Hub : Genes

LINC00092

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.153	0.0560	7.4e-03	0.107	NA	0.047	NA	0.075	4.3e-09	NA	1.0e-04	NA	9.4e-07
2	GTEx	Colon Sigmoid	0.364	0.1110	2.5e-03	0.003	NA	0.003	NA	-0.006	2.4e-01	NA	2.5e-01	NA	6.3e-01
3	GTEx	Esophagus Mucosa	0.159	0.0570	4.5e-03	0.006	NA	0.002	NA	0.003	1.2e-01	NA	2.2e-01	NA	1.9e-01
4	GTEx	Skin Sun Exposed Lower leg	0.097	0.0370	2.9e-03	-0.001	NA	-0.003	NA	-0.003	4.2e-01	NA	7.3e-01	NA	1.0e+00
5	METSIM	Adipose	0.104	0.0297	5.5e-07	0.083	0.058	0.086	0.08	0.093	2.3e-12	5.1e-09	9.1e-13	4.6e-12	9.6e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.7	2.0	-1.4	-0.7	0.4	0.7	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.6	1.5	-1.2	0.1	1.1	-0.0	-0.6
Depressed Affect (Nagel 2018)	0.5	1.0	4.5	-0.7	-2.1	0.2	0.1	-0.0
Depression (Nagel 2018)	0.8	1.2	1.7	-1.3	-1.1	-1.2	-0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.9	5.5	-1.7	0.7	2.3	-0.3	-0.8
Neuroticism (Nagel 2018)	0.6	1.4	6.1	-0.8	-2.5	-0.4	0.3	-0.1
Schizophrenia (2018)	0.2	0.4	1.0	-0.4	0.7	1.0	-0.6	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.2	0.5	-0.5	-0.1	-0.4	0.3
Worry (Nagel 2018)	0.7	1.4	5.1	-0.2	-2.3	-1.3	-0.1	-0.0
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	-1.0	0.7	-0.0	-1.0	-1.4
Alzheimer’s Disease (in father)	0.7	0.8	2.1	1.4	-0.9	-0.9	-0.4	0.5
Alzheimer’s Disease (including proxy)	0.5	0.8	2.3	0.1	0.7	-0.7	-1.5	-0.8
Crohns Disease (2017)	0.5	1.1	2.4	0.7	-0.7	1.5	-0.3	1.5
Irritable Bowel Disease (IBD)	0.8	1.8	6.6	0.6	-0.2	2.6	-0.6	1.3
Ulcerative Colitis (UC)	0.6	1.2	5.1	-0.1	0.1	2.2	-0.9	0.3
Major Depression (MDD)	1.2	1.4	6.3	-0.7	0.2	-2.5	-0.6	-0.1
Reaction Time	0.3	0.6	1.9	0.4	0.3	1.4	0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.1	-0.7	-0.3	1.5	1.0	0.1
Breast Cancer	0.4	1.0	2.1	0.7	-0.5	-0.4	1.4	1.4
Ovarian Cancer	0.7	1.0	4.3	-0.4	-0.4	-2.1	0.2	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.4	2.0	5.1	1.1	-2.3	0.2	1.4	1.3
Bipolar Disorder (2011)	1.4	1.4	4.3	0.0	-1.3	-0.9	-2.1	0.0
Body Mass Index (BMI) (2010)	0.8	1.2	4.7	-0.4	0.0	2.2	0.8	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.0	0.5	0.3	-0.4	-0.3
Crohns Disease (2012)	0.2	0.3	0.8	-0.3	-0.2	0.6	-0.4	0.9
Mean Putamen Volume	0.9	1.0	4.5	0.5	2.1	0.2	0.5	-0.1
Fasting Glucose	1.1	1.3	4.0	0.6	2.0	-1.4	-0.6	-0.0
HbA1C	0.9	1.0	4.2	-0.3	0.5	-2.0	-0.1	0.5
HDL Cholesterol	1.3	2.1	4.2	2.0	1.5	1.3	0.8	1.4
LDL Cholesterol	0.2	0.3	1.1	-0.1	0.1	-1.1	-0.7	-0.2
Lupus	1.1	1.7	5.7	-0.9	-0.2	-0.5	-2.4	-1.2
Neuroticism (2016)	0.5	0.8	1.7	0.2	-1.1	1.3	0.3	1.0
Primary Biliary Cirrhosis	0.9	1.3	5.6	-0.5	0.5	2.4	-0.1	-0.4
Rheumatoid Arthritis	0.1	0.1	0.1	0.4	0.3	0.3	0.3	0.3
Schizophrenia (2014)	0.1	0.2	0.6	-0.1	0.3	0.8	-0.1	0.5
Triglycerides	0.6	0.9	2.4	0.4	1.1	-1.6	0.5	0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	-1.0	-0.1	-0.5	0.2	-1.3
