Hub : Genes

LDHAL6A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2460	0.0420	1.2e-15	0.176	0.165	0.194	0.186	0.190	6.0e-21	1.5e-19	3.8e-23	3.6e-22	1.5e-22
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0324	0.0168	3.1e-03	-0.002	0.014	0.003	NA	0.000	8.3e-01	9.3e-03	1.2e-01	NA	2.9e-01
3	TCGA	Brain Lower Grade Glioma	0.0414	0.0198	1.3e-03	0.001	0.015	0.005	NA	0.001	2.2e-01	7.2e-03	7.8e-02	NA	2.5e-01
4	TCGA	Prostate Adenocarcinoma	0.0362	0.0197	5.4e-03	0.002	0.019	0.002	NA	0.001	1.9e-01	4.2e-03	2.1e-01	NA	2.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.4	1.2	0.1	-1.1	0.0
Bipolar Disorder or Schizophrenia	0.2	0.6	1.7	0.5	-0.5	-1.3	-0.2
Depressed Affect (Nagel 2018)	1.6	3.3	5.0	1.6	2.2	0.9	2.2
Depression (Nagel 2018)	0.1	0.1	0.3	0.3	-0.5	-0.3	-0.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	-1.3	-0.9	-0.9	-1.0
Neuroticism (Nagel 2018)	1.3	3.2	4.9	1.4	2.2	0.9	2.2
Schizophrenia (2018)	0.3	0.5	1.0	-0.5	-0.8	-1.0	-0.5
Schizophrenia vs Biploar Disorder	1.9	2.5	5.3	-2.3	-0.8	-1.7	-1.2
Worry (Nagel 2018)	0.8	1.6	2.5	1.1	1.4	0.7	1.6
Alzheimer’s Disease (in mother)	0.4	0.5	0.8	-0.7	-0.6	-0.9	-0.6
Alzheimer’s Disease (in father)	1.4	1.5	1.9	1.2	1.2	1.4	1.1
Alzheimer’s Disease (including proxy)	0.2	0.4	0.5	0.5	0.6	0.5	0.7
Crohns Disease (2017)	0.3	0.6	1.0	-1.0	-0.5	-1.0	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-1.0	0.3	-0.2	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.0	-0.1	0.9	0.5	1.0
Major Depression (MDD)	1.4	1.7	2.7	-1.6	-0.8	-1.3	-1.4
Reaction Time	0.8	1.6	2.7	0.9	1.6	1.1	1.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	-0.2	0.3	-0.3
Breast Cancer	0.7	1.7	3.9	2.0	-1.7	-0.2	-0.3
Ovarian Cancer	0.3	0.3	1.2	-1.1	0.1	-0.2	-0.3
Prostate Cancer	0.5	0.8	1.5	0.8	0.3	1.2	0.9
Age at First Birth	0.3	0.5	1.1	0.2	1.1	-0.4	0.8
Bipolar Disorder (2011)	5.1	5.0	8.1	2.9	1.7	2.3	1.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-1.2	-0.3	0.0	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	2.3	0.5	1.5	1.0	0.8
Crohns Disease (2012)	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1
Mean Putamen Volume	0.9	1.1	2.3	-0.6	-1.5	-0.8	-0.9
Fasting Glucose	1.8	2.1	4.8	-2.2	-0.5	-1.4	-1.2
HbA1C	0.1	0.1	0.2	-0.5	-0.1	-0.2	-0.2
HDL Cholesterol	0.3	0.5	1.1	0.4	0.4	1.1	0.7
LDL Cholesterol	2.5	4.0	8.3	-0.3	2.9	1.8	2.0
Lupus	0.2	0.4	1.1	0.5	1.0	0.3	0.3
Neuroticism (2016)	0.2	0.3	0.8	-0.5	0.9	-0.1	0.3
Primary Biliary Cirrhosis	1.0	1.5	3.3	-0.6	-1.8	-1.2	-0.9
Rheumatoid Arthritis	1.9	2.6	4.0	1.5	1.4	1.4	2.0
Schizophrenia (2014)	0.4	1.0	2.0	-0.5	-1.1	-1.4	-0.6
Triglycerides	0.9	1.5	4.1	-0.1	2.0	0.6	1.1
