Hub : Genes

KIAA0247

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1380 0.0460 0.00035 0.122 NA 0.042 NA 0.080 3.9e-10 NA 0.00023 NA 4.5e-07
2 GTEx Artery Aorta 0.1510 0.0510 0.00099 0.016 NA 0.024 NA 0.023 4.0e-02 NA 0.01800 NA 2.0e-02
3 GTEx Breast Mammary Tissue 0.1990 0.0690 0.00110 0.016 NA -0.001 NA 0.030 5.0e-02 NA 0.35000 NA 1.1e-02
4 GTEx Breast Mammary Tissue (Male) 0.2549 0.1161 0.01900 0.009 NA -0.013 NA -0.005 1.9e-01 NA 0.89000 NA 4.4e-01
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0251 0.0141 0.00550 0.027 0.018 0.022 NA 0.028 4.0e-04 0.0037 0.00140 NA 3.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.5 0.7 0.6 -0.4 0.4 -0.7
Bipolar Disorder or Schizophrenia 0.6 1.6 3.8 0.7 1.2 -1.9 -1.2 -0.7
Depressed Affect (Nagel 2018) 2.4 5.1 8.8 2.6 -3.0 0.7 1.8 -2.6
Depression (Nagel 2018) 2.4 3.6 6.2 2.3 -2.5 0.3 1.1 -2.3
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 -0.4 0.3 0.2 0.3 0.4
Neuroticism (Nagel 2018) 2.2 5.2 10.4 2.2 -3.2 1.2 2.1 -2.2
Schizophrenia (2018) 0.9 1.9 4.6 0.4 1.1 -2.1 -1.8 -0.4
Schizophrenia vs Biploar Disorder 0.9 1.2 1.9 1.4 -1.2 -0.7 -0.1 -1.4
Worry (Nagel 2018) 3.0 6.4 10.0 2.6 -3.2 1.3 2.6 -2.6
Alzheimer’s Disease (in mother) 0.8 1.0 3.0 0.3 1.7 1.0 0.8 -0.3
Alzheimer’s Disease (in father) 0.2 0.2 0.3 -0.5 -0.0 0.6 0.4 0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 -0.1 1.1 1.2 0.9 0.1
Crohns Disease (2017) 2.0 4.4 9.1 3.0 0.4 1.1 1.6 -3.0
Irritable Bowel Disease (IBD) 1.6 3.9 8.9 3.0 1.1 -0.2 0.7 -3.0
Ulcerative Colitis (UC) 0.8 1.5 2.4 1.3 0.9 -1.6 -0.7 -1.3
Major Depression (MDD) 3.4 4.1 7.7 2.2 -0.1 1.9 2.8 -2.2
Reaction Time 1.4 2.6 3.1 1.8 1.5 1.4 1.7 -1.8
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.7 -0.1 0.1 -0.9 -0.6 0.1
Breast Cancer 0.9 2.2 4.8 -2.2 0.9 0.1 -0.6 2.2
Ovarian Cancer 0.1 0.2 0.3 -0.4 0.5 -0.0 -0.6 0.4
Prostate Cancer 0.6 0.8 1.2 -0.5 -1.0 -1.1 -1.1 0.6
Age at First Birth 0.6 0.9 3.3 0.2 1.8 -0.9 -0.3 -0.2
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.5 0.2 -0.1 0.2 0.5
Body Mass Index (BMI) (2010) 0.6 0.8 1.4 -1.2 0.9 0.1 -0.7 1.2
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.3 -0.6 -0.2 -0.5 0.3
Crohns Disease (2012) 0.8 1.2 2.7 1.6 0.5 0.4 0.5 -1.6
Mean Putamen Volume 0.8 0.9 1.3 -1.1 0.1 -0.9 -1.2 1.1
Fasting Glucose 0.5 0.5 2.0 -0.4 -0.2 0.7 1.4 0.4
HbA1C 0.3 0.3 1.0 0.1 -0.2 -1.0 0.7 -0.1
HDL Cholesterol 0.5 0.9 1.8 -0.3 -0.7 -1.3 -1.4 0.3
LDL Cholesterol 0.3 0.4 0.8 -0.9 -0.6 -0.1 -0.4 0.9
Lupus 1.0 1.5 4.3 -0.8 -2.1 -0.6 -1.2 0.8
Neuroticism (2016) 0.4 0.6 2.6 -0.3 -1.6 -0.4 -0.2 0.3
Primary Biliary Cirrhosis 0.9 1.3 3.0 1.1 0.1 1.0 1.7 -1.1
Rheumatoid Arthritis 1.6 2.2 4.2 0.9 -1.1 1.9 2.1 -0.9
Schizophrenia (2014) 0.4 0.8 1.8 0.7 -0.0 -1.3 -1.2 -0.7