Ulcerative Colitis	0.6	0.9	1.9	-1.4	0.8	0.9	-0.7	-0.7
Blood Eosinophil Count	0.2	1.4	6.2	0.6	2.5	-0.2	-0.6	0.0
Blood Platelet Count	0.4	4.9	14.0	2.2	-0.8	-1.0	3.7	2.0
Blood Red Count	0.2	2.0	5.2	1.4	2.3	1.2	1.1	0.6
Blood White Count	1.2	9.2	16.2	4.0	4.0	0.4	1.3	3.5
Heel T-Score	0.0	0.3	0.8	0.9	-0.5	-0.2	-0.8	-0.0
BMI	0.5	2.6	7.3	1.4	1.6	2.7	0.3	1.0
Height	1.4	26.8	73.1	-4.6	-2.5	-8.6	-2.4	-5.3
Waist Hip Ratio (WHR)	0.6	2.9	6.9	1.5	1.7	-2.6	-1.5	0.7
Systolic Blood Pressure	0.3	1.5	5.5	-0.6	-0.1	2.4	0.0	-1.3
Smoking Status	0.4	0.9	1.8	-1.3	-0.5	-0.2	-0.9	-1.3
Allergy or Eczema	0.2	0.6	1.0	0.6	-0.6	0.7	0.8	1.0
Cardiovascular Disease	0.6	2.0	3.8	-1.8	-1.4	0.5	-1.0	-1.9
Hypothyroidism (self reported)	0.5	1.1	4.5	-0.0	0.5	2.1	-0.8	0.5
Respiratory disease	0.3	0.7	1.7	0.9	0.9	0.4	0.3	1.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.0	-0.6	0.7	-1.4	0.9	0.0
Lung FEV1/FVC ratio	0.7	3.8	10.6	0.0	-0.3	3.2	1.8	-2.2
Lung FVC	1.2	5.9	15.6	0.7	-3.3	-4.0	-0.3	1.5
Neuroticism	0.8	1.9	7.2	0.4	-2.7	-1.1	0.2	0.8
Chronotype (morning person)	0.3	0.8	3.3	-0.2	-0.3	-1.8	-0.6	-0.3
Hair Pigment	0.0	0.2	0.7	-0.6	0.8	0.0	-0.0	-0.0
Tanning	0.1	1.8	4.4	0.7	-0.2	2.1	1.5	1.4
Hand grip strength (left)	1.1	2.9	6.6	-2.6	-1.7	1.0	0.9	-1.7
Number of treatments/medications taken	0.5	0.9	2.1	0.6	-1.5	-1.2	-0.2	0.7
Average weekly spirits intake	1.7	2.1	4.3	1.3	2.1	0.9	1.1	1.6
Sensitivity / hurt feelings	1.0	1.8	7.6	0.2	-2.8	-0.9	0.5	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.5	-0.1	-0.6	-0.5	0.8
Hearing difficulty/problems: Yes	1.3	2.0	5.2	-0.3	1.4	1.5	-2.3	-0.8
Relative age of first facial hair	0.6	1.2	4.7	0.8	-2.2	0.5	0.0	0.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.0	-0.7	-0.0	-0.7	-1.0	-0.8
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.3	2.1	-0.7	-1.9	0.4	1.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.4	-0.7	-0.9	-0.4	-0.2
Systolic blood pressure, automated reading	0.2	0.7	1.8	0.3	0.6	1.3	1.0	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	0.2	0.0	0.7	0.0	1.0
Angina	1.1	1.4	2.9	-0.7	-0.7	1.7	-1.5	-1.0
Medication for hormone replacement therapy	1.5	1.7	2.8	1.7	-0.9	-1.6	0.6	1.5
Vitamin and mineral supplements	0.8	1.0	2.5	0.6	1.6	1.5	-0.2	0.2
Supplements: Zinc	1.5	1.6	2.7	-1.6	1.3	0.8	-0.6	-1.6
Medication: Co-codamol	3.2	3.7	7.3	2.7	0.8	-1.1	1.8	2.5
Medication: Metformin	0.4	0.5	2.1	0.1	-0.3	-1.4	0.3	0.5
Diabetes (father)	0.3	0.4	1.3	0.1	0.6	-1.2	-0.4	-0.2
Diabetes (mother)	1.2	1.6	5.3	0.0	1.5	-2.3	-0.2	-0.4
Severe depression (siblings)	2.1	2.4	7.8	2.8	1.0	0.1	0.9	1.5
Pack years adult smoking proportion	0.1	0.2	0.4	-0.7	0.5	0.2	-0.1	-0.5
Impedance of leg (right)	0.5	2.6	6.3	2.0	2.5	-1.5	-0.3	0.6
Leg fat-free mass (left)	0.6	3.0	6.2	-2.4	-2.5	-0.4	-0.2	-1.7
