TWAS hub - LAPTM5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0606	0.0141	7.6e-10	0.037	0.032	0.035	0.038	0.035	4.2e-12	1.7e-10	2.1e-11	2.7e-12	1.5e-11
2	YFS	Blood	0.0937	0.0184	8.6e-13	0.036	0.058	0.085	0.081	0.085	4.8e-12	2.4e-18	3.1e-26	3.3e-25	1.9e-26

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	11.3	83.8	121.0	6.8	11.0
Primary Biliary Cirrhosis	10.7	15.2	15.3	3.9	3.9
Falls in the last year	6.8	9.2	11.0	3.3	2.7
Number of operations (self-reported)	5.8	8.7	11.8	-2.4	-3.4
Ever had stillbirth, spontaneous miscarriage or termination	5.0	5.4	5.5	-2.3	-2.3
Father’s age at death	4.9	6.6	7.5	-2.4	-2.7
Vitamin and mineral supplements	4.5	6.1	6.2	-2.4	-2.5
Schizophrenia (2018)	4.4	9.2	10.4	3.2	2.8
Fasting Glucose	4.4	5.2	6.5	2.5	2.0
Eye problems/disorders: None of the above	4.0	4.6	5.2	-2.3	-2.0
Angina (self-reported)	4.0	5.3	9.1	3.0	1.2
Leg pain on walking	3.9	4.9	5.6	2.4	2.0
Blood Eosinophil Count	3.8	29.6	32.8	5.7	5.1
Age at first live birth	3.7	6.5	7.6	-2.8	-2.3
Schizophrenia (2014)	3.6	7.9	8.2	2.9	2.8
Ever had hysterectomy (womb removed)	3.6	4.1	5.2	2.3	1.7
Angina	3.6	4.7	7.9	2.8	1.2
Schizophrenia vs Biploar Disorder	3.2	4.2	5.6	2.4	1.7
Hair/balding pattern: Pattern 3	3.2	4.8	5.9	-1.9	-2.4
Breastfed as a baby	3.2	3.9	6.4	1.2	2.5
Number of live births	3.1	4.4	5.2	-2.3	-1.9
Mouth/teeth dental problems: Mouth ulcers	3.1	5.0	6.0	2.4	2.0
Peak expiratory flow (PEF)	2.9	6.8	7.5	-2.7	-2.5
Ever used hormone-replacement therapy (HRT)	2.6	3.3	3.4	-1.8	-1.8
Maternal smoking around birth	2.6	3.8	5.2	2.3	1.5
Multivitamins +/- minerals	2.6	3.3	4.0	2.0	1.6
Medication: Atenolol	2.6	3.3	5.5	2.3	1.0
Comparative body size at age 10	2.6	7.1	10.8	-3.3	-1.9
Pulse wave peak to peak time	2.6	3.1	4.3	-1.4	-2.1
Age at last live birth	2.6	3.8	4.7	-2.2	-1.7
Breast Cancer	2.5	6.1	7.0	2.6	2.3
Pulse rate	2.5	4.3	5.9	1.6	2.4
Unable to work because of sickness or disability	2.5	3.2	5.7	2.4	0.9
Noisy workplace	2.4	2.9	4.1	1.3	2.0
Exposure to tobacco smoke at home	2.4	2.7	4.1	-1.1	-2.0
Had other major operations	2.3	2.8	3.9	-1.3	-2.0
Shortness of breath walking on level ground	2.3	2.8	4.1	2.0	1.2
Smoking status: Current	2.3	3.6	4.9	1.6	2.2
Age at First Birth	2.2	3.2	5.3	-2.3	-1.1
Hypothyroidism (self reported)	2.2	5.0	5.8	-2.1	-2.4
Mother’s age at death	2.2	2.7	2.8	-1.7	-1.6
Average weekly fortified wine intake	2.1	2.5	3.7	-1.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	5.0	-2.2	-2.2
Length of working week for main job	2.1	2.3	2.8	1.7	1.4
Alcohol drinker status: Previous	2.1	2.4	2.5	-1.5	-1.6
Bipolar Disorder or Schizophrenia	2.0	5.0	5.5	2.4	2.1
LDL Cholesterol	2.0	3.2	5.6	-2.4	-0.9
Medication: Amlodipine	2.0	2.8	2.8	1.7	1.7
Alcohol drinker status: Never	2.0	2.4	3.2	1.2	1.8
Pack years of smoking	2.0	2.9	3.4	1.6	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.2	4.9	-2.2	-1.9
