Hub : Genes

KIAA0355

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0180	0.02100	0.014	0.004	-0.002	0.002	0.001	7.2e-03	1.0e-01	7.8e-01	1.5e-01	2.2e-01
2	GTEx	Muscle Skeletal	0.0997	0.0392	0.00140	0.030	NA	0.033	NA	0.042	6.1e-04	NA	2.9e-04	NA	5.8e-05
3	YFS	Blood	0.1083	0.0205	0.00000	0.093	0.105	0.103	0.113	0.094	6.6e-29	1.5e-32	6.2e-32	4.1e-35	3.3e-29
4	TCGA	Thyroid Carcinoma	0.0640	0.0320	0.00077	-0.001	0.023	0.027	NA	0.012	4.8e-01	2.2e-03	1.2e-03	NA	2.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	3.7	1.9	0.4	1.3	-0.3
Bipolar Disorder or Schizophrenia	1.3	3.2	5.3	1.3	1.6	1.8	-2.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.7	-0.2	0.2	0.3
Depression (Nagel 2018)	0.6	0.9	2.7	1.6	0.2	0.7	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.8	-1.7	1.5	0.7	-0.9
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.1	1.0	0.8	-0.6
Schizophrenia (2018)	1.5	3.0	7.5	0.1	1.7	1.3	-2.7
Schizophrenia vs Biploar Disorder	1.5	2.0	5.4	-2.3	0.2	0.2	-1.6
Worry (Nagel 2018)	1.0	2.0	3.8	-0.9	2.0	0.3	-1.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.4	0.7	-0.2	-0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.7	-0.9	-0.5	0.1	0.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-1.3	0.5	0.0	-0.6
Crohns Disease (2017)	0.6	1.4	5.3	0.4	2.3	0.1	-0.2
Irritable Bowel Disease (IBD)	0.5	1.3	2.2	-0.7	1.5	1.4	-0.7
Ulcerative Colitis (UC)	0.8	1.5	4.2	-0.9	0.2	2.1	-0.9
Major Depression (MDD)	1.9	2.4	3.5	-1.9	1.8	-1.0	-1.4
Reaction Time	0.8	1.5	2.0	-1.2	1.4	-0.8	1.4
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.8	-2.4	1.1	0.6	-1.3
Breast Cancer	0.1	0.2	0.4	-0.4	0.7	0.1	-0.3
Ovarian Cancer	0.5	0.6	1.3	-0.1	1.1	-1.1	0.3
Prostate Cancer	0.1	0.1	0.3	-0.1	0.5	-0.1	0.5
Age at First Birth	0.4	0.6	1.1	1.0	-0.9	0.5	0.7
Bipolar Disorder (2011)	1.4	1.4	2.7	0.7	1.0	1.1	-1.6
Body Mass Index (BMI) (2010)	0.3	0.5	1.2	-0.1	-0.7	0.5	-1.1
Coronary Artery Disease (CAD)	1.0	1.2	2.6	-1.1	1.0	0.0	-1.6
Crohns Disease (2012)	1.5	2.4	8.2	-0.5	2.9	-0.0	-1.0
Mean Putamen Volume	1.4	1.6	2.9	-1.7	1.5	0.2	-1.1
Fasting Glucose	0.1	0.2	0.3	-0.4	-0.5	-0.5	0.1
HbA1C	0.1	0.1	0.1	0.2	-0.1	-0.3	0.4
HDL Cholesterol	0.1	0.1	0.2	0.4	0.3	0.1	0.3
LDL Cholesterol	0.2	0.3	0.5	0.7	0.7	-0.4	-0.3
Lupus	0.8	1.2	2.2	0.6	1.1	1.0	-1.5
Neuroticism (2016)	0.6	0.9	1.6	-0.7	0.1	1.2	-1.3
Primary Biliary Cirrhosis	1.8	2.6	5.5	0.5	-0.2	2.4	-2.1
Rheumatoid Arthritis	1.1	1.6	4.4	-2.1	0.4	-1.3	-0.2
Schizophrenia (2014)	1.3	2.8	6.2	0.1	1.2	1.9	-2.5
Triglycerides	0.3	0.5	0.7	-0.8	0.8	-0.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.1	1.2	0.1	-0.2
