Hub : Genes

LINC00854

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0840	0.0470	2.5e-03	0.048	NA	0.027	NA	0.035	1.2e-03	NA	1.2e-02	NA	5.0e-03
2	GTEx	Artery Coronary	0.0990	0.0530	6.2e-03	0.090	NA	0.039	NA	0.070	6.1e-04	NA	1.9e-02	NA	2.3e-03
3	GTEx	Artery Tibial	0.0817	0.0303	1.5e-06	0.048	NA	0.074	NA	0.061	1.3e-04	NA	2.0e-06	NA	1.5e-05
4	GTEx	Cells EBV-transformed lymphocytes	0.2810	0.0810	3.1e-07	0.259	NA	0.265	NA	0.240	5.2e-09	NA	3.4e-09	NA	2.2e-08
5	GTEx	Esophagus Muscularis	0.0630	0.0290	1.1e-03	0.058	NA	0.049	NA	0.048	2.1e-04	NA	6.2e-04	NA	7.0e-04
6	GTEx	Heart Atrial Appendage	0.0670	0.0340	5.8e-03	-0.006	NA	-0.006	NA	-0.004	7.2e-01	NA	1.0e+00	NA	5.0e-01
7	GTEx	Lung	0.0565	0.0281	8.2e-04	0.024	NA	0.013	NA	0.016	5.5e-03	NA	3.3e-02	NA	1.8e-02
8	GTEx	Nerve Tibial	0.0644	0.0268	1.1e-04	0.078	NA	0.039	NA	0.053	3.8e-06	NA	8.7e-04	NA	1.2e-04
9	GTEx	Prostate	0.1600	0.0780	3.7e-03	0.018	NA	0.025	NA	-0.005	1.1e-01	NA	7.8e-02	NA	4.4e-01
10	GTEx	Skin Not Sun Exposed Suprapubic	0.0440	0.0230	9.1e-03	0.019	NA	0.005	NA	0.009	2.9e-02	NA	1.7e-01	NA	9.4e-02
11	GTEx	Testis	0.3930	0.0690	0.0e+00	0.577	NA	0.567	NA	0.582	8.9e-31	NA	5.0e-30	NA	3.8e-31

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.4	1.5	-0.6	-0.3	-1.1	0.1	-0.2	1.2	-0.7	-0.5	-0.0	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.7	3.6	-1.5	-1.3	-1.9	1.2	-1.2	1.0	-1.3	-1.5	-0.4	-1.1	-1.3
Depressed Affect (Nagel 2018)	0.1	0.2	1.6	-0.2	-0.2	-0.1	-0.3	-0.3	0.2	-0.1	-0.2	1.2	-0.2	-0.3
Depression (Nagel 2018)	0.4	0.7	2.6	-1.0	-0.7	-0.4	0.4	-0.8	1.6	-1.1	-0.4	-0.1	-0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.1	1.0	1.1	0.6	-1.5	0.9	-0.1	0.6	1.2	-0.1	1.2	1.2
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-0.6	-0.9	-1.3	0.6	-0.7	-0.6	-1.0	-1.0	0.6	-0.7	-1.0
Schizophrenia (2018)	0.8	1.6	2.5	-1.5	-1.4	-1.6	1.5	-1.3	0.2	-1.1	-1.5	-0.5	-1.2	-1.3
Schizophrenia vs Biploar Disorder	1.7	2.3	4.9	-1.3	-1.3	-1.5	1.7	-1.3	-2.2	-1.1	-1.3	-2.2	-1.1	-1.2
Worry (Nagel 2018)	1.2	2.6	5.7	-1.4	-1.8	-2.4	2.0	-1.3	-0.6	-1.5	-1.8	-0.0	-1.7	-1.6
Alzheimer’s Disease (in mother)	0.2	0.2	1.1	-0.2	-0.2	0.3	0.6	0.0	-1.0	0.2	-0.1	1.0	-0.3	-0.0
Alzheimer’s Disease (in father)	0.1	0.1	0.8	-0.0	0.0	0.6	0.9	-0.4	0.2	0.1	0.0	-0.0	0.3	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	1.0	0.1	0.0	0.6	0.8	-0.1	0.2	0.1	0.2	1.0	0.2	0.2
Crohns Disease (2017)	1.5	3.3	7.7	1.6	1.6	1.0	-0.8	2.1	1.8	1.9	2.1	2.8	1.8	1.6
Irritable Bowel Disease (IBD)	1.0	2.3	5.9	1.3	1.4	0.5	-0.1	1.9	0.9	1.7	2.0	2.4	1.5	1.3
Ulcerative Colitis (UC)	0.3	0.6	2.1	0.6	0.8	-0.1	0.6	1.0	-0.1	0.9	1.4	0.7	0.8	0.7
Major Depression (MDD)	0.5	0.6	1.1	-0.8	-1.0	-0.7	0.8	-0.8	-0.0	-0.6	-1.0	0.4	-0.8	-0.8
Reaction Time	0.3	0.5	4.4	0.0	0.1	0.2	-0.6	-0.0	2.1	-0.8	0.1	0.2	-0.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.2	1.3	1.4	1.4	-1.1	1.1	0.1	1.1	1.5	0.5	1.5	1.4
Breast Cancer	0.3	0.7	1.9	1.1	1.0	0.3	-0.7	0.9	-0.2	0.7	1.0	0.4	1.4	1.1
Ovarian Cancer	1.0	1.3	2.7	-1.1	-1.2	-0.6	1.2	-1.4	-0.1	-1.6	-1.1	-1.4	-1.1	-1.1
Prostate Cancer	0.7	1.0	3.8	0.8	0.8	0.3	-0.6	1.0	-0.8	1.2	0.8	-2.0	0.9	0.8
Age at First Birth	0.3	0.4	1.5	-0.4	-0.3	-1.2	-0.5	0.0	-0.8	-0.3	-0.4	-1.1	-0.5	-0.3
Bipolar Disorder (2011)	0.9	0.8	3.0	-0.9	-0.8	-1.7	1.1	-0.6	0.6	-0.9	-0.9	-0.0	-0.7	-0.9
Body Mass Index (BMI) (2010)	2.4	3.3	6.0	1.8	1.8	2.5	-1.5	1.9	-0.7	2.3	1.9	1.2	1.8	1.9
Coronary Artery Disease (CAD)	1.2	1.5	5.7	-1.2	-1.1	-0.3	1.2	-1.3	-2.4	-0.9	-1.1	-0.4	-1.1	-1.1
Crohns Disease (2012)	0.7	1.1	1.4	1.0	1.1	1.0	-0.7	1.2	0.9	1.1	1.0	1.1	1.2	1.1
Mean Putamen Volume	0.3	0.3	0.8	-0.6	-0.6	-0.1	0.2	-0.7	-0.9	-0.2	-0.6	-0.6	-0.6	-0.6
Fasting Glucose	1.5	1.7	3.3	-1.6	-1.8	-1.2	1.7	-1.2	-0.4	-1.3	-0.3	0.4	-1.7	-1.6
HbA1C	5.5	6.1	9.2	-2.9	-2.6	-1.8	2.5	-3.0	0.8	-2.8	-2.6	-2.2	-2.4	-2.7
HDL Cholesterol	1.0	1.7	3.4	1.4	1.1	1.0	-1.7	1.5	-0.7	1.8	1.2	1.0	1.2	1.3
LDL Cholesterol	0.4	0.7	3.0	0.8	0.9	0.6	-1.7	0.7	-0.2	0.8	0.8	-0.1	0.7	0.7
Lupus	2.8	4.2	6.9	-1.9	-2.0	-2.6	1.3	-1.9	-2.1	-2.1	-1.9	-2.6	-2.0	-1.9
Neuroticism (2016)	0.5	0.7	1.1	-0.7	-1.0	-1.1	0.9	-0.9	-0.5	-0.5	-1.1	-0.6	-0.9	-0.9