Migraine (self-reported)	1.9	2.3	3.8	2.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.2	3.0	1.7	1.2
Smoking Status	1.8	4.3	5.4	2.3	1.8
Medication for hormone replacement therapy	1.8	2.1	2.3	-1.5	-1.4
Health satisfaction	1.8	2.4	3.4	1.8	1.1
Alcohol intake frequency.	1.8	4.1	4.8	1.9	2.2
Illnesses of father: High blood pressure	1.8	2.2	2.6	-1.3	-1.6
Type 2 Diabetes (T2D) (2012)	1.7	1.9	3.7	0.5	1.9
Diabetes (self-reported)	1.7	2.7	3.9	2.0	1.2
Fluid intelligence score	1.7	3.5	3.7	-1.8	-1.9
Alcohol intake versus 10 years previously	1.7	2.6	4.1	1.0	2.0
Pulse wave Arterial Stiffness index	1.7	1.9	3.0	0.9	1.7
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	4.5	-1.4	-2.1
Pulse rate, automated reading	1.7	5.4	8.6	1.5	2.9
Supplements: Vitamin C	1.7	2.1	3.0	1.1	1.7
Medication: Gliclazide	1.7	1.9	3.2	1.8	0.8
Eye problems/disorders: Cataract	1.6	1.9	2.4	1.5	1.2
Medication for cholesterol	1.6	2.4	3.2	1.3	1.8
Prostate Cancer	1.5	2.1	3.0	-1.7	-1.1
Ulcerative Colitis	1.5	2.1	3.4	1.8	0.9
Birth weight	1.5	3.2	5.1	-2.2	-1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.9	-1.7	-0.8
Medication: Blood pressure	1.5	2.8	3.1	-1.6	-1.8
Pain type(s) experienced in last month: Hip pain	1.5	1.8	2.5	1.6	1.1
Medication: Paracetamol	1.5	2.4	4.2	-0.7	-2.1
Age started oral contraceptive pill	1.5	1.8	2.2	1.5	1.2
Mean Putamen Volume	1.4	1.6	2.0	1.1	1.4
Current tobacco smoking	1.4	2.2	3.1	1.2	1.8
High blood pressure (mother)	1.4	1.9	3.0	-1.0	-1.7
Number of children fathered	1.4	1.6	2.2	1.5	1.0
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.7	1.6	0.7
Medication: Atorvastatin	1.4	1.8	2.2	1.5	1.1
Alzheimer’s Disease (in mother)	1.3	1.6	2.7	-1.6	-0.7
Lupus	1.3	2.0	2.0	1.4	1.4
Illnesses of father: Heart disease	1.3	1.8	2.2	1.2	1.5
Ever taken oral contraceptive pill	1.3	1.4	1.8	1.0	1.3
Ever depressed for a whole week	1.3	1.6	2.2	-1.5	-1.1
Ulcerative Colitis (UC)	1.2	2.3	2.6	1.6	1.4
Severe depression (siblings)	1.2	1.4	1.9	0.9	1.4
Pack years adult smoking proportion	1.2	1.8	2.0	1.3	1.4
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	1.3	-1.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.0	-0.9	-1.4
Friendships satisfaction	1.2	1.4	2.0	-1.4	-1.0
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.3	0.9	1.5
Supplements: Calcium	1.2	1.3	2.4	-1.6	0.4
Townsend deprivation index at recruitment	1.1	1.5	2.9	1.7	0.5
Financial difficulties in last 2 years	1.1	1.4	2.3	1.5	0.7
Medication: Cholesterol lowering	1.1	1.7	1.8	1.3	1.3
Medication: Seretide 50 evohaler	1.1	1.3	2.1	1.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.3	-1.5	-1.5
Blood Red Count	1.0	10.0	13.3	2.6	3.6
Heel T-Score	1.0	7.9	12.7	-3.6	-1.8
Medication: Metformin	1.0	1.4	2.4	1.5	0.7
Qualifications: CSEs or equivalent	1.0	1.3	2.0	-0.8	-1.4
Heart attack	1.0	1.3	2.4	1.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.2	-1.5	-0.3
