Hub : Genes

KIAA0247

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1380	0.0460	0.00035	0.122	NA	0.042	NA	0.080	3.9e-10	NA	0.00023	NA	4.5e-07
2	GTEx	Artery Aorta	0.1510	0.0510	0.00099	0.016	NA	0.024	NA	0.023	4.0e-02	NA	0.01800	NA	2.0e-02
3	GTEx	Breast Mammary Tissue	0.1990	0.0690	0.00110	0.016	NA	-0.001	NA	0.030	5.0e-02	NA	0.35000	NA	1.1e-02
4	GTEx	Breast Mammary Tissue (Male)	0.2549	0.1161	0.01900	0.009	NA	-0.013	NA	-0.005	1.9e-01	NA	0.89000	NA	4.4e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0251	0.0141	0.00550	0.027	0.018	0.022	NA	0.028	4.0e-04	0.0037	0.00140	NA	3.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	0.6	-0.4	0.4	-0.7
Bipolar Disorder or Schizophrenia	0.6	1.6	3.8	0.7	1.2	-1.9	-1.2	-0.7
Depressed Affect (Nagel 2018)	2.4	5.1	8.8	2.6	-3.0	0.7	1.8	-2.6
Depression (Nagel 2018)	2.4	3.6	6.2	2.3	-2.5	0.3	1.1	-2.3
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.4	0.3	0.2	0.3	0.4
Neuroticism (Nagel 2018)	2.2	5.2	10.4	2.2	-3.2	1.2	2.1	-2.2
Schizophrenia (2018)	0.9	1.9	4.6	0.4	1.1	-2.1	-1.8	-0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	1.9	1.4	-1.2	-0.7	-0.1	-1.4
Worry (Nagel 2018)	3.0	6.4	10.0	2.6	-3.2	1.3	2.6	-2.6
Alzheimer’s Disease (in mother)	0.8	1.0	3.0	0.3	1.7	1.0	0.8	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	-0.0	0.6	0.4	0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-0.1	1.1	1.2	0.9	0.1
Crohns Disease (2017)	2.0	4.4	9.1	3.0	0.4	1.1	1.6	-3.0
Irritable Bowel Disease (IBD)	1.6	3.9	8.9	3.0	1.1	-0.2	0.7	-3.0
Ulcerative Colitis (UC)	0.8	1.5	2.4	1.3	0.9	-1.6	-0.7	-1.3
Major Depression (MDD)	3.4	4.1	7.7	2.2	-0.1	1.9	2.8	-2.2
Reaction Time	1.4	2.6	3.1	1.8	1.5	1.4	1.7	-1.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.7	-0.1	0.1	-0.9	-0.6	0.1
Breast Cancer	0.9	2.2	4.8	-2.2	0.9	0.1	-0.6	2.2
Ovarian Cancer	0.1	0.2	0.3	-0.4	0.5	-0.0	-0.6	0.4
Prostate Cancer	0.6	0.8	1.2	-0.5	-1.0	-1.1	-1.1	0.6
Age at First Birth	0.6	0.9	3.3	0.2	1.8	-0.9	-0.3	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.5	0.2	-0.1	0.2	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	-1.2	0.9	0.1	-0.7	1.2
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.3	-0.6	-0.2	-0.5	0.3
Crohns Disease (2012)	0.8	1.2	2.7	1.6	0.5	0.4	0.5	-1.6
Mean Putamen Volume	0.8	0.9	1.3	-1.1	0.1	-0.9	-1.2	1.1
Fasting Glucose	0.5	0.5	2.0	-0.4	-0.2	0.7	1.4	0.4
HbA1C	0.3	0.3	1.0	0.1	-0.2	-1.0	0.7	-0.1
HDL Cholesterol	0.5	0.9	1.8	-0.3	-0.7	-1.3	-1.4	0.3
LDL Cholesterol	0.3	0.4	0.8	-0.9	-0.6	-0.1	-0.4	0.9
Lupus	1.0	1.5	4.3	-0.8	-2.1	-0.6	-1.2	0.8
Neuroticism (2016)	0.4	0.6	2.6	-0.3	-1.6	-0.4	-0.2	0.3
Primary Biliary Cirrhosis	0.9	1.3	3.0	1.1	0.1	1.0	1.7	-1.1
Rheumatoid Arthritis	1.6	2.2	4.2	0.9	-1.1	1.9	2.1	-0.9
Schizophrenia (2014)	0.4	0.8	1.8	0.7	-0.0	-1.3	-1.2	-0.7
