Hub : Genes

LIPC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0843 0.0210 8.5e-08 0.022 0.038 0.032 0.04 0.021 1.1e-07 1.9e-12 1.1e-10 8.7e-13 1.4e-07
2 TCGA Lung Squamous Cell Carcinoma 0.1088 0.0427 2.1e-03 0.028 0.004 0.000 NA 0.002 3.4e-04 1.0e-01 3.5e-01 NA 1.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 1.5 0.1 1.2
Bipolar Disorder or Schizophrenia 1.1 2.7 4.7 2.2 0.9
Depressed Affect (Nagel 2018) 1.5 3.1 3.3 -1.7 -1.8
Depression (Nagel 2018) 0.2 0.2 0.3 -0.4 -0.6
Intelligence (Savage-Jansen 2018) 0.8 2.6 2.6 1.6 1.6
Neuroticism (Nagel 2018) 0.8 1.9 2.8 -1.7 -1.0
Schizophrenia (2018) 1.8 3.7 7.3 2.7 0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 0.8 -0.4
Worry (Nagel 2018) 0.1 0.2 0.3 -0.6 -0.1
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 -0.8 0.2
Alzheimer’s Disease (in father) 1.1 1.2 2.0 -0.7 1.4
Alzheimer’s Disease (including proxy) 1.7 2.5 4.9 -2.2 0.3
Crohns Disease (2017) 0.9 2.0 3.4 -1.8 0.8
Irritable Bowel Disease (IBD) 0.8 2.0 2.4 -1.6 1.3
Ulcerative Colitis (UC) 0.5 0.9 1.6 -0.5 1.2
Major Depression (MDD) 1.0 1.3 1.6 -1.3 -1.0
Reaction Time 1.4 2.7 2.7 1.6 1.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.7 0.8 0.5
Breast Cancer 0.8 1.8 3.0 0.8 1.7
Ovarian Cancer 0.4 0.5 0.9 -0.4 -1.0
Prostate Cancer 0.4 0.5 0.7 0.8 -0.6
Age at First Birth 0.1 0.2 0.3 -0.6 -0.2
Bipolar Disorder (2011) 0.7 0.7 1.4 1.2 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.3 -0.3 0.5
Coronary Artery Disease (CAD) 2.4 2.9 5.2 -2.3 -0.8
Crohns Disease (2012) 0.0 0.0 0.1 0.3 0.2
Mean Putamen Volume 0.6 0.7 1.3 -0.2 1.1
Fasting Glucose 1.2 1.5 1.9 -1.4 1.0
HbA1C 1.5 1.6 2.5 0.9 1.6
HDL Cholesterol 71.8 119.7 185.0 7.4 -13.6
LDL Cholesterol 1.6 2.6 3.1 1.5 1.7
Lupus 0.3 0.4 0.5 0.7 -0.5
Neuroticism (2016) 1.3 1.9 3.4 -0.6 1.8
Primary Biliary Cirrhosis 0.1 0.2 0.3 0.1 -0.6
Rheumatoid Arthritis 0.1 0.1 0.2 -0.2 -0.4
Schizophrenia (2014) 1.2 2.6 5.2 2.3 -0.0
Triglycerides 7.5 12.2 23.4 1.0 -4.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.6 0.7 0.2
Ulcerative Colitis 0.2 0.3 0.5 0.2 0.7
Blood Eosinophil Count 1.8 14.0 15.6 4.0 3.5
Blood Platelet Count 0.0 0.1 0.1 -0.3 -0.0
Blood Red Count 0.9 9.0 9.7 -2.9 3.1
Blood White Count 0.6 4.5 7.0 2.6 1.4
Heel T-Score 0.0 0.0 0.0 -0.2 0.1
BMI 0.2 1.0 1.5 -0.7 1.2
Height 0.0 0.2 0.3 -0.1 0.5
Waist Hip Ratio (WHR) 1.2 5.5 10.1 -3.2 0.9
Systolic Blood Pressure 0.1 0.7 1.1 -1.1 -0.5
Smoking Status 2.1 5.1 5.3 2.2 2.3
Allergy or Eczema 0.2 0.6 0.9 1.0 0.4
Cardiovascular Disease 0.8 2.6 4.9 -0.5 -2.2
Hypothyroidism (self reported) 0.9 2.1 4.2 -2.0 -0.3
Respiratory disease 0.4 1.0 1.4 1.2 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.9 -1.0 0.2
Lung FEV1/FVC ratio 0.4 2.0 3.9 -0.1 -2.0
Lung FVC 0.5 2.7 4.3 1.0 2.1
Neuroticism 0.2 0.6 1.1 -1.1 -0.2
Chronotype (morning person) 0.2 0.5 0.8 0.5 0.9
Hair Pigment 0.0 0.1 0.2 0.1 -0.4
Tanning 0.2 1.9 3.4 0.6 -1.8
