Hub : Genes

KIAA0040

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1330	0.0320	2.1e-08	0.063	0.079	0.078	0.086	0.096	3.6e-08	6.8e-10	9.4e-10	1.3e-10	8.8e-12
2	GTEx	Adipose Subcutaneous	0.0880	0.0360	5.5e-03	0.070	NA	0.056	NA	0.059	2.2e-06	NA	2.3e-05	NA	1.4e-05
3	GTEx	Artery Aorta	0.3210	0.0790	1.1e-04	0.216	NA	0.191	NA	0.209	4.1e-12	NA	9.4e-11	NA	9.4e-12
4	GTEx	Artery Tibial	0.1163	0.0468	3.7e-03	0.001	NA	0.022	NA	0.011	2.7e-01	NA	7.1e-03	NA	3.9e-02
5	GTEx	Skin Sun Exposed Lower leg	0.0990	0.0320	8.1e-05	0.062	NA	0.032	NA	0.027	7.8e-06	NA	1.2e-03	NA	2.3e-03
6	GTEx	Thyroid	0.1960	0.0710	6.7e-03	0.080	NA	0.042	NA	0.060	1.1e-06	NA	3.8e-04	NA	2.3e-05
7	METSIM	Adipose	0.1902	0.0413	7.3e-13	0.053	0.094	0.099	0.091	0.101	1.9e-08	6.1e-14	1.2e-14	1.6e-13	6.6e-15
8	YFS	Blood	0.3908	0.0381	0.0e+00	0.314	0.366	0.410	0.405	0.415	1.5e-105	2.5e-127	9.4e-147	1.4e-144	4.6e-149
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0643	0.0289	6.3e-04	0.003	0.028	0.019	NA	0.013	1.4e-01	3.9e-04	3.0e-03	NA	1.2e-02
10	TCGA	Prostate Adenocarcinoma	0.0319	0.0159	3.2e-03	0.012	0.015	0.006	NA	0.007	1.8e-02	9.8e-03	7.2e-02	NA	5.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	2.2	3.4	16.4	4.1	0.7	-1.4	2.3	0.7	-0.8	0.8	0.2	2.0	-2.1
Bipolar Disorder or Schizophrenia	1.1	2.7	13.1	3.6	-1.0	0.8	2.1	-1.4	1.3	-0.6	-1.4	1.5	-0.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.8	1.0	1.2	-0.7	1.4	-1.2	-0.9	0.5	-0.1	0.6	-0.3
Depression (Nagel 2018)	1.1	1.7	3.6	1.6	1.9	-1.8	0.7	-0.4	-1.8	1.5	-0.2	0.6	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.7	-1.7	0.3	0.1	-2.1	2.2	-0.0	-0.6	0.7	-1.1	-0.6
Neuroticism (Nagel 2018)	0.3	0.7	2.3	1.2	0.4	-0.5	1.2	-1.5	-0.5	0.8	-0.4	0.0	-0.6
Schizophrenia (2018)	1.5	3.0	5.7	1.4	-1.8	2.2	0.9	-2.4	2.4	-1.3	-2.0	0.3	1.6
Schizophrenia vs Biploar Disorder	1.3	1.7	5.0	1.3	0.4	0.8	-0.0	-1.7	-0.2	1.5	-2.2	1.6	1.2
Worry (Nagel 2018)	0.7	1.4	5.7	1.5	-0.0	-1.1	1.5	-2.4	-1.1	0.5	-0.8	0.1	-0.5
Alzheimer’s Disease (in mother)	0.8	0.9	3.4	0.1	-0.3	0.5	1.8	-0.3	1.9	-0.8	0.8	0.7	-0.8
Alzheimer’s Disease (in father)	0.7	0.7	1.9	0.9	0.4	-0.4	1.4	-1.0	0.1	-0.7	-0.5	1.0	1.1
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	0.9	-0.4	0.7	1.9	-1.0	2.0	-1.2	-0.1	1.1	0.4
Crohns Disease (2017)	0.3	0.6	1.9	-0.4	0.1	0.2	0.8	0.5	0.6	0.1	1.4	1.2	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.6	-1.3	1.0	0.2	-0.2	0.6	0.5	0.3	0.7	0.2	-0.7
Ulcerative Colitis (UC)	0.4	0.7	2.9	-1.3	1.7	-0.0	-0.7	0.8	0.3	0.6	0.2	-0.4	-0.7
Major Depression (MDD)	0.3	0.3	1.1	0.2	-0.5	-0.8	0.5	-0.2	-0.4	-0.2	1.1	0.3	-0.6
Reaction Time	1.6	3.0	12.7	0.6	1.1	-3.5	0.7	1.1	-3.6	-1.0	-1.0	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.4	-0.6	0.7	-0.3	-1.2	2.1	-0.1	-0.5	0.3	-1.0	-0.8
Breast Cancer	0.4	1.1	2.8	0.7	0.2	-0.3	1.1	1.6	0.4	0.5	1.7	1.1	-1.4
Ovarian Cancer	0.2	0.3	1.3	-0.2	-0.6	0.1	-0.2	0.6	0.0	0.1	1.0	0.1	-1.1
Prostate Cancer	0.6	0.9	3.4	0.6	-0.5	-1.8	-0.1	0.3	-1.5	-0.8	0.7	0.3	-1.2
Age at First Birth	0.9	1.3	3.7	-0.4	-1.8	1.8	0.2	-0.8	1.2	-1.9	-0.3	-0.0	0.1
Bipolar Disorder (2011)	0.7	0.7	3.0	1.2	0.5	-0.3	0.6	0.7	-0.5	0.3	0.7	1.7	-0.7
Body Mass Index (BMI) (2010)	1.1	1.6	7.6	-0.3	1.4	1.0	-0.1	2.8	0.9	1.4	1.1	0.6	-0.9
Coronary Artery Disease (CAD)	1.0	1.2	3.0	-0.3	0.7	-1.4	-1.4	1.7	-1.2	0.2	0.9	-1.4	-0.6
Crohns Disease (2012)	0.2	0.4	1.9	0.3	-0.1	-0.3	0.5	-1.4	-0.1	-0.9	-0.2	0.3	0.6
Mean Putamen Volume	0.9	1.0	2.4	-1.0	0.4	0.8	-0.2	1.3	1.5	0.2	1.6	0.0	-1.4
Fasting Glucose	0.3	0.4	1.8	0.3	0.3	0.4	-0.5	1.0	-0.3	0.3	0.4	0.3	-1.3
HbA1C	0.9	1.0	2.3	1.2	0.4	-1.1	0.1	1.0	-1.5	1.2	0.1	0.5	-1.4
HDL Cholesterol	0.3	0.6	1.6	0.1	0.8	-0.9	-0.1	-1.3	-1.0	-0.3	-1.1	-0.5	0.5
LDL Cholesterol	0.6	1.0	3.8	-0.5	-1.9	1.1	-0.5	0.9	1.1	-0.8	1.0	-0.1	-1.0
Lupus	0.9	1.3	4.6	0.1	-2.1	0.8	-0.1	-1.8	1.0	-1.4	-0.1	-0.6	1.1
