TWAS hub

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0970	0.0270	6.0e-08	0.087	0.084	0.090	0.097	0.090	9.5e-11	1.9e-10	4.9e-11	7.5e-12	4.1e-11
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0355	0.0205	3.6e-03	0.027	0.013	0.006	NA	0.025	4.2e-04	1.2e-02	6.3e-02	NA	6.6e-04
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1130	0.0580	5.6e-03	0.045	0.039	0.044	NA	0.023	1.4e-03	2.6e-03	1.6e-03	NA	1.8e-02
4	TCGA	Lung Squamous Cell Carcinoma	0.0461	0.0244	1.1e-03	0.028	0.017	0.012	NA	0.016	3.4e-04	4.0e-03	1.3e-02	NA	6.0e-03
5	TCGA	Prostate Adenocarcinoma	0.0750	0.0385	1.0e-03	0.002	0.017	-0.001	NA	0.010	1.7e-01	6.1e-03	3.9e-01	NA	2.8e-02
6	TCGA	Soft Tissue Sarcoma	0.1510	0.0640	9.1e-04	0.036	0.081	0.047	NA	0.046	3.2e-03	1.6e-05	9.1e-04	NA	9.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Omeprazole	4.9	5.9	12.4	-0.7	-3.5	-1.2	-3.1	-3.3	-0.8
Lupus	4.2	6.4	9.5	-1.5	-2.9	-2.4	-3.1	-2.7	-2.4
Lung FVC	4.2	21.5	49.3	5.1	5.3	1.3	7.0	4.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.7	23.0	2.7	3.4	0.8	4.8	3.0	0.6
Breast cancer (self-reported)	4.0	4.8	9.5	0.4	-2.4	-2.2	-2.0	-3.1	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.8	4.5	6.7	2.2	2.2	1.6	2.6	2.3	1.6
Angina (self-reported)	3.7	4.8	7.0	1.9	2.6	1.4	2.6	2.6	1.6
Medication: Omeprazole (e.g. Zanprol)	3.6	4.3	8.8	-0.9	-3.0	-1.3	-2.7	-2.5	-1.0
Alzheimer’s Disease (in mother)	3.5	4.1	7.7	0.6	-2.3	-2.8	-1.2	-1.9	-2.5
Angina	3.5	4.6	7.5	1.8	2.5	1.3	2.7	2.5	1.5
Stomach or abdominal pain in last month	3.5	4.4	6.4	-1.4	-2.5	-2.0	-1.8	-2.4	-2.3
Family relationship satisfaction	3.4	4.1	14.3	-3.8	-0.5	2.1	-1.6	-1.1	1.4
Number of incorrect matches in round	3.3	5.5	15.3	-3.9	-2.1	-0.9	-3.1	-1.5	-0.9
Depression (Nagel 2018)	3.2	4.8	9.2	-3.0	-2.5	-0.8	-2.5	-2.4	-0.9
Pulse wave reflection index	3.2	4.0	8.7	0.7	2.3	1.4	2.5	3.0	1.3
Waist Hip Ratio (WHR)	3.1	14.1	26.6	-2.0	-5.2	-1.8	-4.2	-4.7	-3.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.5	21.6	1.7	4.7	1.4	4.1	3.5	1.1
Peak expiratory flow (PEF)	2.9	6.8	14.2	2.1	3.8	1.4	3.3	2.9	0.8
Forced vital capacity (FVC), Best measure	2.8	10.3	26.5	0.3	5.1	2.0	4.2	3.3	1.5
Townsend deprivation index at recruitment	2.6	3.7	6.2	0.6	-2.0	-2.5	-1.1	-2.3	-2.2
Overall health rating	2.6	5.6	9.5	-0.9	-2.7	-2.2	-1.9	-3.1	-2.7
Cardiovascular Disease	2.5	8.4	16.3	0.9	3.6	1.0	3.9	4.0	1.8
Fed-up feelings	2.5	4.5	17.5	-4.2	-1.1	-0.7	-2.4	-1.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	4.8	-2.2	-2.0	-1.6	-1.8	-1.9	-1.4
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	21.0	1.2	4.6	1.2	3.9	3.3	0.9
Age at First Birth	2.4	3.5	7.5	-2.4	-1.9	-0.3	-2.7	-1.9	-0.5
Primary Biliary Cirrhosis	2.4	3.5	6.7	1.0	2.6	2.0	1.7	1.8	1.7
Chronotype (morning person)	2.4	5.5	9.4	3.0	2.6	0.8	3.1	2.4	1.2
Medication: Ventolin 100micrograms inhaler	2.3	2.9	4.4	-0.5	-2.0	-1.6	-1.5	-2.1	-2.0
Sitting height	2.1	15.1	27.2	-4.4	5.2	3.4	1.7	4.0	3.7
Medication: Lansoprazole	2.1	2.3	5.5	0.7	-2.4	-0.7	-1.5	-2.0	-1.1
Health satisfaction	2.1	2.7	4.9	-1.6	-2.2	-0.7	-1.4	-2.2	-1.3
