Hub : Genes

KCNK6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1210	0.0480	4.8e-03	0.010	NA	0.017	NA	0.014	5.1e-02	NA	1.8e-02	NA	2.8e-02
2	GTEx	Colon Transverse	0.2090	0.0750	1.1e-03	-0.001	NA	-0.001	NA	0.006	3.6e-01	NA	3.8e-01	NA	1.5e-01
3	GTEx	Spleen	0.1730	0.0680	4.8e-03	-0.005	NA	-0.012	NA	-0.006	4.5e-01	NA	9.8e-01	NA	5.0e-01
4	GTEx	Testis	0.4070	0.0900	1.3e-06	0.165	NA	0.104	NA	0.118	8.4e-08	NA	2.3e-05	NA	6.7e-06
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0336	0.0206	5.9e-04	0.021	0.02	0.016	NA	0.022	1.7e-03	0.00250	6.2e-03	NA	1.5e-03
6	TCGA	Pheochromocytoma and Paraganglioma	0.0690	0.0400	2.1e-03	0.045	0.07	0.067	NA	0.056	6.8e-03	0.00094	1.3e-03	NA	3.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.1	3.6	-1.2	0.2	-1.4	-1.6	-1.7	-1.9
Bipolar Disorder or Schizophrenia	1.7	4.1	6.4	0.5	-0.2	-2.5	-2.5	-2.3	-2.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.8	1.4	-0.0	0.4	0.5	0.3	0.8
Depression (Nagel 2018)	0.1	0.2	0.7	-0.1	-0.1	0.1	-0.8	-0.4	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.5	-1.6	0.7	0.8	0.5	0.9	-0.2
Neuroticism (Nagel 2018)	0.6	1.3	3.3	1.0	-0.4	1.0	0.6	1.4	1.8
Schizophrenia (2018)	1.3	2.8	4.6	1.6	-0.3	-2.1	-1.9	-1.6	-1.7
Schizophrenia vs Biploar Disorder	0.6	0.8	3.6	1.9	-0.3	0.5	0.2	0.5	0.8
Worry (Nagel 2018)	1.2	2.6	5.5	1.1	-0.1	1.5	1.5	2.1	2.3
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	-0.6	1.5	0.6	0.4	1.1	0.1
Alzheimer’s Disease (in father)	0.6	0.7	1.4	0.4	-0.1	0.9	1.2	0.7	1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.4	0.8	0.6	0.5	0.7	-0.1
Crohns Disease (2017)	0.4	0.8	2.2	-0.4	1.5	-1.3	-0.4	-0.2	-0.9
Irritable Bowel Disease (IBD)	1.2	2.9	7.6	1.1	-0.1	-2.8	-1.9	-1.2	-1.8
Ulcerative Colitis (UC)	1.3	2.5	4.7	1.4	-1.0	-2.2	-2.1	-1.0	-1.3
Major Depression (MDD)	0.6	0.8	1.7	1.0	-0.1	-1.3	-1.1	-0.4	-0.9
Reaction Time	1.3	2.6	5.3	0.4	2.3	1.5	2.1	1.4	1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	-0.3	-0.5	-1.1	-1.2	-0.6	-1.3
Breast Cancer	0.1	0.2	0.4	-0.3	-0.6	-0.5	0.1	-0.5	-0.2
Ovarian Cancer	0.3	0.4	0.9	-1.0	0.2	-0.5	-0.9	-0.2	-0.7
Prostate Cancer	2.3	3.2	12.3	-0.6	0.2	-3.5	-2.6	0.0	0.0
Age at First Birth	0.2	0.3	1.3	0.2	1.1	0.3	0.7	0.2	0.2
Bipolar Disorder (2011)	0.2	0.2	1.2	0.3	1.1	-0.2	0.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	1.1	0.1	-0.5	-0.8	-0.9	-1.1
Coronary Artery Disease (CAD)	0.6	0.7	1.1	0.8	-1.0	0.5	0.7	1.1	0.9
Crohns Disease (2012)	0.4	0.7	1.4	0.6	0.8	-1.2	-0.6	-0.3	-1.1
Mean Putamen Volume	1.4	1.7	2.9	-1.5	1.6	1.7	0.7	1.0	0.7
Fasting Glucose	1.9	2.3	4.2	-0.1	2.0	1.9	1.1	1.6	1.4
HbA1C	0.7	0.8	1.6	1.0	-1.3	-0.7	-0.9	-0.7	-0.2
HDL Cholesterol	0.2	0.3	1.6	0.4	1.3	-0.0	0.3	0.3	0.2
LDL Cholesterol	0.2	0.3	1.5	0.5	1.2	-0.1	0.3	0.3	-0.0
Lupus	0.3	0.4	1.5	1.2	-0.7	-0.4	0.3	-0.6	-0.1
Neuroticism (2016)	1.0	1.4	4.4	2.1	-0.2	0.6	1.0	0.9	1.4
Primary Biliary Cirrhosis	0.4	0.6	1.7	-0.7	-0.6	-0.2	-1.3	-0.7	-0.6
Rheumatoid Arthritis	0.2	0.3	0.6	0.8	-0.3	-0.7	0.1	-0.5	-0.7
Schizophrenia (2014)	1.1	2.4	3.5	1.6	-0.7	-1.7	-1.9	-1.7	-1.5
