Hub : Genes

KCNK6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1210 0.0480 4.8e-03 0.010 NA 0.017 NA 0.014 5.1e-02 NA 1.8e-02 NA 2.8e-02
2 GTEx Colon Transverse 0.2090 0.0750 1.1e-03 -0.001 NA -0.001 NA 0.006 3.6e-01 NA 3.8e-01 NA 1.5e-01
3 GTEx Spleen 0.1730 0.0680 4.8e-03 -0.005 NA -0.012 NA -0.006 4.5e-01 NA 9.8e-01 NA 5.0e-01
4 GTEx Testis 0.4070 0.0900 1.3e-06 0.165 NA 0.104 NA 0.118 8.4e-08 NA 2.3e-05 NA 6.7e-06
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0336 0.0206 5.9e-04 0.021 0.02 0.016 NA 0.022 1.7e-03 0.00250 6.2e-03 NA 1.5e-03
6 TCGA Pheochromocytoma and Paraganglioma 0.0690 0.0400 2.1e-03 0.045 0.07 0.067 NA 0.056 6.8e-03 0.00094 1.3e-03 NA 3.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.3 2.1 3.6 -1.2 0.2 -1.4 -1.6 -1.7 -1.9
Bipolar Disorder or Schizophrenia 1.7 4.1 6.4 0.5 -0.2 -2.5 -2.5 -2.3 -2.5
Depressed Affect (Nagel 2018) 0.2 0.5 1.8 1.4 -0.0 0.4 0.5 0.3 0.8
Depression (Nagel 2018) 0.1 0.2 0.7 -0.1 -0.1 0.1 -0.8 -0.4 0.5
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.5 -1.6 0.7 0.8 0.5 0.9 -0.2
Neuroticism (Nagel 2018) 0.6 1.3 3.3 1.0 -0.4 1.0 0.6 1.4 1.8
Schizophrenia (2018) 1.3 2.8 4.6 1.6 -0.3 -2.1 -1.9 -1.6 -1.7
Schizophrenia vs Biploar Disorder 0.6 0.8 3.6 1.9 -0.3 0.5 0.2 0.5 0.8
Worry (Nagel 2018) 1.2 2.6 5.5 1.1 -0.1 1.5 1.5 2.1 2.3
Alzheimer’s Disease (in mother) 0.6 0.7 2.3 -0.6 1.5 0.6 0.4 1.1 0.1
Alzheimer’s Disease (in father) 0.6 0.7 1.4 0.4 -0.1 0.9 1.2 0.7 1.0
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 0.4 0.8 0.6 0.5 0.7 -0.1
Crohns Disease (2017) 0.4 0.8 2.2 -0.4 1.5 -1.3 -0.4 -0.2 -0.9
Irritable Bowel Disease (IBD) 1.2 2.9 7.6 1.1 -0.1 -2.8 -1.9 -1.2 -1.8
Ulcerative Colitis (UC) 1.3 2.5 4.7 1.4 -1.0 -2.2 -2.1 -1.0 -1.3
Major Depression (MDD) 0.6 0.8 1.7 1.0 -0.1 -1.3 -1.1 -0.4 -0.9
Reaction Time 1.3 2.6 5.3 0.4 2.3 1.5 2.1 1.4 1.0
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.6 -0.3 -0.5 -1.1 -1.2 -0.6 -1.3
Breast Cancer 0.1 0.2 0.4 -0.3 -0.6 -0.5 0.1 -0.5 -0.2
Ovarian Cancer 0.3 0.4 0.9 -1.0 0.2 -0.5 -0.9 -0.2 -0.7
Prostate Cancer 2.3 3.2 12.3 -0.6 0.2 -3.5 -2.6 0.0 0.0
Age at First Birth 0.2 0.3 1.3 0.2 1.1 0.3 0.7 0.2 0.2
Bipolar Disorder (2011) 0.2 0.2 1.2 0.3 1.1 -0.2 0.2 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.2 1.1 0.1 -0.5 -0.8 -0.9 -1.1
Coronary Artery Disease (CAD) 0.6 0.7 1.1 0.8 -1.0 0.5 0.7 1.1 0.9
Crohns Disease (2012) 0.4 0.7 1.4 0.6 0.8 -1.2 -0.6 -0.3 -1.1
Mean Putamen Volume 1.4 1.7 2.9 -1.5 1.6 1.7 0.7 1.0 0.7
Fasting Glucose 1.9 2.3 4.2 -0.1 2.0 1.9 1.1 1.6 1.4
HbA1C 0.7 0.8 1.6 1.0 -1.3 -0.7 -0.9 -0.7 -0.2
HDL Cholesterol 0.2 0.3 1.6 0.4 1.3 -0.0 0.3 0.3 0.2
LDL Cholesterol 0.2 0.3 1.5 0.5 1.2 -0.1 0.3 0.3 -0.0
Lupus 0.3 0.4 1.5 1.2 -0.7 -0.4 0.3 -0.6 -0.1
Neuroticism (2016) 1.0 1.4 4.4 2.1 -0.2 0.6 1.0 0.9 1.4
Primary Biliary Cirrhosis 0.4 0.6 1.7 -0.7 -0.6 -0.2 -1.3 -0.7 -0.6
Rheumatoid Arthritis 0.2 0.3 0.6 0.8 -0.3 -0.7 0.1 -0.5 -0.7
Schizophrenia (2014) 1.1 2.4 3.5 1.6 -0.7 -1.7 -1.9 -1.7 -1.5
Triglycerides 0.1 0.2 0.7 -0.3 0.0 0.8 0.0 0.3 0.4
