.056 1.2e-05 7.1e-04 4.3e-03 NA 2.2e-03
10 TCGA Pheochromocytoma and Paraganglioma 0.0930 0.0460 8.2e-03 0.057 0.054 0.017 NA 0.053 2.7e-03 3.5e-03 6.6e-02 NA 3.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.6 1.0 3.4 1.8 0.6 1.3 0.9 0.3 0.2 0.9 -0.5 -1.1 1.1
Bipolar Disorder or Schizophrenia 0.2 0.4 0.9 -0.3 0.9 0.9 -0.9 0.3 0.5 0.3 0.9 -0.2 0.1
Depressed Affect (Nagel 2018) 1.1 2.3 5.8 1.8 -1.8 -0.9 2.4 -1.6 -1.2 -1.3 -1.6 -1.2 0.4
Depression (Nagel 2018) 0.5 0.7 2.6 1.6 0.9 0.6 1.3 -0.4 -0.0 1.2 -0.2 -0.6 0.3
Intelligence (Savage-Jansen 2018) 0.4 1.3 4.2 -1.5 0.2 -0.1 -0.7 0.2 2.1 0.1 1.8 0.9 -1.2
Neuroticism (Nagel 2018) 0.9 2.2 4.8 1.0 -2.2 -1.4 1.8 -2.1 -1.2 -0.9 -1.6 -1.1 0.4
Schizophrenia (2018) 0.5 1.1 3.5 -1.9 0.4 -0.0 -1.9 0.0 0.6 -0.4 1.6 0.6 -0.8
Schizophrenia vs Biploar Disorder 0.6 0.8 1.8 -0.3 -1.0 -0.3 -0.6 -0.8 1.3 -1.1 0.6 0.7 -1.2
Worry (Nagel 2018) 0.5 1.1 3.1 0.3 -1.8 -1.4 1.4 -1.0 -0.3 -0.7 -1.3 -1.0 0.3
Alzheimer’s Disease (in mother) 2.0 2.3 6.2 -1.2 0.4 1.7 -2.3 -0.7 1.1 1.1 2.5 1.8 -1.1
Alzheimer’s Disease (in father) 0.6 0.6 3.1 -1.8 0.8 0.3 -0.7 -0.9 -0.7 0.3 0.5 -0.2 0.3
Alzheimer’s Disease (including proxy) 1.1 1.6 4.9 -1.9 0.1 1.2 -2.2 -1.0 0.5 0.3 1.6 1.2 -0.8
Crohns Disease (2017) 0.3 0.7 2.6 -0.1 0.1 -1.0 -0.5 -0.5 1.6 -0.5 0.9 0.3 -1.2
Irritable Bowel Disease (IBD) 0.3 0.8 4.2 0.4 -0.8 -2.1 0.4 -1.0 0.1 -0.9 -0.3 -0.6 -0.6
Ulcerative Colitis (UC) 0.8 1.5 4.0 0.6 -1.0 -2.0 1.1 -1.1 -1.5 -0.6 -1.1 -1.5 0.5
Major Depression (MDD) 1.5 1.9 5.6 -0.1 -1.6 -1.6 -0.1 0.3 -1.1 -2.4 0.3 -1.1 -2.3
Reaction Time 1.0 1.9 5.7 1.5 0.1 -0.1 1.3 -1.4 -2.4 1.2 -1.4 -1.1 1.7
Verbal and Numeric Reasoning (VNR) 0.4 1.0 4.5 0.2 1.5 1.1 0.2 0.4 2.1 1.0 0.4 0.0 0.2
Breast Cancer 0.1 0.3 1.0 0.3 -0.6 -0.3 0.8 0.3 -0.6 -0.4 -1.0 -0.5 -0.2
Ovarian Cancer 0.3 0.4 2.3 0.2 0.7 -0.2 -0.0 -0.1 1.5 0.7 -0.3 -0.1 0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.2 0.7 0.0 0.1 0.1 -0.5 -0.7 0.6 -0.8 0.2 0.4 0.0
Bipolar Disorder (2011) 0.3 0.3 1.2 0.6 -1.1 -0.6 0.2 -0.3 0.5 0.5 -0.3 -0.4 0.2
Body Mass Index (BMI) (2010) 1.3 1.8 5.6 2.1 2.1 0.7 0.3 0.3 -2.4 1.5 0.1 -0.2 0.9
Coronary Artery Disease (CAD) 0.6 0.7 2.2 -0.4 -0.9 0.8 -0.3 0.6 1.5 1.1 0.7 0.6 0.6
Crohns Disease (2012) 0.6 1.0 3.0 -0.9 -0.4 -1.3 -0.8 -0.3 1.3 -1.7 0.4 -0.1 -1.2
Mean Putamen Volume 1.8 2.0 4.8 -1.1 -0.6 0.6 -1.3 0.4 2.0 1.0 2.1 2.2 -1.5
Fasting Glucose 0.7 0.8 4.1 -1.3 -2.0 -1.0 0.5 0.2 0.1 -0.1 -0.6 0.8 0.4
HbA1C 0.6 0.7 2.2 0.4 -0.7 -0.3 1.2 -0.4 -1.2 0.5 -1.5 -0.3 0.9
HDL Cholesterol 0.7 1.2 4.0 0.3 -2.0 1.9 -0.1 -0.1 1.8 -0.6 0.5 0.3 -0.6
LDL Cholesterol 0.6 1.0 2.9 -0.8 0.4 -0.3 -1.2 1.1 1.7 1.1 0.8 0.9 -0.5
Lupus 1.6 2.4 14.1 -0.3 -3.8 -1.9 -0.0 -0.8 -0.9 -1.7 -0.1 0.9 -1.2
Neuroticism (2016) 0.5 0.7 2.9 0.3 0.0 -0.4 1.0 0.0 -0.6 -0.7 -1.4 -1.7 0.6
Primary Biliary Cirrhosis 1.2 1.8 7.2 -2.7 0.7 0.2 -1.3 0.8 0.9 -0.6 1.5 1.6 -1.2
Rheumatoid Arthritis 0.7 0.9 5.7 -2.4 0.6 0.8 -1.1 -0.3 0.5 -0.1 1.0 0.2 -0.3
Schizophrenia (2014) 0.3 0.6 1.8 -1.3 0.3 0.4 -1.3 -0.7 0.5 -0.0 1.1 0.7 -0.4
Triglycerides 0.7 1.1 2.5 -1.6 0.9 -1.6 -0.7 0.0 -1.1 1.4 0.7 1.1 0.2
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.7 -0.9 -1.1 -1.6 -0.0 1.1 -0.9 -0.8 -0.4 0.2 -0.8
Ulcerative Colitis 0.8 1.1 5.3 -0.4 -2.3 -1.5 -0.2 -0.9 -0.6 -1.3 -0.6 -0.4 -0.0
Blood Eosinophil Count 0.1 0.7 3.3 -0.0 -0.5 0.8 1.0 -1.8 -0.6 1.0 0.4 -0.2 0.5
Blood Platelet Count 0.4 4.8 17.8 -4.2 -1.3 0.3 -2.0 0.2 2.9 -0.0 2.4 2.6 -1.8
Blood Red Count 0.1 1.4 2.7 1.4 0.7 1.0 0.2 1.5 1.6 -0.9 1.6 0.3 -1.4
Blood White Count 0.3 1.9 5.9 -0.3 1.5 1.2 -0.1 2.4 1.8 -0.6 1.5 0.3 -1.8
Heel T-Score 0.4 3.4 12.7 3.6 -0.6 2.1 2.5 -0.8 1.0 0.5 -1.5 -1.9 1.6
BMI 0.6 3.8 13.0 3.3 1.8 -0.9 1.5 -0.3 -3.6 1.0 -0.9 -2.1 0.9
