Hub : Genes

LBH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0360	0.00160	0.028	0.037	0.040	0.043	0.031	1.9e-04	2.5e-05	1.1e-05	4.6e-06	1.0e-04
2	GTEx	Skin Sun Exposed Lower leg	0.1130	0.0410	0.00220	0.005	NA	0.009	NA	0.004	1.2e-01	NA	5.8e-02	NA	1.5e-01
3	NTR	Blood	0.0261	0.0089	0.00021	0.016	0.013	0.018	0.013	0.010	5.9e-06	3.2e-05	1.5e-06	3.2e-05	2.2e-04
4	YFS	Blood	0.2170	0.0309	0.00000	0.089	0.125	0.136	0.129	0.110	1.3e-27	1.5e-38	3.1e-42	5.6e-40	6.2e-34

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.9	0.9	0.0	0.3	-0.5
Bipolar Disorder or Schizophrenia	0.5	1.3	3.9	-0.1	2.0	0.8	0.9
Depressed Affect (Nagel 2018)	2.0	4.2	6.6	-2.6	-1.9	1.9	1.8
Depression (Nagel 2018)	1.0	1.6	2.9	-1.7	0.3	1.7	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	-0.8	-0.0	-0.8	-0.9
Neuroticism (Nagel 2018)	0.9	2.0	3.0	-1.7	-1.6	1.3	1.0
Schizophrenia (2018)	1.2	2.5	6.3	-0.8	2.5	0.8	1.5
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	-1.5	0.6	0.3	0.7
Worry (Nagel 2018)	0.3	0.6	1.6	-0.8	-1.2	0.4	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	-0.5	0.5	0.7	0.6
Alzheimer’s Disease (in father)	0.8	0.9	1.9	-1.1	-1.4	-0.6	-0.0
Alzheimer’s Disease (including proxy)	0.8	1.2	2.8	-1.7	-0.8	0.7	1.0
Crohns Disease (2017)	2.7	5.9	7.9	-2.8	-0.5	2.8	2.8
Irritable Bowel Disease (IBD)	1.9	4.4	7.1	-2.7	1.0	2.0	2.4
Ulcerative Colitis (UC)	1.3	2.4	4.6	-1.6	2.1	0.5	1.5
Major Depression (MDD)	0.7	0.9	1.4	-0.9	1.2	0.5	1.1
Reaction Time	0.1	0.2	0.6	0.2	-0.4	0.8	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	-1.2	-0.7	-0.1	-0.9
Breast Cancer	0.6	1.4	3.8	0.3	1.9	-1.0	-0.9
Ovarian Cancer	0.7	0.9	1.6	-1.3	-0.6	1.1	0.5
Prostate Cancer	0.1	0.2	0.3	-0.6	-0.2	-0.5	-0.4
Age at First Birth	1.1	1.6	3.2	-1.7	1.8	-0.5	0.4
Bipolar Disorder (2011)	0.8	0.7	1.9	-1.4	-0.3	0.9	0.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	0.3	0.4	1.5	0.9
Coronary Artery Disease (CAD)	0.6	0.7	1.2	-0.9	-1.1	0.8	0.5
Crohns Disease (2012)	1.2	1.9	3.6	-1.9	-1.1	1.5	0.6
Mean Putamen Volume	0.2	0.3	0.4	0.2	0.6	0.5	-0.7
Fasting Glucose	0.8	0.9	1.4	0.7	-1.0	0.9	1.2
HbA1C	0.5	0.6	1.5	-1.2	-0.8	0.2	0.1
HDL Cholesterol	1.3	2.1	4.5	1.2	-0.1	-2.1	-1.6
LDL Cholesterol	0.3	0.4	0.6	-0.3	0.8	0.8	0.6
Lupus	1.0	1.4	3.1	0.6	1.8	-0.2	1.5
Neuroticism (2016)	0.8	1.1	2.8	-1.7	-0.8	0.1	1.0
Primary Biliary Cirrhosis	2.6	3.7	10.7	-0.6	-1.2	3.3	1.5
Rheumatoid Arthritis	0.2	0.3	0.9	-0.2	0.3	0.3	0.9
Schizophrenia (2014)	1.1	2.5	5.7	-1.3	2.4	1.1	1.2
Triglycerides	0.6	1.0	2.1	0.2	0.1	1.3	1.4
Type 2 Diabetes (T2D) (2012)	2.6	3.0	6.6	-0.9	-1.0	2.6	1.9
Ulcerative Colitis	0.7	1.0	2.6	-1.6	0.8	0.7	0.6
