Hub : Genes

LDLRAD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.4477	0.1027	0.00094	0.253	NA	0.070	NA	0.184	1.2e-06	NA	0.01000	NA	4.2e-05
2	GTEx	Colon Sigmoid	0.2630	0.0890	0.00840	0.002	NA	0.003	NA	0.016	2.7e-01	NA	0.24000	NA	8.6e-02
3	METSIM	Adipose	0.0654	0.0257	0.00350	0.007	0.011	0.025	0.016	0.008	3.0e-02	0.0083	0.00011	0.0018	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.0	3.2	7.1	2.7	0.8	-1.4
Bipolar Disorder or Schizophrenia	0.7	1.7	3.1	1.8	1.0	-1.0
Depressed Affect (Nagel 2018)	0.5	1.0	2.8	-0.1	-1.7	-0.5
Depression (Nagel 2018)	0.3	0.5	1.0	-1.0	-0.2	0.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.2	-0.6	1.5	-0.6
Neuroticism (Nagel 2018)	0.2	0.5	1.3	0.2	-1.1	-0.4
Schizophrenia (2018)	0.1	0.2	0.5	0.1	0.7	-0.2
Schizophrenia vs Biploar Disorder	1.1	1.4	2.6	-0.1	-1.3	1.6
Worry (Nagel 2018)	0.2	0.4	1.1	0.0	-1.1	-0.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	0.6	-1.2	0.4
Alzheimer’s Disease (in father)	1.3	1.4	2.6	-0.6	1.6	-1.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.3	-0.5	-0.0
Crohns Disease (2017)	0.1	0.2	0.4	-0.3	0.6	-0.4
Irritable Bowel Disease (IBD)	0.5	1.1	2.2	-0.1	1.5	-1.0
Ulcerative Colitis (UC)	0.7	1.3	3.0	-0.3	1.7	-0.8
Major Depression (MDD)	0.6	0.7	1.5	-0.1	1.2	-0.8
Reaction Time	1.4	2.6	3.8	-1.4	-1.9	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.5	-1.5	2.1	-0.1
Breast Cancer	0.5	1.3	1.4	1.1	1.1	-1.2
Ovarian Cancer	0.8	1.1	2.4	0.9	1.5	0.2
Prostate Cancer	0.5	0.7	1.9	-0.2	-0.4	-1.4
Age at First Birth	0.5	0.8	1.6	1.3	-0.9	0.0
Bipolar Disorder (2011)	1.1	1.0	2.2	1.5	0.8	-0.6
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	0.5	-0.4	1.4
Coronary Artery Disease (CAD)	0.6	0.7	1.4	0.8	-0.0	1.2
Crohns Disease (2012)	0.3	0.5	1.1	0.3	1.0	0.5
Mean Putamen Volume	0.4	0.5	1.0	0.3	-0.6	-1.0
Fasting Glucose	0.2	0.2	0.4	0.6	-0.4	-0.2
HbA1C	0.5	0.6	0.6	0.8	0.7	-0.8
HDL Cholesterol	0.8	1.3	3.1	-1.8	-0.6	0.6
LDL Cholesterol	0.2	0.3	0.6	0.6	-0.1	-0.8
Lupus	0.8	1.2	3.5	0.3	-1.9	-0.3
Neuroticism (2016)	1.7	2.4	4.6	1.5	-2.1	0.6
Primary Biliary Cirrhosis	0.9	1.3	3.0	1.7	0.8	0.5
Rheumatoid Arthritis	1.2	1.7	2.4	-1.4	1.6	-0.8
Schizophrenia (2014)	0.3	0.6	1.3	1.2	0.3	-0.6
Triglycerides	0.5	0.8	1.5	0.9	1.2	-0.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	3.3	1.8	-0.1	-1.7
Ulcerative Colitis	0.3	0.5	0.7	0.2	0.9	-0.8
Blood Eosinophil Count	0.5	3.9	8.2	-1.6	2.9	-0.9
Blood Platelet Count	0.2	2.0	5.1	0.9	2.3	0.3
Blood Red Count	0.4	3.5	9.8	0.4	0.6	3.1
Blood White Count	0.0	0.3	0.8	0.3	0.9	0.3
Heel T-Score	1.8	14.0	27.9	-3.7	5.3	-0.7
BMI	0.3	2.0	3.2	1.5	-1.8	0.7
Height	0.2	3.5	7.3	-1.0	-1.5	2.7
Waist Hip Ratio (WHR)	0.4	1.8	2.8	1.0	1.3	1.7
Systolic Blood Pressure	0.2	0.9	2.3	0.3	-0.5	-1.5
