Hub : Genes

LACE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.129	0.0439	3.1e-05	0.102	0.043	0.104	0.107	0.113	4.9e-13	2.5e-06	2.7e-13	1.2e-13	2.5e-14
2	TCGA	Colon Adenocarcinoma	0.155	0.0640	2.4e-04	-0.003	0.046	0.054	NA	-0.003	5.6e-01	1.2e-03	4.3e-04	NA	5.0e-01
3	TCGA	Uterine Corpus Endometrial Carcinoma	0.536	0.1500	4.8e-03	0.037	0.102	0.060	NA	0.048	3.3e-02	8.8e-04	9.3e-03	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.1	0.6	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	-1.6	-0.2	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	0.8	0.8	-0.1	0.9
Depression (Nagel 2018)	0.7	1.0	2.4	1.5	-0.8	-0.1
Intelligence (Savage-Jansen 2018)	3.6	10.9	17.8	-0.8	3.8	4.2
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.2	0.2	0.5
Schizophrenia (2018)	1.2	2.4	4.0	-2.0	-0.6	-1.7
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.1	-0.5	-0.9
Worry (Nagel 2018)	0.2	0.5	1.3	-0.2	-0.4	-1.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.1	0.6	0.1
Alzheimer’s Disease (in father)	1.3	1.4	1.4	1.2	1.2	-1.1
Alzheimer’s Disease (including proxy)	1.0	1.4	3.3	0.8	1.8	0.6
Crohns Disease (2017)	0.6	1.3	2.3	-1.5	-0.8	1.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-0.2	0.4	1.0
Ulcerative Colitis (UC)	0.4	0.8	1.1	0.7	1.0	1.1
Major Depression (MDD)	2.0	2.5	6.9	2.6	0.3	0.6
Reaction Time	3.8	7.2	14.0	0.2	-3.7	-2.7
Verbal and Numeric Reasoning (VNR)	3.8	9.2	17.4	-1.0	3.1	4.2
Breast Cancer	0.1	0.3	0.6	0.6	0.2	-0.8
Ovarian Cancer	0.2	0.3	0.4	0.4	0.5	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.2	0.5	-0.0	0.7	0.3
Bipolar Disorder (2011)	0.1	0.1	0.3	0.2	0.3	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.2	0.6	0.6
Coronary Artery Disease (CAD)	1.3	1.6	2.6	1.3	1.6	-0.6
Crohns Disease (2012)	1.3	2.1	4.5	-2.1	-1.4	-0.2
Mean Putamen Volume	0.2	0.3	0.7	-0.8	0.2	-0.2
Fasting Glucose	0.6	0.7	1.4	1.2	-0.0	0.9
HbA1C	0.3	0.4	0.7	0.9	-0.3	0.6
HDL Cholesterol	0.5	0.9	1.8	-0.8	-1.3	0.6
LDL Cholesterol	0.0	0.0	0.0	0.2	0.0	0.1
Lupus	1.0	1.4	2.4	-1.3	-1.5	0.5
Neuroticism (2016)	2.2	3.2	7.8	2.8	-0.1	-1.4
Primary Biliary Cirrhosis	0.7	1.0	2.6	1.6	-0.3	-0.5
Rheumatoid Arthritis	0.4	0.6	1.0	-0.7	0.4	1.0
Schizophrenia (2014)	0.5	1.1	2.7	-1.6	-0.6	0.3
Triglycerides	1.0	1.7	3.3	1.8	0.6	-1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.5	-0.9	0.4
Ulcerative Colitis	0.4	0.5	1.4	-0.2	1.2	0.4
Blood Eosinophil Count	0.5	3.7	10.5	0.5	-3.2	-0.6
Blood Platelet Count	0.2	2.1	4.4	-0.8	1.1	2.1
Blood Red Count	0.4	3.8	9.9	-0.6	1.1	-3.1
Blood White Count	0.1	1.1	1.5	-1.2	0.5	1.2
Heel T-Score	0.7	5.2	9.7	2.2	0.9	-3.1
BMI	1.3	7.7	10.9	-1.4	3.3	3.2
Height	0.8	15.3	29.1	1.2	3.9	5.4
Waist Hip Ratio (WHR)	0.3	1.3	3.0	0.7	-1.7	0.7
Systolic Blood Pressure	1.4	7.2	16.9	-1.5	-1.6	-4.1
