TWAS hub - KHDRBS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0280	8.3e-06	0.038	0.045	0.029	0.047	0.041	1.8e-05	3.0e-06	0.00015	1.8e-06	8.7e-06
2	TCGA	Lung Squamous Cell Carcinoma	0.0584	0.0308	6.7e-03	0.011	0.023	0.007	NA	0.010	1.9e-02	1.2e-03	0.04300	NA	2.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Osteoporosis (self-reported)	9.6	11.9	13.4	-3.2	3.7
Medication: Seretide 50 evohaler	4.1	4.7	7.0	-1.5	2.6
Eye problems/disorders: Cataract	4.1	4.7	9.3	-0.4	3.0
Mouth/teeth dental problems: Bleeding gums	4.0	5.1	9.2	1.1	-3.0
Medication: Blood pressure	3.6	6.8	13.3	-0.5	3.6
Average weekly beer plus cider intake	3.6	5.2	10.3	-0.2	-3.2
Hypertension (Self-reported)	3.3	9.2	16.4	-1.4	4.0
Illnesses of siblings: Diabetes	3.3	4.1	6.6	-1.3	2.6
Schizophrenia (2018)	3.1	6.5	10.8	-1.5	3.3
High blood pressure	3.1	8.5	14.8	-1.5	3.9
Falls in the last year	3.1	4.2	7.3	-1.0	2.7
Medication for cholesterol	3.0	4.6	8.4	0.8	-2.9
Supplements: Calcium	3.0	3.3	6.2	-0.7	2.5
Loud music exposure frequency	2.9	3.1	6.2	2.5	0.3
Eye problems/disorders: None of the above	2.9	3.3	6.1	0.8	-2.5
Vascular/heart problems diagnosed by doctor	2.9	7.8	14.1	1.2	-3.8
Medication: Bendroflumethiazide	2.8	4.3	6.1	-1.6	2.5
Ever depressed for a whole week	2.8	3.5	5.5	1.2	2.3
Hayfever/allergic rhinitis (self-reported)	2.7	3.5	5.1	1.4	-2.3
Medication: Allopurinol	2.6	3.5	5.1	-2.2	1.4
Miserableness	2.6	4.4	6.5	2.5	-1.5
Lung cancer (father)	2.5	3.0	4.3	2.1	-1.2
Number of treatments/medications taken	2.4	4.3	8.5	-0.4	2.9
Noisy workplace	2.4	2.9	4.6	-2.1	1.1
Glaucoma (self-reported)	2.4	2.8	3.3	-1.8	1.5
Illnesses of father: High blood pressure	2.3	2.8	4.1	-1.2	2.0
Alcohol intake frequency.	2.2	5.2	10.4	0.2	3.2
Had major operations	2.2	2.5	3.6	1.9	-1.2
Breastfed as a baby	2.1	2.6	3.8	1.9	-1.2
Birth weight of first child	2.1	3.9	7.6	-0.4	-2.8
Medication: Aspirin	2.1	2.8	3.3	1.8	1.5
Eye problems/disorders: Glaucoma	2.1	2.5	3.3	-1.3	1.8
Medication: Aspirin	2.0	2.7	3.2	1.8	1.5
Long-standing illness, disability or infirmity	2.0	3.1	6.2	0.0	2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	3.0	1.7	-1.1
Cardiovascular Disease	1.9	6.1	8.9	-1.8	3.0
Medication for hormone replacement therapy	1.9	2.2	3.5	-1.9	0.9
Diabetes (father)	1.9	2.3	3.8	-1.0	1.9
Age when periods started (menarche)	1.9	4.5	6.2	1.6	-2.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	3.8	-2.0	0.6
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	3.3	1.8	1.1
Health satisfaction	1.9	2.5	4.6	2.1	-0.6
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	3.7	-0.5	1.9
Prospective memory result	1.8	2.2	2.6	-1.6	1.3
Pulse wave reflection index	1.8	2.2	3.8	0.8	-1.9
Number of children fathered	1.8	2.0	3.8	-2.0	-0.5
Allergy or Eczema	1.7	4.5	6.6	-1.6	2.6
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.7	0.7	2.4
Relative age voice broke	1.7	2.7	5.3	-0.2	-2.3
