Hub : Genes

LBR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.124	0.0550	3.4e-03	0.042	NA	0.008	NA	0.024	2.4e-03	NA	1.0e-01	NA	1.8e-02
2	GTEx	Artery Tibial	0.493	0.0594	0.0e+00	0.399	NA	0.363	NA	0.398	3.0e-33	NA	1.2e-29	NA	3.4e-33
3	GTEx	Esophagus Muscularis	0.520	0.0770	9.6e-10	0.294	NA	0.297	NA	0.297	3.5e-18	NA	2.0e-18	NA	2.1e-18
4	GTEx	Liver	0.303	0.1130	9.5e-03	-0.010	NA	0.008	NA	0.023	8.7e-01	NA	1.9e-01	NA	7.3e-02
5	GTEx	Nerve Tibial	0.132	0.0466	4.9e-04	0.160	NA	0.119	NA	0.150	2.0e-11	NA	8.8e-09	NA	9.6e-11
6	GTEx	Pancreas	0.319	0.0800	2.8e-07	0.239	NA	0.311	NA	0.293	1.7e-10	NA	1.1e-13	NA	7.6e-13
7	TCGA	Pheochromocytoma and Paraganglioma	0.088	0.0500	6.8e-03	0.004	0.037	0.030	NA	0.007	2.2e-01	0.014	2.4e-02	NA	1.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.5	2.4	3.4	1.8	1.8	1.4	0.0	1.7	-1.4	1.8
Bipolar Disorder or Schizophrenia	0.9	2.1	4.0	1.7	2.0	1.8	-0.0	1.9	0.2	1.0
Depressed Affect (Nagel 2018)	0.3	0.5	2.8	-0.1	-0.1	-0.3	-0.7	-0.2	0.5	-1.7
Depression (Nagel 2018)	0.5	0.8	1.6	-1.0	-0.7	-1.3	0.2	-0.9	1.0	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.1	-0.8	-0.9	-0.8	0.3	-1.0	1.0	-1.0
Neuroticism (Nagel 2018)	1.3	3.1	9.9	0.2	0.1	0.7	-1.4	-0.0	3.1	-3.1
Schizophrenia (2018)	0.4	0.9	1.8	0.8	1.1	1.1	-0.0	1.0	1.4	-0.1
Schizophrenia vs Biploar Disorder	1.7	2.3	7.7	0.5	1.1	1.4	0.6	0.9	2.8	-2.0
Worry (Nagel 2018)	1.9	4.0	9.2	1.2	1.2	2.2	-1.8	1.2	3.0	-2.5
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	0.2	-0.0	-0.6	-1.1	-0.0	-0.0	1.0
Alzheimer’s Disease (in father)	0.8	0.9	3.8	0.1	-0.9	-1.9	-0.4	-0.6	-0.9	0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	3.5	-0.4	-0.8	-1.9	-1.4	-0.6	-0.5	1.0
Crohns Disease (2017)	0.5	1.1	3.4	0.8	0.4	-1.1	1.0	0.4	-1.2	1.9
Irritable Bowel Disease (IBD)	0.2	0.6	2.6	0.2	-0.3	-1.6	-0.9	-0.1	-0.4	0.5
Ulcerative Colitis (UC)	0.5	1.0	3.1	-0.4	-0.7	-1.8	-1.7	-0.5	-0.2	-0.1
Major Depression (MDD)	0.3	0.4	2.2	0.4	0.5	0.2	-0.4	0.4	-1.5	0.1
Reaction Time	0.2	0.4	1.5	-0.5	-0.2	-0.5	1.2	-0.3	0.8	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	-0.7	-0.5	-0.3	0.4	-0.8	1.2	-1.2
Breast Cancer	0.3	0.8	1.8	-0.5	-0.3	-0.0	1.3	-0.5	-1.3	1.1
Ovarian Cancer	0.0	0.0	0.1	-0.1	0.1	0.3	0.3	0.0	0.1	0.0
Prostate Cancer	1.4	2.0	5.4	0.1	0.3	1.6	-1.8	0.3	1.5	-2.3
Age at First Birth	0.9	1.3	4.6	-0.5	-0.8	-2.1	1.3	-0.9	-0.2	0.8
Bipolar Disorder (2011)	0.8	0.8	2.4	0.8	0.2	-0.1	-0.1	0.2	-1.5	1.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.2	-0.1	-0.5	-0.5	1.5	-0.5	-1.1	0.7
Coronary Artery Disease (CAD)	0.4	0.4	1.4	-0.3	-0.4	0.6	-0.9	-0.3	0.4	-1.2
Crohns Disease (2012)	0.3	0.4	1.1	1.0	0.1	-0.7	0.3	0.3	-0.5	1.1
Mean Putamen Volume	0.2	0.2	0.6	-0.0	-0.6	-0.7	-0.4	-0.5	-0.1	0.1
Fasting Glucose	1.1	1.3	4.0	-1.0	-1.4	-2.0	0.5	-1.4	0.3	-0.2
HbA1C	0.9	1.0	1.7	1.3	1.3	0.4	-0.8	1.2	-0.9	0.9
HDL Cholesterol	0.5	0.8	3.4	0.5	-0.2	-0.4	-1.8	-0.0	1.1	-0.7
LDL Cholesterol	0.3	0.5	1.6	0.3	0.8	0.3	1.3	0.7	-0.5	0.2
Lupus	0.6	0.9	2.0	-0.6	-1.4	-1.4	0.1	-1.4	0.1	-0.1
Neuroticism (2016)	1.5	2.2	7.1	-0.5	-0.5	0.2	-2.1	-0.4	1.8	-2.7
Primary Biliary Cirrhosis	4.1	5.8	14.8	2.9	2.0	1.2	0.3	2.1	-2.7	3.9
Rheumatoid Arthritis	0.7	1.0	3.5	0.9	0.5	0.8	0.0	0.5	1.9	-1.2
Schizophrenia (2014)	0.5	1.2	1.8	1.1	1.2	1.3	-0.6	1.3	1.2	-0.4