Triglycerides 0.6 0.9 1.5 1.2 -0.8 0.0 1.1 -1.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.6 0.8 -1.3 -0.9 -0.5 -0.8
Ulcerative Colitis 1.2 1.8 3.8 1.9 1.1 -0.5 0.1 -1.9
Blood Eosinophil Count 0.3 2.5 4.3 1.6 2.1 0.8 1.5 -1.6
Blood Platelet Count 0.5 5.8 7.6 2.8 -2.0 1.8 2.5 -2.8
Blood Red Count 1.9 18.5 33.0 4.3 -5.7 3.4 3.3 -4.3
Blood White Count 0.9 6.4 13.2 3.6 -1.1 0.7 2.0 -3.6
Heel T-Score 0.1 0.7 3.3 0.0 0.2 -1.8 -0.5 -0.0
BMI 0.2 1.1 2.3 1.1 -1.5 0.7 0.3 -1.1
Height 0.2 4.2 15.1 0.4 1.8 3.9 1.5 -0.4
Waist Hip Ratio (WHR) 0.6 2.9 6.8 -2.6 0.9 0.1 0.0 2.6
Systolic Blood Pressure 1.6 8.0 12.9 2.3 -1.9 3.6 3.6 -2.3
Smoking Status 0.5 1.2 1.8 1.4 -0.9 0.8 0.9 -1.4
Allergy or Eczema 0.3 0.9 2.0 -1.4 0.3 -0.0 -0.4 1.4
Cardiovascular Disease 1.0 3.4 4.7 1.9 -0.7 2.2 2.1 -1.9
Hypothyroidism (self reported) 0.6 1.3 2.5 -1.3 -1.6 -0.1 -0.7 1.3
Respiratory disease 0.0 0.1 0.3 -0.1 0.4 0.0 -0.5 0.1
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.3 0.1 -0.2 0.3 0.5 -0.1
Lung FEV1/FVC ratio 0.3 1.7 3.1 -1.8 -0.4 -1.2 -0.9 1.8
Lung FVC 0.5 2.5 5.6 -0.8 1.5 -2.4 -1.8 0.8
Neuroticism 2.8 6.8 21.7 2.2 -4.7 0.2 1.4 -2.2
Chronotype (morning person) 0.1 0.3 0.5 0.7 0.4 0.2 0.7 -0.7
Hair Pigment 0.1 3.0 5.6 -2.4 -0.9 -0.8 -1.6 2.4
Tanning 0.1 1.1 1.6 1.0 -0.8 1.3 1.1 -1.0
Hand grip strength (left) 0.6 1.5 4.6 -0.3 -2.2 -1.1 -1.3 0.3
Number of treatments/medications taken 0.5 1.0 3.0 -0.6 -1.7 -0.7 -0.9 0.6
Average weekly spirits intake 0.8 1.0 1.5 -1.1 -0.9 0.1 -1.2 1.1
Sensitivity / hurt feelings 1.4 2.3 11.0 0.0 -3.3 0.7 0.5 -0.0
Frequency of depressed mood in last 2 weeks 2.1 2.9 5.2 2.3 -1.5 0.4 1.2 -2.3
Hearing difficulty/problems: Yes 2.4 3.6 5.2 2.3 0.5 1.9 1.9 -2.3
Relative age of first facial hair 1.0 2.0 2.6 1.5 0.9 1.6 1.4 -1.5
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 4.0 -2.0 0.1 0.5 -0.3 2.0
Ever used hormone-replacement therapy (HRT) 1.0 1.2 3.6 0.5 0.4 1.9 1.3 -0.5
Ever had hysterectomy (womb removed) 1.0 1.1 2.2 -0.8 -1.5 1.4 0.0 0.8
Systolic blood pressure, automated reading 3.6 10.4 16.3 3.4 -1.0 3.4 4.0 -3.4
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 4.4 -0.0 -2.1 -0.8 -0.6 0.0
Angina 0.2 0.2 0.5 -0.4 0.5 -0.3 -0.7 0.4
Medication for hormone replacement therapy 0.4 0.5 1.0 -0.2 -1.0 1.0 0.7 0.2
Vitamin and mineral supplements 0.0 0.0 0.1 0.2 -0.3 0.2 0.3 -0.2
Supplements: Zinc 0.1 0.2 0.7 -0.2 0.8 -0.2 0.1 0.2
Medication: Co-codamol 0.4 0.4 1.2 0.6 0.1 0.5 1.1 -0.6
Medication: Metformin 0.1 0.1 0.2 0.3 0.2 -0.5 -0.1 -0.3
Diabetes (father) 0.3 0.4 0.6 0.8 -0.7 -0.4 -0.2 -0.8
Diabetes (mother) 1.0 1.3 4.7 -0.8 -2.2 -0.2 -0.6 0.8
Severe depression (siblings) 0.2 0.3 0.4 -0.6 0.5 0.1 -0.5 0.6
Pack years adult smoking proportion 0.2 0.2 0.7 0.5 -0.1 0.1 0.8 -0.5
Impedance of leg (right) 0.4 1.9 8.4 -0.2 -2.9 0.5 0.9 0.2
Leg fat-free mass (left) 0.1 0.5 1.9 0.3 1.4 0.7 -0.1 -0.3
