Hub : Genes

KIAA0319

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2070	0.0530	7.3e-06	0.005	0.067	0.027	0.067	0.013	0.06800	1.5e-08	2.5e-04	1.3e-08	9.7e-03
2	NTR	Blood	0.0328	0.0110	4.1e-04	0.010	0.013	0.005	0.013	0.008	0.00022	3.6e-05	5.7e-03	2.8e-05	9.8e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.1127	0.0372	2.9e-04	0.029	0.018	0.041	0.040	0.042	0.00011	2.2e-03	5.3e-06	5.6e-06	4.0e-06
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0730	0.0360	8.7e-03	0.020	0.006	0.018	NA	0.014	0.02400	1.4e-01	3.3e-02	NA	4.8e-02
5	TCGA	Prostate Adenocarcinoma	0.0782	0.0371	7.0e-04	0.013	0.010	0.010	NA	0.006	0.01400	2.5e-02	3.0e-02	NA	7.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	3.5	-0.6	0.7	-0.2	0.5	-1.9
Bipolar Disorder or Schizophrenia	2.8	6.9	28.1	-0.1	0.7	-0.5	-2.4	-5.3
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.0	1.1	-0.3	0.1	-0.9
Depression (Nagel 2018)	0.3	0.4	1.1	-0.5	-0.2	0.7	0.5	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.7	5.2	-0.9	0.5	-0.0	2.3	1.5
Neuroticism (Nagel 2018)	0.7	1.6	4.5	1.2	-0.0	1.0	-1.1	-2.1
Schizophrenia (2018)	5.5	11.5	44.2	1.0	0.5	-0.5	-3.4	-6.7
Schizophrenia vs Biploar Disorder	3.6	4.7	15.7	-0.0	-1.6	-2.2	-4.0	-0.8
Worry (Nagel 2018)	0.3	0.6	2.3	0.5	-0.3	1.5	-0.5	-0.4
Alzheimer’s Disease (in mother)	0.7	0.8	3.1	0.4	0.6	1.8	0.6	-0.4
Alzheimer’s Disease (in father)	1.2	1.3	3.0	-1.1	1.2	-0.6	0.7	1.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.3	0.8	0.9	0.2	0.6
Crohns Disease (2017)	1.4	3.0	6.4	1.4	1.1	1.5	1.8	-2.5
Irritable Bowel Disease (IBD)	1.1	2.6	7.2	1.3	1.0	1.2	1.4	-2.7
Ulcerative Colitis (UC)	0.3	0.7	1.8	0.8	0.3	0.6	0.5	-1.3
Major Depression (MDD)	1.0	1.3	3.4	1.4	0.1	0.5	-0.8	-1.8
Reaction Time	0.6	1.1	1.8	-1.1	1.4	0.9	0.5	-1.0
Verbal and Numeric Reasoning (VNR)	1.6	3.9	11.2	-1.0	0.1	-1.4	2.3	3.3
Breast Cancer	0.6	1.4	2.6	-1.2	1.0	0.0	1.5	1.6
Ovarian Cancer	2.0	2.7	7.7	-0.1	1.4	1.9	0.1	-2.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.2	1.7	3.6	-1.2	1.9	-1.6	0.7	0.7
Bipolar Disorder (2011)	0.8	0.7	2.9	-0.2	0.9	-0.1	0.0	-1.7
Body Mass Index (BMI) (2010)	0.4	0.5	1.1	0.7	-0.7	0.0	-0.7	-1.0
Coronary Artery Disease (CAD)	0.4	0.5	1.7	0.5	0.2	0.5	1.3	0.2
Crohns Disease (2012)	1.7	2.8	5.0	0.2	0.5	2.2	2.1	-2.0
Mean Putamen Volume	0.3	0.4	1.3	-1.1	0.2	0.0	0.1	-0.8
Fasting Glucose	0.7	0.8	2.7	-0.5	-0.8	-0.3	-0.7	1.6
HbA1C	2.9	3.3	9.9	1.5	-0.6	-0.2	-1.9	-3.1
HDL Cholesterol	1.3	2.1	3.9	-2.0	-0.6	-1.4	-1.4	1.5
LDL Cholesterol	0.7	1.1	2.5	-0.4	1.5	0.8	1.6	-0.1
Lupus	0.6	1.0	3.2	-0.6	-0.7	-0.4	-0.6	1.8
Neuroticism (2016)	2.1	3.0	8.6	2.1	-0.0	1.2	0.6	-2.9
Primary Biliary Cirrhosis	0.8	1.1	3.7	0.6	0.8	-0.8	-0.7	-1.9
Rheumatoid Arthritis	0.5	0.8	1.5	0.8	-1.0	0.5	0.6	1.2
Schizophrenia (2014)	5.9	13.1	47.9	1.6	0.3	-0.8	-3.8	-6.9
