Hub : Genes

LBH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0960 0.0360 0.00160 0.028 0.037 0.040 0.043 0.031 1.9e-04 2.5e-05 1.1e-05 4.6e-06 1.0e-04
2 GTEx Skin Sun Exposed Lower leg 0.1130 0.0410 0.00220 0.005 NA 0.009 NA 0.004 1.2e-01 NA 5.8e-02 NA 1.5e-01
3 NTR Blood 0.0261 0.0089 0.00021 0.016 0.013 0.018 0.013 0.010 5.9e-06 3.2e-05 1.5e-06 3.2e-05 2.2e-04
4 YFS Blood 0.2170 0.0309 0.00000 0.089 0.125 0.136 0.129 0.110 1.3e-27 1.5e-38 3.1e-42 5.6e-40 6.2e-34

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.9 0.9 0.0 0.3 -0.5
Bipolar Disorder or Schizophrenia 0.5 1.3 3.9 -0.1 2.0 0.8 0.9
Depressed Affect (Nagel 2018) 2.0 4.2 6.6 -2.6 -1.9 1.9 1.8
Depression (Nagel 2018) 1.0 1.6 2.9 -1.7 0.3 1.7 0.6
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.8 -0.8 -0.0 -0.8 -0.9
Neuroticism (Nagel 2018) 0.9 2.0 3.0 -1.7 -1.6 1.3 1.0
Schizophrenia (2018) 1.2 2.5 6.3 -0.8 2.5 0.8 1.5
Schizophrenia vs Biploar Disorder 0.6 0.8 2.3 -1.5 0.6 0.3 0.7
Worry (Nagel 2018) 0.3 0.6 1.6 -0.8 -1.2 0.4 -0.2
Alzheimer’s Disease (in mother) 0.3 0.4 0.5 -0.5 0.5 0.7 0.6
Alzheimer’s Disease (in father) 0.8 0.9 1.9 -1.1 -1.4 -0.6 -0.0
Alzheimer’s Disease (including proxy) 0.8 1.2 2.8 -1.7 -0.8 0.7 1.0
Crohns Disease (2017) 2.7 5.9 7.9 -2.8 -0.5 2.8 2.8
Irritable Bowel Disease (IBD) 1.9 4.4 7.1 -2.7 1.0 2.0 2.4
Ulcerative Colitis (UC) 1.3 2.4 4.6 -1.6 2.1 0.5 1.5
Major Depression (MDD) 0.7 0.9 1.4 -0.9 1.2 0.5 1.1
Reaction Time 0.1 0.2 0.6 0.2 -0.4 0.8 -0.2
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.5 -1.2 -0.7 -0.1 -0.9
Breast Cancer 0.6 1.4 3.8 0.3 1.9 -1.0 -0.9
Ovarian Cancer 0.7 0.9 1.6 -1.3 -0.6 1.1 0.5
Prostate Cancer 0.1 0.2 0.3 -0.6 -0.2 -0.5 -0.4
Age at First Birth 1.1 1.6 3.2 -1.7 1.8 -0.5 0.4
Bipolar Disorder (2011) 0.8 0.7 1.9 -1.4 -0.3 0.9 0.3
Body Mass Index (BMI) (2010) 0.6 0.8 2.2 0.3 0.4 1.5 0.9
Coronary Artery Disease (CAD) 0.6 0.7 1.2 -0.9 -1.1 0.8 0.5
Crohns Disease (2012) 1.2 1.9 3.6 -1.9 -1.1 1.5 0.6
Mean Putamen Volume 0.2 0.3 0.4 0.2 0.6 0.5 -0.7
Fasting Glucose 0.8 0.9 1.4 0.7 -1.0 0.9 1.2
HbA1C 0.5 0.6 1.5 -1.2 -0.8 0.2 0.1
HDL Cholesterol 1.3 2.1 4.5 1.2 -0.1 -2.1 -1.6
LDL Cholesterol 0.3 0.4 0.6 -0.3 0.8 0.8 0.6
Lupus 1.0 1.4 3.1 0.6 1.8 -0.2 1.5
Neuroticism (2016) 0.8 1.1 2.8 -1.7 -0.8 0.1 1.0
Primary Biliary Cirrhosis 2.6 3.7 10.7 -0.6 -1.2 3.3 1.5
Rheumatoid Arthritis 0.2 0.3 0.9 -0.2 0.3 0.3 0.9
Schizophrenia (2014) 1.1 2.5 5.7 -1.3 2.4 1.1 1.2
Triglycerides 0.6 1.0 2.1 0.2 0.1 1.3 1.4
Type 2 Diabetes (T2D) (2012) 2.6 3.0 6.6 -0.9 -1.0 2.6 1.9
Ulcerative Colitis 0.7 1.0 2.6 -1.6 0.8 0.7 0.6