Hand grip strength (left) 0.1 0.1 0.2 0.3 0.4
Number of treatments/medications taken 0.4 0.8 1.0 -1.0 -0.8
Average weekly spirits intake 0.3 0.4 0.5 -0.7 0.5
Sensitivity / hurt feelings 0.9 1.5 1.7 -1.3 -1.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.0 -1.4 -0.3
Hearing difficulty/problems: Yes 0.5 0.8 1.1 1.0 -0.7
Relative age of first facial hair 1.1 2.3 2.9 1.7 1.3
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 5.4 -0.8 -2.3
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.2 -1.1 0.5
Ever had hysterectomy (womb removed) 0.9 1.0 1.0 -1.0 1.0
Systolic blood pressure, automated reading 0.6 1.7 3.3 -1.8 -0.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.8 -0.5 -1.3
Angina 1.6 2.1 4.2 -0.1 -2.0
Medication for hormone replacement therapy 1.5 1.7 3.2 0.3 -1.8
Vitamin and mineral supplements 1.3 1.8 3.4 0.4 1.8
Supplements: Zinc 0.1 0.1 0.1 0.4 -0.1
Medication: Co-codamol 0.4 0.5 0.9 -1.0 -0.4
Medication: Metformin 0.8 1.1 2.0 -1.4 -0.5
Diabetes (father) 0.3 0.3 0.5 0.7 -0.4
Diabetes (mother) 0.1 0.1 0.1 -0.3 0.3
Severe depression (siblings) 0.9 1.0 1.2 1.1 0.9
Pack years adult smoking proportion 1.2 1.8 2.3 -1.1 -1.5
Impedance of leg (right) 0.5 2.3 2.3 -1.5 -1.5
Leg fat-free mass (left) 0.2 1.3 2.3 0.6 1.5
Trunk fat percentage 0.3 1.3 2.4 -1.5 0.6
Hand grip strength (right) 0.2 0.5 1.0 -0.1 1.0
Townsend deprivation index at recruitment 0.5 0.7 1.1 -0.5 -1.1
Current tobacco smoking 0.1 0.2 0.4 0.7 -0.0
Average weekly fortified wine intake 0.2 0.3 0.4 -0.4 -0.6
Maternal smoking around birth 0.2 0.3 0.6 -0.8 0.1
Fed-up feelings 0.6 1.1 1.8 -0.7 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.2 -2.0 -0.0
Relative age voice broke 1.5 2.3 3.2 1.2 1.8
Taking other prescription medications 0.7 1.1 1.8 -1.3 0.7
Age when periods started (menarche) 0.3 0.7 1.3 1.1 -0.5
Bilateral oophorectomy (both ovaries removed) 4.7 5.5 6.9 -2.0 -2.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.1 1.1 0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 -0.9 0.1
Qualifications: CSEs or equivalent 0.0 0.0 0.1 0.2 -0.0
Serious illness, injury or assault to yourself 1.3 1.6 3.2 -1.8 0.2
High blood pressure 1.0 2.8 5.4 -2.3 -0.5
Hayfever, allergic rhinitis or eczema 1.9 4.2 4.8 1.9 2.2
Multivitamins +/- minerals 1.4 1.8 3.0 -0.8 -1.7
Stomach or abdominal pain in last month 1.2 1.4 1.8 -1.3 -1.1
Supplements: Glucosamine 0.1 0.1 0.1 -0.4 0.0
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 4.7 -2.2 0.1
Medication: Atenolol 0.4 0.5 0.5 -0.6 -0.7
Medication: Levothyroxine sodium 2.6 4.3 4.5 -2.1 -2.1
Sitting height 0.2 1.5 1.7 1.3 1.1
Chronic bronchitis/emphysema (father) 2.1 2.5 4.3 -2.1 -0.8
High blood pressure (mother) 2.4 3.4 5.0 -2.2 -1.4
Body mass index (BMI) 0.2 0.8 1.0 -0.8 1.0
Impedance of leg (left) 0.6 2.9 4.2 -2.1 -1.3
Leg predicted mass (left) 0.3 1.4 2.4 0.6 1.6
Trunk fat mass 0.3 1.1 1.7 -1.3 0.7