Trunk fat percentage 1.0 4.0 5.6 1.8 -2.0 2.4 1.9 -1.8
Hand grip strength (right) 0.4 1.1 2.2 -0.6 -1.0 -1.2 -1.5 0.6
Townsend deprivation index at recruitment 0.2 0.3 0.7 0.4 -0.3 0.5 0.8 -0.4
Current tobacco smoking 0.6 1.0 2.9 -1.0 -1.7 -0.1 -0.3 1.0
Average weekly fortified wine intake 0.0 0.0 0.1 -0.1 0.2 -0.3 -0.3 0.1
Maternal smoking around birth 0.3 0.5 1.1 -1.1 -0.2 -0.0 -0.2 1.1
Fed-up feelings 1.8 3.2 11.8 1.0 -3.4 0.4 1.4 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 9.5 1.0 -3.1 -0.2 0.6 -1.0
Relative age voice broke 2.9 4.4 5.8 2.4 1.7 1.9 1.9 -2.4
Taking other prescription medications 0.3 0.5 1.0 -0.7 -1.0 0.3 -0.2 0.7
Age when periods started (menarche) 2.7 6.4 12.8 -2.0 -1.7 -2.9 -3.6 2.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.6 0.5 -0.6 0.8 0.1 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.5 -0.3 -1.2 -0.1 -0.4 0.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.0 -0.7 -2.0 -0.9 -0.3 0.7
Qualifications: CSEs or equivalent 0.5 0.7 2.9 0.1 -1.7 -0.6 -0.1 -0.1
Serious illness, injury or assault to yourself 0.1 0.1 0.3 -0.3 0.3 0.6 0.3 0.3
High blood pressure 0.2 0.6 1.0 0.9 -1.0 0.3 0.3 -0.9
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 -0.8 -0.5 -0.1 -0.3 0.8
Multivitamins +/- minerals 0.2 0.3 0.5 0.5 -0.6 0.7 0.0 -0.5
Stomach or abdominal pain in last month 0.7 0.8 2.0 -1.4 -0.3 -0.1 -0.3 1.4
Supplements: Glucosamine 0.9 1.2 2.4 -1.0 0.6 -1.2 -1.5 1.0
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.6 -0.6 1.9 -0.3 -0.8 0.6
Medication: Atenolol 0.9 1.2 3.9 -0.1 -0.7 -2.0 -1.2 0.1
Medication: Levothyroxine sodium 0.4 0.7 2.6 -0.0 -1.6 -0.7 -0.7 0.0
Sitting height 0.1 0.6 1.2 -0.2 1.1 0.8 1.0 0.2
Chronic bronchitis/emphysema (father) 1.7 2.0 3.1 1.1 -1.8 1.5 1.5 -1.1
High blood pressure (mother) 0.2 0.2 0.6 0.4 -0.7 0.0 0.6 -0.4
Body mass index (BMI) 0.3 1.3 2.2 1.5 -1.5 -0.0 -0.1 -1.5
Impedance of leg (left) 0.4 2.2 9.1 -0.5 -3.0 0.7 0.9 0.5
Leg predicted mass (left) 0.1 0.6 1.8 0.4 1.3 0.9 0.0 -0.4
Trunk fat mass 0.7 3.1 5.3 1.7 -1.5 2.3 1.6 -1.7
Waist circumference 0.1 0.4 0.5 0.6 -0.7 0.7 0.4 -0.6
Number of incorrect matches in round 0.2 0.4 1.0 0.2 -0.9 1.0 0.3 -0.2
Past tobacco smoking 1.4 2.6 5.9 -2.4 0.5 -0.3 -0.9 2.4
Alcohol usually taken with meals 0.8 1.2 4.3 0.1 2.1 1.0 0.8 -0.1
Nervous feelings 2.7 5.0 15.3 1.8 -3.9 0.0 1.7 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 1.7 1.3 -1.2 0.4 1.3 -1.3
Hearing difficulty/problems with background noise 0.4 0.7 1.0 0.9 1.0 0.6 0.8 -0.9
Hair/balding pattern: Pattern 2 1.2 1.5 2.4 1.4 -1.6 -1.0 -0.2 -1.4
Had menopause 0.6 0.7 1.4 0.7 1.2 0.7 0.8 -0.7
Had other major operations 0.2 0.2 0.3 0.4 -0.5 -0.4 -0.5 -0.4