Neuroticism (2016)	0.5	0.7	2.2	-0.6	0.4	0.3	1.1	-1.4	1.5	0.1	-0.5	-0.3	0.9
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.6	0.3	-0.2	0.2	-0.6	-0.2	-0.3	-0.6	-0.2	-0.1
Rheumatoid Arthritis	1.4	2.0	8.4	0.9	1.4	-2.8	-0.2	-0.1	-2.9	0.4	-0.5	-0.5	-0.6
Schizophrenia (2014)	1.2	2.6	7.4	2.7	-0.8	1.3	1.7	-1.9	1.6	-0.0	-2.0	1.5	0.6
Triglycerides	0.7	1.1	4.8	0.3	-2.2	1.5	-0.2	-0.5	1.4	-0.8	0.4	0.8	0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	-1.6	0.6	0.6	-0.5	-0.2	0.6	0.0	-0.7	-1.3	1.0
Ulcerative Colitis	0.2	0.3	0.9	-0.3	0.7	-0.4	0.1	-0.8	-0.3	-0.5	-1.0	-0.1	0.1
Blood Eosinophil Count	0.3	2.2	8.5	2.9	0.4	-0.6	0.9	0.4	-1.4	2.3	-1.0	1.8	-0.4
Blood Platelet Count	0.4	5.1	11.8	2.8	1.2	0.1	2.1	2.5	0.6	2.7	2.2	3.4	-2.4
Blood Red Count	0.6	5.5	20.5	4.5	2.0	0.7	2.3	-1.8	0.3	1.9	-2.2	3.4	0.9
Blood White Count	0.2	1.6	8.4	2.9	-0.2	0.2	-0.1	1.1	-0.3	1.5	0.4	2.1	-0.4
Heel T-Score	0.3	2.0	5.6	-1.4	-2.1	-1.7	0.9	-0.2	-0.2	-2.4	1.1	-1.1	-1.6
BMI	0.4	2.6	12.8	-1.0	1.3	0.6	-0.5	3.6	0.6	1.8	1.9	-0.4	-1.6
Height	0.1	1.2	6.4	0.3	-2.5	0.6	0.2	0.7	0.6	-1.9	-0.3	-0.7	0.3
Waist Hip Ratio (WHR)	0.6	2.5	15.0	0.8	-3.9	1.3	-0.8	-2.1	0.0	-1.2	-0.5	0.8	0.7
Systolic Blood Pressure	0.1	0.7	2.7	0.1	-0.6	0.7	0.1	1.6	0.6	0.1	1.4	1.0	-0.9
Smoking Status	0.1	0.2	0.7	0.8	-0.2	-0.1	-0.1	-0.6	-0.7	0.8	-0.3	0.3	-0.1
Allergy or Eczema	0.0	0.1	0.7	-0.1	0.8	-0.2	-0.5	-0.1	-0.3	0.3	-0.3	-0.2	0.2
Cardiovascular Disease	1.0	3.4	11.6	0.9	-0.3	0.1	0.3	3.2	0.7	1.4	3.4	1.1	-2.7
Hypothyroidism (self reported)	0.4	0.9	2.8	1.7	0.2	-0.7	1.3	0.1	-1.0	-0.9	-0.5	1.2	-0.4
Respiratory disease	1.3	3.0	6.3	2.4	1.6	-0.3	2.5	1.3	0.3	1.8	1.8	1.8	-1.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.5	0.6	-1.2	1.6	1.9	-0.7	1.7	-1.5	-0.1	1.3	-0.1
Lung FEV1/FVC ratio	1.5	7.7	24.6	-1.2	0.6	1.5	-0.5	5.0	2.0	2.6	4.2	0.0	-4.5
Lung FVC	0.6	3.2	9.8	-3.1	-0.9	0.5	-1.9	1.4	0.9	0.3	2.9	-2.3	-0.8
Neuroticism	0.3	0.8	3.1	0.9	0.5	-1.0	0.7	-1.8	-0.9	0.4	-0.7	-0.5	0.2
Chronotype (morning person)	0.4	1.0	3.0	0.6	0.1	0.4	1.5	1.1	0.6	0.9	1.3	0.3	-1.7
Hair Pigment	0.0	1.0	4.9	0.8	0.6	-0.8	2.2	0.1	0.1	-0.5	1.3	0.9	-0.6
Tanning	0.0	0.5	1.6	0.3	0.1	1.2	1.1	0.8	1.0	0.2	0.2	0.6	0.2
Hand grip strength (left)	0.4	1.1	3.3	-1.8	-1.1	1.1	-0.4	0.5	1.5	-0.5	1.1	-1.1	-0.2
Number of treatments/medications taken	1.1	1.9	5.5	2.1	1.6	-0.9	2.3	-0.2	0.0	0.7	0.1	1.8	-1.5
Average weekly spirits intake	0.8	1.0	2.4	-1.2	1.6	1.4	0.5	-0.2	1.5	-0.1	-0.5	-0.4	1.1
Sensitivity / hurt feelings	0.5	0.9	3.9	-0.1	-2.0	1.1	-0.1	-1.4	1.0	-0.2	-0.1	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.6	1.0	1.0	-0.1	0.2	-0.6	0.0	1.2	-0.4	0.7	-0.3
Hearing difficulty/problems: Yes	1.2	1.8	5.7	-2.4	-1.6	0.8	-1.9	0.8	0.5	-0.9	1.0	-1.8	-0.3
Relative age of first facial hair	0.5	1.1	4.8	-0.2	0.4	0.6	0.7	2.2	1.0	1.1	1.6	0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	-1.0	1.1	-0.7	-0.5	0.4	0.0	-0.4	0.8	-0.7	-0.4
Ever used hormone-replacement therapy (HRT)	2.6	3.4	6.8	-2.6	-2.4	1.5	-1.7	-1.2	1.4	-2.2	-0.4	-1.3	2.4
Ever had hysterectomy (womb removed)	1.6	1.8	4.8	2.2	1.7	-0.4	1.9	-0.9	-0.1	1.6	-0.9	1.6	-0.2
Systolic blood pressure, automated reading	0.5	1.5	3.7	-1.2	-0.9	1.9	-0.4	-0.9	1.6	-1.7	-0.7	-0.2	1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.0	1.4	-0.2	-1.1	0.5	0.0	-1.1	-0.1	-0.1	0.1	-0.3
Angina	1.3	1.7	5.0	-0.2	0.5	-0.3	0.7	2.2	0.6	1.3	2.1	-0.1	-2.2
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.4	-0.5	-0.8	-0.4	-0.0	-0.9	0.4	0.4	-0.2	0.6
Vitamin and mineral supplements	0.4	0.6	2.5	-0.5	-0.1	0.2	0.3	0.9	0.5	0.9	1.6	0.0	-1.0
Supplements: Zinc	1.1	1.2	4.0	-0.0	1.7	-2.0	-0.4	1.2	-1.5	0.5	-0.4	-0.7	-0.8
Medication: Co-codamol	0.6	0.7	2.2	0.5	-0.4	-1.1	1.5	-1.3	-0.5	-1.1	-0.6	-0.1	0.1
Medication: Metformin	2.0	2.8	5.0	0.4	-2.1	2.2	0.8	-1.9	1.8	-2.2	-1.7	0.8	1.4
Diabetes (father)	1.1	1.3	5.3	-2.3	-0.7	1.5	-1.0	-0.2	1.1	-1.5	-0.0	-0.4	0.7
