Hub : Genes

LMCD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Kidney Renal Clear Cell Carcinoma 0.0797 0.0299 3.7e-05 0.001 0.039 0.039 NA 0.016 0.2700 2.9e-05 3.3e-05 NA 0.00520
2 TCGA Skin Cutaneous Melanoma 0.1720 0.0930 4.3e-03 0.099 0.027 0.134 NA 0.128 0.0013 6.5e-02 2.0e-04 NA 0.00027

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 2.3 1.5 -0.7
Bipolar Disorder or Schizophrenia 0.3 0.7 0.9 0.9 -0.7
Depressed Affect (Nagel 2018) 0.0 0.1 0.1 0.3 -0.2
Depression (Nagel 2018) 2.1 3.2 4.2 1.5 -2.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.2 -1.8 0.6
Neuroticism (Nagel 2018) 0.3 0.7 1.3 0.2 -1.1
Schizophrenia (2018) 0.0 0.0 0.1 0.1 -0.3
Schizophrenia vs Biploar Disorder 1.7 2.3 4.4 -2.1 0.3
Worry (Nagel 2018) 0.5 1.0 2.0 -0.0 -1.4
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.2 -0.1
Alzheimer’s Disease (in father) 1.2 1.3 1.9 -0.8 1.4
Alzheimer’s Disease (including proxy) 1.0 1.5 2.0 -1.0 1.4
Crohns Disease (2017) 0.0 0.0 0.0 -0.1 0.2
Irritable Bowel Disease (IBD) 0.2 0.5 0.6 0.6 0.8
Ulcerative Colitis (UC) 0.5 0.9 1.0 0.9 1.0
Major Depression (MDD) 0.9 1.1 1.7 1.3 -0.8
Reaction Time 2.5 4.8 7.8 1.4 -2.8
Verbal and Numeric Reasoning (VNR) 0.8 1.9 2.2 -1.5 1.2
Breast Cancer 1.7 4.0 4.6 1.9 -2.1
Ovarian Cancer 0.1 0.1 0.2 0.5 0.2
Prostate Cancer 0.0 0.0 0.0 0.2 0.1
Age at First Birth 0.1 0.2 0.3 0.6 0.3
Bipolar Disorder (2011) 2.5 2.4 4.3 0.7 -2.1
Body Mass Index (BMI) (2010) 4.2 5.8 7.6 -2.0 2.8
Coronary Artery Disease (CAD) 0.3 0.3 0.6 0.3 -0.8
Crohns Disease (2012) 0.0 0.1 0.1 0.2 -0.3
Mean Putamen Volume 1.6 1.8 2.5 1.0 -1.6
Fasting Glucose 0.4 0.5 0.7 -0.8 0.5
HbA1C 0.5 0.5 0.6 -0.8 0.7
HDL Cholesterol 0.0 0.0 0.1 0.3 0.1
LDL Cholesterol 0.1 0.2 0.3 -0.2 -0.5
Lupus 0.3 0.4 0.8 -0.1 0.9
Neuroticism (2016) 1.0 1.5 3.0 -1.7 -0.2
Primary Biliary Cirrhosis 0.1 0.1 0.3 0.0 -0.5
Rheumatoid Arthritis 1.1 1.5 1.9 -1.1 1.4
Schizophrenia (2014) 0.0 0.0 0.0 -0.1 -0.2
Triglycerides 0.1 0.2 0.5 0.7 0.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.2 0.5 -0.4
Ulcerative Colitis 0.6 0.9 1.1 1.1 0.8
Blood Eosinophil Count 0.0 0.2 0.3 -0.3 -0.5
Blood Platelet Count 3.4 39.0 47.5 -6.9 5.5
Blood Red Count 0.3 2.8 3.1 -1.8 1.6
Blood White Count 1.6 11.5 11.6 -3.4 3.4
Heel T-Score 0.1 0.6 0.9 0.5 0.9
BMI 0.3 1.5 1.6 -1.2 1.2
Height 1.3 26.0 31.9 -5.7 4.5
Waist Hip Ratio (WHR) 0.1 0.6 0.6 -0.8 -0.7
Systolic Blood Pressure 0.6 2.9 5.3 0.7 -2.3
Smoking Status 0.0 0.0 0.0 -0.1 -0.1
Allergy or Eczema 0.1 0.3 0.5 -0.2 0.7
Cardiovascular Disease 0.3 0.9 1.7 0.2 -1.3
Hypothyroidism (self reported) 0.0 0.1 0.1 0.3 0.2
Respiratory disease 0.9 1.9 2.4 -1.6 1.2
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.6 -0.3
Lung FEV1/FVC ratio 4.7 23.8 24.6 4.8 -5.0
Lung FVC 5.4 27.4 30.8 -4.9 5.5
Neuroticism 0.1 0.2 0.3 -0.3 0.5
Chronotype (morning person) 0.5 1.2 1.5 1.2 0.9
Hair Pigment 0.0 0.2 0.2 0.5 -0.4
Tanning 0.2 2.6 4.2 -1.0 2.0