Triglycerides	0.1	0.2	0.7	-0.3	0.0	0.8	0.0	0.3	0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.2	0.5	0.2	-0.0	-0.2	-0.2	0.0
Ulcerative Colitis	2.5	3.7	5.1	2.2	-2.2	-2.2	-2.0	-1.4	-1.1
Blood Eosinophil Count	0.8	6.0	16.8	4.1	-1.9	2.1	-1.4	1.9	2.4
Blood Platelet Count	7.6	87.7	163.8	1.9	3.8	12.8	10.6	10.1	11.4
Blood Red Count	0.1	0.8	2.0	0.1	-0.8	-1.4	0.0	-1.0	-1.0
Blood White Count	0.1	0.8	2.4	1.5	-0.9	-0.8	-0.4	0.0	0.9
Heel T-Score	0.2	1.7	4.2	0.5	-1.1	-2.0	-0.9	-1.4	-1.2
BMI	1.1	6.5	21.6	0.5	-4.7	-1.3	-2.9	-2.6	-0.1
Height	0.1	1.1	2.7	-1.2	1.1	-0.6	-1.6	0.3	-0.9
Waist Hip Ratio (WHR)	0.7	2.9	7.9	-0.2	-1.4	-2.8	-1.8	-1.7	-1.3
Systolic Blood Pressure	0.7	3.5	5.7	2.4	-1.2	-2.2	-2.2	-0.9	-1.9
Smoking Status	2.0	4.7	7.8	1.2	-2.8	-2.6	-2.6	-2.1	-1.0
Allergy or Eczema	0.6	1.7	3.4	1.2	0.7	1.6	1.0	1.9	1.1
Cardiovascular Disease	0.9	3.0	6.6	2.4	-2.6	-0.9	-1.9	-1.0	-0.5
Hypothyroidism (self reported)	0.1	0.3	1.0	0.5	-0.6	0.4	-0.3	0.4	1.0
Respiratory disease	0.5	1.0	2.6	0.7	1.6	1.5	0.7	0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.8	2.2	-0.8	-0.3	-0.4	0.1	0.1
Lung FEV1/FVC ratio	0.1	0.7	2.0	1.3	-0.4	1.4	0.1	-0.4	0.4
Lung FVC	0.1	0.3	0.6	-0.4	0.2	-0.8	0.3	0.7	0.3
Neuroticism	1.1	2.6	6.2	1.3	-1.1	1.3	1.0	2.0	2.5
Chronotype (morning person)	0.4	0.8	2.9	0.0	1.2	0.6	1.7	0.4	-0.2
Hair Pigment	0.0	0.5	1.3	1.2	-0.5	-0.3	-0.7	0.2	1.0
Tanning	0.1	1.2	4.1	-2.0	1.2	0.3	1.1	0.5	0.3
Hand grip strength (left)	0.1	0.3	0.5	-0.7	-0.7	0.6	-0.3	0.4	0.0
Number of treatments/medications taken	0.7	1.3	4.3	0.1	-2.1	-0.5	-1.7	-0.7	0.1
Average weekly spirits intake	0.1	0.1	0.4	0.1	0.3	0.3	-0.3	0.7	0.2
Sensitivity / hurt feelings	1.5	2.5	3.7	1.6	-1.9	1.7	1.2	1.1	1.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	-0.5	-0.6	-0.5	-1.2	-1.4	-0.8
Hearing difficulty/problems: Yes	0.3	0.4	0.8	0.3	-0.7	-0.6	-0.8	-0.9	-0.4
Relative age of first facial hair	0.0	0.0	0.1	-0.0	0.1	0.0	0.1	-0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	0.8	-0.3	-0.7	-1.3	-1.1	-0.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.6	0.3	-1.0	-1.9	-1.7	-1.5	-1.6
Ever had hysterectomy (womb removed)	2.4	2.7	4.3	1.3	-1.0	-2.1	-1.9	-1.3	-2.1
Systolic blood pressure, automated reading	0.9	2.6	5.5	1.0	-1.2	-1.9	-2.3	-1.0	-1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.4	1.6	-0.7	1.0	-0.0	1.0	1.5
Angina	1.1	1.4	3.8	0.6	0.4	1.6	1.9	0.5	1.2
Medication for hormone replacement therapy	0.0	0.0	0.0	0.1	0.1	0.0	-0.2	0.0	-0.0
Vitamin and mineral supplements	0.3	0.3	1.3	1.1	-0.1	0.2	-0.8	-0.0	-0.4
Supplements: Zinc	0.2	0.2	0.5	0.2	-0.3	-0.6	-0.2	0.5	0.7
Medication: Co-codamol	2.5	2.9	5.2	0.2	-2.3	-1.7	-2.2	-2.0	-0.9
Medication: Metformin	0.6	0.9	4.6	2.2	0.1	0.1	0.1	0.7	0.6
Diabetes (father)	0.9	1.2	1.9	-1.3	-0.2	-1.3	-0.4	-1.4	-1.2
Diabetes (mother)	0.4	0.5	1.1	-0.8	-0.6	-0.0	-1.1	-1.0	-0.3
Severe depression (siblings)	0.6	0.7	2.9	-1.7	0.7	-0.1	0.1	-0.8	-0.5
Pack years adult smoking proportion	0.8	1.2	4.6	2.1	-0.9	-0.3	-0.1	0.7	1.1
Impedance of leg (right)	0.1	0.3	0.7	0.1	0.7	-0.8	0.2	0.3	-0.8