Triglycerides	1.2	1.9	4.7	0.7	1.5	1.4	0.6	-2.2
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.1	1.8	-0.5	1.3	-0.3	-1.3
Ulcerative Colitis	1.1	1.6	6.5	0.6	0.6	0.7	0.4	-2.5
Blood Eosinophil Count	0.2	1.8	2.5	1.5	-1.6	1.4	1.5	-0.0
Blood Platelet Count	0.6	7.3	27.0	-2.7	-1.1	-0.8	0.4	5.2
Blood Red Count	0.1	0.7	1.7	1.3	0.2	1.1	0.8	-0.1
Blood White Count	0.3	2.5	5.0	2.0	0.8	2.2	1.6	0.1
Heel T-Score	0.3	2.3	4.0	2.0	0.8	2.0	1.6	0.6
BMI	0.6	3.6	6.4	1.7	0.2	2.5	1.6	-2.5
Height	0.2	4.8	8.7	-2.2	3.0	-1.8	1.8	1.9
Waist Hip Ratio (WHR)	0.9	3.9	9.7	1.6	1.9	3.1	1.7	-1.0
Systolic Blood Pressure	0.5	2.5	6.0	1.2	-2.4	-0.4	-2.2	-0.3
Smoking Status	0.5	1.2	3.8	1.0	1.9	0.9	0.6	-0.1
Allergy or Eczema	0.1	0.2	1.0	-1.0	0.1	-0.3	-0.1	0.4
Cardiovascular Disease	0.4	1.2	2.8	0.8	-0.3	0.9	-1.2	-1.7
Hypothyroidism (self reported)	1.7	4.0	9.8	1.3	1.2	3.1	2.0	-1.7
Respiratory disease	0.0	0.1	0.1	0.1	0.2	0.3	0.2	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	0.8	1.1	0.1	0.5	-0.2
Lung FEV1/FVC ratio	0.5	2.3	4.1	-2.0	-0.5	1.1	1.5	1.9
Lung FVC	0.7	3.5	7.3	-0.3	-2.3	-2.0	-2.7	0.8
Neuroticism	0.6	1.4	2.5	1.1	1.3	1.1	-0.7	-1.6
Chronotype (morning person)	0.6	1.3	6.0	-0.1	0.4	-0.1	-0.6	-2.4
Hair Pigment	0.0	0.4	1.0	-0.2	0.3	1.0	-0.5	-0.6
Tanning	0.1	1.4	5.3	2.3	0.7	-0.2	-0.6	-0.8
Hand grip strength (left)	1.0	2.7	6.9	0.1	2.6	0.5	2.6	-0.2
Number of treatments/medications taken	1.0	1.7	2.5	1.4	-1.4	-0.1	-1.6	-1.5
Average weekly spirits intake	1.8	2.2	6.3	-0.6	0.2	2.5	1.9	0.7
Sensitivity / hurt feelings	0.5	0.9	1.8	1.3	0.1	0.8	-0.4	-1.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.5	-0.5	0.4	0.8	1.2	-0.8
Hearing difficulty/problems: Yes	0.4	0.7	1.8	0.6	0.6	0.8	0.4	-1.4
Relative age of first facial hair	0.7	1.5	2.9	-0.4	1.2	-1.4	-0.9	1.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	0.3	-0.9	0.2	1.1	0.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	5.5	-1.1	-1.0	-0.7	-0.5	2.3
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	-0.4	-0.3	-0.6	-0.5	1.6
Systolic blood pressure, automated reading	0.7	2.1	4.7	1.8	-2.2	0.9	-1.3	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	0.4	-0.0	1.1	0.4	-0.4
Angina	0.3	0.4	1.1	1.1	0.3	-0.5	0.5	0.4
Medication for hormone replacement therapy	0.6	0.6	2.0	-0.8	-1.4	0.0	-0.7	0.3
Vitamin and mineral supplements	1.5	2.0	5.1	-1.3	0.7	1.3	1.0	2.3
Supplements: Zinc	1.1	1.2	3.2	1.7	0.3	0.1	0.2	-1.8
Medication: Co-codamol	0.8	0.9	1.5	1.2	0.9	1.0	-0.7	-1.0
Medication: Metformin	0.5	0.7	1.6	0.4	1.3	1.0	0.8	-0.2
Diabetes (father)	0.9	1.1	2.8	-0.5	0.0	1.1	1.0	-1.7
Diabetes (mother)	0.9	1.2	4.2	0.8	0.3	1.0	-0.2	-2.1
Severe depression (siblings)	2.0	2.3	6.8	-0.2	1.5	1.5	0.1	-2.6
Pack years adult smoking proportion	0.6	0.9	2.8	0.5	-0.1	1.7	0.7	-0.9
Impedance of leg (right)	0.5	2.3	4.4	-1.6	2.1	-0.3	0.6	2.1
