Hub : Genes

KIAA0319L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1210	0.0523	3.5e-03	0.004	NA	-0.003	NA	-0.002	0.150	NA	8.2e-01	NA	4.5e-01
2	GTEx	Muscle Skeletal	0.0947	0.0469	6.5e-04	0.009	NA	0.007	NA	0.018	0.042	NA	6.0e-02	NA	6.0e-03
3	GTEx	Thyroid	0.0650	0.0430	6.6e-03	0.002	NA	0.009	NA	-0.003	0.200	NA	5.8e-02	NA	6.2e-01
4	METSIM	Adipose	0.0370	0.0223	4.7e-03	0.015	0.013	0.013	0.012	0.014	0.002	4.0e-03	3.5e-03	4.9e-03	2.7e-03
5	YFS	Blood	0.1707	0.0489	8.9e-12	0.000	0.040	0.051	0.044	0.026	0.240	3.4e-13	2.8e-16	2.2e-14	4.9e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	7.4	11.7	16.1	3.5	2.9	4.0	2.8	3.8
Bipolar Disorder or Schizophrenia	3.4	8.2	18.8	2.3	2.5	2.8	4.3	1.7
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	-0.0	1.3	-0.7	1.1	1.1
Depression (Nagel 2018)	0.3	0.5	1.7	-0.3	1.3	-0.2	0.2	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	1.0	0.9	0.8	-0.1	-0.1
Neuroticism (Nagel 2018)	0.5	1.2	4.5	0.1	2.1	-0.0	1.2	-0.4
Schizophrenia (2018)	1.2	2.6	10.9	0.8	0.9	0.7	3.3	-0.0
Schizophrenia vs Biploar Disorder	1.2	1.6	5.2	-0.5	-1.0	-0.8	-1.0	-2.3
Worry (Nagel 2018)	0.5	1.0	3.0	0.1	1.7	0.8	-0.1	-1.2
Alzheimer’s Disease (in mother)	0.6	0.8	1.6	0.4	1.2	0.3	-0.7	1.3
Alzheimer’s Disease (in father)	1.1	1.2	4.4	0.4	-0.9	0.6	0.4	2.1
Alzheimer’s Disease (including proxy)	0.8	1.2	4.8	0.4	0.6	0.4	-0.4	2.2
Crohns Disease (2017)	0.5	1.2	3.6	0.8	-0.3	1.2	0.4	1.9
Irritable Bowel Disease (IBD)	0.5	1.2	5.6	0.2	-0.4	0.1	0.4	2.4
Ulcerative Colitis (UC)	0.4	0.8	3.0	-0.3	-0.3	-0.9	0.4	1.7
Major Depression (MDD)	0.1	0.2	0.4	-0.3	-0.3	0.2	0.4	0.6
Reaction Time	0.9	1.7	7.3	0.3	-0.7	0.6	2.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.9	0.9	0.3	0.4	-0.5	-0.6
Breast Cancer	0.3	0.7	1.3	-1.1	-0.4	-1.0	0.9	-0.6
Ovarian Cancer	0.9	1.3	3.7	-1.4	-0.1	-1.9	-0.4	0.7
Prostate Cancer	2.5	3.5	13.2	1.2	0.4	0.5	1.6	-3.6
Age at First Birth	0.7	1.0	4.0	0.6	-0.3	0.1	-0.6	-2.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	-0.5	0.7	0.1	0.3	1.1
Coronary Artery Disease (CAD)	1.2	1.5	6.0	-0.5	-1.0	-0.1	0.4	-2.4
Crohns Disease (2012)	0.2	0.3	0.8	0.5	0.4	0.2	0.9	0.3
Mean Putamen Volume	2.6	3.0	8.2	-1.1	0.2	-1.8	1.6	-2.9
Fasting Glucose	0.0	0.0	0.1	-0.1	0.3	-0.2	0.3	0.1
HbA1C	2.7	3.1	6.7	-2.6	-0.8	-2.0	0.7	-1.9
HDL Cholesterol	0.8	1.4	3.5	0.7	0.4	1.0	1.4	-1.9
LDL Cholesterol	0.0	0.1	0.2	-0.2	-0.4	-0.2	-0.0	0.4
Lupus	2.0	3.0	8.5	-1.7	-2.9	-0.8	-0.9	-1.4
Neuroticism (2016)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	1.4	2.0	9.2	-0.7	-0.0	-0.3	-3.0	-0.1
Rheumatoid Arthritis	1.6	2.2	4.2	-1.6	-0.9	-1.6	-0.9	-2.0
Schizophrenia (2014)	1.9	4.2	11.0	1.9	1.6	1.8	3.3	0.0
Triglycerides	0.7	1.2	2.1	-0.3	-0.5	-1.3	1.5	1.3
Type 2 Diabetes (T2D) (2012)	1.6	1.8	5.2	-0.5	-2.3	-1.3	-0.4	-1.3
Ulcerative Colitis	0.7	1.0	2.1	-1.0	-0.6	-1.3	-0.2	1.4