Ulcerative Colitis	0.8	1.2	2.8	-0.7	1.7	1.1	-0.5
Blood Eosinophil Count	0.1	0.5	0.9	-0.9	0.9	-0.4	-0.3
Blood Platelet Count	0.3	3.0	7.0	1.0	-2.6	-1.1	1.6
Blood Red Count	0.2	2.2	7.0	1.1	-0.3	-2.6	0.7
Blood White Count	0.0	0.3	1.0	0.2	-1.0	-0.0	0.2
Heel T-Score	1.9	15.0	37.8	4.2	-2.0	-1.0	6.2
BMI	0.0	0.2	0.4	0.0	0.6	0.4	0.6
Height	0.1	1.1	3.4	0.3	-0.8	-1.9	0.4
Waist Hip Ratio (WHR)	0.0	0.1	0.3	0.6	-0.1	-0.4	0.0
Systolic Blood Pressure	0.7	3.4	11.2	1.1	-3.4	0.5	0.9
Smoking Status	0.7	1.6	2.6	1.6	0.5	1.3	-1.3
Allergy or Eczema	1.5	4.0	12.5	-1.2	3.5	-0.0	-1.4
Cardiovascular Disease	0.0	0.1	0.2	-0.5	0.4	-0.0	-0.1
Hypothyroidism (self reported)	0.3	0.7	2.2	0.1	-0.3	-1.5	0.6
Respiratory disease	1.4	3.1	9.6	-0.8	3.1	0.2	-1.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.2	1.0	-1.1	0.3	1.0
Lung FEV1/FVC ratio	0.3	1.6	5.5	-0.2	-2.3	-0.8	-0.2
Lung FVC	0.9	4.7	7.2	-2.7	1.6	2.0	-2.2
Neuroticism	1.1	2.7	5.7	-1.4	1.6	0.8	-2.4
Chronotype (morning person)	0.2	0.5	1.2	-0.4	1.1	0.3	0.7
Hair Pigment	0.0	0.7	1.6	0.9	-0.5	-1.2	0.1
Tanning	0.1	1.6	2.6	-1.4	1.6	0.1	-1.3
Hand grip strength (left)	0.3	0.9	2.6	0.3	-0.8	1.6	-0.5
Number of treatments/medications taken	0.3	0.6	1.9	-0.3	1.4	-0.3	-0.5
Average weekly spirits intake	0.5	0.6	1.5	0.6	-0.8	-1.2	0.3
Sensitivity / hurt feelings	1.5	2.6	3.7	-1.4	1.9	1.6	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.1	1.0	0.8	1.0	0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-0.2	-0.5	-0.6	1.1
Relative age of first facial hair	0.6	1.2	2.7	-0.3	0.7	-1.6	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.0	1.7	0.7	-0.8	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.2	-0.6	0.6	0.3
Ever had hysterectomy (womb removed)	1.0	1.1	2.3	-0.9	1.5	0.4	-1.0
Systolic blood pressure, automated reading	0.5	1.4	3.9	1.1	-2.0	0.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	0.3	0.0	-0.9	0.2
Angina	1.4	1.9	6.5	2.5	0.9	-0.4	-0.3
Medication for hormone replacement therapy	0.3	0.3	0.9	-1.0	-0.5	-0.1	0.5
Vitamin and mineral supplements	0.5	0.7	1.5	-0.9	-0.3	1.2	-0.7
Supplements: Zinc	0.1	0.1	0.5	0.7	-0.2	-0.1	-0.1
Medication: Co-codamol	2.9	3.4	6.7	2.6	-0.4	-0.2	2.5
Medication: Metformin	0.2	0.3	0.4	0.7	-0.5	0.3	0.6
Diabetes (father)	0.5	0.6	1.1	0.7	-0.8	1.1	0.4
Diabetes (mother)	0.5	0.6	0.9	-1.0	-0.4	0.8	-0.8
Severe depression (siblings)	1.8	2.0	4.2	-0.8	1.5	1.1	-2.0
Pack years adult smoking proportion	0.3	0.5	1.1	-1.1	-0.9	0.2	0.1
Impedance of leg (right)	0.2	1.0	1.5	-1.1	1.2	-0.0	-1.1
Leg fat-free mass (left)	0.0	0.2	0.3	0.1	-0.6	0.1	0.5
Trunk fat percentage	0.1	0.2	0.6	0.3	0.3	0.3	0.8