Trunk fat percentage	0.3	1.1	2.2	1.0	1.5	0.8	-1.1	-0.0
Hand grip strength (right)	1.1	3.1	8.2	-2.9	-2.0	0.2	0.9	-1.6
Townsend deprivation index at recruitment	1.6	2.2	8.3	1.0	2.9	-0.1	1.2	0.6
Current tobacco smoking	0.5	0.8	1.2	-1.1	0.8	0.2	-0.9	-1.1
Average weekly fortified wine intake	0.3	0.4	1.4	-0.2	-0.6	-1.2	0.0	0.3
Maternal smoking around birth	0.7	1.0	2.5	1.3	0.2	-0.7	0.2	1.6
Fed-up feelings	0.2	0.4	0.9	-0.5	-0.9	-0.2	0.8	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.2	2.3	-0.1	-1.7	-0.3	1.8
Relative age voice broke	1.8	2.8	7.3	0.9	-2.0	0.5	2.7	1.1
Taking other prescription medications	0.6	0.9	3.0	0.8	0.7	-1.7	0.1	0.6
Age when periods started (menarche)	0.5	1.1	4.1	-0.2	-1.2	-0.3	2.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	4.0	-0.0	-2.0	0.3	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.3	-1.1	-1.1	-0.9	-0.9	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.1	0.6	-0.1	-1.0	-1.5	-0.5
Qualifications: CSEs or equivalent	0.6	0.8	1.8	0.8	-0.1	-1.2	1.4	-0.4
Serious illness, injury or assault to yourself	1.0	1.2	2.2	0.7	-0.5	-1.0	1.5	1.4
High blood pressure	0.9	2.4	4.5	-1.8	-1.1	-0.2	-1.7	-2.1
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.9	0.4	0.0	0.9	0.5	0.6
Multivitamins +/- minerals	1.5	1.9	3.9	-1.2	-2.0	-1.7	-0.2	-1.2
Stomach or abdominal pain in last month	1.0	1.3	4.5	0.5	-2.1	0.2	0.9	0.9
Supplements: Glucosamine	1.8	2.4	3.5	1.9	-0.3	-1.7	1.8	1.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.3	1.0	-0.8	1.5	-0.4	0.9
Medication: Atenolol	1.4	1.7	3.1	-1.8	-1.2	0.9	-0.6	-1.7
Medication: Levothyroxine sodium	0.5	0.8	1.3	-1.2	-0.3	0.8	-0.8	-1.1
Sitting height	1.0	6.9	14.2	-2.7	-3.8	-2.4	0.7	-2.6
Chronic bronchitis/emphysema (father)	0.6	0.8	3.1	0.1	-0.2	-1.8	0.7	-0.4
High blood pressure (mother)	0.7	0.9	4.3	-0.4	-0.4	2.1	-0.1	0.0
Body mass index (BMI)	0.4	1.7	4.3	1.4	1.1	2.1	-0.2	1.1
Impedance of leg (left)	0.6	2.7	6.3	2.1	2.5	-1.5	-0.3	0.6
Leg predicted mass (left)	0.5	2.9	6.0	-2.3	-2.4	-0.4	-0.3	-1.7
Trunk fat mass	0.1	0.4	1.0	0.1	0.7	0.3	-1.0	-0.6
Waist circumference	0.2	0.6	1.6	1.0	1.3	-0.3	-0.7	0.1
Number of incorrect matches in round	0.7	1.2	1.5	1.2	1.1	-1.1	-0.8	1.1
Past tobacco smoking	0.0	0.1	0.1	-0.3	0.3	0.4	0.2	-0.0
Alcohol usually taken with meals	0.3	0.5	1.5	0.5	0.9	1.2	0.2	0.2
Nervous feelings	0.3	0.6	2.7	0.2	-1.6	0.3	-0.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.6	0.3	-1.9	-0.9	1.1	0.8
Hearing difficulty/problems with background noise	0.8	1.3	4.8	0.3	1.3	0.3	-2.2	-0.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.4	-0.1	0.1	0.9	-0.3
Had menopause	0.4	0.5	1.9	-0.1	-0.6	-1.4	0.5	-0.2
Had other major operations	0.8	1.0	1.8	1.3	0.5	-0.5	1.3	0.9
Forced vital capacity (FVC)	1.8	6.8	19.0	0.1	-3.8	-4.4	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.9	-1.2	-0.7	-0.5	-1.4	-1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	2.7	1.6	0.6	-0.9	0.8	1.1
