Hub : Genes

KLHL35

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.3430	0.1150	3.4e-03	0.237	NA	0.082	NA	0.116	8.8e-07	NA	4.0e-03	NA	6.9e-04
2	GTEx	Whole Blood	0.1480	0.0450	6.3e-05	0.112	NA	0.095	NA	0.095	1.7e-10	NA	4.7e-09	NA	4.9e-09
3	METSIM	Adipose	0.0815	0.0318	4.4e-04	0.022	0.037	0.024	0.039	0.030	2.4e-04	2.8e-06	1.2e-04	1.3e-06	2.4e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.0923	0.0300	1.3e-04	0.058	0.023	0.018	0.027	0.032	5.9e-08	5.2e-04	1.8e-03	1.9e-04	5.4e-05
5	YFS	Blood	0.2570	0.0414	0.0e+00	0.163	0.163	0.176	0.184	0.172	4.4e-51	4.8e-51	3.2e-55	5.4e-58	7.0e-54
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0173	0.0109	8.7e-03	0.013	0.015	0.004	NA	0.010	1.1e-02	6.8e-03	1.1e-01	NA	2.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.1	3.6	-1.9	1.2	-0.2	1.5	1.7	1.6
Bipolar Disorder or Schizophrenia	0.9	2.2	5.2	-2.3	1.3	0.2	1.5	1.0	1.7
Depressed Affect (Nagel 2018)	1.0	2.1	8.4	-0.0	-0.7	-2.9	-1.1	-1.4	-0.8
Depression (Nagel 2018)	1.0	1.5	6.6	0.3	-0.8	-2.6	-0.9	-0.6	-0.7
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.2	0.6	-1.2	1.8	-1.2	-1.0	-1.6
Neuroticism (Nagel 2018)	1.0	2.4	7.1	0.2	-1.4	-2.7	-1.4	-1.6	-0.9
Schizophrenia (2018)	0.3	0.7	2.0	-1.4	0.8	0.3	0.8	-0.1	0.9
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	-0.6	-0.8	0.2	-1.0	-0.6	-1.1
Worry (Nagel 2018)	0.1	0.1	0.4	0.0	-0.3	-0.7	-0.5	-0.0	-0.2
Alzheimer’s Disease (in mother)	3.7	4.4	6.8	-2.4	2.6	0.9	2.2	1.9	2.2
Alzheimer’s Disease (in father)	0.8	0.8	1.7	1.0	-1.1	-0.1	-0.7	-1.3	-0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	-0.9	1.2	0.1	0.9	0.5	0.7
Crohns Disease (2017)	0.6	1.4	7.6	0.4	0.3	2.7	0.0	0.5	0.6
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	1.0	-0.3	1.4	-0.1	-0.1	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.7	-0.4	-0.2	0.0	-0.3	-0.3
Major Depression (MDD)	0.2	0.2	0.7	0.8	-0.3	-0.1	-0.2	0.4	-0.7
Reaction Time	0.1	0.3	0.6	0.6	-0.1	-0.6	-0.0	-0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.0	0.4	-0.7	1.4	-0.5	-0.3	-0.4
Breast Cancer	0.3	0.7	1.5	0.2	-0.9	-1.2	-0.9	-0.9	-0.6
Ovarian Cancer	0.1	0.2	0.7	-0.1	0.3	-0.4	0.0	0.8	0.1
Prostate Cancer	1.5	2.0	3.6	-1.9	1.4	1.7	1.6	1.0	0.6
Age at First Birth	3.3	4.7	8.7	2.2	-1.8	-1.3	-1.7	-2.6	-2.9
Bipolar Disorder (2011)	1.4	1.3	2.4	-1.1	1.0	0.0	1.6	1.5	1.1
Body Mass Index (BMI) (2010)	0.7	1.0	2.0	-1.4	0.7	-0.4	1.1	0.9	1.1
Coronary Artery Disease (CAD)	2.0	2.4	3.9	2.0	-1.7	-0.9	-1.6	-1.3	-1.7
Crohns Disease (2012)	0.2	0.3	1.3	-0.3	-0.2	1.2	-0.5	-0.5	-0.4
Mean Putamen Volume	0.4	0.4	1.5	-0.1	-0.1	1.2	-0.1	-0.4	-0.9
Fasting Glucose	5.2	6.3	8.8	-3.0	2.5	2.0	2.1	2.6	2.8
HbA1C	1.1	1.2	2.4	-0.5	1.1	0.5	1.2	1.4	1.5
HDL Cholesterol	0.1	0.1	0.3	0.6	0.2	-0.2	0.0	0.1	0.3
LDL Cholesterol	1.6	2.6	8.1	-1.4	1.1	2.8	1.4	1.2	0.9
Lupus	1.7	2.6	3.0	1.7	-1.7	-1.6	-1.4	-1.7	-1.6
Neuroticism (2016)	2.4	3.5	6.4	0.8	-2.5	-1.2	-2.5	-1.2	-2.1
Primary Biliary Cirrhosis	0.3	0.5	1.2	0.9	-0.6	-0.6	-0.4	-0.1	-1.1
Rheumatoid Arthritis	0.8	1.1	2.3	1.1	-0.7	-1.5	-0.7	-1.3	-0.8
