Hub : Genes

KXD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.1760	0.0640	0.00640	0.038	NA	-0.006	NA	0.019	1.7e-02	NA	6.0e-01	NA	6.5e-02
2	GTEx	Testis	0.1900	0.0610	0.00063	0.206	NA	0.187	NA	0.172	1.6e-09	NA	1.1e-08	NA	4.6e-08
3	ROSMAP	Brain Pre-frontal Cortex	0.0548	0.0197	0.00041	0.043	0.025	0.032	0.029	0.036	2.6e-06	0.00032	4.7e-05	0.00011	1.8e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.8	0.0	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.4	0.3	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.3	0.3	1.0	-1.2
Depression (Nagel 2018)	0.6	0.8	2.3	1.5	-0.3	0.3
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	-0.1	-0.1	0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.7	0.4	-0.4
Schizophrenia (2018)	0.1	0.1	0.3	0.1	0.3	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-1.1	-0.4	0.2
Worry (Nagel 2018)	0.1	0.2	0.5	0.7	0.2	-0.2
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	-0.6	0.1	-0.2
Alzheimer’s Disease (in father)	2.4	2.6	3.2	-1.3	1.8	-1.7
Alzheimer’s Disease (including proxy)	0.8	1.1	1.6	-1.3	0.9	-1.0
Crohns Disease (2017)	0.7	1.5	1.9	0.7	-1.4	1.4
Irritable Bowel Disease (IBD)	0.3	0.6	0.8	0.7	-0.9	0.8
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.1	0.0	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.6	1.1	3.3	1.8	-0.2	-0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	-0.3	1.0	-0.8
Breast Cancer	0.4	1.0	2.7	-1.6	0.4	-0.3
Ovarian Cancer	0.0	0.0	0.1	-0.2	-0.2	0.3
Prostate Cancer	0.4	0.6	0.7	0.8	0.6	-0.8
Age at First Birth	0.7	1.1	1.6	-0.6	1.3	-1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.0	0.1	-0.1
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.0	1.6	2.3	0.6	-1.5	1.5
Mean Putamen Volume	2.9	3.3	3.8	2.0	-1.6	1.9
Fasting Glucose	0.3	0.3	0.4	-0.6	0.3	-0.7
HbA1C	0.4	0.5	0.7	-0.4	-0.7	0.8
HDL Cholesterol	3.8	6.4	8.0	-2.2	2.8	-2.6
LDL Cholesterol	0.3	0.5	1.2	-1.1	-0.3	0.3
Lupus	0.1	0.1	0.1	0.3	0.4	-0.2
Neuroticism (2016)	0.2	0.3	0.5	-0.1	0.6	-0.7
Primary Biliary Cirrhosis	0.6	0.8	1.1	1.1	0.9	-0.8
Rheumatoid Arthritis	0.5	0.7	2.2	1.5	-0.2	0.1
Schizophrenia (2014)	0.1	0.2	0.3	-0.3	0.4	-0.6
Triglycerides	0.7	1.1	2.0	-0.2	-1.4	1.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.5	0.9	-0.1	0.8	-1.0
Blood Eosinophil Count	0.1	0.8	1.2	0.8	-1.1	0.8
Blood Platelet Count	0.1	1.6	2.0	1.3	-1.4	1.1
Blood Red Count	1.2	11.3	16.0	-1.7	4.0	-3.9
Blood White Count	0.7	4.9	5.8	2.0	-2.4	2.2
Heel T-Score	0.5	4.2	6.3	-0.9	2.5	-2.3
BMI	2.2	12.8	27.1	5.2	-2.2	2.5
Height	0.3	5.1	8.6	-2.9	1.7	-2.0
Waist Hip Ratio (WHR)	0.1	0.6	1.3	-1.1	-0.6	0.4
Systolic Blood Pressure	0.6	3.1	4.8	-0.6	2.2	-2.1
Smoking Status	0.6	1.5	3.0	1.7	-1.0	0.8
Allergy or Eczema	0.1	0.3	0.7	-0.8	0.3	-0.3
Cardiovascular Disease	1.8	6.1	10.7	3.3	-2.0	1.9
Hypothyroidism (self reported)	1.0	2.3	3.3	1.8	-1.3	1.4
Respiratory disease	0.4	0.8	1.2	-0.7	0.9	-1.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.9	2.0	-1.0	0.9
Lung FEV1/FVC ratio	0.2	1.0	1.5	-0.6	1.2	-1.1
Lung FVC	0.5	2.6	4.3	-0.1	2.1	-1.9
Neuroticism	0.2	0.5	0.6	0.6	0.6	-0.8
Chronotype (morning person)	0.4	0.8	1.1	0.7	1.1	-0.9
Hair Pigment	0.0	0.6	0.7	-0.6	0.8	-0.8
