Hub : Genes

KIAA1211L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.139	0.058	0.00160	0.092	NA	0.077	NA	0.081	9.6e-07	NA	7.8e-06	NA	4.4e-06
2	GTEx	Esophagus Muscularis	0.319	0.084	0.00045	0.116	NA	0.132	NA	0.142	1.6e-07	NA	2.1e-08	NA	5.9e-09
3	GTEx	Skin Not Sun Exposed Suprapubic	0.150	0.057	0.00015	0.093	NA	0.057	NA	0.085	9.1e-06	NA	4.5e-04	NA	2.2e-05
4	GTEx	Skin Sun Exposed Lower leg	0.089	0.045	0.00320	0.052	NA	0.050	NA	0.046	3.7e-05	NA	5.4e-05	NA	1.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	5.0	8.0	15.5	1.8	-0.9	3.9	3.5
Bipolar Disorder or Schizophrenia	0.9	2.1	5.3	-0.0	0.4	2.3	1.7
Depressed Affect (Nagel 2018)	0.7	1.5	3.8	-1.9	-0.7	-0.1	1.4
Depression (Nagel 2018)	1.2	1.8	5.8	-2.4	-1.2	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	0.8	-1.4	-0.3	-1.2
Neuroticism (Nagel 2018)	0.7	1.7	5.3	-2.3	0.3	-0.5	1.0
Schizophrenia (2018)	0.4	0.9	2.4	-1.5	0.9	-0.2	-0.7
Schizophrenia vs Biploar Disorder	9.3	12.3	21.5	-2.8	-0.1	-4.4	-4.6
Worry (Nagel 2018)	0.5	1.0	2.5	-1.6	1.0	-0.2	0.8
Alzheimer’s Disease (in mother)	1.1	1.3	3.8	0.3	-2.0	1.1	0.1
Alzheimer’s Disease (in father)	0.8	0.9	3.1	0.1	-1.8	-0.3	-0.5
Alzheimer’s Disease (including proxy)	1.0	1.4	5.1	0.2	-2.3	0.4	-0.5
Crohns Disease (2017)	0.1	0.3	0.8	-0.4	-0.3	0.4	0.9
Irritable Bowel Disease (IBD)	0.3	0.6	1.3	-1.1	0.2	-1.0	-0.4
Ulcerative Colitis (UC)	0.6	1.2	2.3	-1.0	1.0	-1.5	-0.7
Major Depression (MDD)	1.0	1.2	4.3	-2.1	-0.1	0.0	-0.7
Reaction Time	0.2	0.5	1.3	0.2	1.2	0.1	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.4	0.1	-1.5	-0.2	-1.1
Breast Cancer	0.1	0.2	0.5	-0.4	0.5	0.7	0.1
Ovarian Cancer	0.3	0.4	1.1	0.3	0.3	-0.5	-1.1
Prostate Cancer	0.8	1.1	3.6	-0.4	1.9	-0.2	0.7
Age at First Birth	1.2	1.8	5.2	-1.0	-2.3	-0.7	-0.8
Bipolar Disorder (2011)	2.8	2.7	6.4	-0.3	0.0	2.5	2.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.1	-1.1	-0.6	-0.5	-0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.2	0.0	0.5	0.7
Crohns Disease (2012)	1.3	2.1	4.2	0.6	-1.2	2.0	1.6
Mean Putamen Volume	0.4	0.5	1.1	-0.5	-0.4	-0.5	-1.1
Fasting Glucose	2.5	3.0	5.1	-1.3	1.5	-2.3	-1.8
HbA1C	0.2	0.3	1.0	-0.2	-1.0	0.1	-0.0
HDL Cholesterol	0.3	0.5	1.4	-0.2	-1.2	0.3	0.6
LDL Cholesterol	0.1	0.1	0.2	0.5	0.2	0.3	-0.1
Lupus	0.4	0.6	1.8	-0.6	-1.3	0.3	0.0
Neuroticism (2016)	2.1	3.0	5.5	-1.9	2.4	-1.2	-1.2
Primary Biliary Cirrhosis	1.2	1.6	2.7	-1.6	0.6	-1.6	-1.0
Rheumatoid Arthritis	1.4	2.0	4.8	-0.5	-0.2	1.6	2.2
Schizophrenia (2014)	0.3	0.7	1.3	-1.2	0.7	-0.2	-1.0
Triglycerides	0.9	1.5	5.7	-0.4	2.4	-0.0	-0.4
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.8	-1.1	2.0	-1.2	-0.6