Waist circumference 0.5 1.8 2.6 -1.0 1.6
Number of incorrect matches in round 0.2 0.4 0.7 -0.2 -0.8
Past tobacco smoking 3.4 6.3 8.0 -2.1 -2.8
Alcohol usually taken with meals 0.6 1.0 1.5 0.7 1.2
Nervous feelings 0.9 1.6 2.3 -1.0 1.5
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 3.8 -2.0 -0.5
Hearing difficulty/problems with background noise 0.3 0.5 0.9 -0.3 0.9
Hair/balding pattern: Pattern 2 0.3 0.4 0.5 -0.7 0.6
Had menopause 0.6 0.8 1.6 0.0 1.3
Had other major operations 1.2 1.5 2.1 0.9 1.4
Forced vital capacity (FVC) 0.3 1.3 1.5 1.2 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.2 0.5 -0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.7 -0.1 0.8
Qualifications: None of the above 0.3 0.6 0.7 -0.9 -0.7
Financial difficulties in last 2 years 0.5 0.7 1.1 -1.0 0.6
Mouth/teeth dental problems 0.9 1.3 2.6 1.6 0.0
Heart attack 2.0 2.6 5.2 -0.0 -2.3
Allergy 1.8 4.1 4.7 -2.2 -1.9
Pain all over the body in last month 0.2 0.2 0.2 -0.5 -0.5
Diabetes (self-reported) 0.6 0.9 1.5 -1.2 -0.5
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.3 0.6 0.2
Medication: Ramipril 0.4 0.6 1.1 0.0 1.1
Medication: Simvastatin 0.8 1.2 2.4 0.1 -1.6
Fluid intelligence score 0.2 0.4 0.7 -0.3 0.9
Illnesses of siblings 0.1 0.2 0.3 0.6 -0.0
Neuroticism score 0.3 0.6 1.1 -1.1 0.4
Weight 0.2 1.0 1.7 -0.4 1.3
Impedance of arm (right) 0.2 1.0 1.8 -0.5 -1.4
Arm fat percentage (right) 0.1 0.4 0.7 -0.8 0.5
Trunk fat-free mass 0.1 0.6 0.9 0.6 1.0
Hip circumference 0.3 1.4 2.5 0.5 1.6
Time employed in main current job 1.8 2.1 4.2 2.0 -0.1
Alcohol intake versus 10 years previously 1.3 1.9 2.2 -1.5 -1.3
Father’s age at death 1.0 1.3 1.5 1.2 1.1
Worrier / anxious feelings 0.1 0.2 0.4 -0.6 -0.2
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 4.1 -2.0 -1.8
Falls in the last year 0.6 0.9 1.0 -1.0 -0.9
Hair/balding pattern: Pattern 3 1.1 1.6 2.5 -0.9 -1.6
Number of live births 0.6 0.8 1.6 -1.3 -0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.2 1.1 0.0
Pulse rate 0.3 0.4 0.5 0.6 0.7
Happiness 1.4 1.7 2.6 -0.9 -1.6
Noisy workplace 0.2 0.2 0.3 -0.6 0.4
Qualifications: A levels/AS levels or equivalent 2.0 4.4 5.6 2.4 1.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.2 -0.4 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 -0.0 -0.8
Asthma 0.7 1.3 1.9 0.8 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 0.3 0.1
Medication: Cholesterol lowering 1.2 1.9 3.4 0.6 -1.9
Depression (self-reported) 2.7 3.2 3.2 1.8 1.8
Medication: Lansoprazole 1.4 1.6 3.2 -0.1 -1.8
Prospective memory result 3.0 3.7 7.2 2.7 0.5
Lung cancer (father) 0.5 0.5 0.6 -0.8 -0.7
Illnesses of mother 1.7 2.1 2.9 1.7 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.5 1.2 -0.5
Pulse wave Arterial Stiffness index 0.8 1.0 1.7 1.3 0.5
Impedance of arm (left) 0.2 0.8 1.3 -0.4 -1.2
Arm fat mass (right) 0.2 0.7 0.7 -0.8 0.8
Trunk predicted mass 0.1 0.7 1.0 0.6 1.0
Standing height 0.0 0.4 0.6 0.4 0.7