Hand grip strength (right)	0.5	1.5	3.2	0.5	-1.8	1.5	-0.5
Townsend deprivation index at recruitment	0.8	1.1	2.2	-1.1	1.5	0.5	-0.9
Current tobacco smoking	0.1	0.2	0.7	0.8	-0.3	0.1	0.4
Average weekly fortified wine intake	1.0	1.2	2.1	-0.6	1.4	1.0	-1.1
Maternal smoking around birth	0.6	0.9	2.9	1.7	0.4	-0.1	0.6
Fed-up feelings	0.0	0.1	0.3	-0.0	0.5	0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.7	0.7	0.1	0.2
Relative age voice broke	0.6	0.9	1.9	-0.4	0.0	-1.4	1.3
Taking other prescription medications	0.2	0.3	0.8	0.9	-0.2	0.3	0.2
Age when periods started (menarche)	1.0	2.3	6.4	-1.2	2.5	0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	-1.2	0.3	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	3.7	8.4	21.6	2.6	-1.8	-1.4	4.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.2	-0.8	0.0	0.1
Qualifications: CSEs or equivalent	0.6	0.8	1.5	1.2	0.5	-0.8	1.0
Serious illness, injury or assault to yourself	0.7	0.9	2.5	1.6	0.9	0.4	-0.1
High blood pressure	0.1	0.4	0.7	-0.9	0.8	-0.5	-0.2
Hayfever, allergic rhinitis or eczema	1.4	3.0	9.4	-1.1	3.1	-0.0	-1.3
Multivitamins +/- minerals	0.3	0.4	1.2	-0.0	0.2	-1.1	0.4
Stomach or abdominal pain in last month	0.2	0.2	0.9	-0.2	-0.3	0.9	0.1
Supplements: Glucosamine	0.1	0.2	0.4	0.1	-0.4	-0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.1	0.7	0.0	-0.5
Medication: Atenolol	0.8	1.0	2.5	-1.6	0.4	-1.2	0.2
Medication: Levothyroxine sodium	1.2	2.0	3.6	0.1	-1.9	-1.2	1.7
Sitting height	0.0	0.3	0.5	-0.7	-0.5	-0.7	-0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.4	0.1	-0.4	1.0
High blood pressure (mother)	0.5	0.7	1.3	-1.1	-0.1	0.9	-0.8
Body mass index (BMI)	0.1	0.5	1.3	0.6	-0.2	0.6	1.2
Impedance of leg (left)	0.3	1.3	2.4	-1.2	1.2	0.2	-1.6
Leg predicted mass (left)	0.0	0.2	0.3	0.1	-0.6	0.1	0.5
Trunk fat mass	0.1	0.2	0.6	0.4	-0.1	0.5	0.8
Waist circumference	0.0	0.1	0.2	-0.4	-0.4	0.1	0.5
Number of incorrect matches in round	0.4	0.6	1.3	0.7	-1.1	0.9	-0.3
Past tobacco smoking	0.5	0.9	1.5	-0.7	-1.2	-1.1	0.7
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	-0.0	-0.4	-0.4
Nervous feelings	0.1	0.2	0.6	-0.4	0.8	0.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.7	-0.1	0.4	-0.4
Hearing difficulty/problems with background noise	0.3	0.5	1.3	0.2	-1.1	-0.1	0.7
Hair/balding pattern: Pattern 2	0.7	1.0	2.3	-1.1	-0.4	-0.3	1.5
Had menopause	0.1	0.1	0.3	-0.1	-0.5	-0.1	-0.0
Had other major operations	0.6	0.7	2.3	-1.5	0.6	-0.3	0.0
Forced vital capacity (FVC)	0.4	1.7	4.5	-2.1	0.5	0.5	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.3	17.9	2.3	-1.4	-0.7	4.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	0.2	0.4	-1.3	0.3