Type 2 Diabetes (T2D) (2012) 0.0 0.1 0.2 0.5 0.2 -0.0 -0.2 -0.2 0.0
Ulcerative Colitis 2.5 3.7 5.1 2.2 -2.2 -2.2 -2.0 -1.4 -1.1
Blood Eosinophil Count 0.8 6.0 16.8 4.1 -1.9 2.1 -1.4 1.9 2.4
Blood Platelet Count 7.6 87.7 163.8 1.9 3.8 12.8 10.6 10.1 11.4
Blood Red Count 0.1 0.8 2.0 0.1 -0.8 -1.4 0.0 -1.0 -1.0
Blood White Count 0.1 0.8 2.4 1.5 -0.9 -0.8 -0.4 0.0 0.9
Heel T-Score 0.2 1.7 4.2 0.5 -1.1 -2.0 -0.9 -1.4 -1.2
BMI 1.1 6.5 21.6 0.5 -4.7 -1.3 -2.9 -2.6 -0.1
Height 0.1 1.1 2.7 -1.2 1.1 -0.6 -1.6 0.3 -0.9
Waist Hip Ratio (WHR) 0.7 2.9 7.9 -0.2 -1.4 -2.8 -1.8 -1.7 -1.3
Systolic Blood Pressure 0.7 3.5 5.7 2.4 -1.2 -2.2 -2.2 -0.9 -1.9
Smoking Status 2.0 4.7 7.8 1.2 -2.8 -2.6 -2.6 -2.1 -1.0
Allergy or Eczema 0.6 1.7 3.4 1.2 0.7 1.6 1.0 1.9 1.1
Cardiovascular Disease 0.9 3.0 6.6 2.4 -2.6 -0.9 -1.9 -1.0 -0.5
Hypothyroidism (self reported) 0.1 0.3 1.0 0.5 -0.6 0.4 -0.3 0.4 1.0
Respiratory disease 0.5 1.0 2.6 0.7 1.6 1.5 0.7 0.6 0.3
Type 2 Diabetes (T2D) (2018) 0.5 1.0 4.8 2.2 -0.8 -0.3 -0.4 0.1 0.1
Lung FEV1/FVC ratio 0.1 0.7 2.0 1.3 -0.4 1.4 0.1 -0.4 0.4
Lung FVC 0.1 0.3 0.6 -0.4 0.2 -0.8 0.3 0.7 0.3
Neuroticism 1.1 2.6 6.2 1.3 -1.1 1.3 1.0 2.0 2.5
Chronotype (morning person) 0.4 0.8 2.9 0.0 1.2 0.6 1.7 0.4 -0.2
Hair Pigment 0.0 0.5 1.3 1.2 -0.5 -0.3 -0.7 0.2 1.0
Tanning 0.1 1.2 4.1 -2.0 1.2 0.3 1.1 0.5 0.3
Hand grip strength (left) 0.1 0.3 0.5 -0.7 -0.7 0.6 -0.3 0.4 0.0
Number of treatments/medications taken 0.7 1.3 4.3 0.1 -2.1 -0.5 -1.7 -0.7 0.1
Average weekly spirits intake 0.1 0.1 0.4 0.1 0.3 0.3 -0.3 0.7 0.2
Sensitivity / hurt feelings 1.5 2.5 3.7 1.6 -1.9 1.7 1.2 1.1 1.8
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.0 -0.5 -0.6 -0.5 -1.2 -1.4 -0.8
Hearing difficulty/problems: Yes 0.3 0.4 0.8 0.3 -0.7 -0.6 -0.8 -0.9 -0.4
Relative age of first facial hair 0.0 0.0 0.1 -0.0 0.1 0.0 0.1 -0.2 -0.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.7 0.8 -0.3 -0.7 -1.3 -1.1 -0.4
Ever used hormone-replacement therapy (HRT) 1.6 2.0 3.6 0.3 -1.0 -1.9 -1.7 -1.5 -1.6
Ever had hysterectomy (womb removed) 2.4 2.7 4.3 1.3 -1.0 -2.1 -1.9 -1.3 -2.1
Systolic blood pressure, automated reading 0.9 2.6 5.5 1.0 -1.2 -1.9 -2.3 -1.0 -1.6
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.4 1.6 -0.7 1.0 -0.0 1.0 1.5
Angina 1.1 1.4 3.8 0.6 0.4 1.6 1.9 0.5 1.2
Medication for hormone replacement therapy 0.0 0.0 0.0 0.1 0.1 0.0 -0.2 0.0 -0.0
Vitamin and mineral supplements 0.3 0.3 1.3 1.1 -0.1 0.2 -0.8 -0.0 -0.4
Supplements: Zinc 0.2 0.2 0.5 0.2 -0.3 -0.6 -0.2 0.5 0.7
Medication: Co-codamol 2.5 2.9 5.2 0.2 -2.3 -1.7 -2.2 -2.0 -0.9
Medication: Metformin 0.6 0.9 4.6 2.2 0.1 0.1 0.1 0.7 0.6
Diabetes (father) 0.9 1.2 1.9 -1.3 -0.2 -1.3 -0.4 -1.4 -1.2
Diabetes (mother) 0.4 0.5 1.1 -0.8 -0.6 -0.0 -1.1 -1.0 -0.3
Severe depression (siblings) 0.6 0.7 2.9 -1.7 0.7 -0.1 0.1 -0.8 -0.5
Pack years adult smoking proportion 0.8 1.2 4.6 2.1 -0.9 -0.3 -0.1 0.7 1.1
Impedance of leg (right) 0.1 0.3 0.7 0.1 0.7 -0.8 0.2 0.3 -0.8
