Hub : Genes

KHDRBS2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0760 0.0280 8.3e-06 0.038 0.045 0.029 0.047 0.041 1.8e-05 3.0e-06 0.00015 1.8e-06 8.7e-06
2 TCGA Lung Squamous Cell Carcinoma 0.0584 0.0308 6.7e-03 0.011 0.023 0.007 NA 0.010 1.9e-02 1.2e-03 0.04300 NA 2.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.4 0.8 0.3 -0.9
Bipolar Disorder or Schizophrenia 1.0 2.5 3.9 -1.0 2.0
Depressed Affect (Nagel 2018) 0.6 1.2 2.2 1.5 -0.5
Depression (Nagel 2018) 0.3 0.5 0.8 0.5 0.9
Intelligence (Savage-Jansen 2018) 0.6 1.7 3.5 1.9 0.2
Neuroticism (Nagel 2018) 0.3 0.8 0.8 0.9 -0.9
Schizophrenia (2018) 3.1 6.5 10.8 -1.5 3.3
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.4 0.2
Worry (Nagel 2018) 0.0 0.0 0.1 0.2 -0.2
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 -0.0 0.2
Alzheimer’s Disease (in father) 1.0 1.1 2.0 -0.5 1.4
Alzheimer’s Disease (including proxy) 0.3 0.5 0.8 0.3 0.9
Crohns Disease (2017) 0.0 0.1 0.1 -0.2 -0.3
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.2 -0.1
Ulcerative Colitis (UC) 0.1 0.1 0.1 -0.3 0.4
Major Depression (MDD) 0.3 0.4 0.4 -0.6 0.6
Reaction Time 0.1 0.2 0.4 -0.2 0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.3 1.5 0.4
Breast Cancer 0.3 0.8 1.5 -0.4 1.2
Ovarian Cancer 0.2 0.2 0.3 -0.6 -0.4
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.6 0.8 1.5 -0.3 -1.2
Bipolar Disorder (2011) 0.7 0.7 1.0 -1.0 0.6
Body Mass Index (BMI) (2010) 0.4 0.6 0.8 0.9 0.6
Coronary Artery Disease (CAD) 0.4 0.5 0.9 1.0 0.2
Crohns Disease (2012) 1.1 1.7 3.4 -1.9 -0.1
Mean Putamen Volume 0.3 0.3 0.5 -0.3 -0.7
Fasting Glucose 1.1 1.3 2.1 0.7 1.4
HbA1C 0.5 0.6 1.2 -0.0 1.1
HDL Cholesterol 0.6 1.1 2.1 -0.0 -1.5
LDL Cholesterol 0.2 0.3 0.4 -0.6 0.5
Lupus 0.2 0.4 0.6 -0.3 -0.8
Neuroticism (2016) 0.6 0.9 1.3 -0.7 1.1
Primary Biliary Cirrhosis 0.9 1.3 2.3 -0.5 1.5
Rheumatoid Arthritis 1.2 1.6 2.5 0.8 -1.6
Schizophrenia (2014) 1.4 3.2 6.2 -0.3 2.5
Triglycerides 1.1 1.8 3.2 -0.6 1.8
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.3 0.3 -1.5
Ulcerative Colitis 0.0 0.0 0.1 -0.3 -0.0
Blood Eosinophil Count 0.1 0.8 1.3 -0.5 1.2
Blood Platelet Count 0.1 1.4 2.8 0.2 1.7
Blood Red Count 1.6 15.7 27.9 -1.9 5.3
Blood White Count 0.1 0.9 1.3 -0.7 1.1
Heel T-Score 0.6 4.6 8.4 -0.9 2.9
BMI 1.6 9.3 15.3 -1.8 3.9
Height 0.5 9.9 19.4 -0.6 -4.4
Waist Hip Ratio (WHR) 0.5 2.1 4.0 0.4 2.0
Systolic Blood Pressure 0.2 0.8 1.6 -0.3 1.2
Smoking Status 0.8 2.0 2.6 -1.6 1.2
Allergy or Eczema 1.7 4.5 6.6 -1.6 2.6
Cardiovascular Disease 1.9 6.1 8.9 -1.8 3.0
Hypothyroidism (self reported) 0.2 0.4 0.5 -0.6 0.7
Respiratory disease 0.5 1.2 2.4 0.1 1.6
Type 2 Diabetes (T2D) (2018) 1.7 3.1 5.7 0.7 2.4
Lung FEV1/FVC ratio 1.0 5.3 10.2 0.6 3.2
Lung FVC 0.6 3.2 6.4 -0.3 2.5
Neuroticism 0.6 1.5 2.1 1.5 -0.9
Chronotype (morning person) 1.1 2.5 3.0 -1.7 1.4
Hair Pigment 0.0 0.5 0.9 0.3 -1.0
Tanning 0.0 0.3 0.4 -0.6 -0.3