Smoking Status	0.6	1.4	2.3	-1.5	-0.6	1.2
Allergy or Eczema	0.8	2.1	3.1	-1.7	1.8	-0.4
Cardiovascular Disease	0.2	0.6	1.5	0.5	-0.1	-1.2
Hypothyroidism (self reported)	1.4	3.3	9.2	-3.0	0.8	-0.3
Respiratory disease	0.8	1.8	4.0	-1.2	2.0	-0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.0	1.7	-0.4	-0.6
Lung FEV1/FVC ratio	0.4	2.1	2.8	1.1	-1.7	1.5
Lung FVC	1.6	8.2	18.5	-4.3	-2.5	-0.3
Neuroticism	0.5	1.2	3.1	0.3	-1.8	-0.6
Chronotype (morning person)	1.6	3.6	6.0	-2.4	-1.2	1.9
Hair Pigment	0.0	0.7	1.6	1.3	-0.5	0.2
Tanning	0.4	4.6	11.4	-3.4	1.4	0.7
Hand grip strength (left)	0.3	0.7	1.0	-0.6	-0.8	-1.0
Number of treatments/medications taken	0.1	0.1	0.2	-0.3	0.2	-0.4
Average weekly spirits intake	1.2	1.4	3.0	0.7	0.9	1.7
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.1	0.6	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.8	-0.9	-0.7	0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.4	0.2	-1.2	0.6
Relative age of first facial hair	0.4	0.9	1.6	0.9	-1.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.1	1.0	-0.4	-1.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.4	0.3	-1.8	0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.2	-0.4	0.2
Systolic blood pressure, automated reading	0.7	2.2	3.4	-0.7	-1.6	-1.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	0.4	-1.8	0.1
Angina	0.4	0.5	0.7	-0.9	0.2	-0.9
Medication for hormone replacement therapy	1.8	2.0	3.4	1.8	-1.2	-1.1
Vitamin and mineral supplements	0.4	0.6	1.3	-0.0	1.1	0.7
Supplements: Zinc	0.3	0.3	0.7	-0.3	-0.9	-0.1
Medication: Co-codamol	0.2	0.3	0.5	-0.3	0.5	-0.7
Medication: Metformin	0.4	0.5	1.2	0.4	-1.1	0.5
Diabetes (father)	0.7	0.9	2.2	-0.2	1.5	0.7
Diabetes (mother)	0.2	0.3	0.8	-0.1	-0.2	-0.9
Severe depression (siblings)	0.2	0.2	0.5	-0.1	-0.7	-0.1
Pack years adult smoking proportion	0.3	0.5	1.2	0.2	0.6	1.1
Impedance of leg (right)	0.4	2.1	4.8	0.1	2.2	1.3
Leg fat-free mass (left)	0.3	1.3	2.2	0.8	-1.5	1.0
Trunk fat percentage	0.3	1.2	1.7	1.2	0.5	1.3
Hand grip strength (right)	0.5	1.4	4.1	-2.0	-0.2	-0.1
Townsend deprivation index at recruitment	1.3	1.8	5.0	-0.3	-0.5	-2.2
Current tobacco smoking	0.7	1.1	2.7	-0.8	-1.6	0.1
Average weekly fortified wine intake	1.3	1.6	2.7	-1.6	-0.6	1.3
Maternal smoking around birth	1.2	1.7	3.2	0.5	1.8	-1.3
Fed-up feelings	0.5	0.9	1.4	0.7	-1.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.1	-0.3	0.2
Relative age voice broke	0.7	1.1	2.3	1.0	1.5	-0.1
Taking other prescription medications	0.6	0.9	1.6	-1.3	-1.0	0.2
Age when periods started (menarche)	1.2	2.8	5.8	1.0	2.4	1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	0.0	-0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	-1.4	1.1	0.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.5	-0.2	-1.5	1.6