Triglycerides	0.9	1.5	2.4	0.8	1.2	0.9	1.3	1.2	-1.4	1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	-1.3	-1.2	-1.1	-0.7	-1.0	-0.2	0.7
Ulcerative Colitis	0.5	0.7	4.0	0.4	-0.3	-0.6	-2.0	-0.0	-0.5	0.6
Blood Eosinophil Count	0.2	1.3	5.1	-0.8	-1.2	-2.3	-0.4	-1.2	-0.3	0.0
Blood Platelet Count	0.3	4.0	15.5	0.5	1.0	0.4	-0.9	1.0	-3.9	3.1
Blood Red Count	0.4	3.4	7.0	-2.4	-0.6	0.3	1.9	-1.0	2.6	-2.4
Blood White Count	0.3	2.0	12.9	-0.3	-0.5	-0.1	-3.6	-0.0	-0.7	0.5
Heel T-Score	0.2	1.3	4.5	0.2	-0.1	-0.3	0.2	0.1	-2.1	2.1
BMI	1.4	8.1	18.5	-1.4	-2.1	-3.9	0.2	-1.9	-4.3	3.6
Height	0.1	2.5	9.1	0.9	0.5	0.2	0.4	0.7	-2.6	3.0
Waist Hip Ratio (WHR)	0.4	1.8	4.6	1.1	1.0	0.5	0.2	1.2	-2.1	2.1
Systolic Blood Pressure	0.6	3.1	7.5	-2.7	-2.1	-1.3	1.8	-2.3	-0.0	-0.2
Smoking Status	0.3	0.7	3.1	0.8	-0.0	-0.3	-1.8	0.3	-0.7	0.8
Allergy or Eczema	0.5	1.4	7.6	-0.5	-0.3	-0.0	-2.8	-0.2	0.6	-1.2
Cardiovascular Disease	0.9	2.9	5.5	-2.2	-2.2	-2.4	-0.3	-2.2	0.3	-0.0
Hypothyroidism (self reported)	0.1	0.1	0.4	-0.3	-0.4	-0.3	-0.6	-0.4	0.1	-0.1
Respiratory disease	0.2	0.5	0.9	-0.8	-0.3	-1.0	0.1	-0.4	0.9	-0.8
Type 2 Diabetes (T2D) (2018)	1.8	3.4	6.4	-2.3	-2.4	-2.5	-0.6	-2.4	-0.6	0.6
Lung FEV1/FVC ratio	0.9	4.5	19.8	1.8	1.1	0.1	0.2	1.4	-2.3	4.5
Lung FVC	0.4	2.3	6.3	-1.6	-1.2	-0.9	0.6	-1.5	1.4	-2.5
Neuroticism	1.0	2.4	8.3	0.3	0.3	1.0	-1.6	0.2	2.2	-2.9
Chronotype (morning person)	0.2	0.4	1.1	1.1	0.8	0.2	-0.1	0.8	0.4	0.5
Hair Pigment	0.1	1.7	4.1	-0.9	-1.2	-0.5	-0.7	-1.3	2.0	-1.8
Tanning	0.1	0.7	2.4	-0.5	-0.2	0.3	-0.2	-0.2	1.6	-1.4
Hand grip strength (left)	0.7	1.8	6.6	0.5	0.3	-1.3	-0.7	0.4	-2.6	1.8
Number of treatments/medications taken	0.4	0.7	3.0	-1.7	-0.8	-0.3	-0.6	-0.8	-0.2	-0.2
Average weekly spirits intake	2.6	3.2	8.4	-1.6	-2.1	-2.9	-0.6	-1.9	-1.6	-0.5
Sensitivity / hurt feelings	3.5	5.9	16.5	-1.4	-1.8	-1.4	-1.3	-1.8	4.1	-3.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.7	-1.6	-1.1	-1.9	0.1	-1.2	-0.1	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	1.7	-0.1	0.1	-0.7	0.9	-0.1	-1.3	0.5
Relative age of first facial hair	0.6	1.3	1.8	-0.8	-1.1	-1.1	1.0	-1.3	-1.2	1.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.6	-1.3	-0.9	-0.2	-2.1	-0.8	0.4	-2.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	0.4	0.3	0.5	-1.0	0.4	0.2	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.5	-0.7	-0.1	0.2	-0.2	-0.2	0.0	-0.6
Systolic blood pressure, automated reading	1.0	2.8	5.9	-2.4	-1.7	-1.3	2.3	-1.9	-0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.6	-1.2	-0.9	-0.9	1.6	-1.1	1.5	-1.2
Angina	0.7	0.9	2.5	-0.7	-1.1	-1.6	-0.8	-0.9	0.5	-0.5
Medication for hormone replacement therapy	0.0	0.0	0.2	-0.2	0.0	-0.1	-0.4	0.1	0.1	0.2
Vitamin and mineral supplements	0.4	0.5	1.8	1.0	0.4	0.4	-1.4	0.6	0.2	-0.4
Supplements: Zinc	3.6	3.9	7.6	2.3	2.2	1.1	0.1	2.2	-1.9	2.8
Medication: Co-codamol	0.8	0.9	2.8	1.0	0.2	-0.3	-0.2	0.4	-1.7	1.5
Medication: Metformin	0.7	1.0	3.1	-1.1	-0.8	-1.1	1.7	-1.0	0.4	0.1
Diabetes (father)	0.5	0.6	1.3	-1.1	-1.0	-0.9	-0.1	-1.0	-0.0	0.0
Diabetes (mother)	0.3	0.4	0.7	-0.8	-0.7	-0.8	0.3	-0.6	0.6	-0.6
Severe depression (siblings)	0.3	0.3	1.0	0.6	0.5	1.0	-0.4	0.5	0.4	-0.2
Pack years adult smoking proportion	0.5	0.8	1.3	-0.9	-1.2	-0.9	-0.9	-1.0	-0.7	0.8