Illnesses of mother	1.0	1.3	1.7	0.9	1.3
Exposure to tobacco smoke outside home	1.0	1.3	2.1	1.5	0.7
Eye problems/disorders: Glaucoma	1.0	1.2	1.9	0.7	1.4
Bipolar Disorder (2011)	0.9	0.9	1.6	-0.5	-1.3
HbA1C	0.9	1.0	1.1	1.0	1.0
Blood Platelet Count	0.9	10.8	12.1	3.5	3.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	2.5	1.6	0.9
Medication: Paracetamol	0.9	1.5	2.9	-0.1	-1.7
Glaucoma (self-reported)	0.9	1.1	1.6	0.7	1.3
Worry too long after embarrassment	0.9	1.5	2.6	-1.6	-0.7
Diabetes diagnosed by doctor	0.9	1.5	2.7	1.6	0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.5	-1.2	-0.9
Lung FVC	0.8	4.3	7.3	1.1	2.7
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	1.3	0.3
Number of incorrect matches in round	0.8	1.4	2.7	1.7	0.2
Depression (self-reported)	0.8	1.0	1.9	-0.3	-1.4
Commuting to job workplace: Public transport	0.8	1.0	1.1	-1.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.1	1.4	0.1
Height	0.7	13.4	14.9	-3.9	-3.5
Lung FEV1/FVC ratio	0.7	3.4	4.5	-1.5	-2.1
Qualifications: None of the above	0.7	1.5	1.9	1.4	1.0
Medication: Lansoprazole	0.7	0.8	1.2	0.6	-1.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	0.3	1.2
Loud music exposure frequency	0.7	0.8	1.2	1.1	0.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	0.9	1.0	0.8
Ever had bowel cancer screening	0.7	0.8	1.6	1.2	-0.3
Osteoporosis (self-reported)	0.7	0.9	1.7	0.4	1.3
Medication: Bendroflumethiazide	0.7	1.1	1.7	-0.7	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.7	1.8	-1.3	-1.3
Neuroticism (2016)	0.6	0.8	1.2	-0.7	-1.1
Hand grip strength (left)	0.6	1.5	2.9	-1.7	0.3
Systolic blood pressure, automated reading	0.6	1.6	2.4	1.6	0.9
Fed-up feelings	0.6	1.2	2.0	1.4	0.5
Medication: Levothyroxine sodium	0.6	1.0	1.3	-0.8	-1.1
Mouth/teeth dental problems: Dentures	0.6	1.0	1.5	-0.6	-1.2
Lung cancer (father)	0.6	0.7	1.2	-0.5	-1.1
Blood clot in the leg (DVT)	0.6	0.8	0.8	-0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	0.3	1.1
Overall health rating	0.6	1.2	2.1	1.5	0.6
Pain experienced in last month	0.6	0.9	1.1	0.9	1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.1	-0.5	1.1
Body Mass Index (BMI) (2010)	0.5	0.6	0.9	0.6	1.0
Respiratory disease	0.5	1.2	1.4	1.2	1.0
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.1	1.1	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	0.9	0.5	0.9
Medication: Co-codamol	0.5	0.6	0.7	0.9	0.6
Hand grip strength (right)	0.5	1.3	2.6	-1.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.2	-1.1	-0.3
Hair/balding pattern: Pattern 4	0.5	1.2	1.2	-1.1	-1.1
Pulse wave reflection index	0.5	0.7	1.1	0.5	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.0	1.0	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.0	-1.0	-0.9
Gout (self-reported)	0.5	0.7	1.1	0.4	1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-0.4	1.2
Medication: Ibuprofen	0.5	0.6	1.2	0.0	-1.1