Hand grip strength (left) 0.2 0.4 0.7 -0.8 0.4
Number of treatments/medications taken 2.4 4.3 8.5 -0.4 2.9
Average weekly spirits intake 0.1 0.1 0.3 -0.2 0.5
Sensitivity / hurt feelings 0.6 1.0 1.9 -0.4 1.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.1 1.0 -0.1
Hearing difficulty/problems: Yes 0.7 1.0 2.0 -0.2 -1.4
Relative age of first facial hair 0.9 1.8 2.7 -0.9 -1.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.4 0.5 0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.2 -0.5 0.5
Ever had hysterectomy (womb removed) 0.1 0.2 0.2 0.5 -0.3
Systolic blood pressure, automated reading 0.7 2.0 3.1 -0.9 1.8
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 3.7 -0.5 1.9
Angina 0.4 0.6 1.1 0.2 1.0
Medication for hormone replacement therapy 1.9 2.2 3.5 -1.9 0.9
Vitamin and mineral supplements 0.1 0.1 0.3 -0.0 -0.5
Supplements: Zinc 0.9 1.0 1.9 -0.3 1.4
Medication: Co-codamol 1.5 1.7 2.2 -1.5 1.1
Medication: Metformin 0.5 0.7 0.8 0.8 0.9
Diabetes (father) 1.9 2.3 3.8 -1.0 1.9
Diabetes (mother) 0.2 0.2 0.4 -0.2 0.6
Severe depression (siblings) 0.4 0.5 0.9 0.1 1.0
Pack years adult smoking proportion 0.3 0.5 0.9 -1.0 -0.3
Impedance of leg (right) 1.3 6.4 11.0 1.3 -3.3
Leg fat-free mass (left) 0.3 1.5 1.8 -1.3 1.1
Trunk fat percentage 0.2 0.8 1.5 -0.1 1.2
Hand grip strength (right) 0.3 0.9 1.3 -1.1 -0.7
Townsend deprivation index at recruitment 0.0 0.1 0.1 -0.2 -0.3
Current tobacco smoking 1.4 2.3 4.4 -2.1 -0.4
Average weekly fortified wine intake 0.4 0.4 0.7 0.8 -0.4
Maternal smoking around birth 0.1 0.2 0.3 0.5 -0.2
Fed-up feelings 0.0 0.0 0.1 0.2 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 0.0 0.5
Relative age voice broke 1.7 2.7 5.3 -0.2 -2.3
Taking other prescription medications 0.9 1.3 2.5 -0.4 1.6
Age when periods started (menarche) 1.9 4.5 6.2 1.6 -2.5
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 3.1 1.8 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 0.9 0.8 0.9
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 3.8 -2.0 0.6
Qualifications: CSEs or equivalent 0.5 0.7 1.1 1.0 -0.5
Serious illness, injury or assault to yourself 0.1 0.1 0.1 -0.3 0.3
High blood pressure 3.1 8.5 14.8 -1.5 3.9
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.0 -0.4 1.7
Multivitamins +/- minerals 0.4 0.5 0.9 0.9 -0.3
Stomach or abdominal pain in last month 0.5 0.6 0.8 0.6 -0.9
Supplements: Glucosamine 0.3 0.4 0.7 0.2 0.8
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 1.2 1.1 -1.0
Medication: Atenolol 0.5 0.6 1.2 0.1 1.1
Medication: Levothyroxine sodium 0.8 1.3 1.7 -1.3 0.9
Sitting height 0.4 2.5 4.0 -2.0 -1.0
Chronic bronchitis/emphysema (father) 0.4 0.5 1.0 -0.0 -1.0
High blood pressure (mother) 1.3 1.9 3.2 -0.7 1.8
Body mass index (BMI) 1.1 4.7 9.2 -0.4 3.0
Impedance of leg (left) 1.1 5.3 9.4 1.1 -3.1
Leg predicted mass (left) 0.3 1.4 1.6 -1.3 1.1
Trunk fat mass 0.2 0.9 1.7 -0.4 1.3
Waist circumference 1.4 5.2 10.2 -0.4 3.2