Hand grip strength (left) 3.2 8.3 11.2 -2.3 3.4
Number of treatments/medications taken 0.7 1.3 1.5 -1.0 1.2
Average weekly spirits intake 1.3 1.7 2.6 -0.8 1.6
Sensitivity / hurt feelings 1.0 1.6 1.7 1.3 -1.3
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.0 1.0 -1.0
Hearing difficulty/problems: Yes 0.1 0.2 0.2 0.5 -0.3
Relative age of first facial hair 0.3 0.6 1.1 0.2 -1.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 0.8 -0.6 0.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.8 -0.3 -1.3
Ever had hysterectomy (womb removed) 0.1 0.2 0.2 0.5 -0.3
Systolic blood pressure, automated reading 0.0 0.1 0.2 -0.4 -0.3
Eye problems/disorders: Diabetes related eye disease 4.1 4.5 8.1 -2.8 1.0
Angina 0.4 0.6 0.7 0.7 -0.8
Medication for hormone replacement therapy 0.7 0.8 1.6 0.0 -1.2
Vitamin and mineral supplements 0.9 1.2 1.2 -1.1 1.1
Supplements: Zinc 1.0 1.0 1.1 1.0 -1.0
Medication: Co-codamol 0.1 0.1 0.2 0.1 -0.5
Medication: Metformin 0.3 0.4 0.4 -0.6 0.7
Diabetes (father) 1.8 2.2 2.9 -1.3 1.7
Diabetes (mother) 0.1 0.1 0.1 -0.4 -0.3
Severe depression (siblings) 1.5 1.7 1.8 -1.3 1.3
Pack years adult smoking proportion 0.2 0.4 0.7 0.2 -0.8
Impedance of leg (right) 0.1 0.5 0.8 0.4 -0.9
Leg fat-free mass (left) 1.2 6.6 7.0 -2.6 2.5
Trunk fat percentage 2.1 8.5 11.0 -3.3 2.5
Hand grip strength (right) 2.6 7.1 8.1 -2.5 2.9
Townsend deprivation index at recruitment 0.5 0.7 1.4 -0.2 1.2
Current tobacco smoking 2.5 4.0 4.8 2.2 -1.8
Average weekly fortified wine intake 1.6 1.8 2.3 -1.2 1.5
Maternal smoking around birth 1.7 2.5 4.2 -0.9 2.0
Fed-up feelings 0.1 0.2 0.4 0.2 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.2 0.8 -1.1
Relative age voice broke 0.2 0.3 0.4 0.5 -0.7
Taking other prescription medications 0.3 0.5 1.0 -1.0 0.0
Age when periods started (menarche) 1.2 2.9 3.1 1.8 -1.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.3 -0.6 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.6 -0.2 1.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.1 0.1 1.0
Qualifications: CSEs or equivalent 0.7 0.9 1.8 1.4 0.0
Serious illness, injury or assault to yourself 1.0 1.2 1.6 -0.9 1.3
High blood pressure 0.0 0.1 0.2 -0.2 -0.4
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.1 -0.6 1.0
Multivitamins +/- minerals 0.2 0.3 0.5 0.4 -0.7
Stomach or abdominal pain in last month 0.3 0.4 0.7 0.4 0.8
Supplements: Glucosamine 0.4 0.5 0.8 -0.9 0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.4 -0.0 -1.2
Medication: Atenolol 0.8 1.0 1.2 -1.1 -0.9
Medication: Levothyroxine sodium 0.5 0.8 0.9 -0.9 0.9
Sitting height 1.7 11.8 12.6 -3.3 3.5
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.2 0.0
High blood pressure (mother) 1.0 1.4 1.8 1.0 -1.3
Body mass index (BMI) 0.4 1.5 1.6 -1.2 1.3
Impedance of leg (left) 0.0 0.1 0.2 -0.4 -0.1
Leg predicted mass (left) 1.2 6.2 6.5 -2.5 2.4
Trunk fat mass 2.4 10.4 12.7 -3.6 2.8
Waist circumference 1.1 3.9 4.6 -2.1 1.8