Ulcerative Colitis	1.1	1.6	2.4	-0.9	1.2	-1.3	-1.5
Blood Eosinophil Count	1.8	14.0	30.6	-1.1	-0.5	-5.5	-4.9
Blood Platelet Count	0.1	0.9	3.0	0.5	1.7	0.5	0.3
Blood Red Count	0.2	1.7	3.4	-1.8	1.7	0.4	0.7
Blood White Count	0.3	2.2	5.7	0.0	2.4	1.5	0.8
Heel T-Score	0.7	5.8	9.3	2.5	0.2	2.8	3.0
BMI	0.9	5.1	5.9	-2.4	2.1	-2.2	-2.2
Height	0.1	2.1	4.9	-0.1	-0.1	-2.2	-1.9
Waist Hip Ratio (WHR)	0.8	3.7	7.0	-0.2	2.6	-1.8	-2.1
Systolic Blood Pressure	0.4	1.9	3.6	-1.8	-0.5	-0.6	-1.9
Smoking Status	3.8	9.2	18.6	2.8	-1.5	4.3	2.8
Allergy or Eczema	1.8	4.7	8.8	-1.7	0.6	-3.0	-2.7
Cardiovascular Disease	0.2	0.8	1.6	-1.3	1.2	0.0	-0.2
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.0	-0.8	0.8	-0.1
Respiratory disease	2.5	5.5	12.5	-1.3	-0.5	-3.5	-2.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.6	-0.1	1.3	-0.2	-0.2
Lung FEV1/FVC ratio	3.3	16.7	32.5	2.9	2.1	5.7	4.6
Lung FVC	0.4	1.9	3.3	-0.9	-1.1	-1.8	-1.4
Neuroticism	0.9	2.2	6.5	-2.5	0.8	-0.3	1.2
Chronotype (morning person)	0.5	1.2	2.9	0.4	0.2	1.7	1.3
Hair Pigment	0.0	0.2	0.6	-0.3	-0.3	-0.2	0.8
Tanning	0.1	1.7	3.0	1.3	-0.2	1.7	1.5
Hand grip strength (left)	0.2	0.6	1.1	0.0	-1.0	-1.0	-0.7
Number of treatments/medications taken	0.3	0.5	0.8	0.9	0.9	0.4	-0.6
Average weekly spirits intake	0.2	0.2	0.6	-0.3	-0.3	0.1	0.8
Sensitivity / hurt feelings	0.7	1.2	2.9	-1.7	0.7	-0.5	1.0
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.4	-1.5	-1.2	0.2	0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.5	0.1	-0.5	-1.2	-0.4
Relative age of first facial hair	0.2	0.4	0.9	-0.1	0.1	1.0	0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.7	-0.2	-0.1	-0.3
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.9	-0.9	2.2	-1.2	-0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.6	-0.4	0.3	0.3
Systolic blood pressure, automated reading	1.1	3.3	7.2	-2.2	-0.5	-1.1	-2.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.2	0.8	-1.1	0.6	0.8
Angina	0.9	1.2	2.3	-0.5	1.5	-0.4	-1.4
Medication for hormone replacement therapy	0.7	0.8	2.8	-0.6	1.7	-0.0	-0.2
Vitamin and mineral supplements	0.9	1.2	4.7	-0.2	-2.2	-0.2	0.3
Supplements: Zinc	0.2	0.2	0.9	0.9	0.0	-0.1	0.0
Medication: Co-codamol	1.0	1.2	4.5	-0.0	2.1	0.5	-0.0
Medication: Metformin	0.6	0.9	2.3	-0.7	0.3	-0.8	-1.5
Diabetes (father)	2.5	3.0	4.8	-1.6	1.3	-1.7	-2.2
Diabetes (mother)	1.6	2.1	5.8	0.3	2.4	0.5	1.5
Severe depression (siblings)	0.7	0.8	2.6	-1.6	0.3	-0.6	0.2
Pack years adult smoking proportion	0.7	1.0	2.7	-0.2	0.9	-0.7	-1.6
Impedance of leg (right)	0.5	2.3	5.6	1.2	-2.4	1.4	0.5
Leg fat-free mass (left)	1.0	5.5	7.3	-2.1	2.6	-2.7	-1.9
Trunk fat percentage	0.6	2.4	3.4	-1.4	1.3	-1.8	-1.6