Qualifications: None of the above	0.4	0.8	1.6	-0.7	0.8	0.2	-1.3	-1.2
Financial difficulties in last 2 years	0.2	0.3	0.7	0.1	-0.8	-0.8	0.4	0.0
Mouth/teeth dental problems	0.7	1.1	2.5	-0.6	-1.5	-1.6	0.4	-0.5
Heart attack	0.8	1.0	2.8	-0.4	1.7	1.2	-0.7	-0.3
Allergy	0.5	1.2	2.1	-1.2	-1.2	-1.0	-0.2	-1.4
Pain all over the body in last month	0.8	0.8	1.5	1.0	1.2	0.8	0.4	0.9
Diabetes (self-reported)	0.6	0.9	2.9	0.0	1.7	-1.2	-0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.5	-0.2	1.2	0.7	-1.1	0.0
Medication: Ramipril	0.5	0.7	1.6	-0.2	1.0	-0.5	-1.3	-0.6
Medication: Simvastatin	1.7	2.5	4.3	-2.1	0.4	-0.2	-1.9	-2.0
Fluid intelligence score	0.6	1.3	4.8	-0.6	0.1	2.2	1.1	0.4
Illnesses of siblings	0.7	1.0	1.5	1.2	1.0	-0.6	1.2	0.9
Neuroticism score	0.8	1.7	5.7	1.0	-2.4	-0.5	0.5	1.2
Weight	0.1	0.3	0.4	-0.4	-0.4	-0.5	-0.6	-0.6
Impedance of arm (right)	0.3	1.3	3.9	0.7	1.1	-2.0	-0.8	-0.6
Arm fat percentage (right)	0.5	1.9	3.2	1.8	1.5	1.6	-0.6	1.1
Trunk fat-free mass	0.6	3.4	5.8	-2.1	-2.4	-2.0	0.1	-1.6
Hip circumference	0.0	0.2	0.4	-0.3	-0.3	0.6	0.4	-0.6
Time employed in main current job	0.2	0.2	0.5	-0.3	0.6	0.7	0.5	-0.0
Alcohol intake versus 10 years previously	0.3	0.5	1.3	-1.1	-0.1	0.0	0.1	-1.2
Father’s age at death	0.4	0.6	1.6	1.3	0.6	-0.2	0.2	1.0
Worrier / anxious feelings	0.2	0.4	1.0	0.1	-1.0	-1.0	0.3	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.1	1.8	0.9	-2.5	0.1	1.3
Falls in the last year	1.4	1.9	4.6	2.1	1.0	-0.6	1.1	1.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.7	-0.4	-0.1	0.5	1.6	0.7
Number of live births	0.4	0.6	1.3	-0.7	0.3	-0.4	-1.1	-1.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	14.0	-0.3	-3.7	-2.9	1.3	-0.2
Pulse rate	0.6	1.1	4.9	0.6	2.2	0.3	-0.2	0.1
Happiness	0.3	0.4	1.1	0.7	1.1	0.2	0.1	0.5
Noisy workplace	1.6	1.9	8.4	-0.5	-2.9	-0.4	0.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.7	-0.0	-0.1	0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	-0.2	-0.1	0.3	0.2	-0.3
Mouth/teeth dental problems: Dentures	0.9	1.6	3.1	-1.6	0.9	0.9	-0.7	-1.8
Asthma	0.5	0.9	2.1	1.0	0.8	1.0	-0.1	1.5
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.0	9.0	3.0	-0.8	-0.9	1.4	2.8
Medication: Cholesterol lowering	1.2	1.8	3.7	-1.8	-0.8	-0.1	-1.2	-1.9
Depression (self-reported)	3.0	3.6	6.9	2.6	0.3	-2.3	1.1	2.1
Medication: Lansoprazole	0.1	0.1	0.5	0.0	-0.4	-0.7	0.2	0.2
Prospective memory result	1.1	1.3	4.5	1.3	0.5	-2.1	-0.3	0.5
Lung cancer (father)	1.0	1.2	3.6	1.2	-0.4	-1.9	0.3	0.7
Illnesses of mother	0.1	0.1	0.3	0.1	0.2	0.2	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	19.0	0.2	-4.4	-2.2	1.4	-0.1
Pulse wave Arterial Stiffness index	0.1	0.2	0.6	-0.2	-0.5	0.0	0.7	-0.1
Impedance of arm (left)	0.3	1.6	3.7	-0.0	1.4	-1.9	-1.0	-1.1