Blood Eosinophil Count 0.0 0.3 1.0 0.5 -0.0 1.0 -0.4
Blood Platelet Count 0.2 2.7 5.2 -0.3 0.7 2.2 2.3
Blood Red Count 0.2 1.9 3.7 1.9 1.9 0.4 0.4
Blood White Count 0.6 4.8 13.8 3.7 2.1 0.1 1.0
Heel T-Score 0.2 1.5 3.7 -1.9 0.3 -1.1 1.0
BMI 1.0 5.8 9.5 -2.1 -1.0 3.1 2.9
Height 0.8 15.8 36.0 -4.5 -6.0 2.5 0.9
Waist Hip Ratio (WHR) 0.3 1.2 3.3 -0.5 0.5 0.9 1.8
Systolic Blood Pressure 0.2 0.9 2.2 0.2 -1.5 -0.1 -1.1
Smoking Status 0.4 0.9 2.6 1.6 0.4 0.1 0.9
Allergy or Eczema 1.9 4.9 13.9 -0.9 -0.4 3.7 2.2
Cardiovascular Disease 0.5 1.7 3.5 -0.2 -1.9 1.7 0.6
Hypothyroidism (self reported) 0.2 0.4 0.7 -0.6 -0.8 0.6 -0.1
Respiratory disease 1.1 2.4 4.1 -1.5 -2.0 1.8 0.2
Type 2 Diabetes (T2D) (2018) 1.3 2.4 5.2 -1.1 -1.0 1.4 2.3
Lung FEV1/FVC ratio 0.5 2.3 8.4 -0.2 -2.9 -0.6 -0.6
Lung FVC 0.3 1.7 4.7 -1.4 0.2 0.6 2.2
Neuroticism 1.5 3.7 5.3 -2.3 -1.0 2.0 2.1
Chronotype (morning person) 0.1 0.3 0.6 0.1 0.3 -0.8 -0.5
Hair Pigment 0.0 1.2 4.2 -0.2 2.0 -0.2 -0.7
Tanning 0.1 1.3 2.4 1.6 0.2 1.0 1.4
Hand grip strength (left) 0.3 0.8 1.4 -0.7 -0.8 -0.7 -1.2
Number of treatments/medications taken 0.8 1.5 3.8 -0.4 -0.8 2.0 1.2
Average weekly spirits intake 0.3 0.4 1.1 -0.6 -1.1 -0.1 -0.4
Sensitivity / hurt feelings 0.7 1.1 2.0 -1.4 -1.2 0.1 1.1
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.3 -0.2 0.6 0.6 0.5
Hearing difficulty/problems: Yes 1.2 1.9 3.8 1.4 1.2 -2.0 -0.6
Relative age of first facial hair 1.2 2.4 6.2 -1.0 2.5 -0.3 1.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.9 -0.4 1.0 -0.2 0.1
Ever used hormone-replacement therapy (HRT) 4.6 5.9 9.6 -2.6 -2.0 3.1 1.8
Ever had hysterectomy (womb removed) 5.2 5.8 9.8 -1.8 -1.3 2.9 3.1
Systolic blood pressure, automated reading 0.9 2.5 7.8 -0.6 -2.8 1.4 -0.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 -0.5 -0.4 0.8 0.5
Angina 1.8 2.4 6.4 -0.8 0.4 1.5 2.5
Medication for hormone replacement therapy 4.1 4.6 6.7 -2.3 -1.3 2.6 2.2
Vitamin and mineral supplements 1.1 1.5 2.7 1.6 1.2 -1.3 0.4
Supplements: Zinc 0.8 0.9 1.6 -1.3 1.0 -0.8 -0.5
Medication: Co-codamol 0.8 0.9 2.3 0.5 1.5 0.9 -0.4
Medication: Metformin 0.6 0.9 2.3 -0.2 -0.1 1.0 1.5
Diabetes (father) 0.4 0.5 1.5 -0.4 0.4 0.2 1.2
Diabetes (mother) 0.5 0.6 1.0 -0.7 -0.2 1.0 1.0
Severe depression (siblings) 0.1 0.1 0.2 -0.5 0.4 0.2 -0.1
Pack years adult smoking proportion 0.6 0.8 1.8 1.3 -1.2 0.0 -0.2
Impedance of leg (right) 0.8 3.8 8.0 -2.3 -2.8 0.8 1.1
Leg fat-free mass (left) 0.3 1.7 2.3 -1.4 -1.5 1.5 0.3
Trunk fat percentage 1.9 7.7 12.0 -2.5 -3.5 3.0 1.9
Hand grip strength (right) 0.1 0.3 1.2 -1.1 -0.1 0.0 -0.0