Forced vital capacity (FVC) 0.4 1.5 4.5 -1.1 2.1 -0.3 -0.6 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.5 -0.1 -1.6 -0.7 -0.2 0.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.0 -0.3 0.8 0.4 1.0 0.3
Qualifications: None of the above 1.1 2.4 4.8 2.2 -1.6 -0.3 0.2 -2.2
Financial difficulties in last 2 years 1.1 1.5 4.7 1.1 -2.2 -0.2 0.6 -1.1
Mouth/teeth dental problems 2.9 4.4 6.5 -2.4 1.5 -1.5 -2.5 2.4
Heart attack 0.7 0.9 4.0 -0.0 -2.0 0.6 0.3 0.0
Allergy 0.1 0.2 0.5 0.4 0.2 -0.0 0.7 -0.4
Pain all over the body in last month 0.2 0.2 0.4 0.6 -0.6 -0.3 0.2 -0.6
Diabetes (self-reported) 0.3 0.4 0.7 0.7 -0.8 0.0 0.8 -0.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.7 -0.1 -1.6 -0.3 -0.1 0.1
Medication: Ramipril 0.6 0.8 1.1 0.9 -0.7 1.0 1.0 -0.9
Medication: Simvastatin 0.1 0.1 0.3 0.5 0.2 0.0 0.4 -0.5
Fluid intelligence score 0.3 0.6 0.8 -0.8 0.8 -0.9 -0.7 0.8
Illnesses of siblings 0.4 0.5 1.1 0.5 0.6 -1.1 -0.8 -0.5
Neuroticism score 2.1 4.3 15.0 1.6 -3.9 0.2 1.3 -1.6
Weight 0.2 1.1 1.6 1.3 -0.5 1.3 0.5 -1.3
Impedance of arm (right) 1.1 5.3 14.4 0.8 0.1 3.8 3.3 -0.8
Arm fat percentage (right) 0.8 3.2 3.6 1.9 -1.9 1.8 1.4 -1.9
Trunk fat-free mass 0.1 0.4 0.9 -0.5 0.9 0.1 -0.7 0.5
Hip circumference 0.7 3.1 4.4 2.0 -1.0 2.1 1.5 -2.0
Time employed in main current job 0.9 1.0 1.8 -1.4 1.1 -0.2 -0.4 1.4
Alcohol intake versus 10 years previously 0.9 1.3 2.3 1.5 -0.2 -1.4 0.0 -1.5
Father’s age at death 0.4 0.5 1.7 -0.6 0.3 -0.3 -1.3 0.6
Worrier / anxious feelings 2.0 3.7 5.2 1.5 -2.3 1.9 2.3 -1.5
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.5 17.3 0.1 -4.2 -0.3 0.3 -0.1
Falls in the last year 0.5 0.7 3.1 0.5 1.8 0.2 -0.1 -0.5
Hair/balding pattern: Pattern 3 0.4 0.5 0.8 -0.5 0.9 0.8 0.8 0.5
Number of live births 0.0 0.1 0.1 -0.1 0.3 0.3 0.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 2.4 -1.4 1.6 -0.9 -1.0 1.4
Pulse rate 1.3 2.1 9.5 -0.2 -3.1 0.5 0.9 0.2
Happiness 4.0 4.8 9.2 2.3 -0.1 2.0 3.0 -2.3
Noisy workplace 1.2 1.5 1.9 1.4 -1.4 0.6 1.1 -1.4
Qualifications: A levels/AS levels or equivalent 2.3 5.1 10.6 -2.6 3.3 -0.4 -1.1 2.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 -0.4 0.2 -0.7 0.2 0.4
Mouth/teeth dental problems: Dentures 1.8 3.0 3.7 1.5 -1.9 1.9 1.9 -1.5
Asthma 0.1 0.2 0.7 0.0 0.1 -0.3 -0.8 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.9 0.0 -0.4 0.8 0.9 -0.0
Medication: Cholesterol lowering 0.8 1.3 3.1 -1.1 -1.8 -0.5 -0.6 1.1
Depression (self-reported) 1.5 1.8 3.9 -0.2 1.6 2.0 1.5 0.2
Medication: Lansoprazole 2.2 2.5 10.7 0.9 -3.3 -0.1 0.2 -0.9
Prospective memory result 1.5 1.8 3.0 1.2 -0.7 1.7 1.7 -1.2
Lung cancer (father) 0.4 0.5 1.0 1.0 -0.1 0.4 0.4 -1.0
Illnesses of mother 0.3 0.4 1.2 0.6 1.1 -0.3 -0.0 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.9 -1.6 2.0 -0.6 -0.8 1.6
Pulse wave Arterial Stiffness index 1.1 1.2 2.1 1.1 -0.6 1.5 1.0 -1.1
Impedance of arm (left) 0.9 3.9 11.1 0.4 0.4 3.3 2.8 -0.4
