Hub : Genes

LINC00910

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.067 0.038 6.2e-03 0.029 NA 0.004 NA 0.019 9.2e-03 NA 1.8e-01 NA 3.1e-02
2 GTEx Skin Sun Exposed Lower leg 0.105 0.048 2.7e-03 -0.003 NA 0.017 NA 0.002 7.0e-01 NA 1.3e-02 NA 1.9e-01
3 GTEx Testis 0.599 0.068 1.5e-13 0.464 NA 0.455 NA 0.473 7.6e-23 NA 2.8e-22 NA 2.1e-23

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 1.5 -0.4 0.5 1.2
Bipolar Disorder or Schizophrenia 0.2 0.6 1.0 -1.0 0.2 0.9
Depressed Affect (Nagel 2018) 0.0 0.1 0.2 -0.0 -0.1 -0.4
Depression (Nagel 2018) 1.2 1.8 3.7 -1.3 0.3 1.9
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.5 0.3 -1.2 1.0
Neuroticism (Nagel 2018) 0.2 0.4 0.6 -0.8 -0.6 0.5
Schizophrenia (2018) 0.2 0.3 0.9 -1.0 -0.1 0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 -0.9 -0.7 0.2
Worry (Nagel 2018) 0.4 0.9 2.1 -1.4 -0.6 0.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 0.2 0.6 -0.7
Alzheimer’s Disease (in father) 0.5 0.5 1.0 0.5 1.0 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.2 0.6 -0.2
Crohns Disease (2017) 1.8 4.0 5.2 2.3 1.6 -2.1
Irritable Bowel Disease (IBD) 1.5 3.5 4.4 2.0 1.3 -2.1
Ulcerative Colitis (UC) 0.4 0.8 1.1 1.1 0.4 -1.1
Major Depression (MDD) 0.2 0.2 0.4 -0.4 0.4 -0.6
Reaction Time 1.8 3.4 6.9 -1.3 -1.3 2.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.8 0.8 -1.4 0.1
Breast Cancer 0.4 1.1 2.9 0.4 1.7 0.4
Ovarian Cancer 2.9 3.8 6.4 -1.7 -1.4 2.5
Prostate Cancer 1.3 1.8 3.0 1.5 0.3 -1.7
Age at First Birth 0.0 0.1 0.2 -0.2 -0.4 0.1
Bipolar Disorder (2011) 0.5 0.5 0.8 -0.8 0.4 0.9
Body Mass Index (BMI) (2010) 3.2 4.4 6.7 2.4 0.9 -2.6
Coronary Artery Disease (CAD) 0.4 0.4 0.9 -0.6 -1.0 -0.0
Crohns Disease (2012) 0.8 1.2 2.0 1.4 0.9 -0.9
Mean Putamen Volume 0.1 0.1 0.4 -0.1 -0.2 -0.6
Fasting Glucose 0.5 0.6 1.3 -1.2 -0.6 0.3
HbA1C 6.7 7.5 7.8 -2.8 -2.8 2.6
HDL Cholesterol 3.1 5.2 8.7 2.2 1.3 -3.0
LDL Cholesterol 0.3 0.4 0.5 0.7 0.6 -0.7
Lupus 2.6 3.9 5.4 -2.3 -1.6 2.0
Neuroticism (2016) 0.2 0.3 0.7 -0.3 0.3 -0.8
Primary Biliary Cirrhosis 0.7 1.0 2.4 -0.1 -1.5 -0.7
Rheumatoid Arthritis 0.1 0.2 0.5 -0.2 -0.1 -0.7
Schizophrenia (2014) 0.6 1.4 3.7 -1.9 -0.2 0.7
Triglycerides 6.5 10.6 17.6 -3.2 -2.0 4.2
Type 2 Diabetes (T2D) (2012) 1.2 1.3 2.4 -1.5 -0.6 1.1
Ulcerative Colitis 0.1 0.1 0.3 0.1 -0.5 -0.1
Blood Eosinophil Count 1.9 14.8 22.2 4.7 1.5 -4.5
Blood Platelet Count 0.0 0.4 0.8 -0.5 0.4 0.9
Blood Red Count 0.0 0.4 1.1 -0.1 -1.1 -0.0
Blood White Count 3.2 24.0 41.3 6.4 0.9 -5.5
Heel T-Score 3.2 25.5 36.0 -6.0 -4.7 4.2
BMI 0.8 4.9 9.4 3.1 0.1 -2.3
Height 0.3 5.8 12.0 1.4 -3.5 -1.9
Waist Hip Ratio (WHR) 1.3 5.8 10.0 -2.0 -1.8 3.2
Systolic Blood Pressure 0.3 1.4 2.6 -1.6 -1.2 0.5
Smoking Status 2.2 5.2 5.5 -2.2 -2.2 2.3