Qualifications: None of the above	0.2	0.5	0.8	0.4	0.9	0.5	-0.9
Financial difficulties in last 2 years	1.4	1.8	3.6	-0.7	1.9	0.7	-1.6
Mouth/teeth dental problems	0.2	0.3	0.7	-0.8	-0.2	-0.5	-0.5
Heart attack	1.0	1.3	4.1	-0.5	2.0	-0.2	-0.8
Allergy	1.7	3.8	9.6	1.8	-3.1	0.3	1.6
Pain all over the body in last month	1.7	1.8	4.5	2.1	0.9	-1.0	1.1
Diabetes (self-reported)	0.3	0.5	1.3	1.1	-0.2	0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	4.1	-1.8	1.9	1.9	-2.0
Medication: Ramipril	0.2	0.3	0.9	-0.0	-0.1	-0.4	1.0
Medication: Simvastatin	1.9	2.8	4.7	1.8	-1.0	-1.5	2.2
Fluid intelligence score	3.2	6.6	12.5	-3.5	2.3	1.8	-2.3
Illnesses of siblings	0.7	1.0	2.4	-0.9	0.6	0.8	-1.6
Neuroticism score	0.9	1.8	4.0	-0.6	2.0	0.5	-1.6
Weight	0.1	0.4	1.1	0.3	-0.6	0.2	1.0
Impedance of arm (right)	0.1	0.6	1.5	0.1	1.0	-1.2	0.1
Arm fat percentage (right)	0.1	0.5	1.8	0.5	-0.2	-0.1	1.3
Trunk fat-free mass	0.1	0.5	1.8	-0.3	-1.4	0.3	0.1
Hip circumference	0.1	0.5	0.8	-0.9	-0.7	-0.2	0.8
Time employed in main current job	0.4	0.5	1.0	1.0	0.1	0.9	0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.7	-0.8	1.3	0.2	-0.7
Father’s age at death	0.1	0.1	0.2	0.4	-0.2	0.3	-0.4
Worrier / anxious feelings	1.2	2.3	4.0	-0.6	1.6	1.4	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.6	0.7	-0.2	0.0
Falls in the last year	0.7	1.0	2.1	1.2	1.5	-0.6	0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.3	-0.3	0.1	-0.5
Number of live births	1.6	2.3	3.5	1.9	-1.3	-1.4	1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.2	-1.1	-0.8	0.1	-0.7
Pulse rate	0.2	0.4	1.0	1.0	0.7	0.1	0.3
Happiness	0.2	0.3	0.7	0.3	-0.8	0.0	0.7
Noisy workplace	2.1	2.6	3.3	1.8	-1.2	-1.6	1.7
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.3	0.6	-1.0	-2.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	6.5	-0.3	2.5	-2.0	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.8	0.1	0.9	-0.1	-0.4
Asthma	1.7	3.4	10.2	-1.4	3.2	0.3	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.6	0.6	1.6	0.1	0.7
Medication: Cholesterol lowering	0.6	0.9	1.9	1.4	-0.5	-0.8	0.9
Depression (self-reported)	1.5	1.8	3.9	1.1	2.0	0.2	1.4
Medication: Lansoprazole	0.3	0.3	0.7	0.8	0.5	0.3	0.5
Prospective memory result	0.5	0.7	1.3	-0.1	-1.2	-1.1	0.1
Lung cancer (father)	0.3	0.3	1.1	-1.0	0.3	-0.2	-0.2
Illnesses of mother	0.2	0.2	0.4	0.4	-0.6	0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.6	-1.3	-0.2	-0.7	-0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	1.0	0.1	1.0	-0.7
Impedance of arm (left)	0.1	0.3	0.7	-0.0	0.7	-0.9	-0.2
Arm fat mass (right)	0.1	0.5	1.5	0.2	-0.6	0.4	1.2