Alcohol usually taken with meals	1.7	2.7	5.0	-0.7	2.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	2.4	-1.6	1.2
Depression (self-reported)	1.7	2.0	2.5	-1.2	1.6
Shortness of breath walking on level ground	1.7	2.0	3.2	1.8	-0.9
Blood Red Count	1.6	15.7	27.9	-1.9	5.3
BMI	1.6	9.3	15.3	-1.8	3.9
Illnesses of siblings	1.6	2.2	2.5	1.4	-1.6
High blood pressure (siblings)	1.6	2.3	4.5	0.2	2.1
Impedance of whole body	1.6	7.9	14.4	1.2	-3.8
Medication: Co-codamol	1.5	1.7	2.2	-1.5	1.1
Pain all over the body in last month	1.5	1.7	1.7	-1.3	1.3
Pulse rate	1.5	2.6	3.6	-1.2	1.9
Illnesses of father: None of the above (group 1)	1.5	1.9	2.4	1.5	-1.2
Schizophrenia (2014)	1.4	3.2	6.2	-0.3	2.5
Current tobacco smoking	1.4	2.3	4.4	-2.1	-0.4
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.1	1.8	-0.2
Waist circumference	1.4	5.2	10.2	-0.4	3.2
Hearing difficulty/problems with background noise	1.4	2.2	4.3	-2.1	0.2
Hair/balding pattern: Pattern 2	1.4	1.7	2.1	1.4	-1.2
Medication: Ramipril	1.4	1.8	2.4	-1.1	1.6
Overall health rating	1.4	3.0	4.0	1.4	2.0
Diabetes diagnosed by doctor	1.4	2.2	3.9	0.7	2.0
Impedance of leg (right)	1.3	6.4	11.0	1.3	-3.3
High blood pressure (mother)	1.3	1.9	3.2	-0.7	1.8
Diabetes (self-reported)	1.3	2.1	3.6	0.7	1.9
Peak expiratory flow (PEF)	1.3	3.0	3.2	1.8	1.7
Worry too long after embarrassment	1.3	2.2	2.5	1.6	-1.4
Pulse rate, automated reading	1.3	4.2	5.0	-1.8	2.2
Rheumatoid Arthritis	1.2	1.6	2.5	0.8	-1.6
Qualifications: A levels/AS levels or equivalent	1.2	2.7	5.3	2.3	-0.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	2.4	-1.5	1.5
Heart disease (mother)	1.2	1.5	2.8	-0.5	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.2	1.5	-0.8
Commuting to job workplace: Public transport	1.2	1.5	2.5	0.7	1.6
Medication: Lisinopril	1.2	1.6	2.0	1.4	1.1
Crohns Disease (2012)	1.1	1.7	3.4	-1.9	-0.1
Fasting Glucose	1.1	1.3	2.1	0.7	1.4
Triglycerides	1.1	1.8	3.2	-0.6	1.8
Chronotype (morning person)	1.1	2.5	3.0	-1.7	1.4
Body mass index (BMI)	1.1	4.7	9.2	-0.4	3.0
Impedance of leg (left)	1.1	5.3	9.4	1.1	-3.1
Qualifications: None of the above	1.1	2.3	4.1	-2.0	0.8
Alcohol intake versus 10 years previously	1.1	1.7	3.3	-0.2	1.8
Hair/balding pattern: Pattern 4	1.1	2.6	3.8	-1.1	2.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.5	0.2	-1.6
Breast cancer (self-reported)	1.1	1.4	2.4	-1.6	0.5
Ever taken oral contraceptive pill	1.1	1.2	2.0	0.7	-1.4
Number of operations (self-reported)	1.1	1.6	1.7	1.2	-1.3
Bipolar Disorder or Schizophrenia	1.0	2.5	3.9	-1.0	2.0
Alzheimer’s Disease (in father)	1.0	1.1	2.0	-0.5	1.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.3	0.3	-1.5
Lung FEV1/FVC ratio	1.0	5.3	10.2	0.6	3.2
Impedance of arm (left)	1.0	4.7	8.8	0.7	-3.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.1	1.5	1.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.0	-0.6	1.4