Number of incorrect matches in round 0.0 0.1 0.1 -0.2 -0.3
Past tobacco smoking 0.3 0.6 1.1 -1.1 -0.1
Alcohol usually taken with meals 1.7 2.7 5.0 -0.7 2.2
Nervous feelings 0.1 0.2 0.5 0.7 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.1 0.3 0.1
Hearing difficulty/problems with background noise 1.4 2.2 4.3 -2.1 0.2
Hair/balding pattern: Pattern 2 1.4 1.7 2.1 1.4 -1.2
Had menopause 0.2 0.2 0.3 -0.6 0.4
Had other major operations 0.3 0.4 0.4 0.7 -0.6
Forced vital capacity (FVC) 0.1 0.2 0.4 0.1 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.6 0.3 1.6
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 3.3 1.8 1.1
Qualifications: None of the above 1.1 2.3 4.1 -2.0 0.8
Financial difficulties in last 2 years 0.1 0.2 0.2 0.5 0.4
Mouth/teeth dental problems 0.3 0.5 0.7 0.5 0.9
Heart attack 0.4 0.6 0.7 0.9 -0.6
Allergy 0.7 1.5 3.1 0.2 -1.8
Pain all over the body in last month 1.5 1.7 1.7 -1.3 1.3
Diabetes (self-reported) 1.3 2.1 3.6 0.7 1.9
Hayfever/allergic rhinitis (self-reported) 2.7 3.5 5.1 1.4 -2.3
Medication: Ramipril 1.4 1.8 2.4 -1.1 1.6
Medication: Simvastatin 0.1 0.1 0.2 -0.2 0.5
Fluid intelligence score 0.9 1.9 3.8 2.0 0.2
Illnesses of siblings 1.6 2.2 2.5 1.4 -1.6
Neuroticism score 0.4 0.8 1.5 1.2 -0.4
Weight 0.3 1.5 2.1 -0.9 1.4
Impedance of arm (right) 0.6 3.0 5.5 0.7 -2.3
Arm fat percentage (right) 0.9 3.4 6.8 -0.3 2.6
Trunk fat-free mass 0.2 1.1 1.3 -1.1 0.9
Hip circumference 0.3 1.1 2.2 -0.3 1.5
Time employed in main current job 0.4 0.4 0.6 -0.8 -0.5
Alcohol intake versus 10 years previously 1.1 1.7 3.3 -0.2 1.8
Father’s age at death 0.5 0.7 1.2 1.1 -0.4
Worrier / anxious feelings 0.5 1.0 1.7 0.6 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 0.6 0.9
Falls in the last year 3.1 4.2 7.3 -1.0 2.7
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 0.3 -0.3
Number of live births 0.7 1.0 2.0 0.2 -1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.2 0.5 0.4
Pulse rate 1.5 2.6 3.6 -1.2 1.9
Happiness 0.7 0.8 1.6 -0.3 1.3
Noisy workplace 2.4 2.9 4.6 -2.1 1.1
Qualifications: A levels/AS levels or equivalent 1.2 2.7 5.3 2.3 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 2.4 -1.6 1.2
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 -0.6 0.4
Asthma 0.1 0.2 0.4 0.2 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.0 0.6 1.0
Medication: Cholesterol lowering 0.0 0.1 0.1 -0.2 0.3
Depression (self-reported) 1.7 2.0 2.5 -1.2 1.6
Medication: Lansoprazole 0.7 0.7 1.5 1.2 0.0
Prospective memory result 1.8 2.2 2.6 -1.6 1.3
Lung cancer (father) 2.5 3.0 4.3 2.1 -1.2
Illnesses of mother 0.1 0.1 0.2 -0.1 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 2.7 -0.2 1.6
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 0.0 -0.2
Impedance of arm (left) 1.0 4.7 8.8 0.7 -3.0
Arm fat mass (right) 0.7 3.1 5.7 -0.6 2.4
Trunk predicted mass 0.2 1.2 1.4 -1.2 1.0
Standing height 0.5 4.9 8.5 -1.1 -2.9