Arm fat mass (right) 0.5 1.9 2.4 1.6 -1.1 1.5 1.1 -1.6
Trunk predicted mass 0.1 0.5 0.8 -0.6 0.9 -0.0 -0.8 0.6
Standing height 0.4 3.7 9.9 -0.1 2.4 3.1 1.7 0.1
Length of working week for main job 0.1 0.2 0.4 -0.3 0.6 -0.2 -0.3 0.3
Exposure to tobacco smoke at home 1.1 1.3 3.4 -0.6 0.2 1.8 1.4 0.6
Breastfed as a baby 0.7 0.9 1.2 -1.1 -1.0 -0.5 -0.8 1.1
Tense / ‘highly strung’ 0.4 0.7 1.4 0.5 -1.2 0.6 1.0 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 5.0 0.2 -2.2 0.3 0.4 -0.2
Hair/balding pattern: Pattern 4 2.7 6.5 14.6 -3.8 0.6 0.0 -1.7 3.8
Birth weight of first child 1.0 1.9 4.0 -0.6 -1.2 -1.8 -2.0 0.6
Peak expiratory flow (PEF) 0.8 1.9 2.6 -1.5 -0.2 -1.4 -1.6 1.5
Pulse wave reflection index 0.7 0.9 1.3 1.2 1.1 0.6 0.3 -1.2
Ever highly irritable/argumentative for 2 days 1.9 2.3 3.2 1.6 -1.2 1.3 1.8 -1.6
Loud music exposure frequency 0.2 0.2 0.3 -0.6 -0.1 -0.2 -0.3 0.6
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 3.7 -1.9 1.3 -0.8 -1.4 1.9
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 2.6 1.6 0.4 0.8 1.5 -1.6
Blood clot in the leg (DVT) 0.4 0.5 1.2 -0.7 -1.1 0.4 -0.3 0.7
Medication: Paracetamol 1.5 2.5 10.4 -0.4 -3.2 -1.3 -0.2 0.4
Headache pain in last month 2.6 4.4 15.8 -0.8 -4.0 -2.1 -0.7 0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.8 0.1 1.4 -0.3 -0.0 -0.1
Glaucoma (self-reported) 0.2 0.3 0.5 -0.4 0.6 -0.7 -0.3 0.4
Gout (self-reported) 0.1 0.2 0.8 0.3 0.9 0.2 -0.0 -0.3
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 2.4 -1.2 -1.5 -1.4 -1.4 1.2
Medication: Amlodipine 0.7 1.0 4.4 -0.0 2.1 0.7 0.2 0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.1 0.5 1.0 0.9 0.7 -0.5
Birth weight 1.1 2.3 3.2 -1.8 1.4 -1.0 -1.5 1.8
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.5 -1.6 0.5 -0.7 -1.0 1.6
High blood pressure (siblings) 1.4 2.0 5.9 0.3 0.2 2.4 2.0 -0.3
Forced vital capacity (FVC), Best measure 0.4 1.4 4.7 -1.0 2.2 -0.2 -0.6 1.0
Body fat percentage 0.8 3.0 6.3 1.5 -2.5 1.7 1.2 -1.5
Leg fat percentage (right) 0.7 2.6 10.9 1.0 -3.3 0.3 0.1 -1.0
Arm fat-free mass (right) 0.2 0.9 2.2 -0.8 0.6 -0.8 -1.5 0.8
Exposure to tobacco smoke outside home 0.6 0.8 1.7 -1.3 -0.1 -0.4 -0.7 1.3
Comparative body size at age 10 0.8 2.1 7.9 -1.1 2.8 -0.0 -0.5 1.1
Number of full brothers 0.5 0.7 1.6 0.7 -1.3 -0.8 -0.4 -0.7
Worry too long after embarrassment 0.1 0.2 0.9 -0.1 -0.9 0.2 -0.1 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 2.4 1.6 -1.3 0.2 1.2 -1.6
Wheeze or whistling in the chest in last year 1.3 2.4 5.3 -1.1 -0.6 -2.3 -1.9 1.1
Number of children fathered 0.4 0.5 1.2 -0.4 -1.1 0.9 0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 4.5 -0.6 2.1 -0.5 -0.8 0.6
Age at first live birth 0.5 0.9 3.8 -0.0 2.0 -0.8 -0.5 0.0
Pulse wave peak to peak time 1.3 1.6 2.4 -1.3 0.8 -1.6 -1.2 1.3
