Hub : Genes

KCTD5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.2900	0.0600	1.1e-09	0.190	NA	0.193	NA	0.195	1.8e-13	NA	1.1e-13	NA	8.4e-14
2	GTEx	Thyroid	0.2830	0.0520	3.1e-10	0.183	NA	0.195	NA	0.194	5.8e-14	NA	6.7e-15	NA	9.2e-15
3	YFS	Blood	0.0673	0.0251	2.4e-04	-0.001	0.009	0.011	0.011	0.000	6.7e-01	5.9e-04	8.6e-05	0.00014	5.2e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0228	0.0152	8.0e-03	0.021	0.011	0.003	NA	0.003	1.9e-03	2.0e-02	1.3e-01	NA	1.5e-01
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0620	0.0390	4.2e-03	0.008	0.023	0.041	NA	0.033	1.1e-01	1.7e-02	2.2e-03	NA	5.1e-03
6	TCGA	Thyroid Carcinoma	0.1220	0.0430	3.9e-15	0.203	0.139	0.186	NA	0.199	1.8e-19	1.9e-13	7.7e-18	NA	4.5e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.4	2.2	6.6	1.4	-0.7	1.9	-2.6	-0.6	-0.6
Bipolar Disorder or Schizophrenia	1.5	3.6	7.2	1.7	-1.7	2.5	-2.7	-0.6	-1.5
Depressed Affect (Nagel 2018)	1.2	2.4	6.5	-0.1	1.3	-1.2	2.5	-0.6	2.1
Depression (Nagel 2018)	0.6	0.9	1.6	-0.7	1.3	-0.7	1.2	-0.1	1.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.4	-0.9	-0.5	1.2	-1.0	-1.0	-0.3
Neuroticism (Nagel 2018)	1.2	2.7	6.9	0.0	1.8	-1.2	2.6	-0.3	2.1
Schizophrenia (2018)	0.9	2.0	4.2	1.0	-1.6	2.0	-1.4	-0.2	-1.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.3	-0.5	0.6	0.0	0.0	0.0
Worry (Nagel 2018)	0.4	0.8	1.2	1.0	0.9	-1.0	0.7	-1.1	0.5
Alzheimer’s Disease (in mother)	0.4	0.5	2.4	0.3	-0.2	-1.5	0.1	0.5	-0.2
Alzheimer’s Disease (in father)	1.1	1.2	4.2	0.3	-1.0	2.1	-0.9	-0.6	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.2	-0.5	0.3	-0.2	-0.2	-0.4
Crohns Disease (2017)	0.2	0.5	1.1	0.0	-0.5	0.9	-0.7	-1.1	-0.3
Irritable Bowel Disease (IBD)	0.4	1.0	4.2	1.1	-0.1	-0.0	-0.9	-2.0	-0.0
Ulcerative Colitis (UC)	0.6	1.2	4.5	1.4	0.2	-0.4	-0.7	-2.1	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	3.3	6.3	13.5	-3.7	2.4	1.0	1.9	3.2	2.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.8	-0.3	-0.6	-0.4	-0.3	-1.4	-0.5
Breast Cancer	0.2	0.4	1.6	-0.4	-0.5	0.2	-0.4	1.3	-0.5
Ovarian Cancer	0.4	0.5	1.5	-0.4	-0.5	1.2	0.8	0.7	0.4
Prostate Cancer	0.1	0.1	0.4	0.4	-0.7	0.1	0.2	-0.1	0.2
Age at First Birth	1.0	1.5	2.5	-1.5	0.9	-0.3	1.6	1.2	1.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.7	-0.2	1.2	0.6	1.3	0.5	1.3
Coronary Artery Disease (CAD)	0.9	1.0	2.8	0.0	0.0	0.0	1.7	1.3	1.4
Crohns Disease (2012)	0.2	0.4	1.2	-1.1	0.6	-0.0	0.1	0.3	0.8
Mean Putamen Volume	1.5	1.7	5.2	-0.5	1.2	1.4	2.3	0.3	1.1
Fasting Glucose	0.2	0.3	1.1	0.4	1.1	-0.3	0.3	-0.0	0.3
HbA1C	1.8	2.0	4.6	-0.8	2.2	0.8	1.0	0.9	2.0
HDL Cholesterol	0.8	1.3	2.8	-0.1	-1.2	1.7	-1.2	0.2	-1.3
LDL Cholesterol	0.4	0.7	2.2	0.2	0.6	-1.5	0.9	-0.4	0.7
Lupus	0.3	0.4	1.2	-0.8	1.1	0.2	0.0	0.0	0.7
Neuroticism (2016)	0.8	1.1	2.0	-1.1	1.4	-0.5	1.2	0.4	1.1
Primary Biliary Cirrhosis	0.4	0.6	2.0	0.1	-0.6	-0.5	-0.6	-1.4	-0.6
Rheumatoid Arthritis	0.5	0.6	2.6	-0.1	0.3	-1.6	0.6	0.9	0.1
Schizophrenia (2014)	0.7	1.6	6.0	0.6	-0.8	2.4	-1.5	0.4	-0.6