Leg fat-free mass (left) 0.4 2.1 5.0 0.0 -2.2 -0.5 -2.2 -1.6 -0.3
Trunk fat percentage 1.1 4.5 8.6 0.0 -2.8 -1.3 -2.8 -2.9 -1.2
Hand grip strength (right) 0.2 0.4 1.4 -0.5 -1.2 0.4 -0.8 0.2 -0.0
Townsend deprivation index at recruitment 0.6 0.9 1.8 -0.3 -0.7 -1.0 -1.3 -1.2 -0.8
Current tobacco smoking 0.9 1.5 2.9 1.0 -1.4 -1.7 -1.7 -0.7 -0.3
Average weekly fortified wine intake 0.7 0.8 3.8 -0.1 1.9 -0.4 -0.3 -0.0 -0.7
Maternal smoking around birth 1.3 1.8 3.4 -1.0 -0.7 -1.2 -1.2 -1.7 -1.8
Fed-up feelings 0.1 0.2 0.4 0.3 -0.3 -0.5 -0.2 -0.6 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 -0.4 -0.6 0.5 -0.7 -0.2 0.8
Relative age voice broke 0.1 0.2 0.6 0.5 -0.8 0.2 -0.2 0.2 0.3
Taking other prescription medications 0.7 1.1 2.6 1.6 -1.2 -0.6 -1.5 0.1 0.3
Age when periods started (menarche) 0.4 0.9 3.2 -0.0 1.8 -0.2 -0.5 -0.3 -1.3
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.7 -1.3 -0.2 0.3 -0.2 0.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.0 0.6 1.1 1.3 0.7 1.4 1.3
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.2 -0.4 -1.2 -1.1 -0.8 -1.8 -1.5
Qualifications: CSEs or equivalent 0.8 1.0 2.8 0.5 -1.0 1.7 0.4 0.5 1.3
Serious illness, injury or assault to yourself 0.4 0.4 1.2 -0.1 -0.0 1.1 -0.1 0.6 1.1
High blood pressure 0.8 2.2 3.8 1.4 -1.9 -1.3 -1.9 -1.1 -1.0
Hayfever, allergic rhinitis or eczema 0.7 1.4 2.6 0.9 1.3 1.5 0.6 1.6 1.0
Multivitamins +/- minerals 1.0 1.3 2.4 -1.6 -1.3 -1.5 -0.5 -1.0 -0.5
Stomach or abdominal pain in last month 0.5 0.7 1.8 -0.8 -1.4 -0.4 -0.8 -0.6 -0.6
Supplements: Glucosamine 0.3 0.4 0.5 -0.6 -0.6 0.7 0.7 0.5 0.6
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.4 0.7 -0.0 -1.4 -0.7 -1.1 -2.1
Medication: Atenolol 2.0 2.5 4.4 -0.0 0.2 1.9 1.7 2.0 2.1
Medication: Levothyroxine sodium 0.1 0.1 0.4 0.6 0.0 -0.2 -0.2 0.1 0.4
Sitting height 0.2 1.1 1.9 -0.5 0.5 -1.1 -1.4 -1.1 -1.3
Chronic bronchitis/emphysema (father) 0.1 0.2 0.3 0.5 0.5 -0.4 -0.2 -0.3 -0.4
High blood pressure (mother) 0.2 0.3 0.9 0.9 0.3 0.0 -0.9 0.2 0.3
Body mass index (BMI) 1.3 5.4 15.2 -0.1 -3.9 -0.9 -2.7 -2.9 -0.6
Impedance of leg (left) 0.1 0.3 0.7 -0.0 0.8 -0.8 0.2 0.4 -0.7
Leg predicted mass (left) 0.4 1.9 4.6 -0.0 -2.1 -0.4 -2.1 -1.5 -0.1
Trunk fat mass 1.6 6.7 12.3 -0.2 -3.5 -1.6 -3.4 -3.4 -1.5
Waist circumference 1.9 6.8 12.5 -0.7 -3.5 -1.9 -3.2 -3.4 -1.5
Number of incorrect matches in round 1.6 2.7 5.6 2.4 1.7 1.4 1.5 1.7 0.9
Past tobacco smoking 1.5 2.8 4.7 -0.2 1.9 2.1 2.2 1.8 1.1
Alcohol usually taken with meals 0.9 1.4 3.7 0.3 1.9 1.5 1.2 0.8 0.4
Nervous feelings 2.0 3.7 8.1 0.5 0.5 2.1 1.8 2.4 2.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.5 0.3 -1.2 -0.7 -0.9 -0.9 -0.4
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.5 0.4 0.2 0.4 0.0 0.1
Hair/balding pattern: Pattern 2 0.7 0.9 1.7 1.3 1.2 0.3 0.7 1.3 0.5
Had menopause 0.3 0.3 0.9 0.5 1.0 0.4 0.1 0.7 0.3
Had other major operations 3.5 4.3 8.6 1.2 -2.0 -1.8 -2.9 -2.2 -2.0
Forced vital capacity (FVC) 0.1 0.5 1.4 0.0 0.2 -1.2 -1.0 0.1 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.1 0.1 0.8 1.0 0.0 0.9 0.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.3 -0.5 -0.0 -0.2 0.2 0.5