Triglycerides	0.6	0.9	1.5	1.2	-0.8	0.0	1.1	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	0.8	-1.3	-0.9	-0.5	-0.8
Ulcerative Colitis	1.2	1.8	3.8	1.9	1.1	-0.5	0.1	-1.9
Blood Eosinophil Count	0.3	2.5	4.3	1.6	2.1	0.8	1.5	-1.6
Blood Platelet Count	0.5	5.8	7.6	2.8	-2.0	1.8	2.5	-2.8
Blood Red Count	1.9	18.5	33.0	4.3	-5.7	3.4	3.3	-4.3
Blood White Count	0.9	6.4	13.2	3.6	-1.1	0.7	2.0	-3.6
Heel T-Score	0.1	0.7	3.3	0.0	0.2	-1.8	-0.5	-0.0
BMI	0.2	1.1	2.3	1.1	-1.5	0.7	0.3	-1.1
Height	0.2	4.2	15.1	0.4	1.8	3.9	1.5	-0.4
Waist Hip Ratio (WHR)	0.6	2.9	6.8	-2.6	0.9	0.1	0.0	2.6
Systolic Blood Pressure	1.6	8.0	12.9	2.3	-1.9	3.6	3.6	-2.3
Smoking Status	0.5	1.2	1.8	1.4	-0.9	0.8	0.9	-1.4
Allergy or Eczema	0.3	0.9	2.0	-1.4	0.3	-0.0	-0.4	1.4
Cardiovascular Disease	1.0	3.4	4.7	1.9	-0.7	2.2	2.1	-1.9
Hypothyroidism (self reported)	0.6	1.3	2.5	-1.3	-1.6	-0.1	-0.7	1.3
Respiratory disease	0.0	0.1	0.3	-0.1	0.4	0.0	-0.5	0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	0.1	-0.2	0.3	0.5	-0.1
Lung FEV1/FVC ratio	0.3	1.7	3.1	-1.8	-0.4	-1.2	-0.9	1.8
Lung FVC	0.5	2.5	5.6	-0.8	1.5	-2.4	-1.8	0.8
Neuroticism	2.8	6.8	21.7	2.2	-4.7	0.2	1.4	-2.2
Chronotype (morning person)	0.1	0.3	0.5	0.7	0.4	0.2	0.7	-0.7
Hair Pigment	0.1	3.0	5.6	-2.4	-0.9	-0.8	-1.6	2.4
Tanning	0.1	1.1	1.6	1.0	-0.8	1.3	1.1	-1.0
Hand grip strength (left)	0.6	1.5	4.6	-0.3	-2.2	-1.1	-1.3	0.3
Number of treatments/medications taken	0.5	1.0	3.0	-0.6	-1.7	-0.7	-0.9	0.6
Average weekly spirits intake	0.8	1.0	1.5	-1.1	-0.9	0.1	-1.2	1.1
Sensitivity / hurt feelings	1.4	2.3	11.0	0.0	-3.3	0.7	0.5	-0.0
Frequency of depressed mood in last 2 weeks	2.1	2.9	5.2	2.3	-1.5	0.4	1.2	-2.3
Hearing difficulty/problems: Yes	2.4	3.6	5.2	2.3	0.5	1.9	1.9	-2.3
Relative age of first facial hair	1.0	2.0	2.6	1.5	0.9	1.6	1.4	-1.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.0	-2.0	0.1	0.5	-0.3	2.0
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.6	0.5	0.4	1.9	1.3	-0.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	-0.8	-1.5	1.4	0.0	0.8
Systolic blood pressure, automated reading	3.6	10.4	16.3	3.4	-1.0	3.4	4.0	-3.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	4.4	-0.0	-2.1	-0.8	-0.6	0.0
Angina	0.2	0.2	0.5	-0.4	0.5	-0.3	-0.7	0.4
Medication for hormone replacement therapy	0.4	0.5	1.0	-0.2	-1.0	1.0	0.7	0.2
Vitamin and mineral supplements	0.0	0.0	0.1	0.2	-0.3	0.2	0.3	-0.2
Supplements: Zinc	0.1	0.2	0.7	-0.2	0.8	-0.2	0.1	0.2
Medication: Co-codamol	0.4	0.4	1.2	0.6	0.1	0.5	1.1	-0.6
Medication: Metformin	0.1	0.1	0.2	0.3	0.2	-0.5	-0.1	-0.3
Diabetes (father)	0.3	0.4	0.6	0.8	-0.7	-0.4	-0.2	-0.8
Diabetes (mother)	1.0	1.3	4.7	-0.8	-2.2	-0.2	-0.6	0.8
Severe depression (siblings)	0.2	0.3	0.4	-0.6	0.5	0.1	-0.5	0.6
Pack years adult smoking proportion	0.2	0.2	0.7	0.5	-0.1	0.1	0.8	-0.5
Impedance of leg (right)	0.4	1.9	8.4	-0.2	-2.9	0.5	0.9	0.2