Health satisfaction 1.8 2.3 3.3 1.8 -0.9 1.0 1.8 -1.8
Shortness of breath walking on level ground 1.2 1.4 2.5 -0.9 -1.5 -1.6 -0.9 0.9
Qualifications: College or University degree 2.4 7.4 21.2 -2.7 4.6 -0.1 -1.1 2.7
Eye problems/disorders: None of the above 0.2 0.3 0.6 0.1 0.7 0.8 0.4 -0.1
Mouth/teeth dental problems: Loose teeth 0.9 1.0 2.1 1.2 -0.0 0.5 1.5 -1.2
Emphysema/chronic bronchitis 0.5 0.5 1.3 0.2 -0.4 -1.1 -1.1 -0.2
Medication for pain relief, constipation, heartburn 1.1 1.9 7.8 0.1 2.8 1.2 0.4 -0.1
Neck or shoulder pain in last month 4.5 6.4 12.0 -1.0 -3.3 -3.5 -2.6 1.0
Medication: Blood pressure 0.2 0.3 0.6 0.5 -0.8 0.2 0.3 -0.5
Angina (self-reported) 0.2 0.3 0.8 -0.4 0.6 -0.3 -0.9 0.4
Migraine (self-reported) 0.2 0.3 0.6 -0.5 -0.2 0.5 0.8 0.5
Medication: Ibuprofen 0.3 0.4 0.9 -0.2 -1.0 0.5 0.8 0.2
Medication: Allopurinol 0.4 0.5 1.1 -0.3 -0.1 -1.1 -1.0 0.3
Medication: Omeprazole 2.6 3.1 6.0 -2.5 -0.4 -1.1 -1.5 2.5
Medication: Seretide 50 evohaler 2.2 2.5 3.1 1.7 1.1 1.8 1.6 -1.7
Mean time to correctly identify matches 2.6 4.9 7.5 2.7 1.4 1.8 2.1 -2.7
Heart disease (mother) 0.9 1.1 1.8 -1.2 1.4 0.6 -0.3 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.3 -0.5 -1.5 -0.8 -0.6 0.5
Whole body fat mass 0.4 1.8 2.7 1.2 -1.7 1.6 0.9 -1.2
Leg fat mass (right) 0.3 1.1 4.0 0.9 -2.0 0.3 -0.2 -0.9
Arm predicted mass (right) 0.1 0.7 1.7 -0.7 0.3 -0.6 -1.3 0.7
Pulse rate, automated reading 0.7 2.3 4.5 -2.1 -1.3 -0.7 -0.6 2.1
Alcohol intake frequency. 0.9 2.1 3.9 -0.9 -2.0 -1.6 -1.7 0.9
Comparative height size at age 10 0.4 2.2 5.1 0.4 2.3 2.1 1.2 -0.4
Number of full sisters 0.6 0.7 2.3 0.6 -0.3 -1.5 -0.7 -0.6
Suffer from ‘nerves’ 1.4 2.1 3.1 1.5 -1.7 0.5 1.8 -1.5
Overall health rating 0.6 1.3 6.3 0.0 -2.5 0.1 0.1 -0.0
Chest pain or discomfort 0.5 0.7 1.8 0.8 -1.4 0.6 0.4 -0.8
Had major operations 0.2 0.3 0.6 0.2 0.4 0.8 0.7 -0.2
Age at last live birth 0.6 0.8 1.3 -0.7 1.1 -1.0 -1.0 0.7
Family relationship satisfaction 2.9 3.5 5.4 2.3 -0.1 1.6 2.0 -2.3
Leg pain on walking 0.8 0.9 3.4 0.0 -1.8 0.8 0.9 -0.0
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 4.8 1.2 -2.2 -0.2 0.0 -1.2
Commuting to job workplace: Car/motor vehicle 0.7 0.9 1.3 -1.1 -1.1 0.3 -0.7 1.1
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 2.5 -1.6 1.3 -0.6 -1.1 1.6
Medication: Aspirin 0.1 0.1 0.3 0.2 -0.5 -0.4 -0.3 -0.2
Supplements: Vitamin C 0.7 0.9 1.4 -0.9 0.1 -1.2 -1.1 0.9
Knee pain experienced in last month 1.0 1.6 4.9 1.0 -2.2 -0.9 -0.6 -1.0
Hypertension (Self-reported) 0.3 0.7 1.3 1.1 -0.6 0.6 0.6 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 2.1 1.3 -1.1 1.4 1.3 -1.3
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.7 0.2 -0.3 -0.9 0.7
Illnesses of siblings: Diabetes 0.7 0.9 4.2 -0.1 -2.0 0.2 -0.2 0.1