Arm fat mass (right)	0.2	0.8	1.2	1.1	0.9	1.0	-0.6	0.6
Trunk predicted mass	0.6	3.3	5.4	-2.2	-2.3	-2.0	0.1	-1.6
Standing height	1.3	13.4	27.4	-3.7	-3.2	-5.2	-1.1	-3.8
Length of working week for main job	1.1	1.2	2.7	1.2	0.5	0.4	1.6	1.2
Exposure to tobacco smoke at home	0.8	0.9	2.7	0.6	-0.8	-0.0	1.6	0.8
Breastfed as a baby	1.2	1.5	3.5	0.5	1.9	1.1	1.5	0.6
Tense / ‘highly strung’	0.7	1.1	2.6	1.0	-0.5	-1.6	-1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	1.3	-0.9	0.4	1.4	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.8	-0.5	0.9	0.2	-1.3	-0.7
Birth weight of first child	1.7	3.0	7.4	-0.7	1.4	-1.9	-2.7	-1.2
Peak expiratory flow (PEF)	1.0	2.4	7.8	-0.0	-2.8	0.1	2.0	0.1
Pulse wave reflection index	0.6	0.7	1.8	-0.5	-1.3	-1.1	0.6	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.9	0.1	0.5	-0.0	1.1
Loud music exposure frequency	2.2	2.4	4.5	-1.6	-2.1	1.5	-0.6	-1.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.5	0.4	-0.2	0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.1	1.0	0.0	0.6	0.6	1.4
Blood clot in the leg (DVT)	1.3	1.6	4.0	1.3	2.0	-1.3	0.2	0.7
Medication: Paracetamol	0.6	1.0	2.2	1.2	-1.5	-0.0	-0.4	1.1
Headache pain in last month	0.8	1.3	2.5	1.6	0.6	-0.6	1.1	1.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.2	1.7	1.2	0.8	1.6	1.8
Glaucoma (self-reported)	0.9	1.0	1.8	0.7	1.3	-1.3	-1.0	0.4
Gout (self-reported)	0.6	0.9	2.1	-1.5	0.8	-0.9	-0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.7	0.1	0.6	1.9	-0.3	0.5
Medication: Amlodipine	1.0	1.4	2.7	-1.1	-1.6	-1.3	-0.6	-1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.1	0.8	0.3	-0.2	0.6
Birth weight	0.4	0.9	1.6	-1.0	-1.0	0.2	-1.3	-0.8
Chronic bronchitis/emphysema (mother)	2.3	2.7	5.5	1.9	0.2	0.3	2.0	2.4
High blood pressure (siblings)	0.2	0.2	0.6	-0.3	-0.7	0.6	-0.2	0.3
Forced vital capacity (FVC), Best measure	2.0	7.4	21.2	0.2	-4.6	-3.9	0.7	0.4
Body fat percentage	0.4	1.7	3.7	1.4	1.9	1.4	-0.9	0.4
Leg fat percentage (right)	0.8	3.0	5.7	2.2	2.4	1.7	-0.1	1.3
Arm fat-free mass (right)	0.5	2.4	4.3	-2.1	-2.0	-0.8	-0.3	-1.6
Exposure to tobacco smoke outside home	0.6	0.7	2.5	-0.7	1.6	0.8	-0.1	-0.3
Comparative body size at age 10	0.4	1.0	2.7	0.1	1.6	1.0	-0.3	1.1
Number of full brothers	1.8	2.3	6.4	-1.2	1.2	1.0	-1.0	-2.5
Worry too long after embarrassment	0.4	0.7	1.2	0.4	-0.6	0.9	1.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	5.5	2.3	-0.5	-2.1	1.5	2.0
Wheeze or whistling in the chest in last year	0.7	1.2	4.3	0.1	0.6	2.1	0.5	1.1
Number of children fathered	0.5	0.5	2.0	-0.2	0.4	-0.6	-1.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	-0.7	-0.9	0.4	0.4	-0.8
Age at first live birth	0.5	1.0	2.0	-1.4	-1.3	0.3	-0.8	-0.5
Pulse wave peak to peak time	0.1	0.1	0.4	-0.1	0.3	-0.3	-0.6	-0.1
Health satisfaction	0.4	0.5	1.4	1.2	0.1	1.0	-0.2	0.2