Impedance of leg (right)	3.2	15.4	26.5	5.2	5.1	5.0	-0.1	5.1	-0.4	1.9
Leg fat-free mass (left)	1.3	7.1	14.6	-1.9	-2.3	-3.7	-0.1	-2.2	-3.8	2.8
Trunk fat percentage	2.4	9.8	26.3	2.4	2.3	0.1	1.8	2.4	-4.7	5.1
Hand grip strength (right)	0.8	2.2	8.4	0.3	0.4	-1.1	-0.7	0.4	-2.9	2.2
Townsend deprivation index at recruitment	2.1	2.9	5.6	-2.4	-2.1	-1.2	-0.5	-2.1	0.9	-1.9
Current tobacco smoking	0.8	1.3	2.9	-0.8	-1.3	-1.6	-1.7	-0.9	0.4	-0.1
Average weekly fortified wine intake	1.9	2.2	4.2	0.9	1.6	1.0	1.4	1.5	-1.7	2.0
Maternal smoking around birth	0.1	0.1	0.4	0.1	-0.3	-0.4	-0.7	-0.1	-0.4	0.3
Fed-up feelings	0.5	0.9	1.6	-0.9	-1.0	-0.6	-1.2	-1.0	-0.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	4.7	-2.0	-1.9	-1.5	-1.1	-1.8	1.4	-2.2
Relative age voice broke	1.0	1.6	3.9	1.2	0.8	0.6	1.5	0.6	-1.4	2.0
Taking other prescription medications	0.3	0.4	2.2	-0.3	0.1	0.5	-1.5	0.3	0.3	-0.1
Age when periods started (menarche)	2.3	5.5	14.5	2.3	2.4	2.0	-0.2	2.5	-1.4	3.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.5	-1.4	-1.5	-1.9	-0.1	-1.5	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.6	0.8	0.1	0.9	-0.7	0.4	-1.2	1.3
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.6	0.7	1.0	1.6	1.0	1.0	0.6	0.5
Qualifications: CSEs or equivalent	2.1	2.7	5.7	-1.4	-1.9	-2.4	-0.6	-1.8	-1.9	0.9
Serious illness, injury or assault to yourself	0.9	1.0	2.6	-1.6	-1.0	0.5	-0.4	-1.1	0.3	-1.4
High blood pressure	2.0	5.5	9.7	-3.1	-2.9	-2.0	-0.7	-2.9	2.0	-2.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	5.1	-0.5	-0.5	0.4	-2.3	-0.4	0.5	-1.1
Multivitamins +/- minerals	0.5	0.7	1.7	-1.3	-0.8	-1.0	0.6	-0.9	0.4	-0.1
Stomach or abdominal pain in last month	0.7	0.9	2.5	-0.1	0.9	1.6	-0.6	0.9	1.4	-0.3
Supplements: Glucosamine	1.2	1.6	7.0	-0.1	-0.4	-0.6	2.6	-0.5	-0.9	1.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	-0.6	-0.3	-0.5	1.1	-0.3	-0.5	0.2
Medication: Atenolol	0.6	0.8	1.3	-1.0	-1.1	-0.7	0.4	-1.1	-0.9	0.6
Medication: Levothyroxine sodium	0.1	0.2	0.7	-0.3	-0.2	-0.2	0.0	-0.1	0.8	-0.6
Sitting height	0.1	0.6	1.7	-0.5	-0.4	-0.3	0.9	-0.5	-1.3	0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	0.3	0.5	1.3	-0.2	0.6	0.9	-1.0
High blood pressure (mother)	0.9	1.3	2.6	-1.3	-1.2	-0.4	-0.5	-1.3	1.1	-1.6
Body mass index (BMI)	1.6	6.9	15.0	-1.7	-1.9	-3.6	1.3	-1.8	-3.9	2.9
Impedance of leg (left)	2.9	14.1	25.0	4.8	5.0	4.8	0.4	4.9	-0.1	1.6
Leg predicted mass (left)	1.3	7.0	14.4	-1.8	-2.3	-3.7	-0.1	-2.2	-3.8	2.7
Trunk fat mass	2.0	8.7	26.9	1.4	1.1	-0.9	1.4	1.3	-5.1	5.2
Waist circumference	1.5	5.5	17.2	-0.5	-0.8	-2.5	0.9	-0.7	-4.2	3.6
Number of incorrect matches in round	0.3	0.5	1.4	-0.1	0.4	0.8	0.4	0.3	1.1	-1.2
Past tobacco smoking	0.3	0.6	1.3	-1.1	-0.8	-0.7	0.6	-0.9	0.7	-0.5
Alcohol usually taken with meals	2.2	3.5	5.5	1.9	2.0	2.3	-1.3	1.9	2.4	-1.2
Nervous feelings	2.3	4.3	11.6	0.9	0.6	2.1	-2.0	0.6	3.4	-2.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	-1.4	-1.2	-0.9	-0.4	-1.3	0.2	-0.4
Hearing difficulty/problems with background noise	0.3	0.4	1.5	-0.8	0.0	0.0	1.2	-0.3	0.4	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	0.4	0.1	-0.3	-1.2	0.2	-0.7	0.8
Had menopause	0.8	1.0	4.9	-0.7	0.0	0.6	0.1	-0.1	2.2	-1.3
Had other major operations	0.7	0.8	1.7	-1.0	-0.7	-0.2	-0.3	-0.9	1.3	-1.3