Tanning	0.4	4.7	6.0	2.5	-2.2	1.9
Hand grip strength (left)	0.5	1.2	3.4	-1.9	0.3	-0.3
Number of treatments/medications taken	1.3	2.3	2.5	1.6	1.4	-1.5
Average weekly spirits intake	3.7	4.6	7.2	2.7	-1.9	1.7
Sensitivity / hurt feelings	0.2	0.4	0.4	0.7	-0.7	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	1.4	0.5	-0.4
Hearing difficulty/problems: Yes	0.3	0.4	0.7	0.1	-0.7	0.9
Relative age of first facial hair	0.1	0.2	0.3	-0.2	-0.6	0.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	2.4	-1.5	1.6	-1.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.7	0.1	-0.3
Ever had hysterectomy (womb removed)	1.8	2.1	3.0	0.9	-1.7	1.6
Systolic blood pressure, automated reading	0.3	0.9	1.3	1.1	0.9	-0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.1	0.4	1.1	-1.0
Angina	0.0	0.1	0.2	-0.1	-0.1	0.4
Medication for hormone replacement therapy	1.5	1.6	3.7	-1.9	0.8	-0.7
Vitamin and mineral supplements	0.9	1.2	1.6	-0.9	-1.2	1.1
Supplements: Zinc	0.8	0.8	1.2	-0.4	-1.1	1.1
Medication: Co-codamol	0.2	0.2	0.4	0.1	-0.7	0.5
Medication: Metformin	1.5	2.2	2.8	1.7	-1.4	1.3
Diabetes (father)	1.5	1.8	2.0	1.3	1.4	-1.4
Diabetes (mother)	0.7	0.9	1.9	1.4	-0.6	0.8
Severe depression (siblings)	0.2	0.2	0.7	-0.8	0.1	-0.1
Pack years adult smoking proportion	1.8	2.8	6.9	2.6	-0.9	0.9
Impedance of leg (right)	0.3	1.4	2.2	-1.5	-1.0	0.9
Leg fat-free mass (left)	0.3	1.4	1.4	1.2	1.2	-1.2
Trunk fat percentage	0.6	2.4	6.7	2.6	-0.3	0.6
Hand grip strength (right)	1.3	3.7	10.8	-3.3	0.4	-0.3
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.2	0.1	-0.0
Current tobacco smoking	0.4	0.7	1.9	1.4	0.2	-0.3
Average weekly fortified wine intake	0.0	0.1	0.1	-0.2	0.3	-0.2
Maternal smoking around birth	0.1	0.2	0.3	0.2	-0.5	0.5
Fed-up feelings	0.6	1.1	1.5	0.6	1.2	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	1.5	-0.6	0.5
Relative age voice broke	0.6	0.9	2.8	-1.7	-0.1	0.1
Taking other prescription medications	0.6	0.9	1.3	0.6	1.0	-1.1
Age when periods started (menarche)	1.9	4.5	13.5	-3.7	-0.3	0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.7	1.3	-1.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	3.2	7.3	9.4	-2.1	3.1	-2.9
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	1.8	-1.4	1.2	-1.1
Qualifications: CSEs or equivalent	0.7	0.9	1.1	1.0	0.9	-0.9
Serious illness, injury or assault to yourself	1.5	1.8	2.8	-0.6	1.5	-1.7
High blood pressure	1.4	3.9	6.6	2.6	-1.7	1.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.5	-0.1	0.7	-0.7
Multivitamins +/- minerals	1.8	2.3	3.6	-0.2	1.9	-1.8
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	0.5	-0.5
Supplements: Glucosamine	0.5	0.7	1.0	0.8	-0.7	1.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	-0.1	0.5	-0.5
Medication: Atenolol	0.2	0.2	0.4	0.2	-0.6	0.5
Medication: Levothyroxine sodium	0.5	0.8	0.9	1.0	-0.9	0.9
Sitting height	0.2	1.4	1.6	-1.2	1.1	-1.3
Chronic bronchitis/emphysema (father)	2.2	2.6	3.3	-1.3	1.8	-1.6
High blood pressure (mother)	1.0	1.4	2.8	1.7	0.9	-0.8
Body mass index (BMI)	1.2	5.2	14.9	3.9	-0.5	0.7
Impedance of leg (left)	0.2	1.1	2.6	-1.6	-0.7	0.5
Leg predicted mass (left)	0.3	1.4	1.5	1.2	1.2	-1.2
Trunk fat mass	0.7	3.0	8.8	3.0	-0.1	0.3