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.7	-0.6	-0.0	0.8	-0.7	-0.2	-0.3	-0.6	0.1	-0.7	-0.6
Rheumatoid Arthritis	0.3	0.5	2.8	-0.5	-0.6	-0.0	0.5	-0.6	-1.7	-0.2	-0.5	-0.4	-0.7	-0.5
Schizophrenia (2014)	2.8	6.3	11.2	-2.8	-2.6	-3.3	2.6	-2.5	-0.1	-2.2	-2.8	-2.3	-2.4	-2.6
Triglycerides	2.7	4.5	9.2	-2.2	-2.1	-1.9	2.0	-2.2	0.6	-3.0	-2.3	-1.7	-2.1	-2.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.5	-1.7	-1.6	-1.4	1.9	-1.6	-1.2	-1.6	-1.7	-0.2	-1.6	-1.7
Ulcerative Colitis	0.2	0.3	1.6	0.2	0.3	-0.5	0.1	0.4	-1.3	0.2	0.3	0.9	0.1	0.2
Blood Eosinophil Count	2.1	16.4	24.2	4.6	4.5	4.1	-2.8	4.9	-2.1	4.9	4.4	1.6	4.4	4.5
Blood Platelet Count	0.0	0.2	0.8	-0.2	-0.1	0.1	-0.9	0.0	0.3	-0.5	-0.4	0.8	-0.3	-0.2
Blood Red Count	0.1	0.5	4.3	-0.3	-0.4	-0.6	-0.3	-0.4	-2.1	-0.3	-0.4	-0.1	-0.5	-0.4
Blood White Count	4.2	31.2	49.0	6.1	6.2	7.0	-5.1	5.5	0.0	6.5	6.1	2.8	6.1	6.2
Heel T-Score	3.3	26.3	38.7	-5.7	-5.8	-4.2	6.2	-5.2	0.2	-5.9	-5.8	-2.8	-5.6	-5.7
BMI	1.7	10.0	24.6	3.1	3.2	5.0	-2.1	2.8	-2.9	3.2	3.2	2.2	3.1	3.1
Height	0.2	2.9	11.3	1.1	1.0	0.5	3.4	0.9	-2.4	1.5	1.3	-2.4	0.9	1.1
Waist Hip Ratio (WHR)	0.2	1.1	2.9	-0.8	-0.8	-1.1	-1.5	-0.4	1.0	-1.7	-0.9	-0.6	-0.9	-0.9
Systolic Blood Pressure	0.8	4.1	12.0	-1.9	-2.0	-3.5	1.9	-1.8	-0.9	-1.7	-1.9	-1.8	-2.1	-2.0
Smoking Status	1.6	3.8	5.3	-2.0	-2.0	-1.9	2.2	-2.3	0.9	-2.3	-2.0	-1.5	-2.0	-2.0
Allergy or Eczema	0.1	0.2	1.3	0.1	0.1	-0.4	-0.0	0.7	0.6	0.2	0.1	1.1	0.1	0.1
Cardiovascular Disease	0.5	1.8	2.5	-1.2	-1.3	-1.4	1.2	-1.3	-1.1	-1.5	-1.2	-1.6	-1.5	-1.2
Hypothyroidism (self reported)	0.6	1.3	3.2	-1.2	-1.2	-1.4	1.8	-0.8	-0.9	-0.4	-1.2	-0.6	-1.2	-1.1
Respiratory disease	0.3	0.8	3.0	0.5	0.5	0.6	-0.4	0.6	1.6	0.5	0.5	1.7	0.6	0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.2	5.2	-0.9	-0.7	-0.5	0.8	-0.8	-2.3	-0.9	-0.9	-1.4	-0.7	-0.8
Lung FEV1/FVC ratio	0.8	3.9	6.4	2.2	2.0	1.4	-2.5	2.4	-1.3	2.0	2.2	-0.7	1.9	2.3
Lung FVC	0.3	1.7	8.6	-0.8	-0.9	-1.4	1.4	-1.3	2.9	-1.0	-0.9	-0.5	-0.8	-0.9
Neuroticism	0.3	0.7	1.8	-0.9	-0.8	-1.4	0.7	-0.8	-0.6	-0.7	-0.9	0.9	-0.7	-0.9
Chronotype (morning person)	0.3	0.7	3.7	-0.5	-0.4	-0.4	-0.1	-0.3	-1.9	-0.4	-0.4	-1.7	-0.3	-0.4
Hair Pigment	0.0	0.8	4.3	-0.4	-0.2	0.2	-0.0	-0.3	-2.1	0.0	-0.3	-2.0	-0.4	-0.4
Tanning	0.2	2.1	2.8	-1.4	-1.6	-1.7	1.2	-1.5	1.0	-1.5	-1.5	-1.3	-1.7	-1.6
Hand grip strength (left)	4.3	11.3	16.3	-3.4	-3.6	-3.3	4.0	-3.6	-2.1	-3.0	-3.5	-3.1	-3.7	-3.4
Number of treatments/medications taken	0.7	1.3	1.9	-1.2	-1.2	-1.2	0.9	-1.2	-0.6	-1.2	-1.3	-0.2	-1.4	-1.3
Average weekly spirits intake	0.7	0.9	1.6	-1.0	-1.0	-0.8	0.8	-1.1	0.0	-1.3	-0.9	-1.2	-0.8	-1.0
Sensitivity / hurt feelings	0.6	1.1	3.1	-0.9	-1.1	-0.7	0.5	-0.8	-1.8	-1.1	-1.1	-0.6	-1.1	-1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	4.7	-0.1	0.0	-0.1	-0.4	-0.1	2.2	-0.3	-0.1	0.8	0.1	-0.1
Hearing difficulty/problems: Yes	0.4	0.7	3.7	0.3	0.5	0.5	-0.5	0.6	1.9	0.6	0.5	1.2	0.5	0.4
Relative age of first facial hair	0.8	1.6	3.3	-1.1	-1.2	-1.0	1.4	-1.3	-0.4	-1.5	-1.2	-1.8	-1.2	-1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	-1.0	-1.0	-1.4	0.9	-0.7	0.2	-1.3	-1.0	-0.6	-0.9	-1.0
Ever used hormone-replacement therapy (HRT)	4.9	6.3	8.9	2.7	2.9	2.9	-2.4	2.8	0.1	2.5	2.8	1.0	3.0	2.8
Ever had hysterectomy (womb removed)	1.7	1.9	2.4	1.3	1.3	1.4	-1.3	1.5	1.4	1.3	1.4	1.4	1.4	1.4
Systolic blood pressure, automated reading	0.0	0.1	0.3	0.2	0.2	-0.5	0.3	0.2	0.2	0.3	0.2	-0.6	0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	-0.9	-0.7	-0.4	1.1	-0.9	0.9	-1.1	-0.8	-1.4	-0.9	-0.8
Angina	0.3	0.5	2.3	-0.4	-0.4	-0.6	0.3	-0.2	-1.1	-0.2	-0.5	-1.5	-0.4	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.3	0.1	0.3	0.5	0.5	0.2	-0.2	0.4	0.1	0.2	0.5	0.1
Vitamin and mineral supplements	3.5	4.8	5.6	2.3	2.3	2.4	-2.3	2.0	2.1	2.0	2.3	1.6	2.3	2.2
Supplements: Zinc	4.1	4.4	6.1	-2.4	-2.3	-2.4	1.8	-2.3	-1.0	-1.8	-2.2	-1.6	-2.5	-2.4
Medication: Co-codamol	0.2	0.2	2.0	0.1	0.2	-0.2	0.4	0.3	-1.4	0.1	0.2	0.0	0.1	0.1
Medication: Metformin	1.1	1.6	5.0	-1.3	-0.9	-0.4	1.7	-1.0	-2.2	-0.9	-1.1	-1.4	-0.8	-1.2