Hand grip strength (right)	1.0	2.8	5.1	-0.6	-1.3	-2.3	-2.0
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.8	-0.1	0.7	-0.1
Current tobacco smoking	3.1	5.1	10.5	2.1	-1.3	3.2	2.0
Average weekly fortified wine intake	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.0
Maternal smoking around birth	0.2	0.3	1.0	-0.4	-1.0	0.3	0.3
Fed-up feelings	1.2	2.2	5.5	-1.3	1.1	0.5	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	5.3	-2.3	-1.4	0.2	-0.5
Relative age voice broke	0.7	1.0	2.1	1.1	-0.2	1.5	0.9
Taking other prescription medications	0.1	0.2	0.4	0.6	0.5	0.4	-0.1
Age when periods started (menarche)	0.1	0.2	0.4	0.4	-0.6	0.6	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	-0.6	-0.1	-0.0	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.6	-1.3	0.2	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	-1.3	-0.7	-0.9	-0.6
Qualifications: CSEs or equivalent	2.8	3.6	10.8	-3.3	-0.6	-1.2	-1.4
Serious illness, injury or assault to yourself	0.7	0.8	1.7	-1.3	-0.6	1.1	0.2
High blood pressure	0.5	1.5	2.9	-1.5	1.7	0.1	-0.9
Hayfever, allergic rhinitis or eczema	3.2	7.0	12.0	-2.3	0.4	-3.2	-3.5
Multivitamins +/- minerals	1.3	1.7	6.1	0.4	2.5	-0.4	-0.6
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.7	-0.0	-0.8	0.2
Supplements: Glucosamine	0.2	0.2	0.6	0.4	0.0	-0.4	-0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.7	-1.6	-0.5	0.0	-0.2
Medication: Atenolol	0.2	0.2	0.5	-0.0	-0.7	0.6	0.4
Medication: Levothyroxine sodium	0.1	0.3	0.7	-0.8	0.3	0.2	-0.4
Sitting height	0.3	2.1	4.6	0.1	-1.9	-2.1	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.5	0.4	-0.0	-0.2
High blood pressure (mother)	0.6	0.8	2.9	-0.3	0.3	0.3	1.7
Body mass index (BMI)	1.0	4.3	5.8	-2.3	2.4	-1.8	-1.8
Impedance of leg (left)	0.6	3.2	7.7	1.6	-2.8	1.4	0.6
Leg predicted mass (left)	1.0	5.3	7.4	-2.0	2.5	-2.7	-1.9
Trunk fat mass	0.8	3.5	4.7	-1.8	1.7	-2.2	-1.9
Waist circumference	2.0	7.3	9.6	-1.9	2.5	-3.1	-3.1
Number of incorrect matches in round	1.7	2.8	8.5	-0.0	0.2	1.6	2.9
Past tobacco smoking	2.2	4.0	5.7	-2.4	1.0	-2.2	-2.1
Alcohol usually taken with meals	0.9	1.4	3.6	0.3	1.0	1.0	1.9
Nervous feelings	0.1	0.2	0.3	-0.6	0.4	-0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	6.2	-2.5	0.0	-1.0	-0.6
Hearing difficulty/problems with background noise	2.9	4.6	6.5	-2.3	-0.5	-2.5	-2.5
Hair/balding pattern: Pattern 2	1.1	1.4	3.5	-1.9	1.1	-0.5	-0.8
Had menopause	1.1	1.3	3.4	0.4	1.9	-0.8	-1.1
Had other major operations	2.1	2.5	9.0	0.1	3.0	-0.7	-0.7
Forced vital capacity (FVC)	0.2	0.9	2.2	-0.1	-0.7	-1.5	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	-1.2	-0.0	-0.3	0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.5	0.3	1.9	-1.2	-0.7