Height 0.2 3.6 9.7 -1.2 0.1 -2.5 3.1 -2.5 -1.8 -0.6 -1.6 0.4 2.6
Waist Hip Ratio (WHR) 1.2 5.3 11.0 -3.0 -3.3 -1.7 -1.9 0.9 2.6 -1.3 2.2 1.1 -3.3
Systolic Blood Pressure 0.7 3.4 10.3 -2.1 1.7 1.7 0.3 1.6 3.2 2.9 0.4 1.2 1.3
Smoking Status 0.2 0.5 1.6 1.0 0.3 1.3 1.2 -0.0 0.1 -0.5 0.2 -0.8 0.1
Allergy or Eczema 0.2 0.6 1.9 -0.2 -1.1 -1.4 0.3 0.3 -0.5 -1.2 -0.2 -0.3 -1.0
Cardiovascular Disease 2.1 6.8 11.4 -3.3 1.7 0.0 -2.6 2.7 2.5 3.3 3.1 3.4 -1.7
Hypothyroidism (self reported) 0.7 1.7 4.7 -1.6 -0.1 -0.6 -2.2 -1.2 0.0 0.9 1.5 2.1 -0.6
Respiratory disease 0.4 0.8 5.0 0.0 -1.1 -0.7 -0.3 -0.7 -2.2 -0.3 -0.1 -0.7 -0.4
Type 2 Diabetes (T2D) (2018) 2.0 3.8 22.3 -2.5 -4.7 -2.1 -0.1 0.3 -0.0 -1.2 0.1 1.5 -1.2
Lung FEV1/FVC ratio 0.3 1.3 5.0 -0.7 -0.4 -1.5 -1.4 0.5 0.9 -0.8 1.1 0.9 -2.2
Lung FVC 0.3 1.5 3.8 0.6 1.8 1.2 1.6 0.7 -0.6 1.2 -1.3 -0.1 2.0
Neuroticism 0.9 2.1 8.0 0.7 -2.8 -2.0 1.4 -1.3 -1.3 -1.0 -1.3 -1.0 -0.4
Chronotype (morning person) 0.5 1.2 5.3 1.3 0.8 0.8 0.1 1.3 0.5 -2.3 0.6 0.2 -1.2
Hair Pigment 0.0 0.9 3.2 0.1 -0.4 -0.6 0.5 1.2 1.8 0.1 1.1 0.7 -1.2
Tanning 0.1 0.9 5.3 0.5 -1.0 2.3 -0.3 0.9 -0.5 -0.5 -0.2 0.4 0.6
Hand grip strength (left) 0.2 0.5 2.6 -1.0 0.5 0.3 -0.4 0.9 0.4 0.5 0.4 1.6 -0.0
Number of treatments/medications taken 1.2 2.2 8.5 -2.9 -1.1 -1.6 -1.2 -0.4 0.9 0.2 1.7 1.1 -1.9
Average weekly spirits intake 1.4 1.7 5.9 1.1 1.5 -1.0 1.1 0.7 -1.4 0.6 -1.5 -2.4 0.8
Sensitivity / hurt feelings 0.5 0.9 2.3 0.2 -1.5 -0.9 -0.6 -1.3 -1.5 0.3 -0.1 0.0 -0.9
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.7 1.3 0.6 0.3 1.0 -0.3 0.2 1.0 0.1 -0.7 0.0
Hearing difficulty/problems: Yes 0.3 0.5 1.0 -1.0 0.9 -0.4 -1.0 0.1 -0.7 -0.2 0.8 0.1 -0.6
Relative age of first facial hair 0.7 1.4 4.0 0.9 1.6 1.3 -0.4 -0.9 0.6 2.0 -0.4 -0.2 1.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.3 -0.5 1.1 0.6 0.4 -0.2 -0.4 0.3 0.1 0.6 0.6
Ever used hormone-replacement therapy (HRT) 0.5 0.6 3.1 0.3 0.0 0.1 -0.9 -0.2 -0.0 -1.7 0.3 -0.9 -0.9
Ever had hysterectomy (womb removed) 0.8 0.9 2.9 -0.4 -1.2 -1.2 -0.6 -0.1 0.7 -1.7 -0.3 -0.9 -1.1
Systolic blood pressure, automated reading 0.4 1.2 3.6 -1.0 1.8 0.7 0.4 0.6 0.8 1.9 -0.4 -0.2 1.6
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 8.5 -0.3 0.2 1.4 0.5 2.9 1.7 1.6 1.0 2.1 0.0
Angina 3.6 4.8 12.1 -3.5 1.1 0.2 -2.4 0.9 1.3 1.9 3.3 2.9 -1.8
Medication for hormone replacement therapy 0.6 0.7 2.1 -0.4 1.1 0.1 -0.5 1.4 0.5 -1.0 0.4 -0.2 -1.4
Vitamin and mineral supplements 0.2 0.3 1.5 -0.2 -0.6 -0.6 -0.3 -0.5 0.3 -1.2 0.2 0.1 -0.8
Supplements: Zinc 0.4 0.4 1.1 0.3 0.3 0.6 -0.3 -1.0 -0.8 0.9 0.0 -0.0 1.1
Medication: Co-codamol 0.9 1.1 2.5 -0.2 -0.1 0.9 -1.2 -1.0 1.6 1.3 1.6 0.7 -0.7
Medication: Metformin 2.2 3.1 8.8 -2.2 -3.0 -2.2 -0.5 2.0 0.8 -1.2 0.8 1.3 -2.1
Diabetes (father) 0.9 1.1 3.5 -0.0 -1.9 0.5 0.2 0.5 1.5 -1.5 0.1 1.1 -1.1
Diabetes (mother) 2.0 2.5 7.2 -1.0 -2.7 -1.2 -1.2 1.1 1.3 -2.2 0.3 0.3 -2.4
Severe depression (siblings) 0.8 0.9 2.5 1.2 0.3 -0.5 1.3 -0.3 1.3 -0.9 -0.6 -1.6 -0.5
Pack years adult smoking proportion 0.4 0.6 2.1 -0.4 1.4 0.8 0.2 1.0 -0.7 0.2 -0.8 -0.7 0.8
Impedance of leg (right) 2.3 11.2 42.7 -3.7 -0.3 1.7 -3.0 3.5 6.5 -0.2 2.9 3.6 -3.2
Leg fat-free mass (left) 1.0 5.1 19.3 2.5 0.0 -1.0 2.9 -2.1 -4.4 0.3 -1.7 -1.7 2.4
Trunk fat percentage 0.1 0.4 1.4 0.9 0.6 0.4 1.2 0.7 -0.5 -0.3 -0.1 -0.0 0.3
Hand grip strength (right) 1.0 2.8 5.3 -1.9 1.2 0.7 -1.7 2.0 1.8 1.0 2.1 2.3 -1.3
Townsend deprivation index at recruitment 0.2 0.2 0.7 -0.0 -0.9 -0.2 -0.6 0.2 0.2 -0.3 0.8 0.1 -0.6
Current tobacco smoking 0.2 0.4 1.2 0.3 -0.7 0.9 0.8 -0.2 -0.3 -0.5 -0.0 -1.1 -0.1
Average weekly fortified wine intake 1.8 2.1 6.4 0.6 -1.3 -1.5 0.3 -1.4 -2.5 -0.7 -1.8 -2.1 0.8