Townsend deprivation index at recruitment 0.2 0.3 0.6 0.8 0.6 -0.1 0.4
Current tobacco smoking 0.8 1.3 2.5 0.8 -0.9 1.1 1.6
Average weekly fortified wine intake 4.9 5.8 9.5 -2.1 -3.1 2.3 1.9
Maternal smoking around birth 1.4 2.0 3.9 2.0 0.0 -1.3 -1.5
Fed-up feelings 1.6 2.8 4.2 -1.6 -0.8 2.0 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.3 0.2 0.7 -0.5
Relative age voice broke 1.2 1.8 5.7 0.6 2.4 -0.2 1.0
Taking other prescription medications 0.1 0.1 0.3 -0.1 -0.4 0.2 -0.6
Age when periods started (menarche) 0.3 0.7 1.7 0.5 1.3 0.3 0.8
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.5 -0.6 -0.4 1.6 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.2 -0.7 0.3 -0.5 1.1
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.4 0.6 0.0 -0.2 0.2
Qualifications: CSEs or equivalent 5.1 6.7 10.0 -2.6 0.6 3.2 3.1
Serious illness, injury or assault to yourself 1.1 1.3 2.4 1.5 1.3 -1.1 0.1
High blood pressure 0.7 2.1 7.2 0.4 -2.7 0.7 -0.6
Hayfever, allergic rhinitis or eczema 2.6 5.7 13.8 -1.5 -0.7 3.7 2.5
Multivitamins +/- minerals 0.4 0.6 0.9 -0.9 -0.7 0.3 -0.9
Stomach or abdominal pain in last month 0.2 0.3 0.6 0.1 0.5 -0.8 -0.6
Supplements: Glucosamine 0.2 0.2 0.7 -0.3 0.0 -0.8 -0.4
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.7 0.5 0.5 -1.1 -1.6
Medication: Atenolol 0.9 1.1 3.8 1.9 -0.1 -0.5 -0.6
Medication: Levothyroxine sodium 0.7 1.2 2.2 -1.1 -1.1 1.5 0.2
Sitting height 1.4 9.9 16.1 -4.0 -3.9 2.7 1.0
Chronic bronchitis/emphysema (father) 1.4 1.6 4.2 1.0 2.1 1.0 0.3
High blood pressure (mother) 0.6 0.9 1.3 -1.0 -1.1 1.0 0.3
Body mass index (BMI) 0.9 3.9 8.9 -1.2 -1.0 3.0 2.0
Impedance of leg (left) 0.7 3.5 6.6 -2.4 -2.6 0.7 1.1
Leg predicted mass (left) 0.3 1.7 2.3 -1.5 -1.5 1.5 0.4
Trunk fat mass 2.1 9.2 13.0 -2.9 -3.6 3.3 2.1
Waist circumference 0.8 3.0 5.0 -1.5 -1.3 2.2 1.7
Number of incorrect matches in round 1.0 1.7 3.0 1.7 -0.7 -1.0 -1.5
Past tobacco smoking 0.7 1.4 3.3 -1.8 -1.4 0.5 -0.3
Alcohol usually taken with meals 0.3 0.4 0.6 -0.2 0.8 -0.7 -0.7
Nervous feelings 0.7 1.3 4.2 -0.1 -2.0 0.0 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.8 -0.1 -0.3 -0.4 -0.9
Hearing difficulty/problems with background noise 2.0 3.2 5.6 2.1 0.7 -2.4 -1.6
Hair/balding pattern: Pattern 2 1.2 1.6 3.0 -1.1 -1.7 1.0 1.0
Had menopause 2.6 3.2 4.1 -1.6 -1.8 2.0 1.8
Had other major operations 2.8 3.5 5.0 -2.1 -2.2 2.0 0.9
Forced vital capacity (FVC) 0.6 2.4 6.1 -2.5 -1.6 0.6 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.8 0.1 1.3 -0.8 1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.4 0.3 -0.6 -0.7 -0.7