Blood Eosinophil Count	0.1	1.0	4.0	-0.0	0.8	-0.2	2.0	-0.1
Blood Platelet Count	0.2	2.3	9.0	0.8	0.1	0.9	-3.0	1.0
Blood Red Count	0.1	1.1	4.1	0.5	-0.0	-0.3	2.0	-1.1
Blood White Count	0.7	5.3	9.0	-2.9	-2.1	-3.0	-1.5	-1.5
Heel T-Score	0.2	1.6	2.3	-1.1	-1.5	-1.3	1.5	0.8
BMI	0.1	0.5	1.2	0.6	0.9	1.1	0.2	0.5
Height	0.2	4.4	11.4	-1.3	-2.6	-1.4	-0.8	3.4
Waist Hip Ratio (WHR)	1.4	6.1	10.4	-2.1	-3.2	-2.7	-2.8	0.4
Systolic Blood Pressure	0.8	4.0	7.8	-1.1	-2.0	-0.8	-2.5	-2.8
Smoking Status	0.1	0.2	0.4	-0.5	-0.5	0.4	-0.1	0.7
Allergy or Eczema	4.4	11.5	31.5	2.8	2.8	2.8	5.6	1.6
Cardiovascular Disease	1.5	5.1	12.7	-1.9	-1.9	-1.8	-1.5	-3.6
Hypothyroidism (self reported)	0.6	1.5	3.6	-0.4	-0.2	-1.1	-1.5	-1.9
Respiratory disease	0.2	0.4	1.6	0.5	1.3	-0.4	0.3	0.3
Type 2 Diabetes (T2D) (2018)	1.0	1.8	7.2	-0.3	-0.6	-0.4	2.7	1.1
Lung FEV1/FVC ratio	0.4	2.1	3.3	-1.0	-1.6	-1.3	-1.5	-1.8
Lung FVC	0.2	1.1	3.1	0.4	1.1	0.2	0.9	-1.8
Neuroticism	0.3	0.8	1.5	-1.2	0.6	-0.9	-0.1	-1.0
Chronotype (morning person)	0.4	0.9	1.8	0.8	0.8	1.3	0.2	-1.1
Hair Pigment	0.0	0.5	1.8	-1.4	-0.4	0.1	-0.6	-0.5
Tanning	0.3	3.2	5.0	2.0	1.5	2.2	1.9	1.1
Hand grip strength (left)	1.2	3.1	5.6	-2.0	-1.8	-2.4	-0.3	-1.6
Number of treatments/medications taken	0.8	1.5	2.5	-1.0	-0.6	-1.6	-1.1	-1.5
Average weekly spirits intake	0.3	0.3	0.8	-0.3	-0.3	-0.1	0.8	0.9
Sensitivity / hurt feelings	0.7	1.2	2.2	0.6	1.5	1.2	-1.3	0.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.4	-0.1	1.5	0.5	-1.6	0.7
Hearing difficulty/problems: Yes	0.5	0.8	2.1	-1.3	-0.1	-1.5	-0.4	-0.1
Relative age of first facial hair	0.2	0.3	1.4	-0.1	0.3	-0.2	0.4	1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.5	0.8	-0.0	0.6	0.3	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-1.0	-0.4	-1.0	0.3	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.1	0.2	-0.5	0.1	-0.8
Systolic blood pressure, automated reading	0.3	0.9	3.3	0.1	-1.8	0.2	-0.6	-0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.1	0.9	-0.3	-0.8	0.1
Angina	0.3	0.4	0.9	-1.0	-0.0	-0.5	-0.4	0.8
Medication for hormone replacement therapy	0.8	0.9	3.1	0.6	-0.5	1.8	-0.0	0.9
Vitamin and mineral supplements	0.1	0.2	0.4	0.3	-0.5	-0.0	-0.6	0.3
Supplements: Zinc	3.2	3.5	15.2	0.4	-0.9	0.6	0.9	3.9
Medication: Co-codamol	0.6	0.7	2.5	0.3	0.5	-0.1	-0.7	-1.6
Medication: Metformin	0.6	0.8	2.0	-0.5	-0.7	-1.4	0.5	-1.0
Diabetes (father)	0.5	0.6	2.4	0.2	-0.5	-0.6	0.1	-1.6
Diabetes (mother)	0.9	1.2	3.7	-0.6	-1.9	-0.7	-0.5	1.0
Severe depression (siblings)	0.3	0.4	0.9	-0.5	-1.0	-0.4	-0.3	0.5
Pack years adult smoking proportion	1.1	1.7	8.1	0.2	0.6	0.3	-2.9	-0.4
Impedance of leg (right)	0.5	2.6	4.0	1.8	-0.7	2.0	-1.2	2.0
Leg fat-free mass (left)	0.1	0.8	2.2	-1.5	-0.2	-1.1	-0.5	0.4
Trunk fat percentage	0.5	1.9	4.9	1.3	0.0	1.5	-0.9	2.2