Maternal smoking around birth 1.8 2.7 8.2 -1.3 0.0 1.2 -1.3 0.3 1.6 2.2 2.9 2.4 -0.7
Fed-up feelings 2.0 3.6 7.6 1.3 -2.1 -0.9 2.8 -2.0 -2.3 -0.3 -2.5 -1.8 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 3.8 0.1 0.9 0.6 1.3 -0.3 -1.0 2.0 -0.7 -0.3 1.4
Relative age voice broke 0.3 0.5 1.6 1.3 1.1 0.1 -0.3 0.2 0.2 1.2 -0.4 -0.6 0.1
Taking other prescription medications 1.0 1.6 6.5 -2.5 -0.8 -1.4 -0.2 -0.3 1.0 -0.9 0.8 0.9 -1.7
Age when periods started (menarche) 0.4 1.0 5.9 -1.0 -2.4 0.0 0.2 -0.5 -1.0 -1.0 -0.7 0.4 -0.1
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 5.5 -2.1 -1.6 -1.8 -1.0 2.3 2.3 -1.7 0.9 1.1 -2.3
Heel bone mineral density (BMD) T-score, automated (left) 2.5 5.6 16.9 2.6 0.9 1.1 4.1 -1.5 -0.7 -0.9 -3.1 -2.9 2.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.9 -0.9 -0.5 -0.3 -0.4 -0.6 -1.4 0.4 -0.1 0.0 -0.0
Qualifications: CSEs or equivalent 1.2 1.6 4.3 -0.9 0.9 -0.3 -1.0 1.9 0.0 0.6 1.8 2.1 -1.1
Serious illness, injury or assault to yourself 0.9 1.1 2.5 -1.1 -1.6 -0.8 -0.6 0.7 0.6 -1.5 0.4 1.1 -1.4
High blood pressure 0.7 2.0 6.0 -2.4 1.6 -0.2 -1.3 0.4 0.5 2.4 1.3 1.3 -0.1
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.5 0.6 -1.8 -1.8 1.2 -0.2 -1.0 -1.9 -1.3 -1.6 -0.7
Multivitamins +/- minerals 0.6 0.7 2.5 1.3 -0.3 0.3 1.6 0.5 0.1 -0.4 -1.3 -0.7 0.4
Stomach or abdominal pain in last month 0.7 0.8 2.5 -1.1 0.9 0.9 -1.0 -0.9 0.5 0.3 1.6 0.4 -1.0
Supplements: Glucosamine 0.7 0.9 1.7 0.9 -0.1 -0.4 0.6 -1.1 -1.2 0.5 -1.3 -1.3 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.5 0.0 1.2 0.1 -0.8 -0.1 -1.2 0.8 0.8 0.5 -0.7
Medication: Atenolol 1.3 1.6 5.0 -1.9 -0.6 0.3 -0.7 1.4 2.2 0.4 1.0 1.7 -0.5
Medication: Levothyroxine sodium 0.5 0.9 2.5 -0.8 0.5 0.3 -0.9 -1.4 0.0 1.6 0.9 1.3 0.1
Sitting height 0.5 3.7 11.4 2.2 -0.5 0.0 3.4 -1.0 -2.3 -0.7 -1.8 -2.3 2.2
Chronic bronchitis/emphysema (father) 0.6 0.7 3.0 -0.3 0.7 1.7 0.2 -0.8 0.3 0.6 -0.7 -0.1 1.3
High blood pressure (mother) 0.3 0.4 1.5 0.3 -0.8 1.2 -0.5 -0.4 0.8 -0.1 0.7 0.1 -0.3
Body mass index (BMI) 0.5 2.0 7.4 2.2 1.6 -0.2 1.4 -0.1 -2.7 0.7 -0.7 -1.4 0.8
Impedance of leg (left) 1.9 9.3 35.7 -3.8 -0.5 1.2 -2.7 3.1 6.0 -0.1 2.5 3.3 -2.7
Leg predicted mass (left) 0.9 4.9 19.3 2.5 0.1 -1.0 2.8 -2.1 -4.4 0.4 -1.6 -1.6 2.4
Trunk fat mass 0.3 1.2 3.6 1.6 0.5 0.0 1.9 -0.1 -1.8 -0.1 -0.6 -0.7 1.1
Waist circumference 0.2 0.6 3.1 0.5 -0.2 -1.2 0.6 0.2 -1.8 -0.1 0.1 -0.8 -0.4
Number of incorrect matches in round 0.7 1.1 2.3 -0.2 -0.8 1.5 -1.3 0.6 1.1 -0.9 1.2 1.3 -1.1
Past tobacco smoking 0.3 0.5 1.4 -0.4 -1.2 -0.7 -0.2 -0.3 -0.2 -1.0 -1.0 -0.5 0.3
Alcohol usually taken with meals 0.3 0.5 2.2 -0.0 -1.5 0.6 -0.6 -1.1 -0.4 0.2 0.3 -0.4 0.3
Nervous feelings 0.7 1.4 4.3 -0.8 -2.1 -1.7 -0.3 -1.7 -0.6 -0.2 -1.0 -1.2 0.3
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.8 7.5 1.3 -0.0 -2.0 2.7 -0.8 -2.1 -0.1 -2.1 -2.1 0.9
Hearing difficulty/problems with background noise 0.9 1.4 4.7 0.5 0.7 -1.6 0.6 -1.0 -2.2 -0.9 -1.2 -1.4 0.6
Hair/balding pattern: Pattern 2 0.9 1.1 3.1 -1.4 0.5 1.1 -1.1 0.2 0.9 0.5 1.2 1.8 -0.9
Had menopause 0.3 0.3 2.0 0.7 -0.3 0.1 -0.1 -1.4 0.7 0.1 0.4 -0.4 0.3
Had other major operations 1.4 1.7 4.3 -0.7 -1.3 -0.7 -1.6 0.5 0.5 -0.9 1.9 1.5 -2.1
Forced vital capacity (FVC) 0.3 1.2 6.0 0.7 -0.8 -0.4 2.4 -0.2 -0.6 -0.2 -1.2 -0.1 1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.1 11.1 2.6 1.1 1.5 3.3 -0.9 -0.5 -0.1 -2.5 -2.1 2.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.4 1.5 1.6 0.4 0.7 0.3 0.0 1.4 0.1 0.0 -0.0
Qualifications: None of the above 0.1 0.3 1.1 -0.3 1.1 0.2 0.2 -0.0 0.1 0.4 0.9 0.5 -0.1
Financial difficulties in last 2 years 0.9 1.3 4.5 -0.4 -1.2 -1.8 0.6 -0.3 -0.4 -2.1 -0.1 -0.6 -1.6