Qualifications: CSEs or equivalent	0.3	0.4	0.9	1.0	0.4	0.3
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-0.9	-0.4	-0.9
High blood pressure	0.4	1.2	2.8	0.5	-0.7	-1.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	-0.2	1.2	0.1
Multivitamins +/- minerals	0.1	0.2	0.5	0.1	-0.2	-0.7
Stomach or abdominal pain in last month	0.4	0.5	1.0	0.8	-0.1	-1.0
Supplements: Glucosamine	0.8	1.0	1.5	1.2	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.8	0.0	-0.9
Medication: Atenolol	0.7	0.8	1.7	-0.7	0.4	-1.3
Medication: Levothyroxine sodium	0.3	0.6	1.7	-0.2	0.1	-1.3
Sitting height	0.1	1.0	2.1	0.6	-1.4	0.8
Chronic bronchitis/emphysema (father)	1.7	2.0	5.5	-0.1	-2.3	-0.7
High blood pressure (mother)	1.2	1.7	3.2	0.6	1.2	-1.8
Body mass index (BMI)	0.2	0.8	1.7	1.3	-0.3	0.9
Impedance of leg (left)	0.3	1.5	4.4	0.2	2.1	0.4
Leg predicted mass (left)	0.2	1.3	2.2	0.9	-1.5	1.0
Trunk fat mass	0.3	1.4	3.0	1.1	0.2	1.7
Waist circumference	0.4	1.5	2.7	1.3	0.3	1.6
Number of incorrect matches in round	4.9	8.1	20.7	-4.6	-1.4	-1.2
Past tobacco smoking	1.4	2.6	3.8	1.9	-1.0	-1.8
Alcohol usually taken with meals	0.4	0.7	1.8	-1.4	-0.3	-0.4
Nervous feelings	0.4	0.7	1.9	-0.1	-1.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-1.1	0.2	0.4
Hearing difficulty/problems with background noise	0.4	0.6	1.0	0.7	-0.6	-1.0
Hair/balding pattern: Pattern 2	2.4	3.0	4.9	-0.9	2.2	-1.8
Had menopause	1.3	1.7	3.0	-1.0	-1.7	1.0
Had other major operations	1.2	1.4	3.7	1.9	-0.5	0.6
Forced vital capacity (FVC)	0.6	2.4	6.5	-2.6	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	6.1	-2.0	2.5	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.5	-0.1	0.5
Qualifications: None of the above	0.2	0.4	0.6	-0.8	0.6	-0.4
Financial difficulties in last 2 years	1.5	2.0	3.3	1.6	-0.1	-1.8
Mouth/teeth dental problems	0.4	0.6	1.7	-0.2	-0.1	1.3
Heart attack	1.1	1.3	2.0	-1.2	-0.9	1.4
Allergy	0.3	0.6	1.6	0.2	-1.3	-0.3
Pain all over the body in last month	0.7	0.7	1.0	0.6	1.0	0.9
Diabetes (self-reported)	0.2	0.3	0.7	0.3	-0.8	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	-0.2	-1.0	-0.1
Medication: Ramipril	0.3	0.4	0.9	0.9	0.4	0.4
Medication: Simvastatin	0.1	0.1	0.2	0.1	0.2	-0.4
Fluid intelligence score	0.4	0.9	2.5	-0.4	1.6	-0.1
Illnesses of siblings	0.8	1.2	1.6	-1.3	0.9	1.1
Neuroticism score	0.3	0.6	1.2	-0.1	-1.1	0.7
Weight	0.3	1.4	2.2	1.2	-0.6	1.5
Impedance of arm (right)	0.0	0.2	0.4	-0.2	0.7	0.1
Arm fat percentage (right)	0.3	1.0	1.6	1.3	-0.1	1.2
Trunk fat-free mass	0.3	1.6	3.2	0.4	-1.8	1.2
Hip circumference	0.2	0.7	1.3	0.8	0.4	1.1
Time employed in main current job	1.2	1.4	2.2	1.0	-1.5	-1.1
Alcohol intake versus 10 years previously	0.9	1.3	2.4	0.4	-1.5	1.2