Leg fat-free mass (left)	0.1	0.5	1.9	0.1	0.8	-0.0	1.4	0.4
Trunk fat percentage	0.6	2.5	6.1	-0.4	-0.1	1.6	2.5	1.9
Hand grip strength (right)	0.8	2.1	6.1	0.8	1.1	1.4	2.5	-0.7
Townsend deprivation index at recruitment	1.0	1.4	2.3	1.3	1.5	0.9	-0.5	-1.5
Current tobacco smoking	0.9	1.4	4.9	-0.9	2.2	0.9	0.6	0.6
Average weekly fortified wine intake	0.7	0.8	2.4	-1.5	-0.9	-0.4	-0.4	0.8
Maternal smoking around birth	0.3	0.4	1.9	-0.1	0.2	0.0	0.1	1.4
Fed-up feelings	0.1	0.1	0.6	0.3	0.2	-0.7	-0.2	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.1	0.1	0.7	0.7	1.4	-1.2
Relative age voice broke	0.3	0.5	1.4	0.1	0.8	-0.5	-0.5	1.2
Taking other prescription medications	0.4	0.5	2.2	0.6	0.1	1.5	0.1	-0.4
Age when periods started (menarche)	0.3	0.7	2.7	0.3	-0.7	-0.2	-1.6	0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.6	-0.6	-0.2	0.2	0.6	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	9.2	-0.2	-0.0	-0.4	0.2	3.0
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.4	1.0	1.2	0.7	0.9	-1.1
Qualifications: CSEs or equivalent	1.0	1.3	2.5	0.3	1.6	0.9	1.2	-1.2
Serious illness, injury or assault to yourself	0.2	0.3	0.7	-0.0	0.5	-0.8	-0.3	0.7
High blood pressure	0.7	2.1	3.7	1.8	-0.8	0.7	-1.6	-1.9
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	-0.9	0.2	0.2	0.9	1.1
Multivitamins +/- minerals	0.8	1.0	3.8	-0.0	0.4	-0.9	-0.2	-2.0
Stomach or abdominal pain in last month	0.8	1.0	1.9	1.2	-1.0	1.4	0.8	-0.1
Supplements: Glucosamine	1.1	1.4	2.9	1.7	-0.1	-1.4	-0.9	-1.3
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	8.8	0.8	-3.0	-1.4	-1.8	-0.0
Medication: Atenolol	1.2	1.5	4.3	2.1	0.2	0.9	-0.4	-1.5
Medication: Levothyroxine sodium	1.8	3.0	7.1	0.3	1.7	2.2	2.7	-0.1
Sitting height	0.5	3.3	9.3	-1.3	1.5	-1.1	1.3	3.0
Chronic bronchitis/emphysema (father)	1.3	1.5	3.6	1.4	-1.1	-0.1	-0.7	1.9
High blood pressure (mother)	3.3	4.7	11.7	-0.5	-2.4	-1.4	-3.4	-1.9
Body mass index (BMI)	0.3	1.5	3.2	0.8	-0.3	1.8	1.8	-0.5
Impedance of leg (left)	0.7	3.6	5.5	-2.3	2.3	-0.8	0.9	2.3
Leg predicted mass (left)	0.1	0.6	2.1	0.1	0.8	0.0	1.4	0.4
Trunk fat mass	0.7	2.9	8.3	-0.6	0.7	1.5	2.9	1.7
Waist circumference	0.8	3.0	5.6	0.7	1.7	2.4	2.3	-0.8
Number of incorrect matches in round	0.3	0.5	1.4	-0.8	0.1	0.7	-0.1	-1.2
Past tobacco smoking	1.9	3.4	11.4	-1.5	-1.5	-0.2	1.1	3.4
Alcohol usually taken with meals	1.9	3.0	9.3	-3.0	0.4	-1.3	0.6	1.9
Nervous feelings	0.8	1.5	5.2	0.1	0.8	1.0	-0.6	-2.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.8	-0.1	0.8	0.8	0.6	-1.7
Hearing difficulty/problems with background noise	0.8	1.3	4.0	0.9	1.3	-0.1	0.1	-2.0
Hair/balding pattern: Pattern 2	1.6	2.0	5.0	1.5	-1.6	0.4	0.6	2.2
Had menopause	0.9	1.1	2.9	0.3	-1.4	0.5	-0.4	1.7
Had other major operations	0.4	0.5	1.7	0.0	-0.3	0.1	0.7	1.3