Qualifications: None of the above 0.9 2.0 5.1 -0.4 -0.6 1.5 2.3
Financial difficulties in last 2 years 0.7 0.9 1.5 -0.2 0.9 1.2 1.1
Mouth/teeth dental problems 0.7 1.0 2.5 -1.0 -0.6 0.5 1.6
Heart attack 1.0 1.3 2.5 1.1 1.6 -1.2 0.0
Allergy 1.3 2.9 6.8 1.0 -0.0 -2.6 -1.9
Pain all over the body in last month 0.1 0.1 0.3 -0.1 0.5 -0.1 -0.5
Diabetes (self-reported) 1.0 1.6 4.4 -0.5 -0.6 1.2 2.1
Hayfever/allergic rhinitis (self-reported) 4.0 5.3 9.1 -3.0 -1.6 2.5 1.9
Medication: Ramipril 0.6 0.7 1.8 -0.5 -1.4 -0.3 -0.8
Medication: Simvastatin 1.9 2.9 6.0 1.8 1.2 -2.5 -0.9
Fluid intelligence score 0.1 0.1 0.4 -0.3 0.1 0.1 -0.6
Illnesses of siblings 3.9 5.4 11.4 2.2 1.0 -2.2 -3.4
Neuroticism score 0.9 2.0 3.0 -1.7 -1.7 0.9 1.2
Weight 1.4 7.0 10.6 -2.8 -2.7 3.3 1.5
Impedance of arm (right) 0.5 2.4 4.1 0.2 -1.5 -2.0 -1.8
Arm fat percentage (right) 1.2 4.6 6.6 -1.7 -2.3 2.6 1.8
Trunk fat-free mass 0.7 4.3 6.1 -2.5 -2.4 2.1 0.7
Hip circumference 0.9 4.1 7.1 -1.8 -1.7 2.7 1.8
Time employed in main current job 0.8 1.0 1.3 0.9 -0.7 -1.1 -1.1
Alcohol intake versus 10 years previously 1.1 1.6 4.6 -1.1 -2.1 0.1 -0.8
Father’s age at death 0.1 0.1 0.4 -0.1 0.6 -0.1 0.3
Worrier / anxious feelings 0.2 0.4 0.8 -0.4 -0.5 0.9 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.1 2.2 -1.0 -1.0 1.5 0.1
Falls in the last year 0.5 0.7 1.4 1.2 1.1 -0.5 -0.3
Hair/balding pattern: Pattern 3 0.6 0.9 1.6 0.2 -1.3 1.1 -0.9
Number of live births 3.0 4.2 9.1 -1.8 1.0 1.9 3.0
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 5.4 -2.3 -1.7 -0.3 0.3
Pulse rate 0.1 0.2 0.5 -0.1 0.5 0.7 0.5
Happiness 0.7 0.9 1.7 -1.3 -0.5 1.2 0.5
Noisy workplace 0.4 0.5 1.0 0.6 0.1 -0.7 -1.0
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.3 0.2 -1.5 -0.4 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.1 0.4 1.1 -0.7 -0.6
Mouth/teeth dental problems: Dentures 1.2 2.0 4.3 1.8 2.1 0.1 -0.5
Asthma 0.1 0.3 0.7 -0.4 -0.3 0.8 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.8 0.9 -0.6 0.3 -0.3
Medication: Cholesterol lowering 1.3 2.0 5.3 2.3 1.3 -0.8 0.5
Depression (self-reported) 0.2 0.2 0.5 0.7 0.2 -0.5 -0.5
Medication: Lansoprazole 5.5 6.2 12.3 -2.3 -1.1 2.5 3.5
Prospective memory result 0.5 0.6 1.0 -0.4 -1.0 0.8 0.9
Lung cancer (father) 1.3 1.5 3.9 -0.3 -2.0 1.4 0.3
Illnesses of mother 1.8 2.3 5.8 1.0 0.0 -2.4 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 4.1 -2.0 -1.7 -0.2 0.2
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 -0.9 -0.5 0.6 0.3
Impedance of arm (left) 0.6 2.6 5.3 0.5 -1.1 -2.3 -1.9
Arm fat mass (right) 2.0 8.4 11.7 -2.8 -2.9 3.4 2.3
