Hub : Genes

LINC00910

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.067	0.038	6.2e-03	0.029	NA	0.004	NA	0.019	9.2e-03	NA	1.8e-01	NA	3.1e-02
2	GTEx	Skin Sun Exposed Lower leg	0.105	0.048	2.7e-03	-0.003	NA	0.017	NA	0.002	7.0e-01	NA	1.3e-02	NA	1.9e-01
3	GTEx	Testis	0.599	0.068	1.5e-13	0.464	NA	0.455	NA	0.473	7.6e-23	NA	2.8e-22	NA	2.1e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.5	-0.4	0.5	1.2
Bipolar Disorder or Schizophrenia	0.2	0.6	1.0	-1.0	0.2	0.9
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.0	-0.1	-0.4
Depression (Nagel 2018)	1.2	1.8	3.7	-1.3	0.3	1.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	0.3	-1.2	1.0
Neuroticism (Nagel 2018)	0.2	0.4	0.6	-0.8	-0.6	0.5
Schizophrenia (2018)	0.2	0.3	0.9	-1.0	-0.1	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.9	-0.7	0.2
Worry (Nagel 2018)	0.4	0.9	2.1	-1.4	-0.6	0.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.2	0.6	-0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.0	0.5	1.0	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.2	0.6	-0.2
Crohns Disease (2017)	1.8	4.0	5.2	2.3	1.6	-2.1
Irritable Bowel Disease (IBD)	1.5	3.5	4.4	2.0	1.3	-2.1
Ulcerative Colitis (UC)	0.4	0.8	1.1	1.1	0.4	-1.1
Major Depression (MDD)	0.2	0.2	0.4	-0.4	0.4	-0.6
Reaction Time	1.8	3.4	6.9	-1.3	-1.3	2.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.8	0.8	-1.4	0.1
Breast Cancer	0.4	1.1	2.9	0.4	1.7	0.4
Ovarian Cancer	2.9	3.8	6.4	-1.7	-1.4	2.5
Prostate Cancer	1.3	1.8	3.0	1.5	0.3	-1.7
Age at First Birth	0.0	0.1	0.2	-0.2	-0.4	0.1
Bipolar Disorder (2011)	0.5	0.5	0.8	-0.8	0.4	0.9
Body Mass Index (BMI) (2010)	3.2	4.4	6.7	2.4	0.9	-2.6
Coronary Artery Disease (CAD)	0.4	0.4	0.9	-0.6	-1.0	-0.0
Crohns Disease (2012)	0.8	1.2	2.0	1.4	0.9	-0.9
Mean Putamen Volume	0.1	0.1	0.4	-0.1	-0.2	-0.6
Fasting Glucose	0.5	0.6	1.3	-1.2	-0.6	0.3
HbA1C	6.7	7.5	7.8	-2.8	-2.8	2.6
HDL Cholesterol	3.1	5.2	8.7	2.2	1.3	-3.0
LDL Cholesterol	0.3	0.4	0.5	0.7	0.6	-0.7
Lupus	2.6	3.9	5.4	-2.3	-1.6	2.0
Neuroticism (2016)	0.2	0.3	0.7	-0.3	0.3	-0.8
Primary Biliary Cirrhosis	0.7	1.0	2.4	-0.1	-1.5	-0.7
Rheumatoid Arthritis	0.1	0.2	0.5	-0.2	-0.1	-0.7
Schizophrenia (2014)	0.6	1.4	3.7	-1.9	-0.2	0.7
Triglycerides	6.5	10.6	17.6	-3.2	-2.0	4.2
Type 2 Diabetes (T2D) (2012)	1.2	1.3	2.4	-1.5	-0.6	1.1
Ulcerative Colitis	0.1	0.1	0.3	0.1	-0.5	-0.1
Blood Eosinophil Count	1.9	14.8	22.2	4.7	1.5	-4.5
Blood Platelet Count	0.0	0.4	0.8	-0.5	0.4	0.9
Blood Red Count	0.0	0.4	1.1	-0.1	-1.1	-0.0
Blood White Count	3.2	24.0	41.3	6.4	0.9	-5.5
Heel T-Score	3.2	25.5	36.0	-6.0	-4.7	4.2
BMI	0.8	4.9	9.4	3.1	0.1	-2.3
Height	0.3	5.8	12.0	1.4	-3.5	-1.9
Waist Hip Ratio (WHR)	1.3	5.8	10.0	-2.0	-1.8	3.2
Systolic Blood Pressure	0.3	1.4	2.6	-1.6	-1.2	0.5