Leg fat-free mass (left)	0.4	2.1	5.0	0.0	-2.2	-0.5	-2.2	-1.6	-0.3
Trunk fat percentage	1.1	4.5	8.6	0.0	-2.8	-1.3	-2.8	-2.9	-1.2
Hand grip strength (right)	0.2	0.4	1.4	-0.5	-1.2	0.4	-0.8	0.2	-0.0
Townsend deprivation index at recruitment	0.6	0.9	1.8	-0.3	-0.7	-1.0	-1.3	-1.2	-0.8
Current tobacco smoking	0.9	1.5	2.9	1.0	-1.4	-1.7	-1.7	-0.7	-0.3
Average weekly fortified wine intake	0.7	0.8	3.8	-0.1	1.9	-0.4	-0.3	-0.0	-0.7
Maternal smoking around birth	1.3	1.8	3.4	-1.0	-0.7	-1.2	-1.2	-1.7	-1.8
Fed-up feelings	0.1	0.2	0.4	0.3	-0.3	-0.5	-0.2	-0.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.4	-0.6	0.5	-0.7	-0.2	0.8
Relative age voice broke	0.1	0.2	0.6	0.5	-0.8	0.2	-0.2	0.2	0.3
Taking other prescription medications	0.7	1.1	2.6	1.6	-1.2	-0.6	-1.5	0.1	0.3
Age when periods started (menarche)	0.4	0.9	3.2	-0.0	1.8	-0.2	-0.5	-0.3	-1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.7	-1.3	-0.2	0.3	-0.2	0.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.0	0.6	1.1	1.3	0.7	1.4	1.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.2	-0.4	-1.2	-1.1	-0.8	-1.8	-1.5
Qualifications: CSEs or equivalent	0.8	1.0	2.8	0.5	-1.0	1.7	0.4	0.5	1.3
Serious illness, injury or assault to yourself	0.4	0.4	1.2	-0.1	-0.0	1.1	-0.1	0.6	1.1
High blood pressure	0.8	2.2	3.8	1.4	-1.9	-1.3	-1.9	-1.1	-1.0
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.6	0.9	1.3	1.5	0.6	1.6	1.0
Multivitamins +/- minerals	1.0	1.3	2.4	-1.6	-1.3	-1.5	-0.5	-1.0	-0.5
Stomach or abdominal pain in last month	0.5	0.7	1.8	-0.8	-1.4	-0.4	-0.8	-0.6	-0.6
Supplements: Glucosamine	0.3	0.4	0.5	-0.6	-0.6	0.7	0.7	0.5	0.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.4	0.7	-0.0	-1.4	-0.7	-1.1	-2.1
Medication: Atenolol	2.0	2.5	4.4	-0.0	0.2	1.9	1.7	2.0	2.1
Medication: Levothyroxine sodium	0.1	0.1	0.4	0.6	0.0	-0.2	-0.2	0.1	0.4
Sitting height	0.2	1.1	1.9	-0.5	0.5	-1.1	-1.4	-1.1	-1.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.5	0.5	-0.4	-0.2	-0.3	-0.4
High blood pressure (mother)	0.2	0.3	0.9	0.9	0.3	0.0	-0.9	0.2	0.3
Body mass index (BMI)	1.3	5.4	15.2	-0.1	-3.9	-0.9	-2.7	-2.9	-0.6
Impedance of leg (left)	0.1	0.3	0.7	-0.0	0.8	-0.8	0.2	0.4	-0.7
Leg predicted mass (left)	0.4	1.9	4.6	-0.0	-2.1	-0.4	-2.1	-1.5	-0.1
Trunk fat mass	1.6	6.7	12.3	-0.2	-3.5	-1.6	-3.4	-3.4	-1.5
Waist circumference	1.9	6.8	12.5	-0.7	-3.5	-1.9	-3.2	-3.4	-1.5
Number of incorrect matches in round	1.6	2.7	5.6	2.4	1.7	1.4	1.5	1.7	0.9
Past tobacco smoking	1.5	2.8	4.7	-0.2	1.9	2.1	2.2	1.8	1.1
Alcohol usually taken with meals	0.9	1.4	3.7	0.3	1.9	1.5	1.2	0.8	0.4
Nervous feelings	2.0	3.7	8.1	0.5	0.5	2.1	1.8	2.4	2.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.5	0.3	-1.2	-0.7	-0.9	-0.9	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.5	0.4	0.2	0.4	0.0	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	1.3	1.2	0.3	0.7	1.3	0.5
Had menopause	0.3	0.3	0.9	0.5	1.0	0.4	0.1	0.7	0.3
Had other major operations	3.5	4.3	8.6	1.2	-2.0	-1.8	-2.9	-2.2	-2.0