Diabetes (father)	0.1	0.1	1.2	-0.1	-0.3	0.1	0.3	-0.2	-1.1	-0.0	-0.1	-0.1	-0.2	-0.2
Diabetes (mother)	0.2	0.2	0.6	0.1	0.3	0.6	-0.7	0.5	0.3	0.8	0.3	-0.3	0.6	0.2
Severe depression (siblings)	4.9	5.4	7.7	-2.5	-2.6	-2.5	1.9	-2.6	-0.1	-2.8	-2.5	-1.8	-2.6	-2.5
Pack years adult smoking proportion	0.3	0.5	3.1	-0.3	-0.4	-0.4	0.3	-0.6	-1.8	-0.4	-0.4	-0.7	-0.5	-0.4
Impedance of leg (right)	1.1	5.2	11.3	-2.4	-2.4	-3.4	1.7	-2.2	0.8	-2.3	-2.5	-1.9	-2.3	-2.4
Leg fat-free mass (left)	0.8	4.5	11.0	2.1	2.2	3.3	-0.3	1.9	-2.2	2.2	2.3	0.7	2.2	2.3
Trunk fat percentage	1.6	6.3	18.7	2.3	2.7	4.3	-1.1	2.1	-0.6	2.4	2.6	2.3	2.8	2.5
Hand grip strength (right)	6.0	16.2	22.8	-4.2	-4.4	-3.9	4.8	-4.4	-2.3	-3.7	-4.2	-3.4	-4.4	-4.2
Townsend deprivation index at recruitment	0.6	0.9	2.6	0.8	0.9	1.1	-1.0	0.7	0.2	0.8	0.7	1.6	1.1	0.7
Current tobacco smoking	0.5	0.8	6.8	-0.2	-0.2	-0.3	0.7	-0.6	2.6	-0.4	-0.2	0.7	-0.3	-0.3
Average weekly fortified wine intake	5.2	6.1	9.2	-2.6	-2.5	-3.0	2.5	-2.3	0.4	-2.8	-2.6	-2.1	-2.7	-2.6
Maternal smoking around birth	0.1	0.1	0.7	-0.1	-0.1	0.4	0.6	-0.0	0.2	0.2	-0.0	0.9	-0.1	0.0
Fed-up feelings	0.2	0.3	1.7	0.3	0.2	0.5	-0.7	0.1	0.7	0.2	0.2	1.3	0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.3	0.8	1.0	1.5	-0.7	0.8	0.8	0.6	0.9	1.5	1.2	0.9
Relative age voice broke	3.0	4.6	6.3	-2.2	-2.2	-2.0	2.4	-2.3	-0.6	-2.5	-2.3	-2.0	-2.2	-2.3
Taking other prescription medications	0.4	0.6	1.1	-1.0	-0.9	-0.8	0.8	-0.7	-0.3	-0.6	-1.0	0.3	-1.0	-1.0
Age when periods started (menarche)	0.7	1.6	7.0	-0.8	-1.0	-1.4	0.5	-0.6	-2.6	-0.6	-0.6	-1.8	-1.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	4.4	0.2	0.2	0.4	-0.8	0.5	2.1	-0.1	0.2	0.1	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.0	-0.9	-1.2	-0.4	1.7	-0.5	-0.1	-1.1	-1.0	0.3	-1.2	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.4	-0.4	-0.8	0.7	-0.3	0.6	-0.3	-0.3	0.2	-0.4	-0.4
Qualifications: CSEs or equivalent	1.8	2.4	3.6	-1.7	-1.9	-1.0	1.4	-1.6	-1.9	-1.5	-1.7	-0.3	-1.8	-1.7
Serious illness, injury or assault to yourself	0.6	0.7	2.1	0.7	0.7	1.4	-0.7	0.9	-1.1	0.7	0.8	-0.0	0.8	0.8
High blood pressure	0.2	0.4	0.9	0.7	0.8	0.2	-0.9	0.8	0.6	0.3	0.9	-0.1	0.6	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.3	-0.4	-0.6	0.2	0.2	0.0	-0.3	-0.4	0.8	-0.3	-0.3
Multivitamins +/- minerals	0.2	0.3	1.6	-0.3	-0.2	-0.3	0.2	0.1	-1.3	0.2	-0.2	-0.9	-0.3	-0.2
Stomach or abdominal pain in last month	0.3	0.4	1.1	-0.4	-0.5	-0.7	0.6	-0.4	1.0	-0.5	-0.4	0.6	-0.5	-0.5
Supplements: Glucosamine	1.4	1.9	2.6	1.4	1.4	1.2	-1.1	1.6	-1.2	1.6	1.5	0.9	1.4	1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-0.8	-0.9	-0.0	0.9	-0.8	-0.6	-1.0	-0.9	-0.2	-0.6	-0.8
Medication: Atenolol	0.1	0.1	0.8	0.2	0.0	0.2	0.1	0.1	-0.9	0.0	0.1	0.3	-0.1	0.2
Medication: Levothyroxine sodium	0.1	0.2	1.1	-0.0	-0.0	0.3	0.8	0.1	-1.0	0.7	-0.0	-0.6	-0.1	-0.0
Sitting height	1.0	7.2	11.4	3.1	3.0	1.7	-0.7	3.4	-2.1	3.2	3.2	0.6	3.1	3.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.3	-0.2	-0.6	0.1	-0.1	-0.3	-0.0	-0.1
High blood pressure (mother)	1.0	1.4	8.6	0.7	0.8	0.3	-1.0	0.7	2.9	0.5	0.6	1.5	0.8	0.6
Body mass index (BMI)	1.5	6.4	19.8	2.4	2.6	4.5	-1.7	2.1	-1.1	2.3	2.5	2.3	2.5	2.5
Impedance of leg (left)	1.1	5.3	12.1	-2.4	-2.5	-3.5	1.7	-2.2	0.7	-2.2	-2.5	-1.6	-2.4	-2.4
Leg predicted mass (left)	0.9	4.5	11.1	2.1	2.2	3.3	-0.3	1.9	-2.2	2.2	2.3	0.7	2.2	2.3
Trunk fat mass	1.5	6.6	19.0	2.5	2.8	4.4	-0.9	2.2	-1.1	2.5	2.7	1.9	2.8	2.6
Waist circumference	1.7	6.1	15.3	2.5	2.7	3.9	-2.1	2.4	-0.5	2.2	2.6	1.8	2.6	2.5
Number of incorrect matches in round	1.2	2.0	6.8	-1.0	-1.1	-1.3	1.5	-0.8	-2.6	-0.4	-1.2	-1.8	-1.1	-1.2
Past tobacco smoking	0.8	1.5	3.6	1.1	1.1	0.7	-1.1	1.4	-1.4	1.9	1.2	0.6	1.1	1.3
Alcohol usually taken with meals	0.2	0.3	1.2	-0.2	-0.1	-0.8	-0.5	-0.0	-1.1	0.2	-0.1	-1.1	0.1	-0.1
Nervous feelings	0.2	0.4	0.8	0.8	0.7	0.4	-0.2	0.8	-0.1	0.9	0.8	0.4	0.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	4.9	-1.9	-1.8	-2.0	2.2	-1.7	0.2	-1.9	-1.9	-0.8	-1.8	-2.0
Hearing difficulty/problems with background noise	0.9	1.4	5.8	0.8	0.9	0.8	-0.7	1.1	2.4	0.8	0.9	1.8	1.0	0.8