Smoking Status	0.7	1.7	2.4	1.6	-1.1	1.2
Allergy or Eczema	0.9	2.4	2.9	1.3	1.6	1.7
Cardiovascular Disease	0.3	1.1	1.7	-0.8	-0.9	-1.3
Hypothyroidism (self reported)	0.4	0.8	1.9	-0.1	0.7	1.4
Respiratory disease	0.7	1.5	4.3	-0.3	0.2	2.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.6	0.0	-0.5
Lung FEV1/FVC ratio	1.2	6.1	9.7	0.1	3.1	3.0
Lung FVC	0.6	3.0	6.7	-1.3	-2.6	0.8
Neuroticism	0.1	0.3	0.6	0.0	0.6	0.8
Chronotype (morning person)	0.1	0.2	0.3	-0.5	0.1	-0.6
Hair Pigment	0.1	3.3	5.2	-1.0	-1.9	-2.3
Tanning	0.2	2.7	5.2	1.4	-0.9	-2.3
Hand grip strength (left)	0.2	0.5	1.0	0.7	1.0	0.3
Number of treatments/medications taken	0.4	0.7	1.3	-1.1	-0.3	0.9
Average weekly spirits intake	1.5	1.9	4.9	0.3	0.9	2.2
Sensitivity / hurt feelings	0.2	0.3	0.5	-0.3	0.4	0.7
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.9	1.7	0.4	-0.6
Hearing difficulty/problems: Yes	0.8	1.2	3.2	1.8	0.3	-0.4
Relative age of first facial hair	2.0	4.1	7.0	0.5	-2.6	-2.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	-0.1	0.4	1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	0.5	-0.2	1.1
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	1.0	-0.1	-1.3
Systolic blood pressure, automated reading	0.7	2.1	4.2	-0.8	-1.2	-2.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	1.1	0.4	-0.2
Angina	0.2	0.2	0.4	-0.6	-0.6	-0.0
Medication for hormone replacement therapy	0.8	0.9	1.9	1.4	0.8	0.3
Vitamin and mineral supplements	0.5	0.6	0.8	0.8	-0.6	-0.9
Supplements: Zinc	2.1	2.3	3.5	-1.3	1.2	1.9
Medication: Co-codamol	0.5	0.6	1.0	0.8	1.0	0.0
Medication: Metformin	0.0	0.0	0.1	0.3	0.0	0.1
Diabetes (father)	0.1	0.1	0.1	0.2	0.2	0.3
Diabetes (mother)	0.3	0.3	0.5	0.7	-0.6	-0.2
Severe depression (siblings)	1.5	1.7	3.4	-1.3	-0.3	1.8
Pack years adult smoking proportion	0.1	0.2	0.7	-0.0	-0.8	0.1
Impedance of leg (right)	0.9	4.4	7.0	1.3	-2.1	-2.6
Leg fat-free mass (left)	2.8	14.6	22.1	-1.7	4.3	4.7
Trunk fat percentage	0.7	3.0	6.3	-2.5	1.2	1.1
Hand grip strength (right)	0.2	0.5	1.2	-0.3	1.1	0.5
Townsend deprivation index at recruitment	0.6	0.9	1.3	1.0	0.4	-1.2
Current tobacco smoking	1.7	2.8	7.6	0.9	-2.8	0.0
Average weekly fortified wine intake	1.3	1.5	4.1	-0.6	-0.3	2.0
Maternal smoking around birth	0.5	0.8	2.0	1.4	-0.3	0.5
Fed-up feelings	1.5	2.7	7.3	2.7	0.8	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.7	1.6	-0.2	-0.7
Relative age voice broke	0.7	1.1	2.0	0.9	-1.4	-0.6
Taking other prescription medications	1.1	1.7	2.5	-1.3	-1.0	1.6
Age when periods started (menarche)	1.8	4.2	7.7	0.4	-2.2	-2.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	0.3	1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.4	1.3	-0.5	-1.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.3	-0.4	-1.0	2.1