Forced vital capacity (FVC)	0.1	0.5	1.4	0.0	0.2	-1.2	-1.0	0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	0.1	0.8	1.0	0.0	0.9	0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.3	-0.5	-0.0	-0.2	0.2	0.5
Qualifications: None of the above	0.1	0.2	0.9	-0.2	-1.0	-0.3	0.0	-0.4	0.1
Financial difficulties in last 2 years	0.5	0.7	2.3	-1.5	-0.8	-0.2	-0.7	0.4	0.7
Mouth/teeth dental problems	0.3	0.5	1.3	-0.4	1.2	-0.7	-0.1	-0.6	-0.7
Heart attack	0.4	0.5	0.6	0.6	-0.6	0.7	0.8	0.6	0.8
Allergy	0.5	1.2	1.9	-1.4	-1.1	-1.2	-0.4	-1.2	-0.8
Pain all over the body in last month	1.7	1.8	6.5	1.1	-2.5	-0.6	-1.4	-0.9	0.4
Diabetes (self-reported)	1.1	1.6	5.9	2.4	-1.4	-0.7	-1.1	-0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	-0.0	0.2	-0.9	-1.1	-0.6	-1.2
Medication: Ramipril	0.1	0.1	0.2	0.5	-0.3	-0.1	0.1	-0.5	-0.2
Medication: Simvastatin	0.4	0.6	1.5	1.2	-1.0	0.4	-0.2	-0.7	-0.5
Fluid intelligence score	0.3	0.6	1.6	-0.5	-0.4	-0.9	-0.9	-0.5	-1.2
Illnesses of siblings	0.1	0.2	0.6	-0.8	0.2	-0.2	0.5	0.1	0.3
Neuroticism score	0.5	1.0	2.9	0.9	-1.7	0.0	-0.2	0.6	1.3
Weight	1.2	6.0	12.2	-0.6	-3.5	-1.4	-3.2	-3.1	-1.2
Impedance of arm (right)	0.3	1.2	5.8	0.0	2.4	-0.6	0.4	0.4	-0.7
Arm fat percentage (right)	1.7	6.5	14.4	0.2	-3.8	-1.4	-3.0	-3.5	-1.2
Trunk fat-free mass	0.3	2.0	5.6	-0.6	-2.4	-0.5	-1.9	-1.4	-0.3
Hip circumference	1.1	4.6	9.9	-1.0	-2.4	-1.3	-3.1	-2.8	-1.2
Time employed in main current job	2.7	3.1	6.7	0.5	1.5	2.6	1.5	1.7	1.9
Alcohol intake versus 10 years previously	0.2	0.3	0.7	0.8	-0.4	0.0	0.8	0.3	0.7
Father’s age at death	0.2	0.2	0.5	0.3	-0.6	-0.7	-0.1	0.1	-0.5
Worrier / anxious feelings	1.3	2.5	4.7	0.5	-0.2	1.5	1.9	2.1	2.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	0.3	-0.9	0.7	0.3	-0.0	1.0
Falls in the last year	0.4	0.5	1.6	0.0	-1.1	0.4	0.4	0.2	1.3
Hair/balding pattern: Pattern 3	0.4	0.7	2.4	-0.0	-0.1	1.5	0.6	0.5	1.0
Number of live births	0.6	0.8	2.4	-0.4	-0.3	-0.8	-1.6	-0.7	-1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	0.2	-0.0	-1.0	-1.0	-0.2	-0.7
Pulse rate	1.4	2.3	6.7	-0.1	-0.2	2.6	1.4	1.6	1.5
Happiness	0.7	0.8	2.8	1.7	1.1	-0.1	0.3	0.8	0.5
Noisy workplace	0.7	0.8	2.5	-0.4	-0.1	1.2	0.8	0.6	1.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.1	-2.0	-0.2	-0.7	-1.1	-1.2	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.5	0.7	0.8	0.2	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	1.3	0.0	-1.1	-0.2	-0.1	-0.2	-0.4
Asthma	1.0	2.0	4.5	-0.3	2.1	1.9	1.6	0.9	0.6
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.7	7.2	-0.9	2.4	1.8	2.7	2.0	1.3
Medication: Cholesterol lowering	1.7	2.7	5.6	1.4	-1.3	2.4	1.4	1.1	1.8
Depression (self-reported)	1.2	1.4	3.5	-0.0	-0.7	-1.9	-1.8	-1.1	-0.3
Medication: Lansoprazole	0.9	1.0	4.5	0.6	-2.1	-0.1	-0.9	-0.3	0.7
Prospective memory result	2.0	2.4	4.9	0.8	-1.1	2.2	1.6	1.4	1.8
Lung cancer (father)	0.2	0.3	0.8	0.1	-0.2	-0.2	-0.9	-0.8	-0.5
Illnesses of mother	0.8	0.9	2.1	-0.1	-0.9	-1.5	-0.5	-1.1	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.1	0.1	-0.2	-1.5	-1.7	-0.6	-0.8
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	1.2	0.3	0.9	1.3	1.2	0.9
