Hub : Genes

KIAA0195

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1260	0.0400	1.3e-04	0.070	NA	0.091	NA	0.114	1.1e-04	NA	1.0e-05	NA	7.4e-07
2	GTEx	Artery Tibial	0.2545	0.0537	3.0e-12	0.219	NA	0.181	NA	0.205	4.8e-17	NA	3.9e-14	NA	5.6e-16
3	GTEx	Lung	0.0899	0.0392	3.7e-03	0.008	NA	0.032	NA	0.055	6.9e-02	NA	1.6e-03	NA	5.2e-05
4	GTEx	Nerve Tibial	0.1204	0.0520	9.7e-03	0.005	NA	0.027	NA	0.007	1.4e-01	NA	5.2e-03	NA	9.3e-02
5	GTEx	Testis	0.1590	0.0610	1.8e-03	0.112	NA	0.044	NA	0.048	1.2e-05	NA	4.8e-03	NA	3.5e-03
6	GTEx	Thyroid	0.1680	0.0550	4.3e-04	0.071	NA	0.034	NA	0.061	4.1e-06	NA	1.1e-03	NA	2.0e-05
7	YFS	Blood	0.0618	0.0152	5.6e-17	0.047	0.065	0.072	0.069	0.071	4.7e-15	2.1e-20	2.3e-22	1e-21	2.9e-22

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.4	2.2	4.1	1.1	1.4	1.7	2.0	0.6	1.1	-1.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.5	0.3	0.8	-0.3	0.3	0.3	-0.7
Depressed Affect (Nagel 2018)	0.5	1.0	4.6	0.4	0.7	-0.5	-2.1	-0.8	-0.2	0.9
Depression (Nagel 2018)	0.2	0.3	1.2	-0.1	0.1	1.1	-0.8	0.2	0.2	-0.4
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.9	-1.6	-0.6	-0.9	2.0	-1.8	-1.7	1.0
Neuroticism (Nagel 2018)	0.5	1.1	2.9	1.2	1.2	-0.3	-1.7	0.7	1.2	-0.4
Schizophrenia (2018)	0.4	0.8	4.1	-0.2	-0.7	-0.4	-2.0	-0.1	-0.5	0.6
Schizophrenia vs Biploar Disorder	1.7	2.3	8.8	-1.1	-1.1	-1.5	-3.0	-0.7	0.0	1.3
Worry (Nagel 2018)	1.4	3.0	4.1	1.9	2.0	1.1	-1.4	1.8	2.0	-1.7
Alzheimer’s Disease (in mother)	1.9	2.2	4.2	-1.7	-2.0	-0.2	-1.5	-1.5	-1.5	1.4
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.8	0.7	-0.2	0.8	-0.5	-0.4	0.1
Alzheimer’s Disease (including proxy)	1.0	1.4	2.4	-0.8	-1.1	-0.1	-1.5	-1.4	-1.3	1.4
Crohns Disease (2017)	0.1	0.2	0.4	-0.5	-0.6	-0.3	-0.6	-0.1	-0.3	-0.4
Irritable Bowel Disease (IBD)	0.5	1.2	2.2	1.5	0.8	1.0	-0.3	1.1	0.9	-1.5
Ulcerative Colitis (UC)	2.2	4.1	7.8	2.8	2.0	1.8	-0.1	2.0	1.9	-2.5
Major Depression (MDD)	1.5	1.8	4.7	1.5	1.2	1.2	2.2	1.4	0.0	-0.9
Reaction Time	1.0	2.0	4.8	-1.1	-0.9	-0.6	-2.2	-1.4	-1.4	1.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.4	-1.3	-1.0	-0.1	1.5	-1.8	-1.8	1.4
Breast Cancer	0.8	2.0	7.3	-0.3	0.0	-2.0	-0.5	-1.1	-1.0	2.7
Ovarian Cancer	0.7	1.0	2.0	-1.0	-0.5	-1.4	0.5	-1.2	-1.4	0.2
Prostate Cancer	0.9	1.3	1.7	-0.9	-1.2	-1.3	-1.1	-1.1	-1.0	1.3
Age at First Birth	0.1	0.1	0.4	-0.1	0.2	-0.4	0.2	-0.3	0.1	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.0	5.7	0.1	-0.1	-0.1	2.4	0.7	0.6	-0.8
Coronary Artery Disease (CAD)	0.7	0.8	2.7	-0.2	-0.5	0.6	-1.2	0.9	0.0	1.6
Crohns Disease (2012)	0.4	0.6	1.7	-0.9	-0.9	-0.2	-1.3	-0.5	-0.6	0.2
Mean Putamen Volume	0.9	1.1	2.1	0.7	1.1	-1.4	-0.9	1.2	1.1	0.6
Fasting Glucose	1.4	1.6	2.2	-1.5	-1.4	0.7	-1.1	-1.4	-1.4	1.3
HbA1C	0.5	0.6	2.3	-1.0	-0.5	-1.5	-0.1	-0.1	-0.3	0.5
HDL Cholesterol	0.4	0.6	0.9	-0.6	0.1	-0.9	-1.0	-0.9	-0.9	0.9
LDL Cholesterol	0.4	0.6	1.6	1.3	1.1	0.1	0.2	0.1	0.8	-0.8
Lupus	0.5	0.8	2.4	-1.1	-1.2	0.5	-1.5	0.4	-0.3	0.1
Neuroticism (2016)	0.2	0.3	0.7	0.7	0.4	0.3	0.3	0.5	0.8	-0.4
Primary Biliary Cirrhosis	0.7	1.0	4.0	0.2	-0.2	2.0	-1.3	0.5	0.5	-0.6
Rheumatoid Arthritis	0.7	1.0	2.6	-1.1	-1.2	-0.9	0.2	-0.5	-0.4	1.6
Schizophrenia (2014)	0.4	0.9	4.1	-0.4	-1.0	0.6	-2.0	-0.4	0.0	0.4
