Hub : Genes

KCNQ5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0249	0.0105	0.00530	0.011	0.003	0.018	0.004	0.015	0.00013	0.0430	1.1e-06	0.015	1.1e-05
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0571	0.0238	0.00290	0.015	0.014	0.002	NA	0.031	0.00800	0.0100	1.7e-01	NA	1.7e-04
3	TCGA	Prostate Adenocarcinoma	0.1039	0.0337	0.00011	-0.003	0.021	0.003	NA	-0.001	0.89000	0.0027	1.5e-01	NA	4.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.5	2.4	6.0	0.7	-2.4	0.9
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	-0.3	-0.8	0.0
Depressed Affect (Nagel 2018)	3.4	7.2	11.0	-0.9	3.1	-3.3
Depression (Nagel 2018)	1.5	2.3	4.1	-1.2	1.2	-2.0
Intelligence (Savage-Jansen 2018)	1.0	3.0	7.8	-2.8	-0.8	0.7
Neuroticism (Nagel 2018)	2.2	5.2	13.7	0.5	1.2	-3.7
Schizophrenia (2018)	0.3	0.6	0.9	-0.7	0.9	-0.7
Schizophrenia vs Biploar Disorder	2.8	3.7	5.4	-2.3	2.3	-0.7
Worry (Nagel 2018)	1.4	3.0	6.6	1.5	-0.2	-2.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.4	0.3	-1.0
Alzheimer’s Disease (in father)	0.9	1.0	1.8	-1.0	1.3	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	0.0	1.4	-0.8
Crohns Disease (2017)	0.9	1.9	4.2	2.0	0.8	-0.9
Irritable Bowel Disease (IBD)	0.8	1.9	5.6	2.4	0.3	-0.2
Ulcerative Colitis (UC)	0.5	0.9	2.6	1.6	-0.1	-0.0
Major Depression (MDD)	0.4	0.5	0.8	0.4	0.7	-0.9
Reaction Time	0.3	0.6	1.2	1.1	-0.4	0.7
Verbal and Numeric Reasoning (VNR)	1.0	2.5	7.1	-2.7	-0.5	-0.1
Breast Cancer	1.4	3.4	8.9	0.6	-3.0	1.0
Ovarian Cancer	0.7	0.9	1.5	-0.8	0.8	-1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.5	1.1	1.0	-0.1	0.7
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.2	0.0	-0.3
Body Mass Index (BMI) (2010)	0.3	0.5	1.2	1.1	-0.3	-0.2
Coronary Artery Disease (CAD)	1.6	1.9	2.2	1.5	-1.1	-1.5
Crohns Disease (2012)	0.3	0.5	1.2	0.3	1.1	-0.4
Mean Putamen Volume	0.2	0.2	0.3	-0.5	-0.5	0.2
Fasting Glucose	0.1	0.2	0.3	0.3	0.3	0.5
HbA1C	0.8	0.9	2.2	-0.0	-1.5	0.6
HDL Cholesterol	0.3	0.6	1.5	-0.4	-1.2	-0.2
LDL Cholesterol	0.3	0.5	0.8	0.6	0.7	-0.9
Lupus	0.4	0.7	1.0	0.3	-0.9	-1.0
Neuroticism (2016)	2.3	3.3	5.6	-0.1	2.4	-2.1
Primary Biliary Cirrhosis	2.6	3.7	6.0	-0.4	2.4	-2.2
Rheumatoid Arthritis	0.9	1.2	1.5	0.9	1.2	-1.2
Schizophrenia (2014)	0.5	1.1	1.3	-1.0	1.1	-1.1
Triglycerides	0.2	0.4	0.6	0.4	0.8	-0.5
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.5	0.3	0.3	-2.1
Ulcerative Colitis	0.1	0.2	0.4	-0.4	0.6	0.0
Blood Eosinophil Count	0.3	2.6	4.4	1.3	2.1	-1.3
Blood Platelet Count	0.2	1.8	4.2	2.0	-1.2	0.2
Blood Red Count	0.1	1.2	3.5	0.3	-1.9	0.4
Blood White Count	0.1	0.9	2.5	1.6	-0.5	0.2
Heel T-Score	0.2	1.3	3.7	-0.1	-0.1	-1.9
BMI	0.2	1.0	2.1	0.8	0.6	-1.4
Height	0.0	0.3	0.9	0.2	-0.3	0.9
Waist Hip Ratio (WHR)	0.4	1.8	3.2	1.4	1.8	-0.6