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.7	0.3	-0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.6	-0.0	0.3
High blood pressure	0.9	2.5	3.2	-1.8	-1.8	-1.1
Hayfever, allergic rhinitis or eczema	1.5	3.3	5.3	2.3	2.1	0.5
Multivitamins +/- minerals	0.7	0.9	2.4	-0.2	1.6	0.4
Stomach or abdominal pain in last month	0.7	0.9	1.4	0.7	1.2	0.9
Supplements: Glucosamine	0.4	0.5	1.3	0.5	-0.2	1.1
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	3.3	-1.7	-0.4	1.8
Medication: Atenolol	0.4	0.5	1.4	-0.0	-0.5	-1.2
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.5	-0.1	0.8
Sitting height	1.5	10.6	21.1	-0.5	3.2	4.6
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	0.1	-0.8	-0.8
High blood pressure (mother)	0.8	1.2	2.7	1.6	0.3	-0.9
Body mass index (BMI)	1.1	4.7	5.4	-1.9	2.3	2.3
Impedance of leg (left)	0.9	4.4	7.0	1.3	-2.1	-2.6
Leg predicted mass (left)	2.7	14.3	21.1	-1.7	4.4	4.6
Trunk fat mass	1.4	5.8	5.9	-2.4	2.4	2.4
Waist circumference	1.3	4.7	8.3	-1.6	1.8	2.9
Number of incorrect matches in round	0.2	0.4	1.0	0.1	-1.0	0.2
Past tobacco smoking	0.5	0.9	2.3	-0.1	0.6	-1.5
Alcohol usually taken with meals	0.8	1.3	2.1	-1.1	-0.7	1.5
Nervous feelings	0.9	1.7	3.4	1.2	0.3	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.2	1.4	0.1	-1.8
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.1	-0.2	0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	-0.1	-0.1	-0.8
Had menopause	0.4	0.5	1.0	0.2	-0.7	-1.0
Had other major operations	0.1	0.2	0.3	-0.2	0.6	0.5
Forced vital capacity (FVC)	0.2	0.9	1.0	1.0	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	0.5	-0.6	-1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.2	1.1	0.8	0.4
Qualifications: None of the above	1.7	3.6	6.2	1.0	-1.9	-2.5
Financial difficulties in last 2 years	0.6	0.8	1.9	1.4	-0.5	-0.4
Mouth/teeth dental problems	0.3	0.4	0.8	0.2	0.7	0.9
Heart attack	0.6	0.8	1.2	-1.0	-0.3	1.1
Allergy	1.6	3.6	4.2	-2.0	-2.1	-1.6
Pain all over the body in last month	0.0	0.0	0.1	-0.2	-0.3	0.0
Diabetes (self-reported)	0.2	0.3	0.7	0.4	-0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.2	0.4	0.1	0.0
Medication: Ramipril	0.7	0.9	1.3	0.9	-0.8	-1.1
Medication: Simvastatin	1.9	2.9	4.8	-2.2	-1.8	0.7
Fluid intelligence score	3.8	7.9	13.6	-0.3	3.7	3.2
Illnesses of siblings	0.3	0.4	0.5	0.4	-0.7	-0.7
Neuroticism score	0.2	0.4	0.6	0.8	0.6	-0.4
Weight	2.3	11.4	16.4	-1.8	3.8	4.0
Impedance of arm (right)	1.5	7.2	12.3	0.4	-3.0	-3.5
Arm fat percentage (right)	0.6	2.3	3.8	-1.9	1.2	1.3
Trunk fat-free mass	2.6	15.1	25.3	-0.2	4.5	5.0
Hip circumference	1.7	7.2	9.5	-2.3	3.1	2.6
Time employed in main current job	0.7	0.8	1.6	-1.3	-0.0	0.9
Alcohol intake versus 10 years previously	0.2	0.3	0.4	-0.6	-0.5	0.6