Qualifications: None of the above	0.7	1.6	2.4	1.0	0.8	1.6	1.6
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.6	0.9	-0.4	-0.3
Mouth/teeth dental problems	0.2	0.3	0.6	-0.6	-0.8	-0.6	-0.1
Heart attack	0.6	0.7	1.7	-0.1	1.3	0.1	-1.1
Allergy	2.0	4.7	8.8	1.3	0.4	3.0	2.8
Pain all over the body in last month	3.4	3.6	7.3	-0.8	0.8	-2.4	-2.7
Diabetes (self-reported)	0.3	0.5	1.1	0.3	1.0	-0.2	-0.9
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	5.2	-2.3	0.2	-1.6	-1.9
Medication: Ramipril	0.7	0.9	1.6	-0.5	1.3	-1.1	-0.6
Medication: Simvastatin	0.4	0.6	1.0	-0.1	0.5	1.0	1.0
Fluid intelligence score	0.7	1.5	5.1	0.7	-2.2	0.1	-0.6
Illnesses of siblings	0.5	0.7	1.4	1.2	0.7	-0.7	-0.6
Neuroticism score	0.5	1.1	2.8	-1.7	0.5	-0.0	1.1
Weight	1.1	5.3	7.4	-2.2	2.2	-2.7	-2.1
Impedance of arm (right)	0.7	3.2	5.7	2.4	-1.7	1.5	1.5
Arm fat percentage (right)	0.5	1.9	3.0	-1.4	1.7	-1.2	-1.2
Trunk fat-free mass	0.5	2.8	3.3	-1.8	1.8	-1.7	-1.3
Hip circumference	1.3	5.6	9.0	-2.3	1.3	-3.0	-2.5
Time employed in main current job	1.0	1.2	2.9	-1.0	-1.7	-0.6	-0.7
Alcohol intake versus 10 years previously	0.2	0.4	1.0	1.0	-0.5	0.2	-0.4
Father’s age at death	1.9	2.6	9.0	1.0	-3.0	0.5	0.1
Worrier / anxious feelings	0.9	1.8	5.8	-0.4	2.4	0.0	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.1	-2.7	0.5	-1.3	-0.6
Falls in the last year	0.9	1.2	2.5	-1.6	0.6	-1.2	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.0	-0.3	0.5	0.7
Number of live births	0.4	0.6	1.9	1.4	-0.1	0.0	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.7	0.8	-0.1	-0.0	-0.1
Pulse rate	0.8	1.4	2.8	-0.4	1.4	-1.7	-0.7
Happiness	0.0	0.0	0.2	-0.1	-0.0	-0.4	0.1
Noisy workplace	0.1	0.1	0.5	0.0	-0.7	0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.7	1.2	-0.5	-1.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	0.4	-0.7	-0.6	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.5	-0.4	0.3	1.2	0.1
Asthma	0.8	1.6	3.3	0.2	-1.2	-1.8	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	0.5	-0.2	0.8	1.6
Medication: Cholesterol lowering	0.3	0.4	0.9	-0.7	-0.6	0.0	-1.0
Depression (self-reported)	1.3	1.6	5.2	-0.8	-2.3	0.8	-0.0
Medication: Lansoprazole	0.7	0.8	1.7	-0.4	1.3	-1.0	-0.5
Prospective memory result	0.9	1.1	2.0	-0.1	1.4	0.8	1.4
Lung cancer (father)	0.1	0.2	0.3	-0.5	-0.4	-0.2	-0.4
Illnesses of mother	0.2	0.2	0.6	0.4	0.8	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	1.7	-0.3	0.9	0.9
Pulse wave Arterial Stiffness index	2.3	2.6	4.7	-1.0	0.4	-2.2	-2.2
Impedance of arm (left)	0.3	1.5	3.2	1.8	-1.4	0.5	0.9