Systolic Blood Pressure	0.3	1.4	2.3	-0.2	1.4	-1.5
Smoking Status	1.1	2.5	6.0	2.4	1.3	0.1
Allergy or Eczema	1.0	2.5	6.9	2.6	0.5	0.6
Cardiovascular Disease	1.8	5.9	8.7	-1.3	2.7	-3.0
Hypothyroidism (self reported)	1.1	2.6	4.5	0.4	1.8	-2.1
Respiratory disease	0.5	1.0	1.7	1.3	0.2	-1.1
Type 2 Diabetes (T2D) (2018)	1.1	2.1	2.7	-1.5	1.7	-1.2
Lung FEV1/FVC ratio	3.1	15.6	26.5	-2.1	4.0	-5.2
Lung FVC	2.4	12.0	27.1	-0.9	-2.9	5.2
Neuroticism	1.2	2.9	6.2	1.3	0.9	-2.5
Chronotype (morning person)	1.1	2.6	4.6	1.8	-2.2	-0.3
Hair Pigment	0.0	1.1	2.1	-0.0	1.5	-1.0
Tanning	0.1	0.8	1.2	0.8	-1.1	0.8
Hand grip strength (left)	1.2	3.3	7.5	2.7	-1.4	0.6
Number of treatments/medications taken	0.4	0.8	2.3	-0.1	0.1	-1.5
Average weekly spirits intake	0.3	0.4	1.0	0.5	0.1	1.0
Sensitivity / hurt feelings	1.2	2.1	4.5	0.7	1.1	-2.1
Frequency of depressed mood in last 2 weeks	3.4	4.7	8.6	-0.1	2.9	-2.3
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.4	0.8	-0.4
Relative age of first facial hair	0.6	1.3	3.3	1.8	0.5	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.8	0.2	-1.3	-0.2
Ever used hormone-replacement therapy (HRT)	3.1	3.9	5.9	-2.2	2.4	-1.0
Ever had hysterectomy (womb removed)	2.8	3.2	4.5	2.1	-1.1	1.9
Systolic blood pressure, automated reading	0.2	0.6	0.9	-0.9	1.0	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.3	1.1	0.8	-0.8
Angina	1.4	1.9	3.2	-0.6	1.5	-1.8
Medication for hormone replacement therapy	1.0	1.1	1.7	-1.3	0.9	-0.8
Vitamin and mineral supplements	0.4	0.6	1.0	0.8	-0.2	-1.0
Supplements: Zinc	1.4	1.5	3.5	-0.9	1.9	-0.4
Medication: Co-codamol	0.1	0.1	0.2	-0.3	-0.4	-0.4
Medication: Metformin	0.8	1.1	3.2	-0.3	-0.2	-1.8
Diabetes (father)	0.5	0.6	1.6	-0.4	0.2	-1.3
Diabetes (mother)	0.6	0.8	1.6	0.7	-0.5	1.3
Severe depression (siblings)	1.9	2.2	2.8	1.7	1.1	-1.6
Pack years adult smoking proportion	0.5	0.8	1.1	0.5	1.0	-1.0
Impedance of leg (right)	0.4	2.2	5.4	-1.0	-0.4	2.3
Leg fat-free mass (left)	0.6	3.4	6.0	1.5	1.4	-2.5
Trunk fat percentage	0.3	1.4	2.8	1.1	0.4	-1.7
Hand grip strength (right)	1.7	4.7	13.2	3.6	-0.7	0.6
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.6	0.2	-1.0
Current tobacco smoking	0.5	0.8	1.1	0.9	0.8	1.1
Average weekly fortified wine intake	3.6	4.2	6.8	1.4	-2.6	2.0
Maternal smoking around birth	1.0	1.5	2.4	1.6	0.7	-1.3
Fed-up feelings	1.3	2.4	3.9	0.6	2.0	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.4	-0.7	1.5	-0.7
Relative age voice broke	0.1	0.2	0.5	0.7	-0.1	-0.4
Taking other prescription medications	0.2	0.3	0.3	0.6	0.4	-0.6
Age when periods started (menarche)	0.1	0.2	0.7	-0.8	-0.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.7	-0.2	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	1.2	0.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.5	1.2	1.2	0.1