Hand grip strength (right)	0.2	0.6	2.0	-0.4	-0.4	-0.4	0.6	-1.4
Townsend deprivation index at recruitment	1.5	2.1	4.2	-1.9	-0.1	-1.3	-2.0	1.1
Current tobacco smoking	0.1	0.2	0.5	0.3	0.1	0.7	-0.3	0.3
Average weekly fortified wine intake	0.2	0.2	0.5	0.2	0.7	0.0	0.6	-0.5
Maternal smoking around birth	0.6	0.8	1.3	0.3	1.1	1.1	-1.2	-0.3
Fed-up feelings	0.2	0.4	1.2	0.4	1.1	0.3	-0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.2	-0.6	1.1	-0.8	-0.4	-0.9
Relative age voice broke	0.4	0.6	1.8	-0.7	1.3	-0.4	-0.1	0.6
Taking other prescription medications	0.5	0.8	1.6	-0.9	-1.1	-1.3	-0.5	0.6
Age when periods started (menarche)	0.9	2.1	7.6	0.2	1.4	0.9	-0.2	2.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.3	-0.4	-0.2	-1.1	-0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.9	-0.2	-0.1	0.2	0.9	-0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.8	-1.3	-1.1	0.1	-0.2	1.0
Qualifications: CSEs or equivalent	0.2	0.3	1.0	0.1	1.0	0.0	-0.2	-0.5
Serious illness, injury or assault to yourself	2.5	3.0	11.4	-0.0	-1.5	0.8	0.8	3.4
High blood pressure	1.3	3.7	7.2	-1.6	-1.7	-1.4	-2.7	-2.0
Hayfever, allergic rhinitis or eczema	4.5	9.7	25.4	2.8	2.4	2.6	5.0	1.6
Multivitamins +/- minerals	0.3	0.4	0.7	-0.8	-0.8	-0.6	0.4	0.0
Stomach or abdominal pain in last month	0.6	0.7	2.3	-0.5	-0.2	-0.3	-1.5	-0.8
Supplements: Glucosamine	0.0	0.1	0.2	-0.2	0.5	0.1	0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.5	0.0	-1.5	-0.1	0.7	1.9
Medication: Atenolol	0.6	0.7	1.8	-0.5	-0.8	-0.8	-0.6	-1.3
Medication: Levothyroxine sodium	0.6	1.1	2.0	-0.6	-0.6	-1.3	-1.4	-1.0
Sitting height	0.3	2.2	4.6	-1.7	-2.1	-0.5	-0.7	1.7
Chronic bronchitis/emphysema (father)	1.0	1.1	3.5	-1.0	0.6	-0.7	0.6	-1.9
High blood pressure (mother)	0.2	0.2	0.7	0.1	-0.1	0.1	0.8	-0.6
Body mass index (BMI)	0.1	0.3	0.5	0.6	0.6	0.7	0.0	0.4
Impedance of leg (left)	0.8	4.1	8.2	2.6	-0.3	2.9	-0.6	2.2
Leg predicted mass (left)	0.1	0.7	2.1	-1.4	-0.2	-1.1	-0.5	0.5
Trunk fat mass	0.3	1.5	5.4	0.6	-0.3	0.9	-0.8	2.3
Waist circumference	0.2	0.9	2.3	0.1	-0.8	0.0	-1.2	1.5
Number of incorrect matches in round	1.1	1.9	5.7	1.2	0.7	2.4	-0.2	1.2
Past tobacco smoking	0.4	0.8	1.2	-0.5	0.7	-1.1	-0.9	-1.1
Alcohol usually taken with meals	0.3	0.5	1.6	0.4	0.5	-0.1	0.6	1.3
Nervous feelings	1.0	1.8	4.3	0.0	1.5	1.0	-2.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	1.9	5.1	0.3	2.0	0.5	-2.2	0.7
Hearing difficulty/problems with background noise	0.7	1.2	2.0	-1.0	1.1	-0.9	-1.4	-0.9
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.4	-0.3	-0.0	-0.6	0.2
Had menopause	0.8	1.0	2.1	0.6	1.5	0.2	0.6	1.4
Had other major operations	0.4	0.4	0.9	0.2	-0.3	-0.9	0.9	0.6
Forced vital capacity (FVC)	0.4	1.7	4.8	-1.3	0.6	-1.0	-0.7	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.1	-0.4	0.5	0.1	-0.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.8	0.2	1.2	-0.4	-2.2	0.1
