TWAS hub - LMCD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0797	0.0299	3.7e-05	0.001	0.039	0.039	NA	0.016	0.2700	2.9e-05	3.3e-05	NA	0.00520
2	TCGA	Skin Cutaneous Melanoma	0.1720	0.0930	4.3e-03	0.099	0.027	0.134	NA	0.128	0.0013	6.5e-02	2.0e-04	NA	0.00027

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced vital capacity (FVC)	8.9	34.3	34.9	-5.9	5.8
Forced vital capacity (FVC), Best measure	7.2	26.4	28.3	-4.9	5.3
Mouth/teeth dental problems	5.8	8.9	10.7	-2.7	3.3
Lung FVC	5.4	27.4	30.8	-4.9	5.5
Lung FEV1/FVC ratio	4.7	23.8	24.6	4.8	-5.0
Forced expiratory volume in 1-second (FEV1)	4.4	14.7	16.2	-4.0	3.6
Body Mass Index (BMI) (2010)	4.2	5.8	7.6	-2.0	2.8
Eye problems/disorders: Diabetes related eye disease	4.1	4.5	8.1	-2.8	1.0
Medication: Ibuprofen	4.1	4.9	5.3	-2.1	2.3
Lung cancer (father)	4.0	4.6	5.6	-1.9	2.4
Pulse rate, automated reading	3.9	12.8	13.4	-3.5	3.7
Mouth/teeth dental problems: Bleeding gums	3.6	4.7	6.0	1.8	-2.4
Age at last live birth	3.5	5.1	8.1	1.5	-2.8
Blood Platelet Count	3.4	39.0	47.5	-6.9	5.5
Emphysema/chronic bronchitis	3.4	3.9	4.8	-2.2	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.8	4.1	-2.0	1.9
Medication: Paracetamol	3.3	5.1	5.8	-2.1	2.4
Hand grip strength (left)	3.2	8.3	11.2	-2.3	3.4
Ever depressed for a whole week	3.2	3.9	7.2	0.8	-2.7
Pulse rate	3.1	5.2	8.3	-1.4	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.4	9.7	-3.1	3.0
Supplements: Vitamin C	3.0	3.6	5.3	2.3	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	6.1	-0.8	2.5
Qualifications: College or University degree	2.9	9.1	10.4	-3.2	2.8
Mouth/teeth dental problems: Loose teeth	2.9	3.5	5.5	1.2	-2.3
Tinnitus: Yes, now most or all of the time	2.8	3.3	6.3	-2.5	0.5
Illnesses of father: High blood pressure	2.8	3.4	3.8	1.8	-1.9
Ever highly irritable/argumentative for 2 days	2.7	3.2	5.4	1.0	-2.3
Smoking status: Previous	2.7	4.0	6.1	-2.5	1.4
Hand grip strength (right)	2.6	7.1	8.1	-2.5	2.9
Reaction Time	2.5	4.8	7.8	1.4	-2.8
Bipolar Disorder (2011)	2.5	2.4	4.3	0.7	-2.1
Current tobacco smoking	2.5	4.0	4.8	2.2	-1.8
Exposure to tobacco smoke at home	2.5	2.8	4.2	-2.1	1.1
Trunk fat mass	2.4	10.4	12.7	-3.6	2.8
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	4.2	-1.4	2.1
Pulse wave reflection index	2.4	3.0	3.1	1.8	-1.7
Had major operations	2.4	2.8	4.0	-2.0	1.3
Knee pain experienced in last month	2.4	3.7	4.9	-2.2	1.6
Depression (Nagel 2018)	2.1	3.2	4.2	1.5	-2.1
Trunk fat percentage	2.1	8.5	11.0	-3.3	2.5
Illnesses of mother	2.1	2.6	5.1	-2.3	0.2
Illnesses of siblings: Diabetes	2.1	2.6	4.0	1.1	-2.0
Loud music exposure frequency	2.0	2.2	3.8	2.0	-0.8
Mean time to correctly identify matches	2.0	3.9	6.8	1.0	-2.6
Blood clot in the leg (DVT)	1.9	2.4	4.8	-2.2	0.0
Comparative body size at age 10	1.9	5.3	7.7	2.8	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.9	-2.2	0.1