Qualifications: None of the above 0.1 0.2 0.9 -0.2 -1.0 -0.3 0.0 -0.4 0.1
Financial difficulties in last 2 years 0.5 0.7 2.3 -1.5 -0.8 -0.2 -0.7 0.4 0.7
Mouth/teeth dental problems 0.3 0.5 1.3 -0.4 1.2 -0.7 -0.1 -0.6 -0.7
Heart attack 0.4 0.5 0.6 0.6 -0.6 0.7 0.8 0.6 0.8
Allergy 0.5 1.2 1.9 -1.4 -1.1 -1.2 -0.4 -1.2 -0.8
Pain all over the body in last month 1.7 1.8 6.5 1.1 -2.5 -0.6 -1.4 -0.9 0.4
Diabetes (self-reported) 1.1 1.6 5.9 2.4 -1.4 -0.7 -1.1 -0.4 -0.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.3 -0.0 0.2 -0.9 -1.1 -0.6 -1.2
Medication: Ramipril 0.1 0.1 0.2 0.5 -0.3 -0.1 0.1 -0.5 -0.2
Medication: Simvastatin 0.4 0.6 1.5 1.2 -1.0 0.4 -0.2 -0.7 -0.5
Fluid intelligence score 0.3 0.6 1.6 -0.5 -0.4 -0.9 -0.9 -0.5 -1.2
Illnesses of siblings 0.1 0.2 0.6 -0.8 0.2 -0.2 0.5 0.1 0.3
Neuroticism score 0.5 1.0 2.9 0.9 -1.7 0.0 -0.2 0.6 1.3
Weight 1.2 6.0 12.2 -0.6 -3.5 -1.4 -3.2 -3.1 -1.2
Impedance of arm (right) 0.3 1.2 5.8 0.0 2.4 -0.6 0.4 0.4 -0.7
Arm fat percentage (right) 1.7 6.5 14.4 0.2 -3.8 -1.4 -3.0 -3.5 -1.2
Trunk fat-free mass 0.3 2.0 5.6 -0.6 -2.4 -0.5 -1.9 -1.4 -0.3
Hip circumference 1.1 4.6 9.9 -1.0 -2.4 -1.3 -3.1 -2.8 -1.2
Time employed in main current job 2.7 3.1 6.7 0.5 1.5 2.6 1.5 1.7 1.9
Alcohol intake versus 10 years previously 0.2 0.3 0.7 0.8 -0.4 0.0 0.8 0.3 0.7
Father’s age at death 0.2 0.2 0.5 0.3 -0.6 -0.7 -0.1 0.1 -0.5
Worrier / anxious feelings 1.3 2.5 4.7 0.5 -0.2 1.5 1.9 2.1 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.1 0.3 -0.9 0.7 0.3 -0.0 1.0
Falls in the last year 0.4 0.5 1.6 0.0 -1.1 0.4 0.4 0.2 1.3
Hair/balding pattern: Pattern 3 0.4 0.7 2.4 -0.0 -0.1 1.5 0.6 0.5 1.0
Number of live births 0.6 0.8 2.4 -0.4 -0.3 -0.8 -1.6 -0.7 -1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.1 0.2 -0.0 -1.0 -1.0 -0.2 -0.7
Pulse rate 1.4 2.3 6.7 -0.1 -0.2 2.6 1.4 1.6 1.5
Happiness 0.7 0.8 2.8 1.7 1.1 -0.1 0.3 0.8 0.5
Noisy workplace 0.7 0.8 2.5 -0.4 -0.1 1.2 0.8 0.6 1.6
Qualifications: A levels/AS levels or equivalent 0.7 1.6 4.1 -2.0 -0.2 -0.7 -1.1 -1.2 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.5 0.7 0.8 0.2 -0.2 -0.3
Mouth/teeth dental problems: Dentures 0.2 0.3 1.3 0.0 -1.1 -0.2 -0.1 -0.2 -0.4
Asthma 1.0 2.0 4.5 -0.3 2.1 1.9 1.6 0.9 0.6
Medication: Ibuprofen (e.g. Nurofen) 3.0 3.7 7.2 -0.9 2.4 1.8 2.7 2.0 1.3
Medication: Cholesterol lowering 1.7 2.7 5.6 1.4 -1.3 2.4 1.4 1.1 1.8
Depression (self-reported) 1.2 1.4 3.5 -0.0 -0.7 -1.9 -1.8 -1.1 -0.3
Medication: Lansoprazole 0.9 1.0 4.5 0.6 -2.1 -0.1 -0.9 -0.3 0.7
Prospective memory result 2.0 2.4 4.9 0.8 -1.1 2.2 1.6 1.4 1.8
Lung cancer (father) 0.2 0.3 0.8 0.1 -0.2 -0.2 -0.9 -0.8 -0.5
Illnesses of mother 0.8 0.9 2.1 -0.1 -0.9 -1.5 -0.5 -1.1 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 3.1 0.1 -0.2 -1.5 -1.7 -0.6 -0.8
Pulse wave Arterial Stiffness index 0.9 1.0 1.6 1.2 0.3 0.9 1.3 1.2 0.9
Impedance of arm (left) 0.3 1.2 6.5 0.1 2.6 -0.5 0.3 0.5 -0.5