Forced vital capacity (FVC)	0.1	0.5	2.3	0.3	0.2	-0.3	-0.9	0.2	-1.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.7	0.2	-0.6	-0.2	-0.9	-0.2	-1.3	1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.5	-1.5	-1.1	0.2	0.9	-1.4	0.9	-1.6
Qualifications: None of the above	0.4	0.8	1.5	0.9	0.8	1.2	0.3	1.0	1.2	-0.2
Financial difficulties in last 2 years	0.7	0.9	1.6	-1.3	-1.2	-1.2	-0.8	-1.0	0.2	-0.5
Mouth/teeth dental problems	0.6	0.9	3.8	0.0	0.0	-1.1	0.2	0.1	-2.0	1.1
Heart attack	2.1	2.7	4.5	-2.0	-2.1	-2.0	-0.7	-2.1	-1.1	-0.1
Allergy	1.2	2.8	6.8	1.6	1.2	0.7	2.6	1.2	-1.3	2.4
Pain all over the body in last month	0.6	0.6	2.2	0.5	0.2	0.0	-1.5	0.3	-0.9	0.8
Diabetes (self-reported)	0.7	1.0	2.1	-1.1	-1.2	-1.5	-0.3	-1.2	0.8	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.4	-0.8	-0.4	-0.1	-0.8	0.3	0.2
Medication: Ramipril	2.5	3.3	6.1	-2.3	-2.3	-2.5	-0.4	-2.3	0.6	-0.3
Medication: Simvastatin	0.2	0.2	0.6	-0.8	-0.5	-0.5	0.1	-0.5	0.5	-0.2
Fluid intelligence score	1.2	2.5	5.3	-1.5	-1.7	-1.1	-0.4	-1.8	1.6	-2.3
Illnesses of siblings	0.2	0.3	0.8	0.6	0.3	0.7	0.3	0.3	-0.9	0.2
Neuroticism score	1.1	2.3	7.5	-1.2	-1.3	-1.1	-1.1	-1.4	1.1	-2.7
Weight	1.6	8.0	23.9	-0.9	-1.3	-3.2	1.1	-1.2	-4.9	4.1
Impedance of arm (right)	3.2	14.9	30.7	4.8	4.9	5.5	-0.7	4.9	1.2	0.4
Arm fat percentage (right)	0.9	3.6	11.0	-0.1	-0.2	-1.5	1.1	-0.1	-3.3	3.2
Trunk fat-free mass	1.5	8.7	17.0	-2.8	-3.4	-4.1	-0.1	-3.3	-3.2	2.0
Hip circumference	1.2	5.4	15.7	-0.8	-1.1	-2.9	1.1	-1.1	-4.0	3.0
Time employed in main current job	0.6	0.7	1.4	1.2	0.7	0.7	0.8	0.6	-0.8	1.1
Alcohol intake versus 10 years previously	0.0	0.1	0.3	-0.0	-0.1	-0.6	0.1	-0.1	-0.1	0.3
Father’s age at death	0.8	1.1	2.4	0.2	0.7	1.0	1.1	0.4	1.5	-1.6
Worrier / anxious feelings	0.9	1.7	7.2	0.3	0.6	1.1	-0.7	0.5	2.7	-1.5
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.3	17.1	-2.5	-1.8	-0.8	-0.9	-1.9	2.4	-4.1
Falls in the last year	1.3	1.7	3.7	0.8	1.0	1.4	0.8	1.0	-1.9	1.7
Hair/balding pattern: Pattern 3	0.4	0.6	3.3	0.4	0.4	0.5	1.8	0.1	0.2	-0.6
Number of live births	1.2	1.7	8.7	-0.4	0.2	0.7	0.2	0.1	2.9	-1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.8	1.0	0.6	0.2	-0.7	0.6	-1.3	0.9
Pulse rate	0.5	0.9	1.8	1.0	1.3	0.9	0.0	1.3	0.2	1.0
Happiness	0.6	0.8	2.5	-1.0	-0.8	-1.6	-0.7	-0.7	-0.4	-0.2
Noisy workplace	0.1	0.1	0.3	-0.1	-0.2	0.2	0.1	-0.1	0.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.1	0.0	0.4	1.5	0.3	0.1	1.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	-1.2	-0.3	0.2	-0.3	-0.5	0.2	-0.5
Mouth/teeth dental problems: Dentures	0.7	1.1	2.0	1.4	1.2	1.2	1.0	1.1	0.8	0.4
Asthma	0.4	0.9	2.3	-1.0	-0.8	-1.5	-0.0	-0.8	0.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.6	7.9	1.8	1.8	0.7	0.2	1.8	-2.8	2.7
Medication: Cholesterol lowering	0.1	0.1	0.6	-0.3	0.2	0.1	0.1	0.1	-0.8	0.3
Depression (self-reported)	1.4	1.7	2.7	1.0	1.6	1.5	0.2	1.5	-1.6	1.2
Medication: Lansoprazole	0.9	1.0	4.1	-1.0	-1.0	-0.2	-2.0	-0.7	-0.1	-0.4
Prospective memory result	1.4	1.7	3.3	1.3	1.1	1.3	-1.1	1.4	-0.9	1.8
Lung cancer (father)	0.5	0.6	2.1	1.4	0.3	0.5	-1.1	0.5	-0.0	-0.1
Illnesses of mother	0.6	0.8	2.1	0.7	0.8	0.4	0.6	0.8	-1.4	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.5	0.7	0.1	0.1	-0.7	0.1	-1.2	0.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.6	0.3	0.3	0.1	0.8	0.1	-0.0	0.5