Diabetes (father)	1.8	2.2	2.9	-1.3	1.7
Alcohol usually taken with meals	1.8	2.9	3.3	-1.6	1.8
Weight	1.8	9.1	9.1	-3.0	3.0
Schizophrenia vs Biploar Disorder	1.7	2.3	4.4	-2.1	0.3
Breast Cancer	1.7	4.0	4.6	1.9	-2.1
Maternal smoking around birth	1.7	2.5	4.2	-0.9	2.0
Sitting height	1.7	11.8	12.6	-3.3	3.5
Past tobacco smoking	1.7	3.2	4.6	2.1	-1.3
Whole body fat mass	1.7	7.0	8.9	-3.0	2.3
Comparative height size at age 10	1.7	9.5	10.8	-3.3	2.9
Medication: Atorvastatin	1.7	2.2	4.2	2.0	-0.4
Mean Putamen Volume	1.6	1.8	2.5	1.0	-1.6
Blood White Count	1.6	11.5	11.6	-3.4	3.4
Average weekly fortified wine intake	1.6	1.8	2.3	-1.2	1.5
Standing height	1.6	16.0	17.0	-4.1	3.9
Length of working week for main job	1.6	1.7	2.5	-1.0	1.6
Eye problems/disorders: Cataract	1.6	1.8	2.2	1.5	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	4.0	2.0	-1.0
Mother’s age at death	1.6	1.9	3.7	1.9	-0.4
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.6	-1.1	1.6
Basal cell carcinoma (self-reported)	1.6	1.9	2.9	1.7	-0.9
Severe depression (siblings)	1.5	1.7	1.8	-1.3	1.3
Father’s age at death	1.5	2.0	2.9	-1.7	1.1
Leg fat-free mass (right)	1.5	8.0	8.1	-2.9	2.8
Smoking status: Current	1.5	2.3	2.6	1.6	-1.4
Leg predicted mass (right)	1.5	8.1	8.1	-2.8	2.8
Body fat percentage	1.4	5.5	7.1	-2.7	2.0
Neck or shoulder pain in last month	1.4	1.9	3.0	-1.7	0.9
Alcohol intake frequency.	1.4	3.2	4.7	1.3	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	1.7	1.3	-1.3
Basal metabolic rate	1.4	7.5	7.7	-2.7	2.8
Height	1.3	26.0	31.9	-5.7	4.5
Average weekly spirits intake	1.3	1.7	2.6	-0.8	1.6
Hip circumference	1.3	5.7	6.1	-2.5	2.3
Happiness	1.3	1.6	2.5	0.8	-1.6
Tense / ‘highly strung’	1.3	2.1	2.8	-1.7	1.2
Age started oral contraceptive pill	1.3	1.7	2.9	-1.7	0.7
Alzheimer’s Disease (in father)	1.2	1.3	1.9	-0.8	1.4
Leg fat-free mass (left)	1.2	6.6	7.0	-2.6	2.5
Age when periods started (menarche)	1.2	2.9	3.1	1.8	-1.6
Leg predicted mass (left)	1.2	6.2	6.5	-2.5	2.4
Allergy	1.2	2.7	2.8	1.7	-1.6
Medication: Paracetamol	1.2	2.0	2.8	-1.1	1.7
Pulse wave peak to peak time	1.2	1.4	1.9	-1.4	0.9
Medication for pain relief, constipation, heartburn	1.2	2.0	2.2	1.5	-1.4
Heart disease (mother)	1.2	1.4	2.9	-0.0	1.7
Commuting to job workplace: Cycle	1.2	1.4	2.2	0.8	-1.5
Rheumatoid Arthritis	1.1	1.5	1.9	-1.1	1.4
Waist circumference	1.1	3.9	4.6	-2.1	1.8
Had menopause	1.1	1.4	2.5	-1.6	0.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.3	-0.6	-1.5
Number of full brothers	1.1	1.4	2.8	-0.3	-1.7
Arm predicted mass (right)	1.1	5.7	8.1	-1.8	2.8
Whole body fat-free mass	1.1	6.5	7.0	-2.5	2.6
Medication: Blood pressure	1.1	2.1	2.2	1.4	-1.5
Pain experienced in last month	1.1	1.9	2.9	1.7	-1.0
Leg fat mass (left)	1.1	4.3	5.3	-2.3	1.8
Alzheimer’s Disease (including proxy)	1.0	1.5	2.0	-1.0	1.4