Medication for pain relief, constipation, heartburn	1.0	1.7	2.8	-1.7	-0.8
Loneliness, isolation	1.0	1.4	2.1	0.8	1.5
Smoking status: Current	1.0	1.5	2.8	-1.7	-0.5
Primary Biliary Cirrhosis	0.9	1.3	2.3	-0.5	1.5
Relative age of first facial hair	0.9	1.8	2.7	-0.9	-1.6
Supplements: Zinc	0.9	1.0	1.9	-0.3	1.4
Taking other prescription medications	0.9	1.3	2.5	-0.4	1.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.2	1.1	-1.0
Fluid intelligence score	0.9	1.9	3.8	2.0	0.2
Arm fat percentage (right)	0.9	3.4	6.8	-0.3	2.6
Exposure to tobacco smoke at home	0.9	1.0	2.0	0.0	-1.4
Leg pain on walking	0.9	1.1	2.0	-0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.9	0.5	-1.4
Mother’s age at death	0.9	1.1	1.5	-1.2	0.8
Risk taking	0.9	1.3	2.3	-0.6	-1.5
Smoking Status	0.8	2.0	2.6	-1.6	1.2
Medication: Levothyroxine sodium	0.8	1.3	1.7	-1.3	0.9
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.7	1.3	-0.5
Age at first live birth	0.8	1.4	1.5	1.1	-1.2
Qualifications: College or University degree	0.8	2.6	4.9	0.6	2.2
Mood swings	0.8	1.4	2.3	1.5	0.7
Commuting to job workplace: Walk	0.8	0.9	1.7	0.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.7	1.3	-0.5
Mineral and other dietary supplements	0.8	1.1	1.8	0.6	-1.3
Bipolar Disorder (2011)	0.7	0.7	1.0	-1.0	0.6
Hearing difficulty/problems: Yes	0.7	1.0	2.0	-0.2	-1.4
Systolic blood pressure, automated reading	0.7	2.0	3.1	-0.9	1.8
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.0	-0.4	1.7
Allergy	0.7	1.5	3.1	0.2	-1.8
Number of live births	0.7	1.0	2.0	0.2	-1.4
Happiness	0.7	0.8	1.6	-0.3	1.3
Medication: Lansoprazole	0.7	0.7	1.5	1.2	0.0
Arm fat mass (right)	0.7	3.1	5.7	-0.6	2.4
Gout (self-reported)	0.7	1.0	1.8	-1.4	0.4
Arm fat percentage (left)	0.7	2.9	5.8	-0.2	2.4
Arm fat mass (left)	0.7	2.8	5.2	-0.5	2.3
Number of self-reported non-cancer illnesses	0.7	1.1	1.4	-0.9	1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-0.7	1.2
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	-1.3	0.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.1	1.1	-0.9
Depressed Affect (Nagel 2018)	0.6	1.2	2.2	1.5	-0.5
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.5	1.9	0.2
Age at First Birth	0.6	0.8	1.5	-0.3	-1.2
HDL Cholesterol	0.6	1.1	2.1	-0.0	-1.5
Neuroticism (2016)	0.6	0.9	1.3	-0.7	1.1
Heel T-Score	0.6	4.6	8.4	-0.9	2.9
Lung FVC	0.6	3.2	6.4	-0.3	2.5
Neuroticism	0.6	1.5	2.1	1.5	-0.9
Sensitivity / hurt feelings	0.6	1.0	1.9	-0.4	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.6	0.3	1.6
Impedance of arm (right)	0.6	3.0	5.5	0.7	-2.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	0.9	0.9	0.7
Mean time to correctly identify matches	0.6	1.2	1.8	-0.7	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.6	0.0	-1.6
Qualifications: nursing, teaching	0.6	0.9	1.7	0.1	1.3
Alcohol drinker status: Never	0.6	0.7	1.3	-1.1	0.4
Irritability	0.6	1.1	2.1	0.3	-1.4