Type 2 Diabetes (T2D) (2012)	1.5	1.7	2.3	-1.1	-1.5	-1.2	-1.4
Ulcerative Colitis	0.5	0.7	1.2	0.4	1.0	0.6	1.1
Blood Eosinophil Count	0.0	0.2	0.3	-0.5	-0.5	0.3	-0.5
Blood Platelet Count	0.0	0.1	0.3	-0.6	-0.4	-0.3	-0.2
Blood Red Count	0.1	1.2	2.6	0.8	1.6	1.1	0.6
Blood White Count	0.4	3.0	6.0	2.4	0.9	1.7	1.5
Heel T-Score	0.7	5.7	9.9	-2.5	-1.4	-3.1	-2.3
BMI	0.1	0.4	0.8	-0.9	0.5	-0.2	-0.8
Height	2.4	46.7	64.6	-5.2	-8.0	-6.0	-7.7
Waist Hip Ratio (WHR)	0.4	1.8	2.5	1.4	1.6	0.8	1.5
Systolic Blood Pressure	0.0	0.2	0.4	0.1	-0.4	0.6	0.2
Smoking Status	0.0	0.1	0.4	0.6	-0.0	0.1	0.2
Allergy or Eczema	1.2	3.2	4.8	1.4	1.4	2.1	2.2
Cardiovascular Disease	0.4	1.2	1.9	-0.7	1.2	0.9	1.4
Hypothyroidism (self reported)	0.1	0.2	0.5	0.0	0.7	0.5	0.2
Respiratory disease	1.3	2.9	3.7	1.4	1.6	1.8	1.9
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	0.2	0.0	0.2
Lung FEV1/FVC ratio	0.2	0.9	2.8	1.7	-0.7	-0.5	-0.3
Lung FVC	0.1	0.6	1.0	-0.9	1.0	-0.8	0.3
Neuroticism	0.9	2.3	4.8	1.0	2.2	0.7	1.7
Chronotype (morning person)	0.2	0.4	1.3	-1.2	-0.2	0.5	-0.4
Hair Pigment	0.1	2.1	2.9	0.5	1.5	1.7	1.7
Tanning	0.0	0.2	0.5	0.7	-0.3	-0.1	0.2
Hand grip strength (left)	2.2	5.8	9.4	-0.9	-3.1	-2.4	-2.7
Number of treatments/medications taken	0.4	0.6	1.0	0.7	0.8	0.7	1.0
Average weekly spirits intake	1.6	1.9	3.7	-0.5	-1.9	-0.9	-1.7
Sensitivity / hurt feelings	2.1	3.6	6.9	0.6	2.6	1.3	2.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.1	-0.5	-0.8	-0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.1	0.6	0.5	0.2
Relative age of first facial hair	0.1	0.1	0.3	0.6	-0.4	-0.2	0.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.1	0.2	0.3	0.6
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.5	-0.4	-0.6	-1.9	-1.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.4	-1.2	-0.6	-0.5
Systolic blood pressure, automated reading	0.1	0.2	0.4	-0.5	-0.5	-0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	3.8	1.5	1.4	1.4	1.9
Angina	0.0	0.1	0.1	-0.1	0.2	-0.3	0.3
Medication for hormone replacement therapy	0.4	0.4	1.1	-1.1	0.6	-0.5	-0.1
Vitamin and mineral supplements	0.0	0.0	0.0	-0.1	0.2	0.1	0.1
Supplements: Zinc	0.3	0.3	0.6	-0.8	-0.6	-0.2	-0.3
Medication: Co-codamol	0.8	0.9	1.8	1.3	1.1	0.4	0.8
Medication: Metformin	0.4	0.6	1.2	-1.1	-0.1	-0.8	-0.8
Diabetes (father)	5.6	7.0	13.1	-3.6	-2.4	-1.7	-2.5
Diabetes (mother)	1.3	1.6	2.4	-1.3	-0.9	-1.3	-1.5
Severe depression (siblings)	2.2	2.5	4.1	1.2	2.0	1.3	1.7
Pack years adult smoking proportion	1.2	1.9	4.3	2.1	1.3	0.9	0.9
Impedance of leg (right)	0.1	0.7	1.9	-0.4	-1.4	-0.7	-0.6
Leg fat-free mass (left)	0.3	1.4	2.3	-1.4	-0.9	-0.6	-1.5