Length of working week for main job 0.2 0.2 0.3 0.3 -0.6
Exposure to tobacco smoke at home 1.0 1.2 2.3 -0.1 -1.5
Breastfed as a baby 0.5 0.6 1.0 0.5 1.0
Tense / ‘highly strung’ 0.9 1.4 1.7 -1.3 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.2 7.8 -2.8 -0.8
Hair/balding pattern: Pattern 4 0.1 0.2 0.2 0.4 -0.5
Birth weight of first child 1.3 2.3 3.6 -1.0 -1.9
Peak expiratory flow (PEF) 0.1 0.2 0.2 0.5 -0.4
Pulse wave reflection index 0.4 0.5 0.7 0.9 0.4
Ever highly irritable/argumentative for 2 days 2.1 2.5 2.9 1.4 1.7
Loud music exposure frequency 0.1 0.1 0.1 0.2 -0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.2 0.6
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 1.4 -1.2 1.2
Blood clot in the leg (DVT) 0.6 0.8 1.6 0.0 1.2
Medication: Paracetamol 0.1 0.2 0.3 -0.4 0.6
Headache pain in last month 0.1 0.2 0.4 -0.7 0.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.2 0.4 1.1
Glaucoma (self-reported) 0.7 0.9 1.2 1.1 0.7
Gout (self-reported) 0.4 0.6 0.6 -0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 5.0 -2.2 -0.6
Medication: Amlodipine 1.7 2.4 4.3 -2.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.6 -0.2 1.6
Birth weight 0.2 0.4 0.6 0.8 0.4
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.1 -0.3 -0.1
High blood pressure (siblings) 2.1 3.0 5.4 -2.3 -0.8
Forced vital capacity (FVC), Best measure 0.4 1.4 2.0 1.4 0.9
Body fat percentage 0.4 1.5 2.7 -1.6 0.5
Leg fat percentage (right) 0.5 1.7 3.2 -1.8 0.5
Arm fat-free mass (right) 0.3 1.7 3.3 0.4 1.8
Exposure to tobacco smoke outside home 0.0 0.0 0.0 -0.2 -0.2
Comparative body size at age 10 0.0 0.1 0.1 0.2 0.3
Number of full brothers 1.0 1.3 1.4 1.2 -1.1
Worry too long after embarrassment 0.6 1.1 1.7 -0.7 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 -0.3 -1.0
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 -0.9 0.2
Number of children fathered 0.6 0.7 1.2 -0.4 1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 1.4 1.1 1.2
Age at first live birth 0.5 0.8 1.2 1.1 0.7
Pulse wave peak to peak time 1.1 1.3 2.2 -1.5 -0.6
Health satisfaction 0.9 1.2 1.5 -1.0 -1.2
Shortness of breath walking on level ground 0.9 1.0 1.5 -0.7 -1.2
Qualifications: College or University degree 2.0 6.4 8.1 2.2 2.8
Eye problems/disorders: None of the above 0.8 0.9 1.8 -1.3 -0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.4 0.6 -0.7 0.6
Emphysema/chronic bronchitis 0.6 0.6 1.2 -0.1 -1.1
Medication for pain relief, constipation, heartburn 0.0 0.0 0.0 -0.1 -0.1
Neck or shoulder pain in last month 1.2 1.6 2.1 1.1 -1.5
Medication: Blood pressure 0.6 1.1 2.2 -1.5 0.1
Angina (self-reported) 1.2 1.6 3.1 0.1 -1.8
Migraine (self-reported) 0.2 0.2 0.4 0.6 0.2
Medication: Ibuprofen 0.2 0.2 0.4 0.0 0.6
Medication: Allopurinol 0.1 0.2 0.3 0.2 -0.5
Medication: Omeprazole 0.1 0.1 0.1 -0.2 -0.3
Medication: Seretide 50 evohaler 0.4 0.4 0.7 0.4 -0.8