Arm fat mass (right)	1.0	4.1	5.0	-2.1	2.2	-2.1	-1.7
Trunk predicted mass	0.5	2.7	3.3	-1.8	1.8	-1.7	-1.3
Standing height	0.1	1.1	4.1	0.0	-0.1	-2.0	-0.7
Length of working week for main job	0.9	0.9	2.0	1.2	-1.4	-0.5	-0.3
Exposure to tobacco smoke at home	0.9	1.0	2.6	-1.6	-0.9	-0.2	-0.8
Breastfed as a baby	0.6	0.8	2.0	0.0	1.4	-1.1	-0.1
Tense / ‘highly strung’	0.3	0.5	0.8	-0.7	0.8	0.3	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	-0.7	-0.4	0.8	0.5
Hair/balding pattern: Pattern 4	1.4	3.3	3.9	1.7	-1.8	2.0	1.8
Birth weight of first child	0.2	0.3	0.9	-0.3	0.3	0.6	0.9
Peak expiratory flow (PEF)	0.2	0.5	1.1	1.1	-0.5	0.7	0.3
Pulse wave reflection index	1.1	1.3	2.4	-0.6	1.0	-1.5	-1.2
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.7	-1.5	-0.1	-2.2	-1.4
Loud music exposure frequency	1.2	1.4	1.8	-1.4	-1.3	-0.8	-1.1
Qualifications: O levels/GCSEs or equivalent	4.2	6.7	14.2	-0.8	-0.2	-3.8	-3.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.8	-0.3	0.8	-1.3	-1.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.1	-0.3	-0.1	-0.4
Medication: Paracetamol	0.8	1.4	3.6	-1.0	1.9	-0.9	-0.3
Headache pain in last month	0.3	0.5	1.6	-1.3	-0.3	0.4	0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	0.2	-0.1	-0.3	0.7
Glaucoma (self-reported)	0.8	0.9	1.2	1.0	-0.7	1.1	1.0
Gout (self-reported)	0.5	0.7	1.9	-1.4	-0.1	-0.9	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	0.0	-0.9	0.4	-0.2
Medication: Amlodipine	0.1	0.1	0.4	-0.2	0.2	-0.2	-0.7
Medication: Ventolin 100micrograms inhaler	1.8	2.4	4.9	-0.9	0.0	-2.2	-1.9
Birth weight	0.1	0.1	0.2	0.3	-0.3	0.4	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.4	0.4	-0.3	-0.6
High blood pressure (siblings)	0.4	0.6	1.5	-1.2	-0.5	-0.6	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	0.4	-0.8	-0.6	-0.4
Body fat percentage	0.7	2.8	3.2	-1.8	1.5	-1.8	-1.7
Leg fat percentage (right)	1.0	3.7	5.2	-2.3	1.6	-1.6	-2.1
Arm fat-free mass (right)	0.9	4.8	5.9	-2.2	2.2	-2.4	-1.9
Exposure to tobacco smoke outside home	1.0	1.3	3.7	-0.4	-1.9	-0.2	-1.2
Comparative body size at age 10	0.1	0.2	0.4	-0.3	0.6	-0.1	-0.6
Number of full brothers	0.4	0.5	0.8	0.6	0.9	0.6	0.8
Worry too long after embarrassment	0.7	1.2	4.1	-2.0	0.1	-0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	5.1	0.9	-2.3	1.9	1.3
Wheeze or whistling in the chest in last year	1.5	2.7	4.8	-0.5	-1.0	-2.2	-2.1
Number of children fathered	0.1	0.1	0.2	0.2	0.3	-0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-0.6	0.7	-1.2	-0.5
Age at first live birth	0.2	0.4	0.5	0.7	-0.4	0.6	0.7
Pulse wave peak to peak time	1.9	2.3	4.2	0.9	-0.3	2.1	2.0