Triglycerides	0.4	0.6	2.6	0.1	0.3	-1.6	0.6	-0.1	0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.3	0.8	0.6	-0.5	0.7	-0.1	1.1
Ulcerative Colitis	0.5	0.8	1.9	0.8	0.8	-1.4	-0.1	-0.9	0.8
Blood Eosinophil Count	1.1	8.2	17.6	1.3	-2.8	0.2	-4.2	-3.3	-3.4
Blood Platelet Count	0.1	1.5	2.9	-1.1	0.5	-1.0	1.7	1.6	1.1
Blood Red Count	0.3	2.7	13.1	1.0	-0.1	-1.2	0.6	-3.6	0.5
Blood White Count	0.2	1.1	2.9	-0.9	0.5	0.1	1.5	1.7	0.8
Heel T-Score	0.1	1.0	2.2	-0.8	1.4	0.2	0.9	-0.6	1.5
BMI	0.8	4.6	10.7	-1.4	2.6	-2.2	1.6	0.8	3.3
Height	0.7	14.4	36.8	2.9	-4.9	1.3	-3.8	-1.0	-6.1
Waist Hip Ratio (WHR)	0.2	0.8	1.6	0.7	0.1	-1.1	1.3	-0.5	1.1
Systolic Blood Pressure	0.5	2.6	4.3	-0.0	-1.8	1.9	-2.1	-0.8	-2.0
Smoking Status	0.3	0.7	1.2	-1.1	1.1	-0.3	0.8	0.0	1.0
Allergy or Eczema	0.1	0.3	0.5	0.4	-0.5	0.7	0.7	-0.4	-0.4
Cardiovascular Disease	0.1	0.4	2.0	-0.0	0.2	1.4	-0.5	-0.4	0.3
Hypothyroidism (self reported)	5.3	12.2	25.4	-1.9	5.0	0.2	4.2	2.7	4.3
Respiratory disease	0.2	0.5	1.1	0.7	-0.5	0.0	-1.1	-0.8	-0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	5.9	-0.1	0.5	-2.4	0.2	-0.4	0.4
Lung FEV1/FVC ratio	0.3	1.4	3.5	-0.1	1.9	0.7	1.5	0.4	1.5
Lung FVC	0.1	0.7	1.9	-0.6	-0.3	1.4	-1.0	0.4	-0.7
Neuroticism	1.3	3.0	7.4	-0.9	1.6	-1.8	2.7	0.3	2.0
Chronotype (morning person)	0.5	1.2	2.6	-1.5	1.4	-0.2	0.0	1.6	0.7
Hair Pigment	0.0	1.1	3.1	-0.2	0.6	0.1	1.5	0.9	1.8
Tanning	0.1	1.3	2.8	1.3	-0.7	-0.1	-1.0	-1.3	-1.7
Hand grip strength (left)	3.2	8.4	15.1	2.2	-3.7	-0.1	-3.5	-2.0	-3.9
Number of treatments/medications taken	0.6	1.0	2.2	-0.3	1.5	0.4	1.5	-0.6	1.1
Average weekly spirits intake	0.5	0.6	2.7	0.4	0.0	0.6	0.1	-1.6	-0.3
Sensitivity / hurt feelings	2.2	3.8	8.6	-1.2	2.0	-0.8	2.4	1.4	2.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.1	0.6	0.4	0.4	-0.4	0.9
Hearing difficulty/problems: Yes	0.3	0.4	1.5	0.4	0.3	0.8	-0.3	-1.2	-0.0
Relative age of first facial hair	0.9	1.9	4.9	-0.8	2.2	-0.9	1.4	0.6	1.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.0	0.7	-1.0	1.1	-1.1	-1.4	-1.1
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.2	1.6	-0.9	-0.5	-1.4	-2.1	-0.4
Ever had hysterectomy (womb removed)	0.1	0.2	0.5	0.5	0.2	-0.3	-0.7	-0.3	0.1
Systolic blood pressure, automated reading	0.1	0.2	0.8	0.0	-0.1	0.9	-0.1	-0.7	-0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	-0.2	1.0	-1.0	0.1	-0.2	0.9
Angina	0.4	0.5	0.7	0.8	0.4	-0.8	0.7	-0.7	0.6
Medication for hormone replacement therapy	2.5	2.8	5.2	1.9	-2.3	0.1	-1.7	-1.5	-1.8
Vitamin and mineral supplements	0.7	1.0	2.4	0.3	-0.5	1.6	-1.0	-0.4	-1.3
Supplements: Zinc	0.2	0.3	0.9	0.0	0.6	-0.9	-0.1	0.3	0.4
Medication: Co-codamol	0.8	0.9	1.5	-0.7	0.6	-1.2	1.2	0.6	1.1
Medication: Metformin	1.0	1.5	8.0	-0.4	0.5	-2.8	-0.5	-0.1	0.3
Diabetes (father)	0.5	0.6	1.5	1.2	-0.6	-0.1	-0.7	-0.5	-0.8
Diabetes (mother)	1.4	1.8	5.8	1.9	-0.1	-2.4	-0.4	-1.1	-0.0
Severe depression (siblings)	0.3	0.3	0.5	-0.7	0.5	-0.4	0.2	0.7	0.7
Pack years adult smoking proportion	0.5	0.8	2.2	0.6	-0.2	-0.5	-1.2	-1.5	-0.8
Impedance of leg (right)	0.1	0.7	2.2	-0.3	-0.1	1.5	0.9	1.1	0.2