Leg fat-free mass (left)	0.1	0.5	1.9	0.3	1.4	0.7	-0.1	-0.3
Trunk fat percentage	1.0	4.0	5.6	1.8	-2.0	2.4	1.9	-1.8
Hand grip strength (right)	0.4	1.1	2.2	-0.6	-1.0	-1.2	-1.5	0.6
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.4	-0.3	0.5	0.8	-0.4
Current tobacco smoking	0.6	1.0	2.9	-1.0	-1.7	-0.1	-0.3	1.0
Average weekly fortified wine intake	0.0	0.0	0.1	-0.1	0.2	-0.3	-0.3	0.1
Maternal smoking around birth	0.3	0.5	1.1	-1.1	-0.2	-0.0	-0.2	1.1
Fed-up feelings	1.8	3.2	11.8	1.0	-3.4	0.4	1.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	9.5	1.0	-3.1	-0.2	0.6	-1.0
Relative age voice broke	2.9	4.4	5.8	2.4	1.7	1.9	1.9	-2.4
Taking other prescription medications	0.3	0.5	1.0	-0.7	-1.0	0.3	-0.2	0.7
Age when periods started (menarche)	2.7	6.4	12.8	-2.0	-1.7	-2.9	-3.6	2.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.5	-0.6	0.8	0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.5	-0.3	-1.2	-0.1	-0.4	0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.0	-0.7	-2.0	-0.9	-0.3	0.7
Qualifications: CSEs or equivalent	0.5	0.7	2.9	0.1	-1.7	-0.6	-0.1	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.3	0.3	0.6	0.3	0.3
High blood pressure	0.2	0.6	1.0	0.9	-1.0	0.3	0.3	-0.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.8	-0.5	-0.1	-0.3	0.8
Multivitamins +/- minerals	0.2	0.3	0.5	0.5	-0.6	0.7	0.0	-0.5
Stomach or abdominal pain in last month	0.7	0.8	2.0	-1.4	-0.3	-0.1	-0.3	1.4
Supplements: Glucosamine	0.9	1.2	2.4	-1.0	0.6	-1.2	-1.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.6	-0.6	1.9	-0.3	-0.8	0.6
Medication: Atenolol	0.9	1.2	3.9	-0.1	-0.7	-2.0	-1.2	0.1
Medication: Levothyroxine sodium	0.4	0.7	2.6	-0.0	-1.6	-0.7	-0.7	0.0
Sitting height	0.1	0.6	1.2	-0.2	1.1	0.8	1.0	0.2
Chronic bronchitis/emphysema (father)	1.7	2.0	3.1	1.1	-1.8	1.5	1.5	-1.1
High blood pressure (mother)	0.2	0.2	0.6	0.4	-0.7	0.0	0.6	-0.4
Body mass index (BMI)	0.3	1.3	2.2	1.5	-1.5	-0.0	-0.1	-1.5
Impedance of leg (left)	0.4	2.2	9.1	-0.5	-3.0	0.7	0.9	0.5
Leg predicted mass (left)	0.1	0.6	1.8	0.4	1.3	0.9	0.0	-0.4
Trunk fat mass	0.7	3.1	5.3	1.7	-1.5	2.3	1.6	-1.7
Waist circumference	0.1	0.4	0.5	0.6	-0.7	0.7	0.4	-0.6
Number of incorrect matches in round	0.2	0.4	1.0	0.2	-0.9	1.0	0.3	-0.2
Past tobacco smoking	1.4	2.6	5.9	-2.4	0.5	-0.3	-0.9	2.4
Alcohol usually taken with meals	0.8	1.2	4.3	0.1	2.1	1.0	0.8	-0.1
Nervous feelings	2.7	5.0	15.3	1.8	-3.9	0.0	1.7	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	1.7	1.3	-1.2	0.4	1.3	-1.3
Hearing difficulty/problems with background noise	0.4	0.7	1.0	0.9	1.0	0.6	0.8	-0.9
Hair/balding pattern: Pattern 2	1.2	1.5	2.4	1.4	-1.6	-1.0	-0.2	-1.4
Had menopause	0.6	0.7	1.4	0.7	1.2	0.7	0.8	-0.7
Had other major operations	0.2	0.2	0.3	0.4	-0.5	-0.4	-0.5	-0.4