Trunk fat percentage	0.2	0.9	2.8	-0.4	1.7	0.5	0.6
Hand grip strength (right)	2.1	5.6	9.1	-1.4	-3.0	-2.4	-2.4
Townsend deprivation index at recruitment	0.3	0.5	0.9	-0.1	-0.9	-0.6	-0.8
Current tobacco smoking	0.4	0.7	2.3	1.5	0.1	0.5	0.3
Average weekly fortified wine intake	1.1	1.3	3.1	-1.8	-0.3	-1.2	-0.8
Maternal smoking around birth	1.0	1.4	2.2	-0.4	-1.3	-1.5	-1.2
Fed-up feelings	1.2	2.2	3.8	1.5	1.6	0.7	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.7	1.7	0.3	1.1	1.0
Relative age voice broke	0.6	0.9	2.5	-0.5	-0.5	-1.6	-0.7
Taking other prescription medications	1.4	2.2	3.2	1.4	1.8	1.0	1.6
Age when periods started (menarche)	2.8	6.7	8.7	-1.8	-2.9	-2.6	-3.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.5	-0.3	-0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.4	15.5	-3.9	-1.4	-2.3	-2.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	1.0	0.5	0.4	0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.6	-0.6	-0.1	-0.2
Serious illness, injury or assault to yourself	1.9	2.3	3.1	1.8	1.0	1.6	1.6
High blood pressure	0.1	0.2	0.3	-0.1	0.2	0.6	0.6
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.9	0.3	0.8	1.1	1.4
Multivitamins +/- minerals	0.5	0.7	1.1	0.7	0.6	1.0	0.9
Stomach or abdominal pain in last month	0.4	0.6	1.2	-1.1	-0.3	-0.7	-0.6
Supplements: Glucosamine	0.3	0.4	1.0	-0.0	1.0	0.0	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	0.0	0.5	1.1	0.6
Medication: Atenolol	0.0	0.0	0.1	-0.1	0.4	-0.1	-0.1
Medication: Levothyroxine sodium	0.2	0.3	0.4	0.5	0.5	0.3	0.7
Sitting height	1.2	8.2	14.7	-1.9	-3.8	-2.1	-3.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.3
High blood pressure (mother)	0.1	0.2	0.4	-0.2	-0.4	0.6	-0.5
Body mass index (BMI)	0.3	1.2	4.0	-0.2	2.0	0.6	0.6
Impedance of leg (left)	0.1	0.4	1.2	-0.1	-1.1	-0.7	-0.3
Leg predicted mass (left)	0.3	1.6	2.6	-1.5	-1.1	-0.6	-1.6
Trunk fat mass	0.1	0.4	1.1	-1.1	0.7	-0.1	-0.2
Waist circumference	0.1	0.4	1.4	0.1	1.2	0.4	0.1
Number of incorrect matches in round	1.1	1.8	2.7	-1.2	-0.9	-1.6	-1.4
Past tobacco smoking	0.1	0.3	0.6	0.8	-0.6	0.2	-0.2
Alcohol usually taken with meals	0.5	0.8	1.9	-1.4	-0.5	-0.3	-1.0
Nervous feelings	0.2	0.3	0.6	0.5	0.5	0.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	0.2	0.7	0.3	0.9
Hearing difficulty/problems with background noise	1.2	1.9	2.4	1.4	0.9	1.5	1.5
Hair/balding pattern: Pattern 2	1.3	1.7	3.2	-0.9	-1.4	-1.8	-0.8
Had menopause	0.1	0.1	0.3	-0.0	0.2	-0.5	0.0
Had other major operations	1.4	1.8	2.3	-1.2	-1.3	-1.5	-1.2