Leg fat-free mass (left)	0.2	0.9	1.2	0.5	-1.0	-1.1	-1.1	-1.0	-0.8
Trunk fat percentage	0.7	2.8	5.8	-2.1	1.4	-0.5	1.4	1.5	2.4
Hand grip strength (right)	3.9	10.5	19.3	2.6	-4.4	-0.4	-3.7	-2.2	-4.2
Townsend deprivation index at recruitment	0.3	0.4	0.9	-0.7	0.9	-0.1	0.3	-0.0	0.9
Current tobacco smoking	0.9	1.4	3.1	-0.9	1.2	-1.8	1.4	0.4	1.1
Average weekly fortified wine intake	0.4	0.5	1.2	-0.5	0.2	1.1	-0.7	-0.3	-1.0
Maternal smoking around birth	0.3	0.4	0.8	-0.9	0.9	-0.2	0.5	-0.7	0.4
Fed-up feelings	0.6	1.1	1.8	-0.2	0.3	-1.4	1.2	-1.3	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.1	-1.0	0.8	-0.7	0.5	0.7	0.8
Relative age voice broke	1.9	2.9	8.4	-1.2	2.9	-0.8	1.7	0.9	1.9
Taking other prescription medications	0.2	0.4	0.8	0.5	0.9	-0.1	-0.7	-0.8	-0.4
Age when periods started (menarche)	0.3	0.6	2.3	0.0	0.4	-1.5	-0.9	0.7	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.2	0.4	0.2	-1.1	0.1	0.0	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.1	0.5	0.5	-0.2	-0.9	0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	0.0	-0.2	-1.5	0.2	-0.0	0.1
Qualifications: CSEs or equivalent	0.6	0.7	2.5	-0.4	1.0	-0.3	0.7	1.6	0.4
Serious illness, injury or assault to yourself	0.8	0.9	1.4	1.1	-1.2	-0.8	-0.8	-1.0	-0.8
High blood pressure	0.2	0.4	0.8	0.7	-0.3	0.8	-0.7	-0.9	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.5	-0.4	0.3	1.2	1.0	0.2	0.0
Multivitamins +/- minerals	0.7	0.9	3.2	-0.6	0.1	-1.8	1.1	0.1	0.9
Stomach or abdominal pain in last month	1.0	1.3	4.8	2.2	-1.0	0.4	-0.0	-1.3	0.1
Supplements: Glucosamine	0.7	0.9	2.6	-0.7	0.8	0.7	1.0	-0.0	1.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.2	-0.7	-0.4	0.0	0.3	-0.3
Medication: Atenolol	0.4	0.5	1.9	0.2	0.4	1.4	0.4	0.4	0.8
Medication: Levothyroxine sodium	2.2	3.7	6.7	0.2	2.6	1.3	2.5	1.3	2.4
Sitting height	2.2	15.4	26.0	3.8	-4.8	0.3	-4.0	-3.6	-5.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	-0.3	0.2	1.0	-0.9	-0.3	0.6
High blood pressure (mother)	0.3	0.4	0.7	-0.8	0.2	0.8	0.6	0.1	0.8
Body mass index (BMI)	0.5	2.2	5.4	-0.9	2.0	-1.2	1.0	-0.1	2.3
Impedance of leg (left)	0.2	0.8	1.8	-0.5	-0.3	1.3	0.9	1.3	0.1
Leg predicted mass (left)	0.2	0.8	1.1	0.5	-1.0	-1.0	-1.0	-1.0	-0.8
Trunk fat mass	0.3	1.1	2.4	-1.3	0.7	-0.7	0.9	0.9	1.6
Waist circumference	0.5	2.0	4.0	-1.4	1.6	-1.4	1.2	0.6	2.0
Number of incorrect matches in round	0.2	0.4	1.4	1.2	-0.6	-0.3	-0.1	0.2	0.4
Past tobacco smoking	0.1	0.1	0.4	0.7	0.2	-0.3	0.4	-0.2	0.2
Alcohol usually taken with meals	0.2	0.3	1.2	0.3	-0.7	0.2	-0.1	-0.0	-1.1
Nervous feelings	0.3	0.6	1.2	1.1	-0.2	-0.2	-0.4	-1.1	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.5	1.1	-0.8	-0.8	-0.7	-1.9	-1.4
Hearing difficulty/problems with background noise	0.4	0.6	1.8	-0.6	0.9	1.4	-0.7	-0.6	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	2.5	0.7	-0.8	-0.0	-1.6	-0.8	-1.1
Had menopause	0.1	0.1	0.5	0.1	0.7	-0.1	-0.3	-0.0	-0.0
Had other major operations	1.4	1.8	4.8	-0.3	1.6	0.5	2.2	-0.3	1.6