Blood Eosinophil Count	0.0	0.3	1.0	0.5	-0.0	1.0	-0.4
Blood Platelet Count	0.2	2.7	5.2	-0.3	0.7	2.2	2.3
Blood Red Count	0.2	1.9	3.7	1.9	1.9	0.4	0.4
Blood White Count	0.6	4.8	13.8	3.7	2.1	0.1	1.0
Heel T-Score	0.2	1.5	3.7	-1.9	0.3	-1.1	1.0
BMI	1.0	5.8	9.5	-2.1	-1.0	3.1	2.9
Height	0.8	15.8	36.0	-4.5	-6.0	2.5	0.9
Waist Hip Ratio (WHR)	0.3	1.2	3.3	-0.5	0.5	0.9	1.8
Systolic Blood Pressure	0.2	0.9	2.2	0.2	-1.5	-0.1	-1.1
Smoking Status	0.4	0.9	2.6	1.6	0.4	0.1	0.9
Allergy or Eczema	1.9	4.9	13.9	-0.9	-0.4	3.7	2.2
Cardiovascular Disease	0.5	1.7	3.5	-0.2	-1.9	1.7	0.6
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.6	-0.8	0.6	-0.1
Respiratory disease	1.1	2.4	4.1	-1.5	-2.0	1.8	0.2
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.2	-1.1	-1.0	1.4	2.3
Lung FEV1/FVC ratio	0.5	2.3	8.4	-0.2	-2.9	-0.6	-0.6
Lung FVC	0.3	1.7	4.7	-1.4	0.2	0.6	2.2
Neuroticism	1.5	3.7	5.3	-2.3	-1.0	2.0	2.1
Chronotype (morning person)	0.1	0.3	0.6	0.1	0.3	-0.8	-0.5
Hair Pigment	0.0	1.2	4.2	-0.2	2.0	-0.2	-0.7
Tanning	0.1	1.3	2.4	1.6	0.2	1.0	1.4
Hand grip strength (left)	0.3	0.8	1.4	-0.7	-0.8	-0.7	-1.2
Number of treatments/medications taken	0.8	1.5	3.8	-0.4	-0.8	2.0	1.2
Average weekly spirits intake	0.3	0.4	1.1	-0.6	-1.1	-0.1	-0.4
Sensitivity / hurt feelings	0.7	1.1	2.0	-1.4	-1.2	0.1	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	-0.2	0.6	0.6	0.5
Hearing difficulty/problems: Yes	1.2	1.9	3.8	1.4	1.2	-2.0	-0.6
Relative age of first facial hair	1.2	2.4	6.2	-1.0	2.5	-0.3	1.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	-0.4	1.0	-0.2	0.1
Ever used hormone-replacement therapy (HRT)	4.6	5.9	9.6	-2.6	-2.0	3.1	1.8
Ever had hysterectomy (womb removed)	5.2	5.8	9.8	-1.8	-1.3	2.9	3.1
Systolic blood pressure, automated reading	0.9	2.5	7.8	-0.6	-2.8	1.4	-0.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.5	-0.4	0.8	0.5
Angina	1.8	2.4	6.4	-0.8	0.4	1.5	2.5
Medication for hormone replacement therapy	4.1	4.6	6.7	-2.3	-1.3	2.6	2.2
Vitamin and mineral supplements	1.1	1.5	2.7	1.6	1.2	-1.3	0.4
Supplements: Zinc	0.8	0.9	1.6	-1.3	1.0	-0.8	-0.5
Medication: Co-codamol	0.8	0.9	2.3	0.5	1.5	0.9	-0.4
Medication: Metformin	0.6	0.9	2.3	-0.2	-0.1	1.0	1.5
Diabetes (father)	0.4	0.5	1.5	-0.4	0.4	0.2	1.2
Diabetes (mother)	0.5	0.6	1.0	-0.7	-0.2	1.0	1.0
Severe depression (siblings)	0.1	0.1	0.2	-0.5	0.4	0.2	-0.1
Pack years adult smoking proportion	0.6	0.8	1.8	1.3	-1.2	0.0	-0.2
Impedance of leg (right)	0.8	3.8	8.0	-2.3	-2.8	0.8	1.1
Leg fat-free mass (left)	0.3	1.7	2.3	-1.4	-1.5	1.5	0.3
Trunk fat percentage	1.9	7.7	12.0	-2.5	-3.5	3.0	1.9