Father’s age at death	1.1	1.4	2.8	-1.7	-0.6	1.0
Worrier / anxious feelings	0.0	0.1	0.1	0.0	-0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	0.0	0.2	-0.8
Falls in the last year	1.4	1.9	3.9	-1.2	2.0	0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	-0.5	0.4
Number of live births	0.5	0.7	1.8	-0.4	0.0	-1.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-1.5	-0.8	0.7
Pulse rate	0.9	1.5	4.1	0.4	2.0	-0.2
Happiness	1.4	1.7	3.0	1.7	-0.2	-1.5
Noisy workplace	0.7	0.9	1.0	-1.0	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.0	0.1	1.0	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	1.3	-0.9	0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.7	0.1	0.7
Asthma	0.5	1.0	2.5	-0.6	1.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.3	0.0	1.7	1.8
Medication: Cholesterol lowering	0.2	0.3	0.7	0.3	0.1	-0.8
Depression (self-reported)	1.1	1.3	2.4	-0.4	-1.6	-1.1
Medication: Lansoprazole	0.1	0.1	0.2	0.5	-0.4	-0.2
Prospective memory result	0.7	0.8	1.4	-1.2	-0.6	0.8
Lung cancer (father)	0.2	0.3	0.8	-0.1	0.9	0.3
Illnesses of mother	0.9	1.1	1.8	0.9	0.8	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	6.4	-2.5	-0.9	1.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	1.1	-0.1	0.3
Impedance of arm (left)	0.1	0.6	1.6	-0.5	1.3	0.3
Arm fat mass (right)	0.3	1.2	2.0	1.4	-0.4	1.1
Trunk predicted mass	0.3	1.7	3.3	0.5	-1.8	1.2
Standing height	0.1	1.4	3.6	-0.2	-0.7	1.9
Length of working week for main job	1.5	1.7	2.6	1.2	-1.6	-1.0
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.0	0.1	-0.3
Breastfed as a baby	0.4	0.5	0.9	-0.1	-0.7	0.9
Tense / ‘highly strung’	1.4	2.3	6.3	-0.1	-2.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.1	-1.2	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.7	0.4	-0.1
Birth weight of first child	0.5	0.9	1.6	-1.3	-0.8	0.7
Peak expiratory flow (PEF)	0.3	0.8	1.9	-0.6	1.4	0.2
Pulse wave reflection index	1.2	1.5	2.7	1.0	-1.6	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.2	1.0	0.7
Loud music exposure frequency	2.0	2.2	4.2	-2.0	-0.1	1.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.7	1.6	0.2	-1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	0.8	0.9	0.2	-0.9
Blood clot in the leg (DVT)	0.6	0.8	1.6	0.8	-1.3	-0.3
Medication: Paracetamol	0.5	0.9	2.4	-0.1	-0.3	1.6
Headache pain in last month	0.9	1.5	4.0	-0.8	0.0	2.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.4	-0.4	-1.2	0.4
Glaucoma (self-reported)	1.6	1.9	4.2	0.5	-1.1	-2.0
Gout (self-reported)	1.5	2.1	4.0	1.5	-2.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	1.8	-1.3	1.0	-1.1
Medication: Amlodipine	0.1	0.2	0.5	0.2	-0.2	0.7
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.5	0.3	2.4	0.0