Arm fat mass (right) 1.7 7.1 16.1 -0.1 -4.0 -1.6 -3.3 -3.4 -1.1
Trunk predicted mass 0.3 1.8 5.4 -0.6 -2.3 -0.4 -1.8 -1.3 -0.2
Standing height 0.1 1.0 2.3 -0.9 -0.1 -1.1 -1.5 -0.7 -1.1
Length of working week for main job 5.6 6.2 11.3 -0.4 -2.7 -2.6 -2.5 -3.4 -2.3
Exposure to tobacco smoke at home 1.2 1.3 2.8 -1.7 -0.0 -1.3 -0.4 -1.4 -1.2
Breastfed as a baby 1.7 2.1 3.8 1.5 0.7 1.8 0.9 1.9 1.6
Tense / ‘highly strung’ 0.1 0.2 1.0 1.0 0.5 -0.3 -0.3 0.1 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.1 -0.4 -1.2 -1.4 -1.0 -0.8 -0.5
Hair/balding pattern: Pattern 4 0.7 1.7 2.6 0.4 0.4 1.5 1.6 1.5 1.6
Birth weight of first child 0.1 0.2 0.4 0.3 0.6 -0.3 -0.6 0.5 -0.2
Peak expiratory flow (PEF) 0.5 1.2 2.5 1.2 -0.7 -1.2 -1.6 -0.6 -1.0
Pulse wave reflection index 0.4 0.5 0.9 0.8 0.9 -0.7 0.9 -0.0 -0.1
Ever highly irritable/argumentative for 2 days 1.3 1.5 4.0 -0.3 -1.6 -1.3 -2.0 -0.8 -0.4
Loud music exposure frequency 0.7 0.7 1.7 -0.8 0.9 0.6 1.3 0.8 0.6
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.0 -1.4 0.4 1.0 0.9 1.4 0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.4 -0.7 0.9 0.4 0.7 1.0
Blood clot in the leg (DVT) 3.1 3.9 6.1 0.5 -1.9 -2.5 -2.1 -2.4 -1.9
Medication: Paracetamol 0.3 0.6 1.3 0.3 -0.7 -1.0 -1.1 -0.7 0.1
Headache pain in last month 0.5 0.9 3.1 -1.8 -0.0 0.9 0.1 0.4 1.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.0 -0.3 1.4 -1.0 -0.5 0.1 -0.5
Glaucoma (self-reported) 0.3 0.3 0.8 -0.2 -0.4 -0.1 -0.6 -0.8 -0.9
Gout (self-reported) 0.8 1.0 1.8 0.7 -1.3 -0.7 -1.3 -1.2 -0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.9 0.9 -0.6 -0.1 -0.7 0.0 0.5
Medication: Amlodipine 0.4 0.6 1.7 1.3 -0.2 -0.8 -0.5 -0.5 -0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.0 0.5 1.0 -0.3 -0.2 -0.8 -0.8
Birth weight 0.2 0.5 1.2 0.4 -1.1 1.1 0.3 0.3 0.7
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.0 -0.7 -1.0 -0.2 -0.3 -0.6 -0.3
High blood pressure (siblings) 0.3 0.5 2.2 0.2 1.5 0.3 -0.4 0.5 -0.1
Forced vital capacity (FVC), Best measure 0.2 0.6 1.4 -0.0 0.8 -1.2 -1.1 0.3 -0.4
Body fat percentage 1.5 5.9 11.9 -0.1 -3.5 -1.4 -3.0 -3.3 -1.2
Leg fat percentage (right) 2.1 7.5 19.5 -0.0 -4.4 -1.5 -3.0 -3.5 -1.2
Arm fat-free mass (right) 0.4 2.2 7.1 -0.8 -2.7 -0.2 -1.9 -1.3 0.1
Exposure to tobacco smoke outside home 0.7 0.9 1.6 1.3 -1.1 -0.1 -1.0 -1.3 -0.4
Comparative body size at age 10 0.1 0.2 0.8 0.4 -0.9 -0.2 -0.5 -0.3 -0.0
Number of full brothers 0.7 0.9 1.7 0.6 -0.8 -1.2 -1.3 -1.0 -0.7
Worry too long after embarrassment 1.4 2.3 5.2 0.9 -1.2 1.3 1.0 1.9 2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.5 1.8 0.5 -0.1 -1.3 -0.5 -0.2 -0.6
Wheeze or whistling in the chest in last year 0.4 0.7 4.1 2.0 -0.2 -0.4 -0.1 0.0 0.3
Number of children fathered 2.1 2.3 4.2 -0.5 -1.8 -1.3 -1.8 -2.0 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.3 0.7 -0.2 0.5 1.5 1.4 1.2
Age at first live birth 0.5 0.9 3.7 0.0 1.9 -1.0 0.1 -0.0 -0.8
Pulse wave peak to peak time 1.5 1.7 3.0 -1.2 -0.5 -1.3 -1.7 -1.5 -1.3