Forced vital capacity (FVC)	0.8	3.0	7.3	1.1	-2.3	0.4	-1.9	-0.4	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.0	0.6	-0.1	0.5	-0.9	-1.4	-0.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.3	1.8	-0.9	0.8	-1.2	-1.3	-0.7
Qualifications: None of the above	1.2	2.6	4.4	-1.6	2.1	-1.0	0.8	2.1	1.5
Financial difficulties in last 2 years	6.3	8.5	12.9	-2.7	3.4	-1.6	3.5	2.1	3.6
Mouth/teeth dental problems	2.8	4.4	7.7	2.2	-2.4	0.8	-2.8	-1.8	-2.1
Heart attack	0.7	0.9	2.7	1.1	-0.6	-0.6	-0.3	-1.6	-0.9
Allergy	0.2	0.4	1.7	0.5	-0.5	-0.4	-1.3	-0.1	-0.2
Pain all over the body in last month	0.6	0.6	2.1	0.7	0.8	-0.5	0.2	-1.5	0.5
Diabetes (self-reported)	0.6	1.0	4.3	-0.3	0.7	-2.1	-0.4	-0.7	0.7
Hayfever/allergic rhinitis (self-reported)	1.9	2.6	4.5	-1.5	1.9	-0.2	2.1	2.0	1.1
Medication: Ramipril	0.9	1.1	2.5	-0.7	1.5	-0.7	1.6	0.1	0.9
Medication: Simvastatin	0.1	0.1	0.8	0.2	-0.1	0.1	0.1	-0.9	-0.0
Fluid intelligence score	0.7	1.5	5.6	1.2	-1.2	0.0	-0.3	-2.4	-0.7
Illnesses of siblings	0.6	0.8	1.9	-1.0	0.6	-1.3	1.4	0.2	0.2
Neuroticism score	0.3	0.7	1.5	0.3	0.1	-1.2	1.2	-0.8	0.4
Weight	0.0	0.2	1.0	-0.3	-0.1	-1.0	-0.0	-0.3	0.4
Impedance of arm (right)	0.8	3.7	10.4	-2.6	0.0	1.3	1.6	3.2	0.8
Arm fat percentage (right)	1.0	3.9	8.4	-1.9	1.9	-1.1	2.0	1.5	2.9
Trunk fat-free mass	0.7	4.3	5.9	2.4	-2.1	-1.1	-1.8	-2.3	-2.4
Hip circumference	0.1	0.2	0.6	-0.4	0.1	-0.7	-0.7	-0.0	0.0
Time employed in main current job	2.8	3.3	6.3	2.5	-1.3	0.2	-2.1	-2.1	-1.7
Alcohol intake versus 10 years previously	0.2	0.3	1.2	0.2	-0.7	-1.1	-0.1	0.0	-0.3
Father’s age at death	1.7	2.3	5.0	1.4	-1.6	-0.3	-2.2	-1.1	-1.8
Worrier / anxious feelings	0.1	0.2	0.3	0.4	-0.0	0.5	0.5	-0.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.1	0.1	0.1	-0.3	-0.5	0.5
Falls in the last year	2.4	3.3	7.3	-0.2	2.7	-0.5	2.4	-0.2	2.5
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	-1.0	-0.4	1.1	-0.0	1.3	-0.6
Number of live births	0.3	0.4	1.1	-0.5	0.4	-1.1	-0.7	-0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.5	0.9	-1.3	0.2	-1.1	-0.0	-1.9
Pulse rate	2.5	4.2	13.4	2.1	-1.4	-0.4	-1.2	-3.7	-1.9
Happiness	0.2	0.2	0.6	0.1	-0.6	0.8	-0.3	0.2	0.1
Noisy workplace	1.5	1.8	2.8	-1.6	1.7	-0.3	0.8	1.5	1.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	-0.0	-0.9	0.7	-0.5	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	-0.2	0.4	1.1	1.0	-1.2	0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	2.7	-1.6	1.3	-0.5	1.6	0.8	1.1
Asthma	0.1	0.1	0.4	0.1	-0.2	-0.6	-0.1	-0.4	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-1.2	0.3	-0.6	1.3	0.1	1.3
Medication: Cholesterol lowering	0.2	0.2	0.8	0.3	0.1	-0.9	0.2	-0.7	0.3
Depression (self-reported)	0.6	0.7	1.5	-0.7	1.1	-0.1	0.6	1.2	0.8
Medication: Lansoprazole	0.9	1.1	3.1	-0.4	0.9	-0.4	1.8	-0.0	1.5
Prospective memory result	0.6	0.8	3.2	-1.0	0.6	0.3	-0.3	1.8	0.1
Lung cancer (father)	0.4	0.5	1.4	-0.3	-0.3	-1.1	-0.2	1.2	-0.4
Illnesses of mother	0.6	0.7	2.2	-1.5	0.5	0.5	0.2	1.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	0.9	-0.7	0.5	-0.2	0.2	-1.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	0.1	1.3	-0.6	0.5	-0.2	1.2