Leg fat mass (left)	0.6	2.2	4.3	-0.2	2.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	1.5	0.4
HbA1C	0.5	0.6	1.2	-0.0	1.1
Height	0.5	9.9	19.4	-0.6	-4.4
Waist Hip Ratio (WHR)	0.5	2.1	4.0	0.4	2.0
Respiratory disease	0.5	1.2	2.4	0.1	1.6
Medication: Metformin	0.5	0.7	0.8	0.8	0.9
Qualifications: CSEs or equivalent	0.5	0.7	1.1	1.0	-0.5
Stomach or abdominal pain in last month	0.5	0.6	0.8	0.6	-0.9
Medication: Atenolol	0.5	0.6	1.2	0.1	1.1
Father’s age at death	0.5	0.7	1.2	1.1	-0.4
Worrier / anxious feelings	0.5	1.0	1.7	0.6	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.0	0.6	1.0
Standing height	0.5	4.9	8.5	-1.1	-2.9
Length of working week for main job	0.5	0.5	0.8	-0.5	-0.9
Medication: Amlodipine	0.5	0.7	0.7	-0.9	0.8
Birth weight	0.5	1.2	1.5	-1.2	-0.9
Emphysema/chronic bronchitis	0.5	0.5	1.0	0.2	1.0
Medication: Blood pressure	0.5	0.9	1.5	0.6	1.2
Angina (self-reported)	0.5	0.6	1.2	0.3	1.1
Leg fat mass (right)	0.5	1.9	3.7	-0.1	1.9
Age at last live birth	0.5	0.7	1.0	0.6	-1.0
Knee pain experienced in last month	0.5	0.8	0.9	0.9	0.8
Hearing aid user	0.5	0.6	1.0	1.0	-0.3
Leg fat percentage (left)	0.5	1.7	3.2	0.5	1.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.6	-0.7	0.8
Alcohol drinker status: Previous	0.5	0.6	1.1	-0.2	1.0
Body Mass Index (BMI) (2010)	0.4	0.6	0.8	0.9	0.6
Coronary Artery Disease (CAD)	0.4	0.5	0.9	1.0	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	1.0	-0.1
Angina	0.4	0.6	1.1	0.2	1.0
Severe depression (siblings)	0.4	0.5	0.9	0.1	1.0
Average weekly fortified wine intake	0.4	0.4	0.7	0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	0.9	0.8	0.9
Multivitamins +/- minerals	0.4	0.5	0.9	0.9	-0.3
Sitting height	0.4	2.5	4.0	-2.0	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	-0.0	-1.0
Heart attack	0.4	0.6	0.7	0.9	-0.6
Neuroticism score	0.4	0.8	1.5	1.2	-0.4
Time employed in main current job	0.4	0.4	0.6	-0.8	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.7	-0.2	1.6
Body fat percentage	0.4	1.5	3.0	0.1	1.7
Leg fat percentage (right)	0.4	1.4	2.2	0.8	1.5
Number of full brothers	0.4	0.5	0.7	0.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.5	0.7	0.7
Medication: Ibuprofen	0.4	0.5	0.8	0.4	0.9
Whole body fat mass	0.4	1.8	3.5	-0.3	1.9
Smoking status: Previous	0.4	0.6	0.7	0.7	0.8
Leg fat-free mass (right)	0.4	2.0	2.3	-1.5	1.2
Friendships satisfaction	0.4	0.5	1.0	0.2	1.0
Leg predicted mass (right)	0.4	2.1	2.5	-1.6	1.3
Age started oral contraceptive pill	0.4	0.4	0.9	-0.1	0.9
Diastolic blood pressure, automated reading	0.4	1.2	2.3	-1.5	0.4
Pack years of smoking	0.4	0.6	1.2	-1.1	0.2
Bipolar Disorder (2018)	0.3	0.4	0.8	0.3	-0.9
Depression (Nagel 2018)	0.3	0.5	0.8	0.5	0.9
Neuroticism (Nagel 2018)	0.3	0.8	0.8	0.9	-0.9
Alzheimer’s Disease (including proxy)	0.3	0.5	0.8	0.3	0.9
Major Depression (MDD)	0.3	0.4	0.4	-0.6	0.6
Breast Cancer	0.3	0.8	1.5	-0.4	1.2