Forced vital capacity (FVC)	0.6	2.4	7.6	-1.2	1.2	-2.8	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	18.2	-0.4	0.3	-0.6	0.2	4.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.0	0.2	1.4	-0.1	0.1	-1.7
Qualifications: None of the above	2.0	4.3	10.0	2.0	-2.6	-0.3	-3.2	-0.9
Financial difficulties in last 2 years	1.0	1.3	2.5	-1.0	1.6	-0.2	-0.7	-1.6
Mouth/teeth dental problems	0.3	0.4	1.7	0.4	0.2	0.4	1.3	0.2
Heart attack	3.6	4.5	11.3	2.3	-0.6	-0.2	-2.3	-3.4
Allergy	0.3	0.7	1.9	0.6	-0.1	0.9	-0.3	-1.4
Pain all over the body in last month	1.1	1.2	1.9	-1.1	1.0	-1.2	-1.4	0.6
Diabetes (self-reported)	0.3	0.4	1.3	1.1	0.6	0.3	0.7	0.3
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.0	-0.6	2.2	0.8	1.7	1.0
Medication: Ramipril	2.4	3.1	6.9	2.3	0.1	1.7	0.6	-2.6
Medication: Simvastatin	1.6	2.3	5.3	2.3	0.1	1.8	-0.1	-1.7
Fluid intelligence score	1.1	2.3	7.8	-0.7	0.4	-1.2	1.3	2.8
Illnesses of siblings	0.9	1.3	4.4	-0.6	2.1	-1.0	-0.3	0.6
Neuroticism score	1.1	2.4	6.0	0.3	2.2	0.9	0.2	-2.5
Weight	0.3	1.7	5.2	-0.3	1.4	0.7	2.3	0.8
Impedance of arm (right)	0.4	1.8	3.8	-1.6	-0.3	-1.4	-0.9	2.0
Arm fat percentage (right)	0.4	1.4	3.2	0.4	-1.0	1.8	1.7	0.2
Trunk fat-free mass	0.3	2.0	6.7	-0.5	2.6	-0.2	1.7	-0.3
Hip circumference	0.4	1.8	6.1	0.0	0.8	1.3	2.5	0.7
Time employed in main current job	0.9	1.0	2.2	1.5	1.0	1.2	0.4	-0.5
Alcohol intake versus 10 years previously	0.6	1.0	2.7	-1.2	0.6	-0.2	0.6	1.6
Father’s age at death	0.2	0.2	1.0	0.5	-1.0	0.2	0.1	0.1
Worrier / anxious feelings	1.2	2.2	7.2	0.7	-0.0	2.7	0.5	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.1	-0.3	-0.4	-0.0	0.6
Falls in the last year	0.7	1.0	2.9	-0.1	-0.1	1.2	1.7	0.7
Hair/balding pattern: Pattern 3	0.8	1.1	3.4	0.4	-0.6	-0.4	-1.2	-1.9
Number of live births	0.4	0.5	1.1	1.1	-0.6	-0.7	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	5.8	-2.4	1.1	-2.3	-0.5	1.0
Pulse rate	0.7	1.1	4.0	1.1	0.0	0.6	-0.2	-2.0
Happiness	0.9	1.1	2.7	0.2	1.6	0.9	1.0	-0.9
Noisy workplace	0.7	0.8	1.9	1.4	1.3	-0.4	0.3	0.5
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.7	0.8	1.9	1.4	1.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.3	0.7	-1.1	0.3	-0.5	1.1
Mouth/teeth dental problems: Dentures	1.9	3.1	11.1	-0.5	-2.0	-0.5	0.1	3.3
Asthma	0.6	1.1	2.3	0.7	-0.8	0.4	1.5	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	4.5	-0.3	0.6	-2.1	-0.6	-0.7
Medication: Cholesterol lowering	1.8	2.7	6.6	2.6	-0.4	0.0	-1.1	-2.4
Depression (self-reported)	1.2	1.5	2.9	-1.3	1.7	-0.2	-0.4	-1.6
Medication: Lansoprazole	0.7	0.8	2.3	0.8	0.3	0.9	-0.2	-1.5
Prospective memory result	1.1	1.3	3.3	0.5	1.4	1.8	0.5	-1.0
Lung cancer (father)	0.3	0.4	1.2	-0.4	-0.2	-0.5	-0.4	1.1
Illnesses of mother	0.8	1.0	2.2	1.1	1.2	0.6	1.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	8.7	-1.9	0.9	-3.0	-1.1	0.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	-0.2	1.2	1.1	-0.0	-0.9