Forced vital capacity (FVC)	1.5	5.6	7.7	-2.8	-2.1	-2.5	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.2	19.8	-4.5	-1.4	-2.1	-2.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.8	-0.0	0.4	0.1
Qualifications: None of the above	0.7	1.6	4.1	2.0	0.6	1.1	0.8
Financial difficulties in last 2 years	0.9	1.2	2.0	0.8	1.2	0.9	1.4
Mouth/teeth dental problems	0.6	0.9	1.5	-0.7	-1.2	-0.5	-1.2
Heart attack	0.3	0.4	0.8	-0.9	-0.2	-0.6	-0.4
Allergy	0.3	0.7	1.2	-0.8	-0.3	-1.0	-1.1
Pain all over the body in last month	0.8	0.9	1.4	0.8	0.5	1.2	1.1
Diabetes (self-reported)	0.2	0.3	0.5	0.4	0.6	0.5	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.6	-0.9	-0.1	-0.7
Medication: Ramipril	0.6	0.8	1.8	-0.2	-0.7	-1.3	-0.9
Medication: Simvastatin	0.8	1.2	2.0	0.6	1.4	0.9	1.2
Fluid intelligence score	0.4	0.9	1.6	-0.7	-1.3	-0.1	-1.3
Illnesses of siblings	0.2	0.3	0.7	0.8	0.1	0.2	0.8
Neuroticism score	1.1	2.2	4.8	0.9	2.2	0.6	1.7
Weight	0.5	2.3	3.6	-1.9	-0.9	-1.3	-1.8
Impedance of arm (right)	0.1	0.4	0.7	-0.7	-0.8	-0.0	-0.7
Arm fat percentage (right)	0.3	1.2	3.9	-0.5	2.0	0.6	0.5
Trunk fat-free mass	1.4	8.0	10.8	-2.6	-3.0	-2.4	-3.3
Hip circumference	0.4	1.6	3.8	-1.9	-0.3	-0.8	-1.4
Time employed in main current job	0.0	0.0	0.1	-0.3	0.0	0.3	0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.4	0.6	0.6	0.7
Father’s age at death	0.2	0.3	0.5	-0.7	0.7	-0.4	-0.2
Worrier / anxious feelings	0.9	1.6	3.0	0.3	1.7	0.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	5.7	2.4	0.8	1.1	1.3
Falls in the last year	0.1	0.2	0.5	0.1	-0.7	-0.6	0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	0.4	1.2	0.5	0.9
Number of live births	0.1	0.1	0.3	0.5	0.5	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	4.2	-2.0	-1.1	-1.7	-1.2
Pulse rate	0.0	0.1	0.2	0.2	0.5	-0.0	0.0
Happiness	0.4	0.5	1.1	0.9	-1.0	-0.4	-0.0
Noisy workplace	1.2	1.5	2.7	1.1	1.6	0.6	1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.2	0.0	1.0	0.9	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.4	1.1	1.6	0.8	1.2
Mouth/teeth dental problems: Dentures	2.2	3.7	8.3	1.2	2.9	0.8	2.1
Asthma	1.8	3.5	4.2	2.1	1.7	1.7	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.2	0.2	0.1	0.3
Medication: Cholesterol lowering	0.7	1.1	2.0	-0.7	1.4	1.0	0.8
Depression (self-reported)	0.1	0.1	0.2	-0.2	0.1	-0.4	0.2
Medication: Lansoprazole	0.2	0.2	0.6	-0.1	0.4	0.3	0.8
Prospective memory result	2.2	2.7	4.9	-0.5	2.2	1.5	1.9
Lung cancer (father)	1.7	2.0	6.1	2.5	0.6	1.1	0.6
Illnesses of mother	0.3	0.4	1.1	1.0	-0.1	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	6.9	-2.6	-1.6	-2.3	-2.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	-1.0	-0.0	-1.2	-0.7