Mean Putamen Volume	0.3	0.3	0.5	-0.3	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.4	0.5	0.6
Pack years adult smoking proportion	0.3	0.5	0.9	-1.0	-0.3
Leg fat-free mass (left)	0.3	1.5	1.8	-1.3	1.1
Hand grip strength (right)	0.3	0.9	1.3	-1.1	-0.7
Supplements: Glucosamine	0.3	0.4	0.7	0.2	0.8
Leg predicted mass (left)	0.3	1.4	1.6	-1.3	1.1
Past tobacco smoking	0.3	0.6	1.1	-1.1	-0.1
Had other major operations	0.3	0.4	0.4	0.7	-0.6
Mouth/teeth dental problems	0.3	0.5	0.7	0.5	0.9
Weight	0.3	1.5	2.1	-0.9	1.4
Hip circumference	0.3	1.1	2.2	-0.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.9	-0.1	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.9	0.2
Comparative height size at age 10	0.3	1.7	1.8	-1.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	0.9	0.2
Whole body fat-free mass	0.3	1.7	2.0	-1.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.2	-0.5	1.1
Wears glasses or contact lenses	0.3	0.4	0.7	0.9	-0.0
Basal metabolic rate	0.3	1.4	1.5	-1.2	1.1
Myopia	0.3	0.4	0.7	-0.1	-0.8
Cholesterol lowering medication	0.3	0.4	0.6	-0.5	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.4	0.6	-0.6
Ovarian Cancer	0.2	0.2	0.3	-0.6	-0.4
LDL Cholesterol	0.2	0.3	0.4	-0.6	0.5
Lupus	0.2	0.4	0.6	-0.3	-0.8
Systolic Blood Pressure	0.2	0.8	1.6	-0.3	1.2
Hypothyroidism (self reported)	0.2	0.4	0.5	-0.6	0.7
Hand grip strength (left)	0.2	0.4	0.7	-0.8	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.2	-0.5	0.5
Diabetes (mother)	0.2	0.2	0.4	-0.2	0.6
Trunk fat percentage	0.2	0.8	1.5	-0.1	1.2
Trunk fat mass	0.2	0.9	1.7	-0.4	1.3
Had menopause	0.2	0.2	0.3	-0.6	0.4
Trunk fat-free mass	0.2	1.1	1.3	-1.1	0.9
Trunk predicted mass	0.2	1.2	1.4	-1.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	0.8	0.3
Arm fat-free mass (right)	0.2	0.9	1.4	-1.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.2	0.4	0.5
Neck or shoulder pain in last month	0.2	0.4	0.4	-0.6	0.6
Arm predicted mass (right)	0.2	0.9	1.3	-1.2	0.6
Suffer from ‘nerves’	0.2	0.2	0.3	-0.5	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	0.0	0.7
Supplements: Vitamin C	0.2	0.3	0.3	-0.5	-0.6
Average weekly red wine intake	0.2	0.3	0.4	0.6	-0.5
Asthma (self-reported)	0.2	0.3	0.6	0.3	0.8
Whole body water mass	0.2	1.3	1.7	-1.3	1.0
Guilty feelings	0.2	0.2	0.5	-0.7	0.0
Financial situation satisfaction	0.2	0.3	0.4	-0.3	0.6
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.3	0.7
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.8	0.4
Medication: Atorvastatin	0.2	0.3	0.4	-0.6	0.4
Arm fat-free mass (left)	0.2	0.9	1.1	-1.0	0.8
Unable to work because of sickness or disability	0.2	0.2	0.3	0.4	0.5
Heart disease (siblings)	0.2	0.2	0.3	-0.4	-0.5
Arm predicted mass (left)	0.2	0.9	0.9	-1.0	0.9
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	0.2
Ulcerative Colitis (UC)	0.1	0.1	0.1	-0.3	0.4
Reaction Time	0.1	0.2	0.4	-0.2	0.6
Blood Eosinophil Count	0.1	0.8	1.3	-0.5	1.2