Trunk predicted mass 0.8 4.4 6.1 -2.5 -2.5 2.2 0.8
Standing height 0.8 8.4 18.1 -3.7 -4.2 1.2 -0.8
Length of working week for main job 1.1 1.2 3.2 0.6 0.7 -1.8 -0.8
Exposure to tobacco smoke at home 1.4 1.6 2.1 1.4 1.1 -1.4 -1.1
Breastfed as a baby 2.2 2.7 4.5 2.0 0.2 -2.1 -1.5
Tense / ‘highly strung’ 0.1 0.2 0.5 0.4 -0.2 -0.7 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 1.9 -1.4 -1.4 0.8 0.4
Hair/balding pattern: Pattern 4 0.3 0.8 2.2 0.5 -1.5 0.2 -0.9
Birth weight of first child 0.8 1.5 5.2 -0.3 -2.3 0.8 0.5
Peak expiratory flow (PEF) 0.5 1.1 2.1 -1.5 -0.5 -1.3 -0.5
Pulse wave reflection index 0.2 0.3 0.8 -0.0 -0.0 -0.6 -0.9
Ever highly irritable/argumentative for 2 days 1.7 2.1 6.2 -0.9 -0.0 1.2 2.5
Loud music exposure frequency 0.4 0.4 0.7 0.5 0.2 -0.8 -0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.7 -0.5 -0.8 -0.7 -1.3
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.1 0.6 -1.3 -0.7 -1.4
Blood clot in the leg (DVT) 1.7 2.2 4.4 2.1 2.0 -0.2 0.6
Medication: Paracetamol 0.4 0.7 1.6 0.0 0.5 1.3 0.9
Headache pain in last month 0.8 1.4 4.2 0.5 2.0 -1.1 -0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 -1.2 0.0 0.3 0.1
Glaucoma (self-reported) 0.8 1.0 2.8 -0.0 0.3 1.1 1.7
Gout (self-reported) 3.0 4.1 9.5 3.1 0.6 -1.7 -1.9
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 3.8 -1.6 -1.3 2.0 1.0
Medication: Amlodipine 0.9 1.3 4.0 -0.6 -2.0 0.9 -0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.4 0.0 -0.4 -0.7 -1.2
Birth weight 0.6 1.3 3.1 -1.4 -1.8 -0.0 0.3
Chronic bronchitis/emphysema (mother) 1.5 1.8 4.4 -0.4 0.3 2.1 1.6
High blood pressure (siblings) 3.3 4.8 9.7 -1.6 -0.8 2.5 3.1
Forced vital capacity (FVC), Best measure 0.3 1.2 3.5 -1.9 -0.9 0.2 0.6
Body fat percentage 2.3 9.1 12.5 -2.7 -3.2 3.5 2.6
Leg fat percentage (right) 3.1 11.2 16.9 -2.9 -3.0 4.1 3.3
Arm fat-free mass (right) 1.5 7.6 9.9 -3.1 -3.0 3.0 1.6
Exposure to tobacco smoke outside home 0.1 0.2 0.3 -0.5 0.2 -0.2 -0.5
Comparative body size at age 10 0.4 1.1 2.3 1.2 -0.1 -1.5 -0.8
Number of full brothers 0.8 1.0 2.2 0.8 1.5 0.0 1.1
Worry too long after embarrassment 0.7 1.2 2.3 0.4 0.3 -1.5 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.8 0.1 -1.4 -1.3 -0.7
Wheeze or whistling in the chest in last year 0.8 1.4 5.0 2.2 0.4 0.2 0.8
Number of children fathered 1.0 1.1 1.7 -1.1 0.7 0.9 1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.0 -0.7 1.0 -0.8 -0.1
Age at first live birth 0.2 0.4 1.3 -1.1 0.1 0.4 0.0
Pulse wave peak to peak time 0.3 0.3 0.6 0.7 0.2 -0.6 -0.5
Health satisfaction 2.0 2.6 4.8 -2.2 -1.1 1.6 1.3