Allergy or Eczema 0.2 0.5 0.9 0.3 0.9 -0.7
Cardiovascular Disease 0.9 2.9 3.7 -1.9 -1.2 1.9
Hypothyroidism (self reported) 0.4 0.9 2.0 -0.1 0.9 -1.4
Respiratory disease 0.7 1.6 4.3 0.4 2.1 -0.6
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.1 -0.9 -1.8 1.1
Lung FEV1/FVC ratio 0.2 0.8 1.7 1.3 -0.3 -0.8
Lung FVC 0.1 0.7 1.2 -0.8 0.3 1.1
Neuroticism 0.1 0.2 0.5 -0.7 -0.5 0.2
Chronotype (morning person) 0.1 0.3 0.6 -0.5 -0.8 0.5
Hair Pigment 0.0 0.7 1.1 0.6 -0.8 -1.1
Tanning 0.1 1.7 2.7 -1.6 -1.1 1.1
Hand grip strength (left) 1.3 3.5 6.8 -2.6 -1.6 1.0
Number of treatments/medications taken 0.3 0.6 1.2 -1.1 -0.5 0.7
Average weekly spirits intake 1.0 1.3 2.0 -1.3 0.4 1.4
Sensitivity / hurt feelings 1.8 3.1 7.1 -1.2 -2.7 0.9
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.2 -0.1 1.5 0.3
Hearing difficulty/problems: Yes 0.5 0.7 1.0 0.8 1.0 -0.7
Relative age of first facial hair 1.2 2.5 3.1 -1.7 -1.2 1.8
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.0 -1.3 -0.7 1.4
Ever used hormone-replacement therapy (HRT) 2.2 2.8 6.6 2.6 0.9 -1.0
Ever had hysterectomy (womb removed) 0.8 0.9 1.3 1.2 1.1 -0.5
Systolic blood pressure, automated reading 0.1 0.3 0.7 0.5 -0.1 -0.8
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 4.7 -1.3 -2.2 1.8
Angina 0.0 0.1 0.1 -0.2 0.1 -0.4
Medication for hormone replacement therapy 0.5 0.5 0.8 0.7 -0.6 -0.9
Vitamin and mineral supplements 1.5 2.1 3.8 2.0 1.4 -0.6
Supplements: Zinc 0.7 0.8 2.3 -1.5 0.0 -0.0
Medication: Co-codamol 0.0 0.0 0.1 0.2 0.1 -0.1
Medication: Metformin 1.8 2.6 7.1 -0.6 -2.7 0.4
Diabetes (father) 0.1 0.1 0.2 -0.0 -0.4 -0.3
Diabetes (mother) 1.4 1.8 3.8 1.2 0.3 -1.9
Severe depression (siblings) 5.1 5.6 8.2 -2.9 -1.2 2.7
Pack years adult smoking proportion 0.2 0.3 0.5 -0.6 0.7 0.2
Impedance of leg (right) 0.4 1.9 4.3 -2.1 -0.7 0.9
Leg fat-free mass (left) 0.4 2.0 4.1 2.0 -0.6 -1.2
Trunk fat percentage 0.6 2.3 5.7 2.4 0.2 -1.1
Hand grip strength (right) 1.7 4.8 10.6 -3.2 -1.3 1.4
Townsend deprivation index at recruitment 0.3 0.4 0.6 0.8 0.7 -0.4
Current tobacco smoking 0.3 0.5 1.0 -0.7 0.4 1.0
Average weekly fortified wine intake 4.2 4.9 8.0 -2.8 -0.7 2.5
Maternal smoking around birth 0.1 0.1 0.4 0.1 0.0 -0.7
Fed-up feelings 0.0 0.0 0.0 0.1 0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 1.8 0.7 1.3 0.0
Relative age voice broke 3.2 4.9 7.0 -2.6 -1.4 2.4
Taking other prescription medications 0.1 0.1 0.1 -0.4 -0.1 -0.3
Age when periods started (menarche) 0.3 0.7 1.2 -0.9 -1.1 0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.6 -0.5 0.2 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 2.3 -1.5 -1.3 1.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.3 0.7 -0.0