Shortness of breath walking on level ground	0.2	0.3	0.9	-0.6	0.4	-0.1	-0.3	-0.9
Qualifications: College or University degree	0.3	0.8	2.7	-1.6	-0.4	1.0	0.4	-0.1
Eye problems/disorders: None of the above	1.6	1.8	4.7	-1.8	0.8	-0.7	-0.6	-2.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.8	0.7	0.1	1.4	-0.2	0.5
Emphysema/chronic bronchitis	0.3	0.4	0.9	0.5	1.0	-0.1	-0.0	0.7
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	-1.4	1.3	0.5	0.2	-1.4
Neck or shoulder pain in last month	2.4	3.4	8.3	2.9	-0.1	0.4	0.8	2.8
Medication: Blood pressure	1.1	1.9	3.1	-1.7	-0.8	-0.4	-1.7	-1.8
Angina (self-reported)	1.0	1.3	2.5	-0.8	-0.8	1.6	-1.3	-1.1
Migraine (self-reported)	1.0	1.2	2.6	1.3	0.1	1.3	0.6	1.6
Medication: Ibuprofen	2.0	2.4	5.0	2.2	-0.8	-1.3	0.9	1.9
Medication: Allopurinol	0.5	0.6	1.5	-1.2	0.1	-0.7	-0.2	-1.0
Medication: Omeprazole	0.7	0.8	1.7	-0.6	0.3	-0.9	-1.3	-1.0
Medication: Seretide 50 evohaler	1.1	1.2	4.3	-1.1	-0.3	2.1	-0.2	-0.6
Mean time to correctly identify matches	0.2	0.4	1.0	0.5	0.9	1.0	-0.0	0.1
Heart disease (mother)	1.2	1.4	2.6	1.6	0.8	-1.0	1.2	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	7.3	-2.7	0.4	0.6	-0.4	-2.1
Whole body fat mass	0.1	0.5	1.0	0.3	1.0	0.7	-0.8	-0.3
Leg fat mass (right)	0.2	0.8	1.9	0.7	1.1	1.4	-0.8	0.2
Arm predicted mass (right)	0.5	2.6	4.9	-2.2	-2.1	-0.7	-0.0	-1.6
Pulse rate, automated reading	0.5	1.5	7.1	-0.0	2.7	0.6	-0.3	-0.3
Alcohol intake frequency.	1.6	3.7	8.8	-1.9	-0.1	-1.9	-1.7	-3.0
Comparative height size at age 10	1.6	8.6	14.5	-3.2	0.7	-3.8	-2.2	-3.5
Number of full sisters	0.3	0.3	0.7	0.7	0.8	0.5	0.6	0.1
Suffer from ‘nerves’	0.8	1.2	2.2	1.1	-1.2	1.5	0.3	1.0
Overall health rating	0.6	1.2	4.0	2.0	0.4	-0.4	0.6	1.2
Chest pain or discomfort	0.3	0.4	1.2	0.7	-0.5	0.1	0.2	1.1
Had major operations	1.0	1.2	4.3	0.6	0.9	-2.1	0.4	0.5
Age at last live birth	1.4	2.1	5.0	-2.2	-0.8	1.5	-0.8	-1.4
Family relationship satisfaction	0.3	0.4	1.2	-0.2	-0.9	1.1	-0.1	0.1
Leg pain on walking	0.3	0.3	0.8	0.9	0.3	-0.3	-0.5	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.4	1.3	-0.7	-1.8	0.1	0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.4	1.0	-0.3	-0.0	0.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.5	0.1	-0.3	0.2	0.5
Medication: Aspirin	0.2	0.2	0.9	-0.1	-0.1	-1.0	-0.4	0.2
Supplements: Vitamin C	0.5	0.6	2.6	-0.4	0.2	-1.6	-0.6	-0.3
Knee pain experienced in last month	0.3	0.5	1.1	1.0	-0.5	-1.0	-0.2	0.3
Hypertension (Self-reported)	0.7	1.9	3.6	-1.7	-0.9	-0.7	-1.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.3	1.8	2.1	-0.1	-0.1	1.7
Illnesses of father: Heart disease	0.3	0.5	1.6	-0.3	-0.3	0.7	-1.3	-0.2
Illnesses of siblings: Diabetes	1.0	1.3	2.6	-1.6	-0.7	-0.8	-0.7	-1.5
Smoking status: Previous	0.3	0.4	0.9	0.6	-1.0	-0.3	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.1	8.9	-1.5	-2.8	-3.0	-1.2	-2.2