Health satisfaction 0.6 0.8 2.2 0.1 -1.2 0.8 -0.0 0.5 1.5
Shortness of breath walking on level ground 0.2 0.3 0.5 -0.7 -0.6 -0.4 -0.4 -0.6 0.3
Qualifications: College or University degree 2.9 9.2 13.9 -0.8 -1.4 -3.7 -3.5 -3.6 -3.7
Eye problems/disorders: None of the above 1.4 1.6 2.4 -0.4 1.2 1.3 1.3 1.5 1.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.0 1.0 -0.7 -0.7 0.1 0.4 0.3
Emphysema/chronic bronchitis 0.7 0.8 1.8 1.1 0.3 1.0 0.6 0.8 1.3
Medication for pain relief, constipation, heartburn 0.7 1.2 2.4 -1.4 0.6 -0.5 -1.0 -1.1 -1.5
Neck or shoulder pain in last month 0.4 0.6 2.5 -0.6 -1.6 0.5 -0.6 -0.2 0.2
Medication: Blood pressure 0.2 0.3 0.9 -0.1 -0.9 -0.2 -0.4 -0.7 -0.6
Angina (self-reported) 1.4 1.8 4.4 0.9 0.3 1.7 2.1 0.7 1.4
Migraine (self-reported) 0.5 0.6 1.5 -0.3 -1.2 -0.1 -1.1 -0.7 -0.2
Medication: Ibuprofen 1.8 2.1 3.5 -1.2 1.9 1.1 1.9 1.4 1.1
Medication: Allopurinol 1.8 2.4 4.6 1.7 -2.1 -1.0 -1.9 -1.5 -0.5
Medication: Omeprazole 0.4 0.5 1.1 1.0 -1.0 -0.0 -0.1 0.4 0.8
Medication: Seretide 50 evohaler 0.3 0.3 0.7 -0.0 -0.8 0.2 -0.6 -0.6 -0.5
Mean time to correctly identify matches 1.9 3.6 7.7 0.4 2.8 1.8 2.5 1.6 1.0
Heart disease (mother) 0.6 0.7 1.7 0.4 -1.3 -0.7 -1.0 -1.0 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.4 -0.4 0.1 0.6 -0.0 0.2 0.1
Whole body fat mass 1.5 6.2 13.5 -0.5 -3.7 -1.2 -3.2 -3.3 -1.1
Leg fat mass (right) 1.9 7.5 19.8 -0.1 -4.4 -1.3 -3.3 -3.4 -1.1
Arm predicted mass (right) 0.4 1.9 6.0 -0.4 -2.4 -0.2 -1.8 -1.4 -0.2
Pulse rate, automated reading 1.8 5.7 13.3 1.3 -0.6 3.7 2.0 2.7 2.9
Alcohol intake frequency. 0.4 0.9 3.1 1.8 -0.6 -0.6 -1.3 0.1 0.3
Comparative height size at age 10 0.0 0.2 0.4 -0.6 -0.7 0.2 -0.6 0.5 -0.0
Number of full sisters 0.3 0.4 1.2 -0.4 -1.1 0.4 -0.9 0.1 0.2
Suffer from ‘nerves’ 0.4 0.6 1.7 -0.4 -1.2 0.2 -0.2 0.5 1.3
Overall health rating 0.5 1.0 2.8 1.7 -0.8 0.2 -0.8 0.2 1.3
Chest pain or discomfort 0.6 0.9 2.9 1.7 -1.3 0.6 -0.1 -0.3 0.3
Had major operations 0.4 0.5 1.0 -0.5 1.0 0.9 1.0 0.1 0.0
Age at last live birth 0.2 0.3 1.4 0.1 1.2 -0.5 -0.1 0.3 -0.4
Family relationship satisfaction 0.3 0.3 1.1 -1.0 0.5 0.3 -0.7 -0.2 -0.0
Leg pain on walking 0.5 0.7 1.9 -0.7 -1.4 -0.6 -0.2 -1.1 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.7 0.2 0.7 1.6 0.7 1.3 1.3
Commuting to job workplace: Car/motor vehicle 0.8 1.0 1.9 0.5 -1.3 -0.8 -1.4 -1.0 -0.4
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 4.7 2.2 1.5 -0.1 1.2 1.2 0.4
Medication: Aspirin 0.8 1.1 3.3 1.2 -1.8 -0.8 -0.6 -0.7 -0.5
Supplements: Vitamin C 0.1 0.1 0.4 0.1 0.6 -0.1 0.4 0.3 0.4
Knee pain experienced in last month 0.9 1.3 1.9 -1.2 -0.8 -0.6 -1.4 -1.4 -1.4
Hypertension (Self-reported) 1.2 3.2 5.9 1.4 -2.3 -1.6 -2.4 -1.4 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 4.4 -1.6 -2.1 -1.5 -1.2 -1.6 -0.8
Illnesses of father: Heart disease 1.5 2.1 4.2 1.6 0.1 1.1 1.3 1.7 2.0
Illnesses of siblings: Diabetes 0.2 0.3 0.8 0.9 -0.5 0.3 0.4 0.3 0.7
Smoking status: Previous 0.7 1.1 2.0 -0.2 -1.4 -1.1 -1.4 -1.1 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.5 0.1 -1.2 -0.7 -1.2 -0.5 -0.1