Mouth/teeth dental problems 2.4 3.7 15.1 -1.6 -0.1 0.3 -0.3 3.9 3.5 -1.0 0.4 1.5 -2.0
Heart attack 0.6 0.8 2.5 -1.1 -0.6 0.1 -1.6 -0.5 -0.3 0.7 1.4 1.1 -0.5
Allergy 0.8 1.9 4.5 0.9 2.1 1.9 -0.7 1.1 1.0 1.8 0.8 1.6 1.0
Pain all over the body in last month 1.1 1.1 3.4 -1.8 -1.4 0.9 -0.5 1.3 0.7 -1.3 -0.4 0.1 -0.8
Diabetes (self-reported) 1.0 1.6 9.7 -1.6 -3.1 -1.1 0.6 0.2 0.2 -0.9 0.3 0.7 -0.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 3.0 -0.8 -1.7 -0.0 0.1 0.3 0.0 -0.1 0.5 0.8 -0.1
Medication: Ramipril 1.0 1.3 4.2 -1.2 -0.8 -0.7 -1.5 0.8 0.8 0.2 1.5 0.9 -2.0
Medication: Simvastatin 2.1 3.1 6.5 -2.6 -1.8 -2.2 -2.3 0.2 0.2 -0.3 1.9 1.9 -2.0
Fluid intelligence score 0.7 1.4 4.7 -1.2 2.2 0.3 -1.3 0.0 1.4 1.1 1.2 0.9 -0.3
Illnesses of siblings 0.2 0.3 0.9 0.2 -0.8 0.1 -0.7 -0.2 0.8 0.1 -1.0 0.4 -0.1
Neuroticism score 0.9 1.9 4.3 0.1 -1.5 -1.7 1.7 -1.4 -2.1 -0.3 -1.6 -1.1 0.5
Weight 0.5 2.6 9.5 2.1 0.6 -0.6 2.3 -0.9 -3.1 0.2 -1.0 -1.3 1.4
Impedance of arm (right) 1.2 5.5 20.8 -2.2 -2.4 0.8 -1.4 1.6 4.6 -2.2 1.7 2.4 -2.3
Arm fat percentage (right) 0.2 0.6 2.5 1.6 0.8 0.4 1.2 0.6 -0.8 0.1 -0.2 -0.6 0.1
Trunk fat-free mass 1.1 6.1 17.1 2.9 0.5 -0.7 3.2 -2.1 -4.1 0.8 -2.2 -2.4 3.0
Hip circumference 0.4 1.6 7.5 1.5 0.6 -1.0 1.6 -0.1 -2.7 0.3 -0.9 -1.1 0.7
Time employed in main current job 0.8 0.9 2.6 -0.4 1.3 -0.8 -0.7 0.7 -1.4 1.6 0.6 0.8 0.6
Alcohol intake versus 10 years previously 0.3 0.4 1.3 0.3 -0.0 -1.1 0.1 0.1 -0.3 -1.1 -0.5 -1.0 -0.4
Father’s age at death 1.2 1.6 4.5 2.1 0.1 1.1 0.4 -1.8 -1.3 -0.5 -1.0 -2.0 0.3
Worrier / anxious feelings 0.8 1.4 4.6 -0.3 -1.3 -1.4 0.8 -1.5 -2.1 -0.6 -1.0 -1.3 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 7.1 -1.3 -2.7 -1.2 0.4 0.2 -1.8 -0.6 0.1 0.3 -1.0
Falls in the last year 0.4 0.6 2.3 -0.2 0.7 0.5 -0.2 -0.8 -1.5 0.5 -0.5 -0.4 1.3
Hair/balding pattern: Pattern 3 1.7 2.5 5.9 2.4 0.5 -0.8 2.4 0.2 -1.5 -0.3 -2.1 -1.8 1.6
Number of live births 0.6 0.8 3.2 0.3 -0.7 -0.1 -0.6 -0.0 0.3 -1.6 1.0 -0.6 -1.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.3 0.5 -1.0 -1.0 1.1 -0.0 -0.6 -0.3 -0.5 0.4 0.5
Pulse rate 0.9 1.6 4.9 1.1 0.7 -2.2 1.8 1.2 -0.9 -1.1 -0.8 -1.3 -0.3
Happiness 0.5 0.6 2.0 1.4 0.3 1.2 0.3 -1.2 -0.3 0.4 0.8 -0.5 0.4
Noisy workplace 0.2 0.2 1.0 1.0 0.3 -0.2 0.6 0.5 -0.3 0.2 -0.6 -0.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.4 0.9 4.7 -0.3 -2.2 -0.2 -1.1 -0.6 0.8 0.6 0.9 1.0 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.0 -0.4 -1.4 -1.2 -0.1 -0.7 -0.9 0.7 -0.4 -0.2 0.7
Mouth/teeth dental problems: Dentures 0.9 1.5 6.3 0.7 0.7 0.2 -0.9 -2.5 -1.7 1.3 1.0 -1.0 0.8
Asthma 0.6 1.3 3.0 -1.7 -1.7 -0.8 -1.0 -1.5 -1.1 -0.0 0.7 -0.3 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.2 4.8 1.9 -2.2 -1.4 2.1 1.0 0.1 -1.2 -1.8 -1.4 -0.2
Medication: Cholesterol lowering 2.1 3.3 15.5 -3.9 -1.3 -1.2 -2.1 -0.3 0.8 1.1 1.4 2.3 -0.4
Depression (self-reported) 0.4 0.5 1.7 -0.4 0.3 0.3 1.0 -0.7 -1.3 0.7 -0.0 -0.5 0.6
Medication: Lansoprazole 0.5 0.5 1.7 -1.0 -0.4 -0.0 -0.4 0.3 1.3 -0.0 0.1 1.1 -1.0
Prospective memory result 0.4 0.5 3.2 0.7 -1.8 -0.4 0.2 -0.4 0.0 0.5 -0.4 0.1 -0.4
Lung cancer (father) 0.2 0.2 0.7 -0.7 -0.0 0.7 -0.1 -0.3 0.2 0.8 0.1 0.5 0.5
Illnesses of mother 2.4 3.0 7.2 1.5 0.5 -0.1 2.1 -0.4 -2.3 0.6 -2.4 -1.8 2.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.1 0.2 -1.4 -0.4 1.2 0.1 -0.3 -0.9 -0.6 0.8 0.3
Pulse wave Arterial Stiffness index 0.5 0.6 1.8 -0.4 1.3 0.1 -0.1 -1.0 0.1 1.1 0.0 -0.3 1.3
Impedance of arm (left) 1.4 6.6 22.9 -2.8 -2.2 0.9 -1.9 1.5 4.8 -2.1 2.2 3.0 -2.3
Arm fat mass (right) 0.4 1.5 4.4 2.1 0.7 0.0 1.9 -0.3 -2.0 0.2 -0.7 -1.1 0.8
Trunk predicted mass 1.1 6.1 17.2 2.9 0.5 -0.8 3.2 -2.1 -4.2 0.7 -2.2 -2.4 2.9
Standing height 0.2 2.3 6.7 0.2 -1.7 -1.1 2.6 -1.9 -1.3 -1.1 -1.2 -0.4 2.0