Forced vital capacity (FVC)	0.4	1.5	4.5	-1.1	2.1	-0.3	-0.6	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.5	-0.1	-1.6	-0.7	-0.2	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.3	0.8	0.4	1.0	0.3
Qualifications: None of the above	1.1	2.4	4.8	2.2	-1.6	-0.3	0.2	-2.2
Financial difficulties in last 2 years	1.1	1.5	4.7	1.1	-2.2	-0.2	0.6	-1.1
Mouth/teeth dental problems	2.9	4.4	6.5	-2.4	1.5	-1.5	-2.5	2.4
Heart attack	0.7	0.9	4.0	-0.0	-2.0	0.6	0.3	0.0
Allergy	0.1	0.2	0.5	0.4	0.2	-0.0	0.7	-0.4
Pain all over the body in last month	0.2	0.2	0.4	0.6	-0.6	-0.3	0.2	-0.6
Diabetes (self-reported)	0.3	0.4	0.7	0.7	-0.8	0.0	0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.7	-0.1	-1.6	-0.3	-0.1	0.1
Medication: Ramipril	0.6	0.8	1.1	0.9	-0.7	1.0	1.0	-0.9
Medication: Simvastatin	0.1	0.1	0.3	0.5	0.2	0.0	0.4	-0.5
Fluid intelligence score	0.3	0.6	0.8	-0.8	0.8	-0.9	-0.7	0.8
Illnesses of siblings	0.4	0.5	1.1	0.5	0.6	-1.1	-0.8	-0.5
Neuroticism score	2.1	4.3	15.0	1.6	-3.9	0.2	1.3	-1.6
Weight	0.2	1.1	1.6	1.3	-0.5	1.3	0.5	-1.3
Impedance of arm (right)	1.1	5.3	14.4	0.8	0.1	3.8	3.3	-0.8
Arm fat percentage (right)	0.8	3.2	3.6	1.9	-1.9	1.8	1.4	-1.9
Trunk fat-free mass	0.1	0.4	0.9	-0.5	0.9	0.1	-0.7	0.5
Hip circumference	0.7	3.1	4.4	2.0	-1.0	2.1	1.5	-2.0
Time employed in main current job	0.9	1.0	1.8	-1.4	1.1	-0.2	-0.4	1.4
Alcohol intake versus 10 years previously	0.9	1.3	2.3	1.5	-0.2	-1.4	0.0	-1.5
Father’s age at death	0.4	0.5	1.7	-0.6	0.3	-0.3	-1.3	0.6
Worrier / anxious feelings	2.0	3.7	5.2	1.5	-2.3	1.9	2.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	17.3	0.1	-4.2	-0.3	0.3	-0.1
Falls in the last year	0.5	0.7	3.1	0.5	1.8	0.2	-0.1	-0.5
Hair/balding pattern: Pattern 3	0.4	0.5	0.8	-0.5	0.9	0.8	0.8	0.5
Number of live births	0.0	0.1	0.1	-0.1	0.3	0.3	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.4	-1.4	1.6	-0.9	-1.0	1.4
Pulse rate	1.3	2.1	9.5	-0.2	-3.1	0.5	0.9	0.2
Happiness	4.0	4.8	9.2	2.3	-0.1	2.0	3.0	-2.3
Noisy workplace	1.2	1.5	1.9	1.4	-1.4	0.6	1.1	-1.4
Qualifications: A levels/AS levels or equivalent	2.3	5.1	10.6	-2.6	3.3	-0.4	-1.1	2.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	-0.4	0.2	-0.7	0.2	0.4
Mouth/teeth dental problems: Dentures	1.8	3.0	3.7	1.5	-1.9	1.9	1.9	-1.5
Asthma	0.1	0.2	0.7	0.0	0.1	-0.3	-0.8	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	0.0	-0.4	0.8	0.9	-0.0
Medication: Cholesterol lowering	0.8	1.3	3.1	-1.1	-1.8	-0.5	-0.6	1.1
Depression (self-reported)	1.5	1.8	3.9	-0.2	1.6	2.0	1.5	0.2
Medication: Lansoprazole	2.2	2.5	10.7	0.9	-3.3	-0.1	0.2	-0.9
Prospective memory result	1.5	1.8	3.0	1.2	-0.7	1.7	1.7	-1.2
Lung cancer (father)	0.4	0.5	1.0	1.0	-0.1	0.4	0.4	-1.0
Illnesses of mother	0.3	0.4	1.2	0.6	1.1	-0.3	-0.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.9	-1.6	2.0	-0.6	-0.8	1.6
Pulse wave Arterial Stiffness index	1.1	1.2	2.1	1.1	-0.6	1.5	1.0	-1.1