Smoking Status	2.2	5.2	5.5	-2.2	-2.2	2.3
Allergy or Eczema	0.2	0.5	0.9	0.3	0.9	-0.7
Cardiovascular Disease	0.9	2.9	3.7	-1.9	-1.2	1.9
Hypothyroidism (self reported)	0.4	0.9	2.0	-0.1	0.9	-1.4
Respiratory disease	0.7	1.6	4.3	0.4	2.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	-0.9	-1.8	1.1
Lung FEV1/FVC ratio	0.2	0.8	1.7	1.3	-0.3	-0.8
Lung FVC	0.1	0.7	1.2	-0.8	0.3	1.1
Neuroticism	0.1	0.2	0.5	-0.7	-0.5	0.2
Chronotype (morning person)	0.1	0.3	0.6	-0.5	-0.8	0.5
Hair Pigment	0.0	0.7	1.1	0.6	-0.8	-1.1
Tanning	0.1	1.7	2.7	-1.6	-1.1	1.1
Hand grip strength (left)	1.3	3.5	6.8	-2.6	-1.6	1.0
Number of treatments/medications taken	0.3	0.6	1.2	-1.1	-0.5	0.7
Average weekly spirits intake	1.0	1.3	2.0	-1.3	0.4	1.4
Sensitivity / hurt feelings	1.8	3.1	7.1	-1.2	-2.7	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.2	-0.1	1.5	0.3
Hearing difficulty/problems: Yes	0.5	0.7	1.0	0.8	1.0	-0.7
Relative age of first facial hair	1.2	2.5	3.1	-1.7	-1.2	1.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.0	-1.3	-0.7	1.4
Ever used hormone-replacement therapy (HRT)	2.2	2.8	6.6	2.6	0.9	-1.0
Ever had hysterectomy (womb removed)	0.8	0.9	1.3	1.2	1.1	-0.5
Systolic blood pressure, automated reading	0.1	0.3	0.7	0.5	-0.1	-0.8
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	4.7	-1.3	-2.2	1.8
Angina	0.0	0.1	0.1	-0.2	0.1	-0.4
Medication for hormone replacement therapy	0.5	0.5	0.8	0.7	-0.6	-0.9
Vitamin and mineral supplements	1.5	2.1	3.8	2.0	1.4	-0.6
Supplements: Zinc	0.7	0.8	2.3	-1.5	0.0	-0.0
Medication: Co-codamol	0.0	0.0	0.1	0.2	0.1	-0.1
Medication: Metformin	1.8	2.6	7.1	-0.6	-2.7	0.4
Diabetes (father)	0.1	0.1	0.2	-0.0	-0.4	-0.3
Diabetes (mother)	1.4	1.8	3.8	1.2	0.3	-1.9
Severe depression (siblings)	5.1	5.6	8.2	-2.9	-1.2	2.7
Pack years adult smoking proportion	0.2	0.3	0.5	-0.6	0.7	0.2
Impedance of leg (right)	0.4	1.9	4.3	-2.1	-0.7	0.9
Leg fat-free mass (left)	0.4	2.0	4.1	2.0	-0.6	-1.2
Trunk fat percentage	0.6	2.3	5.7	2.4	0.2	-1.1
Hand grip strength (right)	1.7	4.8	10.6	-3.2	-1.3	1.4
Townsend deprivation index at recruitment	0.3	0.4	0.6	0.8	0.7	-0.4
Current tobacco smoking	0.3	0.5	1.0	-0.7	0.4	1.0
Average weekly fortified wine intake	4.2	4.9	8.0	-2.8	-0.7	2.5
Maternal smoking around birth	0.1	0.1	0.4	0.1	0.0	-0.7
Fed-up feelings	0.0	0.0	0.0	0.1	0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.8	0.7	1.3	0.0
Relative age voice broke	3.2	4.9	7.0	-2.6	-1.4	2.4
Taking other prescription medications	0.1	0.1	0.1	-0.4	-0.1	-0.3
Age when periods started (menarche)	0.3	0.7	1.2	-0.9	-1.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-0.5	0.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.3	-1.5	-1.3	1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.3	0.7	-0.0