Triglycerides	0.5	0.9	1.9	0.8	0.5	1.2	0.8	0.6	0.9	-1.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.2	0.6	1.0	-1.1	0.2	0.3	0.2	-0.2
Ulcerative Colitis	1.1	1.6	3.8	2.0	1.3	0.9	-1.5	1.4	0.0	-0.8
Blood Eosinophil Count	0.1	0.8	2.4	1.5	0.6	-0.4	-0.0	1.0	0.7	-1.2
Blood Platelet Count	0.3	3.1	12.1	0.3	0.7	-1.1	3.5	0.1	0.0	-2.8
Blood Red Count	1.0	9.3	17.5	4.0	3.4	2.1	0.5	2.6	3.0	-4.2
Blood White Count	0.7	5.1	13.0	2.4	1.8	1.8	1.1	2.3	2.1	-3.6
Heel T-Score	0.4	3.2	9.5	2.5	3.1	1.6	1.7	0.4	0.9	-0.7
BMI	0.2	1.3	4.0	-1.4	-2.0	0.1	-1.0	-0.5	-0.6	1.0
Height	0.4	8.2	20.0	2.5	2.1	1.3	2.2	3.8	2.3	-4.5
Waist Hip Ratio (WHR)	1.6	7.1	18.7	1.9	1.5	3.0	-0.4	3.1	2.6	-4.3
Systolic Blood Pressure	0.3	1.5	3.3	1.2	1.8	1.0	1.8	-0.0	0.2	-1.2
Smoking Status	0.9	2.2	4.9	-1.1	-0.9	-2.1	-0.1	-1.5	-1.3	2.2
Allergy or Eczema	3.9	10.2	15.4	-3.4	-3.6	-2.9	-1.6	-3.2	-3.2	3.9
Cardiovascular Disease	0.5	1.5	4.0	0.8	0.6	1.4	0.7	1.4	1.0	-2.0
Hypothyroidism (self reported)	0.1	0.3	1.5	-0.1	-0.6	-0.3	-1.2	0.2	0.1	0.1
Respiratory disease	0.9	2.1	5.2	-1.9	-2.3	-0.5	-0.3	-1.4	-1.7	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.4	-0.6	0.3	-0.4	0.5	-0.2	0.6
Lung FEV1/FVC ratio	0.3	1.7	5.5	-1.3	-2.4	0.3	-0.6	-0.1	0.2	2.0
Lung FVC	1.7	8.8	29.7	-1.6	-1.2	-3.6	-1.9	-2.8	-1.9	5.5
Neuroticism	0.3	0.8	3.7	0.8	1.1	-0.2	-1.9	-0.1	0.1	0.4
Chronotype (morning person)	1.9	4.3	7.6	1.9	2.2	2.3	1.5	2.8	2.0	-1.7
Hair Pigment	0.3	8.6	14.3	2.5	2.0	3.1	1.8	3.7	3.0	-3.8
Tanning	1.2	14.4	22.5	-2.6	-1.9	-4.7	-4.0	-4.3	-3.8	4.3
Hand grip strength (left)	0.5	1.2	3.2	-1.5	-1.8	-1.2	0.6	-0.3	-0.9	0.1
Number of treatments/medications taken	0.3	0.5	1.3	0.2	-0.0	-0.3	-0.8	1.2	1.1	-0.4
Average weekly spirits intake	0.5	0.7	3.5	-0.6	0.2	-0.5	1.9	-0.5	-0.4	-0.0
Sensitivity / hurt feelings	0.1	0.1	0.2	0.3	-0.1	-0.2	-0.1	0.4	0.5	0.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.7	-1.4	-0.7	-1.1	-2.2	-1.2	-1.4	0.8
Hearing difficulty/problems: Yes	0.3	0.5	1.7	0.7	0.5	0.7	0.6	-0.1	0.3	-1.3
Relative age of first facial hair	0.2	0.4	1.6	0.4	0.0	1.2	0.8	0.5	0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.0	-1.4	-1.1	-0.7	-1.2	-0.7	-1.0	0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.7	0.2	0.5	-1.6	-1.1	-0.0	-0.2	1.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	0.5	0.9	-1.1	-0.4	-0.0	0.1	1.0
Systolic blood pressure, automated reading	0.5	1.4	3.2	1.5	1.8	0.8	1.1	0.5	0.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.0	-1.4	-1.1	0.5	-0.3	-0.5	-0.8	1.0
Angina	0.2	0.3	0.5	0.7	0.4	-0.5	0.3	0.7	0.6	0.2
Medication for hormone replacement therapy	0.1	0.1	0.3	0.2	0.2	0.2	0.5	0.4	-0.1	-0.2
Vitamin and mineral supplements	3.5	4.7	7.8	-2.6	-2.7	-2.1	-0.2	-2.5	-2.8	0.5
Supplements: Zinc	0.2	0.2	0.6	0.3	0.4	0.8	-0.8	-0.0	0.2	-0.1
Medication: Co-codamol	0.3	0.3	1.0	0.6	1.0	0.5	0.2	0.5	0.5	-0.3
Medication: Metformin	0.6	0.8	1.6	-1.3	-1.1	-0.3	-0.1	-0.9	-1.0	1.1
Diabetes (father)	0.6	0.8	3.3	-0.8	-0.3	0.8	-1.8	-0.5	-0.8	-0.3
Diabetes (mother)	1.3	1.7	7.3	0.5	-0.0	2.7	-0.4	1.1	1.1	-1.4
Severe depression (siblings)	1.8	2.0	4.0	-2.0	-1.9	-0.5	-0.1	-1.4	-1.4	1.4
Pack years adult smoking proportion	0.7	1.1	2.4	0.8	0.6	1.6	-1.3	1.2	0.9	-0.6
Impedance of leg (right)	1.5	7.3	11.5	3.0	3.4	1.3	2.3	2.5	2.6	-3.3