Impedance of arm (left)	0.9	3.9	11.1	0.4	0.4	3.3	2.8	-0.4
Arm fat mass (right)	0.5	1.9	2.4	1.6	-1.1	1.5	1.1	-1.6
Trunk predicted mass	0.1	0.5	0.8	-0.6	0.9	-0.0	-0.8	0.6
Standing height	0.4	3.7	9.9	-0.1	2.4	3.1	1.7	0.1
Length of working week for main job	0.1	0.2	0.4	-0.3	0.6	-0.2	-0.3	0.3
Exposure to tobacco smoke at home	1.1	1.3	3.4	-0.6	0.2	1.8	1.4	0.6
Breastfed as a baby	0.7	0.9	1.2	-1.1	-1.0	-0.5	-0.8	1.1
Tense / ‘highly strung’	0.4	0.7	1.4	0.5	-1.2	0.6	1.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	5.0	0.2	-2.2	0.3	0.4	-0.2
Hair/balding pattern: Pattern 4	2.7	6.5	14.6	-3.8	0.6	0.0	-1.7	3.8
Birth weight of first child	1.0	1.9	4.0	-0.6	-1.2	-1.8	-2.0	0.6
Peak expiratory flow (PEF)	0.8	1.9	2.6	-1.5	-0.2	-1.4	-1.6	1.5
Pulse wave reflection index	0.7	0.9	1.3	1.2	1.1	0.6	0.3	-1.2
Ever highly irritable/argumentative for 2 days	1.9	2.3	3.2	1.6	-1.2	1.3	1.8	-1.6
Loud music exposure frequency	0.2	0.2	0.3	-0.6	-0.1	-0.2	-0.3	0.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.7	-1.9	1.3	-0.8	-1.4	1.9
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	2.6	1.6	0.4	0.8	1.5	-1.6
Blood clot in the leg (DVT)	0.4	0.5	1.2	-0.7	-1.1	0.4	-0.3	0.7
Medication: Paracetamol	1.5	2.5	10.4	-0.4	-3.2	-1.3	-0.2	0.4
Headache pain in last month	2.6	4.4	15.8	-0.8	-4.0	-2.1	-0.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.8	0.1	1.4	-0.3	-0.0	-0.1
Glaucoma (self-reported)	0.2	0.3	0.5	-0.4	0.6	-0.7	-0.3	0.4
Gout (self-reported)	0.1	0.2	0.8	0.3	0.9	0.2	-0.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.4	-1.2	-1.5	-1.4	-1.4	1.2
Medication: Amlodipine	0.7	1.0	4.4	-0.0	2.1	0.7	0.2	0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.1	0.5	1.0	0.9	0.7	-0.5
Birth weight	1.1	2.3	3.2	-1.8	1.4	-1.0	-1.5	1.8
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.5	-1.6	0.5	-0.7	-1.0	1.6
High blood pressure (siblings)	1.4	2.0	5.9	0.3	0.2	2.4	2.0	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.4	4.7	-1.0	2.2	-0.2	-0.6	1.0
Body fat percentage	0.8	3.0	6.3	1.5	-2.5	1.7	1.2	-1.5
Leg fat percentage (right)	0.7	2.6	10.9	1.0	-3.3	0.3	0.1	-1.0
Arm fat-free mass (right)	0.2	0.9	2.2	-0.8	0.6	-0.8	-1.5	0.8
Exposure to tobacco smoke outside home	0.6	0.8	1.7	-1.3	-0.1	-0.4	-0.7	1.3
Comparative body size at age 10	0.8	2.1	7.9	-1.1	2.8	-0.0	-0.5	1.1
Number of full brothers	0.5	0.7	1.6	0.7	-1.3	-0.8	-0.4	-0.7
Worry too long after embarrassment	0.1	0.2	0.9	-0.1	-0.9	0.2	-0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.4	1.6	-1.3	0.2	1.2	-1.6
Wheeze or whistling in the chest in last year	1.3	2.4	5.3	-1.1	-0.6	-2.3	-1.9	1.1
Number of children fathered	0.4	0.5	1.2	-0.4	-1.1	0.9	0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	4.5	-0.6	2.1	-0.5	-0.8	0.6
Age at first live birth	0.5	0.9	3.8	-0.0	2.0	-0.8	-0.5	0.0
Pulse wave peak to peak time	1.3	1.6	2.4	-1.3	0.8	-1.6	-1.2	1.3