Waist circumference	0.7	2.7	7.8	2.8	-0.3	0.5
Number of incorrect matches in round	2.4	4.0	5.6	1.3	-2.4	2.2
Past tobacco smoking	0.4	0.7	0.8	-0.7	0.9	-0.9
Alcohol usually taken with meals	0.1	0.2	0.3	0.6	-0.3	0.4
Nervous feelings	0.0	0.0	0.0	0.0	-0.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	0.7	1.2	-1.1
Hearing difficulty/problems with background noise	0.0	0.0	0.1	-0.2	-0.1	0.2
Hair/balding pattern: Pattern 2	0.8	1.0	1.4	-0.5	1.2	-1.1
Had menopause	1.1	1.3	2.8	-1.7	0.7	-0.8
Had other major operations	0.5	0.7	1.9	1.4	-0.3	0.2
Forced vital capacity (FVC)	0.2	0.8	1.3	-1.1	0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	8.0	-1.2	2.8	-2.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	1.9	-0.0	1.4	-1.4
Qualifications: None of the above	0.3	0.7	1.6	-1.3	-0.6	0.5
Financial difficulties in last 2 years	0.6	0.9	2.6	1.6	0.1	-0.0
Mouth/teeth dental problems	0.2	0.3	0.6	-0.8	0.2	-0.4
Heart attack	1.8	2.3	3.3	0.9	-1.6	1.8
Allergy	0.0	0.1	0.1	-0.1	-0.3	0.3
Pain all over the body in last month	0.7	0.8	0.9	-0.8	1.0	-0.9
Diabetes (self-reported)	2.1	3.2	4.6	2.1	-1.6	1.5
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.4	-1.8	0.8	-1.3
Medication: Ramipril	2.5	3.3	8.1	2.8	-0.7	1.1
Medication: Simvastatin	1.3	1.9	2.1	1.2	-1.4	1.4
Fluid intelligence score	0.1	0.1	0.2	0.2	0.4	-0.3
Illnesses of siblings	0.3	0.4	0.5	0.1	0.7	-0.7
Neuroticism score	0.7	1.5	2.4	0.4	1.4	-1.5
Weight	0.6	3.0	8.9	3.0	0.2	-0.1
Impedance of arm (right)	0.8	3.5	9.8	-3.1	0.6	-0.7
Arm fat percentage (right)	1.0	3.8	10.8	3.3	-0.4	0.6
Trunk fat-free mass	0.3	1.5	2.4	1.6	1.0	-1.1
Hip circumference	0.7	2.9	8.5	2.9	0.2	0.0
Time employed in main current job	3.0	3.5	5.0	0.8	-2.2	2.2
Alcohol intake versus 10 years previously	1.7	2.6	3.6	1.0	1.9	-1.8
Father’s age at death	0.1	0.1	0.3	-0.5	0.2	0.0
Worrier / anxious feelings	2.5	4.8	7.3	-0.5	2.6	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.5	0.6	-0.6
Falls in the last year	1.2	1.6	2.4	-0.7	1.4	-1.5
Hair/balding pattern: Pattern 3	0.7	1.0	2.9	1.7	-0.3	0.3
Number of live births	1.0	1.5	4.2	2.1	-0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.2	-1.5	1.2	-1.1
Pulse rate	3.7	6.2	8.6	1.3	-2.9	2.9
Happiness	0.3	0.4	0.8	-0.9	-0.4	0.4
Noisy workplace	0.1	0.2	0.3	-0.2	0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.1	0.5	1.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.0	0.7	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.8	0.3	-0.3
Asthma	0.8	1.6	2.1	-0.9	1.4	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.8	-0.9	0.8	-0.7
Medication: Cholesterol lowering	1.1	1.8	2.0	1.1	-1.4	1.4
Depression (self-reported)	1.7	2.0	2.9	-0.7	1.7	-1.6
Medication: Lansoprazole	0.9	1.1	1.7	-0.5	1.2	-1.3
Prospective memory result	0.0	0.0	0.0	-0.1	-0.1	0.1
Lung cancer (father)	0.0	0.0	0.0	0.1	0.1	-0.1
Illnesses of mother	1.4	1.7	4.9	-2.2	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.1	-1.1	1.0	-1.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.1	-0.2	-0.1
Impedance of arm (left)	0.5	2.2	6.5	-2.5	0.2	-0.2
Arm fat mass (right)	0.9	3.6	10.8	3.3	-0.0	0.2
Trunk predicted mass	0.3	1.6	2.4	1.6	1.0	-1.1
Standing height	0.3	2.7	3.3	-1.6	1.5	-1.8