Leg fat-free mass (left)	0.1	0.3	0.8	-0.3	-0.8	-0.1	-0.1	0.9	0.3	-0.9
Trunk fat percentage	0.1	0.4	2.3	0.1	0.1	-0.1	0.5	0.5	0.4	-1.5
Hand grip strength (right)	0.4	1.0	2.2	-1.4	-1.5	-0.7	1.1	-0.5	-0.9	0.2
Townsend deprivation index at recruitment	0.3	0.5	1.3	0.7	1.1	0.6	-0.4	-0.2	-0.0	1.0
Current tobacco smoking	0.3	0.5	1.2	-0.7	-1.1	-0.7	-0.2	-0.6	-0.7	0.8
Average weekly fortified wine intake	0.6	0.7	3.5	-0.5	-0.0	-0.9	1.9	-0.2	0.0	-0.4
Maternal smoking around birth	1.6	2.4	4.0	-1.5	-1.4	-2.0	-2.0	-1.5	-1.1	1.0
Fed-up feelings	0.7	1.2	2.6	-0.8	-0.5	-0.9	-1.1	-1.4	-1.0	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	-1.3	-0.8	-0.0	-1.1	-0.7	-1.0	0.3
Relative age voice broke	0.2	0.3	1.0	0.3	-0.2	1.0	0.8	-0.1	0.1	0.7
Taking other prescription medications	0.8	1.2	3.8	-1.3	-1.9	-0.8	-1.2	0.2	0.1	1.0
Age when periods started (menarche)	1.9	4.7	8.7	-2.0	-1.3	-2.3	-0.3	-2.9	-2.8	2.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	-0.8	-0.2	-1.0	-0.9	-0.9	-0.8	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.7	1.2	1.5	-0.5	1.9	0.5	0.5	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	-0.4	-1.0	-0.8	-0.2	0.2	0.0	-0.2
Qualifications: CSEs or equivalent	0.7	0.9	3.0	0.9	-0.1	0.0	-1.0	1.0	0.7	-1.7
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-0.3	-0.7	0.8	-1.0	0.7	0.4	-1.0
High blood pressure	0.5	1.4	5.2	0.6	0.5	1.1	0.4	1.4	1.1	-2.3
Hayfever, allergic rhinitis or eczema	3.3	7.2	11.2	-3.2	-3.2	-2.0	0.2	-2.8	-2.7	3.4
Multivitamins +/- minerals	1.0	1.2	2.3	1.5	1.5	1.3	0.1	1.1	1.2	0.0
Stomach or abdominal pain in last month	1.2	1.6	3.1	0.6	0.2	1.8	0.7	1.7	1.7	-1.1
Supplements: Glucosamine	1.0	1.3	3.3	1.1	1.2	1.8	-0.6	1.2	1.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	-0.6	-0.1	0.5	0.9	-0.7	-0.4	0.0
Medication: Atenolol	1.9	2.4	3.7	1.9	1.9	0.9	0.8	1.5	1.7	-1.7
Medication: Levothyroxine sodium	0.0	0.1	0.2	-0.1	-0.3	-0.1	-0.4	0.2	0.1	-0.0
Sitting height	0.0	0.1	0.4	-0.0	0.2	-0.2	-0.5	-0.2	-0.6	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	0.3	0.2	1.4	-1.2	0.2	0.5	-0.5
High blood pressure (mother)	0.7	1.0	2.7	1.1	1.6	0.4	0.5	1.0	0.9	-0.8
Body mass index (BMI)	0.4	1.7	4.1	-1.8	-2.0	-1.0	-0.9	-1.0	-1.1	0.8
Impedance of leg (left)	1.1	5.3	9.0	2.6	3.0	1.5	2.3	1.9	1.9	-2.6
Leg predicted mass (left)	0.1	0.4	1.0	-0.2	-0.7	-0.0	0.1	1.0	0.4	-0.9
Trunk fat mass	0.1	0.6	2.9	0.1	-0.2	0.2	0.4	0.8	0.5	-1.7
Waist circumference	0.2	0.8	3.2	-0.2	-0.6	0.5	-0.3	1.1	0.6	-1.8
Number of incorrect matches in round	0.4	0.7	1.9	1.1	1.4	0.2	-0.8	0.4	0.6	-0.8
Past tobacco smoking	1.2	2.3	4.3	0.9	0.6	1.8	2.1	1.6	1.5	-1.5
Alcohol usually taken with meals	2.1	3.3	6.5	-2.1	-1.9	-0.5	-2.5	-1.8	-1.8	1.5
Nervous feelings	0.6	1.1	6.3	0.2	0.4	-0.4	-2.5	0.7	0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.2	-1.3	-0.6	-0.1	-1.5	-1.0	-1.5	1.3
Hearing difficulty/problems with background noise	0.7	1.1	2.6	0.9	1.6	1.0	-0.7	0.4	0.5	-1.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	0.1	-0.2	1.2	-1.0	0.3	0.4	-0.8
Had menopause	0.4	0.6	2.9	-0.1	0.1	-0.7	-1.7	-0.4	-0.3	0.3
Had other major operations	0.3	0.4	0.6	0.6	0.7	0.0	0.7	0.8	0.6	-0.4