Qualifications: CSEs or equivalent 0.8 1.1 2.2 -1.5 -1.0 0.1
Serious illness, injury or assault to yourself 0.3 0.4 0.9 0.5 -0.9 -0.0
High blood pressure 0.4 1.1 1.6 -0.0 -1.3 1.3
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.2 -0.3 0.4 -0.3
Multivitamins +/- minerals 0.5 0.7 1.3 0.1 -0.8 -1.1
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.5 -0.3 0.4
Supplements: Glucosamine 1.3 1.8 2.5 1.6 1.0 -1.3
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.6 -1.1 -0.4 1.3
Medication: Atenolol 0.1 0.1 0.3 -0.1 -0.6 0.1
Medication: Levothyroxine sodium 1.1 1.8 4.5 0.9 0.3 -2.1
Sitting height 0.8 5.3 9.4 3.1 -1.2 -2.3
Chronic bronchitis/emphysema (father) 0.5 0.6 1.4 0.1 -1.2 -0.5
High blood pressure (mother) 0.8 1.1 3.0 0.6 1.7 0.2
Body mass index (BMI) 0.5 2.2 5.4 2.3 0.5 -1.1
Impedance of leg (left) 0.4 1.8 4.2 -2.0 -0.8 0.8
Leg predicted mass (left) 0.4 2.0 4.1 2.0 -0.6 -1.2
Trunk fat mass 0.6 2.6 6.3 2.5 -0.1 -1.2
Waist circumference 0.3 1.3 3.6 1.9 -0.2 -0.3
Number of incorrect matches in round 0.5 0.8 2.5 0.1 -0.2 -1.6
Past tobacco smoking 2.8 5.1 8.4 1.9 1.8 -2.9
Alcohol usually taken with meals 0.3 0.5 0.8 0.3 0.7 -0.9
Nervous feelings 0.2 0.3 0.4 0.7 0.2 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.9 -1.7 -0.5 1.1
Hearing difficulty/problems with background noise 0.2 0.4 0.5 0.7 0.6 -0.4
Hair/balding pattern: Pattern 2 0.2 0.2 0.5 -0.7 -0.2 -0.3
Had menopause 5.4 6.8 13.8 3.7 1.6 -1.9
Had other major operations 1.7 2.1 3.0 -1.1 -1.5 1.7
Forced vital capacity (FVC) 0.1 0.3 0.6 -0.8 -0.4 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.2 3.0 -1.7 -1.2 1.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 0.1 0.4 -0.1
Qualifications: None of the above 0.1 0.2 0.3 0.4 0.6 0.3
Financial difficulties in last 2 years 0.6 0.9 2.5 -0.3 -0.1 1.6
Mouth/teeth dental problems 0.2 0.3 0.5 0.1 0.5 -0.7
Heart attack 0.4 0.4 1.1 -1.1 -0.4 0.1
Allergy 0.1 0.2 0.4 0.5 -0.6 -0.3
Pain all over the body in last month 0.6 0.7 1.1 0.8 0.5 -1.1
Diabetes (self-reported) 1.4 2.1 4.8 -0.6 -2.2 1.1
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 2.2 1.3 1.4 -1.5
Medication: Ramipril 1.0 1.2 2.9 1.7 0.3 -0.9
Medication: Simvastatin 0.6 0.9 2.3 0.0 -1.5 0.5
Fluid intelligence score 0.1 0.2 0.5 -0.1 -0.7 0.4
Illnesses of siblings 1.2 1.7 4.0 0.1 2.0 -1.1
Neuroticism score 0.1 0.2 0.5 0.1 -0.4 -0.7
Weight 0.5 2.3 5.2 2.3 -0.8 -1.0
Impedance of arm (right) 0.2 1.0 1.6 -1.3 -0.3 1.1
Arm fat percentage (right) 0.4 1.7 4.5 2.1 0.3 -0.8
Trunk fat-free mass 0.2 1.3 1.6 1.3 -1.2 -0.9
Hip circumference 0.9 3.8 7.0 2.6 0.3 -2.1
Time employed in main current job 0.1 0.1 0.3 0.3 -0.0 0.5
Alcohol intake versus 10 years previously 0.3 0.4 0.7 -0.8 0.0 0.8
Father’s age at death 0.1 0.1 0.2 0.1 -0.5 0.5