Diabetes (mother)	0.9	1.2	2.9	-0.7	1.2	-1.3	-0.5	-0.1	-1.4	-0.6	-1.7	-0.9	1.4
Severe depression (siblings)	0.5	0.5	1.3	-1.1	0.8	1.0	0.3	-0.2	0.9	-0.8	-0.5	-0.1	0.5
Pack years adult smoking proportion	0.5	0.7	2.8	1.2	0.8	0.3	1.7	0.1	0.7	0.6	0.1	1.0	-0.6
Impedance of leg (right)	1.1	5.4	15.3	0.7	-3.4	1.2	-1.2	-3.9	0.2	-2.4	-3.3	-0.3	2.6
Leg fat-free mass (left)	0.5	2.9	11.4	-0.8	1.2	0.1	0.8	3.4	1.0	1.4	2.8	0.0	-1.9
Trunk fat percentage	0.1	0.5	1.4	0.3	-0.9	1.2	-0.8	0.7	0.8	0.4	-0.2	0.4	0.4
Hand grip strength (right)	0.7	1.8	5.5	-2.4	-0.4	-0.1	-0.6	1.5	0.7	-0.4	2.3	-1.6	-0.9
Townsend deprivation index at recruitment	0.9	1.3	3.8	0.4	-0.9	-1.7	-1.5	-0.5	-1.9	-0.6	-0.6	-1.2	0.6
Current tobacco smoking	0.4	0.6	2.1	0.7	-0.2	-1.1	0.8	0.7	-1.0	-0.1	0.4	0.6	-1.5
Average weekly fortified wine intake	0.6	0.7	2.0	-1.4	-0.4	0.7	-0.8	-1.0	0.8	-0.5	0.2	-1.0	0.6
Maternal smoking around birth	1.0	1.5	3.2	-1.3	-0.9	0.8	-1.4	-1.8	0.8	-0.2	-1.4	-1.5	1.2
Fed-up feelings	0.2	0.4	1.6	1.3	0.0	0.5	0.3	-1.1	0.3	0.1	-0.3	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	4.0	1.8	1.9	-1.8	0.8	0.2	-1.9	2.0	0.3	0.7	-1.8
Relative age voice broke	0.3	0.5	2.0	-0.3	-0.0	-0.6	-0.7	1.3	0.0	0.3	1.4	-0.3	-0.7
Taking other prescription medications	0.3	0.5	1.2	1.1	0.7	0.0	0.8	-1.0	0.0	0.6	-0.6	0.9	0.4
Age when periods started (menarche)	0.2	0.5	2.2	-0.3	-0.1	1.1	0.4	-0.5	1.5	-0.0	0.8	0.6	-0.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.2	1.4	1.8	-0.2	1.7	-0.2	0.6	1.5	0.2	0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.0	-0.3	-1.3	-1.3	-0.8	-0.6	-1.7	-1.3	-0.7	-1.1	0.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.4	1.2	-0.6	0.5	-0.2	-0.1	0.7	0.1	-0.5	0.0	0.5
Qualifications: CSEs or equivalent	1.5	2.0	4.1	-0.2	1.7	-1.4	-0.9	2.0	-1.0	1.9	1.6	-0.2	-1.8
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.7	-0.4	-0.9	-0.4	0.1	-0.4	-0.9	0.1	-0.8	0.2
High blood pressure	0.2	0.6	2.4	0.2	-1.0	0.7	-0.1	1.5	0.7	-0.7	1.1	0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.1	0.7	-0.7	-0.4	0.6	-0.9	0.5	0.1	0.0	-0.8
Multivitamins +/- minerals	0.6	0.8	2.3	1.1	0.3	0.3	0.8	-0.9	-0.1	-0.9	-1.5	0.7	1.1
Stomach or abdominal pain in last month	1.3	1.6	5.1	0.4	1.3	0.1	1.4	2.3	0.5	2.1	0.9	-0.4	-1.2
Supplements: Glucosamine	1.0	1.2	3.5	0.7	1.9	-0.8	1.1	-1.3	-1.0	0.3	-1.7	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.0	-0.1	0.0	-0.2	1.2	0.2	1.1	0.8	-0.1	-1.1
Medication: Atenolol	1.1	1.4	4.4	0.1	2.1	-1.6	0.7	1.2	-1.4	1.4	0.5	0.6	-0.9
Medication: Levothyroxine sodium	0.2	0.3	1.6	0.4	-0.2	-0.4	-0.2	0.0	-1.3	-0.6	0.2	0.7	0.2
Sitting height	0.2	1.5	5.0	0.8	-2.2	1.1	1.0	-0.3	1.4	-2.0	0.6	0.4	-0.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	0.9	0.8	-1.1	0.1	0.0	-0.7	0.6	0.5	-0.0	-0.5
High blood pressure (mother)	0.2	0.3	1.6	-0.1	-0.6	1.3	0.0	0.1	0.8	-0.2	-0.7	-0.3	-0.4
Body mass index (BMI)	0.2	1.0	4.4	-0.5	1.0	0.8	0.3	2.1	1.0	1.0	1.1	0.4	-0.5
Impedance of leg (left)	1.1	5.5	15.4	1.1	-3.3	0.8	-1.6	-3.9	-0.4	-2.1	-3.6	-0.7	2.6
Leg predicted mass (left)	0.5	2.8	11.2	-0.8	1.2	0.2	0.7	3.3	1.2	1.4	2.7	-0.0	-1.8
Trunk fat mass	0.1	0.4	1.6	-0.0	-0.6	1.0	-0.5	1.2	0.9	0.4	0.4	0.2	0.1
Waist circumference	0.1	0.4	1.2	0.1	-0.4	1.1	-0.1	0.9	0.8	0.5	0.6	0.6	-0.1
Number of incorrect matches in round	0.7	1.1	3.4	1.8	-0.8	-0.9	1.1	-0.7	-1.0	-0.8	-1.2	1.1	-0.4
Past tobacco smoking	0.3	0.5	1.3	0.5	-0.2	-1.0	0.2	1.1	-0.8	-0.9	0.4	0.6	-0.7
Alcohol usually taken with meals	1.5	2.4	9.3	-3.0	-1.1	0.5	-2.3	0.9	0.2	-1.8	0.3	-1.6	0.7
Nervous feelings	1.3	2.5	6.8	1.8	1.1	-2.6	1.0	-0.5	-2.3	1.6	0.2	0.3	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.8	1.6	0.6	-1.3	0.4	-0.9	-1.4	1.7	0.2	0.1	-1.4
Hearing difficulty/problems with background noise	1.1	1.8	4.4	-1.4	-0.9	-0.1	-0.9	1.8	1.1	0.1	2.1	-1.7	-1.5
Hair/balding pattern: Pattern 2	0.7	0.8	2.7	-1.7	-0.5	0.7	-1.6	0.2	0.4	0.2	0.1	-1.1	1.0