Impedance of arm (left)	0.3	1.2	6.5	0.1	2.6	-0.5	0.3	0.5	-0.5
Arm fat mass (right)	1.7	7.1	16.1	-0.1	-4.0	-1.6	-3.3	-3.4	-1.1
Trunk predicted mass	0.3	1.8	5.4	-0.6	-2.3	-0.4	-1.8	-1.3	-0.2
Standing height	0.1	1.0	2.3	-0.9	-0.1	-1.1	-1.5	-0.7	-1.1
Length of working week for main job	5.6	6.2	11.3	-0.4	-2.7	-2.6	-2.5	-3.4	-2.3
Exposure to tobacco smoke at home	1.2	1.3	2.8	-1.7	-0.0	-1.3	-0.4	-1.4	-1.2
Breastfed as a baby	1.7	2.1	3.8	1.5	0.7	1.8	0.9	1.9	1.6
Tense / ‘highly strung’	0.1	0.2	1.0	1.0	0.5	-0.3	-0.3	0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.1	-0.4	-1.2	-1.4	-1.0	-0.8	-0.5
Hair/balding pattern: Pattern 4	0.7	1.7	2.6	0.4	0.4	1.5	1.6	1.5	1.6
Birth weight of first child	0.1	0.2	0.4	0.3	0.6	-0.3	-0.6	0.5	-0.2
Peak expiratory flow (PEF)	0.5	1.2	2.5	1.2	-0.7	-1.2	-1.6	-0.6	-1.0
Pulse wave reflection index	0.4	0.5	0.9	0.8	0.9	-0.7	0.9	-0.0	-0.1
Ever highly irritable/argumentative for 2 days	1.3	1.5	4.0	-0.3	-1.6	-1.3	-2.0	-0.8	-0.4
Loud music exposure frequency	0.7	0.7	1.7	-0.8	0.9	0.6	1.3	0.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-1.4	0.4	1.0	0.9	1.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.4	-0.7	0.9	0.4	0.7	1.0
Blood clot in the leg (DVT)	3.1	3.9	6.1	0.5	-1.9	-2.5	-2.1	-2.4	-1.9
Medication: Paracetamol	0.3	0.6	1.3	0.3	-0.7	-1.0	-1.1	-0.7	0.1
Headache pain in last month	0.5	0.9	3.1	-1.8	-0.0	0.9	0.1	0.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	-0.3	1.4	-1.0	-0.5	0.1	-0.5
Glaucoma (self-reported)	0.3	0.3	0.8	-0.2	-0.4	-0.1	-0.6	-0.8	-0.9
Gout (self-reported)	0.8	1.0	1.8	0.7	-1.3	-0.7	-1.3	-1.2	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	0.9	-0.6	-0.1	-0.7	0.0	0.5
Medication: Amlodipine	0.4	0.6	1.7	1.3	-0.2	-0.8	-0.5	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	0.5	1.0	-0.3	-0.2	-0.8	-0.8
Birth weight	0.2	0.5	1.2	0.4	-1.1	1.1	0.3	0.3	0.7
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	-0.7	-1.0	-0.2	-0.3	-0.6	-0.3
High blood pressure (siblings)	0.3	0.5	2.2	0.2	1.5	0.3	-0.4	0.5	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.4	-0.0	0.8	-1.2	-1.1	0.3	-0.4
Body fat percentage	1.5	5.9	11.9	-0.1	-3.5	-1.4	-3.0	-3.3	-1.2
Leg fat percentage (right)	2.1	7.5	19.5	-0.0	-4.4	-1.5	-3.0	-3.5	-1.2
Arm fat-free mass (right)	0.4	2.2	7.1	-0.8	-2.7	-0.2	-1.9	-1.3	0.1
Exposure to tobacco smoke outside home	0.7	0.9	1.6	1.3	-1.1	-0.1	-1.0	-1.3	-0.4
Comparative body size at age 10	0.1	0.2	0.8	0.4	-0.9	-0.2	-0.5	-0.3	-0.0
Number of full brothers	0.7	0.9	1.7	0.6	-0.8	-1.2	-1.3	-1.0	-0.7
Worry too long after embarrassment	1.4	2.3	5.2	0.9	-1.2	1.3	1.0	1.9	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	1.8	0.5	-0.1	-1.3	-0.5	-0.2	-0.6
Wheeze or whistling in the chest in last year	0.4	0.7	4.1	2.0	-0.2	-0.4	-0.1	0.0	0.3
Number of children fathered	2.1	2.3	4.2	-0.5	-1.8	-1.3	-1.8	-2.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.3	0.7	-0.2	0.5	1.5	1.4	1.2
Age at first live birth	0.5	0.9	3.7	0.0	1.9	-1.0	0.1	-0.0	-0.8
Pulse wave peak to peak time	1.5	1.7	3.0	-1.2	-0.5	-1.3	-1.7	-1.5	-1.3