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	-0.9	-1.1	-0.8	0.5	-0.8	-0.5	-0.5	-0.9	-0.4	-1.0	-0.8
Had menopause	11.7	14.6	19.8	4.3	4.2	3.6	-3.0	4.5	1.7	3.9	4.3	3.0	4.3	4.3
Had other major operations	0.1	0.1	0.9	-0.2	-0.2	-0.2	0.1	-0.0	0.9	-0.7	-0.0	-0.0	-0.2	-0.2
Forced vital capacity (FVC)	0.3	1.1	4.0	-0.7	-1.0	-1.4	2.0	-1.0	0.1	-0.7	-0.8	-1.0	-1.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	3.7	-1.2	-1.4	-0.9	1.9	-0.9	-0.3	-1.4	-1.3	-0.2	-1.4	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.3	-0.1	-0.0	0.3	0.4	-0.3	1.1	-0.1	-0.1	1.1	0.0	-0.1
Qualifications: None of the above	0.6	1.3	5.5	1.0	0.9	1.2	-0.3	0.8	2.3	0.6	0.9	1.6	0.9	0.8
Financial difficulties in last 2 years	0.4	0.5	1.0	0.7	0.7	0.9	-0.9	0.4	0.3	-0.1	0.6	1.0	0.8	0.6
Mouth/teeth dental problems	0.2	0.3	2.2	0.2	-0.1	-0.3	-0.8	0.3	-0.7	0.2	0.0	-1.5	-0.2	0.0
Heart attack	1.2	1.6	3.3	-1.4	-1.4	-0.6	0.8	-1.1	-0.9	-1.1	-1.4	-1.8	-1.3	-1.4
Allergy	0.1	0.2	0.5	0.4	0.4	0.4	-0.3	-0.0	-0.3	0.5	0.4	-0.7	0.3	0.4
Pain all over the body in last month	0.1	0.1	0.5	0.3	0.3	0.5	-0.1	0.2	-0.2	0.5	0.2	0.7	0.3	0.3
Diabetes (self-reported)	0.3	0.5	2.4	-0.6	-0.3	0.0	0.6	-0.5	-1.6	-0.7	-0.4	-1.1	-0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.7	1.4	1.2	0.6	-0.9	1.7	0.4	1.6	1.2	1.4	1.1	1.4
Medication: Ramipril	3.2	4.1	6.0	2.2	2.1	2.5	-2.0	2.2	0.4	2.1	2.4	0.9	2.1	2.3
Medication: Simvastatin	0.1	0.1	1.2	-0.0	0.1	0.2	0.0	0.1	-1.1	0.0	0.2	-0.0	0.1	0.1
Fluid intelligence score	0.0	0.1	0.2	0.2	0.3	0.2	-0.1	0.1	0.3	0.1	0.3	0.5	0.2	0.3
Illnesses of siblings	0.1	0.2	0.7	-0.2	-0.3	-0.8	0.2	-0.1	0.8	0.1	-0.3	-0.3	-0.5	-0.2
Neuroticism score	0.1	0.2	1.2	0.1	-0.1	-0.4	-0.3	0.0	-0.6	0.1	-0.1	1.1	-0.1	-0.1
Weight	1.2	5.9	15.8	2.4	2.6	4.0	-0.6	2.2	-1.9	2.4	2.6	1.3	2.6	2.6
Impedance of arm (right)	0.3	1.3	2.2	-1.1	-1.1	-1.4	1.5	-1.1	1.2	-1.2	-1.1	-0.0	-1.0	-1.0
Arm fat percentage (right)	1.4	5.6	20.6	2.1	2.4	4.5	-1.3	1.8	-0.3	2.0	2.3	2.4	2.4	2.2
Trunk fat-free mass	0.3	1.6	4.1	1.3	1.3	1.6	0.4	1.0	-2.0	1.3	1.4	-0.5	1.2	1.3
Hip circumference	1.3	5.8	14.9	2.4	2.6	3.9	-0.5	2.1	-1.3	2.6	2.6	1.8	2.6	2.5
Time employed in main current job	0.7	0.8	1.2	1.1	0.9	0.4	-1.1	1.0	0.6	0.6	1.1	0.7	0.8	1.0
Alcohol intake versus 10 years previously	0.5	0.8	1.3	-1.1	-0.9	-0.3	0.9	-1.0	0.2	-1.0	-1.0	-0.8	-0.9	-1.0
Father’s age at death	0.3	0.4	2.8	-0.1	-0.0	-1.0	-0.2	-0.1	0.4	-0.1	0.1	-1.7	0.1	0.0
Worrier / anxious feelings	1.8	3.4	6.4	-2.0	-2.0	-2.5	1.7	-1.9	-0.4	-1.7	-2.0	-1.1	-1.9	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.1	-1.1	-1.2	-0.8	0.7	-1.4	1.5	-1.3	-1.2	0.0	-1.2	-1.2
Falls in the last year	1.4	1.8	5.2	-1.3	-1.3	-0.8	2.3	-1.5	-0.6	-1.2	-1.4	-1.1	-1.3	-1.4
Hair/balding pattern: Pattern 3	0.6	0.9	2.7	0.9	0.9	0.6	-1.2	0.8	1.6	0.5	1.0	-0.6	0.8	0.8
Number of live births	0.2	0.3	2.2	0.1	0.1	0.9	-0.1	0.1	1.5	0.0	-0.0	0.7	0.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.1	-0.7	-1.0	-1.2	1.6	-1.1	-1.0	-0.7	-0.8	-1.8	-1.0	-0.7
Pulse rate	0.6	1.0	1.3	-1.1	-0.9	-1.0	0.9	-1.1	1.0	-1.1	-1.0	-0.4	-0.9	-1.0
Happiness	1.6	2.0	2.9	1.4	1.6	1.3	-1.7	1.4	1.3	1.0	1.5	1.1	1.5	1.5
Noisy workplace	0.3	0.4	2.8	-0.1	0.0	0.0	0.6	0.1	1.0	0.2	0.1	1.7	0.0	-0.0
Qualifications: A levels/AS levels or equivalent	2.3	5.1	8.3	2.4	2.3	2.0	-2.9	2.5	-0.5	2.8	2.5	1.2	2.3	2.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.5	-0.1	0.0	-0.7	0.5	-0.2	1.2	-0.4	-0.2	0.7	0.0	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	-0.5	-0.6	0.1	1.2	-0.8	0.9	-0.9	-0.5	0.7	-0.7	-0.6
Asthma	0.1	0.2	1.2	0.1	0.1	0.0	0.3	0.2	1.0	0.2	0.2	1.1	0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	-0.6	-0.7	-1.0	0.9	-0.7	-0.8	-0.4	-0.6	-1.2	-0.9	-0.6
Medication: Cholesterol lowering	1.0	1.5	2.2	1.2	1.3	1.3	-1.1	1.5	-1.0	1.2	1.3	0.7	1.3	1.3
Depression (self-reported)	0.3	0.4	3.7	-0.3	-0.1	0.1	-0.1	-0.4	1.9	-0.1	-0.2	0.3	-0.2	-0.3
Medication: Lansoprazole	0.8	0.9	1.2	-1.1	-1.1	-0.7	0.6	-1.0	-0.4	-0.9	-1.1	-1.0	-1.1	-1.0
Prospective memory result	0.6	0.7	1.2	-1.0	-0.9	-1.1	0.6	-0.9	-0.4	-0.9	-1.0	-0.1	-0.9	-1.0