Had menopause	1.3	1.6	3.7	-1.9	-1.6	0.1	-1.4	-0.7	0.2	-1.8	-0.2	-1.2	1.7
Had other major operations	0.5	0.6	3.1	0.6	0.1	0.8	0.7	-0.3	0.1	1.1	-0.2	1.8	-0.5
Forced vital capacity (FVC)	0.4	1.4	4.5	-1.2	-0.7	0.8	-1.0	1.3	0.9	0.7	2.1	-1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	5.1	0.0	-1.0	-1.7	-0.7	-1.1	-2.3	-1.6	-1.0	-0.9	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	0.9	1.2	-0.7	0.8	-0.0	-0.9	1.5	-0.3	0.7	-0.2
Qualifications: None of the above	1.9	4.1	12.7	3.4	0.5	0.1	3.6	-1.3	0.3	1.2	0.1	3.5	-1.0
Financial difficulties in last 2 years	2.5	3.3	8.8	2.6	1.5	0.3	3.0	0.3	0.4	1.3	1.0	3.0	-1.8
Mouth/teeth dental problems	0.8	1.3	3.1	-1.3	0.8	-0.7	-1.5	1.2	-1.3	0.0	-0.9	-1.8	1.0
Heart attack	2.3	2.9	8.2	-0.5	1.9	-0.7	0.9	2.9	-0.2	2.8	2.1	0.2	-1.8
Allergy	0.5	1.2	2.7	-0.9	-0.9	-0.4	-1.0	-1.0	-0.5	-1.1	-1.2	-1.5	1.6
Pain all over the body in last month	0.8	0.8	3.0	1.7	0.1	0.5	1.5	-0.7	1.0	0.2	0.1	1.1	-0.0
Diabetes (self-reported)	0.4	0.5	1.6	1.2	-0.1	0.4	1.3	-0.5	0.6	-0.5	-0.4	1.0	0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.8	1.9	-0.8	0.5	0.5	-0.4	0.1	0.4	0.6	0.8	-0.8
Medication: Ramipril	0.4	0.5	1.3	0.7	0.7	-1.2	-0.2	1.0	-1.1	0.3	0.6	0.2	-0.2
Medication: Simvastatin	1.1	1.7	4.7	0.8	0.8	0.1	1.6	1.6	1.3	0.6	2.2	1.2	-1.7
Fluid intelligence score	1.1	2.4	5.9	-2.4	-0.6	0.2	-2.3	1.5	0.9	-1.7	0.2	-2.4	0.4
Illnesses of siblings	0.5	0.6	1.8	0.3	1.0	-0.8	-0.8	0.3	-1.3	1.1	-0.8	-0.4	-0.1
Neuroticism score	0.3	0.5	2.2	0.9	-0.3	-0.5	0.2	-1.5	-0.7	1.0	-0.1	-0.2	-0.5
Weight	0.3	1.3	6.8	-0.7	0.4	0.5	0.3	2.6	1.0	0.5	1.8	-0.1	-1.0
Impedance of arm (right)	0.4	1.7	4.6	1.2	-2.1	-0.6	-1.3	-1.5	-1.6	-0.8	-1.7	-0.4	0.6
Arm fat percentage (right)	0.1	0.3	2.0	0.0	0.0	0.4	-0.7	1.4	0.2	0.7	0.2	-0.1	-0.1
Trunk fat-free mass	0.3	1.7	6.1	-1.4	0.6	0.2	0.9	2.5	1.3	-0.1	2.1	-1.0	-1.0
Hip circumference	0.3	1.1	5.8	-0.3	1.1	0.5	0.2	2.4	0.9	1.0	1.2	0.2	-0.5
Time employed in main current job	0.3	0.3	1.2	0.4	1.1	-0.3	1.0	0.0	-0.1	0.4	-0.2	0.4	-0.6
Alcohol intake versus 10 years previously	0.8	1.1	2.8	0.4	-1.3	1.3	1.0	1.2	0.9	-0.1	1.1	1.7	-0.8
Father’s age at death	3.3	4.5	13.7	-2.0	-2.9	0.9	-2.2	-1.8	1.2	-3.7	-0.8	-1.6	2.1
Worrier / anxious feelings	0.1	0.2	0.6	0.1	0.3	-0.6	-0.4	-0.8	-0.4	-0.0	0.1	-0.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	7.1	2.7	0.2	-0.4	0.8	-1.4	-1.0	1.7	-1.0	1.2	-0.8
Falls in the last year	1.6	2.2	5.2	0.1	0.4	0.8	1.4	2.0	1.1	2.3	2.0	1.1	-1.8
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	0.1	-1.0	-0.4	-0.0	0.8	-0.6	-0.4	0.6	0.8	-1.1
Number of live births	0.6	0.9	2.2	-1.2	1.1	0.5	-0.2	1.4	0.6	1.5	1.2	0.3	-0.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	9.2	-1.7	-0.3	1.3	-1.5	2.8	1.7	1.8	3.0	-1.6	-1.9
Pulse rate	2.0	3.4	12.3	0.2	-0.9	1.7	-0.7	-3.5	1.0	-1.2	-3.0	0.2	2.5
Happiness	0.7	0.8	2.5	0.8	1.6	-0.9	-0.2	0.9	-1.2	1.4	-0.3	0.2	-0.0
Noisy workplace	0.4	0.5	2.4	0.5	-0.3	0.3	0.6	0.2	0.7	-0.5	1.6	0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	0.2	0.1	1.5	-0.4	-0.4	1.1	0.0	-1.1	-0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.2	-0.2	0.4	-0.2	-0.4	0.3	0.7	0.3	-0.2	-0.0
Mouth/teeth dental problems: Dentures	1.1	1.9	5.9	0.1	-0.8	1.4	1.4	-1.6	2.4	-1.6	1.1	1.5	0.1
Asthma	0.8	1.5	4.5	2.1	0.6	0.3	1.9	-0.4	0.2	1.1	0.7	1.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	3.2	1.8	-0.6	1.2	1.5	-1.2	1.4	0.5	-0.6	1.8	0.0
Medication: Cholesterol lowering	1.1	1.8	3.9	0.7	1.1	-1.5	1.1	2.0	-0.7	0.9	1.7	0.8	-1.9
Depression (self-reported)	1.5	1.8	6.4	1.2	-1.8	1.3	0.7	-2.5	1.1	-1.2	-1.0	0.4	1.2
Medication: Lansoprazole	0.3	0.3	1.0	-1.0	0.7	0.2	-0.7	-0.1	0.7	0.0	0.5	-0.1	-0.5
Prospective memory result	0.5	0.7	2.6	1.6	0.1	-0.8	1.3	-0.6	-0.7	-0.2	-0.7	0.5	0.1
Lung cancer (father)	0.7	0.8	2.8	1.7	0.3	-1.3	-0.5	0.4	-1.5	0.5	-0.4	0.1	0.2