Neuroticism (2016)	1.0	1.5	3.0	-1.7	-0.2
Sensitivity / hurt feelings	1.0	1.6	1.7	1.3	-1.3
Supplements: Zinc	1.0	1.0	1.1	1.0	-1.0
Serious illness, injury or assault to yourself	1.0	1.2	1.6	-0.9	1.3
High blood pressure (mother)	1.0	1.4	1.8	1.0	-1.3
Time employed in main current job	1.0	1.1	1.2	-1.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.4	-1.0	1.2
Arm fat mass (right)	1.0	4.2	5.5	-2.4	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	1.8	0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.8	-1.7	1.2
Arm fat percentage (left)	1.0	3.9	5.4	-2.3	1.6
Qualifications: nursing, teaching	1.0	1.6	2.5	-1.6	0.8
Whole body water mass	1.0	5.8	6.2	-2.3	2.5
Arm fat mass (left)	1.0	4.2	5.2	-2.3	1.8
Arm fat-free mass (left)	1.0	4.9	6.4	-1.9	2.5
Bipolar Disorder (2018)	0.9	1.4	2.3	1.5	-0.7
Major Depression (MDD)	0.9	1.1	1.7	1.3	-0.8
Respiratory disease	0.9	1.9	2.4	-1.6	1.2
Vitamin and mineral supplements	0.9	1.2	1.2	-1.1	1.1
Trunk fat-free mass	0.9	5.1	5.5	-2.2	2.4
Breastfed as a baby	0.9	1.1	1.5	-1.2	0.9
Shortness of breath walking on level ground	0.9	1.1	2.0	0.5	-1.4
Friendships satisfaction	0.9	1.1	2.2	0.3	-1.5
Osteoarthritis (self-reported)	0.9	1.2	1.9	-0.7	1.4
Number of self-reported non-cancer illnesses	0.9	1.6	2.7	-1.7	0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	2.2	-1.5	1.2
Medication: Atenolol	0.8	1.0	1.2	-1.1	-0.9
Mouth/teeth dental problems: Dentures	0.8	1.3	2.2	0.7	-1.5
Prospective memory result	0.8	1.0	1.9	-1.4	0.3
Pulse wave Arterial Stiffness index	0.8	1.0	1.3	1.2	-0.8
Trunk predicted mass	0.8	4.9	5.2	-2.1	2.3
Headache pain in last month	0.8	1.4	2.1	-1.4	0.8
Medication: Amlodipine	0.8	1.2	1.8	-0.7	-1.4
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.4	1.2	0.8
Arm fat-free mass (right)	0.8	4.2	5.9	-1.6	2.4
Leg fat mass (right)	0.8	3.1	3.8	-1.9	1.6
Commuting to job workplace: Walk	0.8	0.9	1.8	1.3	0.2
Pain type(s) experienced in last month: Hip pain	0.8	0.9	1.2	-0.8	1.1
Leg fat percentage (left)	0.8	2.8	3.1	-1.8	1.6
Arm predicted mass (left)	0.8	4.2	5.4	-1.7	2.3
Number of treatments/medications taken	0.7	1.3	1.5	-1.0	1.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.0	1.0	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	-0.3	-1.3
Medication for hormone replacement therapy	0.7	0.8	1.6	0.0	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.2	0.8	-1.1
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.1	0.4	-1.5
Qualifications: None of the above	0.7	1.4	2.0	0.9	-1.4
Arm fat percentage (right)	0.7	2.9	4.4	-2.1	1.2
Number of live births	0.7	1.0	2.0	0.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.4	1.2	0.2
Medication for cholesterol	0.7	1.1	1.1	-1.1	1.0
Mineral and other dietary supplements	0.7	1.0	1.6	-0.6	1.2
Diastolic blood pressure, automated reading	0.7	2.1	3.4	0.9	-1.8