Birth weight	0.8	1.7	3.4	-1.8	-1.4	-0.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	-0.3	-1.1	-0.4
High blood pressure (siblings)	0.9	1.3	1.7	0.9	-1.3	-1.2
Forced vital capacity (FVC), Best measure	1.2	4.5	11.2	-3.3	-1.1	1.1
Body fat percentage	0.4	1.4	2.6	1.2	0.5	1.6
Leg fat percentage (right)	0.7	2.6	5.9	1.0	0.9	2.4
Arm fat-free mass (right)	0.2	0.9	1.4	0.8	-1.2	0.8
Exposure to tobacco smoke outside home	0.9	1.2	2.8	-0.2	0.9	1.7
Comparative body size at age 10	0.6	1.8	4.5	-0.9	-2.1	-0.1
Number of full brothers	0.3	0.4	0.8	-0.9	0.0	0.7
Worry too long after embarrassment	0.7	1.1	2.5	0.8	-0.5	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.3	-0.1	-1.8	0.7
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.3	0.3	-0.6
Number of children fathered	1.3	1.4	2.3	1.1	-1.5	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.2	1.4	-1.6	1.8
Age at first live birth	0.4	0.7	1.9	0.5	-1.4	-0.3
Pulse wave peak to peak time	0.4	0.5	1.2	-1.1	0.4	-0.4
Health satisfaction	1.8	2.3	4.6	1.3	-2.1	-0.8
Shortness of breath walking on level ground	1.6	1.9	2.6	1.6	-0.8	-1.6
Qualifications: College or University degree	0.1	0.2	0.3	-0.4	0.6	-0.2
Eye problems/disorders: None of the above	0.7	0.8	1.5	-0.3	0.9	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.8	0.5	-0.6
Emphysema/chronic bronchitis	0.4	0.5	1.1	0.4	1.1	-0.3
Medication for pain relief, constipation, heartburn	1.1	2.0	5.1	0.7	0.4	-2.3
Neck or shoulder pain in last month	0.6	0.8	1.5	-0.9	0.2	1.2
Medication: Blood pressure	0.1	0.1	0.2	-0.3	0.3	0.5
Angina (self-reported)	0.5	0.7	1.3	-0.9	0.2	-1.1
Migraine (self-reported)	0.4	0.4	1.2	-0.2	-0.2	1.1
Medication: Ibuprofen	1.8	2.1	3.6	0.1	1.9	1.6
Medication: Allopurinol	0.7	0.9	2.4	0.4	-1.5	0.3
Medication: Omeprazole	0.7	0.8	2.3	-1.5	-0.2	-0.4
Medication: Seretide 50 evohaler	0.5	0.6	1.8	-1.3	0.3	0.1
Mean time to correctly identify matches	1.4	2.7	4.3	-2.1	-1.8	-0.9
Heart disease (mother)	0.0	0.1	0.1	-0.3	0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	0.3	0.2	-1.3
Whole body fat mass	0.3	1.5	2.9	1.2	0.0	1.7
Leg fat mass (right)	0.5	2.0	4.7	1.2	-0.0	2.2
Arm predicted mass (right)	0.2	1.1	1.1	1.0	-1.0	1.1
Pulse rate, automated reading	0.9	2.8	5.7	1.7	2.4	0.0
Alcohol intake frequency.	0.5	1.2	3.2	0.5	-1.8	0.4
Comparative height size at age 10	0.3	1.7	2.8	-0.4	-1.7	1.5
Number of full sisters	1.0	1.2	1.9	1.0	-1.4	0.8
Suffer from ‘nerves’	0.5	0.7	1.8	0.5	-1.4	-0.2
Overall health rating	0.8	1.6	2.2	1.4	-1.5	-0.8
Chest pain or discomfort	0.1	0.2	0.3	0.6	-0.3	-0.4
Had major operations	0.5	0.6	1.1	-1.1	-0.9	0.1
Age at last live birth	1.3	1.9	3.8	1.9	-1.4	-0.1
Family relationship satisfaction	0.7	0.8	1.3	-1.1	-0.5	1.0