Whole body fat-free mass	0.5	3.1	5.9	-2.2	-2.4	-1.4	-0.0	-1.7
Leg fat-free mass (right)	0.6	3.2	6.6	-2.4	-2.6	-0.6	-0.1	-1.7
Arm fat percentage (left)	0.5	1.8	3.1	1.4	1.7	1.8	-0.7	0.8
Average weekly red wine intake	0.3	0.5	0.9	-0.4	0.7	-1.0	-0.4	-0.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.7	1.9	1.1	-0.2	1.4	1.2
Mood swings	0.1	0.3	0.8	0.3	-0.9	-0.1	-0.5	0.4
Loneliness, isolation	0.8	1.1	2.4	0.9	-1.6	0.8	1.2	0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.2	0.5	-0.4	-0.7	0.1
Ever had bowel cancer screening	0.6	0.6	1.2	-0.6	0.6	-1.1	-0.4	-1.1
Diabetes diagnosed by doctor	0.7	1.1	1.9	-1.3	0.2	-1.4	-0.6	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.5	1.2	-0.9	-0.3	0.6	0.8
Friendships satisfaction	0.8	1.0	3.2	-0.7	-1.1	1.8	0.3	-0.1
Qualifications: nursing, teaching	0.4	0.7	2.1	0.2	0.9	1.5	0.6	-0.1
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.4	-0.9	-0.6	0.3	-0.1
Eye problems/disorders: Cataract	1.4	1.6	2.5	1.5	-1.5	0.9	0.1	1.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.9	1.1	0.8	-0.0	-1.7	0.4
Medication for cholesterol	0.9	1.3	1.8	1.1	1.3	0.4	1.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.8	0.9	-0.5	-1.9	0.7	0.9
Back pain experienced in last month	0.7	1.0	3.1	0.9	0.1	-1.8	-0.9	0.4
Mineral and other dietary supplements	0.3	0.4	0.6	0.5	0.7	0.5	0.8	0.6
Breast cancer (self-reported)	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.3	0.2
Asthma (self-reported)	0.7	1.4	3.4	1.4	1.0	0.8	0.2	1.9
Osteoporosis (self-reported)	0.7	0.9	3.1	-0.8	0.5	-1.8	-0.1	-0.7
Osteoarthritis (self-reported)	2.9	3.8	8.1	2.9	1.8	0.6	1.8	2.0
Medication: Aspirin	0.2	0.3	0.4	-0.3	-0.7	-0.7	-0.6	0.1
Medication: Gliclazide	1.5	1.7	3.8	0.9	0.6	0.4	1.9	2.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	-1.3	0.1	-0.2	0.5	-0.5
Smoking status: Current	0.5	0.7	1.1	-0.8	0.9	0.3	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	13.0	0.7	-3.6	0.1	1.8	0.4
Whole body water mass	0.6	3.4	6.9	-2.4	-2.6	-1.2	0.0	-1.7
Leg predicted mass (right)	0.6	3.0	6.7	-2.3	-2.6	-0.7	-0.1	-1.6
Arm fat mass (left)	0.1	0.6	1.1	0.6	1.0	1.1	-0.7	0.1
Number of self-reported non-cancer illnesses	0.8	1.5	3.3	1.8	0.6	-1.4	0.1	1.3
Average weekly champagne plus white wine intake	0.7	0.9	1.5	1.0	1.2	1.1	0.4	1.0
Miserableness	0.6	1.1	3.4	0.6	-1.8	0.5	0.8	1.0
Guilty feelings	0.5	0.7	1.3	1.1	1.0	-0.5	0.5	1.0
Wears glasses or contact lenses	0.6	0.7	1.1	-1.1	0.6	1.0	0.5	-0.9
Ever taken oral contraceptive pill	1.0	1.1	2.0	-1.1	-1.2	0.7	-0.8	-1.4
Hearing aid user	0.5	0.5	1.0	-0.9	-1.0	-0.2	-0.6	-0.7
Mother’s age at death	0.2	0.3	0.6	0.2	-0.8	-0.6	-0.7	0.0
Financial situation satisfaction	0.5	0.6	1.0	-0.3	0.5	-0.9	-0.9	-1.0