Lung cancer (father)	0.2	0.2	0.6	0.4	0.3	0.7	-0.1	0.3	0.8	0.5	0.4	0.7	0.1	0.3
Illnesses of mother	1.3	1.6	7.4	-1.0	-1.0	-0.9	0.7	-0.9	-2.7	-0.9	-1.1	-1.3	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.8	0.2	-0.1	-0.2	0.6	-0.1	-0.4	0.1	0.1	-0.9	-0.0	0.2
Pulse wave Arterial Stiffness index	0.9	1.1	3.8	0.8	0.7	0.8	-1.3	0.9	2.0	0.6	0.9	0.9	0.9	0.9
Impedance of arm (left)	0.1	0.6	2.7	-0.5	-0.5	-1.1	1.0	-0.4	1.6	-0.5	-0.5	0.3	-0.4	-0.4
Arm fat mass (right)	1.3	5.4	18.3	2.2	2.4	4.3	-0.9	1.9	-1.4	2.1	2.4	1.9	2.4	2.3
Trunk predicted mass	0.3	1.7	4.4	1.3	1.3	1.6	0.4	1.1	-2.1	1.4	1.4	-0.5	1.2	1.3
Standing height	0.2	1.7	7.9	0.0	-0.0	-0.8	2.8	0.0	-2.2	0.1	0.2	-2.2	0.1	0.2
Length of working week for main job	0.1	0.1	0.7	0.1	0.3	0.4	0.3	-0.3	0.8	-0.5	0.1	-0.0	0.4	0.1
Exposure to tobacco smoke at home	0.4	0.5	0.8	-0.9	-0.8	-0.2	0.4	-0.8	0.7	-0.9	-0.8	0.4	-0.7	-0.9
Breastfed as a baby	0.3	0.4	2.3	-0.2	-0.3	-0.9	0.3	-0.2	1.5	-0.6	-0.2	0.3	-0.4	-0.2
Tense / ‘highly strung’	3.9	6.5	9.6	-2.6	-2.7	-2.8	3.1	-2.7	-0.9	-2.6	-2.8	-1.4	-2.8	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	-0.3	-0.1	-0.0	0.0	-0.5	0.7	-0.8	-0.4	-0.2	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.6	1.4	4.0	1.2	1.2	1.1	-0.3	0.9	2.0	0.8	1.2	1.2	1.4	1.2
Birth weight of first child	0.1	0.2	1.4	0.0	-0.2	-0.2	-0.1	0.0	1.2	-0.0	0.0	0.2	-0.5	0.0
Peak expiratory flow (PEF)	0.8	1.9	7.3	-0.9	-1.1	-1.2	1.0	-1.0	-2.1	-1.0	-1.0	-2.7	-1.2	-0.8
Pulse wave reflection index	0.5	0.6	2.1	0.8	0.5	0.7	-1.4	0.8	0.4	0.8	0.8	0.7	0.5	0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.6	-0.5	-0.6	-0.3	0.9	-0.6	1.6	-0.8	-0.5	1.3	-0.6	-0.6
Loud music exposure frequency	0.6	0.6	1.4	-0.8	-1.0	-0.8	0.9	-0.6	-0.2	-0.6	-0.9	0.4	-1.2	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.6	0.6	0.4	0.6	-1.3	0.5	0.5	0.7	0.6	0.5	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.4	0.5	0.2	-0.4	0.3	0.3	0.4	0.4	0.2	0.5	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.5	0.3	0.2	0.7	0.0	0.2	-0.4	0.1	0.2	-0.4	0.3	0.2
Medication: Paracetamol	2.4	4.0	5.7	-2.2	-2.2	-1.9	1.9	-2.2	-1.2	-1.9	-2.2	-1.0	-2.4	-2.2
Headache pain in last month	3.6	6.2	11.7	-2.7	-2.7	-3.4	1.9	-2.7	-1.4	-2.2	-2.7	-1.0	-2.7	-2.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.3	-1.3	-1.4	-1.4	1.1	-1.5	0.4	-1.2	-1.5	-0.8	-1.3	-1.4
Glaucoma (self-reported)	0.4	0.4	1.6	0.6	0.7	-0.0	-1.3	0.9	-0.4	0.4	0.6	0.2	0.7	0.6
Gout (self-reported)	5.0	6.9	9.1	2.9	2.7	2.6	-2.8	3.0	-0.5	2.7	3.0	2.3	2.6	2.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.9	-1.1	-1.2	-1.0	2.2	-0.8	-1.3	-0.1	-1.2	-0.8	-1.1	-1.1
Medication: Amlodipine	3.1	4.4	5.7	2.3	2.4	2.4	-1.8	2.2	1.2	1.7	2.2	1.9	2.3	2.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.4	-0.8	-0.8	-0.7	1.2	-0.7	-0.0	-0.8	-0.8	-0.5	-0.8	-0.8
Birth weight	1.8	3.8	5.1	2.1	2.1	1.7	-1.9	1.8	1.9	1.3	2.1	1.9	2.2	2.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.5	-0.3	-0.4	0.5	-0.6	0.3	-0.1	-0.3	-0.5	-0.3	-0.4
High blood pressure (siblings)	0.1	0.1	0.4	-0.1	0.1	0.2	-0.0	-0.1	-0.6	-0.2	-0.0	0.4	0.3	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	1.4	-0.2	-0.4	-0.7	1.2	-0.4	0.1	-0.2	-0.2	-0.6	-0.3	-0.2
Body fat percentage	1.7	6.6	19.7	2.4	2.8	4.4	-1.5	2.2	-0.4	2.4	2.6	2.5	2.8	2.5
Leg fat percentage (right)	1.8	6.4	17.7	2.4	2.7	4.2	-2.1	2.2	0.1	2.3	2.5	2.2	2.7	2.5
Arm fat-free mass (right)	0.4	2.3	4.5	1.5	1.6	2.0	0.1	1.3	-2.1	1.6	1.6	-0.1	1.6	1.6
Exposure to tobacco smoke outside home	0.4	0.5	1.1	-0.6	-0.7	-0.9	0.8	-0.8	-0.4	-0.8	-0.6	-1.0	-0.6	-0.7
Comparative body size at age 10	0.3	0.8	2.0	0.9	0.8	1.4	-1.3	0.5	0.9	0.5	0.8	0.2	0.9	0.9
Number of full brothers	0.6	0.7	1.8	0.8	0.8	0.9	-1.3	0.6	0.4	0.7	0.9	0.8	0.9	0.8
Worry too long after embarrassment	0.1	0.2	1.4	0.1	-0.1	-1.2	-0.5	0.2	0.6	-0.4	-0.0	-0.3	-0.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.1	1.0	1.2	1.6	-0.8	1.0	2.0	0.7	0.9	2.0	1.2	0.9
Wheeze or whistling in the chest in last year	0.7	1.3	3.7	-1.2	-1.2	-0.6	1.9	-1.4	0.6	-0.8	-1.2	0.7	-1.2	-1.2