Forced vital capacity (FVC)	0.2	0.7	3.2	-0.2	-0.2	-1.3	-0.2	-0.1	-0.2	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.5	1.6	1.9	0.9	1.5	1.2	1.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.2	-0.2	-0.1	0.8	1.1	0.3	0.1	0.2
Qualifications: None of the above	0.3	0.7	2.5	0.6	1.6	1.0	-0.3	0.4	0.4	-0.9
Financial difficulties in last 2 years	1.2	1.6	3.0	-1.7	-1.2	-1.4	0.2	-1.5	-1.6	0.0
Mouth/teeth dental problems	1.8	2.7	4.2	2.0	1.4	0.8	2.0	2.0	1.9	-1.0
Heart attack	0.1	0.1	0.7	-0.0	-0.1	-0.8	0.5	-0.1	-0.1	0.1
Allergy	1.8	4.2	8.4	2.7	2.9	1.1	0.2	1.8	2.0	-2.2
Pain all over the body in last month	2.7	2.9	6.0	-1.4	-1.0	-1.9	-1.9	-1.2	-1.5	2.5
Diabetes (self-reported)	1.0	1.5	3.3	-1.6	-1.8	-1.0	-0.5	-0.5	-1.0	1.4
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	3.7	-1.8	-1.7	-1.1	-0.4	-1.9	-1.9	1.8
Medication: Ramipril	0.9	1.2	1.8	-1.1	-0.9	-1.3	-0.4	-1.3	-1.1	1.1
Medication: Simvastatin	0.6	0.9	3.1	0.5	-0.2	-1.8	-1.1	0.7	0.3	-0.9
Fluid intelligence score	0.6	1.2	2.3	-1.4	-0.8	-0.2	0.5	-1.5	-1.5	1.1
Illnesses of siblings	1.2	1.7	2.8	1.7	1.5	-0.1	1.5	1.1	1.2	-1.5
Neuroticism score	0.2	0.5	2.5	0.4	0.6	-0.5	-1.6	-0.1	0.1	0.1
Weight	0.1	0.4	1.2	-0.3	-0.8	0.0	0.1	0.8	0.1	-1.1
Impedance of arm (right)	0.7	3.3	5.9	2.2	2.4	-0.0	1.3	1.4	1.8	-2.4
Arm fat percentage (right)	0.1	0.2	0.5	-0.3	-0.7	-0.6	-0.4	0.1	0.2	-0.5
Trunk fat-free mass	0.2	1.0	3.3	0.5	-0.1	0.7	0.4	1.8	0.9	-1.3
Hip circumference	0.1	0.5	2.0	-0.7	-0.9	-1.4	0.7	0.1	-0.2	0.1
Time employed in main current job	0.6	0.7	2.1	1.2	1.4	0.3	0.5	0.4	0.5	-1.0
Alcohol intake versus 10 years previously	0.6	0.8	4.4	0.5	0.1	0.5	-2.1	0.4	0.1	-0.9
Father’s age at death	2.2	3.0	4.7	-1.6	-1.6	-1.4	-1.4	-2.0	-1.7	2.2
Worrier / anxious feelings	0.9	1.8	4.4	1.2	1.0	0.5	-2.1	1.6	1.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.5	-0.4	0.4	-0.9	0.7	0.4	0.5
Falls in the last year	1.5	2.1	4.2	-1.9	-2.0	-1.2	-1.9	-0.6	-0.9	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.2	-0.5	-0.4	0.6	-0.4	-0.2	0.9
Number of live births	0.7	0.9	4.3	-0.5	-1.1	0.3	2.1	0.2	0.1	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	4.7	-0.5	-0.7	-1.6	-0.4	-0.2	-0.2	2.2
Pulse rate	3.6	6.1	11.4	-3.4	-3.2	-0.2	-2.5	-1.4	-2.2	2.8
Happiness	0.5	0.6	1.0	-0.6	-1.0	0.1	-0.4	-1.0	-0.8	0.9
Noisy workplace	1.3	1.6	3.2	-1.5	-1.7	-0.8	-1.3	-0.3	-0.8	1.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.0	-0.4	-0.5	0.3	0.3	-1.4	-1.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.9	-1.5	-2.2	-0.6	-0.7	-1.1	-1.2	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	1.0	0.2	0.5	0.5	0.2	0.1	0.1	-1.0
Asthma	0.6	1.3	4.9	-1.9	-2.2	0.2	-0.1	-0.2	-0.7	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.8	0.1	0.3	0.9	-0.4	0.3	0.6	0.3
Medication: Cholesterol lowering	0.7	1.0	3.5	-1.0	-1.3	-1.9	-0.0	-0.5	-0.9	0.1
Depression (self-reported)	1.8	2.2	4.9	-1.1	-0.9	-1.3	-1.4	-1.5	-1.4	2.2
Medication: Lansoprazole	0.2	0.2	0.5	-0.4	-0.6	-0.1	-0.2	0.7	0.2	0.7
Prospective memory result	0.9	1.1	1.7	1.2	1.2	0.7	0.8	1.3	1.3	-0.4
Lung cancer (father)	1.5	1.7	3.4	1.7	1.5	0.5	-0.1	1.9	1.6	-0.7
Illnesses of mother	2.1	2.5	4.3	1.5	1.0	-0.1	2.0	2.1	1.9	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	6.5	-0.7	-0.7	-2.1	-0.1	-0.5	-0.6	2.5
Pulse wave Arterial Stiffness index	1.0	1.2	4.9	0.2	-0.3	0.1	0.5	1.5	1.0	-2.2