Illnesses of mother	0.8	1.0	2.7	0.9	1.4	-0.8	1.6	0.9	-0.2	0.7	1.2	0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	13.1	-3.2	-0.2	0.9	-2.0	3.6	1.5	1.2	3.4	-2.1	-2.0
Pulse wave Arterial Stiffness index	1.5	1.7	3.6	-1.9	-1.6	1.1	-1.6	-0.6	-0.1	-1.9	-1.0	-1.1	1.1
Impedance of arm (left)	0.2	1.2	3.0	1.6	-1.7	-0.5	-0.9	-1.2	-1.2	-0.1	-1.4	0.2	0.2
Arm fat mass (right)	0.1	0.6	3.0	-0.3	-0.2	1.0	-0.3	1.7	1.0	0.7	0.7	-0.0	-0.1
Trunk predicted mass	0.3	1.6	5.5	-1.5	0.5	0.1	0.7	2.3	1.3	-0.1	1.9	-1.1	-0.9
Standing height	0.1	0.8	2.6	-0.3	-1.6	-0.3	-0.0	0.9	0.4	-1.3	1.1	-1.0	-0.8
Length of working week for main job	0.4	0.5	1.1	0.8	0.7	0.1	1.0	-0.2	0.7	-0.6	0.6	1.0	-0.5
Exposure to tobacco smoke at home	0.5	0.6	1.3	-1.1	-0.2	1.1	0.2	0.2	0.9	0.8	1.1	0.5	-0.4
Breastfed as a baby	0.5	0.6	1.7	-1.3	0.8	-0.1	-0.1	0.8	0.3	-0.3	1.0	-1.3	-0.2
Tense / ‘highly strung’	1.9	3.1	16.5	1.1	-2.3	1.2	1.1	-4.1	0.6	-0.6	-1.7	0.9	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.1	0.9	-1.2	1.8	0.2	-1.7	1.4	0.4	-0.9	0.3	0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	0.6	0.8	-0.8	0.7	-1.5	-1.4	0.4	-1.1	0.4	-0.1
Birth weight of first child	0.7	1.3	3.1	-0.9	-0.5	0.9	-1.0	-1.5	0.8	-0.8	-1.8	-1.4	1.4
Peak expiratory flow (PEF)	1.4	3.3	7.5	-0.8	0.7	1.7	-0.9	2.7	2.1	2.7	2.6	-0.6	-1.3
Pulse wave reflection index	0.9	1.1	3.9	-1.8	-1.3	-0.5	-0.3	-0.2	-0.9	-2.0	0.0	-1.2	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	6.0	-0.2	1.1	0.8	0.0	0.5	0.3	2.4	1.2	0.6	-0.6
Loud music exposure frequency	0.7	0.7	2.3	0.9	-1.2	0.3	0.9	-0.3	0.6	-1.5	0.1	1.2	0.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.8	-1.5	-0.5	1.6	-0.8	-0.4	1.0	-1.1	-1.2	-1.2	2.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	0.4	-0.2	-0.3	-0.2	-0.0	-0.7	0.2	0.1	-0.2	-0.6
Blood clot in the leg (DVT)	1.3	1.6	4.8	-0.9	-0.2	1.3	-0.1	2.0	1.7	1.0	2.2	0.1	-1.2
Medication: Paracetamol	2.2	3.6	8.0	2.6	-0.5	2.2	1.8	-2.8	2.1	0.3	-1.9	2.3	0.1
Headache pain in last month	2.2	3.7	12.0	3.5	-0.0	1.2	1.5	-2.7	0.9	2.0	-1.5	2.7	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.6	-0.3	-0.5	0.9	-0.5	-1.9	-0.0	-0.2	-1.2	-0.3	1.3
Glaucoma (self-reported)	2.9	3.4	7.1	-0.9	-2.4	0.9	-1.9	-2.7	0.0	-2.4	-2.2	-1.4	1.8
Gout (self-reported)	0.2	0.3	0.7	-0.1	-0.5	0.3	-0.2	0.8	0.7	0.7	0.6	-0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.3	1.1	0.0	-0.3	0.8	0.3	-1.1	-0.7	-0.4	1.1	-0.2
Medication: Amlodipine	0.3	0.5	2.5	-0.4	0.1	-0.5	-0.9	1.6	-0.6	0.8	-0.2	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.2	1.2	0.7	-0.7	1.0	-0.7	-1.4	0.5	-0.3	1.5	-0.3
Birth weight	0.1	0.3	1.5	-1.2	0.7	-0.1	-0.4	-0.2	0.3	-0.4	-0.1	-0.8	0.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.9	-1.8	0.4	1.4	0.1	0.6	2.0	-0.1	0.5	-0.3	0.9
High blood pressure (siblings)	0.4	0.6	1.7	-0.2	-0.6	1.0	-0.2	-1.3	0.8	-0.9	-0.5	-0.1	0.9
Forced vital capacity (FVC), Best measure	0.7	2.5	6.2	-2.2	-0.4	0.3	-1.5	2.2	0.6	0.7	2.5	-1.8	-1.3
Body fat percentage	0.1	0.3	1.2	0.2	-0.6	1.1	-0.7	0.5	0.7	0.3	-0.2	0.2	0.5
Leg fat percentage (right)	0.2	0.8	3.8	-0.3	-0.4	1.9	-0.2	-0.0	1.5	-0.2	-0.6	0.4	1.0
Arm fat-free mass (right)	0.3	1.4	4.0	-1.4	0.4	0.6	0.7	2.0	1.6	0.2	1.9	-0.4	-0.8
Exposure to tobacco smoke outside home	1.6	2.2	6.0	1.0	-0.0	2.4	1.6	0.2	2.4	1.5	1.2	1.6	-0.8
Comparative body size at age 10	0.9	2.4	5.5	-1.1	2.4	-1.0	-0.2	2.3	-0.6	1.9	1.9	-0.8	-1.6
Number of full brothers	2.2	2.8	7.3	-1.4	2.2	-0.3	0.3	2.3	0.6	2.7	2.5	-0.7	-1.3
Worry too long after embarrassment	0.4	0.7	3.3	-0.4	0.8	-0.5	-0.7	0.6	-0.6	1.8	-0.0	-1.0	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.5	1.5	-2.1	0.6	0.5	-2.0	0.5	-0.8	-0.5	0.5	0.3
Wheeze or whistling in the chest in last year	1.7	3.0	9.7	3.1	0.1	0.7	2.8	-1.3	0.9	0.6	-0.1	3.0	-0.7
Number of children fathered	0.8	0.9	3.1	-0.2	0.3	1.8	0.7	-0.4	1.2	-0.3	-1.2	0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.6	1.7	-0.5	-0.2	-0.5	-1.2	-0.7	-0.2	-2.4	0.3	1.8