Qualifications: CSEs or equivalent	0.8	1.1	2.2	-1.5	-1.0	0.1
Serious illness, injury or assault to yourself	0.3	0.4	0.9	0.5	-0.9	-0.0
High blood pressure	0.4	1.1	1.6	-0.0	-1.3	1.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	-0.3	0.4	-0.3
Multivitamins +/- minerals	0.5	0.7	1.3	0.1	-0.8	-1.1
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.5	-0.3	0.4
Supplements: Glucosamine	1.3	1.8	2.5	1.6	1.0	-1.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	-1.1	-0.4	1.3
Medication: Atenolol	0.1	0.1	0.3	-0.1	-0.6	0.1
Medication: Levothyroxine sodium	1.1	1.8	4.5	0.9	0.3	-2.1
Sitting height	0.8	5.3	9.4	3.1	-1.2	-2.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	0.1	-1.2	-0.5
High blood pressure (mother)	0.8	1.1	3.0	0.6	1.7	0.2
Body mass index (BMI)	0.5	2.2	5.4	2.3	0.5	-1.1
Impedance of leg (left)	0.4	1.8	4.2	-2.0	-0.8	0.8
Leg predicted mass (left)	0.4	2.0	4.1	2.0	-0.6	-1.2
Trunk fat mass	0.6	2.6	6.3	2.5	-0.1	-1.2
Waist circumference	0.3	1.3	3.6	1.9	-0.2	-0.3
Number of incorrect matches in round	0.5	0.8	2.5	0.1	-0.2	-1.6
Past tobacco smoking	2.8	5.1	8.4	1.9	1.8	-2.9
Alcohol usually taken with meals	0.3	0.5	0.8	0.3	0.7	-0.9
Nervous feelings	0.2	0.3	0.4	0.7	0.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.9	-1.7	-0.5	1.1
Hearing difficulty/problems with background noise	0.2	0.4	0.5	0.7	0.6	-0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.7	-0.2	-0.3
Had menopause	5.4	6.8	13.8	3.7	1.6	-1.9
Had other major operations	1.7	2.1	3.0	-1.1	-1.5	1.7
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.8	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	3.0	-1.7	-1.2	1.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.1	0.4	-0.1
Qualifications: None of the above	0.1	0.2	0.3	0.4	0.6	0.3
Financial difficulties in last 2 years	0.6	0.9	2.5	-0.3	-0.1	1.6
Mouth/teeth dental problems	0.2	0.3	0.5	0.1	0.5	-0.7
Heart attack	0.4	0.4	1.1	-1.1	-0.4	0.1
Allergy	0.1	0.2	0.4	0.5	-0.6	-0.3
Pain all over the body in last month	0.6	0.7	1.1	0.8	0.5	-1.1
Diabetes (self-reported)	1.4	2.1	4.8	-0.6	-2.2	1.1
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	2.2	1.3	1.4	-1.5
Medication: Ramipril	1.0	1.2	2.9	1.7	0.3	-0.9
Medication: Simvastatin	0.6	0.9	2.3	0.0	-1.5	0.5
Fluid intelligence score	0.1	0.2	0.5	-0.1	-0.7	0.4
Illnesses of siblings	1.2	1.7	4.0	0.1	2.0	-1.1
Neuroticism score	0.1	0.2	0.5	0.1	-0.4	-0.7
Weight	0.5	2.3	5.2	2.3	-0.8	-1.0
Impedance of arm (right)	0.2	1.0	1.6	-1.3	-0.3	1.1
Arm fat percentage (right)	0.4	1.7	4.5	2.1	0.3	-0.8
Trunk fat-free mass	0.2	1.3	1.6	1.3	-1.2	-0.9
Hip circumference	0.9	3.8	7.0	2.6	0.3	-2.1
Time employed in main current job	0.1	0.1	0.3	0.3	-0.0	0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.8	0.0	0.8