Number of incorrect matches in round 0.1 0.2 0.4 -0.2 -0.6
Past tobacco smoking 1.7 3.2 4.6 2.1 -1.3
Alcohol usually taken with meals 1.8 2.9 3.3 -1.6 1.8
Nervous feelings 0.2 0.3 0.5 0.2 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.1 0.4 -1.5
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.4 0.2
Hair/balding pattern: Pattern 2 0.6 0.8 1.1 1.1 -0.6
Had menopause 1.1 1.4 2.5 -1.6 0.5
Had other major operations 0.0 0.1 0.1 0.3 0.2
Forced vital capacity (FVC) 8.9 34.3 34.9 -5.9 5.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 0.3 0.6
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.3 -0.6 -1.5
Qualifications: None of the above 0.7 1.4 2.0 0.9 -1.4
Financial difficulties in last 2 years 0.2 0.3 0.4 0.4 0.7
Mouth/teeth dental problems 5.8 8.9 10.7 -2.7 3.3
Heart attack 0.0 0.1 0.1 -0.1 0.3
Allergy 1.2 2.7 2.8 1.7 -1.6
Pain all over the body in last month 0.2 0.2 0.3 -0.2 0.6
Diabetes (self-reported) 0.5 0.8 1.6 -1.3 -0.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.2 -1.1 0.2
Medication: Ramipril 0.4 0.5 0.9 1.0 0.0
Medication: Simvastatin 0.3 0.5 0.9 -1.0 0.3
Fluid intelligence score 0.1 0.1 0.2 -0.2 0.4
Illnesses of siblings 0.2 0.3 0.5 0.7 0.4
Neuroticism score 0.0 0.0 0.1 -0.0 0.2
Weight 1.8 9.1 9.1 -3.0 3.0
Impedance of arm (right) 0.2 1.1 2.1 -1.4 -0.2
Arm fat percentage (right) 0.7 2.9 4.4 -2.1 1.2
Trunk fat-free mass 0.9 5.1 5.5 -2.2 2.4
Hip circumference 1.3 5.7 6.1 -2.5 2.3
Time employed in main current job 1.0 1.1 1.2 -1.1 1.0
Alcohol intake versus 10 years previously 0.0 0.0 0.0 0.0 0.2
Father’s age at death 1.5 2.0 2.9 -1.7 1.1
Worrier / anxious feelings 0.1 0.3 0.5 -0.2 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.1 -0.2 -0.2
Falls in the last year 0.2 0.3 0.5 0.7 0.0
Hair/balding pattern: Pattern 3 0.5 0.7 1.3 0.3 -1.1
Number of live births 0.7 1.0 2.0 0.2 -1.4
Forced expiratory volume in 1-second (FEV1) 4.4 14.7 16.2 -4.0 3.6
Pulse rate 3.1 5.2 8.3 -1.4 2.9
Happiness 1.3 1.6 2.5 0.8 -1.6
Noisy workplace 0.1 0.1 0.1 0.2 0.3
Qualifications: A levels/AS levels or equivalent 0.4 1.0 1.8 -0.4 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.4 -1.0 1.2
Mouth/teeth dental problems: Dentures 0.8 1.3 2.2 0.7 -1.5
Asthma 0.5 1.0 1.7 -0.6 1.3
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 4.2 -1.4 2.1
Medication: Cholesterol lowering 0.2 0.2 0.3 -0.6 0.4
Depression (self-reported) 0.1 0.1 0.1 0.3 -0.3
Medication: Lansoprazole 0.5 0.6 0.9 -0.4 1.0
Prospective memory result 0.8 1.0 1.9 -1.4 0.3
Lung cancer (father) 4.0 4.6 5.6 -1.9 2.4
Illnesses of mother 2.1 2.6 5.1 -2.3 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.4 9.7 -3.1 3.0
Pulse wave Arterial Stiffness index 0.8 1.0 1.3 1.2 -0.8
Impedance of arm (left) 0.2 1.0 2.1 -1.4 0.1
Arm fat mass (right) 1.0 4.2 5.5 -2.4 1.7
Trunk predicted mass 0.8 4.9 5.2 -2.1 2.3
Standing height 1.6 16.0 17.0 -4.1 3.9
Length of working week for main job 1.6 1.7 2.5 -1.0 1.6