Impedance of arm (left)	0.7	3.3	7.6	2.2	2.8	-0.2	1.9	1.1	1.4	-1.9
Arm fat mass (right)	0.1	0.3	0.7	-0.5	-0.9	-0.5	-0.3	0.3	0.1	-0.7
Trunk predicted mass	0.2	1.1	3.7	0.6	-0.0	0.7	0.5	1.9	1.0	-1.4
Standing height	1.1	10.6	18.6	3.3	2.7	2.3	2.5	4.1	3.0	-4.3
Length of working week for main job	1.6	1.7	2.4	-1.5	-1.4	-0.9	-1.1	-1.5	-1.6	1.3
Exposure to tobacco smoke at home	0.3	0.4	0.8	0.2	0.5	0.8	0.9	0.6	0.6	-0.3
Breastfed as a baby	0.2	0.2	1.3	0.2	0.4	-0.2	1.1	0.2	0.0	-0.4
Tense / ‘highly strung’	0.3	0.4	2.0	-0.1	0.3	-1.4	0.1	-0.4	-0.1	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	-1.0	-1.3	0.1	0.1	-0.4	-0.4	0.7
Hair/balding pattern: Pattern 4	4.4	10.6	19.0	3.7	4.4	2.8	2.0	3.7	3.2	-2.5
Birth weight of first child	1.2	2.1	9.5	0.6	0.5	3.1	0.2	1.1	1.0	-1.6
Peak expiratory flow (PEF)	0.3	0.7	2.4	-1.0	-0.8	-0.6	-0.1	-0.3	-0.6	1.6
Pulse wave reflection index	4.2	5.2	10.4	2.4	2.3	0.8	2.1	2.2	2.3	-3.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.6	0.0	-0.1	-0.3	-0.2	0.6	0.4	0.7
Loud music exposure frequency	2.6	2.8	5.2	-1.6	-1.1	-1.1	-1.4	-1.8	-2.1	2.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.2	-0.8	-1.5	-0.6	0.5	-1.8	-1.4	1.4
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	5.6	-2.4	-2.1	-1.0	-1.9	-1.9	-2.3	2.1
Blood clot in the leg (DVT)	0.3	0.3	1.5	0.3	0.4	-0.2	-1.2	0.7	0.3	0.1
Medication: Paracetamol	2.1	3.5	8.5	2.4	2.9	1.7	0.1	1.5	1.9	-1.2
Headache pain in last month	0.2	0.3	0.5	-0.7	-0.3	-0.2	-0.7	-0.5	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-0.3	0.2	0.9	-0.9	-0.8	-0.4	0.9
Glaucoma (self-reported)	0.2	0.3	0.7	0.2	-0.2	0.2	0.9	0.6	0.6	-0.7
Gout (self-reported)	0.6	0.8	2.1	0.7	0.8	0.5	0.4	0.9	1.2	-1.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	-0.3	-0.6	-0.3	-0.6	0.2	0.2	0.2
Medication: Amlodipine	0.1	0.1	0.3	-0.3	-0.3	-0.5	-0.5	-0.1	-0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.5	-0.5	-0.6	0.4	0.3	0.2	-0.2
Birth weight	0.2	0.5	1.9	0.8	0.3	0.2	-0.5	0.5	0.6	-1.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.5	-1.0	-0.9	-0.9	-0.8	-1.2	-1.1	0.9
High blood pressure (siblings)	0.4	0.6	2.2	-0.2	-0.2	1.5	-1.3	-0.2	-0.2	-0.0
Forced vital capacity (FVC), Best measure	0.4	1.3	4.5	-0.4	-0.3	-1.9	-0.1	-0.4	-0.6	2.1
Body fat percentage	0.1	0.2	1.2	0.0	-0.1	-0.0	0.3	0.4	0.4	-1.1
Leg fat percentage (right)	0.1	0.3	1.4	-0.0	-0.3	-0.0	0.5	0.6	0.5	-1.2
Arm fat-free mass (right)	0.1	0.7	1.8	0.0	-0.4	0.9	0.5	1.3	0.5	-1.3
Exposure to tobacco smoke outside home	2.3	3.0	5.2	-2.3	-1.4	-0.2	-1.5	-2.2	-2.0	1.7
Comparative body size at age 10	0.5	1.3	2.9	-1.1	-1.6	-0.7	-1.7	-1.0	-1.0	0.4
Number of full brothers	0.5	0.7	4.1	-0.6	-0.4	0.3	2.0	-0.1	-0.1	0.1
Worry too long after embarrassment	0.6	1.1	3.4	0.4	0.3	-1.0	-1.8	1.1	1.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	-1.0	-0.6	0.5	0.6	-0.8	-1.0	1.2
Wheeze or whistling in the chest in last year	1.4	2.5	5.8	-2.2	-2.4	-1.6	-1.0	-0.9	-1.2	0.9
Number of children fathered	0.3	0.4	1.8	0.2	0.4	-1.3	0.2	0.7	0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.4	1.8	1.7	0.3	0.7	1.3	1.3	-1.7
Age at first live birth	0.1	0.1	0.3	0.4	0.6	0.1	0.5	0.2	0.3	-0.3