Number of children fathered	0.6	0.7	2.0	-0.9	-1.0	-0.1	1.4	-0.9	-0.3	-0.6	-0.9	-0.6	-1.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-0.6	-0.4	-0.8	0.9	-0.8	-1.1	-1.1	-0.5	-1.4	-0.2	-0.5
Age at first live birth	0.2	0.3	2.4	-0.2	-0.2	-0.1	-0.4	-0.2	-1.5	-0.3	-0.0	-0.8	-0.2	-0.1
Pulse wave peak to peak time	0.7	0.8	4.3	-0.5	-0.4	-0.5	1.2	-0.5	-2.1	-0.3	-0.5	-0.9	-0.6	-0.6
Health satisfaction	0.1	0.1	0.7	-0.1	0.1	0.0	0.8	-0.0	-0.1	-0.5	-0.1	0.5	-0.1	-0.1
Shortness of breath walking on level ground	0.6	0.7	4.5	-0.1	-0.3	0.3	0.6	-0.1	1.4	-0.6	-0.2	2.1	-0.3	-0.3
Qualifications: College or University degree	0.1	0.4	1.7	0.4	0.5	0.1	-0.3	0.6	-1.3	0.8	0.4	-0.3	0.5	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.0	0.7	0.7	0.5	-0.5	0.7	-0.1	1.0	0.6	0.9	0.6	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	0.6	0.9	1.4	-0.1	0.4	-0.8	0.7	0.7	0.6	1.0	0.7
Emphysema/chronic bronchitis	0.5	0.6	1.1	-0.9	-0.9	-0.3	1.0	-1.0	0.3	-0.9	-0.8	0.5	-0.6	-0.8
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	0.8	0.8	1.5	-1.0	0.7	1.6	0.6	0.9	1.0	1.2	0.9
Neck or shoulder pain in last month	4.5	6.4	8.7	-3.0	-2.8	-2.5	2.6	-2.6	0.1	-2.8	-2.9	-1.6	-2.5	-2.9
Medication: Blood pressure	0.5	0.8	1.3	1.0	1.1	1.0	-0.8	1.1	-0.4	0.8	1.1	0.7	1.0	1.0
Angina (self-reported)	0.4	0.5	2.5	-0.4	-0.5	-0.6	0.4	-0.3	-1.1	-0.2	-0.6	-1.6	-0.4	-0.5
Migraine (self-reported)	6.9	8.6	12.1	-3.2	-3.3	-3.5	2.3	-3.0	-1.4	-3.1	-3.2	-2.1	-3.3	-3.2
Medication: Ibuprofen	0.4	0.5	1.5	-0.4	-0.4	-1.0	0.7	-0.5	-0.6	-0.5	-0.5	-1.2	-0.6	-0.4
Medication: Allopurinol	8.6	11.5	15.7	3.6	3.5	3.4	-3.6	4.0	-0.3	3.3	3.8	3.1	3.4	3.7
Medication: Omeprazole	0.3	0.3	0.7	0.5	0.8	0.6	-0.5	0.6	-0.6	0.2	0.5	0.6	0.8	0.5
Medication: Seretide 50 evohaler	0.2	0.2	1.7	0.2	0.2	0.3	0.3	0.0	1.3	-0.2	-0.0	-0.2	0.2	0.1
Mean time to correctly identify matches	0.7	1.3	8.9	0.7	0.8	0.6	-1.0	0.6	3.0	-0.3	0.7	0.8	0.9	0.6
Heart disease (mother)	0.2	0.3	2.6	0.0	0.1	0.3	-0.4	0.2	1.6	-0.1	0.1	0.3	0.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.4	0.5	0.6	0.5	-1.1	0.8	1.8	0.8	0.5	1.5	0.4	0.6
Whole body fat mass	1.5	6.3	18.7	2.4	2.7	4.3	-1.1	2.1	-1.2	2.4	2.6	2.0	2.7	2.5
Leg fat mass (right)	1.6	6.2	18.2	2.4	2.7	4.3	-1.5	2.2	-1.0	2.4	2.6	2.0	2.6	2.5
Arm predicted mass (right)	0.4	2.1	4.9	1.4	1.5	2.0	0.1	1.2	-2.2	1.5	1.5	0.0	1.5	1.5
Pulse rate, automated reading	0.7	2.2	3.3	-1.7	-1.5	-1.0	1.8	-1.8	0.1	-1.7	-1.5	-1.2	-1.6	-1.6
Alcohol intake frequency.	0.2	0.4	1.6	-0.4	-0.2	1.2	-0.0	-0.6	1.3	-0.3	-0.4	0.3	-0.3	-0.3
Comparative height size at age 10	0.1	0.8	3.2	0.5	0.4	-0.1	1.5	0.5	-1.8	0.9	0.5	-1.1	0.4	0.5
Number of full sisters	2.4	3.0	8.2	1.6	1.4	2.9	-1.2	1.3	0.7	1.9	1.6	2.5	1.2	1.5
Suffer from ‘nerves’	1.3	2.0	3.2	-1.4	-1.6	-1.5	1.8	-1.3	-1.2	-1.3	-1.6	-0.6	-1.5	-1.5
Overall health rating	0.6	1.3	4.9	-0.7	-0.7	-0.5	1.6	-0.7	2.2	-1.2	-0.8	1.1	-0.6	-0.8
Chest pain or discomfort	3.3	4.8	7.3	-2.1	-2.3	-2.1	2.7	-2.0	2.6	-2.2	-2.2	-0.1	-2.4	-2.2
Had major operations	0.1	0.1	0.5	-0.1	-0.2	-0.2	0.4	-0.4	0.7	0.0	-0.3	0.1	-0.4	-0.3
Age at last live birth	0.5	0.8	1.6	-0.8	-0.8	-0.3	0.3	-0.9	-1.3	-1.1	-0.7	-1.2	-0.9	-0.7
Family relationship satisfaction	3.7	4.5	6.3	2.4	2.5	2.4	-2.0	2.1	0.5	1.7	2.4	1.5	2.5	2.4
Leg pain on walking	1.0	1.3	1.9	-1.2	-1.3	-1.4	1.0	-1.1	-0.2	-1.2	-1.3	0.0	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.5	-0.5	-0.2	0.2	-0.5	-0.4	-0.5	-0.4	-0.3	-0.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.7	-0.5	-0.2	-0.4	-0.2	-0.2	1.3	-0.4	-0.3	0.3	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.8	1.5	1.5	1.4	-1.3	1.5	-0.1	2.0	1.5	0.5	1.5	1.5
Medication: Aspirin	0.1	0.1	0.5	0.1	0.2	0.5	0.4	0.3	-0.5	0.7	0.2	0.3	0.1	0.2
Supplements: Vitamin C	6.9	8.1	12.2	-3.2	-2.9	-3.5	2.4	-2.9	-1.5	-3.1	-3.2	-2.0	-3.0	-3.1
Knee pain experienced in last month	0.3	0.5	2.9	0.5	0.4	1.7	-0.1	0.2	0.1	0.5	0.4	1.1	0.2	0.4
Hypertension (Self-reported)	0.1	0.4	0.9	0.6	0.7	0.1	-1.0	0.7	0.5	0.1	0.9	-0.2	0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.9	0.5	0.6	0.2	-0.9	0.6	0.3	0.5	0.4	0.3	0.5	0.4
Illnesses of father: Heart disease	3.2	4.4	6.8	-2.1	-2.2	-2.1	2.6	-2.1	-2.3	-1.8	-2.2	-0.9	-2.2	-2.2