Impedance of arm (left)	3.7	16.9	31.9	5.2	5.3	5.7	-0.4	5.4	0.0	1.6
Arm fat mass (right)	1.6	6.6	18.3	-0.9	-1.2	-2.9	1.3	-1.1	-4.3	3.8
Trunk predicted mass	1.6	8.9	17.5	-2.8	-3.4	-4.2	-0.2	-3.3	-3.2	2.1
Standing height	0.4	4.1	11.3	1.9	1.4	0.7	-0.2	1.5	-3.0	3.4
Length of working week for main job	0.2	0.3	0.9	0.1	0.2	0.3	0.5	0.1	-1.0	0.7
Exposure to tobacco smoke at home	0.9	1.1	2.0	1.3	1.0	1.4	-1.0	1.2	-0.3	0.6
Breastfed as a baby	0.6	0.7	2.1	0.0	-0.3	-1.0	0.1	-0.3	-1.4	1.4
Tense / ‘highly strung’	0.4	0.6	2.6	-0.1	-0.6	-0.6	-1.6	-0.5	-0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	-0.5	-0.9	-0.8	-0.6	-0.9	0.3	-0.5
Hair/balding pattern: Pattern 4	0.2	0.6	1.2	1.1	0.8	1.0	-0.5	0.9	-0.4	-0.4
Birth weight of first child	0.3	0.6	2.3	-0.3	-0.1	0.3	0.4	-0.2	1.3	-1.5
Peak expiratory flow (PEF)	0.5	1.2	2.8	1.5	0.9	0.4	-1.7	0.9	-0.9	0.8
Pulse wave reflection index	0.1	0.1	0.7	0.1	-0.2	-0.2	-0.1	-0.1	-0.8	0.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.2	1.8	1.6	1.6	0.7	1.5	-0.3	0.8
Loud music exposure frequency	0.5	0.5	2.6	0.2	-0.7	-0.2	-1.6	-0.5	0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.5	-0.4	0.1	0.2	0.3	-0.2	-0.7	0.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.9	-1.7	-1.5	-0.9	-1.0	-1.6	0.6	-1.0
Blood clot in the leg (DVT)	1.5	2.0	8.6	-0.6	-1.1	-0.8	-2.9	-0.9	1.0	-1.1
Medication: Paracetamol	1.5	2.6	9.7	-1.0	-0.4	-0.7	-1.0	-0.3	-3.1	2.3
Headache pain in last month	0.3	0.5	0.9	-0.9	-0.8	-0.2	-0.8	-0.7	-1.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	0.9	0.2	0.5	0.2	0.3	-0.0	-0.0
Glaucoma (self-reported)	0.1	0.1	0.4	0.7	0.3	0.1	-0.1	0.3	-0.2	0.3
Gout (self-reported)	0.4	0.5	2.6	-0.2	-0.5	0.4	1.6	-0.6	-0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.4	-0.4	-0.6	-0.7	-0.4	0.7	-0.7
Medication: Amlodipine	0.3	0.5	0.7	-0.9	-0.7	-0.7	0.5	-0.8	0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.7	-0.4	-0.1	0.0	0.0	-0.2	1.9	-0.9
Birth weight	0.4	0.9	2.9	-0.8	-0.9	-0.6	1.7	-1.2	0.5	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	0.7	1.0	1.0	-0.3	1.0	-0.5	0.5
High blood pressure (siblings)	0.6	0.8	1.6	-1.2	-1.0	-0.8	0.3	-1.1	1.0	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	1.1	0.4	-0.0	0.1	-0.7	-0.0	-1.1	0.3
Body fat percentage	1.8	7.2	21.1	1.6	1.5	-0.6	1.7	1.6	-4.3	4.6
Leg fat percentage (right)	1.6	5.9	18.2	0.9	0.7	-1.1	1.5	0.9	-4.3	4.2
Arm fat-free mass (right)	1.9	9.6	19.8	-2.5	-2.8	-4.5	0.8	-2.7	-4.1	2.9
Exposure to tobacco smoke outside home	1.1	1.4	5.0	1.3	0.7	-0.6	-0.4	0.9	-1.3	2.2
Comparative body size at age 10	0.6	1.5	3.3	-0.5	-1.5	-1.8	-1.8	-1.2	-0.1	-0.3
Number of full brothers	1.1	1.4	4.3	-1.1	-1.2	-0.6	0.3	-1.2	2.1	-1.0
Worry too long after embarrassment	3.6	6.1	14.8	-2.1	-2.3	-1.5	-0.3	-2.5	3.1	-3.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.2	0.0	-0.3	0.6	0.1	0.0	0.8
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.7	-0.4	-0.3	-0.2	-0.3	1.1	-0.5
Number of children fathered	1.5	1.6	3.2	1.0	0.6	0.1	-1.7	0.8	-1.8	1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.9	8.1	1.7	1.5	0.6	0.8	1.4	-2.0	2.8
Age at first live birth	0.9	1.7	3.5	1.8	1.9	0.7	1.4	1.6	0.1	0.3
Pulse wave peak to peak time	0.1	0.1	0.4	-0.4	-0.4	-0.3	-0.6	-0.3	-0.0	-0.3