Exposure to tobacco smoke at home 2.5 2.8 4.2 -2.1 1.1
Breastfed as a baby 0.9 1.1 1.5 -1.2 0.9
Tense / ‘highly strung’ 1.3 2.1 2.8 -1.7 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.4 -1.2 -0.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 0.6 0.3
Birth weight of first child 0.1 0.2 0.4 0.6 -0.2
Peak expiratory flow (PEF) 0.5 1.2 2.2 0.3 -1.5
Pulse wave reflection index 2.4 3.0 3.1 1.8 -1.7
Ever highly irritable/argumentative for 2 days 2.7 3.2 5.4 1.0 -2.3
Loud music exposure frequency 2.0 2.2 3.8 2.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.8 0.1 0.9
Mouth/teeth dental problems: Bleeding gums 3.6 4.7 6.0 1.8 -2.4
Blood clot in the leg (DVT) 1.9 2.4 4.8 -2.2 0.0
Medication: Paracetamol 1.2 2.0 2.8 -1.1 1.7
Headache pain in last month 0.8 1.4 2.1 -1.4 0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.5 0.7 -0.5
Glaucoma (self-reported) 0.0 0.0 0.0 -0.0 -0.1
Gout (self-reported) 0.4 0.6 1.1 -1.0 0.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.2 -0.6 1.1
Medication: Amlodipine 0.8 1.2 1.8 -0.7 -1.4
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 -0.5 1.2
Birth weight 0.4 0.8 1.6 -0.1 1.3
Chronic bronchitis/emphysema (mother) 0.8 1.0 1.4 1.2 0.8
High blood pressure (siblings) 0.2 0.3 0.5 -0.7 -0.4
Forced vital capacity (FVC), Best measure 7.2 26.4 28.3 -4.9 5.3
Body fat percentage 1.4 5.5 7.1 -2.7 2.0
Leg fat percentage (right) 0.5 1.8 2.0 -1.4 1.3
Arm fat-free mass (right) 0.8 4.2 5.9 -1.6 2.4
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.0 -0.6
Comparative body size at age 10 1.9 5.3 7.7 2.8 -1.7
Number of full brothers 1.1 1.4 2.8 -0.3 -1.7
Worry too long after embarrassment 0.2 0.3 0.6 -0.8 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.2 0.3 -1.1
Wheeze or whistling in the chest in last year 0.2 0.4 0.5 -0.6 0.7
Number of children fathered 0.5 0.6 1.0 -0.4 1.0
Reason for reducing amount of alcohol drunk: Health precaution 2.9 3.4 6.1 -0.8 2.5
Age at first live birth 0.6 1.1 1.7 0.7 -1.3
Pulse wave peak to peak time 1.2 1.4 1.9 -1.4 0.9
Health satisfaction 0.3 0.4 0.6 0.4 -0.8
Shortness of breath walking on level ground 0.9 1.1 2.0 0.5 -1.4
Qualifications: College or University degree 2.9 9.1 10.4 -3.2 2.8
Eye problems/disorders: None of the above 0.0 0.1 0.1 0.2 0.2
Mouth/teeth dental problems: Loose teeth 2.9 3.5 5.5 1.2 -2.3
Emphysema/chronic bronchitis 3.4 3.9 4.8 -2.2 1.7
Medication for pain relief, constipation, heartburn 1.2 2.0 2.2 1.5 -1.4
Neck or shoulder pain in last month 1.4 1.9 3.0 -1.7 0.9
Medication: Blood pressure 0.1 0.1 0.2 -0.4 0.2
Angina (self-reported) 0.6 0.7 0.8 0.8 -0.9
Migraine (self-reported) 0.3 0.3 0.6 -0.2 -0.8
Medication: Ibuprofen 4.1 4.9 5.3 -2.1 2.3
Medication: Allopurinol 0.0 0.0 0.0 -0.2 0.2
Medication: Omeprazole 0.0 0.0 0.0 0.1 0.1
Medication: Seretide 50 evohaler 0.3 0.4 0.7 0.2 -0.8
Mean time to correctly identify matches 2.0 3.9 6.8 1.0 -2.6