Schizophrenia (2014)	0.4	0.8	2.1	-1.5	0.8	0.0	0.9	0.4	1.0
Triglycerides	0.2	0.3	0.9	-0.9	-0.6	0.6	-0.6	-0.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.3	0.4	-0.3	-1.5	-0.4	-0.8	-0.3
Ulcerative Colitis	0.1	0.1	0.4	0.1	0.0	-0.4	0.6	0.5	0.1
Blood Eosinophil Count	0.1	0.6	1.3	-0.9	0.4	1.1	0.5	0.6	1.0
Blood Platelet Count	0.1	1.3	2.8	0.5	-1.5	-0.7	-1.7	-1.1	-1.1
Blood Red Count	0.4	4.0	6.4	-0.2	2.5	0.8	2.4	2.5	2.3
Blood White Count	0.1	0.7	1.9	-0.2	-1.4	-0.5	-1.1	-0.8	-0.2
Heel T-Score	0.8	6.0	12.9	0.2	2.8	0.8	2.5	3.6	2.8
BMI	0.3	1.9	6.9	2.6	-0.9	1.4	-0.8	-0.2	-0.9
Height	0.5	10.3	29.8	-1.8	2.9	5.5	1.9	4.1	-0.0
Waist Hip Ratio (WHR)	0.5	2.1	3.5	0.8	-1.6	-1.3	-1.5	-1.3	-1.9
Systolic Blood Pressure	1.4	7.2	11.0	3.0	-2.6	-3.3	-2.3	-1.9	-2.8
Smoking Status	0.2	0.5	1.1	0.1	-0.4	0.7	-0.6	-1.0	-1.0
Allergy or Eczema	0.4	1.1	2.2	-0.1	-1.3	-0.2	-1.3	-1.5	-1.0
Cardiovascular Disease	1.2	3.9	5.1	2.1	-2.3	-1.1	-2.0	-2.1	-1.9
Hypothyroidism (self reported)	0.5	1.1	4.1	-0.1	0.8	2.0	0.7	1.2	0.4
Respiratory disease	1.6	3.5	5.7	2.4	-1.8	-1.6	-1.8	-2.0	-1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.7	-0.2	0.9	1.3	0.1	0.0	-0.0
Lung FEV1/FVC ratio	0.7	3.4	7.1	1.3	-2.7	0.4	-1.6	-1.8	-2.3
Lung FVC	1.0	5.2	8.7	-2.9	3.0	0.7	2.1	1.9	2.3
Neuroticism	0.5	1.1	4.3	0.0	-0.7	-2.1	-0.6	-1.2	-0.1
Chronotype (morning person)	0.0	0.1	0.1	-0.2	0.4	0.2	0.4	0.3	0.2
Hair Pigment	0.1	2.4	4.2	2.0	-1.5	0.6	-1.2	-2.0	-1.5
Tanning	0.1	1.6	2.5	-0.7	1.6	1.0	1.4	1.4	1.4
Hand grip strength (left)	0.3	0.8	3.7	0.1	0.2	1.9	0.6	0.9	0.2
Number of treatments/medications taken	0.2	0.3	0.7	0.6	-0.4	-0.3	0.1	-0.8	-0.7
Average weekly spirits intake	0.5	0.7	1.1	0.7	-0.9	-1.0	-0.6	-0.7	-0.8
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.5	-0.0	-0.6	0.3	-0.0	0.6
Frequency of depressed mood in last 2 weeks	1.3	1.9	5.5	0.3	-1.5	-2.3	-1.5	-0.8	-0.7
Hearing difficulty/problems: Yes	0.6	0.9	2.5	-1.6	0.9	1.2	0.3	0.6	0.4
Relative age of first facial hair	0.2	0.3	0.5	-0.7	0.7	-0.5	0.7	0.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.8	0.8	-1.4	0.4	-1.7	-0.7	-1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.3	0.3	-0.7	-1.3	-1.2	-1.8	-0.3
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	0.6	-1.2	-0.3	-1.4	-1.3	-0.6
Systolic blood pressure, automated reading	0.5	1.6	2.9	1.7	-1.2	-1.6	-1.1	-0.9	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.6	0.5	0.6	0.8	0.7	0.3	0.6
Angina	0.5	0.6	2.5	1.6	-0.5	0.4	-0.1	-0.0	-0.9
Medication for hormone replacement therapy	2.0	2.2	3.7	1.2	-1.5	-1.1	-1.9	-1.4	-1.6
Vitamin and mineral supplements	0.2	0.3	0.9	0.4	0.3	-0.6	0.1	-0.9	0.1
Supplements: Zinc	0.9	1.0	2.2	-0.4	1.0	1.3	0.9	1.5	0.6
Medication: Co-codamol	0.4	0.4	1.0	0.5	-1.0	-0.5	-0.7	-0.4	-0.6
Medication: Metformin	0.7	1.0	2.1	-0.4	1.3	1.5	0.7	1.0	0.5
Diabetes (father)	0.4	0.4	1.6	0.2	-0.1	1.3	-0.1	-0.1	-1.0
Diabetes (mother)	0.8	1.1	2.3	-0.2	1.0	0.5	1.3	1.1	1.5
Severe depression (siblings)	0.2	0.2	0.5	0.4	-0.3	-0.0	-0.7	0.7	-0.5
Pack years adult smoking proportion	2.6	3.9	4.7	2.1	-2.1	-2.1	-1.7	-1.6	-2.2