Length of working week for main job 0.5 0.5 0.8 -0.5 -0.9
Exposure to tobacco smoke at home 0.9 1.0 2.0 0.0 -1.4
Breastfed as a baby 2.1 2.6 3.8 1.9 -1.2
Tense / ‘highly strung’ 0.1 0.1 0.2 -0.4 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.6 0.8 0.3
Hair/balding pattern: Pattern 4 1.1 2.6 3.8 -1.1 2.0
Birth weight of first child 2.1 3.9 7.6 -0.4 -2.8
Peak expiratory flow (PEF) 1.3 3.0 3.2 1.8 1.7
Pulse wave reflection index 1.8 2.2 3.8 0.8 -1.9
Ever highly irritable/argumentative for 2 days 0.6 0.7 0.9 0.9 0.7
Loud music exposure frequency 2.9 3.1 6.2 2.5 0.3
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.1 1.5 1.0
Mouth/teeth dental problems: Bleeding gums 4.0 5.1 9.2 1.1 -3.0
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.2 -0.2
Medication: Paracetamol 0.1 0.1 0.3 0.5 0.1
Headache pain in last month 0.1 0.2 0.3 -0.6 0.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 0.9 -0.1 -0.9
Glaucoma (self-reported) 2.4 2.8 3.3 -1.8 1.5
Gout (self-reported) 0.7 1.0 1.8 -1.4 0.4
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 2.4 -1.5 1.5
Medication: Amlodipine 0.5 0.7 0.7 -0.9 0.8
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.7 1.3 -0.5
Birth weight 0.5 1.2 1.5 -1.2 -0.9
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.0 -0.6 1.4
High blood pressure (siblings) 1.6 2.3 4.5 0.2 2.1
Forced vital capacity (FVC), Best measure 0.1 0.5 0.7 -0.8 0.4
Body fat percentage 0.4 1.5 3.0 0.1 1.7
Leg fat percentage (right) 0.4 1.4 2.2 0.8 1.5
Arm fat-free mass (right) 0.2 0.9 1.4 -1.2 0.6
Exposure to tobacco smoke outside home 0.3 0.4 0.9 -0.9 0.2
Comparative body size at age 10 0.0 0.0 0.1 -0.2 0.0
Number of full brothers 0.4 0.5 0.7 0.5 -0.9
Worry too long after embarrassment 1.3 2.2 2.5 1.6 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.2 0.4 0.5
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 0.1 -0.5
Number of children fathered 1.8 2.0 3.8 -2.0 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.5 0.7 0.7
Age at first live birth 0.8 1.4 1.5 1.1 -1.2
Pulse wave peak to peak time 0.0 0.0 0.0 -0.2 0.1
Health satisfaction 1.9 2.5 4.6 2.1 -0.6
Shortness of breath walking on level ground 1.7 2.0 3.2 1.8 -0.9
Qualifications: College or University degree 0.8 2.6 4.9 0.6 2.2
Eye problems/disorders: None of the above 2.9 3.3 6.1 0.8 -2.5
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 -0.2 0.5
Emphysema/chronic bronchitis 0.5 0.5 1.0 0.2 1.0
Medication for pain relief, constipation, heartburn 1.0 1.7 2.8 -1.7 -0.8
Neck or shoulder pain in last month 0.2 0.4 0.4 -0.6 0.6
Medication: Blood pressure 0.5 0.9 1.5 0.6 1.2
Angina (self-reported) 0.5 0.6 1.2 0.3 1.1
Migraine (self-reported) 0.0 0.1 0.1 0.3 0.0
Medication: Ibuprofen 0.4 0.5 0.8 0.4 0.9
Medication: Allopurinol 2.6 3.5 5.1 -2.2 1.4
Medication: Omeprazole 0.1 0.1 0.2 0.2 -0.4
Medication: Seretide 50 evohaler 4.1 4.7 7.0 -1.5 2.6
Mean time to correctly identify matches 0.6 1.2 1.8 -0.7 1.3