Father’s age at death	0.1	0.1	0.2	0.1	-0.5	0.5
Worrier / anxious feelings	0.7	1.4	2.7	-1.6	-1.1	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.3	-1.5	0.1	1.1
Falls in the last year	0.3	0.4	0.8	-0.9	-0.6	0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.5	0.1	0.6
Number of live births	0.1	0.2	0.4	0.2	0.6	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	-0.9	-1.0	0.3
Pulse rate	0.7	1.2	1.5	-0.8	-1.2	1.2
Happiness	0.4	0.5	0.8	0.9	-0.6	0.5
Noisy workplace	0.3	0.3	0.6	0.5	0.4	-0.8
Qualifications: A levels/AS levels or equivalent	2.7	5.9	8.0	2.8	1.5	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	-0.1	-0.6	0.7
Mouth/teeth dental problems: Dentures	1.0	1.6	2.2	-1.0	-1.3	1.5
Asthma	0.3	0.6	1.4	0.2	1.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	-0.4	-0.8	-0.3
Medication: Cholesterol lowering	0.3	0.5	0.8	0.9	-0.7	-0.3
Depression (self-reported)	0.2	0.2	0.4	0.2	0.4	-0.6
Medication: Lansoprazole	0.2	0.3	0.5	-0.7	-0.6	0.0
Prospective memory result	0.3	0.3	0.6	-0.7	0.0	0.6
Lung cancer (father)	0.2	0.2	0.6	0.3	-0.0	-0.8
Illnesses of mother	1.0	1.3	2.6	-1.0	-1.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.1	-0.5	-0.1
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.3	-0.9	0.5
Impedance of arm (left)	0.0	0.2	0.4	-0.6	0.3	0.4
Arm fat mass (right)	0.4	1.6	4.2	2.0	-0.1	-0.8
Trunk predicted mass	0.3	1.4	1.7	1.3	-1.2	-1.0
Standing height	0.3	3.0	8.8	-0.1	-3.0	0.1
Length of working week for main job	1.1	1.2	3.2	-0.5	-0.4	1.8
Exposure to tobacco smoke at home	0.4	0.5	0.8	-0.8	0.0	0.9
Breastfed as a baby	1.3	1.6	2.5	-0.7	-1.6	1.3
Tense / ‘highly strung’	2.1	3.4	5.7	-2.4	-1.7	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.5	-0.8	-0.5	1.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.3	-0.2	0.6
Birth weight of first child	0.0	0.1	0.2	-0.4	0.1	0.1
Peak expiratory flow (PEF)	0.7	1.7	2.9	-1.1	-1.7	1.0
Pulse wave reflection index	0.2	0.2	0.3	0.4	0.5	-0.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.1	-1.0	-0.6	1.1
Loud music exposure frequency	0.2	0.2	0.2	-0.5	-0.4	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	0.6	0.6	-1.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.3	0.2	0.1
Blood clot in the leg (DVT)	0.0	0.1	0.1	0.1	-0.4	0.2
Medication: Paracetamol	0.9	1.4	3.8	-2.0	-0.0	0.7
Headache pain in last month	0.8	1.5	4.2	-2.0	0.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.9	-0.9	1.0	-0.2
Glaucoma (self-reported)	0.2	0.3	0.5	0.3	0.5	0.7
Gout (self-reported)	1.6	2.2	5.0	2.2	-0.0	-1.2
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.1	0.3	0.9	-2.3
Medication: Amlodipine	0.6	0.8	2.3	1.5	0.2	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.7	-0.9	0.2