Mean time to correctly identify matches 0.6 1.2 1.7 1.3 0.8
Heart disease (mother) 0.3 0.4 0.5 0.6 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.7 -0.9 -0.3
Whole body fat mass 0.3 1.4 2.2 -1.5 0.8
Leg fat mass (right) 0.3 1.2 1.7 -1.3 0.9
Arm predicted mass (right) 0.2 1.0 1.9 0.2 1.4
Pulse rate, automated reading 0.2 0.5 1.0 -1.0 -0.0
Alcohol intake frequency. 0.4 0.9 1.8 -1.3 -0.4
Comparative height size at age 10 0.0 0.2 0.4 -0.6 0.0
Number of full sisters 4.6 5.6 11.0 -3.3 0.5
Suffer from ‘nerves’ 0.4 0.7 1.0 1.0 0.6
Overall health rating 1.1 2.3 3.9 -2.0 -0.9
Chest pain or discomfort 0.1 0.1 0.2 0.3 0.4
Had major operations 0.9 1.0 2.0 -1.4 -0.3
Age at last live birth 0.4 0.6 1.2 -0.0 1.1
Family relationship satisfaction 0.3 0.3 0.6 0.2 0.8
Leg pain on walking 2.2 2.8 4.8 0.9 -2.2
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 2.0 -1.4 -1.1
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.2 -0.2 -1.8
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.8 1.7 -0.7
Medication: Aspirin 0.1 0.2 0.3 0.6 0.0
Supplements: Vitamin C 1.0 1.2 2.4 0.1 -1.5
Knee pain experienced in last month 2.3 3.5 5.5 -1.3 -2.3
Hypertension (Self-reported) 0.8 2.2 4.4 -2.1 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 3.7 1.9 -0.2
Illnesses of father: Heart disease 0.7 1.0 1.7 0.5 -1.3
Illnesses of siblings: Diabetes 0.4 0.5 0.7 -0.8 0.6
Smoking status: Previous 1.5 2.2 3.6 0.9 1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 -0.1 0.1
Whole body fat-free mass 0.2 1.1 1.9 0.5 1.4
Leg fat-free mass (right) 0.3 1.4 2.5 0.5 1.6
Arm fat percentage (left) 0.1 0.5 0.7 -0.9 0.6
Average weekly red wine intake 0.2 0.3 0.5 -0.7 -0.1
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.1 -1.1 0.8
Mood swings 1.4 2.6 4.4 -2.1 -0.9
Loneliness, isolation 0.1 0.1 0.1 -0.2 -0.3
Long-standing illness, disability or infirmity 0.1 0.2 0.3 0.2 -0.6
Ever had bowel cancer screening 0.8 0.9 1.6 -0.5 1.3
Diabetes diagnosed by doctor 0.7 1.2 2.1 -1.4 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 -0.1 0.6
Friendships satisfaction 0.4 0.5 0.5 0.7 0.7
Qualifications: nursing, teaching 0.1 0.2 0.3 0.5 0.3
Commuting to job workplace: Walk 2.5 2.8 4.8 0.9 2.2
Eye problems/disorders: Cataract 0.6 0.7 1.4 1.2 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 3.9 -2.0 0.4
Medication for cholesterol 2.0 3.0 4.4 1.3 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 0.3 0.7
Back pain experienced in last month 3.2 4.7 5.1 -2.3 -2.1
Mineral and other dietary supplements 1.1 1.5 2.8 0.3 1.7
Breast cancer (self-reported) 0.9 1.0 1.9 1.4 0.4
Asthma (self-reported) 0.9 1.8 2.2 1.1 1.5
Osteoporosis (self-reported) 0.8 0.9 1.9 -1.4 -0.2
Osteoarthritis (self-reported) 0.2 0.3 0.3 -0.5 0.6
Medication: Aspirin 0.1 0.1 0.1 0.3 0.3
Medication: Gliclazide 0.4 0.4 0.9 -0.9 -0.1
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 0.2 -0.1