Qualifications: CSEs or equivalent	2.0	2.7	7.9	2.8	0.4	-0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.4	-0.2	-0.7
High blood pressure	1.1	3.0	6.7	-0.8	1.3	-2.6
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.7	2.6	1.6	-0.7
Multivitamins +/- minerals	0.8	1.1	2.2	-1.5	0.0	1.0
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.2	-0.9	0.1
Supplements: Glucosamine	0.6	0.8	1.7	-1.3	-0.3	0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.0	1.3	-0.7	1.4
Medication: Atenolol	0.8	1.0	2.2	-1.5	-0.1	0.8
Medication: Levothyroxine sodium	0.9	1.6	2.2	-0.9	1.3	-1.5
Sitting height	0.4	3.2	4.0	-1.6	1.7	-2.0
Chronic bronchitis/emphysema (father)	1.5	1.7	4.9	2.2	-0.5	0.3
High blood pressure (mother)	1.0	1.4	2.9	1.7	-1.1	-0.0
Body mass index (BMI)	0.5	2.2	4.6	1.1	0.9	-2.1
Impedance of leg (left)	0.3	1.6	4.4	-0.4	-0.5	2.1
Leg predicted mass (left)	0.6	3.4	5.8	1.6	1.3	-2.4
Trunk fat mass	0.4	1.6	3.2	1.3	0.4	-1.8
Waist circumference	0.5	1.8	2.6	1.5	0.8	-1.6
Number of incorrect matches in round	0.8	1.2	2.2	1.3	-1.5	-0.1
Past tobacco smoking	1.3	2.5	5.8	-2.4	0.2	1.2
Alcohol usually taken with meals	2.3	3.8	6.0	2.0	-2.5	1.1
Nervous feelings	1.8	3.3	6.3	1.2	1.5	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.3	-0.9	2.1	-1.3
Hearing difficulty/problems with background noise	0.4	0.6	0.7	-0.8	0.6	-0.8
Hair/balding pattern: Pattern 2	2.7	3.4	6.9	2.6	0.7	-1.7
Had menopause	0.2	0.2	0.5	0.2	-0.4	0.7
Had other major operations	0.7	0.9	2.3	-0.6	-1.5	0.2
Forced vital capacity (FVC)	0.7	2.8	7.1	-0.5	-1.0	2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	-0.2	-0.1	-0.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.1	1.3	0.4	-1.4
Qualifications: None of the above	0.1	0.1	0.3	0.5	-0.2	0.3
Financial difficulties in last 2 years	1.1	1.5	2.5	1.6	1.4	0.2
Mouth/teeth dental problems	0.9	1.4	2.6	1.0	0.7	-1.6
Heart attack	1.7	2.2	4.2	-2.1	1.0	-1.1
Allergy	1.5	3.4	5.4	-2.3	-1.9	1.1
Pain all over the body in last month	1.0	1.1	2.6	0.3	1.6	-0.7
Diabetes (self-reported)	0.3	0.4	1.2	-1.1	0.3	-0.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.0	1.7	-0.8	0.8
Medication: Ramipril	0.3	0.4	0.7	-0.2	0.8	-0.8
Medication: Simvastatin	0.4	0.5	1.6	-0.0	-0.2	-1.3
Fluid intelligence score	2.2	4.6	12.2	-3.5	-0.8	-0.9
Illnesses of siblings	1.3	1.9	3.1	1.3	-1.8	1.0
Neuroticism score	1.7	3.5	6.2	1.0	1.8	-2.5
Weight	0.4	2.0	3.7	1.4	0.7	-1.9
Impedance of arm (right)	0.1	0.6	1.6	-0.4	-0.2	1.3
Arm fat percentage (right)	0.6	2.4	5.9	0.7	0.9	-2.4
Trunk fat-free mass	0.1	0.8	1.3	1.0	0.5	-1.1
Hip circumference	0.2	0.9	2.0	0.9	-0.0	-1.4
Time employed in main current job	0.1	0.1	0.1	-0.4	-0.3	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.4	0.1	0.5