Impedance of arm (left)	0.1	0.3	0.8	-0.6	-0.9	-0.1	-0.3
Arm fat mass (right)	0.1	0.5	1.1	-0.9	1.1	-0.0	-0.2
Trunk predicted mass	1.4	8.2	11.0	-2.6	-3.0	-2.5	-3.3
Standing height	2.2	21.4	32.5	-3.7	-5.7	-3.9	-4.9
Length of working week for main job	0.5	0.6	1.0	1.0	0.1	0.9	0.7
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.2	-0.4	0.4	-0.6
Breastfed as a baby	0.9	1.1	1.3	-1.1	-1.1	-1.1	-0.8
Tense / ‘highly strung’	0.0	0.1	0.2	0.4	0.2	-0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.5	-0.9	-0.7	-2.1	-0.8
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	0.6	1.0	0.4	0.5
Birth weight of first child	1.0	1.9	3.7	-1.9	-0.8	-1.4	-1.1
Peak expiratory flow (PEF)	0.6	1.4	2.7	-1.6	-0.9	-1.1	-1.0
Pulse wave reflection index	1.2	1.5	2.5	-1.6	-0.0	-1.5	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.1	1.3	0.4	1.1
Loud music exposure frequency	0.3	0.3	0.9	-0.0	0.6	1.0	0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	-0.6	0.9	0.4	1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.9	-1.0	-0.5	0.2	-0.2
Blood clot in the leg (DVT)	0.5	0.6	1.5	0.7	-1.2	-0.1	-0.7
Medication: Paracetamol	0.2	0.3	0.6	0.8	-0.4	0.3	0.5
Headache pain in last month	0.9	1.6	2.5	-0.9	-1.2	-1.6	-1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.2	0.2	-2.1	-1.2	-1.2
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	0.1	0.4	-0.2
Gout (self-reported)	0.1	0.1	0.2	-0.3	0.4	-0.4	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.0	0.5	0.9	1.0	0.8
Medication: Amlodipine	2.5	3.5	5.2	1.2	1.7	2.1	2.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	1.7	1.0	1.3	1.3	1.1
Birth weight	1.3	2.7	4.8	-0.7	-2.2	-1.1	-2.1
Chronic bronchitis/emphysema (mother)	2.9	3.4	4.6	-1.8	-1.7	-2.1	-1.7
High blood pressure (siblings)	0.8	1.2	2.7	-1.6	-0.6	-0.7	-1.1
Forced vital capacity (FVC), Best measure	2.2	8.2	11.5	-3.4	-2.3	-3.0	-2.7
Body fat percentage	0.3	1.3	3.8	-0.2	1.9	0.7	0.9
Leg fat percentage (right)	0.3	1.1	3.5	0.1	1.9	0.5	0.8
Arm fat-free mass (right)	0.7	3.3	4.2	-1.6	-1.9	-1.7	-2.1
Exposure to tobacco smoke outside home	0.2	0.3	0.8	-0.3	-0.5	-0.4	-0.9
Comparative body size at age 10	0.2	0.4	1.0	-0.6	1.0	0.6	0.2
Number of full brothers	0.5	0.7	1.2	0.1	-0.8	-1.1	-0.9
Worry too long after embarrassment	0.5	0.9	1.9	0.2	1.4	0.7	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.2	0.3	-0.6	-1.5	-0.4
Wheeze or whistling in the chest in last year	0.8	1.5	3.9	2.0	0.0	1.2	0.6
Number of children fathered	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.1	-1.0	-0.8	-0.7	-1.0
Age at first live birth	1.5	2.6	5.4	0.1	2.3	1.0	2.0
Pulse wave peak to peak time	0.2	0.2	0.5	0.5	-0.7	0.5	-0.0