Neuroticism (Nagel 2018)	2.0	4.6	11.1	-3.3	-1.6	-1.7	-1.7	-1.8	-2.2
Worry (Nagel 2018)	2.0	4.2	13.8	-3.7	-1.2	-1.1	-1.7	-1.7	-1.7
Number of children fathered	2.0	2.2	5.7	0.5	1.1	1.3	0.6	2.1	2.4
Neck or shoulder pain in last month	2.0	2.8	6.0	-0.7	-2.5	-0.4	-2.0	-2.4	-0.6
Frequency of depressed mood in last 2 weeks	1.9	2.6	5.9	-1.6	-1.8	-0.7	-1.6	-2.4	-1.0
Impedance of leg (right)	1.9	9.4	21.2	1.6	-4.5	-1.6	-2.1	-4.6	-2.3
Standing height	1.9	18.5	79.9	-8.9	2.5	3.3	-2.1	0.8	3.0
Exposure to tobacco smoke outside home	1.9	2.6	8.8	-3.0	-1.2	-0.6	-1.7	-1.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.2	4.7	0.6	2.2	0.8	1.7	1.9	1.2
Myopia	1.9	2.8	7.8	0.8	2.3	0.9	2.8	1.4	0.4
Alzheimer’s Disease (in father)	1.8	1.9	8.4	-2.9	0.1	1.1	-1.1	-0.1	0.7
Fasting Glucose	1.8	2.1	3.2	-1.7	-1.3	-1.0	-1.5	-1.8	-1.3
Height	1.8	33.8	158.8	-12.6	2.3	3.7	-3.6	0.9	3.4
Impedance of leg (left)	1.8	8.5	21.1	1.1	-4.4	-1.1	-2.1	-4.6	-2.0
Forced vital capacity (FVC)	1.8	6.8	19.3	0.2	4.4	1.2	3.6	2.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.2	0.5	-1.9	-0.4	-0.7	-2.5	-1.4
Osteoporosis (self-reported)	1.8	2.3	6.0	-0.8	-2.4	-0.2	-1.5	-1.9	-0.9
Illnesses of father: None of the above (group 1)	1.8	2.3	5.5	-2.3	-1.1	-0.3	-2.3	-1.3	-0.2
Medication: Paracetamol	1.8	2.8	9.5	1.8	1.7	0.6	3.1	1.0	-0.1
Unable to work because of sickness or disability	1.8	2.3	4.7	0.8	-1.6	-2.2	-1.9	-1.0	-1.1
Waist circumference	1.7	6.1	10.3	-3.0	-2.8	-1.2	-3.2	-2.5	-1.2
Trunk fat-free mass	1.7	9.7	29.6	-5.4	3.7	0.9	-0.5	3.2	2.0
Trunk predicted mass	1.7	9.9	29.8	-5.5	3.7	0.9	-0.5	3.3	2.1
Medication: Paracetamol	1.7	2.8	9.8	1.5	1.9	0.6	3.1	0.9	0.1
Leg fat percentage (right)	1.7	6.3	11.9	-0.3	-3.5	-2.3	-2.3	-3.0	-2.4
Age at first live birth	1.7	3.0	8.3	-1.9	0.9	2.9	0.3	1.4	1.8
Whole body water mass	1.7	9.6	30.7	-5.5	3.5	1.0	-0.5	3.0	2.0
Alcohol drinker status: Never	1.7	2.1	4.7	0.1	-1.9	-0.3	-2.2	-2.0	-0.3
Heel T-Score	1.6	12.7	22.0	1.3	4.6	2.8	4.3	4.7	2.2
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.2	-0.5	1.0	1.7	1.5	0.5	1.8
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.6	-1.8	-1.9	-0.1	-1.2	-1.8	-0.6
Financial difficulties in last 2 years	1.6	2.2	5.8	-0.3	-2.4	-0.2	-2.2	-1.5	-0.1
Pain all over the body in last month	1.6	1.7	4.0	1.4	0.4	-2.0	0.7	0.5	-1.9
Migraine (self-reported)	1.6	2.0	4.5	-0.9	-1.9	0.3	-2.1	-1.5	0.5
Whole body fat-free mass	1.6	9.3	31.1	-5.6	3.3	1.0	-0.6	2.9	2.0
Leg fat-free mass (right)	1.6	8.6	31.0	-5.6	3.0	1.3	-0.6	2.4	1.9
Leg predicted mass (right)	1.6	8.5	30.7	-5.5	3.0	1.3	-0.6	2.4	1.9
Severe depression (siblings)	1.5	1.7	3.6	-0.1	-1.3	-1.9	-1.1	-0.9	-1.8
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	5.0	-0.7	-2.1	0.4	-0.9	-2.2	-0.3
Worrier / anxious feelings	1.5	2.8	5.3	-2.3	-1.6	-1.2	-1.5	-1.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	5.2	-0.6	-2.2	-1.1	-1.1	-2.3	-1.4
Illnesses of mother	1.5	1.9	4.1	-2.0	-1.1	0.1	-1.8	-1.6	-0.5
Body fat percentage	1.5	6.1	11.3	-1.5	-3.4	-1.2	-2.8	-3.3	-1.6
Comparative height size at age 10	1.5	8.5	38.3	-6.2	0.4	1.9	-2.4	-0.6	1.7