Father’s age at death	0.6	0.8	1.2	-1.1	1.1	0.0
Worrier / anxious feelings	0.3	0.5	0.9	0.9	0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	6.0	2.5	2.0	0.9
Falls in the last year	3.7	5.0	8.1	-1.2	2.3	2.8
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	1.6	0.5	0.9
Number of live births	1.5	2.1	4.4	2.1	0.3	-1.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.2	1.5	1.3	0.5
Pulse rate	0.4	0.7	2.0	-0.4	1.4	0.3
Happiness	1.4	1.7	2.0	1.1	1.4	-1.4
Noisy workplace	0.1	0.1	0.1	-0.4	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	1.1	2.5	5.9	0.2	2.4	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	0.8	1.8	0.5
Mouth/teeth dental problems: Dentures	0.9	1.6	2.4	-1.1	-1.1	1.5
Asthma	0.8	1.5	2.6	0.5	1.3	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.3	0.7	1.5	0.8
Medication: Cholesterol lowering	0.7	1.1	2.6	-1.6	-0.8	0.3
Depression (self-reported)	0.3	0.3	0.9	-1.0	0.1	0.2
Medication: Lansoprazole	1.5	1.7	4.1	-0.6	-2.0	0.8
Prospective memory result	1.9	2.4	4.3	-1.7	-2.1	-0.1
Lung cancer (father)	0.3	0.4	0.6	0.1	0.7	0.8
Illnesses of mother	0.5	0.6	1.7	-1.3	0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.0	0.6	0.9	1.4
Pulse wave Arterial Stiffness index	1.4	1.6	3.5	-1.0	0.5	1.9
Impedance of arm (left)	1.7	7.7	15.6	-0.0	-2.8	-4.0
Arm fat mass (right)	1.4	5.8	7.0	-1.8	2.6	2.6
Trunk predicted mass	2.7	15.2	24.6	-0.2	4.6	5.0
Standing height	1.0	10.0	17.6	-0.0	3.5	4.2
Length of working week for main job	0.2	0.2	0.6	0.7	0.3	-0.3
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.5	0.0	0.5
Breastfed as a baby	0.9	1.1	2.8	1.7	-0.8	-0.0
Tense / ‘highly strung’	0.4	0.6	1.2	-0.8	-0.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.4	-0.4	-2.1	-0.1
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-0.9	-1.5	0.1
Birth weight of first child	0.6	1.1	2.1	1.5	0.3	1.0
Peak expiratory flow (PEF)	1.7	3.9	8.5	2.9	1.8	-0.2
Pulse wave reflection index	0.4	0.5	1.2	0.2	-0.4	1.1
Ever highly irritable/argumentative for 2 days	2.3	2.8	4.8	0.8	2.2	1.7
Loud music exposure frequency	0.1	0.1	0.3	0.3	0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.2	-0.7	2.3	1.7
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	3.3	-1.1	-0.6	-1.8
Blood clot in the leg (DVT)	1.3	1.7	2.4	-0.8	-1.4	1.5
Medication: Paracetamol	0.2	0.3	0.5	0.4	0.7	0.4
Headache pain in last month	0.7	1.1	1.6	0.8	1.3	-1.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.0	1.7	1.7	0.6
Glaucoma (self-reported)	0.4	0.4	0.7	0.7	-0.1	0.8
Gout (self-reported)	0.3	0.4	0.8	0.2	-0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.7	-0.8	0.4	1.6
Medication: Amlodipine	1.1	1.6	3.5	0.7	-0.9	-1.9
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-0.7	-0.8	1.2