Impedance of arm (left)	0.7	3.1	8.5	-2.5	-0.2	1.6	1.2	2.9	0.7
Arm fat mass (right)	0.5	1.9	4.7	-1.2	1.4	-0.9	1.2	0.8	2.2
Trunk predicted mass	0.7	4.1	5.6	2.4	-2.1	-1.0	-1.7	-2.2	-2.3
Standing height	0.8	8.3	21.2	1.9	-4.6	0.5	-2.3	-1.0	-4.3
Length of working week for main job	0.5	0.5	1.4	-0.9	0.3	0.6	1.2	0.2	0.6
Exposure to tobacco smoke at home	0.7	0.8	2.3	0.1	0.4	-1.5	1.0	-0.4	1.1
Breastfed as a baby	0.5	0.7	2.1	0.8	-0.2	1.5	-0.8	-0.5	-0.4
Tense / ‘highly strung’	0.8	1.3	4.0	1.5	-0.2	-0.2	-1.0	-2.0	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	1.5	-0.1	-0.3	-0.7	-1.5	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-0.1	-0.1	0.8	0.9	0.1	1.1
Birth weight of first child	0.1	0.3	1.0	0.4	0.3	-0.4	1.0	0.3	0.1
Peak expiratory flow (PEF)	0.7	1.7	3.2	0.9	-1.1	-0.8	-1.8	-1.1	-1.8
Pulse wave reflection index	0.3	0.3	0.8	0.5	0.7	0.9	-0.2	0.3	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.4	0.2	0.4	-1.6	-0.2	-0.8	0.5
Loud music exposure frequency	0.2	0.2	0.6	-0.0	-0.2	-0.6	-0.6	-0.8	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.1	0.9	-0.2	0.2	0.1	-1.1	0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	-0.2	0.4	0.1	1.3	1.4	0.6
Blood clot in the leg (DVT)	0.8	1.0	3.2	-1.8	1.1	0.1	0.8	0.5	0.8
Medication: Paracetamol	1.5	2.5	6.2	-1.8	1.0	-0.2	2.5	0.7	2.0
Headache pain in last month	0.8	1.4	4.3	1.8	-0.9	0.0	-0.0	-2.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	0.5	-0.5	-0.6	-0.6	0.0	-0.6
Glaucoma (self-reported)	1.2	1.4	2.1	-1.4	1.3	1.4	1.3	0.4	0.7
Gout (self-reported)	0.5	0.7	2.4	0.6	-0.7	-0.3	-0.2	-1.5	-1.0
Hypothyroidism/myxoedema (self-reported)	5.4	10.5	20.6	-1.4	4.5	0.6	4.1	2.6	4.1
Medication: Amlodipine	0.4	0.5	0.8	0.9	-0.8	-0.7	-0.6	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	-0.2	0.3	0.1	0.7	0.0	-0.6
Birth weight	0.2	0.3	1.2	0.3	-1.1	0.1	-0.5	0.2	-0.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.2	0.3	1.2	1.8	-0.5	-1.0	0.0
High blood pressure (siblings)	0.5	0.7	2.1	0.8	-0.7	0.7	-1.5	-0.3	-0.4
Forced vital capacity (FVC), Best measure	0.7	2.5	5.0	1.7	-2.0	0.7	-1.5	-0.6	-2.2
Body fat percentage	0.8	3.1	7.1	-1.9	1.6	-0.8	1.7	1.4	2.7
Leg fat percentage (right)	0.8	2.8	7.4	-1.2	1.9	-0.9	1.7	0.8	2.7
Arm fat-free mass (right)	0.6	3.1	4.8	2.0	-1.7	-0.6	-1.9	-2.2	-1.8
Exposure to tobacco smoke outside home	3.4	4.5	8.9	-0.6	2.3	-2.1	3.0	1.3	2.5
Comparative body size at age 10	0.2	0.6	1.7	-0.6	0.6	-0.8	0.4	-0.3	1.3
Number of full brothers	0.8	1.0	2.2	-0.4	1.1	0.2	0.5	1.4	1.5
Worry too long after embarrassment	0.3	0.6	1.1	0.9	-0.7	-0.1	-1.0	-0.8	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.5	1.8	-0.9	-0.4	-0.8	-1.9	-0.6
Wheeze or whistling in the chest in last year	0.6	1.1	4.0	-0.4	0.9	-0.6	2.0	-0.5	1.1
Number of children fathered	1.0	1.2	2.5	-0.0	1.6	1.2	1.0	-0.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.8	1.2	-1.2	0.1	-1.4	-0.4	-1.7
Age at first live birth	0.9	1.6	3.0	-1.3	1.1	0.4	1.4	1.7	1.3