Pulse wave peak to peak time	0.9	1.1	4.2	-0.1	0.4	-0.2	-0.5	-1.4	-1.0	2.0
Health satisfaction	1.9	2.4	5.8	1.2	0.7	0.2	1.0	2.4	2.0	-2.0
Shortness of breath walking on level ground	0.7	0.8	1.9	-0.1	-0.7	-0.6	-0.5	1.2	1.0	-1.4
Qualifications: College or University degree	1.6	5.0	8.6	2.8	2.6	2.9	1.6	1.7	2.2	-0.9
Eye problems/disorders: None of the above	1.4	1.6	2.9	-1.1	-0.4	-1.2	-1.3	-1.7	-1.5	1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.8	-0.9	-0.9	-0.6	-1.1	-1.4	-1.3	0.9
Emphysema/chronic bronchitis	0.7	0.8	1.5	0.4	0.1	1.2	-1.2	1.1	1.1	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	4.7	0.3	0.2	-0.6	2.2	-0.1	-0.1	-0.4
Neck or shoulder pain in last month	0.4	0.6	1.9	-0.8	-0.9	-0.1	-1.4	0.1	0.0	-0.9
Medication: Blood pressure	0.5	0.8	1.8	1.0	0.4	-0.2	0.2	1.2	1.0	-1.4
Angina (self-reported)	0.2	0.3	0.5	0.6	0.4	-0.6	0.4	0.7	0.5	0.1
Migraine (self-reported)	1.1	1.4	3.7	1.0	0.9	-1.1	1.9	1.2	1.1	-0.7
Medication: Ibuprofen	0.2	0.3	1.0	0.1	0.4	1.0	0.4	0.2	0.5	0.2
Medication: Allopurinol	1.0	1.3	2.4	1.0	0.8	1.2	0.6	1.2	1.6	-1.4
Medication: Omeprazole	1.6	1.9	3.4	1.5	0.8	1.8	-0.1	1.6	1.6	-1.3
Medication: Seretide 50 evohaler	0.9	1.1	2.4	-1.3	-1.0	0.3	-1.6	-1.0	-1.1	0.2
Mean time to correctly identify matches	0.4	0.7	3.2	-0.5	-0.4	0.4	-1.8	-0.6	-0.5	0.7
Heart disease (mother)	0.4	0.5	1.1	-1.1	-0.3	0.6	0.0	-0.9	-0.9	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	-0.8	-0.1	-0.4	1.0	-0.3	-0.5	-0.6
Whole body fat mass	0.1	0.5	2.3	0.1	-0.2	0.1	0.2	0.9	0.6	-1.5
Leg fat mass (right)	0.1	0.4	1.7	-0.1	-0.5	0.1	0.1	0.8	0.5	-1.3
Arm predicted mass (right)	0.1	0.5	1.5	-0.2	-0.6	0.6	0.4	1.2	0.4	-1.0
Pulse rate, automated reading	1.3	4.1	8.9	-2.6	-3.0	1.0	-1.9	-0.9	-1.2	2.4
Alcohol intake frequency.	0.7	1.6	3.3	1.1	0.8	0.6	0.9	1.8	1.2	-1.8
Comparative height size at age 10	1.3	7.0	14.9	2.4	1.5	1.8	0.2	3.8	3.0	-3.9
Number of full sisters	1.6	2.0	4.0	2.0	1.8	0.2	1.3	1.4	1.3	-1.1
Suffer from ‘nerves’	0.3	0.5	2.6	-0.1	-0.2	-0.4	-1.6	0.3	0.3	-0.7
Overall health rating	0.2	0.5	1.0	-0.5	-1.0	-0.3	-1.0	0.8	0.4	-0.6
Chest pain or discomfort	0.1	0.2	0.4	0.0	-0.1	-0.5	0.4	0.7	0.6	-0.3
Had major operations	0.2	0.2	0.5	-0.6	-0.7	0.7	-0.3	-0.1	0.2	-0.3
Age at last live birth	0.3	0.4	1.7	-0.0	0.2	-0.1	1.0	0.1	0.2	-1.3
Family relationship satisfaction	1.6	2.0	3.4	-1.8	-1.4	-0.5	0.5	-1.8	-1.8	1.3
Leg pain on walking	0.8	1.0	2.6	-0.0	-0.8	1.6	-0.7	1.4	1.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.5	6.5	-1.6	-1.9	-2.5	-1.1	-0.9	-1.3	0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	0.4	0.0	0.6	-0.6	0.7	0.6	-1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.9	0.6	1.0	-0.0	1.3	0.1	0.3	1.7
Medication: Aspirin	1.1	1.5	3.7	-1.3	-1.7	-1.9	-0.1	-0.8	-0.9	0.7
Supplements: Vitamin C	1.6	1.9	3.3	1.3	1.6	0.9	-1.0	1.8	1.8	-0.7
Knee pain experienced in last month	0.8	1.2	2.6	-1.0	-1.5	1.6	-1.5	0.2	-0.1	0.3
Hypertension (Self-reported)	0.7	1.9	5.3	0.9	0.9	1.4	0.8	1.5	1.4	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	0.4	0.4	0.8	-1.3	0.7	1.1	0.9
Illnesses of father: Heart disease	0.8	1.1	3.0	-1.7	-1.6	-0.0	-1.1	-0.3	-0.7	0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.8	-0.4	-0.7	1.4	-0.0	0.3	-0.0	-0.2