Qualifications: None of the above	1.3	2.7	6.5	-1.8	1.0	-1.4	-0.9	-2.5
Financial difficulties in last 2 years	0.5	0.6	1.8	-0.0	-0.1	0.8	-1.4	-0.8
Mouth/teeth dental problems	0.2	0.2	0.6	-0.2	-0.8	-0.2	0.7	-0.1
Heart attack	0.6	0.8	1.8	0.8	0.8	1.4	0.6	-0.6
Allergy	2.7	6.3	10.7	-2.9	-2.2	-2.5	-3.3	-0.9
Pain all over the body in last month	0.6	0.6	1.3	-0.0	1.1	-0.8	0.1	-1.1
Diabetes (self-reported)	0.9	1.4	2.7	-1.1	-1.1	-1.6	1.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.5	0.1	0.8	0.3	1.9	1.1
Medication: Ramipril	1.3	1.7	3.8	-0.8	-1.5	-0.9	-2.0	-1.1
Medication: Simvastatin	0.5	0.8	3.4	0.5	-0.2	-0.5	-1.9	-0.1
Fluid intelligence score	0.1	0.2	0.6	0.3	-0.1	-0.4	0.1	-0.8
Illnesses of siblings	0.6	0.9	2.9	0.0	-0.7	-0.3	0.9	-1.7
Neuroticism score	0.4	0.8	1.3	-1.1	0.9	-0.6	-1.0	-0.7
Weight	0.1	0.7	2.6	-0.4	-0.7	-0.1	-0.3	1.6
Impedance of arm (right)	0.7	3.2	5.8	-0.8	-2.1	-0.5	-2.2	2.4
Arm fat percentage (right)	0.2	0.8	2.1	0.3	-0.5	0.5	-1.1	1.4
Trunk fat-free mass	0.2	1.0	2.3	-1.5	-0.8	-1.2	0.2	0.9
Hip circumference	0.1	0.6	1.7	0.7	0.1	0.9	0.1	1.3
Time employed in main current job	1.1	1.3	4.3	0.1	1.2	0.3	-2.1	0.7
Alcohol intake versus 10 years previously	3.9	5.9	10.5	-2.8	-1.4	-3.0	-0.3	-3.2
Father’s age at death	0.2	0.3	1.2	-0.2	-0.3	0.2	-1.1	0.3
Worrier / anxious feelings	0.7	1.3	3.5	-1.1	1.0	-0.1	-1.9	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	-1.5	-0.4	-1.1	-0.3	-0.5
Falls in the last year	1.0	1.4	2.7	0.9	1.6	0.5	0.9	1.6
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	0.8	-0.2	1.0	-0.1	0.2
Number of live births	2.2	3.1	6.1	1.8	2.5	2.2	0.9	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.6	-0.6	0.6	-0.6	-0.6	-1.9
Pulse rate	0.3	0.6	1.9	0.3	-0.5	0.6	-0.4	1.4
Happiness	0.2	0.3	0.5	0.4	0.5	0.4	0.7	0.5
Noisy workplace	0.6	0.7	2.8	0.3	1.7	0.0	0.7	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.9	0.7	-1.7	0.1	-0.3	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.8	-1.8	0.0	-1.9	0.6	0.8
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.6	0.4	0.4	0.3	-0.4
Asthma	0.3	0.5	0.8	0.9	0.7	0.3	0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.3	-0.3	0.5	0.2	1.2	0.1
Medication: Cholesterol lowering	0.5	0.8	2.7	-0.1	-0.1	-0.7	-1.6	-1.1
Depression (self-reported)	0.5	0.6	2.1	0.3	-0.2	-0.4	0.6	-1.5
Medication: Lansoprazole	0.7	0.8	1.6	0.2	-0.7	0.9	-1.1	1.3
Prospective memory result	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.1	-0.6
Lung cancer (father)	0.3	0.4	1.0	-0.4	1.0	-0.8	-0.2	-0.0
Illnesses of mother	0.7	0.8	3.7	-0.1	-0.1	-0.3	-1.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.4	-0.2	0.3	-0.0	-0.6	-1.2
Pulse wave Arterial Stiffness index	1.1	1.3	1.8	-1.4	-1.3	-1.1	-0.7	1.3