Health satisfaction	0.0	0.1	0.1	-0.1	-0.4	0.2	-0.2
Shortness of breath walking on level ground	0.3	0.3	0.4	0.4	0.6	0.5	0.6
Qualifications: College or University degree	1.0	3.1	4.0	-1.3	-1.7	-1.9	-2.0
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	0.3	-0.0	-0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.5	-0.4	-1.1	-1.6	-1.1
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	0.1	0.6	0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.2	0.1	-0.4	-0.4
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.5	-0.2	-0.6	-0.7
Medication: Blood pressure	0.9	1.6	2.2	0.7	1.4	1.5	1.4
Angina (self-reported)	0.1	0.1	0.3	-0.2	-0.0	-0.5	-0.1
Migraine (self-reported)	1.1	1.4	2.0	-1.4	-0.5	-1.2	-1.3
Medication: Ibuprofen	0.0	0.0	0.1	-0.4	-0.0	0.2	0.0
Medication: Allopurinol	0.1	0.2	0.5	-0.7	0.1	0.1	0.4
Medication: Omeprazole	0.5	0.6	1.7	1.3	0.2	0.9	0.1
Medication: Seretide 50 evohaler	3.0	3.5	5.8	2.0	1.5	1.4	2.4
Mean time to correctly identify matches	0.8	1.5	2.7	0.9	1.6	0.8	1.4
Heart disease (mother)	1.0	1.2	1.8	-0.8	-0.9	-1.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	-1.1	-0.6	-0.9	-0.1
Whole body fat mass	0.1	0.5	1.1	-1.1	0.8	-0.1	-0.2
Leg fat mass (right)	0.1	0.3	0.9	-0.6	0.9	-0.1	-0.2
Arm predicted mass (right)	0.5	2.6	3.1	-1.5	-1.6	-1.5	-1.8
Pulse rate, automated reading	0.2	0.7	2.0	-0.2	-0.6	-1.4	-0.6
Alcohol intake frequency.	0.0	0.1	0.2	0.2	0.4	0.1	0.0
Comparative height size at age 10	1.7	9.2	13.1	-3.1	-3.6	-2.1	-3.1
Number of full sisters	0.4	0.5	1.3	1.1	-0.3	0.7	0.3
Suffer from ‘nerves’	0.3	0.5	1.2	-0.3	-0.6	-1.1	-0.5
Overall health rating	0.3	0.7	1.0	0.8	0.6	0.8	1.0
Chest pain or discomfort	0.9	1.2	2.0	-0.8	-1.2	-0.9	-1.4
Had major operations	0.5	0.6	1.1	-1.0	0.9	-0.6	0.1
Age at last live birth	0.2	0.3	0.6	0.1	0.8	-0.3	0.6
Family relationship satisfaction	0.6	0.7	1.5	0.3	1.2	0.5	1.0
Leg pain on walking	0.1	0.2	0.3	-0.5	0.4	-0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	-0.2	-0.1	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	0.0	1.4	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.3	-0.7	-1.5	-0.8	-1.3
Medication: Aspirin	0.5	0.6	1.3	0.3	0.9	1.1	0.6
Supplements: Vitamin C	1.6	1.9	2.7	-1.7	-1.4	-1.0	-1.4
Knee pain experienced in last month	0.5	0.7	1.1	0.6	1.0	0.6	1.0
Hypertension (Self-reported)	0.1	0.2	0.4	-0.3	0.1	0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	0.5	-1.0	-0.5	-0.5
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Illnesses of siblings: Diabetes	3.3	4.0	5.3	-2.0	-1.6	-2.0	-2.3