Health satisfaction	1.8	2.3	3.3	1.8	-0.9	1.0	1.8	-1.8
Shortness of breath walking on level ground	1.2	1.4	2.5	-0.9	-1.5	-1.6	-0.9	0.9
Qualifications: College or University degree	2.4	7.4	21.2	-2.7	4.6	-0.1	-1.1	2.7
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.1	0.7	0.8	0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.1	1.2	-0.0	0.5	1.5	-1.2
Emphysema/chronic bronchitis	0.5	0.5	1.3	0.2	-0.4	-1.1	-1.1	-0.2
Medication for pain relief, constipation, heartburn	1.1	1.9	7.8	0.1	2.8	1.2	0.4	-0.1
Neck or shoulder pain in last month	4.5	6.4	12.0	-1.0	-3.3	-3.5	-2.6	1.0
Medication: Blood pressure	0.2	0.3	0.6	0.5	-0.8	0.2	0.3	-0.5
Angina (self-reported)	0.2	0.3	0.8	-0.4	0.6	-0.3	-0.9	0.4
Migraine (self-reported)	0.2	0.3	0.6	-0.5	-0.2	0.5	0.8	0.5
Medication: Ibuprofen	0.3	0.4	0.9	-0.2	-1.0	0.5	0.8	0.2
Medication: Allopurinol	0.4	0.5	1.1	-0.3	-0.1	-1.1	-1.0	0.3
Medication: Omeprazole	2.6	3.1	6.0	-2.5	-0.4	-1.1	-1.5	2.5
Medication: Seretide 50 evohaler	2.2	2.5	3.1	1.7	1.1	1.8	1.6	-1.7
Mean time to correctly identify matches	2.6	4.9	7.5	2.7	1.4	1.8	2.1	-2.7
Heart disease (mother)	0.9	1.1	1.8	-1.2	1.4	0.6	-0.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.3	-0.5	-1.5	-0.8	-0.6	0.5
Whole body fat mass	0.4	1.8	2.7	1.2	-1.7	1.6	0.9	-1.2
Leg fat mass (right)	0.3	1.1	4.0	0.9	-2.0	0.3	-0.2	-0.9
Arm predicted mass (right)	0.1	0.7	1.7	-0.7	0.3	-0.6	-1.3	0.7
Pulse rate, automated reading	0.7	2.3	4.5	-2.1	-1.3	-0.7	-0.6	2.1
Alcohol intake frequency.	0.9	2.1	3.9	-0.9	-2.0	-1.6	-1.7	0.9
Comparative height size at age 10	0.4	2.2	5.1	0.4	2.3	2.1	1.2	-0.4
Number of full sisters	0.6	0.7	2.3	0.6	-0.3	-1.5	-0.7	-0.6
Suffer from ‘nerves’	1.4	2.1	3.1	1.5	-1.7	0.5	1.8	-1.5
Overall health rating	0.6	1.3	6.3	0.0	-2.5	0.1	0.1	-0.0
Chest pain or discomfort	0.5	0.7	1.8	0.8	-1.4	0.6	0.4	-0.8
Had major operations	0.2	0.3	0.6	0.2	0.4	0.8	0.7	-0.2
Age at last live birth	0.6	0.8	1.3	-0.7	1.1	-1.0	-1.0	0.7
Family relationship satisfaction	2.9	3.5	5.4	2.3	-0.1	1.6	2.0	-2.3
Leg pain on walking	0.8	0.9	3.4	0.0	-1.8	0.8	0.9	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.8	1.2	-2.2	-0.2	0.0	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.3	-1.1	-1.1	0.3	-0.7	1.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.5	-1.6	1.3	-0.6	-1.1	1.6
Medication: Aspirin	0.1	0.1	0.3	0.2	-0.5	-0.4	-0.3	-0.2
Supplements: Vitamin C	0.7	0.9	1.4	-0.9	0.1	-1.2	-1.1	0.9
Knee pain experienced in last month	1.0	1.6	4.9	1.0	-2.2	-0.9	-0.6	-1.0
Hypertension (Self-reported)	0.3	0.7	1.3	1.1	-0.6	0.6	0.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.1	1.3	-1.1	1.4	1.3	-1.3
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.7	0.2	-0.3	-0.9	0.7
Illnesses of siblings: Diabetes	0.7	0.9	4.2	-0.1	-2.0	0.2	-0.2	0.1