Impedance of leg (right)	0.5	2.3	10.6	-0.2	-0.5	-3.3	-1.0	-1.1	-0.7
Leg fat-free mass (left)	0.6	3.3	16.6	0.7	0.3	4.1	0.3	1.6	-0.5
Trunk fat percentage	0.9	3.7	6.2	2.5	-2.0	0.7	-2.2	-1.0	-2.4
Hand grip strength (right)	0.1	0.3	1.5	-0.1	-0.1	1.2	-0.1	0.3	-0.7
Townsend deprivation index at recruitment	0.2	0.3	1.3	0.2	0.0	-1.2	0.5	0.3	0.6
Current tobacco smoking	0.3	0.6	2.6	-0.4	0.0	-1.6	0.3	-0.7	0.2
Average weekly fortified wine intake	0.9	1.1	1.5	1.2	-0.9	-0.9	-1.1	-0.8	-1.2
Maternal smoking around birth	0.1	0.1	0.1	-0.4	0.4	0.3	0.4	0.2	0.3
Fed-up feelings	1.0	1.8	6.5	-0.6	-0.6	-2.5	-0.6	-1.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	6.7	-1.0	-1.0	-2.6	-1.0	-0.9	-0.6
Relative age voice broke	0.1	0.2	0.4	0.4	-0.5	-0.2	-0.3	-0.2	-0.7
Taking other prescription medications	1.3	2.0	2.6	1.3	-1.5	-1.0	-1.6	-1.4	-1.6
Age when periods started (menarche)	0.8	1.8	3.6	-1.9	-1.0	-1.1	-0.7	-1.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.0	-0.1	-0.5	-0.6	-0.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.6	13.3	-0.8	3.2	1.1	2.8	2.5	3.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.4	0.2	-0.6	0.6	0.2	0.5
Qualifications: CSEs or equivalent	0.6	0.8	1.6	-0.6	0.8	0.3	1.3	1.2	0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.1	0.6	-0.9	0.1	-0.7	-0.8	-1.1
High blood pressure	0.4	1.1	1.8	0.8	-1.2	-1.2	-0.8	-1.3	-0.8
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.4	-0.5	-0.2	-0.5	-0.7	-0.5
Multivitamins +/- minerals	0.3	0.4	0.9	0.4	-0.8	0.2	-0.7	0.6	-1.0
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.5	-0.3	-1.2	0.2	-0.8	0.7
Supplements: Glucosamine	2.1	2.7	4.5	-2.1	1.8	1.3	1.6	1.4	1.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	-0.2	0.6	-1.1	0.9	1.2	0.7
Medication: Atenolol	0.2	0.2	0.4	0.5	-0.6	-0.6	0.0	-0.3	-0.7
Medication: Levothyroxine sodium	1.3	2.2	6.3	-0.9	1.4	2.5	1.3	1.2	0.9
Sitting height	0.2	1.5	4.6	-0.3	0.8	2.1	0.7	1.8	-0.0
Chronic bronchitis/emphysema (father)	0.6	0.8	2.9	-0.8	-0.2	1.7	-0.2	0.1	1.0
High blood pressure (mother)	2.5	3.6	6.3	1.5	-2.5	-0.5	-2.0	-2.0	-2.2
Body mass index (BMI)	0.4	1.5	3.8	1.9	-1.2	1.3	-0.9	-0.7	-1.0
Impedance of leg (left)	0.5	2.2	11.7	-0.3	-0.3	-3.4	-0.5	-0.9	-0.6
Leg predicted mass (left)	0.6	3.4	16.8	0.7	0.3	4.1	0.3	1.6	-0.5
Trunk fat mass	0.7	2.8	4.5	2.1	-1.4	1.9	-1.6	-0.3	-2.0
Waist circumference	0.5	1.8	3.1	1.8	-1.2	1.5	-1.0	-0.2	-1.6
Number of incorrect matches in round	1.1	1.8	3.4	-1.2	1.8	0.9	1.5	1.4	1.0
Past tobacco smoking	0.5	0.9	3.1	-0.0	0.6	-1.8	1.0	0.2	0.9
Alcohol usually taken with meals	1.3	2.0	10.0	-0.1	0.6	3.2	0.4	1.2	0.5
Nervous feelings	0.0	0.1	0.3	-0.1	0.0	-0.5	-0.3	-0.0	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-0.9	0.4	-1.1	0.2	1.0	0.8
Hearing difficulty/problems with background noise	0.2	0.4	0.6	-0.1	-0.7	0.7	-0.7	-0.4	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.6	-0.5	0.0	1.3	0.2	-0.3	0.4
Had menopause	0.2	0.2	0.6	0.3	-0.1	-0.7	-0.3	-0.8	-0.3
Had other major operations	0.1	0.2	0.5	-0.4	0.1	-0.3	0.7	0.4	0.5