Worrier / anxious feelings 0.7 1.4 2.7 -1.6 -1.1 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 2.3 -1.5 0.1 1.1
Falls in the last year 0.3 0.4 0.8 -0.9 -0.6 0.3
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.5 0.1 0.6
Number of live births 0.1 0.2 0.4 0.2 0.6 0.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.0 -0.9 -1.0 0.3
Pulse rate 0.7 1.2 1.5 -0.8 -1.2 1.2
Happiness 0.4 0.5 0.8 0.9 -0.6 0.5
Noisy workplace 0.3 0.3 0.6 0.5 0.4 -0.8
Qualifications: A levels/AS levels or equivalent 2.7 5.9 8.0 2.8 1.5 -2.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.5 -0.1 -0.6 0.7
Mouth/teeth dental problems: Dentures 1.0 1.6 2.2 -1.0 -1.3 1.5
Asthma 0.3 0.6 1.4 0.2 1.2 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.7 -0.4 -0.8 -0.3
Medication: Cholesterol lowering 0.3 0.5 0.8 0.9 -0.7 -0.3
Depression (self-reported) 0.2 0.2 0.4 0.2 0.4 -0.6
Medication: Lansoprazole 0.2 0.3 0.5 -0.7 -0.6 0.0
Prospective memory result 0.3 0.3 0.6 -0.7 0.0 0.6
Lung cancer (father) 0.2 0.2 0.6 0.3 -0.0 -0.8
Illnesses of mother 1.0 1.3 2.6 -1.0 -1.6 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.3 -0.1 -0.5 -0.1
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 0.3 -0.9 0.5
Impedance of arm (left) 0.0 0.2 0.4 -0.6 0.3 0.4
Arm fat mass (right) 0.4 1.6 4.2 2.0 -0.1 -0.8
Trunk predicted mass 0.3 1.4 1.7 1.3 -1.2 -1.0
Standing height 0.3 3.0 8.8 -0.1 -3.0 0.1
Length of working week for main job 1.1 1.2 3.2 -0.5 -0.4 1.8
Exposure to tobacco smoke at home 0.4 0.5 0.8 -0.8 0.0 0.9
Breastfed as a baby 1.3 1.6 2.5 -0.7 -1.6 1.3
Tense / ‘highly strung’ 2.1 3.4 5.7 -2.4 -1.7 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.5 -0.8 -0.5 1.9
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 0.3 -0.2 0.6
Birth weight of first child 0.0 0.1 0.2 -0.4 0.1 0.1
Peak expiratory flow (PEF) 0.7 1.7 2.9 -1.1 -1.7 1.0
Pulse wave reflection index 0.2 0.2 0.3 0.4 0.5 -0.5
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.1 -1.0 -0.6 1.1
Loud music exposure frequency 0.2 0.2 0.2 -0.5 -0.4 -0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.1 0.6 0.6 -1.0
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 0.3 0.2 0.1
Blood clot in the leg (DVT) 0.0 0.1 0.1 0.1 -0.4 0.2
Medication: Paracetamol 0.9 1.4 3.8 -2.0 -0.0 0.7
Headache pain in last month 0.8 1.5 4.2 -2.0 0.3 0.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 0.9 -0.9 1.0 -0.2
Glaucoma (self-reported) 0.2 0.3 0.5 0.3 0.5 0.7
Gout (self-reported) 1.6 2.2 5.0 2.2 -0.0 -1.2
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 5.1 0.3 0.9 -2.3
Medication: Amlodipine 0.6 0.8 2.3 1.5 0.2 0.4
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 -0.7 -0.9 0.2
Birth weight 0.5 1.1 1.6 1.0 -0.9 1.3