Leg fat percentage (left)	1.5	5.2	10.0	-0.7	-3.2	-1.9	-2.3	-2.8	-2.1
Supplements: Calcium	1.5	1.6	3.3	-1.1	-1.4	-0.5	-1.8	-1.6	-0.8
Leg fat-free mass (left)	1.4	7.4	28.9	-5.4	2.7	1.0	-0.7	2.1	1.5
Trunk fat percentage	1.4	5.6	11.2	-1.9	-3.1	-0.7	-2.7	-3.3	-1.2
Current tobacco smoking	1.4	2.4	5.9	0.5	-1.7	-2.4	-1.1	-1.0	-1.8
Leg predicted mass (left)	1.4	7.3	28.8	-5.4	2.6	1.0	-0.8	2.1	1.5
Happiness	1.4	1.8	8.2	-2.9	-0.7	0.8	-0.9	-0.5	0.3
Wheeze or whistling in the chest in last year	1.4	2.4	3.9	0.1	-1.7	-2.0	-1.6	-1.6	-1.7
Shortness of breath walking on level ground	1.4	1.7	4.5	-0.7	-1.8	-0.2	0.1	-2.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.2	1.2	-0.9	-1.3	0.0	-1.6	-1.8
Medication: Atorvastatin	1.4	1.8	4.1	0.7	1.6	1.1	2.0	1.3	0.8
Basal metabolic rate	1.4	7.5	29.5	-5.4	2.7	0.7	-0.9	2.2	1.5
Arm predicted mass (left)	1.4	6.9	24.3	-4.9	2.9	0.2	-0.5	2.6	1.2
Depressed Affect (Nagel 2018)	1.3	2.8	6.7	-2.6	-1.3	-1.2	-1.8	-1.4	-1.2
Alzheimer’s Disease (including proxy)	1.3	1.9	2.9	-0.3	-1.7	-1.4	-1.1	-1.7	-1.5
Coronary Artery Disease (CAD)	1.3	1.6	2.2	0.8	1.4	1.3	1.5	1.3	1.2
Alcohol usually taken with meals	1.3	2.2	5.9	0.5	0.9	2.2	0.1	1.2	2.4
Allergy	1.3	3.0	11.9	-3.4	0.5	0.5	-1.3	1.1	1.6
Falls in the last year	1.3	1.7	4.0	1.2	-0.2	-2.0	0.8	-0.5	-2.0
Pulse wave Arterial Stiffness index	1.3	1.5	2.7	-0.0	1.0	1.6	1.5	1.3	1.1
Exposure to tobacco smoke at home	1.3	1.5	2.7	-1.1	-1.0	-1.5	-1.0	-1.1	-1.6
Arm fat-free mass (right)	1.3	6.9	23.3	-4.8	3.0	0.3	-0.5	2.7	1.3
Arm predicted mass (right)	1.3	6.4	21.1	-4.6	2.9	0.2	-0.5	2.6	1.3
Knee pain experienced in last month	1.3	1.9	8.3	-2.9	-0.4	1.2	-0.6	-0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	4.5	-2.1	1.7	1.6	-0.2	1.5	2.1
Major Depression (MDD)	1.2	1.4	4.0	-2.0	-0.9	1.2	-1.1	-0.9	0.6
Type 2 Diabetes (T2D) (2012)	1.2	1.4	5.1	2.2	0.5	-0.8	1.2	0.4	-0.8
Neuroticism	1.2	3.0	13.6	-3.7	-0.9	-0.3	-1.1	-1.3	-0.9
Supplements: Zinc	1.2	1.3	2.1	0.3	-1.1	-1.4	-0.9	-1.3	-1.4
Impedance of arm (right)	1.2	5.5	15.4	-0.6	-3.4	1.2	-2.1	-3.9	-0.4
Medication: Cholesterol lowering	1.2	1.8	5.3	2.3	0.9	-0.6	1.5	1.4	0.2
Lung cancer (father)	1.2	1.4	4.2	0.6	1.6	0.6	2.0	0.3	0.8
Glaucoma (self-reported)	1.2	1.5	3.9	1.2	0.9	1.2	2.0	0.4	1.0
Pulse wave peak to peak time	1.2	1.4	2.5	-0.6	-0.9	-1.4	-1.6	-1.3	-0.9
Heart disease (mother)	1.2	1.5	3.3	0.3	1.1	1.3	0.7	1.4	1.8
Supplements: Vitamin C	1.2	1.4	3.3	-0.3	-1.3	-1.3	-1.8	-1.2	-0.5
Arm fat-free mass (left)	1.2	6.1	21.8	-4.7	2.7	-0.2	-0.7	2.4	0.9
Impedance of whole body	1.2	5.9	17.8	0.5	-3.7	0.7	-1.7	-4.2	-0.7
Hayfever, allergic rhinitis or eczema	1.1	2.4	11.6	3.4	0.2	0.6	1.7	0.1	-0.0
Had other major operations	1.1	1.3	6.5	2.6	-0.7	0.6	0.4	-0.4	0.5
Neuroticism score	1.1	2.3	10.0	-3.2	-0.9	-0.2	-0.9	-1.3	-0.8
Prospective memory result	1.1	1.4	7.1	-2.7	-0.4	0.2	-0.4	-1.0	-0.4
Impedance of arm (left)	1.1	4.9	13.9	-0.1	-2.9	2.0	-1.6	-3.7	0.3
Tense / ‘highly strung’	1.1	1.8	7.2	-2.7	-0.4	-0.0	-0.4	-1.1	-1.4
Emphysema/chronic bronchitis	1.1	1.2	3.1	1.0	-0.6	-1.8	-0.1	-0.6	-1.6