Health satisfaction	0.6	0.8	2.2	0.1	-1.2	0.8	-0.0	0.5	1.5
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.7	-0.6	-0.4	-0.4	-0.6	0.3
Qualifications: College or University degree	2.9	9.2	13.9	-0.8	-1.4	-3.7	-3.5	-3.6	-3.7
Eye problems/disorders: None of the above	1.4	1.6	2.4	-0.4	1.2	1.3	1.3	1.5	1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	1.0	-0.7	-0.7	0.1	0.4	0.3
Emphysema/chronic bronchitis	0.7	0.8	1.8	1.1	0.3	1.0	0.6	0.8	1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	2.4	-1.4	0.6	-0.5	-1.0	-1.1	-1.5
Neck or shoulder pain in last month	0.4	0.6	2.5	-0.6	-1.6	0.5	-0.6	-0.2	0.2
Medication: Blood pressure	0.2	0.3	0.9	-0.1	-0.9	-0.2	-0.4	-0.7	-0.6
Angina (self-reported)	1.4	1.8	4.4	0.9	0.3	1.7	2.1	0.7	1.4
Migraine (self-reported)	0.5	0.6	1.5	-0.3	-1.2	-0.1	-1.1	-0.7	-0.2
Medication: Ibuprofen	1.8	2.1	3.5	-1.2	1.9	1.1	1.9	1.4	1.1
Medication: Allopurinol	1.8	2.4	4.6	1.7	-2.1	-1.0	-1.9	-1.5	-0.5
Medication: Omeprazole	0.4	0.5	1.1	1.0	-1.0	-0.0	-0.1	0.4	0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.0	-0.8	0.2	-0.6	-0.6	-0.5
Mean time to correctly identify matches	1.9	3.6	7.7	0.4	2.8	1.8	2.5	1.6	1.0
Heart disease (mother)	0.6	0.7	1.7	0.4	-1.3	-0.7	-1.0	-1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.4	0.1	0.6	-0.0	0.2	0.1
Whole body fat mass	1.5	6.2	13.5	-0.5	-3.7	-1.2	-3.2	-3.3	-1.1
Leg fat mass (right)	1.9	7.5	19.8	-0.1	-4.4	-1.3	-3.3	-3.4	-1.1
Arm predicted mass (right)	0.4	1.9	6.0	-0.4	-2.4	-0.2	-1.8	-1.4	-0.2
Pulse rate, automated reading	1.8	5.7	13.3	1.3	-0.6	3.7	2.0	2.7	2.9
Alcohol intake frequency.	0.4	0.9	3.1	1.8	-0.6	-0.6	-1.3	0.1	0.3
Comparative height size at age 10	0.0	0.2	0.4	-0.6	-0.7	0.2	-0.6	0.5	-0.0
Number of full sisters	0.3	0.4	1.2	-0.4	-1.1	0.4	-0.9	0.1	0.2
Suffer from ‘nerves’	0.4	0.6	1.7	-0.4	-1.2	0.2	-0.2	0.5	1.3
Overall health rating	0.5	1.0	2.8	1.7	-0.8	0.2	-0.8	0.2	1.3
Chest pain or discomfort	0.6	0.9	2.9	1.7	-1.3	0.6	-0.1	-0.3	0.3
Had major operations	0.4	0.5	1.0	-0.5	1.0	0.9	1.0	0.1	0.0
Age at last live birth	0.2	0.3	1.4	0.1	1.2	-0.5	-0.1	0.3	-0.4
Family relationship satisfaction	0.3	0.3	1.1	-1.0	0.5	0.3	-0.7	-0.2	-0.0
Leg pain on walking	0.5	0.7	1.9	-0.7	-1.4	-0.6	-0.2	-1.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.7	0.2	0.7	1.6	0.7	1.3	1.3
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.9	0.5	-1.3	-0.8	-1.4	-1.0	-0.4
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.7	2.2	1.5	-0.1	1.2	1.2	0.4
Medication: Aspirin	0.8	1.1	3.3	1.2	-1.8	-0.8	-0.6	-0.7	-0.5
Supplements: Vitamin C	0.1	0.1	0.4	0.1	0.6	-0.1	0.4	0.3	0.4
Knee pain experienced in last month	0.9	1.3	1.9	-1.2	-0.8	-0.6	-1.4	-1.4	-1.4
Hypertension (Self-reported)	1.2	3.2	5.9	1.4	-2.3	-1.6	-2.4	-1.4	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	4.4	-1.6	-2.1	-1.5	-1.2	-1.6	-0.8
Illnesses of father: Heart disease	1.5	2.1	4.2	1.6	0.1	1.1	1.3	1.7	2.0
Illnesses of siblings: Diabetes	0.2	0.3	0.8	0.9	-0.5	0.3	0.4	0.3	0.7