Forced vital capacity (FVC)	0.5	2.0	4.4	-1.1	1.7	1.4	1.2	2.1	0.4
Heel bone mineral density (BMD) T-score, automated (right)	3.9	8.8	17.3	-1.0	3.7	1.5	3.1	3.1	4.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	-0.1	0.3	-0.4	0.4	-0.1
Qualifications: None of the above	0.4	0.8	1.3	-1.1	0.9	-0.7	1.0	-0.0	1.0
Financial difficulties in last 2 years	1.0	1.4	2.2	-0.6	-1.5	-0.1	-1.5	-1.5	-1.1
Mouth/teeth dental problems	3.7	5.7	8.7	-0.1	2.7	2.6	2.2	3.0	2.6
Heart attack	8.2	10.4	18.3	4.3	-3.5	-1.7	-2.9	-3.1	-3.4
Allergy	0.3	0.7	1.1	0.0	1.1	0.5	1.0	0.7	1.1
Pain all over the body in last month	0.6	0.7	1.2	-1.0	1.0	0.2	0.8	1.1	0.3
Diabetes (self-reported)	0.2	0.3	1.0	0.3	0.8	1.0	0.1	0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	0.8	-0.7	-1.7	-0.4	-1.7	-0.5
Medication: Ramipril	2.6	3.4	5.0	2.2	-1.7	-1.4	-1.4	-2.1	-1.9
Medication: Simvastatin	0.4	0.6	1.4	0.6	-0.6	1.2	-1.0	-0.7	-0.6
Fluid intelligence score	0.6	1.3	2.0	1.4	-1.2	0.8	-1.1	-1.0	-1.1
Illnesses of siblings	0.1	0.1	0.3	0.1	0.6	-0.3	0.2	0.4	0.5
Neuroticism score	0.5	1.0	4.5	-0.6	-0.5	-2.1	-0.6	-0.6	0.0
Weight	0.4	2.1	8.6	1.4	-0.5	2.9	-0.4	0.6	-1.1
Impedance of arm (right)	0.4	2.1	4.1	0.3	-1.0	-2.0	-1.7	-1.5	-1.5
Arm fat percentage (right)	0.8	3.3	6.6	2.6	-2.0	0.6	-2.1	-1.3	-1.7
Trunk fat-free mass	0.7	4.1	17.6	-0.4	1.1	4.2	1.2	2.0	0.2
Hip circumference	0.6	2.8	8.8	2.1	-0.8	3.0	-0.6	0.6	-1.5
Time employed in main current job	1.0	1.2	3.4	-0.4	-1.0	-1.9	-1.0	-0.8	-0.8
Alcohol intake versus 10 years previously	0.1	0.1	0.5	-0.0	-0.0	-0.7	-0.2	-0.3	-0.0
Father’s age at death	0.1	0.1	0.5	0.1	-0.1	0.7	0.0	0.1	0.5
Worrier / anxious feelings	0.1	0.1	0.7	0.4	0.1	-0.1	-0.2	0.8	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.3	-1.6	-0.4	-2.1	-0.3	-0.7	0.7
Falls in the last year	0.2	0.2	0.8	-0.9	0.1	-0.1	0.4	-0.5	-0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.8	0.2	-0.8	0.1	0.4	0.4
Number of live births	0.5	0.7	1.4	0.1	-1.2	0.8	-1.1	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-1.1	1.0	1.3	0.8	1.5	0.0
Pulse rate	1.1	1.8	3.7	-0.2	-1.4	-1.9	-1.3	-1.7	-0.9
Happiness	0.3	0.3	0.8	0.5	-0.9	0.4	-0.6	0.2	-0.6
Noisy workplace	3.6	4.5	7.0	-2.6	2.2	0.6	2.6	1.7	2.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.9	1.2	-1.0	1.4	-0.4	0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.6	6.6	2.6	-2.2	-0.2	-2.1	-1.2	-2.1
Mouth/teeth dental problems: Dentures	1.5	2.5	4.8	0.9	-1.6	-2.2	-0.8	-1.8	-1.7
Asthma	2.3	4.6	5.2	2.1	-2.1	-2.2	-2.0	-2.2	-2.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	4.1	0.8	-2.0	0.2	-1.6	-0.2	-1.4
Medication: Cholesterol lowering	0.6	0.9	2.1	1.4	-0.3	1.1	-0.6	-0.7	-1.0
Depression (self-reported)	0.5	0.6	1.8	-1.3	0.2	-0.1	0.4	0.5	1.2
Medication: Lansoprazole	1.2	1.4	4.8	1.2	-0.7	-2.2	-0.5	-1.0	-0.6
Prospective memory result	5.3	6.5	10.7	-2.8	3.1	0.6	3.3	2.1	2.5
Lung cancer (father)	0.5	0.6	2.2	-0.4	-0.4	-1.5	-0.2	-0.5	0.9
Illnesses of mother	0.9	1.1	2.5	-1.0	0.9	0.3	0.8	1.3	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.5	-0.9	0.9	0.7	0.7	1.2	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.9	-1.0	-0.1	-0.1	-0.2	-0.3	0.3