Smoking status: Current	1.1	1.8	5.5	0.5	-1.4	-2.3	-0.9	-0.6	-1.4
Illnesses of father: High blood pressure	1.1	1.4	3.6	1.1	1.1	0.0	1.9	1.5	0.2
Commuting to job workplace: Cycle	1.1	1.4	5.2	2.3	0.0	-1.3	0.4	0.4	-1.0
Bipolar Disorder (2018)	1.0	1.6	6.1	2.5	1.2	-0.3	0.8	1.2	0.4
Ever had hysterectomy (womb removed)	1.0	1.1	2.4	-0.9	-1.4	-0.5	-1.5	-1.1	-0.0
Diabetes (father)	1.0	1.2	3.3	1.8	1.0	0.2	1.7	0.2	-0.4
Pack years adult smoking proportion	1.0	1.5	4.9	-0.1	-0.6	-1.3	0.3	-1.4	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.5	1.8	1.7	0.4	1.2	2.1	1.3
High blood pressure (mother)	1.0	1.5	5.7	2.4	0.6	-0.9	0.7	1.2	0.1
Trunk fat mass	1.0	4.2	11.0	-3.3	-1.8	-0.2	-2.6	-2.1	-0.4
Had menopause	1.0	1.2	2.5	-1.6	-0.8	-0.5	-1.0	-1.3	-1.1
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.4	1.3	1.2	1.8	1.2	1.1	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.7	0.3	0.8	-1.5	0.9	0.6	-1.9
Mean time to correctly identify matches	1.0	1.8	4.5	-2.1	-1.2	0.8	-1.6	-1.2	0.5
Had major operations	1.0	1.2	1.8	-1.2	-1.3	1.3	-0.7	-1.1	0.8
Leg pain on walking	1.0	1.3	3.3	0.1	-0.7	-0.7	0.3	-1.8	-1.8
Mood swings	1.0	1.8	3.4	-1.3	-1.1	-1.8	-0.9	-1.3	-1.4
Long-standing illness, disability or infirmity	1.0	1.5	2.6	-0.2	-1.2	-1.5	-0.9	-1.6	-1.4
Ever had bowel cancer screening	1.0	1.2	3.3	-1.1	-1.3	0.0	-1.8	-0.8	0.4
Qualifications: nursing, teaching	1.0	1.5	2.6	1.0	1.1	1.6	1.5	1.2	0.8
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	1.2	0.7	1.2	1.5	0.3	1.1
Heart disease (siblings)	1.0	1.2	2.2	-1.0	-1.3	-0.0	-1.3	-1.5	0.5
HDL Cholesterol	0.9	1.5	3.6	-0.4	1.9	1.2	1.1	1.4	0.5
Neuroticism (2016)	0.9	1.3	2.0	-1.2	-1.4	0.7	-1.4	-1.2	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.6	-1.6	-1.2	-0.7	-1.3	-1.3	-0.7
Medication: Ramipril	0.9	1.2	2.4	0.3	1.6	1.0	1.3	1.3	0.7
Time employed in main current job	0.9	1.1	4.4	-0.1	-0.2	-1.2	0.2	-0.7	-2.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	4.2	-2.0	-0.5	0.3	-1.5	-0.2	0.7
Blood clot in the leg (DVT)	0.9	1.1	2.5	0.2	-0.8	-1.2	-0.1	-1.6	-1.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.5	-1.9	-0.1	0.6	-1.3	-0.2	0.9
Whole body fat mass	0.9	3.7	8.7	-3.0	-1.8	-0.6	-2.4	-2.0	-0.7
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.7	-1.6	0.8	0.1	-0.2	1.6	0.7
Irritability	0.9	1.6	7.7	-2.8	-0.3	1.2	-0.2	-0.6	0.2
Vascular/heart problems diagnosed by doctor	0.9	2.3	5.1	-1.3	-1.8	-0.1	-2.3	-1.9	-0.7
Pain experienced in last month	0.9	1.5	3.0	1.0	1.7	0.6	1.2	1.7	0.6
Schizophrenia vs Biploar Disorder	0.8	1.1	2.2	-1.3	-1.0	-0.6	-0.7	-1.5	-1.0
Systolic Blood Pressure	0.8	3.9	14.1	1.2	2.3	0.1	3.8	1.4	-0.7
Respiratory disease	0.8	1.9	3.1	0.7	-1.3	-1.4	-1.0	-1.7	-1.8
Sensitivity / hurt feelings	0.8	1.4	2.3	-0.2	-1.5	-1.5	-1.1	-1.0	-1.2
Hand grip strength (right)	0.8	2.2	4.7	-1.3	2.2	0.9	1.1	1.8	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.8	1.7	-0.4	0.5	1.5	-0.6	-0.8
Weight	0.8	4.0	20.8	-4.6	0.7	0.2	-1.5	0.3	0.5
Arm fat percentage (right)	0.8	3.1	6.4	-0.9	-2.5	-0.8	-2.0	-2.4	-1.1
Hip circumference	0.8	3.4	14.2	-3.8	-0.9	-0.0	-2.1	-0.9	0.3