Tinnitus: Yes, now most or all of the time	1.5	1.7	6.0	-0.4	-1.1	-1.0	-2.4	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.3	0.5	0.5	0.3	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.7	0.3	1.3	0.3	0.5	0.5
Medication: Blood pressure	0.4	0.7	1.6	-0.7	0.2	0.6	-1.1	-1.3
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.3	1.8	-0.7	-0.4	0.8	1.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	1.1	0.3	-0.4	-0.6	0.6
High cholesterol (Self-reported)	1.0	1.9	3.6	-1.6	-1.0	-0.2	-1.4	-1.9
Medication: Bendroflumethiazide	0.6	0.8	3.7	0.1	-0.1	0.7	-1.9	-0.3
Medication: Paracetamol	0.4	0.7	2.2	0.6	-1.5	0.8	0.1	0.4
Medication: Lisinopril	1.8	2.3	4.3	-1.9	-2.1	1.1	-1.2	-1.1
Medication: Atorvastatin	0.3	0.4	1.1	0.2	-0.8	1.0	-0.3	0.2
Illnesses of father: High blood pressure	1.8	2.3	9.4	-0.6	0.1	3.1	1.1	-0.5
Alcohol drinker status: Never	0.1	0.2	0.4	0.0	-0.5	0.1	-0.4	-0.6
Ever smoked	0.3	0.5	0.9	0.9	0.7	-0.7	0.4	0.6
Basal metabolic rate	0.4	2.1	4.1	-1.8	-2.0	-1.1	-0.1	-1.4
Leg fat percentage (left)	0.8	2.7	5.3	2.2	2.3	1.3	-0.1	1.3
Arm fat-free mass (left)	0.3	1.7	4.4	-1.4	-2.1	-0.9	-0.0	-1.1
Number of operations (self-reported)	0.5	0.7	1.3	1.2	0.5	-1.0	0.9	0.5
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.6	-0.2	-0.6	0.9	0.2
Irritability	0.6	1.0	3.9	-0.2	-2.0	-0.6	-0.4	0.7
Risk taking	1.1	1.6	3.7	0.4	-1.7	-1.9	-0.3	1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.2	-0.6	0.2	1.1	-0.2	-0.2
Fractured/broken bones in last 5 years	0.7	0.9	4.1	-0.5	0.0	-2.0	-0.4	-0.1
Age started oral contraceptive pill	0.8	1.0	2.0	-1.1	-0.9	-0.1	-1.4	-0.9
Diastolic blood pressure, automated reading	0.5	1.6	2.3	-1.5	-0.5	1.4	1.2	-1.4
Ever depressed for a whole week	0.9	1.1	2.0	1.4	-0.3	-0.5	1.1	1.4
Unable to work because of sickness or disability	2.3	2.9	4.9	2.2	1.2	-1.6	1.7	1.6
Commuting to job workplace: Cycle	2.8	3.3	11.8	1.1	0.3	1.1	3.4	1.5
Myopia	1.6	2.3	9.9	0.9	3.1	-0.9	0.3	0.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.0	1.4	1.0	0.2	2.0	1.9
Cholesterol lowering medication	0.7	1.1	1.9	-1.4	0.3	-0.8	-1.1	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.8	-0.5	0.5	-0.5	-1.3	-1.0
Pain experienced in last month	1.4	2.4	6.3	-2.5	0.1	1.3	-0.3	-1.9
Supplements: Calcium	1.4	1.5	3.1	-1.0	1.8	-0.9	-1.5	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	-1.0	-0.5	0.2	-0.6	0.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.3	-0.5	1.5	1.1	-0.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.3	1.0	1.8	-0.9	0.3	0.4
Heart disease (siblings)	0.5	0.7	1.8	-0.4	-1.3	-0.4	-1.1	-0.1
Alcohol drinker status: Previous	2.1	2.4	4.6	-1.1	1.1	-0.8	-2.1	-2.2
Pack years of smoking	0.1	0.2	0.5	-0.7	0.5	-0.2	0.0	-0.4
Impedance of whole body	0.4	1.9	3.6	0.9	1.9	-1.9	-1.2	-0.5
Leg fat mass (left)	0.2	0.6	1.2	0.7	0.9	1.1	-0.6	0.2
Arm predicted mass (left)	0.3	1.7	4.2	-1.4	-2.1	-1.1	-0.1	-1.1