Birth weight	0.2	0.5	0.9	0.5	1.0	-0.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.7	-1.3	0.6	1.1
High blood pressure (siblings)	0.0	0.0	0.1	-0.3	-0.1	0.1
Forced vital capacity (FVC), Best measure	0.3	1.1	2.7	0.6	0.5	1.6
Body fat percentage	0.8	3.1	5.1	-2.2	1.6	1.4
Leg fat percentage (right)	0.9	3.1	3.8	-1.9	1.5	1.9
Arm fat-free mass (right)	3.0	15.3	22.8	-1.0	4.8	4.7
Exposure to tobacco smoke outside home	0.2	0.3	0.4	0.7	0.1	-0.6
Comparative body size at age 10	0.1	0.2	0.4	-0.2	0.6	0.2
Number of full brothers	0.4	0.5	0.6	-0.8	-0.8	-0.4
Worry too long after embarrassment	0.3	0.5	0.8	0.9	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	1.1	-0.3	-0.5
Wheeze or whistling in the chest in last year	0.5	1.0	1.7	1.3	-0.3	1.0
Number of children fathered	1.2	1.4	2.5	-1.2	-0.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.4	-0.5	-0.0	1.2
Age at first live birth	0.2	0.3	0.6	-0.4	0.8	0.4
Pulse wave peak to peak time	1.2	1.4	2.3	1.3	-0.2	-1.5
Health satisfaction	0.7	0.9	2.1	-0.2	1.4	0.7
Shortness of breath walking on level ground	0.2	0.2	0.3	0.5	-0.3	-0.5
Qualifications: College or University degree	1.7	5.2	14.4	0.9	3.8	0.7
Eye problems/disorders: None of the above	0.5	0.6	1.6	-0.1	-0.3	-1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.3	-0.5	0.9
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.6	-0.8	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.4	-0.7	-0.5
Neck or shoulder pain in last month	0.6	0.8	1.1	0.7	1.1	0.9
Medication: Blood pressure	0.8	1.4	2.1	-1.4	-1.5	-0.3
Angina (self-reported)	0.4	0.5	0.9	-0.8	-1.0	0.1
Migraine (self-reported)	2.1	2.6	5.8	2.4	-0.3	-1.4
Medication: Ibuprofen	1.0	1.2	2.4	1.0	1.6	0.5
Medication: Allopurinol	0.5	0.7	1.6	0.4	-1.3	-0.6
Medication: Omeprazole	0.6	0.8	0.9	-0.8	-1.0	0.9
Medication: Seretide 50 evohaler	1.3	1.5	2.0	-1.4	1.0	1.2
Mean time to correctly identify matches	3.9	7.5	17.2	-0.0	-4.1	-2.3
Heart disease (mother)	0.5	0.6	0.8	-0.7	-0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-0.6	1.1	0.8
Whole body fat mass	1.6	6.7	8.2	-2.1	2.7	2.9
Leg fat mass (right)	2.0	7.7	10.7	-2.1	2.9	3.3
Arm predicted mass (right)	3.0	15.5	24.4	-1.0	4.9	4.6
Pulse rate, automated reading	0.7	2.3	2.5	-1.5	1.4	1.6
Alcohol intake frequency.	0.1	0.3	0.7	0.9	0.5	0.1
Comparative height size at age 10	0.9	4.7	9.5	0.2	2.1	3.1
Number of full sisters	1.2	1.5	2.4	1.2	-0.7	-1.5
Suffer from ‘nerves’	1.0	1.6	3.6	0.3	-1.0	-1.9
Overall health rating	0.2	0.3	1.0	-0.1	-0.1	1.0
Chest pain or discomfort	0.4	0.5	1.0	1.0	0.4	-0.6
Had major operations	3.3	3.9	7.3	-1.3	-2.7	1.6
Age at last live birth	0.1	0.1	0.3	-0.2	0.6	-0.1
Family relationship satisfaction	1.0	1.2	2.0	1.2	1.4	-0.4