Smoking status: Previous	0.2	0.3	0.7	-0.9	0.7	-0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.6	11.7	-3.4	-2.4	-2.5	-2.6
Whole body fat-free mass	0.8	4.7	6.6	-2.1	-2.1	-1.7	-2.6
Leg fat-free mass (right)	0.2	1.3	2.2	-1.3	-1.0	-0.6	-1.5
Arm fat percentage (left)	0.3	1.2	3.5	-0.6	1.9	0.6	0.7
Average weekly red wine intake	1.0	1.4	2.0	-1.4	-1.1	-0.7	-1.4
Handedness (chirality/laterality): Left-handed	5.0	6.0	7.6	2.8	2.1	2.1	2.7
Mood swings	1.5	2.8	5.3	1.3	2.3	0.7	1.9
Loneliness, isolation	0.6	0.9	1.3	-0.8	-0.7	-1.1	-1.0
Long-standing illness, disability or infirmity	0.2	0.2	0.5	-0.1	0.7	-0.3	0.6
Ever had bowel cancer screening	0.4	0.4	1.5	-0.3	-0.4	-1.2	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.1	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.7	-0.5	-0.5	-1.6	-1.2
Friendships satisfaction	0.5	0.6	1.1	-0.2	-1.1	-0.9	-0.5
Qualifications: nursing, teaching	0.7	1.1	1.6	0.9	1.3	0.7	1.2
Commuting to job workplace: Walk	1.2	1.3	4.1	0.1	-2.0	-0.3	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.5	1.6	-1.0	0.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.5	0.1	0.5	0.6
Medication for cholesterol	0.7	1.0	1.9	-0.7	-1.4	-0.7	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	1.0	0.1	-0.2	0.7
Back pain experienced in last month	0.6	0.8	1.2	-1.1	-0.7	-1.0	-0.8
Mineral and other dietary supplements	0.1	0.2	0.7	0.2	-0.1	0.8	-0.1
Breast cancer (self-reported)	0.6	0.7	0.9	0.6	0.6	1.0	1.0
Asthma (self-reported)	1.4	2.8	3.6	1.9	1.6	1.4	1.8
Osteoporosis (self-reported)	1.2	1.5	2.4	1.5	0.8	0.8	1.5
Osteoarthritis (self-reported)	1.9	2.5	5.3	-1.5	-0.9	-2.3	-1.3
Medication: Aspirin	0.3	0.4	1.2	0.2	0.6	1.1	0.4
Medication: Gliclazide	2.3	2.6	3.4	-1.7	-1.3	-1.5	-1.9
Illnesses of father: None of the above (group 1)	2.2	2.7	6.4	2.5	1.4	0.7	1.4
Smoking status: Current	0.2	0.3	1.1	1.0	-0.4	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.2	0.0	-0.3	-0.2
Whole body water mass	0.9	5.3	7.3	-2.3	-2.2	-1.9	-2.7
Leg predicted mass (right)	0.2	1.3	2.1	-1.3	-1.0	-0.6	-1.5
Arm fat mass (left)	0.1	0.5	1.1	-1.1	1.0	-0.2	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.4	0.2	0.3	0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.4	-0.8	-0.8	-0.3
Miserableness	0.7	1.2	2.5	0.9	1.6	0.1	1.2
Guilty feelings	0.1	0.1	0.3	-0.6	0.3	-0.1	-0.1
Wears glasses or contact lenses	0.0	0.0	0.1	-0.3	0.1	0.1	-0.2
Ever taken oral contraceptive pill	0.5	0.5	0.9	-0.9	1.0	0.6	0.3
Hearing aid user	0.1	0.1	0.2	0.3	0.0	0.4	-0.0
Mother’s age at death	0.3	0.4	1.3	-0.2	0.3	-1.1	-0.5
Financial situation satisfaction	6.4	7.9	9.8	2.6	3.1	2.4	3.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	-0.1	-0.9	-0.2	0.3