Shortness of breath walking on level ground 0.6 0.8 1.3 -0.9 0.8 -0.6 -1.1
Qualifications: College or University degree 1.3 4.1 7.2 1.7 1.4 -2.1 -2.7
Eye problems/disorders: None of the above 2.0 2.4 4.2 1.1 -0.9 -1.8 -2.0
Mouth/teeth dental problems: Loose teeth 2.1 2.5 7.0 0.4 -1.1 -1.2 -2.6
Emphysema/chronic bronchitis 0.1 0.2 0.3 -0.6 0.4 0.4 -0.3
Medication for pain relief, constipation, heartburn 0.6 1.1 2.5 -0.0 -0.2 -1.6 -1.3
Neck or shoulder pain in last month 0.7 1.0 1.9 -1.4 -0.7 1.1 0.7
Medication: Blood pressure 0.3 0.5 0.8 0.9 -0.9 -0.3 -0.6
Angina (self-reported) 1.8 2.4 6.4 -0.8 0.6 1.5 2.5
Migraine (self-reported) 0.3 0.4 0.9 -0.4 -0.9 -0.6 -0.3
Medication: Ibuprofen 0.2 0.3 0.6 0.5 -0.6 0.7 -0.2
Medication: Allopurinol 1.6 2.1 6.4 2.5 0.3 -1.0 -1.1
Medication: Omeprazole 0.5 0.6 1.6 0.2 1.3 0.6 0.5
Medication: Seretide 50 evohaler 1.3 1.5 3.7 1.2 1.9 -0.6 -0.8
Mean time to correctly identify matches 0.7 1.4 3.8 -0.2 -1.9 1.3 -0.2
Heart disease (mother) 0.7 0.9 2.0 -0.5 -1.1 1.4 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 5.1 0.7 -0.5 -1.8 -2.3
Whole body fat mass 2.3 9.5 12.3 -3.0 -3.3 3.5 2.4
Leg fat mass (right) 2.8 10.7 15.3 -3.2 -3.0 3.9 2.9
Arm predicted mass (right) 1.5 7.5 10.5 -3.2 -2.7 3.1 1.6
Pulse rate, automated reading 0.3 0.8 2.1 -0.4 -0.5 1.4 0.9
Alcohol intake frequency. 3.0 7.0 21.6 -4.7 -1.9 1.7 0.3
Comparative height size at age 10 1.0 5.8 17.3 -0.5 -4.2 0.3 -2.3
Number of full sisters 2.4 3.0 6.2 -1.6 1.6 0.6 2.5
Suffer from ‘nerves’ 1.1 1.7 5.9 -0.7 -2.4 0.4 -0.5
Overall health rating 0.3 0.6 1.5 0.5 0.2 1.2 0.9
Chest pain or discomfort 0.3 0.5 1.1 -1.0 -0.5 -0.5 -0.7
Had major operations 1.4 1.7 4.2 1.1 2.0 -1.1 0.1
Age at last live birth 1.1 1.6 2.2 -1.5 -0.8 1.4 1.3
Family relationship satisfaction 0.6 0.8 1.6 -1.2 -0.9 0.9 0.2
Leg pain on walking 0.5 0.7 2.0 -0.1 -0.4 -0.8 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.8 0.4 1.7 -1.0 -0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.8 -0.6 0.9 -0.5 0.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 4.6 -1.3 -2.1 0.6 0.1
Medication: Aspirin 1.3 1.7 3.7 -0.5 1.1 1.3 1.9
Supplements: Vitamin C 2.7 3.2 5.0 -2.1 0.6 2.2 1.8
Knee pain experienced in last month 1.1 1.7 3.6 -1.9 -1.5 0.8 -0.6
Hypertension (Self-reported) 0.7 1.9 6.4 0.4 -2.5 0.9 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 2.6 1.4 1.6 1.1 0.7
Illnesses of father: Heart disease 1.3 1.8 5.1 -0.2 0.7 1.2 2.3
Illnesses of siblings: Diabetes 3.6 4.4 7.3 -2.7 -1.7 1.1 2.5
Smoking status: Previous 0.4 0.7 1.3 1.0 1.1 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.3 -1.4 -1.8 -0.1 -0.7