Leg pain on walking	0.1	0.1	0.3	-0.1	0.5	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	6.8	-0.2	-2.6	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.6	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.7	0.7	-0.0
Medication: Aspirin	0.0	0.0	0.1	0.3	0.1	-0.3
Supplements: Vitamin C	0.9	1.0	2.6	-0.2	0.7	1.6
Knee pain experienced in last month	1.6	2.5	3.5	1.9	1.0	-1.7
Hypertension (Self-reported)	1.3	3.6	4.5	-2.1	-2.1	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.3	-0.8	0.3	1.5
Illnesses of father: Heart disease	2.1	2.9	5.3	-0.7	1.6	2.3
Illnesses of siblings: Diabetes	0.4	0.4	1.0	-0.6	-0.1	-1.0
Smoking status: Previous	0.4	0.5	1.5	-0.1	0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.3	0.7	1.1	2.5
Whole body fat-free mass	2.9	16.7	25.7	-0.9	4.8	5.1
Leg fat-free mass (right)	2.7	14.4	21.3	-1.6	4.4	4.6
Arm fat percentage (left)	0.6	2.6	5.2	-2.3	1.2	1.1
Average weekly red wine intake	0.8	1.2	3.1	-0.6	0.3	1.8
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.7	-0.5	1.9	-0.1
Mood swings	0.1	0.2	0.5	0.7	-0.4	0.2
Loneliness, isolation	1.2	1.7	2.7	1.2	1.6	1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.1	0.0	0.8
Ever had bowel cancer screening	1.0	1.1	1.8	-1.1	-0.6	1.3
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.2	-0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.8	1.9	0.4	-0.1
Friendships satisfaction	0.3	0.4	0.7	0.7	0.4	0.8
Qualifications: nursing, teaching	0.4	0.6	1.1	-0.6	0.6	1.1
Commuting to job workplace: Walk	1.1	1.2	3.5	-0.2	-0.2	-1.9
Eye problems/disorders: Cataract	1.2	1.4	3.9	0.1	0.6	2.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.2	0.7	0.5	-1.5
Medication for cholesterol	0.1	0.2	0.3	0.3	0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.9	0.1	-0.1
Back pain experienced in last month	2.9	4.2	9.4	1.2	3.1	1.4
Mineral and other dietary supplements	0.2	0.3	0.7	-0.3	0.8	0.0
Breast cancer (self-reported)	0.1	0.1	0.2	-0.2	-0.4	-0.4
Asthma (self-reported)	0.7	1.4	2.5	0.3	1.3	1.6
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.3	-0.4	0.2
Osteoarthritis (self-reported)	1.3	1.7	4.8	0.7	2.2	0.1
Medication: Aspirin	0.1	0.1	0.3	0.5	0.1	-0.2
Medication: Gliclazide	0.6	0.6	1.0	0.4	0.9	1.0
Illnesses of father: None of the above (group 1)	0.5	0.6	0.6	0.7	-0.7	0.8
Smoking status: Current	1.3	2.0	5.0	1.0	-2.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	1.3	0.9	0.2
Whole body water mass	2.9	16.5	25.0	-0.9	4.9	5.0
Leg predicted mass (right)	2.7	14.5	21.2	-1.6	4.4	4.6
Arm fat mass (left)	1.3	5.3	6.7	-1.9	2.6	2.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	-0.4	-0.1	1.2
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-0.9	-0.4	1.0
Miserableness	0.5	0.9	2.0	1.4	0.7	0.0
Guilty feelings	0.9	1.3	2.3	0.6	1.5	1.1
Wears glasses or contact lenses	0.7	0.8	1.9	-0.4	0.6	1.4