Blood Platelet Count	0.1	1.4	2.8	0.2	1.7
Blood White Count	0.1	0.9	1.3	-0.7	1.1
Average weekly spirits intake	0.1	0.1	0.3	-0.2	0.5
Ever had hysterectomy (womb removed)	0.1	0.2	0.2	0.5	-0.3
Vitamin and mineral supplements	0.1	0.1	0.3	-0.0	-0.5
Maternal smoking around birth	0.1	0.2	0.3	0.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.0	0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.3	0.3
Nervous feelings	0.1	0.2	0.5	0.7	0.2
Forced vital capacity (FVC)	0.1	0.2	0.4	0.1	-0.7
Financial difficulties in last 2 years	0.1	0.2	0.2	0.5	0.4
Medication: Simvastatin	0.1	0.1	0.2	-0.2	0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.2	0.5	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.6	0.4
Asthma	0.1	0.2	0.4	0.2	0.6
Illnesses of mother	0.1	0.1	0.2	-0.1	-0.5
Tense / ‘highly strung’	0.1	0.1	0.2	-0.4	-0.2
Medication: Paracetamol	0.1	0.1	0.3	0.5	0.1
Headache pain in last month	0.1	0.2	0.3	-0.6	0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	0.7	-0.8	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	0.5
Medication: Omeprazole	0.1	0.1	0.2	0.2	-0.4
Number of full sisters	0.1	0.1	0.3	-0.5	-0.1
Chest pain or discomfort	0.1	0.1	0.1	0.4	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.4	0.0
Ever had bowel cancer screening	0.1	0.1	0.2	-0.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.5	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.2	-0.3	0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.2	-0.4	0.4
Medication: Paracetamol	0.1	0.1	0.2	0.5	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	0.2
Worry (Nagel 2018)	0.0	0.0	0.1	0.2	-0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.0	0.2
Crohns Disease (2017)	0.0	0.1	0.1	-0.2	-0.3
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.2	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.1	-0.3	-0.0
Hair Pigment	0.0	0.5	0.9	0.3	-1.0
Tanning	0.0	0.3	0.4	-0.6	-0.3
Townsend deprivation index at recruitment	0.0	0.1	0.1	-0.2	-0.3
Fed-up feelings	0.0	0.0	0.1	0.2	0.2
Number of incorrect matches in round	0.0	0.1	0.1	-0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.3	0.1
Medication: Cholesterol lowering	0.0	0.1	0.1	-0.2	0.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.0	-0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.2	-0.2
Comparative body size at age 10	0.0	0.0	0.1	-0.2	0.0
Pulse wave peak to peak time	0.0	0.0	0.0	-0.2	0.1
Migraine (self-reported)	0.0	0.1	0.1	0.3	0.0
Family relationship satisfaction	0.0	0.0	0.0	0.1	0.1
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.0	0.1
Back pain experienced in last month	0.0	0.1	0.1	0.1	0.4
Medication: Gliclazide	0.0	0.0	0.0	0.1	0.1
Ever smoked	0.0	0.1	0.2	0.4	-0.0
Fractured/broken bones in last 5 years	0.0	0.1	0.1	-0.3	-0.1
Pain experienced in last month	0.0	0.1	0.1	0.1	-0.3

Hub : Genes

KHDRBS2

Models

Trait associations