Noisy workplace	0.8	0.9	3.3	-0.0	-0.9	-0.8	-0.8	-1.8	-0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	3.3	1.8	0.8	-0.4	1.8	0.5	-0.6
Medication: Amlodipine	0.8	1.1	4.9	2.2	0.7	-0.5	0.9	0.5	-0.3
Suffer from ‘nerves’	0.8	1.3	7.1	-2.7	-0.3	-0.2	-0.5	-0.4	-0.5
Age at last live birth	0.8	1.1	2.7	-1.2	0.5	1.6	-0.4	0.9	1.2
Average weekly red wine intake	0.8	1.2	4.5	0.0	-1.2	0.1	-2.1	-0.7	0.7
Mineral and other dietary supplements	0.8	1.1	1.8	-0.5	1.2	1.3	1.1	0.9	1.1
Wears glasses or contact lenses	0.8	1.0	2.0	1.0	-0.1	1.4	1.1	-0.1	1.3
Ever taken oral contraceptive pill	0.8	0.9	2.5	1.6	0.7	0.1	0.8	1.0	1.0
Financial situation satisfaction	0.8	0.9	2.1	-0.8	-1.4	-0.2	-0.9	-1.4	-0.3
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.1	0.1	1.4	0.5	1.8	0.6	0.2
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.8	-1.4	0.8	1.2	-0.1	1.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.3	0.4	-0.6	-1.1	0.1	-1.5	-1.5
Pack years of smoking	0.8	1.2	4.0	0.2	-0.3	-1.0	0.8	-1.3	-2.0
Reaction Time	0.7	1.4	5.7	-2.4	-0.2	1.1	-0.7	-0.6	0.8
Prostate Cancer	0.7	0.9	2.4	1.6	0.6	-0.8	1.3	0.2	-0.6
Bipolar Disorder (2011)	0.7	0.7	1.6	1.1	0.6	1.0	0.3	-0.0	1.2
Crohns Disease (2012)	0.7	1.1	2.7	-0.5	0.8	1.6	0.6	0.5	1.5
HbA1C	0.7	0.8	1.7	-0.7	1.0	0.4	-0.1	1.3	1.1
Hearing difficulty/problems: Yes	0.7	1.1	5.3	2.3	0.4	-0.1	0.7	0.1	-0.5
Medication for hormone replacement therapy	0.7	0.8	1.6	-0.8	0.9	1.3	1.1	-0.2	0.5
Medication: Co-codamol	0.7	0.8	2.8	-1.7	-0.7	-0.7	-0.8	-0.5	-0.5
Diabetes (mother)	0.7	0.9	1.8	0.9	-1.3	-0.8	-1.3	-0.5	-0.2
Hearing difficulty/problems with background noise	0.7	1.1	2.8	0.8	-1.1	-0.6	-0.8	-1.7	-0.9
Alcohol intake versus 10 years previously	0.7	1.0	1.9	-0.4	1.4	0.7	1.3	0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	-1.4	0.6	1.2	0.4	-0.9	0.2
Leg fat mass (right)	0.7	2.8	6.3	-2.5	-1.5	-1.0	-1.9	-1.5	-1.1
Chest pain or discomfort	0.7	1.0	1.8	0.6	-0.9	-1.0	-1.3	-1.3	-0.7
Hypertension (Self-reported)	0.7	1.9	4.0	0.8	1.6	0.2	2.0	1.9	0.8
Illnesses of father: Heart disease	0.7	0.9	3.1	0.9	0.9	0.9	1.8	0.0	0.1
Arm fat percentage (left)	0.7	2.7	5.5	-0.9	-2.4	-0.4	-1.8	-2.3	-0.8
Friendships satisfaction	0.7	0.9	3.1	-1.8	-0.6	0.3	-0.8	-0.9	0.2
Average weekly champagne plus white wine intake	0.7	1.0	2.0	-0.3	1.2	0.8	0.2	1.2	1.4
Guilty feelings	0.7	1.0	1.9	-1.2	-0.9	-0.5	-0.5	-1.1	-1.4
Mother’s age at death	0.7	0.9	1.9	-1.3	-0.9	0.4	-1.4	-0.4	0.8
Diastolic blood pressure, automated reading	0.7	2.1	7.2	1.3	1.1	-0.7	2.7	0.8	-1.2
Ever depressed for a whole week	0.7	0.9	1.8	-1.3	-1.0	0.7	-1.2	-0.1	0.9
Leg fat mass (left)	0.7	2.6	7.8	-2.8	-1.2	-0.8	-1.8	-1.3	-0.8
Breast Cancer	0.6	1.4	1.9	-0.6	-1.4	-1.4	-1.2	-1.2	-1.2
Hypothyroidism (self reported)	0.6	1.5	3.4	-1.2	1.2	1.9	1.1	0.3	1.1
Hand grip strength (left)	0.6	1.6	3.7	-1.0	1.9	0.7	1.0	1.4	1.2
Medication: Levothyroxine sodium	0.6	1.1	3.2	0.3	1.8	-0.0	1.6	0.7	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	0.9	0.1	-1.3	0.5	1.1	-0.3
Nervous feelings	0.6	1.1	2.8	-1.7	-0.9	-0.7	-0.3	-1.0	-1.2
Pulse rate	0.6	1.0	1.9	0.7	-1.4	-0.7	-0.5	-1.4	-1.0