Pulse wave peak to peak time	0.5	0.6	1.7	-0.2	-1.3	0.6	-0.3	0.4	-1.1
Health satisfaction	0.6	0.8	2.2	0.7	0.1	1.5	-0.6	-1.3	-0.1
Shortness of breath walking on level ground	0.5	0.6	1.9	0.4	0.5	-1.4	-0.3	-1.0	-0.0
Qualifications: College or University degree	0.3	0.9	2.0	0.8	-1.4	-0.1	-0.9	-1.2	-0.7
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.5	-0.7	-0.2	0.0	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.6	-1.4	0.7	-0.3	1.7	1.9	1.7
Emphysema/chronic bronchitis	1.3	1.5	3.4	-0.9	1.8	-0.2	1.0	0.5	1.8
Medication for pain relief, constipation, heartburn	0.7	1.3	3.2	0.5	-0.6	0.8	-1.8	1.3	-1.2
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.3	-0.3	0.4
Medication: Blood pressure	0.3	0.5	1.2	0.5	-0.2	1.1	-0.7	-0.9	-0.5
Angina (self-reported)	0.4	0.5	0.8	0.9	0.5	-0.8	0.6	-0.9	0.5
Migraine (self-reported)	0.3	0.4	0.8	-0.1	0.9	-0.2	-0.3	0.9	0.7
Medication: Ibuprofen	0.6	0.7	1.5	-1.1	0.3	-0.5	1.2	0.2	1.0
Medication: Allopurinol	0.8	1.0	2.7	0.4	-0.0	-1.6	1.0	-1.5	-0.1
Medication: Omeprazole	3.3	3.9	9.2	2.1	-1.7	-0.0	-3.0	-1.8	-1.9
Medication: Seretide 50 evohaler	1.5	1.7	3.5	-1.0	1.4	-0.5	1.9	0.6	1.9
Mean time to correctly identify matches	4.4	8.5	17.9	-4.2	2.5	0.5	2.4	4.0	2.2
Heart disease (mother)	0.5	0.6	1.9	-0.6	0.5	0.5	1.4	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	-1.1	-0.0	-0.7	1.2	1.0	0.2
Whole body fat mass	0.3	1.4	3.2	-1.2	0.9	-0.8	1.2	0.7	1.8
Leg fat mass (right)	0.4	1.4	4.0	-0.9	1.2	-0.9	1.2	0.3	2.0
Arm predicted mass (right)	0.7	3.5	5.3	2.2	-1.8	-0.6	-1.9	-2.3	-1.8
Pulse rate, automated reading	0.2	0.8	3.1	0.0	0.3	-0.3	-0.4	-1.8	-1.2
Alcohol intake frequency.	0.3	0.7	2.8	1.7	-0.2	0.2	0.3	-1.2	0.4
Comparative height size at age 10	0.7	3.7	8.8	1.6	-3.0	-0.3	-1.7	-1.3	-2.4
Number of full sisters	2.3	2.8	4.4	-1.8	1.6	-2.1	0.5	1.8	1.7
Suffer from ‘nerves’	0.5	0.8	1.6	1.0	0.9	-1.3	0.0	-1.1	-0.3
Overall health rating	0.4	0.8	2.6	-0.2	1.6	-0.3	0.6	-0.7	1.1
Chest pain or discomfort	0.2	0.4	1.6	0.1	-0.1	-1.3	0.7	-0.0	0.1
Had major operations	0.8	0.9	4.5	0.3	0.1	-0.1	-0.7	-2.1	-0.7
Age at last live birth	1.3	1.9	4.9	-1.5	1.3	-0.1	1.3	2.2	1.2
Family relationship satisfaction	0.6	0.7	1.9	0.8	0.8	1.4	0.1	-0.6	0.9
Leg pain on walking	0.4	0.5	1.9	-0.7	0.1	0.4	-1.4	-0.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.7	0.6	-0.3	-0.9	1.3	0.1	1.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	0.5	-0.2	0.2	-0.6	-1.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	-0.6	-0.8	0.7	-0.1	1.4	-0.8
Medication: Aspirin	0.6	0.8	2.8	1.3	-0.2	0.0	-0.7	-1.7	-0.2
Supplements: Vitamin C	0.4	0.5	1.0	-0.7	0.6	-0.7	0.2	0.6	1.0
Knee pain experienced in last month	0.8	1.2	6.2	-0.3	-0.1	-2.5	-0.9	-0.1	0.1
Hypertension (Self-reported)	0.1	0.4	0.7	0.6	-0.2	0.8	-0.8	-0.8	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	0.1	1.1	-0.6	0.9	-1.0	0.6
Illnesses of father: Heart disease	0.5	0.7	1.3	-1.0	0.4	-0.2	1.0	1.1	0.7
Illnesses of siblings: Diabetes	0.7	0.9	2.4	1.1	0.8	-0.8	0.6	-0.1	1.6