Hand grip strength (right)	0.1	0.3	1.2	-1.1	-0.1	0.0	-0.0
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.8	0.6	-0.1	0.4
Current tobacco smoking	0.8	1.3	2.5	0.8	-0.9	1.1	1.6
Average weekly fortified wine intake	4.9	5.8	9.5	-2.1	-3.1	2.3	1.9
Maternal smoking around birth	1.4	2.0	3.9	2.0	0.0	-1.3	-1.5
Fed-up feelings	1.6	2.8	4.2	-1.6	-0.8	2.0	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.3	0.2	0.7	-0.5
Relative age voice broke	1.2	1.8	5.7	0.6	2.4	-0.2	1.0
Taking other prescription medications	0.1	0.1	0.3	-0.1	-0.4	0.2	-0.6
Age when periods started (menarche)	0.3	0.7	1.7	0.5	1.3	0.3	0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.5	-0.6	-0.4	1.6	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.2	-0.7	0.3	-0.5	1.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.6	0.0	-0.2	0.2
Qualifications: CSEs or equivalent	5.1	6.7	10.0	-2.6	0.6	3.2	3.1
Serious illness, injury or assault to yourself	1.1	1.3	2.4	1.5	1.3	-1.1	0.1
High blood pressure	0.7	2.1	7.2	0.4	-2.7	0.7	-0.6
Hayfever, allergic rhinitis or eczema	2.6	5.7	13.8	-1.5	-0.7	3.7	2.5
Multivitamins +/- minerals	0.4	0.6	0.9	-0.9	-0.7	0.3	-0.9
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.1	0.5	-0.8	-0.6
Supplements: Glucosamine	0.2	0.2	0.7	-0.3	0.0	-0.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.7	0.5	0.5	-1.1	-1.6
Medication: Atenolol	0.9	1.1	3.8	1.9	-0.1	-0.5	-0.6
Medication: Levothyroxine sodium	0.7	1.2	2.2	-1.1	-1.1	1.5	0.2
Sitting height	1.4	9.9	16.1	-4.0	-3.9	2.7	1.0
Chronic bronchitis/emphysema (father)	1.4	1.6	4.2	1.0	2.1	1.0	0.3
High blood pressure (mother)	0.6	0.9	1.3	-1.0	-1.1	1.0	0.3
Body mass index (BMI)	0.9	3.9	8.9	-1.2	-1.0	3.0	2.0
Impedance of leg (left)	0.7	3.5	6.6	-2.4	-2.6	0.7	1.1
Leg predicted mass (left)	0.3	1.7	2.3	-1.5	-1.5	1.5	0.4
Trunk fat mass	2.1	9.2	13.0	-2.9	-3.6	3.3	2.1
Waist circumference	0.8	3.0	5.0	-1.5	-1.3	2.2	1.7
Number of incorrect matches in round	1.0	1.7	3.0	1.7	-0.7	-1.0	-1.5
Past tobacco smoking	0.7	1.4	3.3	-1.8	-1.4	0.5	-0.3
Alcohol usually taken with meals	0.3	0.4	0.6	-0.2	0.8	-0.7	-0.7
Nervous feelings	0.7	1.3	4.2	-0.1	-2.0	0.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	-0.1	-0.3	-0.4	-0.9
Hearing difficulty/problems with background noise	2.0	3.2	5.6	2.1	0.7	-2.4	-1.6
Hair/balding pattern: Pattern 2	1.2	1.6	3.0	-1.1	-1.7	1.0	1.0
Had menopause	2.6	3.2	4.1	-1.6	-1.8	2.0	1.8
Had other major operations	2.8	3.5	5.0	-2.1	-2.2	2.0	0.9
Forced vital capacity (FVC)	0.6	2.4	6.1	-2.5	-1.6	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.8	0.1	1.3	-0.8	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.4	0.3	-0.6	-0.7	-0.7