Health satisfaction	0.2	0.2	0.6	0.8	0.0	-0.5	-0.6	0.3	-0.5	0.3
Shortness of breath walking on level ground	1.0	1.2	4.6	-0.2	-0.0	0.8	-2.1	0.1	0.9	-1.6
Qualifications: College or University degree	0.2	0.5	1.7	0.3	0.5	0.8	1.0	0.1	1.3	-0.5
Eye problems/disorders: None of the above	1.8	2.0	4.2	1.4	2.0	1.5	-0.1	1.9	1.5	-0.3
Mouth/teeth dental problems: Loose teeth	2.2	2.6	7.5	-1.4	-1.8	-2.7	-1.4	-1.7	-0.9	-0.2
Emphysema/chronic bronchitis	0.8	0.9	2.9	-0.5	0.2	0.7	0.4	0.1	1.7	-1.5
Medication for pain relief, constipation, heartburn	2.6	4.4	12.1	-0.7	-1.1	-0.6	2.0	-1.3	3.5	-3.4
Neck or shoulder pain in last month	1.1	1.5	5.0	0.9	0.9	1.6	-2.2	1.0	-0.7	0.0
Medication: Blood pressure	1.2	2.2	3.1	-1.6	-1.6	-1.8	-1.5	-1.6	1.0	-1.0
Angina (self-reported)	0.7	0.9	2.6	-0.7	-1.2	-1.6	-0.9	-0.9	0.4	-0.3
Migraine (self-reported)	0.3	0.4	1.2	-0.7	-0.3	-0.7	-0.5	-0.1	-1.1	0.4
Medication: Ibuprofen	2.0	2.4	6.5	1.1	1.2	0.5	-0.1	1.3	-2.5	2.3
Medication: Allopurinol	0.3	0.5	1.4	0.1	-0.2	0.5	1.2	-0.4	-0.9	0.8
Medication: Omeprazole	0.7	0.8	1.6	0.8	0.7	1.3	-0.9	0.9	-0.3	1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.5	-0.3	-0.8	-0.2	-0.3	-0.2	0.4
Mean time to correctly identify matches	0.7	1.3	3.3	-0.8	-0.3	-0.4	1.8	-0.5	1.8	-1.3
Heart disease (mother)	1.3	1.6	2.8	-1.3	-1.5	-1.7	0.5	-1.5	0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	7.0	-2.1	-1.5	0.3	-0.7	-1.6	2.1	-2.6
Whole body fat mass	1.9	7.9	25.4	0.7	0.3	-1.7	1.5	0.5	-5.0	4.9
Leg fat mass (right)	1.5	6.0	19.6	-0.0	-0.4	-2.1	1.0	-0.2	-4.4	4.1
Arm predicted mass (right)	1.8	9.0	18.7	-2.1	-2.4	-4.2	0.7	-2.4	-4.3	3.3
Pulse rate, automated reading	0.2	0.7	1.5	0.3	0.9	1.1	-0.3	0.9	1.2	0.0
Alcohol intake frequency.	1.4	3.3	5.6	-2.0	-2.4	-1.8	-0.7	-2.3	1.5	-1.3
Comparative height size at age 10	0.2	1.2	2.3	1.5	1.2	0.6	-0.6	1.2	-1.0	1.3
Number of full sisters	0.9	1.0	2.4	0.8	1.0	0.5	1.5	0.9	-1.0	1.1
Suffer from ‘nerves’	1.3	2.0	5.6	-1.4	-0.9	0.0	-0.4	-1.1	2.1	-2.4
Overall health rating	0.6	1.2	2.7	-1.2	-1.0	-0.4	-1.7	-0.9	0.6	-1.4
Chest pain or discomfort	0.4	0.6	1.3	-0.6	-1.0	0.0	-0.7	-0.9	0.4	-1.1
Had major operations	0.3	0.3	0.7	0.4	0.8	0.6	0.3	0.8	-0.1	0.7
Age at last live birth	1.6	2.4	4.3	1.7	2.1	1.3	2.1	1.7	-0.1	0.6
Family relationship satisfaction	0.2	0.3	1.1	-0.2	0.1	0.9	-0.1	-0.0	0.4	-1.1
Leg pain on walking	0.4	0.4	1.1	-0.3	-0.3	0.2	-1.0	-0.2	1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.9	0.2	0.5	1.7	-0.5	0.5	-0.6	0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	5.1	0.6	-0.2	-1.1	-2.3	0.1	-1.1	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.6	1.5	1.6	0.8	1.6	1.4	0.5	0.2
Medication: Aspirin	0.4	0.5	2.2	0.6	0.4	-0.5	-0.3	0.4	-0.8	1.5
Supplements: Vitamin C	2.5	2.9	9.9	0.0	-0.0	-0.8	1.1	0.0	-3.0	3.1
Knee pain experienced in last month	0.3	0.5	1.3	0.4	0.6	1.0	0.4	0.6	-1.1	0.3
Hypertension (Self-reported)	1.8	4.9	9.0	-3.0	-2.7	-2.1	-0.1	-2.7	1.7	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.4	-0.2	0.1	1.2	-0.6	0.3	-0.1	0.5
Illnesses of father: Heart disease	0.3	0.5	1.0	0.4	1.0	0.2	0.3	0.9	-1.0	0.4
Illnesses of siblings: Diabetes	1.2	1.5	2.2	-1.3	-1.1	-1.5	0.1	-1.2	1.5	-1.2