Smoking status: Previous	0.7	1.1	2.0	-0.2	-1.4	-1.1	-1.4	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.5	0.1	-1.2	-0.7	-1.2	-0.5	-0.1
Whole body fat-free mass	0.4	2.1	5.4	-0.4	-2.3	-0.5	-2.0	-1.6	-0.3
Leg fat-free mass (right)	0.3	1.5	3.9	-0.1	-1.8	-0.3	-2.0	-1.3	-0.1
Arm fat percentage (left)	1.5	6.1	13.6	0.1	-3.7	-1.3	-3.0	-3.3	-1.0
Average weekly red wine intake	0.7	1.0	1.7	1.3	0.1	-0.4	-1.3	-1.0	-1.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.6	1.0	-0.8	-0.2	-0.4	-0.3
Mood swings	0.1	0.1	0.3	0.2	-0.5	-0.4	0.1	-0.2	0.3
Loneliness, isolation	1.5	2.0	3.7	-0.4	-1.0	-1.9	-1.9	-1.7	-1.0
Long-standing illness, disability or infirmity	0.2	0.3	1.1	0.7	-0.3	0.3	-0.4	0.4	1.0
Ever had bowel cancer screening	0.4	0.5	1.4	0.1	1.2	0.5	1.0	0.6	-0.5
Diabetes diagnosed by doctor	1.1	1.7	7.1	2.7	-1.5	-0.7	-0.8	-0.2	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.9	-0.3	-0.7	-0.5	0.1	-0.2
Friendships satisfaction	0.3	0.3	1.5	-0.5	0.3	-0.1	-1.2	-0.0	-0.2
Qualifications: nursing, teaching	0.7	1.0	2.9	1.1	-1.3	-0.2	-1.7	-0.5	-0.1
Commuting to job workplace: Walk	1.2	1.3	2.3	-1.3	-0.6	-1.0	-0.5	-1.5	-1.4
Eye problems/disorders: Cataract	2.7	3.1	5.2	1.7	-1.3	-1.4	-1.6	-2.1	-2.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.2	0.3	0.6	1.1	0.1	1.0	1.5
Medication for cholesterol	1.8	2.7	4.7	-0.2	0.6	2.2	2.2	1.6	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.8	1.9	-1.3	-0.2	-0.9	-0.1	0.0
Back pain experienced in last month	0.2	0.3	1.4	-1.2	-0.3	0.4	-0.1	-0.0	0.4
Mineral and other dietary supplements	0.4	0.6	1.9	1.4	1.1	-0.2	0.1	0.2	-0.3
Breast cancer (self-reported)	1.5	1.8	4.0	-0.2	1.1	1.1	1.1	1.7	2.0
Asthma (self-reported)	0.9	1.7	3.9	0.0	2.0	1.8	1.5	0.8	0.5
Osteoporosis (self-reported)	0.8	1.1	2.2	-0.4	-0.9	-1.1	-1.5	-0.9	-1.0
Osteoarthritis (self-reported)	1.2	1.5	6.2	-2.5	0.3	0.8	1.1	0.2	1.0
Medication: Aspirin	0.7	0.9	2.6	1.3	-1.6	-0.7	-0.3	-0.6	-0.1
Medication: Gliclazide	1.2	1.3	7.3	2.7	-0.2	-0.6	-0.2	-0.2	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.9	-0.0	0.0	-0.5	-0.4	-0.3
Smoking status: Current	1.5	2.3	4.1	1.1	-1.7	-2.0	-2.0	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.9	-0.4	0.9	-0.3	-0.3	0.4	0.0
Whole body water mass	0.3	1.9	5.1	-0.4	-2.3	-0.4	-1.9	-1.4	-0.2
Leg predicted mass (right)	0.3	1.5	4.0	-0.1	-1.9	-0.3	-2.0	-1.3	-0.1
Arm fat mass (left)	1.6	6.4	15.5	-0.2	-3.9	-1.4	-3.1	-3.2	-0.9
Number of self-reported non-cancer illnesses	1.3	2.3	5.1	0.2	-1.7	-1.4	-2.3	-1.6	-1.0
Average weekly champagne plus white wine intake	0.5	0.6	1.6	-0.1	0.0	1.1	1.3	1.0	0.3
Miserableness	0.1	0.1	0.3	-0.2	0.1	0.5	0.4	-0.1	0.5
Guilty feelings	0.5	0.7	1.9	0.4	-1.1	0.7	-0.4	0.7	1.4
Wears glasses or contact lenses	0.2	0.3	1.0	0.4	0.4	1.0	0.6	-0.1	0.0
Ever taken oral contraceptive pill	0.3	0.3	0.4	-0.6	-0.7	-0.4	-0.6	-0.2	-0.5
Hearing aid user	1.3	1.5	4.5	2.1	0.3	0.9	1.2	0.9	1.0
Mother’s age at death	0.8	1.0	2.1	-0.9	1.4	0.4	1.4	1.0	0.5
Financial situation satisfaction	0.1	0.1	0.5	-0.5	0.7	0.0	0.0	0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.3	0.3	-0.2	0.2	-0.2	0.3