Leg pain on walking	1.9	2.3	3.2	1.7	-1.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.6	1.9	-0.2	0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.1	-0.9	1.0	0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.4	-1.2	1.2	1.0
Medication: Aspirin	0.2	0.2	0.4	-0.0	-0.6	-0.6
Supplements: Vitamin C	1.0	1.1	1.8	1.1	-1.4	0.6
Knee pain experienced in last month	1.0	1.6	3.7	1.9	-0.7	-0.7
Hypertension (Self-reported)	0.4	1.2	3.0	0.3	-0.7	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.1	0.6	-1.4	-0.2
Illnesses of father: Heart disease	1.3	1.8	3.6	0.8	1.1	-1.9
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.8	-0.4	0.1
Smoking status: Previous	1.1	1.7	2.2	-1.4	0.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.4	-0.8	1.2	1.5
Whole body fat-free mass	0.2	1.4	2.8	0.6	-1.7	1.0
Leg fat-free mass (right)	0.2	1.3	3.2	0.8	-1.8	0.3
Arm fat percentage (left)	0.3	1.4	2.2	1.5	0.1	1.4
Average weekly red wine intake	2.2	3.3	7.8	-1.2	-0.7	-2.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.7	-0.6	1.3	-1.1
Mood swings	0.7	1.3	4.0	0.1	-2.0	-0.0
Loneliness, isolation	0.2	0.2	0.5	-0.3	-0.3	0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.2	-1.3	-0.2
Ever had bowel cancer screening	2.0	2.3	6.2	-0.7	-2.5	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.6	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	4.0	2.0	0.2	-0.1
Friendships satisfaction	0.2	0.2	0.4	-0.6	0.4	0.2
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.1	0.9	0.0
Commuting to job workplace: Walk	2.7	2.9	7.2	2.7	-0.1	-1.2
Eye problems/disorders: Cataract	0.2	0.2	0.2	-0.5	0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.3	-0.6	0.8	-2.3
Medication for cholesterol	1.7	2.5	4.5	-2.1	0.8	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.1	-0.4	0.6
Back pain experienced in last month	0.8	1.2	3.2	1.8	-0.5	-0.2
Mineral and other dietary supplements	0.5	0.7	0.8	-0.8	0.8	0.9
Breast cancer (self-reported)	0.2	0.2	0.6	-0.2	0.8	-0.3
Asthma (self-reported)	0.5	1.0	2.7	-0.5	1.7	0.2
Osteoporosis (self-reported)	0.9	1.2	3.1	-0.4	-0.3	1.8
Osteoarthritis (self-reported)	1.0	1.3	2.2	0.7	-1.2	1.5
Medication: Aspirin	0.5	0.7	1.1	-0.4	-0.9	-1.1
Medication: Gliclazide	0.2	0.2	0.3	0.5	0.2	-0.6
Illnesses of father: None of the above (group 1)	2.1	2.6	4.8	-1.5	0.8	2.2
Smoking status: Current	0.7	1.0	2.2	-0.9	-1.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.6	-2.8	-1.7	0.9
Whole body water mass	0.2	1.3	2.8	0.7	-1.7	0.8
Leg predicted mass (right)	0.2	1.3	3.2	0.8	-1.8	0.2
Arm fat mass (left)	0.3	1.4	2.1	1.4	-0.2	1.4
Number of self-reported non-cancer illnesses	0.5	0.9	2.2	-0.6	-1.5	-0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.3	0.9	0.3
Miserableness	1.3	2.2	4.8	-2.2	-1.3	-0.1
Guilty feelings	0.7	1.1	1.9	-0.5	-1.4	1.0