Father’s age at death	0.3	0.4	0.5	-0.7	-0.7	0.5
Worrier / anxious feelings	1.8	3.3	7.3	2.7	-1.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.3	0.8	1.0	-1.1
Falls in the last year	0.7	1.0	2.8	0.3	0.3	-1.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	-1.3	0.1	1.0
Number of live births	0.2	0.3	0.7	-0.8	0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.3	-1.1	0.2	1.1
Pulse rate	1.0	1.7	4.8	0.5	2.2	-0.0
Happiness	0.8	0.9	2.6	0.3	1.6	0.3
Noisy workplace	1.0	1.2	2.6	0.9	-1.6	0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.8	-0.1	-0.4	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.5	-0.7	0.5	0.6
Mouth/teeth dental problems: Dentures	0.7	1.1	1.8	-1.3	-0.0	1.4
Asthma	1.2	2.5	3.9	1.3	1.3	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-0.8	0.5	-1.3
Medication: Cholesterol lowering	0.7	1.2	2.0	-1.4	0.6	-1.1
Depression (self-reported)	1.2	1.4	3.2	1.0	0.2	-1.8
Medication: Lansoprazole	4.7	5.3	11.7	1.0	1.8	-3.4
Prospective memory result	0.9	1.1	2.9	1.7	-0.3	0.4
Lung cancer (father)	2.4	2.8	6.6	0.7	1.2	-2.6
Illnesses of mother	0.2	0.2	0.6	-0.8	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	0.2	-0.7	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.5	0.7	0.7	0.4
Impedance of arm (left)	0.2	0.8	1.8	-0.2	-0.6	1.4
Arm fat mass (right)	0.6	2.6	5.9	1.2	0.6	-2.4
Trunk predicted mass	0.2	0.9	1.5	0.9	0.6	-1.2
Standing height	0.0	0.2	0.6	0.7	-0.2	0.1
Length of working week for main job	0.2	0.2	0.3	-0.1	0.5	-0.5
Exposure to tobacco smoke at home	0.5	0.6	1.2	-0.3	-0.7	1.1
Breastfed as a baby	1.1	1.4	3.2	1.0	-1.8	0.3
Tense / ‘highly strung’	1.8	3.1	4.6	1.0	1.9	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.8	7.4	10.8	0.9	3.3	-3.3
Hair/balding pattern: Pattern 4	0.7	1.7	4.2	-2.0	-0.7	-0.5
Birth weight of first child	0.5	0.9	2.6	1.6	-0.3	0.4
Peak expiratory flow (PEF)	0.1	0.3	0.5	0.0	0.7	0.6
Pulse wave reflection index	1.3	1.6	2.9	1.2	-0.7	1.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.8	-0.2	-0.3
Loud music exposure frequency	1.5	1.7	2.5	-0.5	1.5	-1.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.7	1.1	-0.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.8	0.3	-1.3	1.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.8	0.2	0.4
Medication: Paracetamol	0.3	0.5	1.5	-0.3	-0.0	1.2
Headache pain in last month	2.6	4.5	8.9	-1.9	3.0	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.0	1.4	-0.7	1.0
Glaucoma (self-reported)	0.2	0.3	0.7	-0.8	-0.1	0.2
Gout (self-reported)	4.3	5.9	9.8	-1.5	2.4	-3.1
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	6.5	-0.1	2.3	-2.5
Medication: Amlodipine	0.8	1.2	2.6	-0.8	1.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	1.4	0.2	0.7