Smoking status: Previous	0.2	0.2	0.9	-0.3	-0.3	1.0	-0.3	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.8	0.6	-0.9	-0.7	-0.1	-1.1	-1.3
Whole body fat-free mass	0.5	2.8	3.6	1.8	-1.8	-1.0	-1.6	-1.9	-1.8
Leg fat-free mass (right)	0.2	1.1	1.6	0.6	-1.3	-1.0	-1.2	-1.0	-1.1
Arm fat percentage (left)	0.8	3.3	7.6	-1.9	1.8	-0.9	1.7	1.4	2.8
Average weekly red wine intake	0.3	0.5	1.1	-0.9	-0.2	-1.0	0.7	0.7	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.8	0.4	-0.4	0.4	0.6	-0.3
Mood swings	0.7	1.3	3.4	-0.2	0.8	-1.4	1.8	0.1	1.4
Loneliness, isolation	0.5	0.6	1.4	1.0	-0.4	-0.2	-1.2	-1.0	-0.5
Long-standing illness, disability or infirmity	1.1	1.7	4.5	-0.7	2.1	-0.8	1.2	0.1	1.7
Ever had bowel cancer screening	0.4	0.4	1.0	0.9	0.1	0.7	0.5	-0.4	1.0
Diabetes diagnosed by doctor	0.9	1.5	6.0	-0.7	1.2	-2.5	0.5	0.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.0	-1.4	0.4	1.1	-0.3	0.7	0.1
Friendships satisfaction	1.7	2.1	3.9	1.2	-1.9	0.8	-2.0	-0.6	-1.6
Qualifications: nursing, teaching	0.4	0.6	1.5	-0.5	-1.2	0.5	-0.3	0.9	-0.9
Commuting to job workplace: Walk	2.3	2.5	4.3	-1.6	1.7	0.3	2.1	1.4	1.8
Eye problems/disorders: Cataract	0.5	0.6	1.2	0.5	-0.1	-1.1	-1.1	-0.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	-1.0	1.4	0.6	0.7	0.2	0.9
Medication for cholesterol	0.3	0.5	1.6	0.3	0.6	0.2	0.9	-0.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.6	-0.5	0.3	0.1	-0.4	-0.3
Back pain experienced in last month	0.7	1.1	4.1	-0.1	-1.0	-0.3	0.1	-2.0	-1.1
Mineral and other dietary supplements	1.3	1.7	3.2	-1.8	1.6	-0.5	1.3	1.3	1.1
Breast cancer (self-reported)	0.3	0.4	1.0	0.3	0.6	0.2	1.0	0.1	1.0
Asthma (self-reported)	0.1	0.2	0.5	0.1	-0.4	-0.7	-0.1	-0.5	-0.7
Osteoporosis (self-reported)	0.4	0.5	1.9	0.4	-0.6	-1.4	-0.4	0.2	-0.7
Osteoarthritis (self-reported)	0.8	1.1	1.6	-1.1	1.3	-1.1	1.1	0.0	1.1
Medication: Aspirin	0.8	1.0	3.5	1.2	-0.3	-0.0	-0.9	-1.9	-0.4
Medication: Gliclazide	0.9	1.0	3.5	-0.9	-0.4	-1.9	-0.4	1.2	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.5	-0.0	0.5	-0.1	-0.0	-0.1
Smoking status: Current	0.6	1.0	3.0	-0.5	0.8	-1.7	1.2	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	1.2	-0.8	1.1	-0.4	-0.5	-0.5
Whole body water mass	0.5	2.7	3.3	1.7	-1.8	-1.1	-1.6	-1.8	-1.8
Leg predicted mass (right)	0.2	1.1	1.6	0.6	-1.2	-1.0	-1.2	-1.1	-1.1
Arm fat mass (left)	0.4	1.6	4.0	-1.2	1.2	-1.2	1.0	0.6	2.0
Number of self-reported non-cancer illnesses	0.7	1.2	3.4	-0.4	1.8	-0.2	1.3	-0.6	1.3
Average weekly champagne plus white wine intake	0.5	0.6	1.5	1.2	-1.0	-0.3	-0.7	-0.1	-0.8
Miserableness	0.2	0.3	1.0	0.2	-0.2	-0.6	1.0	-0.1	0.5
Guilty feelings	1.8	2.7	5.7	-1.3	1.6	-1.5	2.4	0.2	1.9
Wears glasses or contact lenses	0.1	0.1	0.3	-0.3	-0.2	-0.6	0.3	0.1	0.3
Ever taken oral contraceptive pill	0.4	0.4	1.3	0.3	-1.2	-0.7	0.3	-0.5	-0.6
Hearing aid user	2.1	2.4	4.6	-1.2	2.1	-0.9	1.6	1.1	1.9
Mother’s age at death	0.6	0.8	2.4	1.6	-0.3	-1.1	-0.4	-0.8	-0.2
Financial situation satisfaction	3.2	3.9	5.9	-2.0	2.4	1.1	2.2	1.5	2.4
Tinnitus: Yes, now most or all of the time	2.0	2.4	4.3	0.9	-2.0	1.1	-1.2	-2.1	-1.6