Ever taken oral contraceptive pill	5.6	6.3	16.4	-1.5	-0.4	4.0
Hearing aid user	0.3	0.4	0.9	-0.1	0.4	1.0
Mother’s age at death	1.2	1.5	3.1	-1.8	-1.1	-0.4
Financial situation satisfaction	2.0	2.5	7.0	2.6	-0.3	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	0.6	1.2	-0.2
Commuting to job workplace: Public transport	0.7	0.8	1.3	0.6	-1.1	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	-0.2	0.1	0.8
Medication: Blood pressure	1.1	2.0	3.2	-1.8	-1.3	-1.2
Pain type(s) experienced in last month: Hip pain	1.7	2.2	3.1	0.6	1.8	1.7
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.7	1.3	-0.6	-0.4
High cholesterol (Self-reported)	0.7	1.2	1.3	-1.0	-1.1	1.2
Medication: Bendroflumethiazide	0.6	0.9	1.6	-1.3	1.0	0.2
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.4	-0.1
Medication: Lisinopril	1.4	1.8	3.1	-1.4	-1.8	-0.3
Medication: Atorvastatin	0.3	0.3	0.5	0.7	-0.2	0.6
Illnesses of father: High blood pressure	0.6	0.8	2.2	-0.4	-0.3	-1.5
Alcohol drinker status: Never	0.3	0.3	0.5	-0.6	-0.7	0.1
Ever smoked	0.8	1.5	3.6	0.3	-1.9	0.9
Basal metabolic rate	2.9	16.0	24.4	-1.1	4.8	4.9
Leg fat percentage (left)	0.9	3.1	3.9	-2.0	1.3	1.9
Arm fat-free mass (left)	3.4	17.1	26.3	-0.6	5.0	5.1
Number of operations (self-reported)	1.3	2.0	4.8	-1.1	0.0	2.2
Average weekly beer plus cider intake	1.1	1.6	3.1	1.2	-0.4	-1.8
Irritability	0.0	0.1	0.2	0.1	0.4	-0.0
Risk taking	0.2	0.3	0.7	-0.4	-0.8	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.4	0.4	-1.5	0.2
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.7	0.5	0.2
Age started oral contraceptive pill	1.9	2.3	6.6	-2.6	-0.5	0.2
Diastolic blood pressure, automated reading	0.3	1.1	1.9	-1.4	0.3	-1.1
Ever depressed for a whole week	0.9	1.2	3.0	0.4	1.7	0.5
Unable to work because of sickness or disability	1.1	1.4	3.3	1.8	-0.1	-1.0
Commuting to job workplace: Cycle	1.0	1.2	2.5	1.0	-0.1	-1.6
Myopia	2.1	3.0	7.3	2.7	-1.0	-0.8
Vascular/heart problems diagnosed by doctor	0.9	2.4	3.4	1.9	1.6	1.1
Cholesterol lowering medication	0.4	0.5	1.2	-0.1	-0.6	1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.1	-0.8	-1.0	0.9
Pain experienced in last month	1.8	3.1	8.4	-0.9	-2.9	0.3
Supplements: Calcium	1.7	1.9	5.0	-0.8	0.1	2.2
Basal cell carcinoma (self-reported)	0.8	0.9	1.9	-0.9	1.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.0	-0.9	-0.4	1.0
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	2.8	-0.9	-1.6	1.7
Heart disease (siblings)	1.6	1.9	3.7	-1.0	1.0	1.9
Alcohol drinker status: Previous	0.1	0.1	0.2	0.5	0.2	-0.4
Pack years of smoking	0.2	0.3	0.9	-0.2	-0.9	0.3
Impedance of whole body	1.5	7.5	14.4	0.6	-2.8	-3.8
Leg fat mass (left)	2.0	7.8	11.0	-2.1	2.8	3.3
Arm predicted mass (left)	3.3	17.0	26.8	-0.8	4.8	5.2