Length of working week for main job	5.2	5.8	6.9	2.6	-2.3	2.3
Exposure to tobacco smoke at home	0.7	0.8	1.8	1.4	-0.5	0.6
Breastfed as a baby	0.4	0.5	0.8	-0.9	0.5	-0.7
Tense / ‘highly strung’	0.0	0.0	0.1	0.2	-0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.1	0.3	1.8	-1.7
Hair/balding pattern: Pattern 4	0.5	1.2	1.5	-1.2	-1.0	1.0
Birth weight of first child	2.2	4.0	4.8	1.9	-1.9	2.2
Peak expiratory flow (PEF)	0.2	0.4	0.6	-0.8	0.5	-0.6
Pulse wave reflection index	1.0	1.3	1.8	-0.8	1.2	-1.3
Ever highly irritable/argumentative for 2 days	2.0	2.4	3.2	-1.0	1.8	-1.7
Loud music exposure frequency	0.2	0.2	0.3	-0.2	0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	4.5	0.6	2.1	-1.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-1.0	0.6	-0.3
Blood clot in the leg (DVT)	0.3	0.4	0.9	1.0	-0.4	0.3
Medication: Paracetamol	0.1	0.2	0.2	-0.4	0.4	-0.3
Headache pain in last month	0.6	1.1	1.7	-0.1	1.3	-1.2
Medication for cholesterol, blood pressure or diabetes	3.4	5.6	6.7	-2.6	2.2	-2.3
Glaucoma (self-reported)	0.8	0.9	1.3	-0.6	1.2	-1.0
Gout (self-reported)	0.7	1.0	1.5	0.1	-1.2	1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.0	1.0	-0.8	0.7
Medication: Amlodipine	1.0	1.4	1.7	1.2	-1.1	1.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.1	0.4	-0.5
Birth weight	0.1	0.2	0.3	0.6	0.3	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.8	0.2	-0.2
High blood pressure (siblings)	0.2	0.3	0.4	-0.4	-0.6	0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	0.5	-0.7	0.6	-0.7
Body fat percentage	0.8	3.2	9.1	3.0	-0.4	0.6
Leg fat percentage (right)	1.8	6.6	16.1	4.0	-1.3	1.4
Arm fat-free mass (right)	0.3	1.7	2.8	1.7	1.0	-1.2
Exposure to tobacco smoke outside home	0.4	0.5	0.7	0.8	-0.8	0.6
Comparative body size at age 10	0.4	1.2	1.4	1.2	1.1	-1.0
Number of full brothers	0.2	0.2	0.6	0.8	-0.2	0.2
Worry too long after embarrassment	0.9	1.5	2.0	-0.8	1.4	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.1	0.2	1.0	-1.1
Wheeze or whistling in the chest in last year	0.4	0.7	0.9	0.4	1.0	-0.9
Number of children fathered	1.7	2.0	2.8	0.7	-1.7	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	0.8	-0.5	0.5
Age at first live birth	0.5	0.9	2.3	-1.5	0.6	-0.5
Pulse wave peak to peak time	0.0	0.0	0.0	-0.1	0.2	0.1
Health satisfaction	0.4	0.5	0.9	0.2	-0.7	1.0
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.6	-0.6	0.8
Qualifications: College or University degree	0.1	0.3	0.4	0.4	0.6	-0.6
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.1	-0.5	0.5
Mouth/teeth dental problems: Loose teeth	1.6	1.9	2.2	-1.5	1.3	-1.3
Emphysema/chronic bronchitis	0.2	0.2	0.2	0.4	-0.5	0.4
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.1	-0.3	0.2
Neck or shoulder pain in last month	0.7	1.1	1.5	0.7	1.1	-1.2
Medication: Blood pressure	1.4	2.5	3.4	1.8	-1.5	1.4
Angina (self-reported)	0.1	0.1	0.2	-0.4	0.0	0.3
Migraine (self-reported)	2.2	2.8	4.8	-2.2	1.3	-1.4
Medication: Ibuprofen	1.1	1.3	1.5	-1.0	1.2	-1.1
Medication: Allopurinol	0.0	0.0	0.1	-0.3	-0.1	0.1
Medication: Omeprazole	2.7	3.2	3.7	1.9	-1.8	1.7
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.6	0.0	-0.3
Mean time to correctly identify matches	0.9	1.7	4.3	2.1	-0.7	0.6