Birth weight	0.2	0.5	1.1	-1.0	0.3	0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	0.0	-0.1
High blood pressure (siblings)	0.1	0.2	0.3	-0.5	0.6	-0.3
Forced vital capacity (FVC), Best measure	0.6	2.3	4.2	0.7	-1.5	2.0
Body fat percentage	0.3	1.3	2.7	1.1	0.4	-1.6
Leg fat percentage (right)	0.1	0.5	0.8	0.9	0.3	-0.8
Arm fat-free mass (right)	0.3	1.6	2.6	1.2	0.7	-1.6
Exposure to tobacco smoke outside home	1.8	2.4	6.1	-0.7	2.5	-0.8
Comparative body size at age 10	0.1	0.2	0.7	0.8	0.1	0.1
Number of full brothers	1.3	1.6	2.6	-1.6	1.4	-0.3
Worry too long after embarrassment	1.5	2.5	5.6	1.4	0.0	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	1.9	0.9	1.4	-1.2
Wheeze or whistling in the chest in last year	0.5	0.9	1.3	1.1	0.5	-1.1
Number of children fathered	0.8	1.0	2.3	0.5	-1.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.5	1.6	-1.9	-0.4
Age at first live birth	1.7	3.0	8.2	0.5	-0.7	2.9
Pulse wave peak to peak time	0.5	0.5	0.9	-0.8	-0.9	-0.4
Health satisfaction	0.3	0.4	1.0	-0.1	-0.2	-1.0
Shortness of breath walking on level ground	0.8	0.9	1.5	1.0	-0.4	-1.2
Qualifications: College or University degree	1.0	3.2	4.5	-1.0	-2.0	2.1
Eye problems/disorders: None of the above	0.5	0.5	1.5	-0.3	1.2	0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.1	-0.7	0.2
Emphysema/chronic bronchitis	0.6	0.7	1.3	0.6	0.7	-1.1
Medication for pain relief, constipation, heartburn	1.2	2.0	5.2	2.3	-0.1	0.9
Neck or shoulder pain in last month	2.1	2.9	5.1	-0.0	1.9	-2.3
Medication: Blood pressure	1.5	2.7	4.1	-2.0	1.6	-1.1
Angina (self-reported)	2.4	3.1	4.8	-0.7	2.0	-2.2
Migraine (self-reported)	0.3	0.3	0.8	-0.3	0.3	-0.9
Medication: Ibuprofen	0.6	0.8	2.1	-0.4	-0.2	-1.4
Medication: Allopurinol	1.9	2.6	4.4	-0.9	1.6	-2.1
Medication: Omeprazole	0.3	0.4	1.2	-1.1	0.0	0.0
Medication: Seretide 50 evohaler	0.6	0.7	1.0	0.9	-0.4	1.0
Mean time to correctly identify matches	0.7	1.3	2.1	0.9	-1.5	1.0
Heart disease (mother)	0.3	0.4	0.9	-0.6	0.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.6	1.6	1.0	-1.3
Whole body fat mass	0.6	2.4	4.5	1.5	0.5	-2.1
Leg fat mass (right)	0.4	1.7	3.2	1.2	0.7	-1.8
Arm predicted mass (right)	0.3	1.3	2.2	0.9	0.9	-1.5
Pulse rate, automated reading	0.7	2.3	6.4	-0.5	2.5	-0.4
Alcohol intake frequency.	1.0	2.3	4.4	1.4	0.8	-2.1
Comparative height size at age 10	0.2	1.1	2.1	1.5	-0.4	-1.0
Number of full sisters	0.8	1.0	2.5	-0.3	1.6	-0.6
Suffer from ‘nerves’	1.8	2.8	6.4	1.0	1.1	-2.5
Overall health rating	0.3	0.7	1.0	0.5	1.0	-0.9
Chest pain or discomfort	0.2	0.3	0.5	0.7	0.3	-0.6
Had major operations	0.3	0.3	0.8	0.0	-0.9	-0.3
Age at last live birth	0.1	0.1	0.3	0.0	-0.2	0.5
Family relationship satisfaction	0.5	0.7	1.4	0.5	-1.2	0.5
Leg pain on walking	0.4	0.5	0.8	0.9	-0.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.3	1.2	1.0	-1.8