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 0.1 0.5 -0.6
High blood pressure (siblings) 0.3 0.5 0.8 -0.1 -0.9 0.8
Forced vital capacity (FVC), Best measure 0.0 0.0 0.1 -0.2 0.1 0.0
Body fat percentage 0.6 2.4 6.0 2.4 0.4 -1.1
Leg fat percentage (right) 0.7 2.4 6.1 2.5 0.5 -1.0
Arm fat-free mass (right) 0.3 1.4 2.3 1.5 -1.0 -1.0
Exposure to tobacco smoke outside home 0.4 0.5 0.9 -1.0 0.3 0.8
Comparative body size at age 10 0.1 0.4 0.9 0.5 1.0 0.2
Number of full brothers 0.5 0.6 1.6 0.3 1.3 0.4
Worry too long after embarrassment 0.4 0.7 1.2 -0.4 -1.1 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.6 0.8 0.3 0.2
Wheeze or whistling in the chest in last year 0.2 0.3 0.5 -0.6 0.1 -0.7
Number of children fathered 0.1 0.1 0.4 -0.6 -0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 2.3 2.7 5.4 -1.2 -1.0 2.3
Age at first live birth 0.9 1.6 4.0 -0.5 -2.0 0.8
Pulse wave peak to peak time 0.5 0.6 1.1 0.1 1.1 -0.8
Health satisfaction 0.6 0.8 1.2 -0.2 -1.1 1.1
Shortness of breath walking on level ground 0.7 0.8 1.4 -0.7 -0.7 1.2
Qualifications: College or University degree 0.3 0.8 1.5 0.9 0.4 -1.2
Eye problems/disorders: None of the above 1.2 1.4 1.8 1.0 1.1 -1.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.9 0.8 -0.9 -0.5
Emphysema/chronic bronchitis 0.4 0.5 0.7 -0.8 -0.4 0.7
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 0.8 0.5 -0.1
Neck or shoulder pain in last month 3.0 4.2 6.4 -2.5 -1.7 1.9
Medication: Blood pressure 0.5 0.9 1.8 0.5 -1.3 0.8
Angina (self-reported) 0.1 0.1 0.2 -0.2 0.1 -0.5
Migraine (self-reported) 4.1 5.1 10.2 -3.2 -1.2 2.0
Medication: Ibuprofen 0.8 0.9 1.5 -0.7 -1.2 0.9
Medication: Allopurinol 2.0 2.7 7.3 2.7 -0.2 -0.8
Medication: Omeprazole 0.3 0.4 0.8 0.4 -0.9 0.3
Medication: Seretide 50 evohaler 0.2 0.2 0.5 -0.1 0.2 0.7
Mean time to correctly identify matches 1.8 3.4 8.2 -0.8 -1.2 2.9
Heart disease (mother) 0.4 0.5 1.2 -0.2 1.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.5 3.0 6.4 1.0 2.5 -1.3
Whole body fat mass 0.6 2.6 6.2 2.5 0.1 -1.3
Leg fat mass (right) 0.6 2.4 5.8 2.4 -0.1 -1.2
Arm predicted mass (right) 0.3 1.5 2.2 1.5 -1.2 -1.0
Pulse rate, automated reading 1.1 3.4 3.9 -1.7 -2.0 1.8
Alcohol intake frequency. 0.2 0.5 1.4 -0.3 1.2 0.1
Comparative height size at age 10 0.5 2.5 3.4 1.0 -1.8 -1.8
Number of full sisters 2.0 2.5 3.9 1.7 0.8 -2.0
Suffer from ‘nerves’ 0.5 0.8 1.6 -1.3 -0.8 0.4
Overall health rating 0.9 1.9 2.7 -1.1 -1.3 1.6
Chest pain or discomfort 1.7 2.4 5.0 -2.2 -0.5 1.4
Had major operations 0.2 0.3 0.5 0.2 -0.7 -0.6
Age at last live birth 2.2 3.2 5.9 -1.3 -2.4 1.4
Family relationship satisfaction 0.6 0.8 2.1 1.5 -0.4 0.3
Leg pain on walking 0.5 0.7 1.5 -1.2 0.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.4 0.6 0.2