Smoking status: Previous 2.5 3.7 8.1 2.9 -0.2 0.6 1.3 -2.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.4 0.1 0.2 2.1 1.3 -0.1
Whole body fat-free mass 0.1 0.3 1.1 -0.1 1.0 0.3 -0.5 0.1
Leg fat-free mass (right) 0.1 0.6 2.4 0.1 1.5 0.9 -0.1 -0.1
Arm fat percentage (left) 0.5 2.0 2.7 1.5 -1.7 1.4 1.0 -1.5
Average weekly red wine intake 0.2 0.3 1.6 0.0 1.3 -0.2 -0.1 -0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.0 -1.0 0.3 0.2 -0.5 1.0
Mood swings 1.3 2.4 5.3 1.5 -2.3 0.9 1.2 -1.5
Loneliness, isolation 0.5 0.7 1.5 0.7 -1.2 0.3 0.9 -0.7
Long-standing illness, disability or infirmity 0.5 0.8 3.1 -0.5 -1.8 -0.2 -0.4 0.5
Ever had bowel cancer screening 1.3 1.5 3.6 0.7 -0.6 1.9 1.6 -0.7
Diabetes diagnosed by doctor 0.2 0.4 0.7 0.5 -0.9 0.2 0.8 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.2 0.4 -0.4 -0.4 -0.2
Friendships satisfaction 0.9 1.1 2.3 1.5 -0.3 0.1 0.9 -1.5
Qualifications: nursing, teaching 6.0 9.4 15.8 -4.0 3.2 -1.0 -2.1 4.0
Commuting to job workplace: Walk 0.7 0.8 1.1 1.1 0.9 -0.2 0.8 -1.1
Eye problems/disorders: Cataract 0.7 0.8 1.2 1.0 0.9 -1.1 -0.4 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 3.0 1.6 -0.3 0.1 1.7 -1.6
Medication for cholesterol 0.1 0.2 0.5 -0.4 0.7 0.0 -0.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 3.1 -1.8 -0.8 -1.3 -1.8 1.8
Back pain experienced in last month 1.0 1.4 5.8 0.8 -2.4 0.0 0.1 -0.8
Mineral and other dietary supplements 0.7 1.0 4.5 0.3 -2.1 -0.0 0.3 -0.3
Breast cancer (self-reported) 1.5 1.8 2.7 1.4 -1.7 0.6 1.3 -1.4
Asthma (self-reported) 0.1 0.1 0.4 0.2 -0.3 -0.0 -0.6 -0.2
Osteoporosis (self-reported) 1.4 1.7 5.0 0.9 2.2 1.3 0.6 -0.9
Osteoarthritis (self-reported) 0.6 0.8 1.1 1.1 -0.9 0.7 0.8 -1.1
Medication: Aspirin 0.0 0.0 0.1 0.1 0.1 -0.2 -0.4 -0.1
Medication: Gliclazide 0.8 0.9 1.7 0.8 0.5 1.1 1.3 -0.8
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 -0.4 0.9 0.7 0.7 0.4
Smoking status: Current 0.5 0.7 2.7 -0.7 -1.6 -0.0 -0.3 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 6.0 -2.4 -0.2 -0.8 -1.3 2.4
Whole body water mass 0.1 0.3 1.1 -0.1 1.1 0.2 -0.5 0.1
Leg predicted mass (right) 0.1 0.8 2.9 0.1 1.7 1.0 -0.0 -0.1
Arm fat mass (left) 0.3 1.3 1.8 1.2 -1.3 1.1 0.6 -1.2
Number of self-reported non-cancer illnesses 0.6 1.1 4.9 0.0 -2.2 0.7 -0.1 -0.0
Average weekly champagne plus white wine intake 1.3 1.9 6.7 -0.8 2.6 -0.7 -0.8 0.8
Miserableness 0.8 1.4 6.1 0.4 -2.5 -0.6 0.3 -0.4
Guilty feelings 0.5 0.7 1.2 1.0 -1.1 -0.3 0.6 -1.0
Wears glasses or contact lenses 0.4 0.5 1.3 -0.0 0.4 1.1 0.9 0.0
Ever taken oral contraceptive pill 0.6 0.7 1.6 -1.2 0.3 -0.1 -0.4 1.2
Hearing aid user 0.3 0.4 0.8 -0.9 0.2 0.1 -0.6 0.9
Mother’s age at death 0.3 0.4 0.6 0.8 -0.8 0.1 -0.2 -0.8
Financial situation satisfaction 1.3 1.7 5.0 1.0 -2.2 0.3 1.2 -1.0
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.6 -0.1 -0.8 -0.4 -0.8 0.1