Age at first live birth	0.9	1.6	4.2	-1.6	0.4	-1.4	-1.8	1.4	-1.4	0.0	-0.2	-2.0	-0.1
Pulse wave peak to peak time	1.3	1.6	3.2	1.7	1.4	-1.1	1.4	0.9	0.2	1.8	1.2	0.9	-1.2
Health satisfaction	0.4	0.5	1.4	1.1	0.2	1.2	0.4	-0.7	0.9	0.2	-0.1	0.7	-0.7
Shortness of breath walking on level ground	0.7	0.9	2.1	1.3	-0.7	1.4	0.4	-1.1	0.5	0.5	-1.2	0.8	0.9
Qualifications: College or University degree	0.8	2.4	8.0	-1.8	-0.8	-1.2	-1.8	0.3	-1.0	-2.3	-0.7	-2.8	0.5
Eye problems/disorders: None of the above	0.3	0.3	1.0	-0.7	-0.1	-1.0	0.2	0.2	-0.6	-0.4	0.8	-0.3	-0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.1	-0.6	-0.9	-0.5	0.5	-0.4	-0.0	-0.1	-0.4	-0.6
Emphysema/chronic bronchitis	0.9	1.0	3.6	1.3	0.2	1.1	1.9	-0.8	1.2	-0.0	-0.6	1.1	0.3
Medication for pain relief, constipation, heartburn	2.0	3.3	6.6	-2.6	0.3	-1.6	-2.5	1.9	-2.5	-0.9	0.3	-2.5	1.0
Neck or shoulder pain in last month	1.1	1.6	6.7	0.5	-1.8	1.2	0.0	-2.6	1.2	-1.2	-1.0	-0.2	0.6
Medication: Blood pressure	0.4	0.7	4.1	-1.0	0.8	-0.0	-0.9	2.0	0.3	0.2	0.3	-0.4	-0.1
Angina (self-reported)	1.5	1.9	5.8	-0.4	0.7	-0.3	0.6	2.4	0.6	1.5	2.2	-0.2	-2.2
Migraine (self-reported)	4.7	5.8	16.0	4.0	1.7	1.3	3.4	0.2	1.1	2.8	0.2	4.0	-0.9
Medication: Ibuprofen	2.0	2.4	5.5	2.4	-1.6	1.3	2.0	-1.7	1.7	-0.2	-0.8	1.8	-0.0
Medication: Allopurinol	0.4	0.5	1.6	0.0	-1.1	1.2	-0.2	0.5	1.2	0.3	-0.2	-0.1	-0.4
Medication: Omeprazole	0.2	0.2	1.1	-0.4	-0.1	0.3	-0.4	0.2	0.6	1.1	0.3	-0.2	-0.2
Medication: Seretide 50 evohaler	1.3	1.5	6.9	1.4	2.6	-0.5	1.7	0.5	0.0	0.6	-0.2	1.6	0.2
Mean time to correctly identify matches	1.0	1.9	7.3	0.6	1.5	-2.5	0.8	1.4	-2.7	-0.4	-0.6	0.2	-0.2
Heart disease (mother)	1.4	1.8	4.2	-0.9	-0.1	-0.5	-2.0	-0.8	-1.2	-0.2	-1.8	-1.6	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	5.5	-2.4	1.0	-1.1	-1.4	0.3	-0.6	0.3	0.6	-2.2	0.4
Whole body fat mass	0.1	0.5	1.5	-0.3	-0.5	1.2	-0.5	1.1	1.1	0.3	0.2	-0.1	0.3
Leg fat mass (right)	0.2	0.8	3.4	-0.4	-0.3	1.8	-0.1	1.0	1.6	0.2	0.3	0.3	0.4
Arm predicted mass (right)	0.3	1.4	4.2	-1.2	0.1	0.7	0.6	2.0	1.7	0.1	1.9	-0.5	-0.8
Pulse rate, automated reading	2.7	8.7	45.3	2.5	-1.3	1.2	-0.3	-6.7	0.3	-1.2	-4.4	1.2	3.2
Alcohol intake frequency.	0.9	2.2	6.1	0.2	1.1	0.6	0.4	2.3	0.4	1.4	2.5	1.5	-2.0
Comparative height size at age 10	0.2	1.1	3.0	-1.5	-0.8	0.2	-1.5	0.1	0.1	-0.9	-0.1	-1.7	1.3
Number of full sisters	2.6	3.2	9.5	2.0	1.0	1.4	1.0	1.5	1.2	3.1	1.6	2.2	-1.7
Suffer from ‘nerves’	1.9	3.1	15.1	2.2	-2.3	0.0	0.8	-3.9	-0.9	-0.5	-1.8	0.5	0.4
Overall health rating	0.8	1.8	6.1	2.5	1.0	-0.5	2.1	0.4	-0.0	1.1	0.6	1.7	-1.3
Chest pain or discomfort	0.3	0.4	1.2	-0.7	-1.0	1.1	-0.6	-0.3	0.8	-0.4	0.2	-0.0	-0.1
Had major operations	1.5	1.7	6.5	-2.5	0.6	-1.1	-1.6	0.6	-0.5	-0.4	0.1	-2.2	1.0
Age at last live birth	2.1	3.1	9.6	-3.1	0.6	-1.1	-2.6	2.0	-1.7	-0.5	0.3	-2.4	0.2
Family relationship satisfaction	0.7	0.8	3.5	1.9	0.4	-0.5	0.7	0.7	-0.4	0.7	0.7	0.6	-1.3
Leg pain on walking	0.4	0.6	1.6	0.4	1.3	-0.6	0.6	-0.8	-0.9	1.1	-0.3	0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	5.3	-0.5	2.3	-1.2	-0.7	0.9	-1.1	1.7	1.0	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.9	2.2	0.6	1.2	2.0	-0.7	0.9	1.5	-0.4	2.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-0.8	-1.1	0.9	-0.5	0.2	0.7	-1.1	-0.1	-0.1	0.1
Medication: Aspirin	1.8	2.4	5.3	1.1	2.0	-0.7	2.3	1.5	0.9	1.6	1.6	1.4	-1.7
Supplements: Vitamin C	0.7	0.8	2.3	1.2	0.3	-0.4	0.3	-0.2	-0.3	1.5	-0.2	1.5	-1.3
Knee pain experienced in last month	0.6	1.0	2.5	0.6	0.8	-1.4	0.6	-1.6	-1.4	0.8	-0.9	0.4	-0.1
Hypertension (Self-reported)	0.2	0.5	2.8	0.3	-0.5	0.1	-0.3	1.7	0.2	-0.4	1.1	0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	0.2	-0.5	0.1	-0.0	-0.5	0.1	0.9	0.6	0.9	-0.9
Illnesses of father: Heart disease	1.3	1.8	4.5	-2.1	0.6	-0.9	0.0	1.8	-0.1	-0.0	2.1	-1.4	-1.6