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 0.1 -0.2 0.2
Illness, injury, bereavement, stress in last 2 years 3.6 4.4 6.4 2.2 1.4 -2.5
Medication: Aspirin 0.8 1.0 2.3 0.7 -0.3 -1.5
Supplements: Vitamin C 3.7 4.3 8.0 -2.8 -1.1 2.0
Knee pain experienced in last month 0.2 0.3 0.3 0.5 0.5 -0.5
Hypertension (Self-reported) 0.4 1.2 2.3 -0.2 -1.1 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.4 0.7 0.6 -0.5
Illnesses of father: Heart disease 0.9 1.2 3.2 -1.8 -0.7 0.2
Illnesses of siblings: Diabetes 0.6 0.8 1.2 -0.8 -1.1 0.7
Smoking status: Previous 3.1 4.6 6.3 -1.5 -2.5 2.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.2 1.1 -0.4 -0.5
Whole body fat-free mass 0.3 1.5 2.4 1.6 -1.1 -1.0
Leg fat-free mass (right) 0.3 1.9 3.7 1.9 -0.7 -1.2
Arm fat percentage (left) 0.6 2.4 5.9 2.4 0.6 -1.1
Average weekly red wine intake 1.6 2.3 5.0 -2.2 -0.8 1.1
Handedness (chirality/laterality): Left-handed 2.2 2.7 6.0 -2.4 -0.6 1.3
Mood swings 0.3 0.5 1.1 -0.5 -1.1 0.2
Loneliness, isolation 3.6 5.0 6.5 2.3 1.8 -2.6
Long-standing illness, disability or infirmity 2.1 3.2 5.2 -1.9 -1.0 2.3
Ever had bowel cancer screening 0.2 0.2 0.5 0.2 0.7 -0.3
Diabetes diagnosed by doctor 1.9 3.2 6.0 -1.0 -2.4 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.6 -0.2 -1.2 0.0
Friendships satisfaction 0.2 0.2 0.4 0.6 -0.5 -0.2
Qualifications: nursing, teaching 1.1 1.8 3.7 -1.9 -0.2 1.2
Commuting to job workplace: Walk 1.7 1.8 2.8 0.9 1.7 -1.3
Eye problems/disorders: Cataract 1.6 1.9 2.9 -1.1 -1.7 1.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.1 0.6 1.0 -0.2
Medication for cholesterol 0.3 0.5 0.7 -0.7 0.9 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.1 -0.2 -0.1 0.2
Back pain experienced in last month 0.1 0.2 0.3 0.3 -0.6 0.4
Mineral and other dietary supplements 0.1 0.1 0.2 0.4 -0.4 0.1
Breast cancer (self-reported) 0.2 0.3 0.5 0.7 0.3 -0.5
Asthma (self-reported) 0.5 1.0 1.8 0.5 1.3 -1.0
Osteoporosis (self-reported) 0.7 0.9 1.5 1.1 1.2 -0.3
Osteoarthritis (self-reported) 0.1 0.1 0.4 0.6 -0.1 0.1
Medication: Aspirin 0.3 0.4 1.0 0.2 -0.4 -1.0
Medication: Gliclazide 0.2 0.2 0.4 0.6 -0.5 -0.2
Illnesses of father: None of the above (group 1) 1.2 1.5 2.9 1.7 1.3 0.2
Smoking status: Current 0.5 0.8 1.2 -1.0 -0.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.4 0.6 0.5 -0.4
Whole body water mass 0.2 1.3 1.9 1.4 -1.2 -0.8
Leg predicted mass (right) 0.4 1.9 3.9 2.0 -0.7 -1.2
Arm fat mass (left) 0.5 2.0 5.0 2.2 -0.0 -0.9
Number of self-reported non-cancer illnesses 0.4 0.8 1.0 -1.0 -0.7 1.0
Average weekly champagne plus white wine intake 0.1 0.2 0.3 0.4 0.3 -0.6
Miserableness 1.1 1.9 2.4 1.6 1.0 -1.5
Guilty feelings 0.3 0.5 0.6 0.8 0.6 -0.8