Chest pain or discomfort	0.5	0.7	1.1	1.1	0.5
Asthma (self-reported)	0.5	0.9	1.2	0.8	1.1
Myopia	0.5	0.8	1.4	0.4	1.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.1	-1.0	-0.9
Number of treatments/medications taken	0.4	0.7	0.8	0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	-0.7	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	0.8	-0.9	-0.3
Happiness	0.4	0.5	0.5	-0.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.9	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.3	-1.5	-0.5
Birth weight of first child	0.4	0.6	0.9	-0.9	-0.6
Headache pain in last month	0.4	0.7	1.1	0.5	-1.1
Emphysema/chronic bronchitis	0.4	0.4	0.7	0.4	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.7	0.6	0.8
Irritability	0.4	0.7	1.0	1.0	0.6
Diastolic blood pressure, automated reading	0.4	1.4	2.7	1.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.1	-1.0
Reaction Time	0.3	0.6	1.0	1.0	-0.5
Average weekly spirits intake	0.3	0.3	0.4	-0.5	-0.6
Taking other prescription medications	0.3	0.5	0.9	0.4	-1.0
High blood pressure	0.3	0.9	1.8	-0.3	-1.4
Worrier / anxious feelings	0.3	0.6	0.7	0.7	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	0.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	-0.7	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.1	2.2	-1.5	-0.2
Number of full brothers	0.3	0.4	0.6	-0.8	-0.3
Medication: Allopurinol	0.3	0.3	0.4	0.6	0.6
Medication: Omeprazole	0.3	0.4	0.7	0.1	-0.9
Mean time to correctly identify matches	0.3	0.6	1.2	1.1	-0.2
Suffer from ‘nerves’	0.3	0.4	0.8	0.9	0.2
Family relationship satisfaction	0.3	0.3	0.6	-0.7	-0.3
Hypertension (Self-reported)	0.3	0.7	1.4	-0.1	-1.2
Illnesses of siblings: Diabetes	0.3	0.3	0.7	0.8	0.0
Osteoarthritis (self-reported)	0.3	0.4	0.4	-0.6	-0.7
Miserableness	0.3	0.5	0.5	-0.7	0.6
Financial situation satisfaction	0.3	0.3	0.5	0.7	0.4
Risk taking	0.3	0.5	0.8	-0.5	-0.9
Neuroticism (Nagel 2018)	0.2	0.6	0.7	-0.7	-0.8
Irritable Bowel Disease (IBD)	0.2	0.6	0.7	0.8	0.7
Ovarian Cancer	0.2	0.2	0.4	0.6	0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.5	-0.1	-0.7
Waist Hip Ratio (WHR)	0.2	0.7	1.4	0.3	-1.2
Systolic Blood Pressure	0.2	1.2	1.8	0.7	1.4
Chronotype (morning person)	0.2	0.6	0.9	0.4	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.5	0.3
Diabetes (father)	0.2	0.2	0.4	0.6	-0.2
Relative age voice broke	0.2	0.3	0.6	0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.2	0.4	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	-0.3	0.9
Impedance of leg (left)	0.2	0.9	0.9	-1.0	-1.0
Waist circumference	0.2	0.7	1.5	1.2	-0.1
Past tobacco smoking	0.2	0.3	0.4	-0.6	-0.5
Alcohol usually taken with meals	0.2	0.2	0.3	-0.4	0.6
Medication: Simvastatin	0.2	0.3	0.5	0.4	0.7
Hip circumference	0.2	1.1	1.9	1.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.1	-1.0	-0.1
Asthma	0.2	0.4	0.6	0.5	0.7
Standing height	0.2	2.4	3.5	-1.9	-1.2