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	1.4	-1.2	-0.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	-0.8	0.7	-1.2
Medication: Aspirin	4.4	5.8	8.1	-2.8	2.1	-2.3
Supplements: Vitamin C	0.6	0.7	1.1	0.5	1.1	-0.9
Knee pain experienced in last month	2.0	3.2	5.8	-0.7	2.4	-1.8
Hypertension (Self-reported)	1.1	3.0	6.4	-0.9	1.3	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.8	1.7	-1.1	0.5
Illnesses of father: Heart disease	0.9	1.2	1.9	-0.8	1.4	-1.1
Illnesses of siblings: Diabetes	1.7	2.1	3.8	-2.0	1.6	0.1
Smoking status: Previous	0.7	1.0	2.0	1.4	0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.8	1.3	0.3	-0.1
Whole body fat-free mass	0.3	1.8	3.2	1.2	0.9	-1.8
Leg fat-free mass (right)	0.7	3.7	6.3	1.8	1.3	-2.5
Arm fat percentage (left)	0.5	2.1	5.0	0.9	0.7	-2.2
Average weekly red wine intake	1.1	1.6	2.4	1.3	-0.8	1.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.2	0.7	-0.5
Mood swings	2.2	4.0	7.0	-0.2	2.6	-2.3
Loneliness, isolation	5.9	8.1	14.0	-0.5	3.2	-3.7
Long-standing illness, disability or infirmity	0.6	0.9	1.3	-0.8	0.8	-1.1
Ever had bowel cancer screening	0.1	0.1	0.1	0.3	0.3	0.3
Diabetes diagnosed by doctor	0.4	0.6	1.1	-1.1	0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	-0.4	0.2
Friendships satisfaction	0.4	0.5	0.9	1.0	0.7	-0.5
Qualifications: nursing, teaching	0.4	0.6	1.1	-0.1	-1.0	0.8
Commuting to job workplace: Walk	4.9	5.3	6.7	-1.9	2.4	-2.6
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.6	0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.3	-1.0	0.6	-1.5
Medication for cholesterol	0.8	1.2	3.6	0.3	0.1	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.8	-0.1	-0.7
Back pain experienced in last month	0.8	1.2	2.4	-0.3	1.0	-1.6
Mineral and other dietary supplements	0.1	0.2	0.3	0.2	0.5	0.5
Breast cancer (self-reported)	0.4	0.4	1.1	-0.1	-0.4	1.1
Asthma (self-reported)	1.2	2.4	3.4	1.3	1.4	-1.8
Osteoporosis (self-reported)	0.4	0.5	0.8	-0.9	0.8	-0.1
Osteoarthritis (self-reported)	1.0	1.3	2.8	0.2	1.0	-1.7
Medication: Aspirin	3.4	4.4	6.6	-2.6	1.8	-1.9
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.4	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.1	-0.6	0.3
Smoking status: Current	0.4	0.7	1.0	1.0	0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.7	-0.9	-0.6	1.7
Whole body water mass	0.3	1.5	2.7	1.1	0.7	-1.6
Leg predicted mass (right)	0.6	3.4	5.9	1.7	1.2	-2.4
Arm fat mass (left)	0.7	2.7	6.3	1.1	0.8	-2.5
Number of self-reported non-cancer illnesses	1.1	1.9	3.1	1.8	0.7	-1.5
Average weekly champagne plus white wine intake	0.6	0.8	1.4	1.0	-0.4	-1.2
Miserableness	1.3	2.2	3.9	-1.5	2.0	-0.8
Guilty feelings	1.8	2.8	4.7	1.5	1.1	-2.2