Wears glasses or contact lenses	0.3	0.3	0.5	0.4	-0.6	0.7
Ever taken oral contraceptive pill	0.7	0.8	1.4	1.2	0.3	-1.0
Hearing aid user	0.2	0.3	0.7	0.9	-0.0	-0.3
Mother’s age at death	1.1	1.4	2.0	1.3	-1.4	-0.5
Financial situation satisfaction	1.9	2.3	5.3	0.9	-0.9	-2.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.5	-0.1	-0.3
Commuting to job workplace: Public transport	1.0	1.2	2.0	1.4	-1.0	-0.8
Eye problems/disorders: Glaucoma	2.4	2.9	7.2	-0.3	-1.1	-2.7
Medication: Blood pressure	0.6	1.1	1.7	1.2	-0.1	-1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	0.2	0.0	1.4
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.0	-0.2	-1.7	-0.1
High cholesterol (Self-reported)	0.2	0.3	0.5	-0.7	0.2	-0.7
Medication: Bendroflumethiazide	0.5	0.8	2.2	1.5	0.4	0.2
Medication: Paracetamol	0.7	1.0	2.8	0.3	-0.4	1.7
Medication: Lisinopril	0.1	0.2	0.4	0.2	-0.0	-0.7
Medication: Atorvastatin	0.3	0.4	0.7	-0.5	-0.8	-0.5
Illnesses of father: High blood pressure	1.4	1.8	4.5	0.5	-0.8	-2.1
Alcohol drinker status: Never	0.8	0.9	2.1	1.5	-0.8	-0.2
Ever smoked	2.2	3.8	6.0	-2.3	0.4	2.4
Basal metabolic rate	0.2	1.4	2.0	1.0	-1.4	1.1
Leg fat percentage (left)	0.5	1.8	3.5	1.0	0.9	1.9
Arm fat-free mass (left)	0.3	1.5	2.3	1.1	-1.5	0.9
Number of operations (self-reported)	0.2	0.3	1.0	-0.2	-1.0	0.0
Average weekly beer plus cider intake	0.6	0.8	2.0	-1.4	0.6	0.3
Irritability	0.0	0.1	0.1	0.4	-0.3	0.2
Risk taking	0.3	0.4	0.6	-0.8	-0.2	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.6	0.8	0.2	0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.4	0.6	0.6	-0.1
Age started oral contraceptive pill	1.2	1.6	2.2	1.5	-1.5	-0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.4	-0.0	1.2	0.5
Ever depressed for a whole week	0.1	0.1	0.2	0.2	0.1	0.4
Unable to work because of sickness or disability	0.7	0.9	1.5	-1.2	-1.2	0.2
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.0	0.6	-0.5
Myopia	0.3	0.4	0.7	0.1	-0.8	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.3	0.0	0.4	1.5
Cholesterol lowering medication	0.4	0.6	1.1	-1.1	-0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-1.3	-0.7	-0.1
Pain experienced in last month	0.1	0.2	0.6	0.1	0.3	-0.8
Supplements: Calcium	0.5	0.6	1.6	0.2	-1.2	-0.4
Basal cell carcinoma (self-reported)	0.5	0.5	1.2	1.1	-0.2	0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.7	-1.3	-0.6	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	1.0	-1.1	-0.0
Heart disease (siblings)	0.7	0.8	2.2	0.1	0.5	-1.5
Alcohol drinker status: Previous	1.2	1.4	1.8	-1.2	-1.3	0.9
Pack years of smoking	0.4	0.6	1.4	-0.2	0.6	1.2
Impedance of whole body	0.3	1.5	4.3	-0.0	2.1	0.4
Leg fat mass (left)	0.4	1.6	3.5	1.2	0.1	1.9
Arm predicted mass (left)	0.3	1.3	2.3	0.9	-1.5	0.9