Number of full brothers	0.6	0.7	2.4	-0.4	-0.2	-0.3	-1.6	0.3	1.3
Worry too long after embarrassment	0.6	1.1	3.0	-1.0	-0.3	-1.4	0.4	-0.4	-1.7
Commuting to job workplace: Walk	0.6	0.6	1.5	-0.2	0.8	1.2	0.6	0.3	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	-1.2	1.2	0.6	1.0	0.9	0.5
Medication: Aspirin	0.6	0.7	1.6	1.3	0.7	-0.5	0.8	1.2	-0.1
Hearing aid user	0.6	0.6	1.1	-0.5	0.8	0.9	1.0	1.1	0.2
Medication: Blood pressure	0.6	1.2	3.3	0.8	1.4	-0.0	1.8	1.0	-0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	-1.1	-1.1	-0.1	-0.8	-1.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.8	0.3	-0.6	-1.2	-0.1	-0.7	-1.4
Medication: Lisinopril	0.6	0.7	2.3	1.5	0.8	0.1	0.5	0.9	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.6	1.6	-0.2	-1.0	0.5	0.2	-0.9
Alcohol drinker status: Previous	0.6	0.7	1.4	0.0	-1.1	-0.8	-1.2	-0.8	-0.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	-1.3	0.2	1.1	-0.2	-0.0	0.9
Smoking Status	0.5	1.1	4.2	0.2	-0.7	-2.0	-0.7	0.1	-1.3
Allergy or Eczema	0.5	1.4	5.9	2.4	0.3	0.7	1.3	0.3	0.3
Lung FEV1/FVC ratio	0.5	2.4	5.1	2.2	-1.4	-2.1	-1.3	0.3	-1.1
Vitamin and mineral supplements	0.5	0.7	1.8	0.8	0.5	1.1	1.3	-0.3	0.0
Average weekly fortified wine intake	0.5	0.6	1.4	0.3	0.8	1.0	0.5	0.7	1.2
Taking other prescription medications	0.5	0.7	2.0	-0.1	-0.8	-0.3	0.1	-1.3	-1.4
Serious illness, injury or assault to yourself	0.5	0.6	1.1	1.1	0.5	0.7	1.0	0.1	0.7
High blood pressure	0.5	1.5	3.1	0.8	1.4	0.2	1.8	1.6	0.8
Qualifications: None of the above	0.5	1.0	2.1	-0.4	-0.8	-1.4	-0.2	-1.0	-1.4
Heart attack	0.5	0.7	2.1	1.5	-0.2	-0.9	0.6	0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.7	1.6	0.2	-0.7	0.7	0.1	0.0
Depression (self-reported)	0.5	0.6	1.7	-0.4	1.0	-0.2	0.7	1.3	0.5
Birth weight of first child	0.5	0.9	2.2	-0.8	-0.6	-1.5	-1.2	-0.6	-0.5
Loud music exposure frequency	0.5	0.5	1.0	-1.0	-0.5	0.9	-0.4	-0.8	0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.4	-0.9	0.4	1.2	-0.9	0.5	1.1
Medication: Aspirin	0.5	0.7	1.4	1.2	0.7	-0.4	0.9	1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.2	-0.9	0.5	-0.7	-1.0	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.3	-1.1	-0.9	0.9	-0.4	-0.1	0.3
Back pain experienced in last month	0.5	0.8	3.0	0.1	0.8	0.8	1.7	-0.1	0.3
Commuting to job workplace: Public transport	0.5	0.6	2.7	1.7	-0.1	-0.6	0.4	-0.3	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	-1.4	-0.1	1.0	-0.4	0.2	0.6
Ovarian Cancer	0.4	0.5	1.4	-1.0	-0.6	0.0	-0.4	-1.2	-0.6
Ulcerative Colitis	0.4	0.6	1.5	-0.5	-0.9	-0.2	-1.2	-0.8	-0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	0.2	0.7	0.9	1.2	-0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.3	1.1	-0.0	1.1	0.6	0.1
Medication: Metformin	0.4	0.6	2.0	0.9	0.0	-0.9	0.2	-0.1	-1.4
Maternal smoking around birth	0.4	0.6	1.3	1.0	-0.2	-1.1	0.0	-0.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.1	0.1	-1.1	-1.5	-0.4	-0.5	-0.6
Headache pain in last month	0.4	0.6	1.7	0.4	-1.1	-0.1	-0.5	-1.3	-0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.2	-1.5	-0.2	0.1	-0.6	-1.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	-1.0	1.2	1.1	1.0	-0.2	0.5