Impedance of arm (left)	0.5	2.3	6.2	-1.6	-0.2	-1.5	-0.8	2.5
Arm fat mass (right)	0.4	1.7	5.2	0.3	0.4	1.8	2.3	0.1
Trunk predicted mass	0.3	1.9	6.6	-0.4	2.6	-0.2	1.7	-0.3
Standing height	0.6	6.1	12.5	-2.2	3.5	-2.2	1.3	2.5
Length of working week for main job	2.0	2.2	3.3	-1.3	-0.1	-1.8	-1.8	1.6
Exposure to tobacco smoke at home	0.5	0.6	1.9	-0.6	0.2	-0.7	-0.1	1.4
Breastfed as a baby	0.0	0.1	0.1	-0.1	0.2	0.3	0.1	0.3
Tense / ‘highly strung’	1.3	2.1	3.0	1.0	1.5	1.7	1.7	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	14.6	-0.0	3.3	1.4	1.4	-3.8
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	-0.8	1.0	0.3	0.1	-1.4
Birth weight of first child	0.6	1.1	2.0	-1.3	0.2	-1.4	0.3	1.4
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.4	0.2	0.2	-0.2	0.0
Pulse wave reflection index	0.7	0.9	1.6	-0.9	1.3	-0.4	-1.0	-1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	1.1	-0.6	0.2	-0.4	-1.4
Loud music exposure frequency	0.7	0.8	2.9	1.7	1.0	0.4	0.1	0.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	0.6	1.0	1.3	2.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.6	0.1	1.3	0.8	0.0	-0.9
Blood clot in the leg (DVT)	1.3	1.6	4.8	0.1	0.3	-2.2	-1.8	-0.3
Medication: Paracetamol	0.6	1.1	2.0	1.4	-1.4	0.6	-0.5	-1.0
Headache pain in last month	0.2	0.3	0.7	-0.8	0.3	-0.4	-0.7	0.1
Medication for cholesterol, blood pressure or diabetes	3.1	5.2	12.1	-3.2	0.5	-0.6	1.7	3.5
Glaucoma (self-reported)	1.2	1.4	2.1	1.4	0.8	1.2	0.8	-1.4
Gout (self-reported)	0.7	0.9	3.3	-0.5	0.4	0.1	1.0	1.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.5	0.0	0.9	1.8	1.9	0.3
Medication: Amlodipine	0.5	0.6	1.2	0.7	0.2	-1.1	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	1.6	2.0	4.7	1.4	-0.8	0.5	1.6	2.2
Birth weight	0.4	0.8	2.3	0.7	-0.2	-1.5	0.2	1.0
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.3	-0.7	-0.5	-1.8	-0.3	1.8
High blood pressure (siblings)	0.3	0.4	0.9	-0.2	-0.9	0.2	-0.5	-0.8
Forced vital capacity (FVC), Best measure	0.8	2.9	10.2	-0.9	0.8	-3.2	-1.7	-0.3
Body fat percentage	0.6	2.3	5.9	-0.3	0.0	1.8	2.4	1.4
Leg fat percentage (right)	0.6	2.2	5.8	0.1	0.8	2.1	2.4	0.1
Arm fat-free mass (right)	0.4	1.9	4.8	-0.4	2.2	0.0	2.0	0.3
Exposure to tobacco smoke outside home	1.1	1.5	3.8	-1.3	0.3	-1.4	0.2	1.9
Comparative body size at age 10	0.2	0.5	1.3	-1.1	-1.1	-0.4	0.1	0.4
Number of full brothers	0.7	0.9	2.9	-0.0	-1.7	-0.3	-0.9	0.8
Worry too long after embarrassment	0.3	0.5	1.2	0.3	0.8	1.1	0.7	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	7.4	-0.0	2.7	1.3	1.0	-1.7
Wheeze or whistling in the chest in last year	1.3	2.3	4.9	2.2	0.5	1.5	1.0	-1.7
Number of children fathered	1.5	1.7	3.9	0.8	0.4	1.8	2.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	2.9	-1.7	-0.0	-0.2	1.4	1.1
Age at first live birth	0.2	0.3	1.4	0.1	-0.2	-0.1	0.2	1.2
Pulse wave peak to peak time	0.6	0.7	1.3	0.0	-0.9	-1.1	0.2	1.1