Qualifications: None of the above	0.9	2.0	5.1	-0.4	-0.6	1.5	2.3
Financial difficulties in last 2 years	0.7	0.9	1.5	-0.2	0.9	1.2	1.1
Mouth/teeth dental problems	0.7	1.0	2.5	-1.0	-0.6	0.5	1.6
Heart attack	1.0	1.3	2.5	1.1	1.6	-1.2	0.0
Allergy	1.3	2.9	6.8	1.0	-0.0	-2.6	-1.9
Pain all over the body in last month	0.1	0.1	0.3	-0.1	0.5	-0.1	-0.5
Diabetes (self-reported)	1.0	1.6	4.4	-0.5	-0.6	1.2	2.1
Hayfever/allergic rhinitis (self-reported)	4.0	5.3	9.1	-3.0	-1.6	2.5	1.9
Medication: Ramipril	0.6	0.7	1.8	-0.5	-1.4	-0.3	-0.8
Medication: Simvastatin	1.9	2.9	6.0	1.8	1.2	-2.5	-0.9
Fluid intelligence score	0.1	0.1	0.4	-0.3	0.1	0.1	-0.6
Illnesses of siblings	3.9	5.4	11.4	2.2	1.0	-2.2	-3.4
Neuroticism score	0.9	2.0	3.0	-1.7	-1.7	0.9	1.2
Weight	1.4	7.0	10.6	-2.8	-2.7	3.3	1.5
Impedance of arm (right)	0.5	2.4	4.1	0.2	-1.5	-2.0	-1.8
Arm fat percentage (right)	1.2	4.6	6.6	-1.7	-2.3	2.6	1.8
Trunk fat-free mass	0.7	4.3	6.1	-2.5	-2.4	2.1	0.7
Hip circumference	0.9	4.1	7.1	-1.8	-1.7	2.7	1.8
Time employed in main current job	0.8	1.0	1.3	0.9	-0.7	-1.1	-1.1
Alcohol intake versus 10 years previously	1.1	1.6	4.6	-1.1	-2.1	0.1	-0.8
Father’s age at death	0.1	0.1	0.4	-0.1	0.6	-0.1	0.3
Worrier / anxious feelings	0.2	0.4	0.8	-0.4	-0.5	0.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	2.2	-1.0	-1.0	1.5	0.1
Falls in the last year	0.5	0.7	1.4	1.2	1.1	-0.5	-0.3
Hair/balding pattern: Pattern 3	0.6	0.9	1.6	0.2	-1.3	1.1	-0.9
Number of live births	3.0	4.2	9.1	-1.8	1.0	1.9	3.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.4	-2.3	-1.7	-0.3	0.3
Pulse rate	0.1	0.2	0.5	-0.1	0.5	0.7	0.5
Happiness	0.7	0.9	1.7	-1.3	-0.5	1.2	0.5
Noisy workplace	0.4	0.5	1.0	0.6	0.1	-0.7	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.3	0.2	-1.5	-0.4	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.1	0.4	1.1	-0.7	-0.6
Mouth/teeth dental problems: Dentures	1.2	2.0	4.3	1.8	2.1	0.1	-0.5
Asthma	0.1	0.3	0.7	-0.4	-0.3	0.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	0.9	-0.6	0.3	-0.3
Medication: Cholesterol lowering	1.3	2.0	5.3	2.3	1.3	-0.8	0.5
Depression (self-reported)	0.2	0.2	0.5	0.7	0.2	-0.5	-0.5
Medication: Lansoprazole	5.5	6.2	12.3	-2.3	-1.1	2.5	3.5
Prospective memory result	0.5	0.6	1.0	-0.4	-1.0	0.8	0.9
Lung cancer (father)	1.3	1.5	3.9	-0.3	-2.0	1.4	0.3
Illnesses of mother	1.8	2.3	5.8	1.0	0.0	-2.4	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.1	-2.0	-1.7	-0.2	0.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.9	-0.5	0.6	0.3
Impedance of arm (left)	0.6	2.6	5.3	0.5	-1.1	-2.3	-1.9
Arm fat mass (right)	2.0	8.4	11.7	-2.8	-2.9	3.4	2.3