Commuting to job workplace: Public transport	0.5	0.6	2.0	-1.4	0.9	-0.1	-0.2	-0.3	-0.6
Eye problems/disorders: Glaucoma	1.0	1.2	3.3	-0.7	-0.4	-0.7	-1.0	-1.3	-1.8
Medication: Blood pressure	0.8	1.6	3.1	0.8	-1.2	-1.8	-1.6	-1.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.1	0.3	-1.8	-0.9	-1.0	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.6	2.9	-1.5	-0.2	1.7	1.4	0.8	1.5
High cholesterol (Self-reported)	0.5	1.0	2.1	1.0	-1.4	1.2	0.2	0.5	1.0
Medication: Bendroflumethiazide	0.4	0.5	1.2	-0.1	0.1	-0.9	-0.5	-0.9	-1.1
Medication: Paracetamol	0.3	0.5	1.7	0.2	-0.6	-0.8	-1.3	-0.5	0.3
Medication: Lisinopril	2.0	2.6	5.7	-0.5	-1.9	-1.7	-2.4	-1.4	-1.1
Medication: Atorvastatin	2.9	3.5	6.8	0.3	-1.0	2.5	1.7	2.1	2.6
Illnesses of father: High blood pressure	0.9	1.1	2.5	-1.6	-0.2	-1.3	-0.9	-0.9	-1.0
Alcohol drinker status: Never	0.3	0.3	0.6	-0.3	0.7	-0.1	-0.6	-0.6	-0.8
Ever smoked	1.1	1.9	4.2	0.4	-1.8	-2.0	-1.6	-1.1	-0.5
Basal metabolic rate	0.5	2.9	7.3	-0.4	-2.7	-0.7	-2.3	-1.9	-0.5
Leg fat percentage (left)	2.3	8.2	19.4	0.1	-4.4	-1.7	-3.2	-3.8	-1.5
Arm fat-free mass (left)	0.5	2.5	7.9	-0.7	-2.8	-0.5	-1.9	-1.6	-0.3
Number of operations (self-reported)	0.8	1.2	3.1	-0.3	-0.6	-1.0	-1.7	-1.3	-1.1
Average weekly beer plus cider intake	0.6	0.9	1.4	-1.1	-0.7	-1.0	-1.2	-0.9	-0.3
Irritability	1.7	2.8	4.5	-2.0	-0.3	-2.1	-1.5	-1.5	-1.9
Risk taking	0.5	0.7	1.4	-1.2	0.2	-0.9	-0.8	-0.7	-0.8
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.0	0.9	-1.4	-0.8	-1.1	-1.4	-0.8
Fractured/broken bones in last 5 years	1.0	1.3	2.7	1.6	1.6	-0.4	-0.3	-0.4	-1.4
Age started oral contraceptive pill	1.6	1.9	4.0	-0.5	0.2	-1.7	-0.7	-2.0	-2.0
Diastolic blood pressure, automated reading	0.4	1.3	3.6	1.9	-1.6	-0.2	-1.3	0.3	-0.3
Ever depressed for a whole week	1.0	1.2	1.7	-0.7	1.2	1.1	1.2	1.3	1.1
Unable to work because of sickness or disability	0.4	0.6	1.8	1.3	-0.7	-0.0	-0.7	-0.5	0.7
Commuting to job workplace: Cycle	0.4	0.4	1.0	-1.0	0.4	-1.0	-0.2	-0.3	-0.5
Myopia	0.4	0.6	2.9	0.6	1.7	-0.1	-0.1	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	1.0	2.7	7.5	-1.9	2.7	0.9	1.8	1.1	0.7
Cholesterol lowering medication	0.3	0.5	1.0	0.9	-0.9	-0.3	-1.0	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.7	0.8	-1.3	-0.2	-0.3	0.3	0.8
Pain experienced in last month	0.3	0.5	2.3	0.5	1.5	-0.6	-0.1	0.1	-0.3
Supplements: Calcium	1.3	1.4	4.1	-0.0	-2.0	-0.9	-1.7	-0.9	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.8	0.7	-0.0	-0.1	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	0.4	-0.6	0.6	0.6	0.3	0.4
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	6.8	0.5	-2.0	-2.6	-2.4	-2.5	-2.1
Heart disease (siblings)	0.2	0.3	0.9	0.6	-1.0	-0.2	-0.6	0.0	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.1	-0.1	0.2	-0.6	0.7	0.8
Pack years of smoking	0.9	1.4	5.7	2.4	-0.9	-0.2	0.0	0.7	1.1
Impedance of whole body	0.2	1.0	4.3	0.2	2.1	-0.7	0.3	0.6	-0.7
Leg fat mass (left)	2.0	7.6	18.4	-0.1	-4.3	-1.5	-3.4	-3.5	-1.2
Arm predicted mass (left)	0.6	2.9	9.0	-0.4	-3.0	-0.7	-2.1	-1.8	-0.4