Whole body fat-free mass 0.4 2.1 5.4 -0.4 -2.3 -0.5 -2.0 -1.6 -0.3
Leg fat-free mass (right) 0.3 1.5 3.9 -0.1 -1.8 -0.3 -2.0 -1.3 -0.1
Arm fat percentage (left) 1.5 6.1 13.6 0.1 -3.7 -1.3 -3.0 -3.3 -1.0
Average weekly red wine intake 0.7 1.0 1.7 1.3 0.1 -0.4 -1.3 -1.0 -1.3
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 -0.6 1.0 -0.8 -0.2 -0.4 -0.3
Mood swings 0.1 0.1 0.3 0.2 -0.5 -0.4 0.1 -0.2 0.3
Loneliness, isolation 1.5 2.0 3.7 -0.4 -1.0 -1.9 -1.9 -1.7 -1.0
Long-standing illness, disability or infirmity 0.2 0.3 1.1 0.7 -0.3 0.3 -0.4 0.4 1.0
Ever had bowel cancer screening 0.4 0.5 1.4 0.1 1.2 0.5 1.0 0.6 -0.5
Diabetes diagnosed by doctor 1.1 1.7 7.1 2.7 -1.5 -0.7 -0.8 -0.2 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 0.9 -0.3 -0.7 -0.5 0.1 -0.2
Friendships satisfaction 0.3 0.3 1.5 -0.5 0.3 -0.1 -1.2 -0.0 -0.2
Qualifications: nursing, teaching 0.7 1.0 2.9 1.1 -1.3 -0.2 -1.7 -0.5 -0.1
Commuting to job workplace: Walk 1.2 1.3 2.3 -1.3 -0.6 -1.0 -0.5 -1.5 -1.4
Eye problems/disorders: Cataract 2.7 3.1 5.2 1.7 -1.3 -1.4 -1.6 -2.1 -2.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.2 0.3 0.6 1.1 0.1 1.0 1.5
Medication for cholesterol 1.8 2.7 4.7 -0.2 0.6 2.2 2.2 1.6 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 3.8 1.9 -1.3 -0.2 -0.9 -0.1 0.0
Back pain experienced in last month 0.2 0.3 1.4 -1.2 -0.3 0.4 -0.1 -0.0 0.4
Mineral and other dietary supplements 0.4 0.6 1.9 1.4 1.1 -0.2 0.1 0.2 -0.3
Breast cancer (self-reported) 1.5 1.8 4.0 -0.2 1.1 1.1 1.1 1.7 2.0
Asthma (self-reported) 0.9 1.7 3.9 0.0 2.0 1.8 1.5 0.8 0.5
Osteoporosis (self-reported) 0.8 1.1 2.2 -0.4 -0.9 -1.1 -1.5 -0.9 -1.0
Osteoarthritis (self-reported) 1.2 1.5 6.2 -2.5 0.3 0.8 1.1 0.2 1.0
Medication: Aspirin 0.7 0.9 2.6 1.3 -1.6 -0.7 -0.3 -0.6 -0.1
Medication: Gliclazide 1.2 1.3 7.3 2.7 -0.2 -0.6 -0.2 -0.2 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.2 0.9 -0.9 -0.0 0.0 -0.5 -0.4 -0.3
Smoking status: Current 1.5 2.3 4.1 1.1 -1.7 -2.0 -2.0 -1.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.9 -0.4 0.9 -0.3 -0.3 0.4 0.0
Whole body water mass 0.3 1.9 5.1 -0.4 -2.3 -0.4 -1.9 -1.4 -0.2
Leg predicted mass (right) 0.3 1.5 4.0 -0.1 -1.9 -0.3 -2.0 -1.3 -0.1
Arm fat mass (left) 1.6 6.4 15.5 -0.2 -3.9 -1.4 -3.1 -3.2 -0.9
Number of self-reported non-cancer illnesses 1.3 2.3 5.1 0.2 -1.7 -1.4 -2.3 -1.6 -1.0
Average weekly champagne plus white wine intake 0.5 0.6 1.6 -0.1 0.0 1.1 1.3 1.0 0.3
Miserableness 0.1 0.1 0.3 -0.2 0.1 0.5 0.4 -0.1 0.5
Guilty feelings 0.5 0.7 1.9 0.4 -1.1 0.7 -0.4 0.7 1.4
Wears glasses or contact lenses 0.2 0.3 1.0 0.4 0.4 1.0 0.6 -0.1 0.0
Ever taken oral contraceptive pill 0.3 0.3 0.4 -0.6 -0.7 -0.4 -0.6 -0.2 -0.5
Hearing aid user 1.3 1.5 4.5 2.1 0.3 0.9 1.2 0.9 1.0
Mother’s age at death 0.8 1.0 2.1 -0.9 1.4 0.4 1.4 1.0 0.5
Financial situation satisfaction 0.1 0.1 0.5 -0.5 0.7 0.0 0.0 0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 -0.3 0.3 -0.2 0.2 -0.2 0.3