Smoking status: Current 0.4 0.6 1.1 1.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 0.5 -0.0
Whole body water mass 0.2 1.1 1.7 0.6 1.3
Leg predicted mass (right) 0.3 1.5 2.7 0.5 1.6
Arm fat mass (left) 0.2 0.6 0.7 -0.8 0.7
Number of self-reported non-cancer illnesses 0.0 0.0 0.1 -0.2 -0.2
Average weekly champagne plus white wine intake 0.8 1.1 1.7 0.7 1.3
Miserableness 0.7 1.2 1.3 -1.1 -1.1
Guilty feelings 2.0 3.0 5.6 0.6 2.4
Wears glasses or contact lenses 0.2 0.2 0.4 0.0 0.6
Ever taken oral contraceptive pill 0.3 0.3 0.4 0.6 -0.5
Hearing aid user 0.0 0.0 0.0 0.1 -0.0
Mother’s age at death 0.6 0.7 1.2 0.5 1.1
Financial situation satisfaction 1.1 1.3 2.0 -1.4 -0.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 -0.5 0.0
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.3 0.8
Eye problems/disorders: Glaucoma 2.4 2.8 3.1 1.8 1.6
Medication: Blood pressure 0.7 1.4 2.8 -1.7 0.2
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.2 -1.5 -0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.2 0.4 -1.5
High cholesterol (Self-reported) 3.0 5.3 5.5 2.2 -2.4
Medication: Bendroflumethiazide 0.2 0.2 0.5 -0.7 -0.1
Medication: Paracetamol 0.7 1.1 1.1 -1.1 1.0
Medication: Lisinopril 0.2 0.2 0.5 -0.1 -0.7
Medication: Atorvastatin 1.1 1.3 2.2 0.7 -1.5
Illnesses of father: High blood pressure 1.0 1.2 1.8 -0.8 1.3
Alcohol drinker status: Never 1.7 2.1 3.4 -0.9 1.8
Ever smoked 6.0 10.5 12.1 3.0 3.5
Basal metabolic rate 0.2 1.0 1.9 0.4 1.4
Leg fat percentage (left) 0.7 2.6 4.1 -2.0 1.0
Arm fat-free mass (left) 0.2 1.3 2.2 0.6 1.5
Number of operations (self-reported) 1.9 2.9 4.0 -2.0 1.3
Average weekly beer plus cider intake 0.8 1.1 2.3 -1.5 0.1
Irritability 0.5 0.8 1.6 -1.2 -0.1
Risk taking 0.6 0.9 1.7 0.4 1.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.5 0.1
Fractured/broken bones in last 5 years 0.4 0.5 1.0 0.1 -1.0
Age started oral contraceptive pill 1.4 1.8 3.0 0.8 1.7
Diastolic blood pressure, automated reading 0.3 1.1 2.1 -1.4 -0.3
Ever depressed for a whole week 0.8 0.9 1.9 -0.1 1.4
Unable to work because of sickness or disability 4.5 5.8 6.5 -2.6 -2.2
Commuting to job workplace: Cycle 0.6 0.7 1.3 -1.1 -0.2
Myopia 1.0 1.4 2.6 0.4 1.6
Vascular/heart problems diagnosed by doctor 1.0 2.7 4.5 2.1 0.9
Cholesterol lowering medication 1.0 1.5 1.6 1.2 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 -0.0 0.1
Pain experienced in last month 1.8 3.0 4.0 1.4 2.0
Supplements: Calcium 0.9 1.0 1.1 1.1 -1.0
Basal cell carcinoma (self-reported) 1.3 1.5 3.0 0.3 1.7
Heart attack/myocardial infarction (self-reported) 1.4 1.8 3.5 0.1 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.0 0.2 1.4
Heart disease (siblings) 2.4 3.0 5.4 -0.8 -2.3
Alcohol drinker status: Previous 0.1 0.1 0.3 0.5 -0.1
Pack years of smoking 1.3 1.9 2.8 -1.0 -1.7
Impedance of whole body 0.4 2.0 2.1 -1.4 -1.4
Leg fat mass (left) 0.4 1.6 1.8 -1.3 1.2
Arm predicted mass (left) 0.3 1.3 2.0 0.8 1.4