Impedance of arm (left)	0.4	2.0	4.3	0.3	-1.0	-2.1	-1.6	-1.4	-1.4
Arm fat mass (right)	0.5	2.2	4.8	2.2	-1.4	1.6	-1.3	-0.5	-1.4
Trunk predicted mass	0.7	4.0	17.9	-0.4	1.1	4.2	1.1	1.9	0.2
Standing height	0.5	4.9	13.8	-1.2	1.8	3.7	1.3	3.0	-0.2
Length of working week for main job	0.2	0.2	0.3	0.6	-0.4	-0.0	-0.5	0.1	-0.5
Exposure to tobacco smoke at home	0.5	0.6	1.6	0.1	0.8	0.5	1.3	0.7	0.8
Breastfed as a baby	0.5	0.6	1.3	1.1	-0.7	0.2	-0.9	0.2	-1.0
Tense / ‘highly strung’	0.2	0.4	1.6	-0.4	0.3	-1.2	0.3	0.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.8	0.3	-1.4	-2.0	-1.8	-0.9	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	0.9	-0.8	-0.9	-0.4	-1.4	-0.4
Birth weight of first child	0.8	1.5	7.6	-0.3	0.4	2.7	0.2	0.6	0.9
Peak expiratory flow (PEF)	0.5	1.1	2.8	-0.8	0.9	1.4	0.6	1.7	0.3
Pulse wave reflection index	0.2	0.2	0.7	0.2	0.4	0.8	0.1	0.5	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.4	0.1	-0.0	0.4	0.4	0.2
Loud music exposure frequency	1.1	1.2	3.4	-1.0	0.8	-1.9	1.0	0.4	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.2	1.1	-1.0	-0.7	-0.7	-0.7	-0.4
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	6.2	0.3	-2.5	-0.7	-2.4	-2.1	-2.5
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.1	0.0	0.7	0.0	0.3	-0.4
Medication: Paracetamol	0.1	0.1	0.4	-0.1	-0.0	-0.6	0.5	0.2	0.4
Headache pain in last month	0.3	0.5	2.2	-0.5	0.0	-1.5	0.2	0.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.5	-1.6	0.8	-0.5	1.0	1.1	1.1
Glaucoma (self-reported)	0.2	0.2	0.6	-0.8	0.1	-0.5	-0.2	-0.6	-0.2
Gout (self-reported)	0.3	0.4	0.9	0.3	0.8	0.1	1.0	0.7	0.7
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	8.7	-1.0	1.5	2.9	1.3	1.7	1.0
Medication: Amlodipine	1.3	1.8	4.0	0.2	-1.3	-1.3	-1.2	-2.0	-1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.9	1.0	0.2	-1.7	0.4	-1.2	0.1
Birth weight	0.4	0.8	1.9	1.1	-0.9	1.4	-0.6	0.1	-0.6
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.9	-2.0	1.6	0.5	1.2	1.2	1.3
High blood pressure (siblings)	0.4	0.5	1.1	0.2	-1.0	0.2	-0.9	-0.4	-1.0
Forced vital capacity (FVC), Best measure	0.5	1.8	3.3	-1.2	1.8	0.9	1.4	1.8	0.4
Body fat percentage	0.9	3.4	6.4	2.5	-1.9	0.7	-2.0	-1.1	-2.1
Leg fat percentage (right)	0.7	2.4	4.7	2.2	-1.5	0.6	-1.6	-1.1	-1.7
Arm fat-free mass (right)	0.6	3.0	12.0	-0.0	0.8	3.5	1.0	2.1	0.2
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.6	-0.3	-0.5	-0.2	-0.7	-0.2
Comparative body size at age 10	0.4	1.0	3.7	1.1	0.1	1.9	0.4	0.4	1.0
Number of full brothers	0.9	1.1	2.8	-0.9	0.9	0.8	1.7	0.6	1.1
Worry too long after embarrassment	0.6	1.1	2.6	-0.3	-1.2	-1.6	-1.2	-0.8	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	5.6	-2.4	0.9	-0.4	0.1	1.2	1.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.8	-0.2	-0.9	-0.0	-0.5	0.4
Number of children fathered	0.2	0.3	0.8	0.0	0.5	-0.8	0.0	-0.9	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.4	-0.4	0.8	-0.6	0.0	-0.6
Age at first live birth	0.2	0.4	1.8	0.2	0.4	1.3	0.2	0.3	-0.6