Health satisfaction	0.8	1.1	2.0	1.4	-1.4	-0.8	-0.8	-0.1
Shortness of breath walking on level ground	0.6	0.7	1.5	1.2	-0.7	0.9	0.3	-0.9
Qualifications: College or University degree	0.6	1.8	3.0	1.7	1.3	0.8	1.0	-1.7
Eye problems/disorders: None of the above	0.5	0.6	1.4	0.2	-0.1	1.1	-0.5	-1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.6	1.6	1.6	1.0	0.8	-1.5
Emphysema/chronic bronchitis	1.3	1.5	3.1	1.6	0.7	-0.1	-1.8	-1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	-1.0	0.9	0.2	0.6	1.1
Neck or shoulder pain in last month	0.5	0.7	2.5	-1.6	0.6	-0.5	0.3	0.6
Medication: Blood pressure	2.7	4.8	15.3	2.6	-0.4	0.5	-1.2	-3.9
Angina (self-reported)	0.3	0.4	1.3	1.1	0.1	-0.3	0.8	0.4
Migraine (self-reported)	0.7	0.9	2.7	-0.4	-0.9	0.6	0.7	1.6
Medication: Ibuprofen	0.5	0.5	2.2	-0.3	-0.1	-1.5	-0.4	-0.5
Medication: Allopurinol	0.8	1.1	3.9	-0.8	-0.1	-0.9	0.3	2.0
Medication: Omeprazole	0.4	0.5	1.5	-1.2	0.0	0.8	0.5	-0.0
Medication: Seretide 50 evohaler	0.3	0.4	1.0	-0.4	0.2	0.8	-0.0	1.0
Mean time to correctly identify matches	0.7	1.3	2.1	-0.7	1.3	1.3	0.6	-1.5
Heart disease (mother)	1.2	1.5	2.2	-1.1	-1.4	-1.5	-1.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.1	0.4	-0.1	1.8	-0.2	0.5
Whole body fat mass	0.6	2.5	7.5	-0.1	0.7	1.8	2.7	1.1
Leg fat mass (right)	0.5	2.0	6.1	0.5	0.8	1.8	2.5	0.2
Arm predicted mass (right)	0.4	2.0	5.1	-0.3	2.2	0.3	2.2	-0.0
Pulse rate, automated reading	0.2	0.6	1.3	0.1	1.1	-0.1	0.8	-0.9
Alcohol intake frequency.	0.3	0.6	2.4	0.4	1.5	0.5	0.4	-0.3
Comparative height size at age 10	0.8	4.4	9.0	-2.2	0.9	-3.0	-0.0	2.7
Number of full sisters	1.7	2.1	5.5	-1.0	-0.7	-2.3	-1.8	0.5
Suffer from ‘nerves’	0.6	1.0	1.8	-1.4	1.2	1.2	0.5	-0.4
Overall health rating	0.4	0.9	1.9	1.4	-0.3	1.1	0.6	1.0
Chest pain or discomfort	0.5	0.7	2.4	1.5	-0.5	0.5	0.7	0.2
Had major operations	0.2	0.2	0.5	-0.4	-0.2	0.0	0.7	0.7
Age at last live birth	0.9	1.3	2.9	0.4	-1.0	0.9	1.3	1.7
Family relationship satisfaction	1.1	1.4	3.2	1.1	1.0	0.6	1.0	-1.8
Leg pain on walking	0.7	0.9	2.5	1.6	0.2	0.8	1.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.0	-0.4	-0.2	0.1	0.3	1.4
Commuting to job workplace: Car/motor vehicle	1.7	2.0	5.9	-2.4	-1.0	-0.7	-0.1	1.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	0.2	0.5	0.2	0.8	1.0
Medication: Aspirin	0.7	0.9	1.8	1.2	-0.1	1.3	0.1	-1.1
Supplements: Vitamin C	1.1	1.4	3.6	1.4	0.7	0.7	-0.4	-1.9
Knee pain experienced in last month	0.2	0.3	0.4	0.7	-0.5	0.6	-0.1	0.4
Hypertension (Self-reported)	0.6	1.6	2.9	1.7	-1.0	1.0	-1.1	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.9	0.5	-1.6	0.7	-0.6	-2.0
Illnesses of father: Heart disease	0.7	0.9	2.5	0.8	0.6	1.1	0.1	-1.6
Illnesses of siblings: Diabetes	0.6	0.7	1.7	-0.2	-0.7	1.1	0.0	1.3