Impedance of arm (left)	0.4	1.8	4.6	-0.3	-1.4	0.1	-1.5	2.1
Arm fat mass (right)	0.1	0.5	2.0	-0.1	-0.3	0.1	-0.7	1.4
Trunk predicted mass	0.2	1.0	2.2	-1.5	-0.7	-1.1	0.2	1.0
Standing height	0.5	5.1	8.4	-2.4	-2.9	-1.8	-1.0	2.7
Length of working week for main job	1.0	1.1	5.0	0.3	0.6	0.4	-0.1	2.2
Exposure to tobacco smoke at home	0.7	0.8	2.2	-0.8	-0.2	-0.9	-1.5	-0.2
Breastfed as a baby	0.8	0.9	3.3	-0.7	0.2	-0.8	0.5	1.8
Tense / ‘highly strung’	0.5	0.9	3.4	-0.0	1.8	0.3	0.2	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.3	0.2	0.3	-1.0	0.7
Hair/balding pattern: Pattern 4	1.0	2.4	9.1	0.1	1.6	0.5	0.5	-3.0
Birth weight of first child	1.1	2.0	6.4	0.9	-0.9	0.6	1.1	2.5
Peak expiratory flow (PEF)	0.6	1.5	4.4	-0.9	0.0	-1.4	0.1	-2.1
Pulse wave reflection index	0.3	0.3	1.0	-1.0	0.1	-0.5	-0.7	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.8	1.2	0.3	-0.2	-1.0
Loud music exposure frequency	0.5	0.5	1.0	-0.6	-1.0	-0.5	0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	0.9	-0.3	0.7	0.1	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.7	-0.1	0.5	0.2	-1.3	1.3
Blood clot in the leg (DVT)	1.6	2.0	3.9	-2.0	-0.6	-1.4	-0.4	-2.0
Medication: Paracetamol	1.1	1.8	3.8	-1.7	-1.5	-1.9	-0.1	-0.5
Headache pain in last month	1.1	1.9	3.6	-1.8	-1.3	-1.9	-0.8	0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	0.4	1.1	0.4	1.5	0.5
Glaucoma (self-reported)	0.3	0.4	0.8	-0.5	-0.8	-0.5	0.9	0.2
Gout (self-reported)	0.4	0.6	1.1	1.0	0.4	0.8	1.0	-0.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.9	-1.1	-1.0	-2.0	-2.2	-0.9
Medication: Amlodipine	1.3	1.8	2.9	-1.3	-1.7	-1.4	-1.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.7	-0.3	0.6	-1.3	-0.2	0.2
Birth weight	0.2	0.3	0.7	0.3	-0.0	0.7	0.8	-0.6
Chronic bronchitis/emphysema (mother)	2.5	2.9	7.1	1.7	2.7	1.5	1.3	-0.8
High blood pressure (siblings)	0.5	0.7	1.9	-0.2	1.0	-0.0	-1.4	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	-0.6	0.4	-0.4	-0.9	-1.3
Body fat percentage	0.6	2.2	5.1	1.4	0.1	1.7	-0.9	2.2
Leg fat percentage (right)	0.5	1.7	3.0	1.7	0.3	1.7	-0.2	1.5
Arm fat-free mass (right)	0.0	0.2	0.4	-0.3	0.5	-0.0	0.7	0.6
Exposure to tobacco smoke outside home	3.0	4.0	5.6	-2.4	-2.2	-2.4	-1.3	-1.6
Comparative body size at age 10	0.1	0.4	1.2	-0.2	-0.6	-0.4	0.3	-1.1
Number of full brothers	2.2	2.7	5.7	0.8	1.3	0.9	2.4	2.2
Worry too long after embarrassment	0.4	0.7	1.2	-0.6	0.8	-0.5	-1.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.4	-0.5	0.0	-0.7	0.3	-1.6
Wheeze or whistling in the chest in last year	0.5	0.8	2.6	-0.6	0.4	-1.0	-0.2	1.6
Number of children fathered	0.4	0.5	1.1	0.4	-0.8	0.2	1.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.1	1.5	0.2	1.1	0.2	1.2
Age at first live birth	0.2	0.3	1.4	-0.3	-1.2	0.0	-0.4	-0.3
Pulse wave peak to peak time	0.8	0.9	1.5	1.2	1.1	1.0	0.5	-0.8