Birth weight	0.4	0.9	2.3	-0.7	-1.5	-0.4	-1.4	-0.6	0.1
Qualifications: College or University degree	0.4	1.2	2.7	1.6	0.8	1.1	0.4	1.1	1.1
Medication: Ibuprofen	0.4	0.5	1.4	1.2	-0.1	0.2	1.2	0.3	0.4
Asthma (self-reported)	0.4	0.9	2.0	0.0	-0.8	-0.6	-0.7	-1.4	-1.2
Number of operations (self-reported)	0.4	0.5	2.0	-0.1	-0.4	1.4	-0.0	-0.6	0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.2	1.1	-0.3	-0.9	-0.0	0.2	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.2	1.8	-0.2	0.9	-0.0	0.5	1.1
Schizophrenia (2018)	0.3	0.6	1.6	-0.4	-0.3	-0.6	-0.1	-1.2	-1.3
Crohns Disease (2017)	0.3	0.6	2.2	-0.9	0.4	1.5	0.4	0.2	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.6	1.3	-0.7	1.0	-0.1	-0.2	0.9
LDL Cholesterol	0.3	0.5	1.1	-0.8	-0.7	-0.0	-1.1	0.2	0.7
Rheumatoid Arthritis	0.3	0.5	1.1	1.0	-0.0	-1.0	-0.2	-0.4	-0.8
Relative age of first facial hair	0.3	0.7	2.2	0.7	0.8	-0.3	1.5	0.0	-0.7
Systolic blood pressure, automated reading	0.3	0.9	2.2	0.9	-0.7	-1.0	0.7	-0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.8	1.3	0.9	-0.5	0.4	1.2	0.6
Medication: Simvastatin	0.3	0.4	1.6	1.2	0.4	-0.1	0.3	0.4	0.6
Illnesses of siblings	0.3	0.5	1.0	0.7	1.0	-0.2	0.7	0.7	-0.5
Hair/balding pattern: Pattern 3	0.3	0.5	1.2	-0.5	0.5	0.7	0.4	1.1	0.7
Asthma	0.3	0.6	1.5	0.3	-0.5	-0.4	-0.5	-1.2	-1.2
Arm fat mass (right)	0.3	1.2	4.4	-2.1	-0.7	-0.6	-1.2	-0.8	-0.4
Length of working week for main job	0.3	0.3	1.0	0.0	0.5	0.8	1.0	-0.1	0.1
Medication: Seretide 50 evohaler	0.3	0.3	1.6	-1.3	0.1	-0.2	-0.7	0.0	-0.1
Pulse rate, automated reading	0.3	1.1	2.0	-0.2	-0.9	-1.0	-1.3	-1.4	-1.0
Alcohol intake frequency.	0.3	0.7	1.4	0.1	-0.8	-1.1	-0.6	-1.2	-1.0
Illnesses of siblings: Diabetes	0.3	0.3	0.8	0.2	0.4	0.5	0.3	0.9	0.8
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.8	0.6	0.5	1.0	0.2	0.0
Arm fat mass (left)	0.3	1.4	6.1	-2.5	-0.5	0.1	-1.3	-0.6	0.1
Miserableness	0.3	0.5	1.2	-0.7	-0.4	-1.1	-0.5	-0.6	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.9	-0.1	0.1	-0.9	0.5	-0.2	-1.4
Ever smoked	0.3	0.5	1.0	0.8	-0.4	-1.0	-1.0	0.0	0.1
Average weekly beer plus cider intake	0.3	0.4	0.9	-0.3	0.7	-0.4	1.0	0.8	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	1.2	0.5	-0.7	0.4	-0.2	-0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	-1.2	-0.4	0.9	-0.5	-0.4	0.2
Ulcerative Colitis (UC)	0.2	0.4	1.1	-1.1	-0.6	0.2	-0.7	-0.6	-0.1
Schizophrenia (2014)	0.2	0.4	1.1	-0.8	-0.1	0.7	-0.1	-1.1	0.0
Blood Eosinophil Count	0.2	1.2	5.3	2.3	0.6	-0.8	0.8	0.5	-0.3
Blood Red Count	0.2	2.0	3.5	-0.7	1.8	1.9	1.5	1.3	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	1.0	0.2	-0.9	0.4	-0.0	-0.9
Number of treatments/medications taken	0.2	0.4	0.9	0.1	-0.7	-0.7	0.1	-0.6	-0.9
Average weekly spirits intake	0.2	0.2	0.7	0.8	0.4	-0.3	0.3	-0.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	0.1	-0.7	-0.3	-0.9	-0.2	-0.1
Relative age voice broke	0.2	0.3	0.6	-0.2	-0.8	-0.5	-0.3	-0.8	-0.6
Age when periods started (menarche)	0.2	0.4	1.1	-0.3	1.0	-0.0	0.7	1.1	-0.1