Length of working week for main job 1.1 1.2 2.7 1.1 1.1 0.7 1.0 -0.3 -0.8 1.5 -1.4 0.2 1.6
Exposure to tobacco smoke at home 1.3 1.5 5.3 1.0 -0.3 -2.3 1.3 0.1 -1.0 -1.1 -1.0 -1.8 -0.2
Breastfed as a baby 1.6 2.0 6.6 0.3 0.5 1.0 0.8 -1.8 -1.7 2.0 -1.0 -0.6 2.6
Tense / ‘highly strung’ 0.5 0.8 2.3 -1.3 0.9 -0.1 0.4 -0.6 -0.4 1.4 -0.6 0.8 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.8 0.3 -1.0 -0.7 -0.3 -1.1 -1.1 -0.7 1.0 -1.3 -1.3
Hair/balding pattern: Pattern 4 0.3 0.7 1.4 1.1 0.1 0.1 0.7 -0.9 -1.1 0.2 -0.6 -1.2 1.1
Birth weight of first child 0.3 0.6 2.7 -0.8 -0.8 -1.6 0.8 -0.5 0.6 -0.2 -0.3 0.3 -0.4
Peak expiratory flow (PEF) 0.3 0.7 1.5 -0.2 -1.1 -0.8 -0.9 -0.6 -0.7 -1.2 0.8 0.7 -1.0
Pulse wave reflection index 0.4 0.6 2.0 0.4 1.4 0.2 0.3 -0.4 0.8 1.2 -0.7 -0.3 0.8
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.1 1.0 0.5 -0.8 1.2 1.4 -0.1 -0.7 -0.5 0.3 -0.7
Loud music exposure frequency 0.3 0.3 0.9 0.1 0.6 -0.5 -0.2 -0.9 -0.8 0.3 -0.6 0.5 0.0
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 9.5 -1.6 -3.1 -0.6 -1.4 -1.6 0.8 -0.1 1.1 1.6 -0.9
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 8.7 0.7 -0.4 -1.3 0.1 -1.0 -2.9 -0.1 -0.3 -1.0 0.6
Blood clot in the leg (DVT) 0.6 0.8 2.5 0.7 1.1 0.2 0.9 -1.0 -0.1 -0.4 -0.7 -1.6 1.1
Medication: Paracetamol 0.5 0.8 2.8 -0.3 -1.7 -0.9 1.1 -0.5 -1.1 -1.0 -0.7 -0.7 -0.4
Headache pain in last month 0.2 0.3 1.2 0.3 0.8 0.0 1.1 0.6 -0.1 0.4 0.3 -0.0 0.1
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 7.6 2.8 0.7 0.8 0.9 0.6 -0.2 -1.3 -1.0 -1.0 -0.1
Glaucoma (self-reported) 2.5 2.9 11.8 1.6 -1.7 -1.0 1.8 0.3 1.1 -3.4 -2.0 -1.1 -1.0
Gout (self-reported) 0.8 1.1 2.6 -0.6 1.6 1.4 -0.2 0.4 1.2 1.3 0.7 1.1 0.8
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 5.9 -1.2 1.5 0.4 -1.8 -0.4 0.8 2.0 1.9 2.4 -0.7
Medication: Amlodipine 0.5 0.7 2.0 -1.4 0.2 -0.2 -1.2 -0.5 0.8 0.2 1.2 0.9 -0.6
Medication: Ventolin 100micrograms inhaler 2.2 2.8 5.7 1.8 0.0 -0.2 1.4 -1.9 -2.4 1.3 -2.1 -2.0 2.0
Birth weight 0.3 0.7 2.0 0.7 -0.3 -0.8 0.9 -0.6 -0.5 -0.7 -1.4 -1.0 0.8
Chronic bronchitis/emphysema (mother) 0.4 0.4 2.4 -1.6 0.2 -0.2 0.2 -0.1 0.3 -0.7 0.8 0.4 -0.4
High blood pressure (siblings) 0.4 0.6 2.5 -0.1 -0.2 -0.5 1.1 -0.3 -1.3 -1.6 -0.3 -0.5 0.1
Forced vital capacity (FVC), Best measure 0.2 0.7 3.3 0.1 -0.9 0.4 1.8 0.0 -0.5 -0.4 -0.7 0.5 1.2
Body fat percentage 0.1 0.4 1.3 0.7 1.0 0.4 0.8 1.1 -0.3 0.1 0.3 0.2 -0.1
Leg fat percentage (right) 0.3 1.0 3.5 0.4 1.9 0.6 -0.1 1.7 0.2 0.8 1.0 0.6 -0.8
Arm fat-free mass (right) 1.0 5.3 17.3 2.5 0.7 -0.7 3.0 -1.9 -4.2 1.0 -1.8 -1.9 2.8
Exposure to tobacco smoke outside home 3.8 5.1 11.2 1.9 0.8 -2.3 3.1 -0.2 -2.9 -1.2 -3.4 -2.8 1.7
Comparative body size at age 10 0.3 0.8 3.6 -1.0 -1.2 -1.2 -0.4 0.5 -1.9 -0.1 -0.1 0.6 -0.4
Number of full brothers 0.9 1.1 2.8 -1.6 -0.4 0.3 -0.9 0.0 0.6 0.7 1.7 1.3 -1.3
Worry too long after embarrassment 0.5 0.9 3.2 -1.1 -1.8 -1.1 0.5 -1.4 -0.6 -0.7 0.4 -0.0 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.7 0.5 -0.2 0.6 1.4 -1.1 -0.5 0.3 -0.7 -1.6 1.1
Wheeze or whistling in the chest in last year 0.3 0.5 1.7 -0.8 -0.1 -0.5 0.3 -0.5 -1.3 0.0 -0.0 -1.1 -0.7
Number of children fathered 0.7 0.8 2.8 -0.7 1.7 -0.0 0.7 1.7 0.4 0.5 0.5 0.9 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 4.5 -2.1 0.2 -0.1 -0.6 0.7 0.3 0.1 0.6 0.9 -0.3
Age at first live birth 0.8 1.5 3.8 0.7 0.0 -1.3 1.9 0.8 -1.1 0.1 -1.9 -1.3 1.3
Pulse wave peak to peak time 0.5 0.6 1.8 0.7 -1.4 0.1 0.3 1.0 -0.0 -1.0 -0.0 0.4 -1.1
Health satisfaction 0.6 0.8 3.5 -0.2 -0.4 -1.9 -0.9 -0.4 -0.6 -0.1 0.8 0.0 -1.4
Shortness of breath walking on level ground 0.8 0.9 2.8 -1.7 0.9 0.2 -0.9 0.4 -0.9 0.8 1.2 1.2 -0.5