Heart disease (mother) 1.2 1.5 2.8 -0.5 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.2 1.5 -0.8
Whole body fat mass 0.4 1.8 3.5 -0.3 1.9
Leg fat mass (right) 0.5 1.9 3.7 -0.1 1.9
Arm predicted mass (right) 0.2 0.9 1.3 -1.2 0.6
Pulse rate, automated reading 1.3 4.2 5.0 -1.8 2.2
Alcohol intake frequency. 2.2 5.2 10.4 0.2 3.2
Comparative height size at age 10 0.3 1.7 1.8 -1.4 -1.2
Number of full sisters 0.1 0.1 0.3 -0.5 -0.1
Suffer from ‘nerves’ 0.2 0.2 0.3 -0.5 -0.4
Overall health rating 1.4 3.0 4.0 1.4 2.0
Chest pain or discomfort 0.1 0.1 0.1 0.4 0.3
Had major operations 2.2 2.5 3.6 1.9 -1.2
Age at last live birth 0.5 0.7 1.0 0.6 -1.0
Family relationship satisfaction 0.0 0.0 0.0 0.1 0.1
Leg pain on walking 0.9 1.1 2.0 -0.5 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.8 0.9 0.2
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 0.0 0.7
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.4 0.0
Medication: Aspirin 2.0 2.7 3.2 1.8 1.5
Supplements: Vitamin C 0.2 0.3 0.3 -0.5 -0.6
Knee pain experienced in last month 0.5 0.8 0.9 0.9 0.8
Hypertension (Self-reported) 3.3 9.2 16.4 -1.4 4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 1.9 0.5 -1.4
Illnesses of father: Heart disease 0.0 0.0 0.0 -0.0 0.1
Illnesses of siblings: Diabetes 3.3 4.1 6.6 -1.3 2.6
Smoking status: Previous 0.4 0.6 0.7 0.7 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.6 0.0 -1.6
Whole body fat-free mass 0.3 1.7 2.0 -1.4 1.1
Leg fat-free mass (right) 0.4 2.0 2.3 -1.5 1.2
Arm fat percentage (left) 0.7 2.9 5.8 -0.2 2.4
Average weekly red wine intake 0.2 0.3 0.4 0.6 -0.5
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.5 0.2 -1.6
Mood swings 0.8 1.4 2.3 1.5 0.7
Loneliness, isolation 1.0 1.4 2.1 0.8 1.5
Long-standing illness, disability or infirmity 2.0 3.1 6.2 0.0 2.5
Ever had bowel cancer screening 0.1 0.1 0.2 -0.0 -0.4
Diabetes diagnosed by doctor 1.4 2.2 3.9 0.7 2.0
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.1 3.0 1.7 -1.1
Friendships satisfaction 0.4 0.5 1.0 0.2 1.0
Qualifications: nursing, teaching 0.6 0.9 1.7 0.1 1.3
Commuting to job workplace: Walk 0.8 0.9 1.7 0.3 1.3
Eye problems/disorders: Cataract 4.1 4.7 9.3 -0.4 3.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 -0.5 0.2
Medication for cholesterol 3.0 4.6 8.4 0.8 -2.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.7 1.3 -0.5
Back pain experienced in last month 0.0 0.1 0.1 0.1 0.4
Mineral and other dietary supplements 0.8 1.1 1.8 0.6 -1.3
Breast cancer (self-reported) 1.1 1.4 2.4 -1.6 0.5
Asthma (self-reported) 0.2 0.3 0.6 0.3 0.8
Osteoporosis (self-reported) 9.6 11.9 13.4 -3.2 3.7
Osteoarthritis (self-reported) 0.1 0.2 0.2 -0.3 0.5
Medication: Aspirin 2.1 2.8 3.3 1.8 1.5
Medication: Gliclazide 0.0 0.0 0.0 0.1 0.1
Illnesses of father: None of the above (group 1) 1.5 1.9 2.4 1.5 -1.2
Smoking status: Current 1.0 1.5 2.8 -1.7 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.2 -0.5 1.1