Pulse wave peak to peak time	0.2	0.2	0.4	0.6	0.3	0.5	0.4	0.6	-0.3
Health satisfaction	0.3	0.4	1.1	0.2	-1.0	0.4	-0.6	-0.9	-0.1
Shortness of breath walking on level ground	0.9	1.1	3.5	0.8	-1.0	-1.9	-0.7	-0.9	-0.0
Qualifications: College or University degree	0.2	0.6	2.0	-0.6	0.5	1.4	-0.1	0.9	0.0
Eye problems/disorders: None of the above	0.9	1.1	2.1	1.5	-0.8	0.0	-1.0	-1.0	-1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.3	-0.4	-0.4	-1.1	-0.3	-0.8	-0.2
Emphysema/chronic bronchitis	0.3	0.3	1.3	0.2	-0.4	-1.1	-0.3	-0.3	0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	0.5	-0.8	-0.7	-1.3	-1.2	-0.4
Neck or shoulder pain in last month	1.6	2.2	12.0	-0.3	-0.5	-3.5	-0.2	-0.8	0.5
Medication: Blood pressure	0.4	0.6	1.8	0.7	-0.6	0.0	-0.8	-1.3	-0.7
Angina (self-reported)	0.5	0.7	2.7	1.6	-0.6	0.5	-0.2	-0.0	-0.9
Migraine (self-reported)	2.6	3.3	4.6	2.1	-1.9	-0.5	-1.9	-2.0	-1.9
Medication: Ibuprofen	0.7	0.8	2.0	0.6	-1.4	0.2	-1.1	-0.1	-1.3
Medication: Allopurinol	0.3	0.4	1.1	-0.2	0.8	0.2	0.8	1.0	0.4
Medication: Omeprazole	0.2	0.3	0.5	0.4	0.4	0.2	0.7	0.7	0.5
Medication: Seretide 50 evohaler	0.8	0.9	4.6	-0.1	-0.3	-2.1	-0.2	-0.8	0.4
Mean time to correctly identify matches	0.1	0.1	0.4	0.0	-0.1	-0.6	-0.0	-0.6	-0.3
Heart disease (mother)	3.5	4.3	6.9	2.5	-2.0	-0.5	-1.9	-2.2	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	-0.8	-0.2	-1.3	-0.1	-0.7	-0.1
Whole body fat mass	0.5	2.3	4.2	1.9	-1.3	2.0	-1.3	-0.3	-1.6
Leg fat mass (right)	0.5	1.8	3.6	1.9	-1.0	1.9	-1.1	-0.3	-1.3
Arm predicted mass (right)	0.7	3.5	14.3	-0.0	0.9	3.8	1.1	2.1	0.2
Pulse rate, automated reading	0.1	0.2	0.5	-0.7	-0.4	-0.4	-0.3	-0.4	0.6
Alcohol intake frequency.	0.1	0.3	0.9	1.0	-0.0	-0.4	0.5	0.6	0.2
Comparative height size at age 10	0.5	2.6	6.7	-1.4	1.4	2.6	0.7	2.2	0.3
Number of full sisters	0.1	0.1	0.2	-0.1	-0.4	0.1	-0.4	-0.4	-0.5
Suffer from ‘nerves’	0.4	0.7	2.8	-0.3	-0.6	-1.7	-0.6	-0.7	0.3
Overall health rating	0.5	1.1	2.4	1.1	-1.1	-1.2	-0.5	-1.5	-0.1
Chest pain or discomfort	0.9	1.2	3.8	-2.0	0.4	-1.5	0.4	0.1	1.0
Had major operations	0.2	0.2	0.3	0.3	-0.5	-0.6	-0.5	-0.5	0.4
Age at last live birth	0.5	0.7	1.8	-0.9	0.8	1.3	0.8	0.6	-0.0
Family relationship satisfaction	0.4	0.5	1.1	0.7	-1.0	-0.5	-0.6	-1.0	-0.4
Leg pain on walking	0.3	0.4	1.2	-1.1	-0.2	-0.5	-0.2	-0.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	-0.3	0.6	0.6	0.8	0.4	0.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.8	-1.7	1.3	1.4	1.1	1.1	0.9
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	6.0	-1.1	2.1	1.1	2.1	1.8	2.5
Medication: Aspirin	0.2	0.3	1.0	0.1	1.0	0.2	0.7	0.2	0.2
Supplements: Vitamin C	0.2	0.2	0.4	-0.3	0.5	0.4	0.2	0.6	0.5
Knee pain experienced in last month	0.6	0.9	3.5	-1.3	-0.0	1.9	-0.0	-0.4	0.2
Hypertension (Self-reported)	0.2	0.6	0.9	0.8	-0.9	-0.7	-0.5	-1.0	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	-1.0	-0.2	-0.5	0.1	-0.3	0.0
Illnesses of father: Heart disease	0.8	1.2	2.3	0.0	-1.0	-0.6	-1.4	-1.2	-1.5
Illnesses of siblings: Diabetes	0.4	0.5	2.6	1.6	-0.0	0.3	0.0	0.3	-0.6