Illnesses of siblings: Diabetes	0.5	0.7	1.1	-0.9	-0.9	-0.4	0.9	-1.1	-0.4	-0.9	-1.0	-0.3	-0.8	-1.0
Smoking status: Previous	1.0	1.5	3.3	-1.2	-1.1	-0.9	1.0	-1.3	-0.5	-1.8	-1.3	-1.5	-1.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.5	1.6	1.5	1.0	-0.5	1.4	0.0	1.4	1.5	0.9	1.6	1.6
Whole body fat-free mass	0.4	2.5	5.1	1.6	1.6	2.3	0.2	1.3	-2.2	1.6	1.7	-0.1	1.6	1.6
Leg fat-free mass (right)	0.8	4.2	9.7	2.1	2.1	3.1	-0.3	1.8	-2.2	2.1	2.2	1.0	2.1	2.2
Arm fat percentage (left)	1.8	7.0	22.1	2.5	2.8	4.7	-1.6	2.2	-0.2	2.4	2.6	2.7	2.7	2.6
Average weekly red wine intake	4.1	6.1	7.8	-2.5	-2.6	-2.8	2.4	-2.6	-0.4	-2.3	-2.5	-2.8	-2.6	-2.6
Handedness (chirality/laterality): Left-handed	5.4	6.5	9.1	-2.8	-2.9	-2.4	2.5	-2.7	-0.4	-2.6	-2.8	-2.1	-3.0	-2.9
Mood swings	0.1	0.2	0.4	-0.4	-0.4	-0.6	0.0	-0.5	-0.0	-0.3	-0.3	0.6	-0.6	-0.4
Loneliness, isolation	2.0	2.8	5.6	1.7	1.7	1.3	-2.4	1.7	-1.1	2.0	1.7	0.8	1.8	1.6
Long-standing illness, disability or infirmity	1.3	1.9	3.6	-1.5	-1.4	-1.8	1.5	-1.3	1.0	-1.9	-1.4	-0.2	-1.4	-1.4
Ever had bowel cancer screening	0.1	0.1	0.6	-0.3	-0.1	-0.8	0.3	-0.0	-0.2	-0.2	-0.3	-0.3	-0.1	-0.4
Diabetes diagnosed by doctor	0.5	0.8	1.7	-0.9	-0.7	-0.2	1.1	-0.9	-1.3	-1.0	-0.8	-1.1	-0.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.1	-0.4	-0.4	0.1	0.8	-0.5	1.0	-0.4	-0.5	1.0	-0.5	-0.5
Friendships satisfaction	0.7	0.8	2.5	0.9	1.0	1.0	-0.5	0.9	-1.6	0.6	0.8	0.3	0.9	0.8
Qualifications: nursing, teaching	3.3	5.1	6.4	-2.4	-2.3	-2.5	2.0	-2.5	-0.3	-2.2	-2.4	-2.5	-2.4	-2.3
Commuting to job workplace: Walk	0.7	0.7	2.1	0.8	0.8	0.8	-0.8	0.7	0.0	1.1	0.8	1.5	0.8	0.8
Eye problems/disorders: Cataract	0.9	1.0	1.5	-1.1	-1.0	-1.0	1.2	-0.8	-0.9	-1.2	-0.9	-0.9	-1.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	4.3	0.2	0.5	0.5	0.1	0.2	0.7	0.3	0.3	2.1	0.7	0.3
Medication for cholesterol	0.2	0.4	0.7	-0.5	-0.7	-0.9	0.5	-0.5	0.1	-0.6	-0.7	-0.7	-0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.8	-0.1	-0.1	-0.9	-0.1	-0.3	-0.2	-0.3	-0.2	-0.9	-0.2	-0.3
Back pain experienced in last month	0.8	1.2	4.8	0.9	0.7	0.7	-0.0	1.0	2.2	0.5	0.8	1.9	0.6	0.8
Mineral and other dietary supplements	0.3	0.4	1.3	0.6	0.7	0.8	-0.5	0.6	1.1	0.4	0.5	0.7	0.6	0.5
Breast cancer (self-reported)	0.5	0.6	1.2	0.8	0.8	0.8	-0.1	0.8	1.1	0.7	0.8	0.5	0.7	0.7
Asthma (self-reported)	0.1	0.2	1.4	0.1	0.2	-0.1	0.1	0.4	0.6	0.4	0.2	1.2	0.3	0.2
Osteoporosis (self-reported)	0.5	0.7	1.9	0.7	1.1	0.4	-1.4	0.7	0.5	0.7	0.8	0.6	1.0	0.7
Osteoarthritis (self-reported)	0.8	1.0	2.1	1.0	1.1	1.2	-0.6	1.3	0.0	0.7	1.0	1.5	0.9	0.9
Medication: Aspirin	0.2	0.2	0.8	-0.6	-0.4	-0.1	0.9	-0.4	-0.5	-0.0	-0.5	-0.2	-0.6	-0.6
Medication: Gliclazide	0.6	0.7	4.8	0.2	0.5	0.9	0.0	0.6	-2.2	0.4	0.4	-0.4	0.6	0.3
Illnesses of father: None of the above (group 1)	4.1	5.1	8.7	2.4	2.5	1.7	-3.0	2.3	2.0	1.9	2.4	1.2	2.4	2.4
Smoking status: Current	0.6	0.9	6.1	-0.5	-0.6	-0.7	0.9	-0.9	2.5	-0.7	-0.5	0.3	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	0.3	0.5	0.5	-0.9	0.0	0.3	0.4	0.3	-0.5	0.6	0.4
Whole body water mass	0.4	2.1	4.9	1.4	1.4	2.0	0.4	1.1	-2.2	1.4	1.5	-0.2	1.4	1.4
Leg predicted mass (right)	0.8	4.5	10.3	2.2	2.2	3.2	-0.4	1.9	-2.1	2.2	2.3	1.0	2.2	2.3
Arm fat mass (left)	1.4	5.9	19.1	2.3	2.6	4.4	-1.0	2.0	-1.1	2.2	2.5	2.0	2.6	2.4
Number of self-reported non-cancer illnesses	0.4	0.8	2.0	-0.9	-1.0	-1.4	0.7	-0.5	0.6	-1.0	-0.9	-0.0	-1.0	-1.0
Average weekly champagne plus white wine intake	0.2	0.3	1.8	0.1	0.2	-0.1	-0.9	0.4	-1.4	0.4	0.3	-0.3	0.0	0.2
Miserableness	1.6	2.8	9.5	1.6	1.4	1.7	-1.3	1.4	0.9	1.6	1.3	3.1	1.6	1.4
Guilty feelings	0.5	0.7	2.8	0.7	0.7	0.9	-0.6	0.5	-0.5	0.7	0.6	1.7	0.7	0.7
Wears glasses or contact lenses	0.2	0.3	0.5	0.5	0.6	0.2	-0.7	0.7	-0.2	0.4	0.6	0.5	0.5	0.5
Ever taken oral contraceptive pill	0.6	0.7	2.5	0.7	0.7	0.4	-0.8	0.9	-1.6	0.9	0.7	0.6	0.6	0.7
Hearing aid user	1.4	1.5	2.3	1.3	1.4	0.8	-1.5	1.4	0.6	1.1	1.4	0.9	1.5	1.3
Mother’s age at death	0.2	0.2	1.7	0.3	0.3	0.1	-0.1	0.4	1.3	0.4	0.3	-0.3	0.2	0.3