Whole body fat-free mass 0.7 3.9 5.6 -2.4 -2.3 2.1 0.7
Leg fat-free mass (right) 0.2 0.9 1.6 -1.2 -0.9 1.1 -0.0
Arm fat percentage (left) 1.0 4.2 6.0 -1.7 -2.1 2.4 1.9
Average weekly red wine intake 0.4 0.5 0.9 0.9 -0.3 -0.6 -0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.1 0.9 0.8 -1.0 -0.5
Mood swings 0.9 1.6 3.0 -1.7 -1.0 0.7 1.4
Loneliness, isolation 1.6 2.3 4.8 -1.8 -2.2 0.9 -0.1
Long-standing illness, disability or infirmity 0.9 1.3 3.4 0.3 1.0 -1.9 -1.0
Ever had bowel cancer screening 0.1 0.1 0.3 -0.0 -0.5 0.3 0.5
Diabetes diagnosed by doctor 2.3 3.8 9.4 -1.4 -0.4 1.9 3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 -0.7 -0.0 0.5 0.8
Friendships satisfaction 2.6 3.2 6.6 -1.5 -2.6 1.9 0.6
Qualifications: nursing, teaching 0.5 0.8 1.8 1.4 0.7 -0.6 -0.6
Commuting to job workplace: Walk 0.5 0.5 0.8 0.7 0.6 0.6 0.9
Eye problems/disorders: Cataract 0.8 0.9 1.6 -1.1 1.3 0.1 0.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.6 -0.8 0.6 -0.4 -0.5
Medication for cholesterol 0.3 0.4 0.9 0.4 0.3 -0.7 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 0.0 -1.3 0.4 -0.6
Back pain experienced in last month 0.3 0.5 0.9 0.6 0.1 -1.0 -0.8
Mineral and other dietary supplements 0.7 0.9 2.3 1.5 0.1 -1.0 -0.6
Breast cancer (self-reported) 1.5 1.8 3.2 0.8 1.7 0.8 1.8
Asthma (self-reported) 0.2 0.4 1.2 -0.6 -0.5 1.1 -0.0
Osteoporosis (self-reported) 0.5 0.6 1.5 0.1 1.2 0.8 0.3
Osteoarthritis (self-reported) 1.4 1.8 4.1 -2.0 -0.8 1.3 0.8
Medication: Aspirin 2.2 2.9 6.1 -0.3 1.5 1.7 2.5
Medication: Gliclazide 0.4 0.5 0.9 0.5 -0.9 0.3 -0.8
Illnesses of father: None of the above (group 1) 1.1 1.4 2.7 -1.6 -0.5 -0.4 -1.6
Smoking status: Current 0.9 1.5 2.9 0.9 -0.8 1.2 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.1 -0.6 0.1 -0.2 1.4
Whole body water mass 0.7 4.0 5.3 -2.3 -2.2 2.3 0.8
Leg predicted mass (right) 0.2 0.9 1.5 -1.2 -0.9 1.1 -0.0
Arm fat mass (left) 1.7 6.9 9.7 -2.6 -2.6 3.1 2.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.7 0.2 -0.4 0.8 0.4
Average weekly champagne plus white wine intake 1.5 2.1 6.5 2.5 1.3 -0.4 0.2
Miserableness 1.0 1.8 2.8 -1.5 -0.9 1.1 1.7
Guilty feelings 0.3 0.4 1.1 -0.6 0.1 -1.0 0.4
Wears glasses or contact lenses 0.5 0.5 1.3 0.8 1.1 0.5 0.1
Ever taken oral contraceptive pill 0.6 0.7 1.3 0.8 1.1 -0.9 -0.1
Hearing aid user 0.4 0.4 1.3 0.6 0.0 -1.1 -0.3
Mother’s age at death 0.2 0.3 0.8 -0.9 -0.1 0.2 0.4
Financial situation satisfaction 0.6 0.7 1.2 -0.7 -0.4 1.0 1.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.6 -1.3 -0.8 1.6 0.8