Trunk predicted mass	0.8	4.4	6.1	-2.5	-2.5	2.2	0.8
Standing height	0.8	8.4	18.1	-3.7	-4.2	1.2	-0.8
Length of working week for main job	1.1	1.2	3.2	0.6	0.7	-1.8	-0.8
Exposure to tobacco smoke at home	1.4	1.6	2.1	1.4	1.1	-1.4	-1.1
Breastfed as a baby	2.2	2.7	4.5	2.0	0.2	-2.1	-1.5
Tense / ‘highly strung’	0.1	0.2	0.5	0.4	-0.2	-0.7	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	-1.4	-1.4	0.8	0.4
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	0.5	-1.5	0.2	-0.9
Birth weight of first child	0.8	1.5	5.2	-0.3	-2.3	0.8	0.5
Peak expiratory flow (PEF)	0.5	1.1	2.1	-1.5	-0.5	-1.3	-0.5
Pulse wave reflection index	0.2	0.3	0.8	-0.0	-0.0	-0.6	-0.9
Ever highly irritable/argumentative for 2 days	1.7	2.1	6.2	-0.9	-0.0	1.2	2.5
Loud music exposure frequency	0.4	0.4	0.7	0.5	0.2	-0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.7	-0.5	-0.8	-0.7	-1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.1	0.6	-1.3	-0.7	-1.4
Blood clot in the leg (DVT)	1.7	2.2	4.4	2.1	2.0	-0.2	0.6
Medication: Paracetamol	0.4	0.7	1.6	0.0	0.5	1.3	0.9
Headache pain in last month	0.8	1.4	4.2	0.5	2.0	-1.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-1.2	0.0	0.3	0.1
Glaucoma (self-reported)	0.8	1.0	2.8	-0.0	0.3	1.1	1.7
Gout (self-reported)	3.0	4.1	9.5	3.1	0.6	-1.7	-1.9
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.8	-1.6	-1.3	2.0	1.0
Medication: Amlodipine	0.9	1.3	4.0	-0.6	-2.0	0.9	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.0	-0.4	-0.7	-1.2
Birth weight	0.6	1.3	3.1	-1.4	-1.8	-0.0	0.3
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.4	-0.4	0.3	2.1	1.6
High blood pressure (siblings)	3.3	4.8	9.7	-1.6	-0.8	2.5	3.1
Forced vital capacity (FVC), Best measure	0.3	1.2	3.5	-1.9	-0.9	0.2	0.6
Body fat percentage	2.3	9.1	12.5	-2.7	-3.2	3.5	2.6
Leg fat percentage (right)	3.1	11.2	16.9	-2.9	-3.0	4.1	3.3
Arm fat-free mass (right)	1.5	7.6	9.9	-3.1	-3.0	3.0	1.6
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.5	0.2	-0.2	-0.5
Comparative body size at age 10	0.4	1.1	2.3	1.2	-0.1	-1.5	-0.8
Number of full brothers	0.8	1.0	2.2	0.8	1.5	0.0	1.1
Worry too long after embarrassment	0.7	1.2	2.3	0.4	0.3	-1.5	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.8	0.1	-1.4	-1.3	-0.7
Wheeze or whistling in the chest in last year	0.8	1.4	5.0	2.2	0.4	0.2	0.8
Number of children fathered	1.0	1.1	1.7	-1.1	0.7	0.9	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.7	1.0	-0.8	-0.1
Age at first live birth	0.2	0.4	1.3	-1.1	0.1	0.4	0.0
Pulse wave peak to peak time	0.3	0.3	0.6	0.7	0.2	-0.6	-0.5
Health satisfaction	2.0	2.6	4.8	-2.2	-1.1	1.6	1.3