Health satisfaction	1.4	1.8	5.2	-2.3	0.4	-0.9	-1.1
Shortness of breath walking on level ground	0.8	0.9	2.1	-0.5	1.1	-0.0	1.4
Qualifications: College or University degree	0.4	1.4	2.2	0.8	-1.0	-1.5	-1.2
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.5	0.8	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	0.9	-0.7	0.0	-0.1
Emphysema/chronic bronchitis	1.0	1.1	2.0	-1.3	1.4	-0.3	0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	0.8	-0.9	-0.3	-0.4
Neck or shoulder pain in last month	0.5	0.7	1.3	-1.2	-0.2	-0.3	-1.1
Medication: Blood pressure	0.1	0.2	0.3	-0.1	0.3	0.5	-0.6
Angina (self-reported)	0.5	0.7	1.3	-0.4	1.1	-0.2	-1.1
Migraine (self-reported)	0.4	0.6	1.8	0.4	-1.3	0.5	0.1
Medication: Ibuprofen	0.5	0.6	1.5	0.3	-0.7	0.6	1.2
Medication: Allopurinol	0.3	0.4	1.6	-1.3	0.0	-0.0	0.2
Medication: Omeprazole	0.7	0.9	2.1	-1.4	1.1	0.2	0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.6	-0.5	0.7	-1.3	-0.9
Mean time to correctly identify matches	0.1	0.2	0.5	-0.1	0.7	-0.4	0.2
Heart disease (mother)	0.3	0.3	1.1	-1.0	-0.2	0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	0.4	1.3	-0.2	0.5
Whole body fat mass	1.0	4.3	5.3	-2.0	1.9	-2.3	-2.0
Leg fat mass (right)	1.3	5.0	5.8	-2.4	2.0	-2.1	-2.4
Arm predicted mass (right)	0.8	4.3	4.9	-2.2	2.2	-2.2	-1.7
Pulse rate, automated reading	0.9	3.1	8.2	-0.6	2.9	-1.5	-1.2
Alcohol intake frequency.	0.6	1.5	3.9	-2.0	0.2	0.2	-1.4
Comparative height size at age 10	0.3	1.7	4.1	-0.9	2.0	-1.4	-0.5
Number of full sisters	2.7	3.3	3.8	-1.5	2.0	-1.9	-1.8
Suffer from ‘nerves’	0.4	0.6	2.3	0.1	1.5	-0.2	-0.2
Overall health rating	4.2	9.0	14.6	-3.8	3.0	-2.5	-2.5
Chest pain or discomfort	0.5	0.7	1.4	-1.1	-0.5	0.2	-1.2
Had major operations	0.5	0.6	1.1	-0.8	-1.0	-0.5	-0.8
Age at last live birth	0.2	0.2	0.8	0.3	-0.9	0.0	0.1
Family relationship satisfaction	0.1	0.1	0.3	-0.1	0.2	-0.4	-0.5
Leg pain on walking	0.1	0.1	0.4	-0.3	0.6	-0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.3	0.1	0.1	1.5	2.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.6	-0.6	1.6	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	0.7	0.0	0.5	-0.1
Medication: Aspirin	2.1	2.7	6.9	-0.8	-0.1	-1.9	-2.6
Supplements: Vitamin C	0.8	0.9	2.0	1.2	0.1	1.4	0.4
Knee pain experienced in last month	0.2	0.4	1.5	-1.2	0.2	0.1	-0.0
Hypertension (Self-reported)	0.5	1.5	2.7	-1.6	1.5	-0.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.0	0.6	0.2	0.5
Illnesses of father: Heart disease	0.3	0.4	1.0	0.0	-0.2	-1.0	-0.7
Illnesses of siblings: Diabetes	5.6	6.8	13.2	1.2	0.6	3.5	3.6