Health satisfaction	0.2	0.2	0.3	0.3	0.6	-0.3	-0.6	0.6
Shortness of breath walking on level ground	0.6	0.7	1.7	-1.2	-0.4	-1.3	0.4	0.0
Qualifications: College or University degree	1.1	3.4	6.4	1.0	-1.9	0.5	2.5	2.4
Eye problems/disorders: None of the above	0.9	1.0	2.0	-1.1	-1.4	-0.6	-0.6	-1.1
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.4	1.6	1.8	1.6	-0.0	1.5
Emphysema/chronic bronchitis	1.1	1.2	2.3	0.1	-1.2	1.2	-1.0	1.5
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	0.8	0.6	0.8	-0.7	-0.1
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.1	0.5	0.4	-0.6	0.4
Medication: Blood pressure	1.3	2.2	5.4	-1.2	-1.3	-1.1	-2.3	-1.1
Angina (self-reported)	0.4	0.5	1.4	-0.8	0.0	-0.2	-0.6	1.2
Migraine (self-reported)	1.8	2.2	5.6	-2.0	-0.7	-1.0	-2.4	-0.5
Medication: Ibuprofen	0.3	0.3	0.9	-0.7	0.3	-0.3	0.9	-0.4
Medication: Allopurinol	0.6	0.7	1.4	1.1	-0.5	1.2	-0.2	0.9
Medication: Omeprazole	1.4	1.7	3.9	-1.3	-1.1	-2.0	-1.2	-0.4
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.8	-0.5	-1.1	-0.3	1.3
Mean time to correctly identify matches	0.9	1.7	6.9	-0.2	-1.1	-0.2	2.6	-0.5
Heart disease (mother)	1.7	2.1	7.2	-1.3	0.1	-1.1	2.7	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	-0.4	0.9	-0.7	0.7	-1.1
Whole body fat mass	0.3	1.1	3.6	0.6	-0.2	1.0	-0.9	1.9
Leg fat mass (right)	0.2	0.8	2.1	0.8	0.2	1.0	-0.3	1.4
Arm predicted mass (right)	0.0	0.2	0.4	-0.2	0.6	0.0	0.6	0.3
Pulse rate, automated reading	0.1	0.5	0.9	-0.5	-0.8	-0.4	-0.5	-0.9
Alcohol intake frequency.	1.6	3.7	7.0	-2.4	-0.6	-2.1	-1.0	-2.6
Comparative height size at age 10	0.3	1.4	2.9	-1.2	-1.7	-1.1	0.6	1.2
Number of full sisters	0.2	0.3	0.7	-0.1	0.5	0.3	-0.5	0.8
Suffer from ‘nerves’	0.6	1.0	2.2	-1.2	0.1	-0.3	-1.1	-1.5
Overall health rating	0.2	0.4	0.9	-0.5	-0.8	-1.0	-0.5	0.1
Chest pain or discomfort	1.0	1.5	3.1	-1.6	-0.1	-1.1	-1.8	0.8
Had major operations	2.3	2.7	4.2	-2.0	-1.7	-1.7	1.5	1.2
Age at last live birth	0.4	0.5	1.6	-0.8	-1.3	-0.5	-0.1	-0.2
Family relationship satisfaction	1.7	2.1	7.3	-0.8	-1.3	-0.3	-1.1	2.7
Leg pain on walking	1.2	1.6	3.7	-0.7	0.9	-1.9	-0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.3	1.5	0.7	1.5	-0.2	1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.8	0.0	-0.7	-0.9	-0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	1.4	0.4	0.3	0.2	-0.9
Medication: Aspirin	0.2	0.3	0.7	-0.8	-0.1	-0.2	-0.4	-0.6
Supplements: Vitamin C	0.7	0.8	3.3	-0.3	0.7	-0.5	0.2	-1.8
Knee pain experienced in last month	1.1	1.7	4.7	-0.8	1.0	-1.2	-0.9	-2.2
Hypertension (Self-reported)	1.4	3.8	6.5	-1.6	-2.1	-1.5	-2.5	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.4	0.6	-1.2	1.0	-1.2	-0.7
Illnesses of father: Heart disease	0.5	0.7	1.9	0.9	0.6	0.8	1.4	-0.0
Illnesses of siblings: Diabetes	0.6	0.7	2.0	-0.5	0.2	-1.1	-1.4	0.2