Trunk predicted mass	0.1	0.6	2.1	-0.2	-1.5	0.3	0.2
Standing height	0.1	0.7	1.6	-0.4	-1.3	-0.9	0.0
Length of working week for main job	0.2	0.3	0.9	0.3	0.9	-0.3	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.6	1.3	-0.7	0.1	0.6
Breastfed as a baby	1.0	1.2	2.3	0.0	-1.4	-0.6	1.5
Tense / ‘highly strung’	0.3	0.5	1.0	1.0	0.7	-0.6	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	0.1	0.3	0.9	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	-0.6	0.8	0.2	-0.9
Birth weight of first child	0.1	0.2	0.5	-0.1	-0.5	-0.5	-0.7
Peak expiratory flow (PEF)	0.7	1.7	4.1	1.6	-2.0	0.4	0.1
Pulse wave reflection index	0.6	0.7	1.5	-1.2	-0.5	0.4	-0.9
Ever highly irritable/argumentative for 2 days	1.9	2.3	6.1	1.0	-0.2	-2.5	1.5
Loud music exposure frequency	1.1	1.2	2.0	1.2	-1.2	-1.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.0	0.9	-0.2	-1.5	1.7
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	6.7	1.3	-1.5	-0.3	2.6
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.7	-0.3	0.5	-1.0
Medication: Paracetamol	0.6	0.9	2.2	0.9	1.5	-0.5	0.6
Headache pain in last month	1.2	2.1	6.5	-0.7	2.5	-0.3	-1.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.7	-1.0	0.2	1.0	-1.3
Glaucoma (self-reported)	1.1	1.3	4.0	-0.9	-0.2	2.0	-0.6
Gout (self-reported)	0.6	0.8	2.4	0.7	-0.6	0.3	1.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.3	0.1	-0.6	-1.8	1.0
Medication: Amlodipine	0.1	0.2	0.5	0.2	-0.1	0.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.3	0.7	0.1	-0.4
Birth weight	1.0	2.2	5.1	0.9	-2.2	-1.0	1.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	6.6	-0.3	2.6	-0.6	-0.5
High blood pressure (siblings)	0.3	0.5	1.3	0.2	-0.1	-0.7	1.1
Forced vital capacity (FVC), Best measure	0.4	1.6	3.8	-2.0	0.6	-0.7	-1.3
Body fat percentage	0.1	0.2	0.5	0.1	0.1	0.5	0.7
Leg fat percentage (right)	0.1	0.3	0.8	0.1	0.2	0.9	0.5
Arm fat-free mass (right)	0.1	0.4	0.7	-0.5	-0.8	0.8	0.1
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-1.0	-0.4	-0.6	0.2
Comparative body size at age 10	1.7	4.7	9.6	2.6	-3.1	0.2	1.6
Number of full brothers	1.0	1.3	1.9	-0.7	-1.2	-1.1	1.4
Worry too long after embarrassment	0.2	0.3	0.5	-0.5	0.5	0.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.1	0.1	0.8	0.3
Wheeze or whistling in the chest in last year	0.5	0.8	1.1	-1.1	0.7	1.1	-0.7
Number of children fathered	0.7	0.8	1.6	0.9	-0.6	0.6	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.2	-0.8	-0.8	1.0
Age at first live birth	0.1	0.1	0.3	0.3	-0.5	0.3	-0.1
Pulse wave peak to peak time	0.7	0.8	1.6	-1.0	-0.1	-1.3	0.9
Health satisfaction	0.4	0.5	1.4	0.5	-0.5	0.0	1.2