Heart disease (mother)	1.1	1.3	2.6	1.6	-0.7	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.6	-1.2	1.1	-1.3
Whole body fat mass	0.8	3.4	10.1	3.2	-0.0	0.2
Leg fat mass (right)	1.0	3.8	11.4	3.4	-0.2	0.3
Arm predicted mass (right)	0.3	1.7	4.0	2.0	0.8	-0.8
Pulse rate, automated reading	0.0	0.1	0.2	0.4	-0.2	0.1
Alcohol intake frequency.	0.6	1.3	3.5	1.9	0.5	-0.4
Comparative height size at age 10	0.2	0.9	1.4	0.6	1.0	-1.2
Number of full sisters	2.2	2.6	3.3	1.3	-1.7	1.8
Suffer from ‘nerves’	0.2	0.3	0.5	0.1	0.7	-0.6
Overall health rating	0.2	0.4	0.6	-0.0	0.8	-0.8
Chest pain or discomfort	1.6	2.3	4.7	2.2	-1.1	1.1
Had major operations	0.8	1.0	1.6	-0.2	-1.1	1.2
Age at last live birth	0.7	1.1	2.4	-1.6	0.6	-0.6
Family relationship satisfaction	3.4	4.2	5.3	1.4	-2.3	2.3
Leg pain on walking	0.5	0.6	1.3	-1.1	-0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	1.1	0.4	-0.4
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.3	0.5	-2.1	2.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	-1.2	-0.6	0.5
Medication: Aspirin	0.1	0.1	0.4	0.6	-0.1	0.1
Supplements: Vitamin C	0.8	0.9	1.3	1.1	0.9	-0.8
Knee pain experienced in last month	0.6	0.9	1.2	0.7	-0.9	1.1
Hypertension (Self-reported)	1.5	4.2	6.4	2.5	-1.8	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.5	-0.3	0.7	-0.7
Illnesses of father: Heart disease	1.1	1.5	2.4	0.2	-1.4	1.6
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-1.1	0.3	-0.4
Smoking status: Previous	0.1	0.2	0.2	0.0	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.4	-0.5	0.5	-0.7
Whole body fat-free mass	0.3	1.7	1.8	1.3	1.2	-1.3
Leg fat-free mass (right)	0.4	2.2	3.0	0.8	1.7	-1.7
Arm fat percentage (left)	1.0	3.9	11.4	3.4	-0.3	0.5
Average weekly red wine intake	1.3	1.9	2.8	0.9	-1.5	1.7
Handedness (chirality/laterality): Left-handed	3.6	4.3	6.5	-0.9	2.4	-2.6
Mood swings	2.4	4.3	6.7	0.4	2.5	-2.6
Loneliness, isolation	1.2	1.7	2.8	0.5	1.4	-1.7
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.6	-0.3	0.1
Ever had bowel cancer screening	2.2	2.6	7.0	-2.6	-0.5	0.7
Diabetes diagnosed by doctor	2.7	4.4	7.6	2.8	-1.7	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.0	1.2	-1.3	1.4
Friendships satisfaction	0.2	0.3	0.3	-0.4	-0.5	0.6
Qualifications: nursing, teaching	1.6	2.5	2.8	1.5	-1.5	1.7
Commuting to job workplace: Walk	7.5	8.1	11.3	-1.7	3.4	-3.2
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.4	0.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	1.9	1.4	-1.3	1.3
Medication for cholesterol	0.4	0.7	1.1	0.2	0.9	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	7.1	-2.7	1.8	-1.6
Back pain experienced in last month	0.0	0.1	0.1	-0.3	0.1	-0.2
Mineral and other dietary supplements	0.4	0.5	0.9	0.1	-1.0	0.7
Breast cancer (self-reported)	0.1	0.1	0.1	0.0	0.3	-0.4
Asthma (self-reported)	0.6	1.2	1.6	-0.7	1.2	-1.3
Osteoporosis (self-reported)	0.3	0.3	0.5	0.6	-0.7	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.5	0.3	-0.1
Medication: Aspirin	0.5	0.6	0.8	0.9	-0.7	0.7
Medication: Gliclazide	0.0	0.0	0.1	-0.3	0.1	0.1
Illnesses of father: None of the above (group 1)	1.7	2.1	2.1	-1.4	1.4	-1.4