Tense / ‘highly strung’	0.2	0.4	0.7	0.8	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	0.5	0.7
Leg fat percentage (right)	0.2	0.7	1.3	1.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.4	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.9	-0.0
Heart disease (mother)	0.2	0.3	0.5	0.2	-0.7
Comparative height size at age 10	0.2	0.9	1.0	-1.0	-0.9
Had major operations	0.2	0.2	0.5	0.7	-0.0
Mood swings	0.2	0.4	0.7	0.2	0.8
Mineral and other dietary supplements	0.2	0.3	0.6	-0.2	-0.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	-0.2	-0.7
Wears glasses or contact lenses	0.2	0.3	0.6	0.8	0.0
Hearing aid user	0.2	0.3	0.3	0.4	0.6
Medication: Lisinopril	0.2	0.2	0.3	0.6	-0.3
Average weekly beer plus cider intake	0.2	0.3	0.4	0.6	0.4
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.5	-0.6
Heart disease (siblings)	0.2	0.2	0.3	0.2	-0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	-0.6	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.2	0.5
Crohns Disease (2012)	0.1	0.2	0.3	0.5	-0.3
Triglycerides	0.1	0.1	0.2	0.4	-0.2
BMI	0.1	0.5	0.5	0.7	0.7
Allergy or Eczema	0.1	0.3	0.6	-0.1	0.8
Neuroticism	0.1	0.2	0.2	0.5	0.5
Supplements: Zinc	0.1	0.1	0.1	0.4	-0.2
Diabetes (mother)	0.1	0.2	0.3	0.5	-0.2
Impedance of leg (right)	0.1	0.2	0.3	-0.4	-0.6
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.1	0.4
Supplements: Glucosamine	0.1	0.1	0.2	-0.5	0.1
Body mass index (BMI)	0.1	0.2	0.4	0.7	0.0
Nervous feelings	0.1	0.2	0.4	0.6	-0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	0.2
Forced vital capacity (FVC)	0.1	0.4	0.7	-0.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	-0.3	0.5
Allergy	0.1	0.2	0.5	0.0	-0.7
Pain all over the body in last month	0.1	0.1	0.1	-0.2	-0.4
Illnesses of siblings	0.1	0.1	0.2	-0.2	0.4
Neuroticism score	0.1	0.3	0.3	0.5	0.5
Impedance of arm (right)	0.1	0.6	0.8	-0.7	-0.9
Arm fat percentage (right)	0.1	0.2	0.4	0.3	-0.6
Trunk fat-free mass	0.1	0.6	0.6	-0.7	-0.8
Time employed in main current job	0.1	0.1	0.2	-0.5	0.3
Impedance of arm (left)	0.1	0.4	0.4	-0.6	-0.6
Arm fat mass (right)	0.1	0.3	0.5	0.0	-0.7
Trunk predicted mass	0.1	0.5	0.6	-0.7	-0.8
Body fat percentage	0.1	0.3	0.4	0.6	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.4	0.3
Qualifications: College or University degree	0.1	0.2	0.4	-0.7	-0.2
Neck or shoulder pain in last month	0.1	0.2	0.3	0.6	-0.2
Medication: Blood pressure	0.1	0.1	0.2	0.5	0.2
Whole body fat mass	0.1	0.2	0.4	0.2	-0.7
Number of full sisters	0.1	0.2	0.2	0.5	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	0.3	0.5
Knee pain experienced in last month	0.1	0.2	0.2	0.4	-0.4
Smoking status: Previous	0.1	0.2	0.3	0.3	-0.6
Whole body fat-free mass	0.1	0.4	0.4	-0.6	-0.6
Leg fat-free mass (right)	0.1	0.4	0.5	-0.7	-0.5
Average weekly red wine intake	0.1	0.2	0.4	0.0	-0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.3	0.6	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	-0.0