Smoking status: Previous	0.8	1.2	2.6	0.6	-0.9	1.6	-1.3	-0.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.0	0.2	0.2	1.1	0.3	1.4	-0.8
Whole body fat-free mass	0.6	3.6	16.7	0.0	0.8	4.1	0.8	1.9	-0.1
Leg fat-free mass (right)	0.6	3.3	15.4	0.6	0.5	3.9	0.5	1.8	-0.4
Arm fat percentage (left)	1.0	3.9	7.7	2.8	-2.1	0.5	-2.2	-1.4	-2.0
Average weekly red wine intake	0.1	0.1	0.4	-0.6	0.3	-0.3	0.2	0.3	0.2
Handedness (chirality/laterality): Left-handed	2.9	3.5	6.5	-1.3	1.7	1.9	2.1	1.3	2.5
Mood swings	2.2	4.0	7.8	2.1	-1.6	-2.8	-2.0	-1.8	-1.5
Loneliness, isolation	1.0	1.3	3.1	0.5	-1.0	-1.8	-0.9	-1.6	-0.3
Long-standing illness, disability or infirmity	1.9	2.9	4.2	1.3	-2.0	-0.7	-1.7	-2.0	-2.0
Ever had bowel cancer screening	3.4	4.0	7.4	-1.9	2.3	0.2	1.8	2.1	2.7
Diabetes diagnosed by doctor	0.4	0.7	1.6	-0.6	1.3	1.3	0.6	0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	0.5	-1.1	0.1	-1.0	-0.5	-0.5
Friendships satisfaction	1.4	1.7	3.2	0.5	-1.6	-1.7	-0.8	-1.8	-1.0
Qualifications: nursing, teaching	0.6	1.0	3.7	-0.1	-0.7	1.9	-0.8	-0.4	-0.8
Commuting to job workplace: Walk	0.1	0.1	0.4	-0.2	-0.5	0.6	0.1	0.2	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.6	0.2	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	-0.5	-0.4	0.7	-0.2	-0.6	-0.4
Medication for cholesterol	0.2	0.4	0.7	-0.6	0.9	0.6	0.5	0.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.4	0.6	0.6	0.5	0.9	0.6
Back pain experienced in last month	0.5	0.7	1.2	0.4	-1.1	-0.5	-0.9	-1.1	-1.0
Mineral and other dietary supplements	0.3	0.3	1.5	1.2	-0.2	-0.0	0.1	0.2	-0.7
Breast cancer (self-reported)	6.4	7.6	11.5	-2.7	2.9	2.2	2.6	2.7	3.4
Asthma (self-reported)	2.1	4.1	4.8	2.2	-1.9	-2.2	-1.8	-2.0	-2.1
Osteoporosis (self-reported)	0.8	0.9	2.4	0.6	-0.7	1.5	-0.1	-1.3	-0.8
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.2	0.7	0.4	0.3	0.5	0.9
Medication: Aspirin	0.4	0.6	1.9	-0.2	1.4	0.3	1.0	0.5	0.3
Medication: Gliclazide	1.5	1.7	3.3	-1.8	1.7	0.5	1.4	0.6	1.2
Illnesses of father: None of the above (group 1)	1.2	1.5	2.5	0.0	1.4	-0.4	1.6	1.6	1.4
Smoking status: Current	0.3	0.4	1.6	-0.6	0.2	-1.3	0.4	-0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.8	-1.3	1.2	0.7	1.1	1.0	1.1
Whole body water mass	0.7	3.8	17.6	0.0	0.8	4.2	0.9	2.0	-0.0
Leg predicted mass (right)	0.6	3.3	15.5	0.6	0.4	3.9	0.5	1.8	-0.4
Arm fat mass (left)	0.6	2.6	5.9	2.4	-1.4	1.6	-1.5	-0.5	-1.7
Number of self-reported non-cancer illnesses	1.1	1.9	2.7	1.0	-1.6	-1.6	-1.3	-1.6	-0.8
Average weekly champagne plus white wine intake	0.7	1.0	4.0	-0.4	-0.3	2.0	-0.4	-0.3	-1.2
Miserableness	0.4	0.7	1.5	-1.2	0.6	-1.1	0.2	0.8	0.7
Guilty feelings	0.5	0.8	2.6	-0.2	-0.7	-1.6	-0.3	-1.0	0.6
Wears glasses or contact lenses	0.3	0.4	0.9	-0.9	0.4	0.9	0.1	0.7	0.2
Ever taken oral contraceptive pill	3.3	3.6	5.8	1.2	-1.8	-1.3	-2.1	-2.4	-2.3
Hearing aid user	0.3	0.4	0.7	-0.8	0.7	0.1	0.6	0.7	0.5
Mother’s age at death	0.1	0.1	0.6	0.7	0.2	-0.0	-0.1	0.0	-0.4
Financial situation satisfaction	1.5	1.8	5.0	0.2	-1.4	-2.2	-0.9	-1.5	-0.8
Tinnitus: Yes, now most or all of the time	3.8	4.4	8.0	-1.2	2.7	0.8	2.8	2.0	2.2