Commuting to job workplace: Public transport 0.5 0.6 2.0 -1.4 0.9 -0.1 -0.2 -0.3 -0.6
Eye problems/disorders: Glaucoma 1.0 1.2 3.3 -0.7 -0.4 -0.7 -1.0 -1.3 -1.8
Medication: Blood pressure 0.8 1.6 3.1 0.8 -1.2 -1.8 -1.6 -1.1 -0.9
Pain type(s) experienced in last month: Hip pain 0.7 0.8 3.1 0.3 -1.8 -0.9 -1.0 -0.2 -0.1
Supplements: Fish oil (including cod liver oil) 1.3 1.6 2.9 -1.5 -0.2 1.7 1.4 0.8 1.5
High cholesterol (Self-reported) 0.5 1.0 2.1 1.0 -1.4 1.2 0.2 0.5 1.0
Medication: Bendroflumethiazide 0.4 0.5 1.2 -0.1 0.1 -0.9 -0.5 -0.9 -1.1
Medication: Paracetamol 0.3 0.5 1.7 0.2 -0.6 -0.8 -1.3 -0.5 0.3
Medication: Lisinopril 2.0 2.6 5.7 -0.5 -1.9 -1.7 -2.4 -1.4 -1.1
Medication: Atorvastatin 2.9 3.5 6.8 0.3 -1.0 2.5 1.7 2.1 2.6
Illnesses of father: High blood pressure 0.9 1.1 2.5 -1.6 -0.2 -1.3 -0.9 -0.9 -1.0
Alcohol drinker status: Never 0.3 0.3 0.6 -0.3 0.7 -0.1 -0.6 -0.6 -0.8
Ever smoked 1.1 1.9 4.2 0.4 -1.8 -2.0 -1.6 -1.1 -0.5
Basal metabolic rate 0.5 2.9 7.3 -0.4 -2.7 -0.7 -2.3 -1.9 -0.5
Leg fat percentage (left) 2.3 8.2 19.4 0.1 -4.4 -1.7 -3.2 -3.8 -1.5
Arm fat-free mass (left) 0.5 2.5 7.9 -0.7 -2.8 -0.5 -1.9 -1.6 -0.3
Number of operations (self-reported) 0.8 1.2 3.1 -0.3 -0.6 -1.0 -1.7 -1.3 -1.1
Average weekly beer plus cider intake 0.6 0.9 1.4 -1.1 -0.7 -1.0 -1.2 -0.9 -0.3
Irritability 1.7 2.8 4.5 -2.0 -0.3 -2.1 -1.5 -1.5 -1.9
Risk taking 0.5 0.7 1.4 -1.2 0.2 -0.9 -0.8 -0.7 -0.8
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.0 0.9 -1.4 -0.8 -1.1 -1.4 -0.8
Fractured/broken bones in last 5 years 1.0 1.3 2.7 1.6 1.6 -0.4 -0.3 -0.4 -1.4
Age started oral contraceptive pill 1.6 1.9 4.0 -0.5 0.2 -1.7 -0.7 -2.0 -2.0
Diastolic blood pressure, automated reading 0.4 1.3 3.6 1.9 -1.6 -0.2 -1.3 0.3 -0.3
Ever depressed for a whole week 1.0 1.2 1.7 -0.7 1.2 1.1 1.2 1.3 1.1
Unable to work because of sickness or disability 0.4 0.6 1.8 1.3 -0.7 -0.0 -0.7 -0.5 0.7
Commuting to job workplace: Cycle 0.4 0.4 1.0 -1.0 0.4 -1.0 -0.2 -0.3 -0.5
Myopia 0.4 0.6 2.9 0.6 1.7 -0.1 -0.1 -0.1 -0.5
Vascular/heart problems diagnosed by doctor 1.0 2.7 7.5 -1.9 2.7 0.9 1.8 1.1 0.7
Cholesterol lowering medication 0.3 0.5 1.0 0.9 -0.9 -0.3 -1.0 -0.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.7 0.8 -1.3 -0.2 -0.3 0.3 0.8
Pain experienced in last month 0.3 0.5 2.3 0.5 1.5 -0.6 -0.1 0.1 -0.3
Supplements: Calcium 1.3 1.4 4.1 -0.0 -2.0 -0.9 -1.7 -0.9 -0.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 -0.8 0.7 -0.0 -0.1 -0.3 -0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 0.4 -0.6 0.6 0.6 0.3 0.4
Deep venous thrombosis (DVT) (self-reported) 3.6 4.6 6.8 0.5 -2.0 -2.6 -2.4 -2.5 -2.1
Heart disease (siblings) 0.2 0.3 0.9 0.6 -1.0 -0.2 -0.6 0.0 -0.4
Alcohol drinker status: Previous 0.2 0.2 0.6 -0.1 -0.1 0.2 -0.6 0.7 0.8
Pack years of smoking 0.9 1.4 5.7 2.4 -0.9 -0.2 0.0 0.7 1.1
Impedance of whole body 0.2 1.0 4.3 0.2 2.1 -0.7 0.3 0.6 -0.7
Leg fat mass (left) 2.0 7.6 18.4 -0.1 -4.3 -1.5 -3.4 -3.5 -1.2
Arm predicted mass (left) 0.6 2.9 9.0 -0.4 -3.0 -0.7 -2.1 -1.8 -0.4