Qualifications: College or University degree 0.3 0.9 3.3 1.5 -1.8 0.1 0.1 -0.5 0.7 -1.1 -0.6 -0.9 -0.2
Eye problems/disorders: None of the above 1.0 1.1 3.2 -1.8 -0.8 0.7 -0.9 -1.3 -0.6 1.4 0.5 0.2 1.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.9 -0.8 -0.4 -1.6 -0.2 -0.4 -1.7 -0.6 -0.3 0.2 0.5
Emphysema/chronic bronchitis 1.0 1.1 3.6 -0.8 1.9 1.0 0.3 1.4 -0.1 1.8 -0.0 0.2 0.9
Medication for pain relief, constipation, heartburn 1.2 2.1 7.5 1.9 2.7 1.7 0.5 -0.2 0.3 0.9 -1.1 -0.3 2.2
Neck or shoulder pain in last month 0.5 0.6 2.0 -1.3 0.1 -0.2 -0.9 0.9 0.2 -0.4 1.4 0.1 -0.9
Medication: Blood pressure 0.3 0.5 1.9 -1.4 -0.2 -0.2 -0.8 -0.8 -0.3 0.9 0.5 0.2 0.1
Angina (self-reported) 3.6 4.8 13.4 -3.7 0.9 0.3 -2.4 0.7 1.0 2.1 3.3 2.9 -1.6
Migraine (self-reported) 1.0 1.2 3.0 -0.0 -1.7 -1.6 1.1 -1.0 -0.7 0.7 -1.0 -1.4 0.3
Medication: Ibuprofen 1.3 1.5 6.3 0.7 -2.5 -1.7 1.1 0.4 0.1 -1.3 -0.9 -0.8 -0.9
Medication: Allopurinol 0.3 0.4 0.7 0.2 0.9 0.4 0.6 0.5 0.7 0.7 -0.4 0.7 0.7
Medication: Omeprazole 0.6 0.7 2.6 -1.0 -0.3 0.3 -0.7 -0.6 -0.2 -1.3 1.0 -0.2 -1.6
Medication: Seretide 50 evohaler 0.4 0.4 2.4 0.7 -0.0 -0.2 0.3 0.0 -1.6 0.7 -0.2 -0.8 0.4
Mean time to correctly identify matches 1.3 2.6 7.1 1.2 0.3 -0.4 1.4 -1.9 -2.7 1.3 -1.5 -1.7 2.1
Heart disease (mother) 0.4 0.5 2.9 0.2 0.2 0.7 0.7 0.3 1.7 -0.8 0.1 0.4 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 4.6 -0.9 -2.1 -1.4 -0.5 -0.9 -0.1 0.2 0.3 0.3 -0.7
Whole body fat mass 0.2 0.9 3.3 1.3 0.8 -0.3 1.5 -0.0 -1.8 0.4 -0.3 -0.6 0.7
Leg fat mass (right) 0.3 1.0 2.6 1.5 1.4 -0.2 1.4 0.1 -1.6 0.7 -0.2 -0.5 0.4
Arm predicted mass (right) 1.1 5.6 17.6 2.5 0.9 -0.8 3.1 -1.9 -4.2 1.0 -2.0 -2.1 3.0
Pulse rate, automated reading 0.2 0.7 2.2 0.5 0.7 -0.5 1.5 0.8 -0.8 -1.0 -0.5 -1.2 0.5
Alcohol intake frequency. 0.3 0.7 2.3 1.2 -0.3 -0.4 0.2 -0.1 -1.5 -1.4 -0.5 -0.8 -0.6
Comparative height size at age 10 0.3 1.4 6.2 1.1 1.2 0.1 2.5 -0.7 -0.4 -1.0 -0.7 -0.0 1.8
Number of full sisters 0.9 1.1 2.8 -1.7 -0.8 -0.8 -1.4 -0.3 0.1 0.2 1.4 1.3 -1.2
Suffer from ‘nerves’ 0.2 0.3 0.9 0.1 -0.0 -0.9 0.9 0.3 -0.3 -0.1 -1.0 -0.8 0.4
Overall health rating 0.2 0.4 1.5 -0.3 -0.4 -0.6 0.1 -1.2 -1.0 -0.2 -0.6 -0.9 0.2
Chest pain or discomfort 0.6 0.8 3.4 -0.1 -1.1 0.0 0.3 -1.9 -1.5 -1.0 0.2 -0.4 0.1
Had major operations 0.6 0.7 2.4 -1.0 -0.1 1.0 -0.8 -0.5 -0.0 0.8 1.2 1.5 0.4
Age at last live birth 0.4 0.6 2.5 -0.5 -0.5 -1.6 0.7 0.5 -0.9 0.0 -0.6 -0.9 0.5
Family relationship satisfaction 0.7 0.8 3.1 1.8 1.3 1.2 1.1 -0.6 0.4 -0.4 -0.3 -0.5 0.3
Leg pain on walking 0.9 1.1 5.2 -0.3 -0.4 -1.6 -1.1 0.1 -2.3 0.2 -0.0 -0.1 -1.2
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 6.7 -1.8 -0.8 0.2 -2.1 1.4 -0.3 0.3 1.6 2.6 -1.8
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.5 -0.4 -0.6 -0.1 -0.3 1.6 -0.0 -0.4 1.0 0.9 -0.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.9 -0.1 1.4 -0.0 -0.7 -0.6 -0.2 1.1 0.3 -0.3 0.7
Medication: Aspirin 3.9 5.2 13.4 -3.7 -2.1 -1.2 -2.9 0.4 0.6 0.5 3.3 2.6 -2.5
Supplements: Vitamin C 0.5 0.6 1.5 -1.0 0.3 0.9 -0.7 0.1 0.1 1.2 0.9 0.6 0.5
Knee pain experienced in last month 1.1 1.7 8.0 0.0 -0.4 -1.6 -0.8 -2.2 -2.8 -0.0 -0.2 -0.8 -0.0
Hypertension (Self-reported) 1.0 2.7 7.6 -2.8 1.8 -0.4 -1.6 0.7 0.4 2.6 1.6 1.6 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.0 1.4 1.1 1.4 0.1 -0.4 0.7 1.7 0.2 -0.6 0.2
Illnesses of father: Heart disease 0.5 0.7 3.1 -1.8 -1.3 -0.7 -0.7 -0.2 0.1 0.1 0.6 0.6 -0.5
Illnesses of siblings: Diabetes 1.8 2.3 5.1 -1.7 -0.9 -1.1 -1.1 2.3 1.8 -1.1 1.1 1.1 -2.2
Smoking status: Previous 0.1 0.1 0.9 0.9 0.2 0.3 0.4 -0.1 -0.0 -0.2 0.3 -0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 5.7 -2.1 -2.4 -1.1 0.2 -0.8 -0.8 -0.8 -0.4 0.8 -0.3