Financial situation satisfaction	0.2	0.3	0.6	-0.2	-0.2	0.6	0.8	-0.6	0.8	-0.5	-0.2	0.5	-0.4	-0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.8	-0.8	-0.6	0.7	-0.8	1.1	-1.1	-0.8	0.2	-1.0	-0.9
Commuting to job workplace: Public transport	0.2	0.2	0.8	0.3	0.1	-0.4	-0.0	0.1	-0.9	-0.2	0.2	-0.9	0.0	0.2
Eye problems/disorders: Glaucoma	0.9	1.1	2.7	1.0	1.1	1.0	-1.6	1.2	-0.5	0.8	1.0	0.3	1.2	1.1
Medication: Blood pressure	0.1	0.2	0.7	0.2	0.3	0.0	-0.6	0.4	0.9	-0.3	0.4	0.4	0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	-1.0	-1.1	-0.6	1.5	-0.8	-0.6	-1.2	-1.1	-0.0	-1.2	-1.1
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.1	-1.4	-1.6	-1.6	1.4	-1.5	-1.1	-1.4	-1.4	-1.8	-1.5	-1.2
High cholesterol (Self-reported)	0.1	0.2	0.8	-0.4	-0.1	-0.9	-0.2	-0.2	0.6	-0.6	-0.2	-0.6	-0.2	-0.3
Medication: Bendroflumethiazide	0.6	0.9	2.1	-1.0	-0.9	-1.0	0.6	-0.9	-1.0	-1.5	-0.8	-0.7	-1.1	-0.9
Medication: Paracetamol	2.5	3.9	5.6	-2.0	-2.1	-1.9	1.9	-2.1	-1.7	-1.8	-2.1	-1.1	-2.4	-2.1
Medication: Lisinopril	1.7	2.2	4.3	-1.5	-1.5	-1.9	1.3	-1.2	-0.3	-2.1	-1.5	-1.5	-1.5	-1.4
Medication: Atorvastatin	3.3	4.0	5.7	2.2	2.2	1.6	-2.4	2.2	1.6	1.8	2.2	1.1	2.3	2.1
Illnesses of father: High blood pressure	0.1	0.2	1.7	-0.0	-0.1	0.1	0.2	0.1	-1.3	-0.2	-0.1	0.0	-0.0	-0.0
Alcohol drinker status: Never	1.6	2.0	3.5	1.3	1.3	1.5	-1.3	1.3	1.9	1.0	1.2	1.8	1.3	1.2
Ever smoked	0.9	1.6	7.5	-0.8	-1.0	-0.8	1.0	-1.1	2.7	-1.6	-0.9	-0.2	-1.0	-1.0
Basal metabolic rate	0.6	3.3	7.6	1.8	1.9	2.8	-0.0	1.6	-2.2	1.9	2.0	0.3	1.9	1.9
Leg fat percentage (left)	1.8	6.5	17.1	2.4	2.7	4.1	-2.1	2.2	-0.1	2.4	2.6	2.4	2.7	2.5
Arm fat-free mass (left)	0.4	1.8	5.0	1.2	1.3	2.0	0.4	1.0	-2.2	1.3	1.3	-0.1	1.3	1.3
Number of operations (self-reported)	0.4	0.6	2.3	0.7	0.6	1.0	-0.8	0.5	1.5	0.7	0.7	0.6	0.6	0.6
Average weekly beer plus cider intake	1.0	1.5	2.5	-1.3	-1.4	-0.2	1.3	-1.4	0.6	-1.4	-1.3	-1.0	-1.6	-1.4
Irritability	0.1	0.1	0.8	0.1	0.0	0.0	-0.5	0.0	-0.7	0.3	0.0	0.9	0.1	0.0
Risk taking	0.1	0.1	0.4	0.2	0.3	0.6	-0.3	-0.1	-0.4	0.0	0.2	0.1	0.2	0.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	0.8	0.7	-0.1	-0.7	0.9	0.1	0.8	0.8	0.1	0.7	0.8
Fractured/broken bones in last 5 years	5.1	6.6	8.8	2.9	2.8	2.3	-2.8	2.7	-1.5	3.0	2.8	1.3	2.8	2.8
Age started oral contraceptive pill	1.3	1.6	2.5	1.4	1.5	0.7	-1.4	1.4	1.2	1.2	1.6	0.2	1.3	1.4
Diastolic blood pressure, automated reading	2.5	7.6	15.3	3.0	2.9	3.9	-3.0	2.5	-1.2	2.7	3.1	1.0	2.9	3.0
Ever depressed for a whole week	2.5	3.1	4.4	-2.0	-1.9	-2.1	1.9	-1.7	-0.3	-1.8	-2.0	-0.8	-1.9	-2.0
Unable to work because of sickness or disability	0.4	0.5	3.2	-0.0	0.1	1.1	0.2	-0.1	1.8	-0.2	-0.0	0.9	0.1	-0.0
Commuting to job workplace: Cycle	0.4	0.4	0.8	0.8	0.7	0.9	-0.6	0.7	0.2	0.7	0.7	-0.1	0.6	0.8
Myopia	0.3	0.4	1.8	0.2	0.2	-0.5	-0.8	0.1	-1.3	-0.0	0.2	-1.3	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.2	-0.9	-0.9	-0.6	1.1	-1.1	-0.2	-0.6	-1.1	0.3	-0.7	-0.9
Cholesterol lowering medication	0.1	0.1	0.4	0.2	0.4	0.3	-0.7	0.4	0.5	-0.1	0.3	0.2	0.4	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	1.5	-0.2	0.1	-0.1	0.1	0.0	-1.2	-0.4	-0.2	-0.1	0.1	-0.2
Pain experienced in last month	1.2	1.9	3.4	1.4	1.6	1.2	-1.3	1.4	1.2	1.3	1.5	0.8	1.9	1.5
Supplements: Calcium	0.4	0.4	0.9	0.6	0.7	0.5	-0.6	0.5	-0.2	0.8	0.6	-0.0	0.9	0.7
Basal cell carcinoma (self-reported)	1.5	1.8	2.8	1.5	1.5	0.9	-1.7	1.7	-0.3	1.5	1.5	0.4	1.6	1.5
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.2	-1.6	-1.5	-0.7	1.0	-1.3	-0.6	-1.2	-1.5	-1.8	-1.5	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	0.3	0.2	0.6	0.0	0.3	-0.5	0.2	0.2	-0.3	0.3	0.2
Heart disease (siblings)	0.5	0.6	1.1	-0.8	-0.8	-0.7	0.7	-0.7	-1.1	-0.9	-0.8	-0.8	-0.6	-0.9
Alcohol drinker status: Previous	1.0	1.1	1.5	-1.2	-1.0	-0.9	1.1	-1.2	1.0	-1.2	-1.2	-0.0	-1.1	-1.2
Pack years of smoking	0.1	0.2	1.4	-0.1	-0.2	-0.2	0.3	-0.4	-1.2	-0.2	-0.2	-0.4	-0.3	-0.2
Impedance of whole body	0.3	1.4	3.3	-1.2	-1.2	-1.8	1.3	-1.0	1.3	-1.1	-1.2	-0.2	-1.0	-1.1
Leg fat mass (left)	1.5	6.0	17.4	2.3	2.6	4.2	-1.4	2.1	-1.2	2.4	2.5	2.0	2.5	2.5
Arm predicted mass (left)	0.3	1.8	5.5	1.2	1.3	1.8	0.3	1.0	-2.3	1.2	1.3	-0.3	1.3	1.3