Smoking status: Previous	2.4	3.6	5.8	1.6	-1.0	2.3	2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.6	-0.2	-0.2	-2.1	-1.3
Whole body fat-free mass	0.7	4.1	5.1	-2.0	2.2	-2.3	-1.6
Leg fat-free mass (right)	0.9	4.6	6.9	-1.7	2.4	-2.6	-1.6
Arm fat percentage (left)	0.7	2.6	4.2	-1.5	2.1	-1.5	-1.4
Average weekly red wine intake	0.8	1.1	2.3	-0.4	-0.8	-1.5	-1.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.2	-1.8	0.3	-0.9	-0.9
Mood swings	0.9	1.7	3.9	-1.5	0.3	0.7	2.0
Loneliness, isolation	0.2	0.3	0.7	-0.8	0.1	-0.8	-0.0
Long-standing illness, disability or infirmity	2.0	3.0	4.9	-1.4	2.2	-1.4	-1.9
Ever had bowel cancer screening	0.6	0.7	1.6	0.4	0.3	0.9	1.3
Diabetes diagnosed by doctor	0.3	0.6	1.4	-0.3	0.8	-0.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.8	0.6	-0.9	-0.4	-0.5
Friendships satisfaction	0.9	1.1	1.7	-0.6	-1.2	-0.9	-1.3
Qualifications: nursing, teaching	0.3	0.5	1.5	-0.4	-1.2	-0.1	-0.5
Commuting to job workplace: Walk	1.9	2.0	6.2	0.3	-2.5	-0.9	-1.0
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.5	-0.4	0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.7	1.3	0.3	1.6	1.9
Medication for cholesterol	1.3	2.0	5.1	2.3	-1.3	0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.7	-1.6	-0.4	0.1	-0.4
Back pain experienced in last month	0.5	0.7	2.1	-1.4	0.9	0.2	0.0
Mineral and other dietary supplements	0.2	0.3	0.7	-0.9	0.1	0.1	0.6
Breast cancer (self-reported)	4.2	5.0	7.2	-1.8	2.0	-2.3	-2.7
Asthma (self-reported)	0.9	1.8	4.0	0.3	-1.2	-2.0	-1.3
Osteoporosis (self-reported)	1.9	2.3	3.2	1.8	-0.1	1.8	1.7
Osteoarthritis (self-reported)	0.5	0.6	1.4	-1.2	-0.6	0.9	0.0
Medication: Aspirin	2.9	3.7	9.4	-0.9	-0.5	-2.1	-3.1
Medication: Gliclazide	1.2	1.3	2.2	-1.2	0.3	-1.5	-1.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.4	-0.7	0.6	0.4
Smoking status: Current	4.3	6.9	13.6	2.6	-1.3	3.7	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.3	0.1	-0.0	-0.1	-0.6
Whole body water mass	0.6	3.4	4.2	-1.9	2.0	-2.0	-1.3
Leg predicted mass (right)	0.9	4.7	6.7	-1.7	2.5	-2.6	-1.6
Arm fat mass (left)	1.0	3.9	5.8	-1.8	2.4	-2.0	-1.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	-0.3	0.3	-0.1	-0.5
Average weekly champagne plus white wine intake	1.1	1.5	3.5	0.8	1.1	0.7	1.9
Miserableness	0.6	1.1	2.3	-1.3	-1.5	0.1	0.6
Guilty feelings	1.1	1.7	2.6	-0.0	-1.3	1.6	1.6
Wears glasses or contact lenses	0.4	0.5	1.4	1.2	-0.3	-0.4	-0.5
Ever taken oral contraceptive pill	1.0	1.1	1.7	0.4	-1.0	1.3	1.2
Hearing aid user	0.6	0.7	1.9	-1.4	-0.3	-0.7	-0.7
Mother’s age at death	0.9	1.1	1.4	1.0	-1.2	0.9	1.1
Financial situation satisfaction	0.1	0.2	0.4	0.2	0.3	-0.3	-0.6
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.7	1.9	0.5	1.0	1.4