Smoking status: Previous	0.5	0.7	1.5	1.2	1.0	0.8	-0.6	1.1	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	7.8	-1.1	-2.1	-2.8	-0.5	-2.0	-2.8	1.8
Whole body fat-free mass	1.5	8.6	17.4	-2.5	-3.0	-4.2	-0.0	-2.9	-3.6	2.4
Leg fat-free mass (right)	1.3	7.2	15.0	-2.2	-2.6	-3.9	-0.0	-2.5	-3.5	2.3
Arm fat percentage (left)	1.2	4.9	15.7	0.1	0.1	-1.5	1.3	0.2	-4.0	3.8
Average weekly red wine intake	1.2	1.8	3.4	1.6	1.8	1.8	-0.4	1.7	0.5	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.5	0.1	-0.0	-0.5	-1.6	0.0	0.5	-0.4
Mood swings	0.9	1.6	3.2	-1.1	-1.3	-1.2	-1.8	-1.2	-0.3	-1.5
Loneliness, isolation	1.8	2.5	5.7	-1.6	-1.9	-2.4	-0.8	-1.8	-1.4	-0.5
Long-standing illness, disability or infirmity	1.0	1.5	4.5	-1.2	-1.0	-0.0	-1.0	-1.0	1.2	-2.1
Ever had bowel cancer screening	1.4	1.6	4.8	-0.3	0.1	2.2	0.1	0.1	2.0	-1.4
Diabetes diagnosed by doctor	1.8	3.0	5.6	-2.3	-2.1	-2.4	0.5	-2.2	0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.8	0.5	0.3	-0.1	1.3	0.3	-1.7	0.6
Friendships satisfaction	0.6	0.8	1.9	1.4	1.0	0.6	-0.4	1.2	0.8	-0.3
Qualifications: nursing, teaching	1.1	1.6	8.3	-0.0	-0.3	-0.6	-2.9	-0.1	-1.7	-0.0
Commuting to job workplace: Walk	0.4	0.5	1.1	-1.0	-0.5	-0.4	0.7	-0.6	0.4	-1.0
Eye problems/disorders: Cataract	0.6	0.7	1.5	-0.4	-1.2	-0.8	-0.7	-1.1	-0.8	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.8	-1.0	-0.2	2.2	-0.3	-0.4	1.6	-1.7
Medication for cholesterol	0.4	0.7	1.4	1.2	0.9	1.0	-0.4	0.9	-0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	5.1	1.9	2.3	1.8	-0.3	2.2	-0.4	1.2
Back pain experienced in last month	0.7	1.0	3.2	-0.1	0.7	1.2	0.7	0.6	-1.8	0.9
Mineral and other dietary supplements	1.2	1.7	3.9	-0.8	-1.0	-0.6	-1.8	-0.9	1.4	-2.0
Breast cancer (self-reported)	0.3	0.4	0.9	-0.3	0.3	0.6	-0.7	0.2	0.9	-0.8
Asthma (self-reported)	0.5	1.0	2.7	-1.2	-0.9	-1.7	0.2	-1.0	0.6	-0.8
Osteoporosis (self-reported)	0.6	0.7	2.9	-0.7	0.3	0.6	0.6	0.1	1.7	-0.9
Osteoarthritis (self-reported)	0.3	0.4	1.4	-1.2	-0.7	0.2	-0.0	-0.8	0.2	-0.5
Medication: Aspirin	0.5	0.6	2.7	0.8	0.5	-0.4	0.2	0.5	-0.6	1.7
Medication: Gliclazide	0.2	0.2	1.2	0.1	-0.4	-0.0	1.1	-0.4	0.1	0.1
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	1.2	1.1	0.9	0.5	1.2	-0.9	1.4
Smoking status: Current	0.6	0.9	2.6	-0.6	-1.1	-1.6	-1.2	-0.8	0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.9	2.0	1.5	1.8	-1.4	1.6	-0.7	0.2
Whole body water mass	1.5	8.6	17.9	-2.5	-3.1	-4.2	0.0	-3.0	-3.5	2.3
Leg predicted mass (right)	1.3	7.1	14.9	-2.2	-2.6	-3.9	-0.1	-2.5	-3.4	2.2
Arm fat mass (left)	1.7	7.1	21.1	-0.7	-0.9	-2.7	1.5	-0.8	-4.6	4.1
Number of self-reported non-cancer illnesses	0.9	1.6	3.5	-1.9	-1.6	-1.1	-1.0	-1.6	0.1	-0.8
Average weekly champagne plus white wine intake	0.3	0.4	1.7	0.5	0.8	0.2	1.3	0.6	0.4	-0.0
Miserableness	0.1	0.2	0.7	-0.0	-0.3	-0.8	-0.8	-0.2	-0.4	-0.3
Guilty feelings	0.7	1.1	2.4	-1.0	-1.0	-1.6	0.5	-1.1	0.3	-1.2
Wears glasses or contact lenses	0.8	1.0	2.3	-1.1	-0.7	0.6	-0.8	-0.8	1.1	-1.5
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.5	0.3	-0.3	-0.8	0.4	-0.1	0.1
Hearing aid user	0.1	0.1	0.3	-0.3	-0.4	-0.5	0.4	-0.5	0.0	0.2
Mother’s age at death	0.8	1.0	1.9	-0.8	-0.9	-0.5	0.5	-1.0	1.4	-1.3
Financial situation satisfaction	0.3	0.4	0.8	-0.5	-0.9	-0.8	-0.5	-0.9	-0.2	0.2
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.2	-1.8	-1.6	-1.7	0.3	-1.8	0.4	-0.6