Smoking status: Previous	3.4	5.1	16.0	1.9	0.5	-0.9	-2.2	-4.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.2	0.7	1.2	-0.3	1.5	0.1
Whole body fat-free mass	0.2	1.3	3.5	-0.4	1.9	-0.3	1.7	0.1
Leg fat-free mass (right)	0.1	0.5	1.6	-0.3	0.8	-0.5	1.3	0.4
Arm fat percentage (left)	0.3	1.4	2.9	0.3	-0.9	1.7	1.7	0.5
Average weekly red wine intake	0.3	0.5	1.4	-1.2	0.8	-0.0	0.3	-0.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	6.2	-0.1	2.5	0.5	-0.0	-0.4
Mood swings	1.8	3.2	6.3	0.4	2.5	1.5	2.2	-1.6
Loneliness, isolation	2.3	3.2	7.4	-1.9	2.7	0.6	2.1	0.0
Long-standing illness, disability or infirmity	0.4	0.5	1.3	0.7	-0.8	-0.3	-0.4	1.1
Ever had bowel cancer screening	1.3	1.5	2.9	1.7	-0.8	1.4	-0.3	-1.4
Diabetes diagnosed by doctor	0.4	0.6	1.0	1.0	0.4	0.5	1.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.6	-0.5	1.0	1.5	2.4	0.5
Friendships satisfaction	0.3	0.4	0.9	1.0	0.6	-0.2	-0.3	-0.7
Qualifications: nursing, teaching	0.9	1.4	2.7	-0.4	0.5	1.2	1.6	1.6
Commuting to job workplace: Walk	1.6	1.8	5.2	1.5	-2.3	0.7	-0.8	-0.4
Eye problems/disorders: Cataract	1.3	1.5	3.5	-0.6	-0.9	-1.7	-0.1	1.9
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	5.9	1.6	0.0	-0.5	-2.4	-2.3
Medication for cholesterol	0.3	0.4	1.5	-0.0	0.5	0.1	1.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	0.2	-0.7	0.4	-0.9	-1.1
Back pain experienced in last month	0.7	1.0	3.0	-0.0	-0.2	-1.7	-1.1	-0.8
Mineral and other dietary supplements	1.7	2.3	5.2	-2.3	-0.0	1.0	1.2	1.9
Breast cancer (self-reported)	0.7	0.9	2.9	-0.6	-1.7	0.2	-0.2	1.1
Asthma (self-reported)	0.4	0.8	1.8	0.5	-0.6	0.4	1.3	1.3
Osteoporosis (self-reported)	0.8	1.0	1.8	-0.3	1.0	-1.2	-1.4	0.9
Osteoarthritis (self-reported)	1.2	1.6	4.1	0.4	-1.9	-0.3	-0.2	2.0
Medication: Aspirin	0.9	1.2	2.2	1.5	-0.0	1.4	0.3	-1.3
Medication: Gliclazide	0.1	0.2	0.5	-0.2	-0.2	-0.7	-0.0	0.5
Illnesses of father: None of the above (group 1)	1.6	1.9	3.9	-1.9	-0.1	-2.0	-0.9	1.0
Smoking status: Current	1.0	1.7	4.1	-0.8	2.0	0.9	1.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.4	-1.3	-1.2	-2.3	-1.7	-0.5
Whole body water mass	0.2	1.2	3.3	-0.2	1.8	-0.1	1.6	-0.1
Leg predicted mass (right)	0.1	0.5	1.4	-0.3	0.8	-0.5	1.2	0.3
Arm fat mass (left)	0.3	1.4	4.2	0.5	0.4	1.5	2.0	0.0
Number of self-reported non-cancer illnesses	1.6	2.9	7.5	2.1	-0.5	0.8	-1.2	-2.7
Average weekly champagne plus white wine intake	1.1	1.5	3.1	-0.6	1.3	1.3	1.8	0.8
Miserableness	0.2	0.4	1.0	-0.4	0.5	-0.6	0.4	-1.0
Guilty feelings	3.3	5.0	17.7	2.0	0.3	1.4	-1.2	-4.2
Wears glasses or contact lenses	0.1	0.2	0.5	0.4	-0.2	0.7	-0.1	-0.3
Ever taken oral contraceptive pill	0.8	0.9	2.2	-0.9	0.7	-0.7	0.6	1.5
Hearing aid user	1.2	1.4	3.6	0.0	1.9	1.1	1.1	-0.9
Mother’s age at death	0.5	0.6	1.6	-1.1	-1.3	0.1	0.0	0.1
Financial situation satisfaction	1.0	1.3	3.9	-0.1	1.5	-0.3	-0.6	-2.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	-0.3	0.2	-0.4	0.5