Heart disease (mother) 1.2 1.4 2.9 -0.0 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.2 -0.5 0.4
Whole body fat mass 1.7 7.0 8.9 -3.0 2.3
Leg fat mass (right) 0.8 3.1 3.8 -1.9 1.6
Arm predicted mass (right) 1.1 5.7 8.1 -1.8 2.8
Pulse rate, automated reading 3.9 12.8 13.4 -3.5 3.7
Alcohol intake frequency. 1.4 3.2 4.7 1.3 -2.2
Comparative height size at age 10 1.7 9.5 10.8 -3.3 2.9
Number of full sisters 0.3 0.3 0.5 -0.7 0.3
Suffer from ‘nerves’ 0.0 0.0 0.0 0.1 0.0
Overall health rating 0.0 0.1 0.1 -0.3 0.1
Chest pain or discomfort 0.1 0.2 0.4 -0.1 -0.6
Had major operations 2.4 2.8 4.0 -2.0 1.3
Age at last live birth 3.5 5.1 8.1 1.5 -2.8
Family relationship satisfaction 0.3 0.3 0.7 -0.1 -0.8
Leg pain on walking 0.3 0.3 0.5 -0.7 0.5
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.3 1.8 0.8 -1.4
Commuting to job workplace: Car/motor vehicle 0.5 0.5 0.7 -0.8 0.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 0.9 0.8 -0.9
Medication: Aspirin 0.4 0.6 1.0 0.4 -1.0
Supplements: Vitamin C 3.0 3.6 5.3 2.3 -1.4
Knee pain experienced in last month 2.4 3.7 4.9 -2.2 1.6
Hypertension (Self-reported) 0.2 0.6 1.1 0.1 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.3 3.8 4.1 -2.0 1.9
Illnesses of father: Heart disease 0.1 0.1 0.2 0.4 0.1
Illnesses of siblings: Diabetes 2.1 2.6 4.0 1.1 -2.0
Smoking status: Previous 2.7 4.0 6.1 -2.5 1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.8 -1.7 1.2
Whole body fat-free mass 1.1 6.5 7.0 -2.5 2.6
Leg fat-free mass (right) 1.5 8.0 8.1 -2.9 2.8
Arm fat percentage (left) 1.0 3.9 5.4 -2.3 1.6
Average weekly red wine intake 0.3 0.5 0.8 -0.3 0.9
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.1 0.3 0.4
Mood swings 0.3 0.5 0.8 0.4 0.9
Loneliness, isolation 0.3 0.4 0.8 0.9 -0.2
Long-standing illness, disability or infirmity 0.5 0.7 1.4 0.2 1.2
Ever had bowel cancer screening 0.1 0.1 0.2 -0.4 0.3
Diabetes diagnosed by doctor 0.4 0.6 1.1 -1.1 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.4 1.2 0.2
Friendships satisfaction 0.9 1.1 2.2 0.3 -1.5
Qualifications: nursing, teaching 1.0 1.6 2.5 -1.6 0.8
Commuting to job workplace: Walk 0.8 0.9 1.8 1.3 0.2
Eye problems/disorders: Cataract 1.6 1.8 2.2 1.5 -1.2
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 4.0 2.0 -1.0
Medication for cholesterol 0.7 1.1 1.1 -1.1 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 1.7 1.3 -1.3
Back pain experienced in last month 0.2 0.2 0.5 -0.1 0.7
Mineral and other dietary supplements 0.7 1.0 1.6 -0.6 1.2
Breast cancer (self-reported) 0.6 0.7 0.7 -0.9 0.8
Asthma (self-reported) 0.6 1.2 1.7 -0.8 1.3
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.2 0.7
Osteoarthritis (self-reported) 0.9 1.2 1.9 -0.7 1.4
Medication: Aspirin 0.3 0.4 0.4 0.6 -0.6
Medication: Gliclazide 0.0 0.0 0.1 -0.3 0.0
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 0.0 0.1
Smoking status: Current 1.5 2.3 2.6 1.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.5 -0.4 1.6