Shortness of breath walking on level ground	1.5	1.8	5.6	-0.2	2.4	0.9	-0.9
Qualifications: College or University degree	0.5	1.5	4.3	-0.3	-2.1	-0.3	1.3
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.7	-1.0	-0.7	0.6
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.8	1.2	0.1	0.3	1.7
Emphysema/chronic bronchitis	0.4	0.4	1.4	0.3	1.2	-0.3	0.4
Medication for pain relief, constipation, heartburn	1.0	1.7	3.8	-1.2	-1.9	-1.2	0.4
Neck or shoulder pain in last month	0.2	0.3	0.8	0.4	0.9	0.4	-0.3
Medication: Blood pressure	0.4	0.7	1.2	0.8	0.4	-1.1	1.0
Angina (self-reported)	1.1	1.5	5.4	2.3	0.6	-0.4	-0.2
Migraine (self-reported)	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1
Medication: Ibuprofen	0.8	1.0	1.8	1.0	1.3	-0.4	1.0
Medication: Allopurinol	0.1	0.2	0.7	0.0	0.1	0.3	0.8
Medication: Omeprazole	4.0	4.7	11.1	-1.9	1.3	1.7	-3.3
Medication: Seretide 50 evohaler	0.7	0.8	1.4	1.2	1.2	-0.3	0.6
Mean time to correctly identify matches	0.6	1.2	1.6	-1.2	1.3	-0.9	0.9
Heart disease (mother)	0.4	0.5	1.7	-1.3	-0.1	0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	-0.2	-1.2	0.0	-0.2
Whole body fat mass	0.1	0.3	0.8	0.2	-0.2	0.6	0.9
Leg fat mass (right)	0.0	0.2	0.5	0.0	-0.1	0.7	0.5
Arm predicted mass (right)	0.1	0.5	1.4	-0.1	-1.2	0.5	0.5
Pulse rate, automated reading	0.2	0.7	0.9	0.6	0.9	0.8	-1.0
Alcohol intake frequency.	0.2	0.4	0.6	-0.3	0.8	-0.6	-0.7
Comparative height size at age 10	0.4	2.2	5.9	1.7	-2.4	0.0	0.1
Number of full sisters	0.3	0.3	0.6	-0.3	0.5	0.8	-0.6
Suffer from ‘nerves’	0.7	1.1	2.4	-0.0	1.5	-1.4	-0.0
Overall health rating	0.8	1.7	3.6	1.0	-0.3	-1.5	1.9
Chest pain or discomfort	0.6	0.9	1.2	1.1	0.9	-0.6	1.1
Had major operations	0.4	0.5	1.8	-0.2	0.2	-1.3	-0.1
Age at last live birth	0.6	0.9	1.3	-1.0	0.3	1.0	-1.2
Family relationship satisfaction	0.8	1.0	3.4	-0.7	-1.9	0.1	-0.4
Leg pain on walking	0.4	0.5	0.8	0.9	0.7	-0.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	1.3	-0.0	1.0	-0.3
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.2	1.8	1.3	1.2	-0.5
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	8.6	0.3	-2.9	-1.0	1.8
Medication: Aspirin	1.2	1.6	3.4	1.4	1.8	0.4	-0.8
Supplements: Vitamin C	0.2	0.2	0.4	0.6	-0.6	0.1	0.4
Knee pain experienced in last month	0.2	0.2	0.8	-0.9	0.4	-0.1	-0.1
Hypertension (Self-reported)	0.2	0.7	1.2	-1.0	1.1	-0.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.9	0.3	-0.4	-0.5
Illnesses of father: Heart disease	0.7	1.0	3.0	-0.3	1.0	-0.0	-1.7
Illnesses of siblings: Diabetes	0.5	0.6	2.0	-0.3	1.4	-0.5	-0.2
Smoking status: Previous	1.0	1.5	3.1	1.2	1.1	1.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	-1.0	0.3	-0.5	0.3