Wears glasses or contact lenses	1.4	1.6	3.6	-0.4	-1.9	1.0
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.3	0.4
Hearing aid user	0.7	0.8	2.0	0.4	-0.4	-1.4
Mother’s age at death	0.4	0.5	0.9	0.5	-0.6	0.9
Financial situation satisfaction	2.1	2.6	7.7	2.8	-0.0	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.0	-0.0	-0.9
Commuting to job workplace: Public transport	0.7	0.8	2.2	0.1	0.5	1.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.0	-1.0	-0.8	0.7
Medication: Blood pressure	0.9	1.7	5.0	0.1	0.4	-2.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.4	-0.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	-0.7	-0.7	-1.0
High cholesterol (Self-reported)	0.9	1.6	2.3	-1.0	1.2	-1.5
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.3	0.6	-0.4
Medication: Paracetamol	0.3	0.4	1.1	-0.0	-0.4	1.1
Medication: Lisinopril	1.2	1.6	3.1	1.0	-0.8	-1.8
Medication: Atorvastatin	1.4	1.8	4.2	-2.0	0.8	-0.7
Illnesses of father: High blood pressure	1.0	1.3	3.0	1.7	-0.8	0.4
Alcohol drinker status: Never	1.4	1.7	4.2	-0.8	-0.5	-2.1
Ever smoked	1.1	2.0	4.0	2.0	-0.7	-1.2
Basal metabolic rate	0.4	2.2	3.9	1.4	0.9	-2.0
Leg fat percentage (left)	0.2	0.8	1.6	1.3	0.2	-0.9
Arm fat-free mass (left)	0.3	1.6	3.0	1.0	0.9	-1.7
Number of operations (self-reported)	0.5	0.8	1.3	0.7	-1.2	0.7
Average weekly beer plus cider intake	1.1	1.5	3.2	-0.5	1.1	-1.8
Irritability	0.5	0.8	1.5	-0.5	0.8	-1.2
Risk taking	0.3	0.4	0.8	0.1	0.7	-0.9
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.2	0.0	-2.0	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.4	-0.9	0.5
Age started oral contraceptive pill	1.5	1.9	3.6	-1.5	0.1	1.9
Diastolic blood pressure, automated reading	0.3	0.8	1.5	-0.1	1.0	1.2
Ever depressed for a whole week	0.2	0.3	0.6	0.2	0.4	-0.8
Unable to work because of sickness or disability	2.2	2.9	6.2	1.4	2.5	-0.7
Commuting to job workplace: Cycle	2.7	3.3	4.8	2.2	-1.8	1.4
Myopia	4.0	5.8	9.2	-0.8	2.8	-3.0
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.3	0.7	-1.1	2.3
Cholesterol lowering medication	1.3	2.0	5.5	-0.3	0.6	-2.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-1.2	-0.2	-0.7
Pain experienced in last month	1.6	2.6	5.7	-0.2	-1.5	2.4
Supplements: Calcium	1.1	1.2	2.1	-1.2	0.2	1.5
Basal cell carcinoma (self-reported)	0.7	0.9	1.3	-1.1	-0.5	1.0
Heart attack/myocardial infarction (self-reported)	1.9	2.4	4.4	-2.1	1.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	1.0	-0.0	0.3
Heart disease (siblings)	2.6	3.2	8.6	-0.8	2.9	-0.6
Alcohol drinker status: Previous	1.1	1.2	2.0	0.4	1.4	-1.2
Pack years of smoking	0.8	1.2	2.5	0.1	1.0	-1.6
Impedance of whole body	0.2	1.0	2.4	-0.5	-0.5	1.5
Leg fat mass (left)	0.5	1.9	3.2	1.5	0.6	-1.8
Arm predicted mass (left)	0.4	1.8	3.4	0.9	1.0	-1.9