Smoking status: Previous	0.4	0.6	1.7	-0.2	0.1	-0.9	-1.3	-0.6	-0.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.0	1.7	1.6	0.1	1.0	1.4	1.2	-1.1
Whole body fat-free mass	0.1	0.6	2.0	0.2	-0.4	0.4	0.4	1.4	0.6	-1.1
Leg fat-free mass (right)	0.0	0.3	1.1	-0.5	-1.0	-0.1	0.0	0.6	-0.1	-0.4
Arm fat percentage (left)	0.0	0.2	0.5	-0.4	-0.7	-0.7	-0.1	-0.1	-0.0	-0.2
Average weekly red wine intake	0.2	0.3	0.9	-0.4	-0.4	0.9	-0.5	0.0	0.6	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.6	-0.0	-0.2	-0.8	-0.1	-0.7	-0.3	-0.1
Mood swings	0.5	1.0	4.7	-0.3	0.2	-0.3	-2.2	-0.9	-0.8	0.5
Loneliness, isolation	0.7	1.0	2.8	-0.6	0.1	-0.9	-0.6	-1.6	-1.7	0.2
Long-standing illness, disability or infirmity	1.6	2.4	8.1	-2.3	-2.9	-0.7	-1.1	-0.5	-1.0	0.6
Ever had bowel cancer screening	1.3	1.5	2.6	1.6	1.6	0.6	-0.7	1.1	1.2	-1.4
Diabetes diagnosed by doctor	0.3	0.5	1.4	-1.0	-1.2	-0.3	0.1	-0.1	-0.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	-1.5	-1.4	-1.4	-0.5	-1.3	-1.4	0.1
Friendships satisfaction	0.2	0.3	0.7	-0.2	-0.6	0.3	-0.0	-0.6	-0.6	0.8
Qualifications: nursing, teaching	0.1	0.2	0.8	0.0	-0.2	0.1	0.9	-0.7	-0.3	0.3
Commuting to job workplace: Walk	1.7	1.9	2.4	-1.4	-1.6	-1.3	-0.9	-1.4	-1.4	1.5
Eye problems/disorders: Cataract	0.5	0.6	1.3	1.0	0.2	-0.0	0.3	1.1	1.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.4	-0.6	-0.6	0.2	-0.6	-0.6	-0.1	0.5
Medication for cholesterol	0.3	0.5	1.3	-0.7	-1.0	1.1	0.0	-0.4	-0.1	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	6.4	0.2	-0.2	-0.6	-2.5	0.8	0.4	0.1
Back pain experienced in last month	0.3	0.4	0.8	-0.8	-0.5	0.9	-0.4	-0.5	-0.7	0.5
Mineral and other dietary supplements	0.7	0.9	2.5	-1.3	-1.6	-1.0	0.3	-0.4	-0.6	-0.5
Breast cancer (self-reported)	0.4	0.5	1.5	0.6	1.0	-0.4	0.8	0.0	-0.0	-1.2
Asthma (self-reported)	0.9	1.8	6.8	-2.2	-2.6	-0.1	-0.2	-0.6	-1.0	0.1
Osteoporosis (self-reported)	0.5	0.6	1.2	0.8	0.8	0.3	1.0	0.8	1.1	-0.2
Osteoarthritis (self-reported)	1.6	2.1	4.8	1.5	1.2	1.3	0.3	2.2	1.8	-0.9
Medication: Aspirin	0.7	1.0	3.0	-1.0	-1.4	-1.7	0.2	-0.4	-0.5	0.4
Medication: Gliclazide	0.4	0.4	1.2	-0.6	-1.1	0.2	-0.6	0.8	0.6	-0.2
Illnesses of father: None of the above (group 1)	1.2	1.4	2.6	1.1	1.0	-0.5	1.6	1.2	1.6	-1.0
Smoking status: Current	0.4	0.6	0.9	-0.7	-0.9	-0.9	-0.4	-0.8	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	8.9	-0.9	-0.8	-1.3	-0.2	-0.9	-0.5	3.0
Whole body water mass	0.1	0.6	2.0	0.2	-0.4	0.4	0.3	1.4	0.6	-1.1
Leg predicted mass (right)	0.1	0.3	1.2	-0.6	-1.1	-0.2	0.0	0.5	-0.2	-0.4
Arm fat mass (left)	0.1	0.2	0.6	-0.4	-0.8	-0.5	-0.2	0.3	0.1	-0.7
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-1.0	-1.2	-0.4	-0.6	0.1	-0.3	0.5
Average weekly champagne plus white wine intake	0.2	0.3	1.2	-0.2	0.1	0.3	0.3	-1.1	-0.9	0.2
Miserableness	1.9	3.3	8.0	-1.7	-1.8	-1.4	-2.8	-1.5	-1.4	1.8
Guilty feelings	0.1	0.2	0.4	0.4	-0.4	-0.0	-0.5	0.6	0.6	0.0
Wears glasses or contact lenses	0.1	0.1	0.4	0.2	-0.4	-0.2	-0.7	0.2	0.0	-0.1
Ever taken oral contraceptive pill	2.8	3.1	5.3	-1.9	-2.3	-1.5	-1.4	-1.6	-1.9	1.5
Hearing aid user	0.4	0.5	1.1	-0.8	-0.6	0.1	-0.4	-0.8	-1.0	0.7
Mother’s age at death	0.5	0.7	3.0	0.0	0.1	-1.7	-0.6	-0.7	-0.4	0.8