Whole body water mass 1.0 5.8 6.2 -2.3 2.5
Leg predicted mass (right) 1.5 8.1 8.1 -2.8 2.8
Arm fat mass (left) 1.0 4.2 5.2 -2.3 1.8
Number of self-reported non-cancer illnesses 0.9 1.6 2.7 -1.7 0.6
Average weekly champagne plus white wine intake 0.2 0.2 0.3 -0.5 0.4
Miserableness 0.1 0.2 0.3 0.5 -0.4
Guilty feelings 0.4 0.6 1.2 -1.1 0.1
Wears glasses or contact lenses 0.2 0.2 0.3 -0.4 0.6
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.3 0.4
Hearing aid user 0.2 0.2 0.3 0.4 -0.5
Mother’s age at death 1.6 1.9 3.7 1.9 -0.4
Financial situation satisfaction 0.5 0.6 1.1 -0.2 -1.1
Tinnitus: Yes, now most or all of the time 2.8 3.3 6.3 -2.5 0.5
Commuting to job workplace: Public transport 0.4 0.4 0.6 -0.8 0.5
Eye problems/disorders: Glaucoma 0.0 0.1 0.1 -0.3 0.2
Medication: Blood pressure 1.1 2.1 2.2 1.4 -1.5
Pain type(s) experienced in last month: Hip pain 0.8 0.9 1.2 -0.8 1.1
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.4 0.6 -0.6
High cholesterol (Self-reported) 0.6 1.0 1.4 -0.8 1.2
Medication: Bendroflumethiazide 0.6 0.9 1.5 1.2 -0.6
Medication: Paracetamol 3.3 5.1 5.8 -2.1 2.4
Medication: Lisinopril 0.0 0.1 0.1 0.1 -0.3
Medication: Atorvastatin 1.7 2.2 4.2 2.0 -0.4
Illnesses of father: High blood pressure 2.8 3.4 3.8 1.8 -1.9
Alcohol drinker status: Never 0.2 0.2 0.4 -0.2 -0.6
Ever smoked 0.6 1.1 1.9 -1.4 0.5
Basal metabolic rate 1.4 7.5 7.7 -2.7 2.8
Leg fat percentage (left) 0.8 2.8 3.1 -1.8 1.6
Arm fat-free mass (left) 1.0 4.9 6.4 -1.9 2.5
Number of operations (self-reported) 0.1 0.1 0.2 -0.4 -0.3
Average weekly beer plus cider intake 0.2 0.4 0.4 -0.6 0.6
Irritability 0.4 0.7 1.1 -0.6 1.0
Risk taking 0.5 0.7 1.4 1.2 -0.1
Ever had prostate specific antigen (PSA) test 1.6 1.8 2.6 -1.1 1.6
Fractured/broken bones in last 5 years 0.2 0.3 0.5 0.1 -0.7
Age started oral contraceptive pill 1.3 1.7 2.9 -1.7 0.7
Diastolic blood pressure, automated reading 0.7 2.1 3.4 0.9 -1.8
Ever depressed for a whole week 3.2 3.9 7.2 0.8 -2.7
Unable to work because of sickness or disability 0.6 0.8 1.2 1.1 -0.6
Commuting to job workplace: Cycle 1.2 1.4 2.2 0.8 -1.5
Myopia 0.7 1.0 2.0 1.4 -0.1
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.4 -0.3 0.6
Cholesterol lowering medication 0.2 0.3 0.4 -0.4 0.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.3 -0.0 0.6
Pain experienced in last month 1.1 1.9 2.9 1.7 -1.0
Supplements: Calcium 0.5 0.5 1.0 -0.2 1.0
Basal cell carcinoma (self-reported) 1.6 1.9 2.9 1.7 -0.9
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 -0.1 0.1
Deep venous thrombosis (DVT) (self-reported) 1.9 2.5 4.9 -2.2 0.1
Heart disease (siblings) 0.1 0.2 0.3 0.5 0.2
Alcohol drinker status: Previous 0.2 0.2 0.3 0.5 -0.4
Pack years of smoking 0.3 0.4 0.7 -0.2 -0.8
Impedance of whole body 0.1 0.3 0.5 -0.7 0.0
Leg fat mass (left) 1.1 4.3 5.3 -2.3 1.8
Arm predicted mass (left) 0.8 4.2 5.4 -1.7 2.3