Birth weight	0.5	1.1	1.6	1.0	-0.9	1.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.1	0.5	-0.6
High blood pressure (siblings)	0.3	0.5	0.8	-0.1	-0.9	0.8
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	-0.2	0.1	0.0
Body fat percentage	0.6	2.4	6.0	2.4	0.4	-1.1
Leg fat percentage (right)	0.7	2.4	6.1	2.5	0.5	-1.0
Arm fat-free mass (right)	0.3	1.4	2.3	1.5	-1.0	-1.0
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-1.0	0.3	0.8
Comparative body size at age 10	0.1	0.4	0.9	0.5	1.0	0.2
Number of full brothers	0.5	0.6	1.6	0.3	1.3	0.4
Worry too long after embarrassment	0.4	0.7	1.2	-0.4	-1.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	0.3	0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.6	0.1	-0.7
Number of children fathered	0.1	0.1	0.4	-0.6	-0.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	5.4	-1.2	-1.0	2.3
Age at first live birth	0.9	1.6	4.0	-0.5	-2.0	0.8
Pulse wave peak to peak time	0.5	0.6	1.1	0.1	1.1	-0.8
Health satisfaction	0.6	0.8	1.2	-0.2	-1.1	1.1
Shortness of breath walking on level ground	0.7	0.8	1.4	-0.7	-0.7	1.2
Qualifications: College or University degree	0.3	0.8	1.5	0.9	0.4	-1.2
Eye problems/disorders: None of the above	1.2	1.4	1.8	1.0	1.1	-1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	0.8	-0.9	-0.5
Emphysema/chronic bronchitis	0.4	0.5	0.7	-0.8	-0.4	0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.8	0.5	-0.1
Neck or shoulder pain in last month	3.0	4.2	6.4	-2.5	-1.7	1.9
Medication: Blood pressure	0.5	0.9	1.8	0.5	-1.3	0.8
Angina (self-reported)	0.1	0.1	0.2	-0.2	0.1	-0.5
Migraine (self-reported)	4.1	5.1	10.2	-3.2	-1.2	2.0
Medication: Ibuprofen	0.8	0.9	1.5	-0.7	-1.2	0.9
Medication: Allopurinol	2.0	2.7	7.3	2.7	-0.2	-0.8
Medication: Omeprazole	0.3	0.4	0.8	0.4	-0.9	0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.1	0.2	0.7
Mean time to correctly identify matches	1.8	3.4	8.2	-0.8	-1.2	2.9
Heart disease (mother)	0.4	0.5	1.2	-0.2	1.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	6.4	1.0	2.5	-1.3
Whole body fat mass	0.6	2.6	6.2	2.5	0.1	-1.3
Leg fat mass (right)	0.6	2.4	5.8	2.4	-0.1	-1.2
Arm predicted mass (right)	0.3	1.5	2.2	1.5	-1.2	-1.0
Pulse rate, automated reading	1.1	3.4	3.9	-1.7	-2.0	1.8
Alcohol intake frequency.	0.2	0.5	1.4	-0.3	1.2	0.1
Comparative height size at age 10	0.5	2.5	3.4	1.0	-1.8	-1.8
Number of full sisters	2.0	2.5	3.9	1.7	0.8	-2.0
Suffer from ‘nerves’	0.5	0.8	1.6	-1.3	-0.8	0.4
Overall health rating	0.9	1.9	2.7	-1.1	-1.3	1.6
Chest pain or discomfort	1.7	2.4	5.0	-2.2	-0.5	1.4
Had major operations	0.2	0.3	0.5	0.2	-0.7	-0.6
Age at last live birth	2.2	3.2	5.9	-1.3	-2.4	1.4
Family relationship satisfaction	0.6	0.8	2.1	1.5	-0.4	0.3