Financial situation satisfaction	1.0	1.2	2.7	-1.4	-1.1	-0.0	-0.0	-1.6	-1.5	0.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.7	1.0	0.7	0.3	0.2	0.9	1.3	-1.6
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.0	0.4	-0.4	0.6	-0.8	-0.3	-0.7
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	0.6	0.1	0.2	1.2	0.7	0.8	-0.5
Medication: Blood pressure	0.7	1.4	2.6	1.1	1.6	0.2	1.0	1.4	1.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-0.6	-0.7	0.5	-0.9	0.8	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.5	0.1	0.3	0.8	-0.7	-0.7	-0.7	1.9
High cholesterol (Self-reported)	0.4	0.7	2.8	0.8	0.3	-0.2	-1.1	0.6	0.3	-1.7
Medication: Bendroflumethiazide	2.6	3.9	6.3	2.3	2.5	0.9	1.2	2.0	1.9	-2.4
Medication: Paracetamol	1.4	2.1	5.1	1.6	2.2	1.8	0.3	1.1	1.3	-1.0
Medication: Lisinopril	0.2	0.2	0.7	0.1	-0.1	-0.5	0.7	0.8	0.1	-0.4
Medication: Atorvastatin	0.4	0.4	0.7	-0.8	-0.8	0.7	0.6	-0.2	-0.4	0.7
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.2	-0.0	0.8	0.2	-0.5	-0.6	0.7
Alcohol drinker status: Never	0.5	0.6	2.2	-1.2	-1.5	-0.5	-0.7	0.3	0.0	-0.1
Ever smoked	1.0	1.8	2.7	-1.0	-0.7	-1.3	-1.5	-1.7	-1.6	1.3
Basal metabolic rate	0.1	0.5	1.7	0.1	-0.5	0.3	0.3	1.3	0.5	-1.2
Leg fat percentage (left)	0.0	0.2	0.5	-0.4	-0.6	0.1	0.3	0.1	-0.0	-0.7
Arm fat-free mass (left)	0.1	0.8	2.1	0.2	-0.4	0.7	0.3	1.4	0.7	-1.4
Number of operations (self-reported)	0.2	0.3	0.6	0.1	0.2	0.6	0.5	0.8	0.6	-0.5
Average weekly beer plus cider intake	1.3	1.9	3.5	1.5	1.0	1.9	-0.2	1.5	1.5	-1.3
Irritability	0.1	0.2	0.7	-0.4	-0.1	0.8	-0.4	-0.5	-0.1	-0.6
Risk taking	0.3	0.5	1.0	-0.8	-0.8	0.1	-0.1	-0.6	-0.8	1.0
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.0	-0.2	0.4	-0.3	0.3	-2.0	-1.3	1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	0.1	0.3	-0.1	0.1	-0.2	-0.6
Age started oral contraceptive pill	0.3	0.4	1.4	0.2	1.0	0.2	-0.6	0.3	0.3	1.2
Diastolic blood pressure, automated reading	0.9	2.8	4.3	1.7	2.1	1.8	1.6	1.3	1.5	-1.5
Ever depressed for a whole week	0.3	0.3	1.6	-0.7	-1.2	0.2	0.0	0.0	-0.1	0.5
Unable to work because of sickness or disability	1.0	1.4	2.6	-1.4	-0.9	-0.3	-1.6	-1.0	-0.9	1.5
Commuting to job workplace: Cycle	1.2	1.4	2.7	1.2	1.6	-0.9	0.5	1.3	1.5	-0.7
Myopia	0.2	0.3	1.3	-0.5	0.0	0.1	1.1	-0.6	-0.7	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.6	-0.5	-0.3	-0.3	-0.3	-1.2	-0.9	1.9
Cholesterol lowering medication	0.7	1.0	2.3	0.9	0.9	-0.3	-1.5	1.2	0.7	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.8	1.3	0.7	1.7	0.0	1.3	1.4	-0.8
Pain experienced in last month	0.6	0.9	2.7	1.1	1.2	-0.2	1.6	0.2	0.6	-0.8
Supplements: Calcium	0.8	0.9	2.4	-0.5	-0.5	-0.5	-1.6	-0.9	-0.8	1.3
Basal cell carcinoma (self-reported)	1.8	2.1	2.9	-1.1	-1.1	-1.7	-1.3	-1.6	-1.6	1.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.1	-0.1	-0.7	0.6	0.1	0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.4	0.2	0.3	0.0	-1.2	0.7	0.3	0.0
Heart disease (siblings)	0.2	0.3	0.9	-0.9	-1.0	0.2	-0.3	0.3	0.1	-0.1
Alcohol drinker status: Previous	1.0	1.1	2.1	1.3	1.4	1.0	0.2	1.4	1.0	-0.5
Pack years of smoking	0.6	0.9	1.8	0.8	0.7	1.1	-1.4	1.0	0.8	-0.3
Impedance of whole body	1.0	5.1	10.1	2.7	3.2	0.8	2.3	1.6	1.9	-2.5
Leg fat mass (left)	0.1	0.3	0.9	-0.4	-0.8	0.1	-0.1	0.4	0.1	-0.9
Arm predicted mass (left)	0.2	1.0	3.1	0.4	-0.2	1.0	0.1	1.8	1.0	-1.4