Myopia	0.7	1.0	2.0	1.4	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.2	-1.8	0.6
Ulcerative Colitis	0.6	0.9	1.1	1.1	0.8
Systolic Blood Pressure	0.6	2.9	5.3	0.7	-2.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-0.0	-1.2
Hair/balding pattern: Pattern 2	0.6	0.8	1.1	1.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	-0.5	1.2
Age at first live birth	0.6	1.1	1.7	0.7	-1.3
Angina (self-reported)	0.6	0.7	0.8	0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	0.9	0.8	-0.9
Breast cancer (self-reported)	0.6	0.7	0.7	-0.9	0.8
Asthma (self-reported)	0.6	1.2	1.7	-0.8	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.5	-0.4	1.6
High cholesterol (Self-reported)	0.6	1.0	1.4	-0.8	1.2
Medication: Bendroflumethiazide	0.6	0.9	1.5	1.2	-0.6
Ever smoked	0.6	1.1	1.9	-1.4	0.5
Unable to work because of sickness or disability	0.6	0.8	1.2	1.1	-0.6
Worry (Nagel 2018)	0.5	1.0	2.0	-0.0	-1.4
Ulcerative Colitis (UC)	0.5	0.9	1.0	0.9	1.0
HbA1C	0.5	0.5	0.6	-0.8	0.7
Chronotype (morning person)	0.5	1.2	1.5	1.2	0.9
Townsend deprivation index at recruitment	0.5	0.7	1.4	-0.2	1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.1	0.1	1.0
Medication: Levothyroxine sodium	0.5	0.8	0.9	-0.9	0.9
Diabetes (self-reported)	0.5	0.8	1.6	-1.3	-0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.2	-1.1	0.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	0.3	-1.1
Asthma	0.5	1.0	1.7	-0.6	1.3
Medication: Lansoprazole	0.5	0.6	0.9	-0.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	-1.2	-0.4
Peak expiratory flow (PEF)	0.5	1.2	2.2	0.3	-1.5
Leg fat percentage (right)	0.5	1.8	2.0	-1.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.2	0.3	-1.1
Number of children fathered	0.5	0.6	1.0	-0.4	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.7	-0.8	0.6
Long-standing illness, disability or infirmity	0.5	0.7	1.4	0.2	1.2
Financial situation satisfaction	0.5	0.6	1.1	-0.2	-1.1
Risk taking	0.5	0.7	1.4	1.2	-0.1
Supplements: Calcium	0.5	0.5	1.0	-0.2	1.0
Fasting Glucose	0.4	0.5	0.7	-0.8	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.8	-0.6	0.9
Angina	0.4	0.6	0.7	0.7	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.6	-0.2	1.3
Supplements: Glucosamine	0.4	0.5	0.8	-0.9	0.4
Body mass index (BMI)	0.4	1.5	1.6	-1.2	1.3
Medication: Ramipril	0.4	0.5	0.9	1.0	0.0
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.8	-0.4	1.4
Gout (self-reported)	0.4	0.6	1.1	-1.0	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.2	-0.6	1.1
Birth weight	0.4	0.8	1.6	-0.1	1.3
Medication: Aspirin	0.4	0.6	1.0	0.4	-1.0
Diabetes diagnosed by doctor	0.4	0.6	1.1	-1.1	0.4
Guilty feelings	0.4	0.6	1.2	-1.1	0.1
Commuting to job workplace: Public transport	0.4	0.4	0.6	-0.8	0.5
Irritability	0.4	0.7	1.1	-0.6	1.0
Bipolar Disorder or Schizophrenia	0.3	0.7	0.9	0.9	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.3	0.2	-1.1