Smoking status: Previous	0.4	0.6	1.0	0.6	-0.7	1.0	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.9	-1.5	-0.8	-1.7	-1.4	-0.9
Whole body fat-free mass	0.1	0.7	1.8	-1.4	-0.4	-0.9	0.0	0.8
Leg fat-free mass (right)	0.1	0.6	1.8	-1.4	-0.1	-0.9	-0.0	0.3
Arm fat percentage (left)	0.2	0.8	2.2	0.5	-0.1	0.8	-0.9	1.5
Average weekly red wine intake	0.6	1.0	2.0	0.5	1.3	-0.2	0.9	1.4
Handedness (chirality/laterality): Left-handed	2.6	3.2	6.6	-2.1	-0.8	-2.6	-2.1	0.1
Mood swings	0.3	0.5	1.1	-0.3	1.0	-0.9	-0.2	-0.6
Loneliness, isolation	0.7	1.0	2.7	-0.6	1.6	-1.1	-0.7	0.5
Long-standing illness, disability or infirmity	0.4	0.7	1.8	-0.7	0.3	-1.4	-0.8	0.6
Ever had bowel cancer screening	0.7	0.8	1.3	-1.0	-1.1	-0.9	0.3	0.8
Diabetes diagnosed by doctor	0.4	0.7	1.5	-0.3	-0.7	-0.9	1.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.7	-0.1	1.0	0.4	0.7
Friendships satisfaction	5.7	7.0	18.5	2.6	-0.1	3.1	0.3	4.3
Qualifications: nursing, teaching	0.9	1.4	4.8	0.6	-0.8	-0.3	1.2	2.2
Commuting to job workplace: Walk	0.7	0.7	2.1	0.3	-0.4	0.8	1.5	0.7
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	-1.0	-0.4	-0.6	-0.7	0.2
Medication for cholesterol	1.0	1.5	6.4	0.3	2.5	-0.3	1.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	8.0	-2.5	-1.2	-2.8	0.5	-0.2
Back pain experienced in last month	0.5	0.7	2.8	-0.4	-0.5	-0.2	-1.7	0.5
Mineral and other dietary supplements	0.5	0.6	1.9	-0.1	-0.8	0.4	-1.4	0.6
Breast cancer (self-reported)	0.4	0.5	1.3	-0.8	-0.2	-1.1	-0.8	0.3
Asthma (self-reported)	0.3	0.5	0.8	0.9	0.7	0.3	0.8	0.9
Osteoporosis (self-reported)	1.5	1.8	6.4	1.1	0.2	0.4	-1.1	2.5
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.1	0.1	0.1	1.1	1.1
Medication: Aspirin	0.2	0.3	0.7	-0.9	-0.2	-0.3	-0.4	-0.6
Medication: Gliclazide	0.2	0.2	0.5	0.3	0.2	-0.6	0.0	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.9	-0.5	-0.8	-0.4	0.5
Smoking status: Current	0.1	0.1	0.5	0.2	0.3	0.7	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	0.2	0.1	0.6	-0.2	-1.4
Whole body water mass	0.1	0.8	2.2	-1.5	-0.4	-1.1	-0.1	0.5
Leg predicted mass (right)	0.1	0.5	1.7	-1.3	-0.1	-0.9	-0.0	0.4
Arm fat mass (left)	0.1	0.4	1.6	-0.1	-0.2	0.2	-0.5	1.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	-0.5	-0.6	-1.1	-0.5	-0.6
Average weekly champagne plus white wine intake	1.4	2.0	5.3	1.3	-0.0	0.9	1.5	2.3
Miserableness	0.3	0.5	1.5	-1.2	-0.0	-0.8	0.5	0.4
Guilty feelings	0.7	1.0	1.5	-1.2	0.6	-1.2	-1.1	-0.9
Wears glasses or contact lenses	1.8	2.1	6.1	-0.2	-2.1	-0.0	-0.3	2.5
Ever taken oral contraceptive pill	0.5	0.6	1.3	0.4	-1.1	-0.0	1.1	0.5
Hearing aid user	0.1	0.1	0.4	0.4	0.1	-0.2	0.6	-0.2
Mother’s age at death	1.0	1.2	2.5	-0.5	-0.7	-0.7	-1.6	1.5
Financial situation satisfaction	1.6	2.0	3.8	-1.9	-0.7	-1.8	-1.2	-1.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.0	-0.7	-1.2	0.4	1.2