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	-0.2	0.4	0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.4	0.3	0.5	0.1
Medication: Blood pressure	0.2	0.3	0.4	0.7	0.5	0.4	0.5
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.1	-1.7	-0.7	-1.8	-1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.1	-1.3	-1.2	-1.5	-0.8
High cholesterol (Self-reported)	0.5	0.9	2.1	0.5	1.4	0.2	1.1
Medication: Bendroflumethiazide	1.9	2.8	4.9	2.2	0.7	2.1	1.3
Medication: Paracetamol	0.3	0.4	1.2	1.1	-0.1	0.4	0.4
Medication: Lisinopril	4.7	6.0	9.2	2.3	1.9	3.0	2.5
Medication: Atorvastatin	0.4	0.5	1.1	0.6	1.0	0.5	0.6
Illnesses of father: High blood pressure	1.3	1.7	2.8	-1.6	-1.7	-0.3	-1.0
Alcohol drinker status: Never	0.0	0.0	0.1	-0.0	-0.2	0.2	0.3
Ever smoked	0.2	0.3	0.6	-0.6	0.8	-0.2	0.3
Basal metabolic rate	0.8	4.3	6.1	-2.2	-1.9	-1.7	-2.5
Leg fat percentage (left)	0.4	1.4	4.4	0.2	2.1	0.5	0.9
Arm fat-free mass (left)	0.9	4.4	5.8	-2.0	-1.9	-2.0	-2.4
Number of operations (self-reported)	0.2	0.3	0.8	-0.9	-0.1	-0.4	-0.5
Average weekly beer plus cider intake	2.1	3.0	3.6	1.9	1.6	1.6	1.9
Irritability	0.6	1.0	2.4	-1.0	-0.4	-1.6	-0.7
Risk taking	0.2	0.3	0.5	0.1	-0.6	-0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	0.7	0.8	0.4	0.7
Fractured/broken bones in last 5 years	0.4	0.6	1.3	0.6	-1.1	0.7	0.3
Age started oral contraceptive pill	0.6	0.7	1.2	-1.1	-0.2	-1.1	-0.7
Diastolic blood pressure, automated reading	0.2	0.6	1.4	0.4	0.7	0.5	1.2
Ever depressed for a whole week	1.2	1.5	2.6	-0.9	-0.9	-1.6	-1.2
Unable to work because of sickness or disability	4.6	6.0	7.2	2.2	2.5	2.4	2.7
Commuting to job workplace: Cycle	0.2	0.3	1.1	-1.1	0.1	0.0	0.1
Myopia	0.5	0.8	1.5	1.2	0.6	0.5	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.1	-0.5	-0.3	-0.7
Cholesterol lowering medication	0.4	0.6	1.4	1.2	0.6	0.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.2	2.7	1.6	0.5	1.2	0.6
Pain experienced in last month	0.2	0.4	1.0	0.6	0.2	1.0	0.3
Supplements: Calcium	0.7	0.7	2.0	1.4	0.8	0.3	0.5
Basal cell carcinoma (self-reported)	0.9	1.0	2.4	1.6	-1.2	-0.5	-0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-1.0	-0.4	-0.8	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	1.3	-1.0	0.4	-0.2
Heart disease (siblings)	0.1	0.1	0.2	0.1	0.4	0.1	0.3
Alcohol drinker status: Previous	0.8	0.9	1.4	-1.0	-0.6	-1.2	-0.9
Pack years of smoking	1.3	1.9	4.4	2.1	1.3	0.9	1.0
Impedance of whole body	0.1	0.3	0.9	-0.4	-0.9	-0.4	-0.3
Leg fat mass (left)	0.1	0.4	1.2	-0.5	1.1	-0.1	-0.0
Arm predicted mass (left)	0.8	4.1	6.0	-1.8	-1.9	-2.0	-2.5