Whole body fat-free mass	0.1	0.3	1.2	-0.1	-1.1	0.2	0.3
Leg fat-free mass (right)	0.0	0.1	0.4	0.1	-0.6	0.1	0.3
Arm fat percentage (left)	0.1	0.4	1.2	0.4	-0.1	0.4	1.1
Average weekly red wine intake	0.2	0.3	0.6	0.6	-0.3	0.7	0.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.9	-0.7	0.5	1.4	-1.4
Mood swings	0.1	0.2	0.2	0.4	0.3	-0.3	0.5
Loneliness, isolation	0.5	0.7	1.3	-1.2	0.9	0.8	0.3
Long-standing illness, disability or infirmity	0.6	0.9	2.7	1.6	0.8	0.5	-0.0
Ever had bowel cancer screening	0.1	0.2	0.4	0.3	-0.4	0.1	0.6
Diabetes diagnosed by doctor	0.2	0.4	1.1	1.0	-0.2	0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.2	-1.8	1.4	-0.1	-1.2
Friendships satisfaction	0.5	0.6	2.0	-0.3	0.1	-1.4	0.6
Qualifications: nursing, teaching	0.6	0.9	2.7	1.6	-0.5	-0.1	0.7
Commuting to job workplace: Walk	0.7	0.8	2.0	-0.3	-0.2	-1.4	1.1
Eye problems/disorders: Cataract	2.1	2.5	5.6	-1.6	1.1	0.8	-2.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.5	-0.9	1.9	0.0	-0.7
Medication for cholesterol	0.3	0.5	1.1	1.1	0.0	-0.8	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.4	0.4	2.3	0.0	-0.7
Back pain experienced in last month	1.0	1.5	5.5	2.4	-0.5	0.0	0.5
Mineral and other dietary supplements	0.5	0.7	1.3	-0.7	-0.7	-1.1	0.5
Breast cancer (self-reported)	0.3	0.4	1.0	-0.5	0.3	-1.0	0.5
Asthma (self-reported)	1.7	3.3	10.0	-1.3	3.2	0.3	-1.2
Osteoporosis (self-reported)	0.6	0.7	2.3	0.4	-1.5	-0.4	0.5
Osteoarthritis (self-reported)	0.8	1.0	2.6	1.6	0.9	0.7	-0.5
Medication: Aspirin	0.9	1.2	2.7	1.2	1.7	0.4	-0.7
Medication: Gliclazide	0.3	0.4	1.2	0.3	-0.1	0.4	-1.1
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	0.4	0.9	-0.4	0.4
Smoking status: Current	0.1	0.1	0.3	0.5	-0.2	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	3.5	-1.8	1.9	0.1	-1.8
Whole body water mass	0.1	0.3	1.2	-0.0	-1.1	0.3	0.3
Leg predicted mass (right)	0.0	0.1	0.3	-0.0	-0.6	0.1	0.2
Arm fat mass (left)	0.1	0.5	1.3	0.4	-0.5	0.4	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.1	-0.3	1.5	0.3	-1.3
Average weekly champagne plus white wine intake	0.4	0.6	1.0	-1.0	-0.2	-0.7	-0.9
Miserableness	0.3	0.5	1.3	1.1	0.2	0.8	-0.2
Guilty feelings	0.5	0.8	1.9	0.7	1.4	0.1	-0.9
Wears glasses or contact lenses	1.1	1.3	4.3	-0.4	2.1	-0.4	-0.7
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.0	0.3	0.5	0.8
Hearing aid user	1.1	1.2	3.7	-0.7	1.9	-0.7	-0.5
Mother’s age at death	0.2	0.2	0.4	-0.5	-0.6	0.0	0.3
Financial situation satisfaction	2.4	2.9	4.9	-2.0	1.3	1.0	-2.2
Tinnitus: Yes, now most or all of the time	1.8	2.1	6.0	0.8	-2.4	1.2	0.3