Smoking status: Previous	2.5	3.7	8.1	2.9	-0.2	0.6	1.3	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.4	0.1	0.2	2.1	1.3	-0.1
Whole body fat-free mass	0.1	0.3	1.1	-0.1	1.0	0.3	-0.5	0.1
Leg fat-free mass (right)	0.1	0.6	2.4	0.1	1.5	0.9	-0.1	-0.1
Arm fat percentage (left)	0.5	2.0	2.7	1.5	-1.7	1.4	1.0	-1.5
Average weekly red wine intake	0.2	0.3	1.6	0.0	1.3	-0.2	-0.1	-0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	-1.0	0.3	0.2	-0.5	1.0
Mood swings	1.3	2.4	5.3	1.5	-2.3	0.9	1.2	-1.5
Loneliness, isolation	0.5	0.7	1.5	0.7	-1.2	0.3	0.9	-0.7
Long-standing illness, disability or infirmity	0.5	0.8	3.1	-0.5	-1.8	-0.2	-0.4	0.5
Ever had bowel cancer screening	1.3	1.5	3.6	0.7	-0.6	1.9	1.6	-0.7
Diabetes diagnosed by doctor	0.2	0.4	0.7	0.5	-0.9	0.2	0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.2
Friendships satisfaction	0.9	1.1	2.3	1.5	-0.3	0.1	0.9	-1.5
Qualifications: nursing, teaching	6.0	9.4	15.8	-4.0	3.2	-1.0	-2.1	4.0
Commuting to job workplace: Walk	0.7	0.8	1.1	1.1	0.9	-0.2	0.8	-1.1
Eye problems/disorders: Cataract	0.7	0.8	1.2	1.0	0.9	-1.1	-0.4	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.0	1.6	-0.3	0.1	1.7	-1.6
Medication for cholesterol	0.1	0.2	0.5	-0.4	0.7	0.0	-0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	3.1	-1.8	-0.8	-1.3	-1.8	1.8
Back pain experienced in last month	1.0	1.4	5.8	0.8	-2.4	0.0	0.1	-0.8
Mineral and other dietary supplements	0.7	1.0	4.5	0.3	-2.1	-0.0	0.3	-0.3
Breast cancer (self-reported)	1.5	1.8	2.7	1.4	-1.7	0.6	1.3	-1.4
Asthma (self-reported)	0.1	0.1	0.4	0.2	-0.3	-0.0	-0.6	-0.2
Osteoporosis (self-reported)	1.4	1.7	5.0	0.9	2.2	1.3	0.6	-0.9
Osteoarthritis (self-reported)	0.6	0.8	1.1	1.1	-0.9	0.7	0.8	-1.1
Medication: Aspirin	0.0	0.0	0.1	0.1	0.1	-0.2	-0.4	-0.1
Medication: Gliclazide	0.8	0.9	1.7	0.8	0.5	1.1	1.3	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.4	0.9	0.7	0.7	0.4
Smoking status: Current	0.5	0.7	2.7	-0.7	-1.6	-0.0	-0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	6.0	-2.4	-0.2	-0.8	-1.3	2.4
Whole body water mass	0.1	0.3	1.1	-0.1	1.1	0.2	-0.5	0.1
Leg predicted mass (right)	0.1	0.8	2.9	0.1	1.7	1.0	-0.0	-0.1
Arm fat mass (left)	0.3	1.3	1.8	1.2	-1.3	1.1	0.6	-1.2
Number of self-reported non-cancer illnesses	0.6	1.1	4.9	0.0	-2.2	0.7	-0.1	-0.0
Average weekly champagne plus white wine intake	1.3	1.9	6.7	-0.8	2.6	-0.7	-0.8	0.8
Miserableness	0.8	1.4	6.1	0.4	-2.5	-0.6	0.3	-0.4
Guilty feelings	0.5	0.7	1.2	1.0	-1.1	-0.3	0.6	-1.0
Wears glasses or contact lenses	0.4	0.5	1.3	-0.0	0.4	1.1	0.9	0.0
Ever taken oral contraceptive pill	0.6	0.7	1.6	-1.2	0.3	-0.1	-0.4	1.2
Hearing aid user	0.3	0.4	0.8	-0.9	0.2	0.1	-0.6	0.9
Mother’s age at death	0.3	0.4	0.6	0.8	-0.8	0.1	-0.2	-0.8
Financial situation satisfaction	1.3	1.7	5.0	1.0	-2.2	0.3	1.2	-1.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	-0.1	-0.8	-0.4	-0.8	0.1