Commuting to job workplace: Public transport	0.5	0.6	1.2	1.1	-0.1	-1.0	0.3
Eye problems/disorders: Glaucoma	1.1	1.3	1.8	0.6	-1.3	1.3	1.3
Medication: Blood pressure	0.8	1.6	3.6	-1.9	1.5	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-1.3	-0.5	0.5	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	0.8	0.2	0.8	-0.2
High cholesterol (Self-reported)	0.4	0.7	1.2	-0.8	0.6	1.1	0.8
Medication: Bendroflumethiazide	0.2	0.2	0.8	-0.9	-0.1	0.3	-0.3
Medication: Paracetamol	0.7	1.0	3.7	-0.2	1.9	-0.6	-0.0
Medication: Lisinopril	0.3	0.4	0.9	-0.5	0.5	0.2	-1.0
Medication: Atorvastatin	0.7	0.9	2.0	-0.9	-0.5	-0.8	-1.4
Illnesses of father: High blood pressure	0.4	0.5	1.5	0.1	-0.5	0.7	1.2
Alcohol drinker status: Never	0.4	0.5	0.9	-0.9	1.0	0.5	0.0
Ever smoked	2.3	4.0	9.8	3.1	-0.4	1.9	1.6
Basal metabolic rate	0.8	4.6	6.1	-2.2	2.2	-2.5	-1.7
Leg fat percentage (left)	0.9	3.3	3.9	-2.0	1.6	-1.7	-1.9
Arm fat-free mass (left)	0.7	3.7	4.5	-2.1	2.1	-2.0	-1.3
Number of operations (self-reported)	0.2	0.3	0.7	-0.7	0.1	-0.0	-0.9
Average weekly beer plus cider intake	1.0	1.5	5.3	-0.3	2.3	-0.6	0.3
Irritability	0.6	1.0	2.2	-1.3	0.6	-1.5	-0.1
Risk taking	0.5	0.8	1.0	1.0	-1.0	0.7	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.9	-0.0	-1.4	0.2	0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.6	-0.7	-0.8	0.6	0.6
Age started oral contraceptive pill	4.1	5.2	7.6	-2.5	-0.2	-2.6	-2.8
Diastolic blood pressure, automated reading	1.8	5.6	8.9	-3.0	-0.8	-2.3	-2.7
Ever depressed for a whole week	0.1	0.1	0.5	0.7	-0.1	-0.1	-0.1
Unable to work because of sickness or disability	0.7	0.8	2.0	-1.4	0.8	0.9	0.1
Commuting to job workplace: Cycle	1.6	2.0	4.4	0.3	-1.7	2.1	0.7
Myopia	0.5	0.7	2.3	0.5	1.5	-0.5	0.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.9	1.5	-2.0	0.2	1.6
Cholesterol lowering medication	0.8	1.2	2.8	-1.3	1.7	-0.0	0.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.1	-2.0	1.5	-0.8	-0.0
Pain experienced in last month	1.1	1.8	5.9	2.4	-0.6	0.4	1.0
Supplements: Calcium	0.6	0.7	1.5	0.5	1.2	-0.8	-0.6
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.4	-1.0	0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	-0.2	1.2	0.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.2	-0.5	0.3	-0.1
Heart disease (siblings)	0.2	0.2	0.4	0.1	0.1	0.7	0.6
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.5	-1.1	0.2	-0.6
Pack years of smoking	0.8	1.2	2.7	-0.2	1.3	-0.6	-1.6
Impedance of whole body	0.6	2.8	4.9	2.0	-2.2	1.0	1.0
Leg fat mass (left)	1.3	5.3	6.0	-2.5	2.0	-2.3	-2.4
Arm predicted mass (left)	0.7	3.6	4.8	-2.2	2.2	-1.8	-1.2