Shortness of breath walking on level ground	0.6	0.8	1.3	-0.9	0.8	-0.6	-1.1
Qualifications: College or University degree	1.3	4.1	7.2	1.7	1.4	-2.1	-2.7
Eye problems/disorders: None of the above	2.0	2.4	4.2	1.1	-0.9	-1.8	-2.0
Mouth/teeth dental problems: Loose teeth	2.1	2.5	7.0	0.4	-1.1	-1.2	-2.6
Emphysema/chronic bronchitis	0.1	0.2	0.3	-0.6	0.4	0.4	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	-0.0	-0.2	-1.6	-1.3
Neck or shoulder pain in last month	0.7	1.0	1.9	-1.4	-0.7	1.1	0.7
Medication: Blood pressure	0.3	0.5	0.8	0.9	-0.9	-0.3	-0.6
Angina (self-reported)	1.8	2.4	6.4	-0.8	0.6	1.5	2.5
Migraine (self-reported)	0.3	0.4	0.9	-0.4	-0.9	-0.6	-0.3
Medication: Ibuprofen	0.2	0.3	0.6	0.5	-0.6	0.7	-0.2
Medication: Allopurinol	1.6	2.1	6.4	2.5	0.3	-1.0	-1.1
Medication: Omeprazole	0.5	0.6	1.6	0.2	1.3	0.6	0.5
Medication: Seretide 50 evohaler	1.3	1.5	3.7	1.2	1.9	-0.6	-0.8
Mean time to correctly identify matches	0.7	1.4	3.8	-0.2	-1.9	1.3	-0.2
Heart disease (mother)	0.7	0.9	2.0	-0.5	-1.1	1.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	5.1	0.7	-0.5	-1.8	-2.3
Whole body fat mass	2.3	9.5	12.3	-3.0	-3.3	3.5	2.4
Leg fat mass (right)	2.8	10.7	15.3	-3.2	-3.0	3.9	2.9
Arm predicted mass (right)	1.5	7.5	10.5	-3.2	-2.7	3.1	1.6
Pulse rate, automated reading	0.3	0.8	2.1	-0.4	-0.5	1.4	0.9
Alcohol intake frequency.	3.0	7.0	21.6	-4.7	-1.9	1.7	0.3
Comparative height size at age 10	1.0	5.8	17.3	-0.5	-4.2	0.3	-2.3
Number of full sisters	2.4	3.0	6.2	-1.6	1.6	0.6	2.5
Suffer from ‘nerves’	1.1	1.7	5.9	-0.7	-2.4	0.4	-0.5
Overall health rating	0.3	0.6	1.5	0.5	0.2	1.2	0.9
Chest pain or discomfort	0.3	0.5	1.1	-1.0	-0.5	-0.5	-0.7
Had major operations	1.4	1.7	4.2	1.1	2.0	-1.1	0.1
Age at last live birth	1.1	1.6	2.2	-1.5	-0.8	1.4	1.3
Family relationship satisfaction	0.6	0.8	1.6	-1.2	-0.9	0.9	0.2
Leg pain on walking	0.5	0.7	2.0	-0.1	-0.4	-0.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.8	0.4	1.7	-1.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	-0.6	0.9	-0.5	0.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.6	-1.3	-2.1	0.6	0.1
Medication: Aspirin	1.3	1.7	3.7	-0.5	1.1	1.3	1.9
Supplements: Vitamin C	2.7	3.2	5.0	-2.1	0.6	2.2	1.8
Knee pain experienced in last month	1.1	1.7	3.6	-1.9	-1.5	0.8	-0.6
Hypertension (Self-reported)	0.7	1.9	6.4	0.4	-2.5	0.9	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	2.6	1.4	1.6	1.1	0.7
Illnesses of father: Heart disease	1.3	1.8	5.1	-0.2	0.7	1.2	2.3
Illnesses of siblings: Diabetes	3.6	4.4	7.3	-2.7	-1.7	1.1	2.5
Smoking status: Previous	0.4	0.7	1.3	1.0	1.1	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.3	-1.4	-1.8	-0.1	-0.7