Smoking status: Current	0.4	0.6	1.7	1.3	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	2.6	-1.3	1.6	-1.6
Whole body water mass	0.3	1.4	1.9	1.4	1.0	-1.2
Leg predicted mass (right)	0.4	2.1	2.9	0.8	1.7	-1.7
Arm fat mass (left)	1.0	3.9	11.7	3.4	0.2	-0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	0.4	-0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.6	-1.3	0.3	0.0
Miserableness	0.9	1.5	1.9	0.8	1.4	-1.4
Guilty feelings	0.1	0.2	0.3	0.4	0.5	-0.6
Wears glasses or contact lenses	0.8	0.9	1.2	1.1	-0.9	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.2	-0.4	0.5	-0.5
Hearing aid user	0.3	0.4	1.1	-1.1	-0.0	-0.2
Mother’s age at death	2.1	2.6	3.5	-1.0	1.8	-1.9
Financial situation satisfaction	0.2	0.2	0.3	-0.4	0.3	-0.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.9	-1.7	0.5	-0.6
Commuting to job workplace: Public transport	2.3	2.8	3.2	-1.4	1.8	-1.8
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	-0.3	0.8	-0.8
Medication: Blood pressure	0.7	1.3	1.5	1.2	-1.1	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	0.5	-0.7	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.1	1.7	-0.6	1.3	-1.2
High cholesterol (Self-reported)	0.1	0.2	0.2	0.4	-0.5	0.4
Medication: Bendroflumethiazide	0.7	1.1	1.4	0.7	-1.2	1.2
Medication: Paracetamol	0.0	0.1	0.1	0.4	0.2	-0.1
Medication: Lisinopril	0.2	0.3	0.4	0.4	-0.5	0.6
Medication: Atorvastatin	0.4	0.5	0.9	-0.4	0.7	-0.9
Illnesses of father: High blood pressure	0.5	0.6	1.2	1.1	-0.5	0.5
Alcohol drinker status: Never	0.5	0.6	0.8	0.8	0.9	-0.8
Ever smoked	0.7	1.3	1.4	1.1	-1.2	1.1
Basal metabolic rate	0.3	1.8	3.0	1.7	1.1	-1.1
Leg fat percentage (left)	1.7	6.1	15.8	4.0	-1.1	1.2
Arm fat-free mass (left)	0.4	1.9	4.7	2.2	0.7	-0.8
Number of operations (self-reported)	0.7	1.1	1.6	0.1	-1.3	1.2
Average weekly beer plus cider intake	1.3	1.9	2.9	0.4	-1.6	1.7
Irritability	0.7	1.1	1.7	-0.3	1.3	-1.3
Risk taking	1.1	1.6	2.4	0.7	1.4	-1.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	-0.4	-0.9	0.9
Fractured/broken bones in last 5 years	0.8	1.0	3.1	1.8	-0.0	0.1
Age started oral contraceptive pill	3.8	4.8	8.3	-2.9	1.8	-1.7
Diastolic blood pressure, automated reading	0.8	2.6	5.9	2.4	-1.0	0.9
Ever depressed for a whole week	0.5	0.6	1.0	0.3	0.9	-1.0
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.2	0.5	-0.4
Commuting to job workplace: Cycle	0.7	0.8	2.4	-1.5	-0.1	0.1
Myopia	2.4	3.4	4.0	-2.0	1.9	-1.6
Vascular/heart problems diagnosed by doctor	1.1	3.0	4.8	-2.2	1.5	-1.4
Cholesterol lowering medication	0.0	0.0	0.0	-0.2	-0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	3.5	1.3	-1.9	1.7
Pain experienced in last month	1.3	2.2	2.7	1.2	-1.6	1.6
Supplements: Calcium	0.1	0.1	0.1	0.3	-0.4	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.6	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	2.2	2.8	4.0	1.0	-1.8	2.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.5	-0.3	0.2
Heart disease (siblings)	0.1	0.1	0.1	0.3	-0.2	0.4
Alcohol drinker status: Previous	0.4	0.5	0.5	-0.7	-0.7	0.6
Pack years of smoking	2.0	2.9	5.8	2.4	-1.2	1.2
Impedance of whole body	0.5	2.3	7.0	-2.6	0.1	-0.2
Leg fat mass (left)	0.9	3.7	11.0	3.3	-0.1	0.2
Arm predicted mass (left)	0.3	1.6	3.8	1.9	0.6	-0.8