Commuting to job workplace: Public transport	2.6	3.1	4.9	-1.1	-1.8	-1.8	2.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-1.0	-0.2	0.7	0.3
Medication: Blood pressure	0.2	0.3	0.9	-1.0	0.1	-0.0	-0.6
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.0	2.0	1.1	-0.2	1.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.6	1.6	0.5	0.8	-0.3
High cholesterol (Self-reported)	0.2	0.3	0.7	0.8	-0.4	0.2	0.6
Medication: Bendroflumethiazide	0.3	0.5	1.6	0.3	0.2	-1.3	-0.6
Medication: Paracetamol	0.4	0.6	1.3	1.1	1.1	0.0	0.3
Medication: Lisinopril	0.8	1.1	1.8	-0.7	-0.6	-1.3	1.3
Medication: Atorvastatin	0.6	0.7	1.6	1.1	-0.4	1.3	-0.0
Illnesses of father: High blood pressure	0.2	0.2	0.7	-0.0	0.2	0.8	-0.5
Alcohol drinker status: Never	3.2	3.8	8.1	2.8	-1.6	-1.0	1.9
Ever smoked	0.3	0.5	1.3	-0.3	1.1	0.5	-0.5
Basal metabolic rate	0.0	0.2	0.6	-0.1	-0.8	0.3	0.3
Leg fat percentage (left)	0.1	0.3	0.9	0.0	0.3	1.0	0.3
Arm fat-free mass (left)	0.1	0.4	1.2	-0.4	-1.1	0.3	0.5
Number of operations (self-reported)	0.6	0.9	1.5	-1.2	1.1	-0.9	-0.4
Average weekly beer plus cider intake	0.8	1.1	2.6	-0.3	0.9	1.0	-1.6
Irritability	0.5	0.8	2.7	0.2	1.6	-0.6	0.4
Risk taking	0.8	1.2	2.2	0.6	1.5	1.5	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	-0.3	0.4	0.4	-1.0
Fractured/broken bones in last 5 years	1.1	1.4	3.5	-1.9	-1.4	-0.2	0.0
Age started oral contraceptive pill	1.7	2.1	5.2	1.3	-0.9	-0.9	2.3
Diastolic blood pressure, automated reading	0.4	1.3	3.5	-0.7	0.1	1.0	-1.9
Ever depressed for a whole week	0.7	0.8	1.2	0.5	-0.9	-0.9	1.1
Unable to work because of sickness or disability	1.2	1.5	2.4	1.3	1.6	0.6	-1.2
Commuting to job workplace: Cycle	0.7	0.8	1.9	0.2	0.1	-1.1	1.4
Myopia	0.3	0.4	1.2	-0.5	0.4	0.4	-1.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	0.3	-0.9	0.4	0.3
Cholesterol lowering medication	0.9	1.3	2.3	1.5	-1.2	0.1	1.2
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	9.6	-1.6	1.3	1.6	-3.1
Pain experienced in last month	0.6	1.0	3.5	-0.7	-1.9	-0.0	-0.1
Supplements: Calcium	1.3	1.4	4.6	2.1	0.8	0.6	-0.4
Basal cell carcinoma (self-reported)	1.1	1.3	2.0	-0.8	-0.9	-1.4	1.4
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.4	-0.5	1.8	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.7	-0.4	0.3	-0.7
Heart disease (siblings)	0.2	0.2	0.4	0.4	0.2	-0.6	-0.4
Alcohol drinker status: Previous	0.5	0.6	1.7	0.4	1.3	0.2	-0.7
Pack years of smoking	0.3	0.5	1.2	-0.8	-1.1	0.2	-0.1
Impedance of whole body	0.1	0.6	1.1	-0.7	1.0	-0.4	-0.7
Leg fat mass (left)	0.0	0.1	0.4	-0.0	-0.0	0.6	0.4
Arm predicted mass (left)	0.1	0.4	1.2	-0.3	-1.1	0.2	0.4