Leg pain on walking	0.5	0.7	1.5	-1.2	0.3	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.4	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	3.6	4.4	6.4	2.2	1.4	-2.5
Medication: Aspirin	0.8	1.0	2.3	0.7	-0.3	-1.5
Supplements: Vitamin C	3.7	4.3	8.0	-2.8	-1.1	2.0
Knee pain experienced in last month	0.2	0.3	0.3	0.5	0.5	-0.5
Hypertension (Self-reported)	0.4	1.2	2.3	-0.2	-1.1	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.4	0.7	0.6	-0.5
Illnesses of father: Heart disease	0.9	1.2	3.2	-1.8	-0.7	0.2
Illnesses of siblings: Diabetes	0.6	0.8	1.2	-0.8	-1.1	0.7
Smoking status: Previous	3.1	4.6	6.3	-1.5	-2.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	1.1	-0.4	-0.5
Whole body fat-free mass	0.3	1.5	2.4	1.6	-1.1	-1.0
Leg fat-free mass (right)	0.3	1.9	3.7	1.9	-0.7	-1.2
Arm fat percentage (left)	0.6	2.4	5.9	2.4	0.6	-1.1
Average weekly red wine intake	1.6	2.3	5.0	-2.2	-0.8	1.1
Handedness (chirality/laterality): Left-handed	2.2	2.7	6.0	-2.4	-0.6	1.3
Mood swings	0.3	0.5	1.1	-0.5	-1.1	0.2
Loneliness, isolation	3.6	5.0	6.5	2.3	1.8	-2.6
Long-standing illness, disability or infirmity	2.1	3.2	5.2	-1.9	-1.0	2.3
Ever had bowel cancer screening	0.2	0.2	0.5	0.2	0.7	-0.3
Diabetes diagnosed by doctor	1.9	3.2	6.0	-1.0	-2.4	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	-0.2	-1.2	0.0
Friendships satisfaction	0.2	0.2	0.4	0.6	-0.5	-0.2
Qualifications: nursing, teaching	1.1	1.8	3.7	-1.9	-0.2	1.2
Commuting to job workplace: Walk	1.7	1.8	2.8	0.9	1.7	-1.3
Eye problems/disorders: Cataract	1.6	1.9	2.9	-1.1	-1.7	1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	0.6	1.0	-0.2
Medication for cholesterol	0.3	0.5	0.7	-0.7	0.9	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.2	-0.1	0.2
Back pain experienced in last month	0.1	0.2	0.3	0.3	-0.6	0.4
Mineral and other dietary supplements	0.1	0.1	0.2	0.4	-0.4	0.1
Breast cancer (self-reported)	0.2	0.3	0.5	0.7	0.3	-0.5
Asthma (self-reported)	0.5	1.0	1.8	0.5	1.3	-1.0
Osteoporosis (self-reported)	0.7	0.9	1.5	1.1	1.2	-0.3
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.6	-0.1	0.1
Medication: Aspirin	0.3	0.4	1.0	0.2	-0.4	-1.0
Medication: Gliclazide	0.2	0.2	0.4	0.6	-0.5	-0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	1.7	1.3	0.2
Smoking status: Current	0.5	0.8	1.2	-1.0	-0.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	0.6	0.5	-0.4
Whole body water mass	0.2	1.3	1.9	1.4	-1.2	-0.8
Leg predicted mass (right)	0.4	1.9	3.9	2.0	-0.7	-1.2
Arm fat mass (left)	0.5	2.0	5.0	2.2	-0.0	-0.9
Number of self-reported non-cancer illnesses	0.4	0.8	1.0	-1.0	-0.7	1.0
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.4	0.3	-0.6
Miserableness	1.1	1.9	2.4	1.6	1.0	-1.5
Guilty feelings	0.3	0.5	0.6	0.8	0.6	-0.8