Commuting to job workplace: Public transport	1.8	2.2	3.5	1.6	1.2	1.9	1.4	-1.2
Eye problems/disorders: Glaucoma	1.4	1.7	4.9	0.5	2.2	1.2	1.2	-0.6
Medication: Blood pressure	0.2	0.3	1.0	0.4	-1.0	0.3	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.1	0.1	-1.2	0.8	0.6	1.8
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.4	1.8	0.0	-1.8	-2.1	-1.6
High cholesterol (Self-reported)	0.7	1.2	2.7	0.9	-0.6	1.4	-0.3	-1.6
Medication: Bendroflumethiazide	1.4	2.1	3.5	1.7	-1.7	-0.4	-1.9	-1.0
Medication: Paracetamol	0.4	0.6	1.7	0.6	-1.3	-0.0	-0.6	-0.6
Medication: Lisinopril	0.1	0.1	0.4	-0.6	0.1	0.2	0.3	0.0
Medication: Atorvastatin	0.2	0.2	0.7	-0.9	-0.4	-0.4	-0.3	0.0
Illnesses of father: High blood pressure	1.6	1.9	6.1	1.3	0.3	2.5	1.3	-0.2
Alcohol drinker status: Never	1.3	1.6	3.4	0.8	-1.7	-0.3	-1.0	1.8
Ever smoked	2.1	3.6	9.9	0.1	3.2	1.2	0.1	-2.6
Basal metabolic rate	0.3	1.5	3.7	-0.2	1.9	0.1	1.9	0.1
Leg fat percentage (left)	0.6	2.2	6.8	-0.4	0.8	1.8	2.6	0.4
Arm fat-free mass (left)	0.3	1.6	4.3	-0.2	2.1	0.1	1.8	-0.3
Number of operations (self-reported)	0.2	0.4	1.5	-0.4	0.4	0.1	0.0	1.2
Average weekly beer plus cider intake	0.7	1.0	2.2	1.2	0.6	-0.4	-1.5	-1.1
Irritability	2.4	4.1	13.3	1.4	1.7	1.0	-1.2	-3.6
Risk taking	1.8	2.6	6.6	-0.0	2.3	0.5	1.1	-2.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.5	-0.9	-1.1	1.0	0.1	-1.2
Fractured/broken bones in last 5 years	1.3	1.6	2.7	-0.8	-1.5	-1.7	-1.1	1.1
Age started oral contraceptive pill	1.6	2.0	6.9	-0.1	-0.1	1.0	1.4	2.6
Diastolic blood pressure, automated reading	0.3	0.8	2.2	-0.2	0.2	1.1	-0.9	-1.5
Ever depressed for a whole week	1.6	1.9	4.7	1.3	1.5	1.0	0.1	-2.2
Unable to work because of sickness or disability	1.2	1.5	4.6	-1.4	-0.6	-0.7	-0.5	2.1
Commuting to job workplace: Cycle	0.8	1.0	2.8	0.4	0.9	0.7	-0.7	-1.7
Myopia	0.3	0.4	1.2	1.1	-0.3	0.9	0.1	-0.0
Vascular/heart problems diagnosed by doctor	1.4	3.7	6.9	-2.4	1.0	-0.5	2.1	2.6
Cholesterol lowering medication	0.5	0.7	1.9	0.1	-0.5	1.0	0.7	1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.3	-1.5	0.1	0.4	0.1	0.1
Pain experienced in last month	0.6	1.0	1.9	0.9	1.1	1.0	1.4	0.1
Supplements: Calcium	0.7	0.7	2.9	0.2	1.7	-0.3	0.7	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.2	-0.3	-0.4	0.1	0.7	1.1
Heart attack/myocardial infarction (self-reported)	3.2	4.1	10.6	2.2	-0.8	-0.1	-2.1	-3.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.8	-0.1	0.1	-2.4	-1.8	-0.2
Heart disease (siblings)	1.0	1.2	2.3	1.4	-1.5	1.1	0.5	-0.8
Alcohol drinker status: Previous	1.8	2.1	5.1	0.0	0.4	-2.0	-2.2	-1.1
Pack years of smoking	0.5	0.8	2.9	0.5	-0.5	1.7	0.6	-0.4
Impedance of whole body	0.6	2.9	8.0	-2.2	0.8	-1.2	-0.1	2.8
Leg fat mass (left)	0.5	1.9	6.4	0.1	0.9	1.5	2.5	0.4
Arm predicted mass (left)	0.4	2.1	5.1	-0.0	2.3	0.5	2.2	-0.3