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.3	0.6	-0.3	-1.1	-0.8
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.3	0.1	-0.2	0.4	-0.6
Medication: Blood pressure	1.0	2.0	5.7	-0.9	-2.4	-0.6	-1.2	1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.4	-0.3	0.3	-0.9	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.4	-0.1	-0.0	-0.2	1.1	-1.2
High cholesterol (Self-reported)	0.6	1.0	2.3	0.6	-0.7	-0.1	-1.4	-1.5
Medication: Bendroflumethiazide	0.4	0.7	2.5	0.1	-0.8	0.0	-1.6	0.2
Medication: Paracetamol	2.0	3.0	6.2	-2.4	-1.8	-2.5	-0.3	-0.4
Medication: Lisinopril	2.2	2.8	4.9	1.3	1.2	2.2	1.1	2.2
Medication: Atorvastatin	0.8	1.0	2.7	0.1	-0.9	-0.1	1.6	-1.2
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.4	0.1	0.7	-0.2	-0.6
Alcohol drinker status: Never	2.1	2.5	6.0	1.9	1.4	2.4	0.9	-0.4
Ever smoked	0.6	1.1	2.3	0.7	-0.2	1.3	1.5	1.1
Basal metabolic rate	0.1	0.5	1.0	-1.0	-0.4	-0.6	-0.0	1.0
Leg fat percentage (left)	0.7	2.5	4.8	2.2	0.4	2.2	0.1	1.6
Arm fat-free mass (left)	0.0	0.2	0.5	-0.5	-0.1	-0.3	0.1	0.7
Number of operations (self-reported)	0.9	1.3	4.7	-0.5	0.4	-0.8	0.9	2.2
Average weekly beer plus cider intake	1.1	1.5	6.0	0.7	0.2	-0.3	2.5	-1.1
Irritability	1.3	2.1	6.8	0.6	1.6	0.9	2.6	-0.1
Risk taking	1.3	1.8	5.2	1.0	1.0	1.1	0.9	2.3
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.8	-1.4	-0.8	-1.0	-0.7	-0.4
Fractured/broken bones in last 5 years	2.3	2.9	7.3	1.8	1.1	2.7	0.2	1.7
Age started oral contraceptive pill	0.5	0.6	1.1	0.3	0.9	-0.9	-0.4	1.0
Diastolic blood pressure, automated reading	0.4	1.1	3.3	0.5	-0.5	1.1	-0.7	-1.8
Ever depressed for a whole week	0.2	0.3	1.1	-0.3	-0.1	-0.0	-1.0	0.4
Unable to work because of sickness or disability	1.4	1.8	5.8	-1.1	0.8	-1.1	-2.4	-0.6
Commuting to job workplace: Cycle	0.6	0.7	2.5	0.3	1.6	0.4	-0.7	-0.5
Myopia	0.7	1.0	4.2	-0.6	-0.2	-0.3	-0.4	2.0
Vascular/heart problems diagnosed by doctor	1.5	4.1	6.3	1.9	1.8	1.6	2.1	2.5
Cholesterol lowering medication	0.3	0.4	1.9	0.5	-1.4	-0.1	-0.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.3	-1.5	-2.0	-2.1	-0.8	0.2
Pain experienced in last month	0.4	0.7	3.3	0.2	-0.2	0.2	1.8	0.2
Supplements: Calcium	1.9	2.1	3.8	-1.9	-0.6	-1.8	-1.7	-0.2
Basal cell carcinoma (self-reported)	1.5	1.8	3.4	-1.4	-1.7	-1.8	-0.9	0.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.5	0.8	0.8	1.6	0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.3	-1.9	-0.3	-1.4	-0.7	-2.1
Heart disease (siblings)	0.7	0.8	3.7	-0.4	0.1	-0.4	0.3	1.9
Alcohol drinker status: Previous	3.7	4.2	8.3	-2.5	-0.8	-2.9	1.6	-1.8
Pack years of smoking	0.9	1.3	6.4	0.1	0.3	0.3	-2.5	-0.2
Impedance of whole body	0.4	2.0	4.5	1.1	-1.0	1.4	-1.2	2.1
Leg fat mass (left)	0.2	1.0	2.2	1.0	0.4	1.2	-0.2	1.5
Arm predicted mass (left)	0.1	0.4	1.0	-0.7	-0.2	-0.4	0.4	1.0