Commuting to job workplace: Public transport	0.9	1.0	2.0	-1.0	0.5	1.4	1.1	1.1	0.6
Eye problems/disorders: Glaucoma	1.0	1.2	4.0	-2.0	1.2	-0.1	1.1	0.6	0.3
Medication: Blood pressure	0.6	1.1	2.2	-1.5	1.2	-0.6	0.7	1.3	0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.5	-1.6	-0.4	1.0	-0.3	0.5	0.1
Supplements: Fish oil (including cod liver oil)	3.4	4.4	7.2	2.7	-2.3	0.9	-2.1	-2.2	-1.9
High cholesterol (Self-reported)	0.2	0.4	1.2	0.4	0.1	1.1	-0.1	-0.8	0.3
Medication: Bendroflumethiazide	0.2	0.4	0.7	-0.8	0.6	-0.2	0.7	0.6	0.3
Medication: Paracetamol	2.3	3.6	7.1	-2.3	1.4	-0.3	2.7	1.5	2.2
Medication: Lisinopril	0.4	0.6	2.2	-1.5	0.5	0.4	0.7	0.3	0.3
Medication: Atorvastatin	0.9	1.2	3.1	-0.7	1.5	-0.5	0.8	0.6	1.8
Illnesses of father: High blood pressure	0.8	1.0	3.2	-1.8	-0.4	-0.5	0.4	1.5	0.1
Alcohol drinker status: Never	1.3	1.5	3.6	1.9	-1.0	1.6	-0.2	-1.4	0.1
Ever smoked	0.2	0.3	0.7	-0.8	-0.2	0.4	-0.6	0.7	-0.2
Basal metabolic rate	0.3	1.6	2.2	1.2	-1.3	-1.1	-1.2	-1.5	-1.2
Leg fat percentage (left)	0.9	3.2	7.6	-1.4	1.9	-1.3	1.8	1.1	2.8
Arm fat-free mass (left)	0.4	2.3	4.1	1.7	-1.3	-1.1	-1.4	-2.0	-1.3
Number of operations (self-reported)	0.8	1.2	2.5	-0.4	1.6	-0.2	1.1	-1.6	0.9
Average weekly beer plus cider intake	0.5	0.7	1.2	-1.1	1.1	0.1	0.7	0.5	1.0
Irritability	0.4	0.6	2.7	-0.2	-0.1	-1.0	1.6	-0.2	0.1
Risk taking	0.3	0.4	1.4	-1.2	-0.2	0.6	-0.4	0.6	-0.0
Ever had prostate specific antigen (PSA) test	2.8	3.2	6.6	1.9	-2.6	0.5	-0.8	-1.8	-2.2
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.3	0.4	-0.2	-0.6	0.2	0.6
Age started oral contraceptive pill	1.6	1.9	3.2	-1.7	1.8	1.2	0.7	1.3	1.4
Diastolic blood pressure, automated reading	0.3	0.9	2.3	0.6	0.3	1.5	0.5	-1.4	0.4
Ever depressed for a whole week	0.4	0.5	2.5	-0.5	0.5	1.6	-0.0	0.0	0.2
Unable to work because of sickness or disability	0.7	0.9	3.1	-0.3	1.3	-1.8	0.1	-0.3	0.5
Commuting to job workplace: Cycle	0.9	1.1	2.4	-1.3	0.3	-1.0	0.6	1.5	1.0
Myopia	0.1	0.2	0.8	0.9	-0.3	0.5	-0.3	-0.2	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.0	-0.7	0.0	-0.7	0.3	1.0	0.1
Cholesterol lowering medication	0.3	0.4	1.2	0.3	-0.2	-0.1	-0.9	-1.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	5.7	1.7	-1.4	-0.5	-2.4	-1.5	-1.7
Pain experienced in last month	0.5	0.9	3.1	-0.7	0.1	1.3	0.1	1.8	0.5
Supplements: Calcium	2.9	3.2	5.2	1.5	-1.0	-1.7	-2.3	-2.1	-1.8
Basal cell carcinoma (self-reported)	0.7	0.8	2.5	0.4	0.1	1.6	-0.4	-1.4	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.3	0.8	-0.2	-0.7	0.0	-1.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.7	-1.7	0.8	0.3	0.8	0.5	0.6
Heart disease (siblings)	0.5	0.6	1.1	0.3	0.5	1.1	0.7	0.8	0.9
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.7	0.4	-1.0	0.9	0.4	0.2
Pack years of smoking	0.2	0.4	1.2	0.3	0.2	-0.5	-0.7	-1.1	-0.3
Impedance of whole body	0.4	2.3	5.5	-1.7	-0.3	1.9	1.1	2.3	0.5
Leg fat mass (left)	0.4	1.6	3.9	-1.1	1.1	-1.1	1.2	0.5	2.0
Arm predicted mass (left)	0.4	2.2	3.3	1.8	-1.4	-1.0	-1.4	-1.8	-1.4