Whole body fat-free mass	0.7	3.9	5.6	-2.4	-2.3	2.1	0.7
Leg fat-free mass (right)	0.2	0.9	1.6	-1.2	-0.9	1.1	-0.0
Arm fat percentage (left)	1.0	4.2	6.0	-1.7	-2.1	2.4	1.9
Average weekly red wine intake	0.4	0.5	0.9	0.9	-0.3	-0.6	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	0.9	0.8	-1.0	-0.5
Mood swings	0.9	1.6	3.0	-1.7	-1.0	0.7	1.4
Loneliness, isolation	1.6	2.3	4.8	-1.8	-2.2	0.9	-0.1
Long-standing illness, disability or infirmity	0.9	1.3	3.4	0.3	1.0	-1.9	-1.0
Ever had bowel cancer screening	0.1	0.1	0.3	-0.0	-0.5	0.3	0.5
Diabetes diagnosed by doctor	2.3	3.8	9.4	-1.4	-0.4	1.9	3.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.7	-0.0	0.5	0.8
Friendships satisfaction	2.6	3.2	6.6	-1.5	-2.6	1.9	0.6
Qualifications: nursing, teaching	0.5	0.8	1.8	1.4	0.7	-0.6	-0.6
Commuting to job workplace: Walk	0.5	0.5	0.8	0.7	0.6	0.6	0.9
Eye problems/disorders: Cataract	0.8	0.9	1.6	-1.1	1.3	0.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	-0.8	0.6	-0.4	-0.5
Medication for cholesterol	0.3	0.4	0.9	0.4	0.3	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	0.0	-1.3	0.4	-0.6
Back pain experienced in last month	0.3	0.5	0.9	0.6	0.1	-1.0	-0.8
Mineral and other dietary supplements	0.7	0.9	2.3	1.5	0.1	-1.0	-0.6
Breast cancer (self-reported)	1.5	1.8	3.2	0.8	1.7	0.8	1.8
Asthma (self-reported)	0.2	0.4	1.2	-0.6	-0.5	1.1	-0.0
Osteoporosis (self-reported)	0.5	0.6	1.5	0.1	1.2	0.8	0.3
Osteoarthritis (self-reported)	1.4	1.8	4.1	-2.0	-0.8	1.3	0.8
Medication: Aspirin	2.2	2.9	6.1	-0.3	1.5	1.7	2.5
Medication: Gliclazide	0.4	0.5	0.9	0.5	-0.9	0.3	-0.8
Illnesses of father: None of the above (group 1)	1.1	1.4	2.7	-1.6	-0.5	-0.4	-1.6
Smoking status: Current	0.9	1.5	2.9	0.9	-0.8	1.2	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.1	-0.6	0.1	-0.2	1.4
Whole body water mass	0.7	4.0	5.3	-2.3	-2.2	2.3	0.8
Leg predicted mass (right)	0.2	0.9	1.5	-1.2	-0.9	1.1	-0.0
Arm fat mass (left)	1.7	6.9	9.7	-2.6	-2.6	3.1	2.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	0.2	-0.4	0.8	0.4
Average weekly champagne plus white wine intake	1.5	2.1	6.5	2.5	1.3	-0.4	0.2
Miserableness	1.0	1.8	2.8	-1.5	-0.9	1.1	1.7
Guilty feelings	0.3	0.4	1.1	-0.6	0.1	-1.0	0.4
Wears glasses or contact lenses	0.5	0.5	1.3	0.8	1.1	0.5	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.3	0.8	1.1	-0.9	-0.1
Hearing aid user	0.4	0.4	1.3	0.6	0.0	-1.1	-0.3
Mother’s age at death	0.2	0.3	0.8	-0.9	-0.1	0.2	0.4
Financial situation satisfaction	0.6	0.7	1.2	-0.7	-0.4	1.0	1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.6	-1.3	-0.8	1.6	0.8