Qualifications: CSEs or equivalent	0.2	0.2	1.0	-0.2	-0.0	-1.0	-0.2	0.4	-0.0
Multivitamins +/- minerals	0.2	0.3	0.7	-0.6	-0.5	-0.5	-0.8	0.1	-0.2
Past tobacco smoking	0.2	0.3	1.2	-1.1	-0.2	0.3	-0.0	-0.5	-0.2
Diabetes (self-reported)	0.2	0.3	1.2	1.1	-0.3	-0.3	-0.1	-0.3	-0.6
Fluid intelligence score	0.2	0.5	0.9	1.0	0.6	0.8	0.5	0.7	0.7
Father’s age at death	0.2	0.3	1.0	0.0	0.4	0.5	0.1	1.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	1.0	-0.6	-0.1	0.5	0.2	0.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	-1.1	-0.3	0.2	0.1	-1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	0.1	0.4	1.0	0.1	0.5	0.9
Gout (self-reported)	0.2	0.2	0.7	-0.3	-0.0	0.7	-0.1	0.4	0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.2	-0.1	0.7	-0.2	0.1	0.7
Medication: Allopurinol	0.2	0.3	1.4	-1.2	0.0	0.1	-0.7	0.3	-0.1
Loneliness, isolation	0.2	0.3	0.6	-0.3	-0.6	-0.8	-0.4	-0.7	-0.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.6	1.2	-0.1	0.1	0.8	-0.3	-0.4
High cholesterol (Self-reported)	0.2	0.3	1.7	0.4	0.2	-0.1	-0.1	1.3	0.4
Risk taking	0.2	0.3	1.1	-1.0	-0.2	-0.0	-0.2	-0.7	-0.3
Age started oral contraceptive pill	0.2	0.2	1.0	-0.2	-0.1	-1.0	-0.3	-0.1	0.3
Mean Putamen Volume	0.1	0.1	0.3	0.3	0.0	-0.1	0.2	-0.1	-0.5
Triglycerides	0.1	0.1	0.4	0.0	0.3	-0.2	0.5	0.6	0.2
Blood White Count	0.1	0.6	1.4	1.2	0.4	-0.7	0.7	1.1	-0.1
Tanning	0.1	1.6	5.9	-2.4	-0.3	0.6	-1.6	0.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.4	0.4	-0.0	0.5	-0.4	-0.2
Supplements: Glucosamine	0.1	0.1	0.2	0.4	0.5	0.1	-0.2	0.4	0.3
Medication: Atenolol	0.1	0.2	0.4	0.1	-0.0	-0.2	0.7	0.5	-0.4
Body mass index (BMI)	0.1	0.4	1.3	-0.5	-0.2	-1.2	-0.3	0.1	-0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.7	-0.1	-0.1	-0.1	-0.4	-0.3
Mouth/teeth dental problems	0.1	0.1	0.3	0.1	-0.4	0.2	-0.5	-0.2	-0.1
Number of live births	0.1	0.2	0.5	0.3	0.4	-0.7	-0.1	0.4	0.1
Breastfed as a baby	0.1	0.1	0.5	-0.7	-0.0	-0.3	-0.2	-0.5	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	-0.4	0.6	-0.1	0.2	0.6	-0.2
High blood pressure (siblings)	0.1	0.2	0.4	0.0	-0.3	-0.3	-0.3	0.5	0.6
Comparative body size at age 10	0.1	0.3	0.5	-0.1	0.4	0.4	0.5	0.7	0.7
Eye problems/disorders: None of the above	0.1	0.2	0.5	-0.1	0.7	-0.4	-0.2	0.1	-0.5
Medication: Blood pressure	0.1	0.2	0.6	0.6	0.1	-0.2	0.1	0.8	0.1
Number of full sisters	0.1	0.1	0.3	-0.2	-0.3	-0.4	-0.5	-0.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.2	0.4	-0.0	-0.2	0.6	0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.5	0.3	-0.1	-0.0	0.5	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.6	-0.2	-0.0	-0.1	-0.4	-0.5
Medication for cholesterol	0.1	0.2	0.8	-0.2	-0.4	-0.3	-0.9	-0.1	0.1
Medication: Gliclazide	0.1	0.1	0.4	-0.6	-0.2	0.0	-0.4	-0.5	-0.1
Cholesterol lowering medication	0.1	0.1	0.5	-0.2	0.2	-0.4	0.2	-0.1	-0.7
Blood Platelet Count	0.0	0.4	0.7	0.4	0.6	-0.8	0.5	0.8	-0.4
BMI	0.0	0.2	0.5	-0.1	0.5	-0.7	0.3	0.7	-0.4
Hair Pigment	0.0	0.6	1.3	-1.1	0.6	-0.8	0.3	-0.2	-1.1
Smoking status: Previous	0.0	0.0	0.1	0.3	0.1	0.2	-0.1	0.3	0.1

Hub : Genes

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