Whole body fat-free mass 1.1 6.2 20.4 2.8 0.5 -0.8 3.2 -2.2 -4.5 0.8 -2.0 -2.1 2.9
Leg fat-free mass (right) 1.2 6.2 22.3 2.6 -0.1 -1.2 3.2 -2.5 -4.7 0.2 -2.0 -1.9 2.8
Arm fat percentage (left) 0.1 0.5 2.1 1.4 0.7 0.3 1.2 0.4 -0.9 0.1 -0.0 -0.5 0.2
Average weekly red wine intake 0.5 0.8 1.9 1.2 0.4 0.2 0.4 -0.5 -0.4 1.1 -1.1 -1.1 1.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 2.1 0.5 -0.2 -0.6 1.4 0.7 0.2 0.2 -0.0 0.7 0.3
Mood swings 0.9 1.6 7.2 0.3 -0.5 -0.6 1.2 -1.6 -2.7 0.3 -1.1 -0.8 1.3
Loneliness, isolation 1.5 2.1 5.0 1.5 -0.2 -0.7 1.7 -1.6 -2.2 -0.6 -1.2 -2.2 0.8
Long-standing illness, disability or infirmity 0.8 1.2 2.9 -0.0 -1.7 -1.3 0.7 -0.6 -1.2 -1.7 -1.1 -0.6 -0.8
Ever had bowel cancer screening 0.7 0.9 3.0 -1.7 0.5 -0.5 -1.7 -0.5 -0.6 0.2 1.1 -0.2 -0.8
Diabetes diagnosed by doctor 1.2 2.0 14.2 -1.2 -3.8 -1.3 0.8 -0.2 -0.1 -1.2 -0.3 0.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 10.7 3.3 0.3 0.6 1.5 0.6 0.5 -0.4 -0.6 -1.5 0.1
Friendships satisfaction 0.8 1.0 2.7 1.1 1.3 1.6 0.8 -1.3 0.1 -0.9 -0.8 -0.5 0.8
Qualifications: nursing, teaching 0.5 0.8 4.9 -0.3 -0.6 0.2 -0.9 -2.2 0.6 -0.9 0.6 0.5 -0.1
Commuting to job workplace: Walk 0.5 0.6 1.7 -0.6 -1.3 0.1 -0.6 -1.3 0.5 -0.8 0.5 -0.5 -0.5
Eye problems/disorders: Cataract 0.4 0.4 1.0 0.8 -0.3 -0.9 0.1 0.6 0.4 -0.9 -0.5 -0.0 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 1.4 0.2 0.2 0.6 -0.2 -1.2 -0.2 0.1 0.7 -0.0 0.3
Medication for cholesterol 3.2 4.8 10.5 3.0 -1.4 -0.5 3.0 -1.7 -1.4 -1.6 -3.2 -2.5 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 4.6 -1.7 0.4 -0.1 -1.9 0.9 0.5 -1.0 1.7 2.1 -1.7
Back pain experienced in last month 0.5 0.7 3.0 0.0 -0.7 -1.7 0.1 0.4 0.1 -0.6 0.4 -0.1 -1.6
Mineral and other dietary supplements 0.1 0.1 0.7 0.1 0.1 0.0 -0.1 -0.0 -0.1 -0.9 0.1 -0.2 -0.1
Breast cancer (self-reported) 1.5 1.8 5.1 -2.3 -1.0 -1.6 -0.3 0.8 0.8 -1.8 0.3 1.3 -1.7
Asthma (self-reported) 0.6 1.3 3.7 -1.4 -1.8 -0.8 -0.6 -1.9 -1.5 -0.1 0.3 -0.6 -0.5
Osteoporosis (self-reported) 0.2 0.3 1.2 0.0 -0.7 0.3 -0.2 0.4 -0.3 -0.5 0.8 0.2 -1.1
Osteoarthritis (self-reported) 1.7 2.2 5.8 -0.9 -2.0 -2.4 -0.7 -2.1 -2.3 -0.6 -0.7 -0.6 -0.3
Medication: Aspirin 4.7 6.1 15.6 -4.0 -1.9 -0.8 -3.4 0.8 0.8 0.5 3.5 2.9 -2.8
Medication: Gliclazide 0.6 0.7 2.9 -0.9 -1.4 -0.7 0.5 0.2 -0.1 -1.7 -0.9 0.1 -0.1
Illnesses of father: None of the above (group 1) 0.8 1.0 4.8 2.2 0.9 0.0 0.9 1.1 -0.5 -0.3 -0.9 -1.2 0.3
Smoking status: Current 0.2 0.4 1.1 0.3 -0.3 0.9 1.0 -0.3 -0.5 -0.1 -0.2 -1.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.9 1.7 -0.5 -0.4 1.3 0.1 -0.7 -1.4 -1.3 -1.2 0.2
Whole body water mass 1.1 6.1 19.9 2.9 0.5 -0.8 3.1 -2.1 -4.5 0.9 -2.0 -2.2 2.9
Leg predicted mass (right) 1.1 6.1 22.5 2.6 -0.1 -1.2 3.1 -2.4 -4.7 0.3 -2.0 -1.9 2.7
Arm fat mass (left) 0.3 1.4 4.1 1.9 0.6 -0.2 1.8 -0.2 -2.0 0.3 -0.6 -1.0 0.9
Number of self-reported non-cancer illnesses 1.2 2.0 5.5 -2.3 -2.1 -0.5 -1.1 -1.0 0.8 0.3 1.9 1.5 -1.1
Average weekly champagne plus white wine intake 1.7 2.4 9.2 1.5 -0.9 0.9 0.4 -3.0 -2.5 1.0 -0.6 -1.2 1.2
Miserableness 0.5 0.9 3.4 1.0 -1.0 0.2 1.8 -0.7 -1.2 -0.5 -0.9 0.0 0.8
Guilty feelings 0.6 0.9 2.6 0.2 -0.4 -0.7 1.3 -1.6 -0.6 0.0 -1.6 -0.6 1.0
Wears glasses or contact lenses 1.0 1.1 4.3 2.1 -0.4 0.6 1.7 -0.5 -0.3 -1.3 -0.7 -0.8 0.5
Ever taken oral contraceptive pill 1.4 1.5 5.0 2.0 1.0 1.8 0.5 2.2 0.9 0.3 0.3 0.7 -0.1
Hearing aid user 0.9 1.1 3.0 -0.2 0.9 0.2 -1.7 0.6 0.6 1.0 1.3 1.4 -1.2
Mother’s age at death 1.2 1.5 3.7 0.6 -0.5 -0.7 1.6 -0.9 -0.6 -0.6 -1.9 -1.9 1.5
Financial situation satisfaction 0.9 1.2 2.4 -1.1 1.0 -1.0 -1.1 -1.2 -0.3 1.5 1.5 0.8 -0.6
Tinnitus: Yes, now most or all of the time 2.1 2.5 5.8 -2.0 -1.6 -2.4 -1.8 0.3 0.2 -1.6 0.9 0.2 -2.4