Commuting to job workplace: Public transport 1.7 2.0 9.0 0.6 3.0 0.3 0.3 -0.6
Eye problems/disorders: Glaucoma 0.2 0.3 0.3 -0.6 -0.3 -0.6 -0.6 0.6
Medication: Blood pressure 0.3 0.6 1.2 0.3 -1.0 1.1 0.9 -0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.1 -0.4 -1.4 0.6 0.5 0.4
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.5 0.1 1.9 -0.7 -0.7 -0.1
High cholesterol (Self-reported) 0.3 0.6 1.0 1.0 -0.7 0.0 0.8 -1.0
Medication: Bendroflumethiazide 0.5 0.7 1.5 0.2 -1.2 1.2 0.7 -0.2
Medication: Paracetamol 1.5 2.3 8.8 -0.4 -3.0 -1.5 -0.3 0.4
Medication: Lisinopril 0.2 0.2 0.4 -0.7 -0.2 0.2 -0.2 0.7
Medication: Atorvastatin 1.1 1.4 2.3 -1.4 -0.2 -0.9 -1.5 1.4
Illnesses of father: High blood pressure 0.2 0.2 0.6 -0.8 0.1 0.1 0.1 0.8
Alcohol drinker status: Never 0.3 0.3 0.8 -0.9 0.4 -0.0 -0.3 0.9
Ever smoked 0.4 0.7 1.2 1.1 -0.6 0.5 0.7 -1.1
Basal metabolic rate 0.0 0.2 0.5 0.2 0.7 0.5 -0.2 -0.2
Leg fat percentage (left) 0.6 2.4 10.9 0.6 -3.3 0.4 -0.0 -0.6
Arm fat-free mass (left) 0.0 0.1 0.6 -0.1 0.0 -0.2 -0.8 0.1
Number of operations (self-reported) 0.1 0.2 0.5 -0.2 -0.6 -0.4 -0.7 0.2
Average weekly beer plus cider intake 0.7 1.0 3.9 0.8 -2.0 -0.1 -0.1 -0.8
Irritability 0.1 0.2 1.0 0.2 -1.0 -0.0 0.4 -0.2
Risk taking 0.1 0.1 0.6 0.0 0.8 0.1 -0.4 -0.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.8 -1.4 0.7 0.2 -0.7 1.4
Fractured/broken bones in last 5 years 1.9 2.4 3.2 1.8 1.1 1.5 1.4 -1.8
Age started oral contraceptive pill 2.5 3.2 4.5 -1.7 1.5 -1.9 -2.1 1.7
Diastolic blood pressure, automated reading 3.3 10.2 12.9 3.5 -2.5 2.7 3.6 -3.5
Ever depressed for a whole week 0.3 0.3 0.7 -0.0 -0.7 0.6 0.9 0.0
Unable to work because of sickness or disability 0.8 1.0 1.7 -1.3 -0.1 -0.9 -0.8 1.3
Commuting to job workplace: Cycle 1.1 1.3 2.0 1.4 1.4 -0.7 0.4 -1.4
Myopia 1.0 1.5 3.5 0.8 -0.1 1.6 1.9 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.9 -0.5 1.4 -0.5 -0.3 0.5
Cholesterol lowering medication 0.7 1.0 1.5 1.2 1.1 0.6 0.8 -1.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.8 -1.7 -1.1 0.2 -0.2 1.7
Pain experienced in last month 2.3 3.8 11.4 0.2 3.4 2.5 1.1 -0.2
Supplements: Calcium 0.5 0.5 1.1 -1.1 0.0 -0.2 -0.4 1.1
Basal cell carcinoma (self-reported) 0.7 0.9 2.5 0.0 -1.0 -1.6 -0.9 -0.0
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.3 -0.0 -1.8 0.8 0.6 0.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.7 -0.5 -0.7 0.9 -0.0 0.5
Heart disease (siblings) 0.8 1.0 2.0 -0.9 -0.7 -0.9 -1.4 0.9
Alcohol drinker status: Previous 0.9 1.0 1.4 -1.2 0.8 -0.4 -1.1 1.2
Pack years of smoking 0.3 0.4 1.3 0.6 0.4 0.4 1.1 -0.6
Impedance of whole body 0.6 3.1 7.4 0.1 -1.3 2.7 2.5 -0.1
Leg fat mass (left) 0.2 1.0 3.7 0.7 -1.9 0.5 -0.2 -0.7
Arm predicted mass (left) 0.0 0.1 0.6 -0.1 0.2 -0.3 -0.8 0.1