Commuting to job workplace: Public transport 2.1 2.5 4.3 1.9 0.8 -2.1 -1.1
Eye problems/disorders: Glaucoma 0.6 0.8 1.3 0.6 1.1 0.1 1.1
Medication: Blood pressure 0.3 0.6 2.2 -0.2 -1.5 0.6 -0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.5 0.2 0.4 -1.6 -0.9
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.7 -1.0 0.2 1.6 0.6
High cholesterol (Self-reported) 0.8 1.4 3.6 1.9 1.2 -0.7 0.3
Medication: Bendroflumethiazide 0.6 0.8 3.3 -0.1 -1.8 0.2 -0.1
Medication: Paracetamol 0.9 1.4 3.7 -0.3 -0.2 1.9 1.2
Medication: Lisinopril 0.3 0.4 1.1 0.7 -0.3 1.1 0.2
Medication: Atorvastatin 1.4 1.8 3.5 0.9 1.7 0.0 1.9
Illnesses of father: High blood pressure 0.6 0.7 0.9 0.7 -0.9 0.9 0.8
Alcohol drinker status: Never 0.5 0.6 1.6 -1.3 0.5 -0.7 -0.4
Ever smoked 0.8 1.4 3.8 2.0 1.2 -0.3 0.3
Basal metabolic rate 0.9 4.9 7.0 -2.6 -2.4 2.5 1.0
Leg fat percentage (left) 2.6 9.6 13.9 -2.6 -2.8 3.7 3.1
Arm fat-free mass (left) 1.5 7.8 11.6 -3.0 -2.8 3.4 1.7
Number of operations (self-reported) 0.5 0.7 1.0 -0.8 -0.8 0.7 1.0
Average weekly beer plus cider intake 0.5 0.7 2.0 1.4 0.2 -0.8 -0.3
Irritability 0.2 0.4 0.7 -0.8 -0.5 0.8 0.4
Risk taking 0.3 0.4 0.9 0.6 1.0 -0.5 -0.1
Ever had prostate specific antigen (PSA) test 2.0 2.3 3.6 1.3 0.8 -1.8 -1.9
Fractured/broken bones in last 5 years 0.7 0.8 2.0 0.2 0.1 -1.4 -1.1
Age started oral contraceptive pill 1.5 1.9 3.3 -0.6 -1.3 1.8 1.5
Diastolic blood pressure, automated reading 1.1 3.4 7.7 -0.9 -2.8 2.2 0.3
Ever depressed for a whole week 0.4 0.5 1.2 1.1 0.6 -0.6 0.2
Unable to work because of sickness or disability 0.5 0.6 1.0 0.4 -0.9 -1.0 -0.7
Commuting to job workplace: Cycle 0.2 0.3 0.6 -0.6 -0.8 0.2 -0.2
Myopia 3.0 4.4 8.6 -1.9 -1.8 2.9 1.5
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.2 -0.4 2.0 -0.9 0.1
Cholesterol lowering medication 0.9 1.3 1.9 1.4 1.3 -1.2 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.4 0.2 1.2 0.4 0.2
Pain experienced in last month 0.3 0.5 1.2 1.1 0.5 0.4 0.5
Supplements: Calcium 0.2 0.2 0.5 -0.4 -0.2 0.3 -0.7
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 -1.4 0.5 0.1 0.6
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.1 1.2 1.8 -1.5 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 3.8 2.0 1.9 0.1 0.8
Heart disease (siblings) 1.0 1.2 2.2 -0.7 -1.2 0.8 1.5
Alcohol drinker status: Previous 0.5 0.6 1.5 -0.7 -0.2 -1.2 -0.4
Pack years of smoking 0.7 1.0 2.3 1.5 -1.3 0.1 -0.2
Impedance of whole body 0.3 1.5 4.1 -0.8 -2.0 -1.0 -0.7
Leg fat mass (left) 2.5 9.8 13.9 -3.0 -2.9 3.7 2.8
Arm predicted mass (left) 1.7 8.5 11.4 -3.4 -2.8 3.4 1.8