Commuting to job workplace: Public transport 0.6 0.7 2.0 -1.0 0.3 -1.1 -1.0 -1.4 -0.9 0.5 0.2 0.4 -0.6
Eye problems/disorders: Glaucoma 2.2 2.6 9.6 1.9 -1.3 -0.7 1.9 0.1 0.9 -3.1 -1.9 -1.5 -0.8
Medication: Blood pressure 1.0 1.8 3.2 -1.8 1.3 0.0 -1.5 1.1 1.1 1.3 1.8 1.7 -1.0
Pain type(s) experienced in last month: Hip pain 0.9 1.1 3.6 0.5 1.9 -1.0 -0.8 -0.2 -0.1 1.0 1.5 0.1 -1.6
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.7 0.2 0.5 -0.4 0.4 -0.8 -0.3 0.8 -0.2 -0.3 0.2
High cholesterol (Self-reported) 2.3 4.1 12.5 -3.5 -0.6 -0.5 -3.0 -0.1 1.6 1.9 2.6 2.2 -1.2
Medication: Bendroflumethiazide 0.4 0.6 1.6 -1.2 0.9 -0.4 -0.2 -0.5 1.3 0.4 0.5 1.2 0.1
Medication: Paracetamol 0.2 0.3 0.8 -0.5 -0.9 -0.8 0.7 -0.7 -0.3 -0.0 -0.3 -0.2 -0.5
Medication: Lisinopril 0.8 1.1 2.5 -1.6 0.9 0.4 -0.5 1.3 1.0 1.1 1.2 1.2 -0.4
Medication: Atorvastatin 1.6 2.0 5.7 -2.4 0.0 1.3 -1.0 -1.3 1.2 1.9 0.3 1.4 1.6
Illnesses of father: High blood pressure 0.9 1.1 3.1 -0.7 -0.8 -0.1 -1.2 0.2 1.4 0.1 1.7 0.6 -1.8
Alcohol drinker status: Never 1.4 1.6 7.5 1.4 0.6 -0.4 -0.0 -1.0 -2.7 -0.2 -0.9 -2.0 0.8
Ever smoked 0.4 0.8 2.8 0.6 1.7 1.0 0.1 0.7 0.1 1.2 1.1 0.1 -0.5
Basal metabolic rate 0.9 4.8 16.6 2.5 0.5 -0.8 2.9 -1.8 -4.1 0.7 -1.7 -1.8 2.5
Leg fat percentage (left) 0.1 0.5 2.3 0.4 1.5 0.3 0.2 1.2 -0.3 0.6 0.5 0.2 -0.5
Arm fat-free mass (left) 1.0 5.0 16.6 2.3 0.6 -1.0 2.9 -1.7 -4.1 0.9 -2.0 -2.1 2.5
Number of operations (self-reported) 1.8 2.7 6.2 -1.8 -2.5 -2.2 -0.9 -0.4 -0.4 -2.5 1.1 0.7 -1.8
Average weekly beer plus cider intake 0.9 1.3 3.5 -1.4 1.9 -0.0 -1.5 -0.1 0.5 1.8 0.9 1.2 -0.1
Irritability 0.3 0.5 2.1 -0.2 -0.0 -0.0 0.7 -0.7 -1.5 -0.2 -0.8 0.1 1.0
Risk taking 0.8 1.2 5.5 -0.1 -2.3 -0.9 0.9 -0.7 -1.3 -1.5 -0.7 -0.1 0.0
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.9 -0.9 0.8 -0.0 -0.2 0.4 -0.2 -0.0 0.1 0.2 -0.5
Fractured/broken bones in last 5 years 1.5 1.9 4.6 -2.0 0.2 -0.6 -2.0 0.1 1.2 0.3 2.1 1.7 -1.3
Age started oral contraceptive pill 0.5 0.6 2.7 -0.4 0.9 0.8 -0.7 0.2 1.6 -0.8 0.6 0.4 -0.3
Diastolic blood pressure, automated reading 0.9 2.9 9.1 1.0 3.0 1.5 1.8 0.8 -0.5 2.3 -0.9 -0.6 2.4
Ever depressed for a whole week 0.4 0.5 1.4 -0.4 0.4 -0.0 -0.9 -0.6 -1.0 1.2 0.6 -0.4 -0.5
Unable to work because of sickness or disability 1.2 1.5 5.0 -1.7 -2.2 -1.1 0.1 -1.6 -0.7 -1.1 -1.0 -0.8 0.6
Commuting to job workplace: Cycle 1.0 1.2 4.7 0.6 0.8 1.5 0.7 -1.0 2.2 0.0 -0.4 -0.2 1.6
Myopia 0.7 1.0 3.5 -0.4 -1.7 -0.9 -0.2 -0.8 -0.5 -1.9 -1.1 -0.1 -0.2
Vascular/heart problems diagnosed by doctor 0.8 2.1 6.4 2.2 -1.6 -0.0 1.5 -0.2 -0.5 -2.5 -1.7 -1.3 0.1
Cholesterol lowering medication 3.2 4.8 10.8 -3.0 -0.4 -0.1 -3.2 1.1 1.4 0.7 3.3 2.8 -2.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.5 -0.6 0.1 0.7 -0.4 -0.4 -0.1 -1.6 0.7 -0.7 -1.3
Pain experienced in last month 0.8 1.3 3.3 1.8 1.3 1.0 1.1 -0.3 0.4 0.8 -1.3 -0.3 1.7
Supplements: Calcium 1.4 1.6 7.4 -2.7 -0.7 -1.1 -1.7 0.9 0.3 -0.4 0.6 1.1 -1.1
Basal cell carcinoma (self-reported) 0.8 1.0 5.8 -0.1 -1.1 -0.1 -0.3 -0.8 -0.1 -2.4 0.8 -0.5 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.1 3.1 -1.0 -0.7 0.5 -1.8 -0.6 0.0 0.8 1.7 1.3 -0.6
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.8 1.2 1.0 0.0 1.3 -1.1 -0.4 -0.6 -1.2 -2.0 1.3
Heart disease (siblings) 0.4 0.5 2.5 0.1 1.6 -0.7 0.8 -0.0 -0.7 -0.1 0.2 -0.6 0.2
Alcohol drinker status: Previous 1.0 1.2 4.0 -0.4 -1.5 1.0 -0.9 -0.0 1.1 -1.1 0.3 2.0 -0.8
Pack years of smoking 0.4 0.6 1.9 -0.2 1.4 1.0 0.1 0.5 -0.7 0.2 -0.8 -0.8 1.0
Impedance of whole body 1.8 9.0 32.6 -3.5 -1.8 0.9 -2.3 2.6 5.7 -1.4 2.5 3.5 -2.9
Leg fat mass (left) 0.2 0.9 3.4 1.2 1.1 -0.5 1.3 0.0 -1.9 0.6 -0.2 -0.6 0.4
Arm predicted mass (left) 0.8 4.3 14.1 2.3 0.5 -0.9 2.7 -1.5 -3.8 0.7 -1.8 -2.0 2.2