Commuting to job workplace: Public transport	1.7	2.0	9.0	0.6	3.0	0.3	0.3	-0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.3	-0.6	-0.3	-0.6	-0.6	0.6
Medication: Blood pressure	0.3	0.6	1.2	0.3	-1.0	1.1	0.9	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.1	-0.4	-1.4	0.6	0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.5	0.1	1.9	-0.7	-0.7	-0.1
High cholesterol (Self-reported)	0.3	0.6	1.0	1.0	-0.7	0.0	0.8	-1.0
Medication: Bendroflumethiazide	0.5	0.7	1.5	0.2	-1.2	1.2	0.7	-0.2
Medication: Paracetamol	1.5	2.3	8.8	-0.4	-3.0	-1.5	-0.3	0.4
Medication: Lisinopril	0.2	0.2	0.4	-0.7	-0.2	0.2	-0.2	0.7
Medication: Atorvastatin	1.1	1.4	2.3	-1.4	-0.2	-0.9	-1.5	1.4
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.8	0.1	0.1	0.1	0.8
Alcohol drinker status: Never	0.3	0.3	0.8	-0.9	0.4	-0.0	-0.3	0.9
Ever smoked	0.4	0.7	1.2	1.1	-0.6	0.5	0.7	-1.1
Basal metabolic rate	0.0	0.2	0.5	0.2	0.7	0.5	-0.2	-0.2
Leg fat percentage (left)	0.6	2.4	10.9	0.6	-3.3	0.4	-0.0	-0.6
Arm fat-free mass (left)	0.0	0.1	0.6	-0.1	0.0	-0.2	-0.8	0.1
Number of operations (self-reported)	0.1	0.2	0.5	-0.2	-0.6	-0.4	-0.7	0.2
Average weekly beer plus cider intake	0.7	1.0	3.9	0.8	-2.0	-0.1	-0.1	-0.8
Irritability	0.1	0.2	1.0	0.2	-1.0	-0.0	0.4	-0.2
Risk taking	0.1	0.1	0.6	0.0	0.8	0.1	-0.4	-0.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	-1.4	0.7	0.2	-0.7	1.4
Fractured/broken bones in last 5 years	1.9	2.4	3.2	1.8	1.1	1.5	1.4	-1.8
Age started oral contraceptive pill	2.5	3.2	4.5	-1.7	1.5	-1.9	-2.1	1.7
Diastolic blood pressure, automated reading	3.3	10.2	12.9	3.5	-2.5	2.7	3.6	-3.5
Ever depressed for a whole week	0.3	0.3	0.7	-0.0	-0.7	0.6	0.9	0.0
Unable to work because of sickness or disability	0.8	1.0	1.7	-1.3	-0.1	-0.9	-0.8	1.3
Commuting to job workplace: Cycle	1.1	1.3	2.0	1.4	1.4	-0.7	0.4	-1.4
Myopia	1.0	1.5	3.5	0.8	-0.1	1.6	1.9	-0.8
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.9	-0.5	1.4	-0.5	-0.3	0.5
Cholesterol lowering medication	0.7	1.0	1.5	1.2	1.1	0.6	0.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.8	-1.7	-1.1	0.2	-0.2	1.7
Pain experienced in last month	2.3	3.8	11.4	0.2	3.4	2.5	1.1	-0.2
Supplements: Calcium	0.5	0.5	1.1	-1.1	0.0	-0.2	-0.4	1.1
Basal cell carcinoma (self-reported)	0.7	0.9	2.5	0.0	-1.0	-1.6	-0.9	-0.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.3	-0.0	-1.8	0.8	0.6	0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	-0.5	-0.7	0.9	-0.0	0.5
Heart disease (siblings)	0.8	1.0	2.0	-0.9	-0.7	-0.9	-1.4	0.9
Alcohol drinker status: Previous	0.9	1.0	1.4	-1.2	0.8	-0.4	-1.1	1.2
Pack years of smoking	0.3	0.4	1.3	0.6	0.4	0.4	1.1	-0.6
Impedance of whole body	0.6	3.1	7.4	0.1	-1.3	2.7	2.5	-0.1
Leg fat mass (left)	0.2	1.0	3.7	0.7	-1.9	0.5	-0.2	-0.7
Arm predicted mass (left)	0.0	0.1	0.6	-0.1	0.2	-0.3	-0.8	0.1