Whole body water mass 0.2 1.3 1.7 -1.3 1.0
Leg predicted mass (right) 0.4 2.1 2.5 -1.6 1.3
Arm fat mass (left) 0.7 2.8 5.2 -0.5 2.3
Number of self-reported non-cancer illnesses 0.7 1.1 1.4 -0.9 1.2
Average weekly champagne plus white wine intake 0.1 0.1 0.1 -0.3 -0.2
Miserableness 2.6 4.4 6.5 2.5 -1.5
Guilty feelings 0.2 0.2 0.5 -0.7 0.0
Wears glasses or contact lenses 0.3 0.4 0.7 0.9 -0.0
Ever taken oral contraceptive pill 1.1 1.2 2.0 0.7 -1.4
Hearing aid user 0.5 0.6 1.0 1.0 -0.3
Mother’s age at death 0.9 1.1 1.5 -1.2 0.8
Financial situation satisfaction 0.2 0.3 0.4 -0.3 0.6
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.4 -0.3 0.7
Commuting to job workplace: Public transport 1.2 1.5 2.5 0.7 1.6
Eye problems/disorders: Glaucoma 2.1 2.5 3.3 -1.3 1.8
Medication: Blood pressure 3.6 6.8 13.3 -0.5 3.6
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.3 -0.7 1.2
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.2 -0.4 0.4
High cholesterol (Self-reported) 0.2 0.4 0.7 -0.8 0.4
Medication: Bendroflumethiazide 2.8 4.3 6.1 -1.6 2.5
Medication: Paracetamol 0.1 0.1 0.2 0.5 0.2
Medication: Lisinopril 1.2 1.6 2.0 1.4 1.1
Medication: Atorvastatin 0.2 0.3 0.4 -0.6 0.4
Illnesses of father: High blood pressure 2.3 2.8 4.1 -1.2 2.0
Alcohol drinker status: Never 0.6 0.7 1.3 -1.1 0.4
Ever smoked 0.0 0.1 0.2 0.4 -0.0
Basal metabolic rate 0.3 1.4 1.5 -1.2 1.1
Leg fat percentage (left) 0.5 1.7 3.2 0.5 1.8
Arm fat-free mass (left) 0.2 0.9 1.1 -1.0 0.8
Number of operations (self-reported) 1.1 1.6 1.7 1.2 -1.3
Average weekly beer plus cider intake 3.6 5.2 10.3 -0.2 -3.2
Irritability 0.6 1.1 2.1 0.3 -1.4
Risk taking 0.9 1.3 2.3 -0.6 -1.5
Ever had prostate specific antigen (PSA) test 0.5 0.6 0.6 -0.7 0.8
Fractured/broken bones in last 5 years 0.0 0.1 0.1 -0.3 -0.1
Age started oral contraceptive pill 0.4 0.4 0.9 -0.1 0.9
Diastolic blood pressure, automated reading 0.4 1.2 2.3 -1.5 0.4
Ever depressed for a whole week 2.8 3.5 5.5 1.2 2.3
Unable to work because of sickness or disability 0.2 0.2 0.3 0.4 0.5
Commuting to job workplace: Cycle 0.1 0.1 0.3 -0.5 0.1
Myopia 0.3 0.4 0.7 -0.1 -0.8
Vascular/heart problems diagnosed by doctor 2.9 7.8 14.1 1.2 -3.8
Cholesterol lowering medication 0.3 0.4 0.6 -0.5 0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.4 0.6 -0.6
Pain experienced in last month 0.0 0.1 0.1 0.1 -0.3
Supplements: Calcium 3.0 3.3 6.2 -0.7 2.5
Basal cell carcinoma (self-reported) 0.7 0.8 1.6 -1.3 0.0
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.1 1.1 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.4 0.2
Heart disease (siblings) 0.2 0.2 0.3 -0.4 -0.5
Alcohol drinker status: Previous 0.5 0.6 1.1 -0.2 1.0
Pack years of smoking 0.4 0.6 1.2 -1.1 0.2
Impedance of whole body 1.6 7.9 14.4 1.2 -3.8
Leg fat mass (left) 0.6 2.2 4.3 -0.2 2.1
Arm predicted mass (left) 0.2 0.9 0.9 -1.0 0.9