Wears glasses or contact lenses 0.2 0.2 0.3 0.5 0.6 0.2
Ever taken oral contraceptive pill 0.9 1.0 2.0 1.0 -0.3 -1.4
Hearing aid user 0.9 1.0 2.0 0.9 1.4 -0.2
Mother’s age at death 0.6 0.8 2.1 0.4 1.4 -0.4
Financial situation satisfaction 0.3 0.4 0.7 -0.4 -0.8 0.7
Tinnitus: Yes, now most or all of the time 1.5 1.8 3.0 -1.2 -0.9 1.7
Commuting to job workplace: Public transport 0.8 0.9 1.2 -0.7 -1.1 1.1
Eye problems/disorders: Glaucoma 0.3 0.4 0.6 0.8 0.7 0.1
Medication: Blood pressure 0.7 1.4 2.6 -0.5 -1.1 1.6
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.0 -1.0 -0.6 0.9
Supplements: Fish oil (including cod liver oil) 1.1 1.5 2.2 -1.5 -1.1 1.0
High cholesterol (Self-reported) 0.7 1.2 2.7 -0.7 -0.7 1.6
Medication: Bendroflumethiazide 3.2 4.9 6.2 -1.6 -2.5 2.5
Medication: Paracetamol 0.8 1.3 3.4 -1.8 0.2 0.5
Medication: Lisinopril 5.1 6.5 10.2 -2.5 -1.8 3.2
Medication: Atorvastatin 0.7 0.9 2.1 1.4 0.7 -0.3
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.2 -0.6 0.1
Alcohol drinker status: Never 0.5 0.6 1.1 0.8 1.1 -0.1
Ever smoked 2.2 3.9 8.0 -1.9 -0.4 2.8
Basal metabolic rate 0.3 1.9 3.3 1.8 -1.0 -1.2
Leg fat percentage (left) 0.7 2.6 6.4 2.5 0.4 -1.1
Arm fat-free mass (left) 0.2 1.2 1.5 1.2 -1.2 -0.8
Number of operations (self-reported) 0.4 0.6 0.8 0.7 0.9 -0.8
Average weekly beer plus cider intake 1.0 1.5 2.6 -1.6 -0.9 1.0
Irritability 0.3 0.4 1.1 0.3 0.4 -1.1
Risk taking 0.2 0.4 1.0 0.1 1.0 0.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.3 0.6 1.2 -0.6
Fractured/broken bones in last 5 years 4.3 5.5 8.5 2.9 0.7 -2.7
Age started oral contraceptive pill 0.4 0.6 1.5 1.2 -0.2 -0.4
Diastolic blood pressure, automated reading 0.9 2.7 6.4 2.5 0.7 -1.1
Ever depressed for a whole week 0.9 1.1 2.2 -1.5 -0.6 0.8
Unable to work because of sickness or disability 0.3 0.4 1.3 -0.0 -1.1 0.2
Commuting to job workplace: Cycle 0.3 0.3 0.4 0.6 -0.6 -0.4
Myopia 0.1 0.1 0.2 -0.2 0.5 0.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.6 -0.2 0.8 -0.8
Cholesterol lowering medication 0.2 0.3 0.9 0.0 -0.1 0.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.5 -0.2 -1.2 0.7
Pain experienced in last month 0.4 0.7 1.5 1.2 0.1 -0.8
Supplements: Calcium 0.7 0.7 0.9 0.9 0.8 -0.9
Basal cell carcinoma (self-reported) 0.8 0.9 2.1 1.4 0.3 -0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.4 -1.2 -0.5 0.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 0.2 -0.3 -0.0
Heart disease (siblings) 0.7 0.8 1.5 -0.7 -1.2 0.7
Alcohol drinker status: Previous 0.6 0.7 1.0 -1.0 0.8 0.8
Pack years of smoking 0.2 0.2 0.5 -0.4 0.7 0.3
Impedance of whole body 0.1 0.5 1.2 -1.1 -0.0 0.5
Leg fat mass (left) 0.7 2.6 6.0 2.4 -0.1 -1.3
Arm predicted mass (left) 0.2 1.1 1.6 1.2 -1.2 -0.6