Commuting to job workplace: Public transport	0.8	1.0	5.1	-0.8	-0.6	-0.3	2.3	-0.7	-0.2	0.5
Eye problems/disorders: Glaucoma	0.6	0.8	1.3	-0.5	-1.1	-0.9	-1.1	-1.0	0.7	-0.7
Medication: Blood pressure	0.8	1.5	3.7	-1.9	-1.3	-1.3	0.9	-1.4	0.7	-0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.5	-0.5	-0.7	0.1	-1.6	-0.6	-0.6	-0.4
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.6	1.4	1.6	1.2	1.0	1.6	-1.2	1.9
High cholesterol (Self-reported)	0.2	0.3	0.8	-0.9	-0.7	-0.5	-0.5	-0.5	-0.4	-0.1
Medication: Bendroflumethiazide	0.3	0.5	2.1	-0.8	-0.2	-0.2	-0.3	-0.2	0.8	-1.5
Medication: Paracetamol	1.5	2.4	9.9	-0.5	0.1	-0.3	-1.0	0.2	-3.1	2.3
Medication: Lisinopril	0.3	0.4	1.1	0.4	0.0	0.6	-1.0	0.1	0.9	-0.9
Medication: Atorvastatin	0.3	0.4	0.9	-0.8	-0.6	-0.9	-0.6	-0.6	-0.4	0.2
Illnesses of father: High blood pressure	1.4	1.7	3.8	-1.0	-1.0	-0.4	-1.3	-1.0	1.8	-2.0
Alcohol drinker status: Never	0.9	1.1	2.2	-1.5	-1.1	-1.1	0.7	-1.2	0.3	-1.1
Ever smoked	0.6	1.1	4.6	1.1	0.7	0.8	-2.1	0.9	-0.4	0.4
Basal metabolic rate	1.6	8.7	17.0	-2.1	-2.7	-4.1	0.2	-2.5	-4.1	3.0
Leg fat percentage (left)	1.6	5.8	17.5	0.6	0.6	-1.3	1.9	0.6	-4.2	4.1
Arm fat-free mass (left)	1.6	8.1	17.0	-2.1	-2.6	-4.1	0.7	-2.5	-3.7	2.8
Number of operations (self-reported)	1.4	2.0	4.9	-2.2	-1.8	-1.2	0.5	-2.0	-0.5	0.3
Average weekly beer plus cider intake	2.9	4.2	20.2	-0.2	-0.7	-1.2	-0.8	-0.5	-4.5	2.4
Irritability	0.4	0.7	2.5	0.3	-0.0	-0.2	-1.3	-0.0	-1.6	-0.7
Risk taking	0.8	1.2	3.2	-0.5	-0.6	-1.3	1.1	-0.7	-1.8	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.8	0.1	0.1	-0.2	0.4	0.1	-1.7	1.4
Fractured/broken bones in last 5 years	0.5	0.7	0.9	-0.9	-0.9	-0.8	0.8	-0.9	-0.4	0.8
Age started oral contraceptive pill	0.6	0.7	2.8	-0.9	-0.5	-0.6	1.7	-0.7	0.3	-0.2
Diastolic blood pressure, automated reading	0.6	1.9	3.0	-1.4	-1.0	-1.5	1.6	-1.1	-1.7	1.2
Ever depressed for a whole week	0.2	0.2	0.9	-0.4	-0.2	0.1	1.0	-0.5	-0.2	-0.6
Unable to work because of sickness or disability	0.9	1.2	2.7	-1.3	-1.6	-1.4	-0.1	-1.5	0.2	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.2	-0.8	-0.6	-0.8	-0.2	-0.8	1.1	-0.7
Myopia	0.1	0.2	0.6	0.4	0.4	0.3	0.8	0.2	-0.1	0.3
Vascular/heart problems diagnosed by doctor	1.7	4.7	8.8	3.0	2.8	2.1	0.6	2.8	-1.4	1.6
Cholesterol lowering medication	0.2	0.3	0.6	-0.6	-0.7	-0.8	0.6	-0.6	0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.5	1.1	1.1	1.5	-0.6	1.1	-0.7	1.6
Pain experienced in last month	1.4	2.4	7.4	-0.8	-0.9	-1.8	-0.1	-1.0	2.7	-1.9
Supplements: Calcium	0.8	0.9	2.4	0.0	0.3	0.2	1.6	0.2	-1.2	1.5
Basal cell carcinoma (self-reported)	1.3	1.5	3.2	-0.8	-0.8	0.7	1.3	-1.0	1.7	-1.8
Heart attack/myocardial infarction (self-reported)	2.6	3.4	5.8	-2.3	-2.4	-2.2	-0.9	-2.4	-1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	7.0	-0.5	-1.0	-0.6	-2.7	-0.8	0.6	-0.7
Heart disease (siblings)	0.3	0.4	0.9	0.9	0.4	0.2	-0.6	0.5	-0.5	0.8
Alcohol drinker status: Previous	0.9	1.1	4.9	-0.1	-0.1	0.6	-1.1	-0.1	2.2	-1.0
Pack years of smoking	0.2	0.3	0.6	-0.6	-0.8	-0.5	-0.3	-0.6	-0.4	0.7
Impedance of whole body	3.5	17.6	31.9	5.3	5.6	5.7	0.2	5.5	0.4	1.3
Leg fat mass (left)	1.6	6.2	19.6	-0.2	-0.5	-2.2	1.3	-0.4	-4.4	4.1
Arm predicted mass (left)	1.8	9.3	21.0	-2.6	-3.1	-4.6	0.4	-3.0	-3.5	2.4