Commuting to job workplace: Public transport	2.1	2.5	4.3	1.9	0.8	-2.1	-1.1
Eye problems/disorders: Glaucoma	0.6	0.8	1.3	0.6	1.1	0.1	1.1
Medication: Blood pressure	0.3	0.6	2.2	-0.2	-1.5	0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	0.2	0.4	-1.6	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.7	-1.0	0.2	1.6	0.6
High cholesterol (Self-reported)	0.8	1.4	3.6	1.9	1.2	-0.7	0.3
Medication: Bendroflumethiazide	0.6	0.8	3.3	-0.1	-1.8	0.2	-0.1
Medication: Paracetamol	0.9	1.4	3.7	-0.3	-0.2	1.9	1.2
Medication: Lisinopril	0.3	0.4	1.1	0.7	-0.3	1.1	0.2
Medication: Atorvastatin	1.4	1.8	3.5	0.9	1.7	0.0	1.9
Illnesses of father: High blood pressure	0.6	0.7	0.9	0.7	-0.9	0.9	0.8
Alcohol drinker status: Never	0.5	0.6	1.6	-1.3	0.5	-0.7	-0.4
Ever smoked	0.8	1.4	3.8	2.0	1.2	-0.3	0.3
Basal metabolic rate	0.9	4.9	7.0	-2.6	-2.4	2.5	1.0
Leg fat percentage (left)	2.6	9.6	13.9	-2.6	-2.8	3.7	3.1
Arm fat-free mass (left)	1.5	7.8	11.6	-3.0	-2.8	3.4	1.7
Number of operations (self-reported)	0.5	0.7	1.0	-0.8	-0.8	0.7	1.0
Average weekly beer plus cider intake	0.5	0.7	2.0	1.4	0.2	-0.8	-0.3
Irritability	0.2	0.4	0.7	-0.8	-0.5	0.8	0.4
Risk taking	0.3	0.4	0.9	0.6	1.0	-0.5	-0.1
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.6	1.3	0.8	-1.8	-1.9
Fractured/broken bones in last 5 years	0.7	0.8	2.0	0.2	0.1	-1.4	-1.1
Age started oral contraceptive pill	1.5	1.9	3.3	-0.6	-1.3	1.8	1.5
Diastolic blood pressure, automated reading	1.1	3.4	7.7	-0.9	-2.8	2.2	0.3
Ever depressed for a whole week	0.4	0.5	1.2	1.1	0.6	-0.6	0.2
Unable to work because of sickness or disability	0.5	0.6	1.0	0.4	-0.9	-1.0	-0.7
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.6	-0.8	0.2	-0.2
Myopia	3.0	4.4	8.6	-1.9	-1.8	2.9	1.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.2	-0.4	2.0	-0.9	0.1
Cholesterol lowering medication	0.9	1.3	1.9	1.4	1.3	-1.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.4	0.2	1.2	0.4	0.2
Pain experienced in last month	0.3	0.5	1.2	1.1	0.5	0.4	0.5
Supplements: Calcium	0.2	0.2	0.5	-0.4	-0.2	0.3	-0.7
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	-1.4	0.5	0.1	0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.1	1.2	1.8	-1.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.8	2.0	1.9	0.1	0.8
Heart disease (siblings)	1.0	1.2	2.2	-0.7	-1.2	0.8	1.5
Alcohol drinker status: Previous	0.5	0.6	1.5	-0.7	-0.2	-1.2	-0.4
Pack years of smoking	0.7	1.0	2.3	1.5	-1.3	0.1	-0.2
Impedance of whole body	0.3	1.5	4.1	-0.8	-2.0	-1.0	-0.7
Leg fat mass (left)	2.5	9.8	13.9	-3.0	-2.9	3.7	2.8
Arm predicted mass (left)	1.7	8.5	11.4	-3.4	-2.8	3.4	1.8