Commuting to job workplace: Public transport	0.3	0.4	2.2	1.5	-0.0	-0.2	0.2	0.1	-0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	-0.9	0.4	-0.6	0.3	-0.7	-0.2
Medication: Blood pressure	0.6	1.1	1.9	0.8	-1.4	-1.1	-0.8	-0.9	-1.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	0.4	-1.0	-0.5	-0.2	-0.8	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	-0.6	-0.5	-0.6	-0.5	-0.6	0.2
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.0	-0.1	0.6	-0.4	-0.6	0.8
Medication: Bendroflumethiazide	1.1	1.7	3.4	0.6	-1.6	-0.7	-0.9	-1.8	-1.7
Medication: Paracetamol	0.1	0.2	0.3	0.6	0.1	-0.5	0.5	0.3	-0.1
Medication: Lisinopril	0.6	0.8	1.3	-0.8	0.5	1.1	0.7	0.8	1.1
Medication: Atorvastatin	0.5	0.6	2.5	1.6	0.0	1.1	-0.0	0.0	-0.4
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.1	-0.1	0.4	-0.3	-0.8	-0.9
Alcohol drinker status: Never	1.6	2.0	3.1	-1.2	1.5	0.5	1.8	1.7	1.3
Ever smoked	0.2	0.4	1.6	-0.1	-0.2	1.2	-0.7	0.3	0.0
Basal metabolic rate	0.5	3.0	14.7	0.6	0.4	3.8	0.4	1.6	-0.4
Leg fat percentage (left)	0.4	1.6	3.6	1.9	-1.2	0.6	-1.1	-0.8	-1.4
Arm fat-free mass (left)	0.6	3.0	13.1	-0.0	0.7	3.6	0.8	1.9	-0.0
Number of operations (self-reported)	0.3	0.5	2.3	-0.4	-0.4	-1.5	-0.1	0.0	0.5
Average weekly beer plus cider intake	0.3	0.4	0.9	-0.5	0.8	-0.3	0.9	0.4	0.4
Irritability	1.0	1.7	5.1	-0.7	-1.0	-2.3	-1.1	-1.3	-0.7
Risk taking	0.2	0.3	0.6	-0.6	0.3	0.5	0.8	-0.3	0.4
Ever had prostate specific antigen (PSA) test	4.3	5.0	8.4	-1.3	2.6	2.2	2.2	1.8	2.9
Fractured/broken bones in last 5 years	1.6	2.0	4.4	0.3	-1.5	0.4	-1.6	-2.1	-1.6
Age started oral contraceptive pill	0.3	0.3	0.8	-0.3	0.5	0.8	0.4	0.0	0.9
Diastolic blood pressure, automated reading	0.1	0.3	1.6	0.2	0.0	-1.2	0.2	-0.1	0.5
Ever depressed for a whole week	2.1	2.6	5.6	1.3	-2.1	-0.9	-2.4	-0.6	-1.6
Unable to work because of sickness or disability	0.5	0.6	1.1	-0.1	-1.0	-1.1	-0.5	-1.0	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.3	0.2	0.4	0.2	0.5	0.2
Myopia	1.1	1.6	5.0	-0.0	1.2	2.2	1.0	0.7	1.4
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.5	-1.3	1.6	1.4	1.1	1.9	1.3
Cholesterol lowering medication	0.5	0.7	1.5	0.4	-1.0	0.8	-0.9	-1.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.7	-0.2	-0.8	0.1	-0.0	-0.2
Pain experienced in last month	0.5	0.8	1.9	0.1	0.8	1.4	1.0	0.8	0.7
Supplements: Calcium	0.6	0.6	2.2	0.2	0.5	1.5	0.4	0.8	0.7
Basal cell carcinoma (self-reported)	3.4	4.0	7.5	-2.1	2.7	-0.1	2.5	1.9	1.5
Heart attack/myocardial infarction (self-reported)	8.0	10.3	18.2	4.3	-3.4	-1.9	-2.9	-3.1	-3.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	-0.0	0.1	0.8	0.1	0.3	-0.4
Heart disease (siblings)	1.2	1.4	3.2	-0.6	-1.4	-0.0	-1.2	-1.8	-1.2
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.1	0.3	-0.3	0.7	0.7	0.8
Pack years of smoking	2.3	3.3	4.4	1.9	-1.8	-2.1	-1.4	-1.7	-2.0
Impedance of whole body	0.5	2.7	9.9	0.2	-0.9	-3.1	-1.4	-1.2	-1.4
Leg fat mass (left)	0.4	1.6	3.4	1.8	-0.9	1.9	-0.8	-0.1	-1.2
Arm predicted mass (left)	0.5	2.8	12.7	0.2	0.6	3.6	0.7	1.7	-0.1