Wears glasses or contact lenses	0.2	0.2	0.3	0.5	0.6	0.2
Ever taken oral contraceptive pill	0.9	1.0	2.0	1.0	-0.3	-1.4
Hearing aid user	0.9	1.0	2.0	0.9	1.4	-0.2
Mother’s age at death	0.6	0.8	2.1	0.4	1.4	-0.4
Financial situation satisfaction	0.3	0.4	0.7	-0.4	-0.8	0.7
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.0	-1.2	-0.9	1.7
Commuting to job workplace: Public transport	0.8	0.9	1.2	-0.7	-1.1	1.1
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	0.8	0.7	0.1
Medication: Blood pressure	0.7	1.4	2.6	-0.5	-1.1	1.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.0	-1.0	-0.6	0.9
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.2	-1.5	-1.1	1.0
High cholesterol (Self-reported)	0.7	1.2	2.7	-0.7	-0.7	1.6
Medication: Bendroflumethiazide	3.2	4.9	6.2	-1.6	-2.5	2.5
Medication: Paracetamol	0.8	1.3	3.4	-1.8	0.2	0.5
Medication: Lisinopril	5.1	6.5	10.2	-2.5	-1.8	3.2
Medication: Atorvastatin	0.7	0.9	2.1	1.4	0.7	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	-0.6	0.1
Alcohol drinker status: Never	0.5	0.6	1.1	0.8	1.1	-0.1
Ever smoked	2.2	3.9	8.0	-1.9	-0.4	2.8
Basal metabolic rate	0.3	1.9	3.3	1.8	-1.0	-1.2
Leg fat percentage (left)	0.7	2.6	6.4	2.5	0.4	-1.1
Arm fat-free mass (left)	0.2	1.2	1.5	1.2	-1.2	-0.8
Number of operations (self-reported)	0.4	0.6	0.8	0.7	0.9	-0.8
Average weekly beer plus cider intake	1.0	1.5	2.6	-1.6	-0.9	1.0
Irritability	0.3	0.4	1.1	0.3	0.4	-1.1
Risk taking	0.2	0.4	1.0	0.1	1.0	0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	0.6	1.2	-0.6
Fractured/broken bones in last 5 years	4.3	5.5	8.5	2.9	0.7	-2.7
Age started oral contraceptive pill	0.4	0.6	1.5	1.2	-0.2	-0.4
Diastolic blood pressure, automated reading	0.9	2.7	6.4	2.5	0.7	-1.1
Ever depressed for a whole week	0.9	1.1	2.2	-1.5	-0.6	0.8
Unable to work because of sickness or disability	0.3	0.4	1.3	-0.0	-1.1	0.2
Commuting to job workplace: Cycle	0.3	0.3	0.4	0.6	-0.6	-0.4
Myopia	0.1	0.1	0.2	-0.2	0.5	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	-0.2	0.8	-0.8
Cholesterol lowering medication	0.2	0.3	0.9	0.0	-0.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	-0.2	-1.2	0.7
Pain experienced in last month	0.4	0.7	1.5	1.2	0.1	-0.8
Supplements: Calcium	0.7	0.7	0.9	0.9	0.8	-0.9
Basal cell carcinoma (self-reported)	0.8	0.9	2.1	1.4	0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	-1.2	-0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.2	-0.3	-0.0
Heart disease (siblings)	0.7	0.8	1.5	-0.7	-1.2	0.7
Alcohol drinker status: Previous	0.6	0.7	1.0	-1.0	0.8	0.8
Pack years of smoking	0.2	0.2	0.5	-0.4	0.7	0.3
Impedance of whole body	0.1	0.5	1.2	-1.1	-0.0	0.5
Leg fat mass (left)	0.7	2.6	6.0	2.4	-0.1	-1.3
Arm predicted mass (left)	0.2	1.1	1.6	1.2	-1.2	-0.6