Back pain experienced in last month	0.1	0.1	0.2	0.4	0.3
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.3	0.5
Whole body water mass	0.1	0.4	0.4	-0.6	-0.6
Leg predicted mass (right)	0.1	0.4	0.5	-0.7	-0.5
Arm fat mass (left)	0.1	0.3	0.6	-0.1	-0.8
High cholesterol (Self-reported)	0.1	0.1	0.2	0.2	0.5
Ever smoked	0.1	0.1	0.2	0.0	0.4
Basal metabolic rate	0.1	0.4	0.5	-0.6	-0.7
Leg fat percentage (left)	0.1	0.3	0.6	0.8	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.2	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	-0.3	0.6
Impedance of whole body	0.1	0.4	0.5	-0.7	-0.6
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.2	-0.1
Depression (Nagel 2018)	0.0	0.0	0.1	0.3	0.1
Worry (Nagel 2018)	0.0	0.1	0.2	0.4	0.1
Crohns Disease (2017)	0.0	0.1	0.1	-0.3	-0.2
Major Depression (MDD)	0.0	0.0	0.1	0.0	-0.3
HDL Cholesterol	0.0	0.1	0.1	0.2	0.4
Rheumatoid Arthritis	0.0	0.0	0.1	0.1	0.3
Cardiovascular Disease	0.0	0.0	0.1	0.0	0.3
Hair Pigment	0.0	0.4	0.8	-0.1	0.9
Tanning	0.0	0.6	1.1	0.3	-1.1
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	-0.2
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.0	0.1
Relative age of first facial hair	0.0	0.0	0.1	-0.3	-0.0
Leg fat-free mass (left)	0.0	0.2	0.2	-0.5	-0.3
Trunk fat percentage	0.0	0.2	0.2	0.4	-0.5
Age when periods started (menarche)	0.0	0.1	0.2	-0.2	0.4
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.1	-0.2
Sitting height	0.0	0.2	0.4	-0.6	-0.2
Leg predicted mass (left)	0.0	0.2	0.2	-0.5	-0.4
Trunk fat mass	0.0	0.2	0.4	0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.1	0.3
Had menopause	0.0	0.0	0.0	0.0	0.2
Mouth/teeth dental problems	0.0	0.0	0.1	0.1	-0.3
Medication: Ramipril	0.0	0.1	0.1	0.2	0.2
Weight	0.0	0.1	0.1	-0.1	-0.3
Prospective memory result	0.0	0.0	0.0	-0.1	0.1
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.0	-0.1
High blood pressure (siblings)	0.0	0.0	0.1	0.3	-0.0
Arm fat-free mass (right)	0.0	0.0	0.0	-0.2	-0.2
Leg fat mass (right)	0.0	0.1	0.1	0.3	-0.4
Arm predicted mass (right)	0.0	0.1	0.1	-0.3	-0.2
Medication: Aspirin	0.0	0.1	0.1	0.3	-0.1
Arm fat percentage (left)	0.0	0.2	0.2	0.3	-0.5
Loneliness, isolation	0.0	0.0	0.1	-0.1	-0.3
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.0	0.0
Breast cancer (self-reported)	0.0	0.0	0.1	-0.0	0.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	0.0	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.1	-0.1
Guilty feelings	0.0	0.1	0.1	-0.2	-0.3
Arm fat-free mass (left)	0.0	0.1	0.2	-0.0	-0.5
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.1	0.3
Cholesterol lowering medication	0.0	0.1	0.1	0.1	0.4
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	0.1	-0.3
Leg fat mass (left)	0.0	0.2	0.3	-0.0	-0.6
Arm predicted mass (left)	0.0	0.3	0.4	-0.3	-0.7

Hub : Genes

LAPTM5

Models

Trait associations