Illnesses of siblings: Diabetes	0.1	0.1	0.5	0.4	0.2	-0.5	0.7	-0.1	0.2	0.2	-0.1	-0.0	-0.0
Smoking status: Previous	0.7	1.1	3.1	-0.4	-0.6	1.7	-0.3	-1.8	1.3	0.5	-0.6	-0.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.2	-0.3	0.4	-1.1	-0.2	1.2	-0.4	1.0	1.8	-0.7	-1.8
Whole body fat-free mass	0.4	2.2	8.2	-1.3	0.8	0.2	0.9	2.9	1.4	0.5	2.5	-0.6	-1.4
Leg fat-free mass (right)	0.6	3.1	12.1	-0.6	1.5	-0.2	0.7	3.5	0.7	1.7	2.8	-0.1	-2.1
Arm fat percentage (left)	0.1	0.4	2.3	0.2	0.2	0.5	-0.5	1.5	0.3	1.0	0.4	0.3	-0.3
Average weekly red wine intake	0.7	1.0	3.0	-0.8	0.5	1.3	-0.3	-1.0	1.7	-0.9	-0.6	-0.6	1.3
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.3	1.3	-0.4	2.0	1.4	1.9	2.3	1.1	1.6	1.8	-1.2
Mood swings	0.4	0.8	2.0	0.9	0.1	1.3	0.5	-1.1	1.0	1.4	0.1	0.8	-0.1
Loneliness, isolation	0.5	0.8	1.7	1.3	-0.7	-0.9	1.3	-1.0	-1.0	-0.3	-0.1	0.8	-0.4
Long-standing illness, disability or infirmity	0.5	0.8	2.1	0.9	-0.9	1.1	0.9	-0.6	1.1	-0.2	0.9	1.4	-0.3
Ever had bowel cancer screening	1.5	1.8	5.2	-1.7	-0.5	-0.1	-2.3	-0.6	-1.3	-0.9	-1.5	-1.4	1.4
Diabetes diagnosed by doctor	0.6	0.9	3.3	1.6	-0.5	0.1	1.8	-0.7	0.2	-0.9	-0.4	1.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.4	0.1	-1.0	0.4	-0.9	-0.2	-0.3	-0.5	-1.5	-0.5	0.4
Friendships satisfaction	0.4	0.5	1.3	1.1	0.2	-0.1	0.0	0.9	-0.2	1.1	0.8	-0.1	-1.0
Qualifications: nursing, teaching	0.6	1.0	3.0	-0.6	0.5	0.4	-1.1	-0.2	0.1	0.2	-1.6	-1.4	1.7
Commuting to job workplace: Walk	2.2	2.4	4.9	-2.0	-0.5	-1.8	-2.2	0.0	-1.7	-2.0	0.3	-2.1	0.0
Eye problems/disorders: Cataract	0.5	0.6	1.3	-0.3	-0.0	0.9	0.7	-0.5	1.1	-1.0	-1.1	-0.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	0.4	-1.4	0.1	-0.5	-1.4	-0.3	-0.7	-0.6	-0.2	0.7
Medication for cholesterol	0.9	1.3	5.8	0.2	0.8	-0.8	-0.4	-1.8	-1.2	-1.0	-2.4	-0.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	0.4	-0.1	0.4	0.5	-0.6	0.9	0.6	-0.6	-0.1	0.4
Back pain experienced in last month	0.5	0.7	2.7	0.6	1.6	0.5	0.8	-0.1	0.5	1.5	-0.1	0.6	-0.3
Mineral and other dietary supplements	0.4	0.6	1.8	0.3	-1.4	-0.3	-0.1	0.4	-0.3	0.9	1.1	0.5	-1.2
Breast cancer (self-reported)	0.8	0.9	6.2	0.8	0.3	-0.2	0.8	-2.5	0.1	-1.0	-0.8	0.0	0.5
Asthma (self-reported)	1.0	1.9	5.8	2.4	0.7	-0.2	2.0	-0.1	-0.2	1.2	0.9	2.0	-1.4
Osteoporosis (self-reported)	0.2	0.3	1.0	0.7	-0.1	0.6	1.0	-0.4	0.8	-0.0	-0.1	0.4	0.2
Osteoarthritis (self-reported)	0.8	1.0	2.7	-0.5	0.5	0.9	0.9	-1.4	0.8	-0.3	-1.6	0.3	1.6
Medication: Aspirin	1.5	2.0	5.0	1.2	1.9	-0.9	2.2	1.1	0.6	1.4	1.2	1.3	-1.4
Medication: Gliclazide	1.2	1.3	3.8	-0.6	-1.3	1.8	-0.5	1.1	2.0	0.4	1.4	0.5	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	1.0	-0.2	-0.1	0.0	0.5	-0.9	0.6	-0.2	0.9	-0.1
Smoking status: Current	0.3	0.5	2.0	0.4	-0.2	-1.3	0.4	0.4	-1.4	-0.2	0.1	0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	10.5	-1.7	-0.0	0.8	-2.0	3.2	1.0	1.8	3.1	-1.3	-1.8
Whole body water mass	0.4	2.2	8.6	-1.1	1.0	0.1	0.9	2.9	1.2	0.7	2.5	-0.6	-1.4
Leg predicted mass (right)	0.6	3.2	12.5	-0.6	1.4	-0.2	0.7	3.5	0.7	1.7	2.9	-0.1	-2.1
Arm fat mass (left)	0.2	0.8	3.6	-0.3	0.1	1.1	-0.1	1.9	1.1	0.9	0.7	0.1	-0.2
Number of self-reported non-cancer illnesses	1.2	2.0	4.2	1.3	0.9	-0.1	1.4	1.6	0.5	1.2	1.9	2.0	-1.8
Average weekly champagne plus white wine intake	0.4	0.6	2.3	-1.5	0.2	-0.1	-0.9	1.3	0.2	-0.6	0.2	-0.8	-0.1
Miserableness	0.8	1.4	4.0	1.5	2.0	-0.3	1.5	-0.6	-0.2	1.6	0.2	1.5	-0.6
Guilty feelings	0.5	0.7	3.1	1.0	0.4	1.0	1.0	-0.2	0.5	1.8	-0.0	0.5	-0.5
Wears glasses or contact lenses	1.0	1.1	3.0	-1.4	0.0	-0.9	-0.6	-1.3	-0.0	-1.7	-0.9	-1.2	1.1
Ever taken oral contraceptive pill	0.3	0.3	1.0	-1.0	0.6	0.2	0.4	0.2	0.7	-0.9	0.0	-0.4	0.1
Hearing aid user	0.4	0.4	1.3	-0.5	-0.3	1.1	-0.5	0.6	1.2	0.1	0.8	-0.1	0.0
Mother’s age at death	1.0	1.3	4.7	-2.2	-1.7	0.6	-0.8	0.8	0.6	-0.9	1.1	-0.6	-0.8
Financial situation satisfaction	1.4	1.8	5.2	2.1	1.4	-0.4	1.6	0.4	-0.2	1.2	0.8	2.3	-0.9
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.4	0.5	1.0	-0.0	0.2	1.7	0.0	1.3	1.9	0.8	-1.6
Commuting to job workplace: Public transport	4.3	5.2	17.6	-1.5	-2.7	-0.4	-1.4	-3.1	-1.3	-4.2	-2.3	-1.6	1.6
Eye problems/disorders: Glaucoma	1.3	1.5	2.8	-0.8	-1.2	-0.3	-1.4	-1.6	-0.3	-1.7	-1.4	-1.4	1.1
Medication: Blood pressure	0.3	0.7	3.4	-0.3	-0.4	0.2	0.3	1.3	0.5	0.3	1.8	-0.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.3	0.6	-0.4	1.1	-0.8	-0.5	0.6	-0.8	0.3	0.2
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.2	-1.3	1.4	0.2	-1.0	-0.9	0.1	-1.1	-1.7	-1.5	2.0
High cholesterol (Self-reported)	0.8	1.5	4.7	0.5	0.2	-0.0	0.6	1.7	0.8	1.0	2.2	0.9	-1.9
Medication: Bendroflumethiazide	0.5	0.7	2.9	-1.1	-1.0	-0.4	-0.2	-1.0	-0.2	-1.7	0.4	-0.4	0.6
Medication: Paracetamol	2.8	4.3	12.2	3.5	-1.0	1.5	2.5	-3.1	2.0	-0.2	-1.6	2.4	-0.4
Medication: Lisinopril	0.6	0.8	1.9	-0.8	-0.6	1.3	-0.7	0.6	1.4	-0.6	-0.2	-1.1	1.0
Medication: Atorvastatin	0.1	0.2	0.7	-0.8	0.3	-0.2	-0.3	0.3	0.2	0.2	0.0	-0.5	-0.4
Illnesses of father: High blood pressure	0.9	1.1	4.0	-2.0	0.4	1.1	-0.7	-0.3	1.5	0.2	-0.4	-1.5	0.8
Alcohol drinker status: Never	0.7	0.8	2.6	0.3	1.6	-0.5	-0.1	1.3	-0.0	0.7	1.1	0.6	-1.2
Ever smoked	0.3	0.4	1.2	-1.1	0.8	0.1	-0.2	0.3	0.7	1.0	0.4	-0.9	0.0
Basal metabolic rate	0.4	2.1	8.5	-1.0	0.8	0.3	0.8	2.9	1.3	0.7	2.4	-0.4	-1.4
Leg fat percentage (left)	0.1	0.5	2.6	-0.1	-0.1	1.6	-0.2	0.1	1.1	0.1	-0.6	0.2	0.8
Arm fat-free mass (left)	0.3	1.6	4.9	-1.5	0.5	0.8	0.6	2.2	1.7	0.2	1.8	-0.7	-0.7
Number of operations (self-reported)	1.3	1.9	3.7	-0.1	1.7	-1.8	0.8	1.9	-1.0	1.7	1.6	-0.1	-1.4
Average weekly beer plus cider intake	0.3	0.4	1.1	0.7	-0.8	0.7	1.1	-0.3	0.6	0.2	0.1	1.0	-0.2
Irritability	0.3	0.6	2.7	-0.4	-1.3	0.1	-1.6	-0.8	-0.5	0.0	0.2	-0.6	-0.2
Risk taking	0.7	1.0	3.4	-0.3	-0.4	1.5	-1.0	-0.7	0.8	-0.6	-1.2	-0.5	1.9
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.2	-0.8	0.4	-0.5	-0.2	0.3	0.0	-0.1	0.3	-1.5	-0.4
Fractured/broken bones in last 5 years	0.8	1.1	4.9	-0.7	1.0	0.1	-0.5	2.2	0.4	1.4	1.4	-0.3	-0.2
Age started oral contraceptive pill	0.4	0.5	2.2	-1.0	-0.4	1.5	-0.3	-0.4	1.0	0.0	-0.1	0.2	0.4
Diastolic blood pressure, automated reading	0.6	1.8	6.5	-2.5	-0.5	1.0	-0.7	1.5	1.3	-1.3	1.2	-1.5	0.2
Ever depressed for a whole week	0.1	0.1	0.4	0.5	-0.3	0.2	0.7	-0.5	0.1	0.1	0.1	0.5	0.1
Unable to work because of sickness or disability	0.7	0.8	2.8	1.1	0.7	-1.0	1.7	0.1	0.3	-0.1	1.1	1.0	-0.9
Commuting to job workplace: Cycle	0.3	0.3	1.6	-0.3	-1.2	0.1	-0.6	0.9	-0.0	0.1	0.5	-0.4	-0.1
Myopia	7.7	11.1	21.6	-3.7	-2.9	1.6	-4.0	-2.8	0.7	-4.2	-3.4	-3.5	4.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.9	-0.4	0.3	-0.3	-0.6	-2.2	-0.8	-0.1	-1.8	-0.8	1.3
Cholesterol lowering medication	0.9	1.3	3.8	-0.0	0.5	0.7	0.8	1.5	1.6	1.2	2.0	0.3	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.7	-0.9	-0.7	1.5	-0.7	-0.2	1.6	1.0	-0.1	0.0	0.5
Pain experienced in last month	0.9	1.4	4.2	-2.0	-0.8	0.2	-1.8	1.9	-0.5	-0.6	1.0	-0.8	-0.5
Supplements: Calcium	0.4	0.5	2.4	0.8	0.7	-0.4	-0.5	-0.3	-0.4	0.7	-1.6	-0.3	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	0.3	-0.6	0.8	1.2	-0.7	0.8	-0.6	0.7	0.9	0.1
Heart attack/myocardial infarction (self-reported)	2.2	2.8	8.1	-0.9	1.9	-0.5	0.6	2.9	-0.2	2.7	2.1	0.0	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.1	-1.5	-0.4	1.5	-0.6	1.9	1.9	0.9	2.0	-0.4	-1.0
Heart disease (siblings)	0.7	0.8	4.0	-0.4	-1.1	-0.4	0.8	0.6	0.3	-0.5	2.0	0.3	-1.0
Alcohol drinker status: Previous	0.5	0.6	2.0	0.9	0.9	0.7	-0.1	0.8	0.7	1.4	0.1	0.6	-0.4
Pack years of smoking	0.4	0.6	2.6	1.1	0.8	0.2	1.6	-0.0	0.6	0.5	-0.1	0.7	-0.2
Impedance of whole body	0.6	3.0	8.4	1.3	-2.9	0.2	-1.5	-2.6	-0.9	-1.3	-2.5	-0.1	1.4
Leg fat mass (left)	0.2	0.6	2.2	-0.5	-0.2	1.5	-0.2	1.3	1.3	0.4	0.4	0.1	0.2
Arm predicted mass (left)	0.3	1.6	5.1	-1.4	0.3	0.7	0.7	2.3	1.7	0.0	1.9	-0.6	-0.9