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.3	-0.8
Lupus	0.3	0.4	0.8	-0.1	0.9
Blood Red Count	0.3	2.8	3.1	-1.8	1.6
BMI	0.3	1.5	1.6	-1.2	1.2
Cardiovascular Disease	0.3	0.9	1.7	0.2	-1.3
Relative age of first facial hair	0.3	0.6	1.1	0.2	-1.1
Medication: Metformin	0.3	0.4	0.4	-0.6	0.7
Taking other prescription medications	0.3	0.5	1.0	-1.0	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.1	-0.6	1.0
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.4	0.8
Medication: Simvastatin	0.3	0.5	0.9	-1.0	0.3
Health satisfaction	0.3	0.4	0.6	0.4	-0.8
Migraine (self-reported)	0.3	0.3	0.6	-0.2	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.7	0.2	-0.8
Number of full sisters	0.3	0.3	0.5	-0.7	0.3
Family relationship satisfaction	0.3	0.3	0.7	-0.1	-0.8
Leg pain on walking	0.3	0.3	0.5	-0.7	0.5
Average weekly red wine intake	0.3	0.5	0.8	-0.3	0.9
Mood swings	0.3	0.5	0.8	0.4	0.9
Loneliness, isolation	0.3	0.4	0.8	0.9	-0.2
Medication: Aspirin	0.3	0.4	0.4	0.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.4	0.6	-0.6
Pack years of smoking	0.3	0.4	0.7	-0.2	-0.8
Irritable Bowel Disease (IBD)	0.2	0.5	0.6	0.6	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.2	0.5	-0.4
Tanning	0.2	2.6	4.2	-1.0	2.0
Pack years adult smoking proportion	0.2	0.4	0.7	0.2	-0.8
Relative age voice broke	0.2	0.3	0.4	0.5	-0.7
Multivitamins +/- minerals	0.2	0.3	0.5	0.4	-0.7
Nervous feelings	0.2	0.3	0.5	0.2	-0.7
Financial difficulties in last 2 years	0.2	0.3	0.4	0.4	0.7
Pain all over the body in last month	0.2	0.2	0.3	-0.2	0.6
Illnesses of siblings	0.2	0.3	0.5	0.7	0.4
Impedance of arm (right)	0.2	1.1	2.1	-1.4	-0.2
Falls in the last year	0.2	0.3	0.5	0.7	0.0
Medication: Cholesterol lowering	0.2	0.2	0.3	-0.6	0.4
Impedance of arm (left)	0.2	1.0	2.1	-1.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	0.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.5	0.7	-0.5
High blood pressure (siblings)	0.2	0.3	0.5	-0.7	-0.4
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.0	-0.6
Worry too long after embarrassment	0.2	0.3	0.6	-0.8	0.2
Wheeze or whistling in the chest in last year	0.2	0.4	0.5	-0.6	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	-0.5	0.4
Hypertension (Self-reported)	0.2	0.6	1.1	0.1	-1.1
Back pain experienced in last month	0.2	0.2	0.5	-0.1	0.7
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.2	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.3	-0.5	0.4
Wears glasses or contact lenses	0.2	0.2	0.3	-0.4	0.6
Hearing aid user	0.2	0.2	0.3	0.4	-0.5
Alcohol drinker status: Never	0.2	0.2	0.4	-0.2	-0.6
Average weekly beer plus cider intake	0.2	0.4	0.4	-0.6	0.6
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.1	-0.7
Cholesterol lowering medication	0.2	0.3	0.4	-0.4	0.6
Alcohol drinker status: Previous	0.2	0.2	0.3	0.5	-0.4
Ovarian Cancer	0.1	0.1	0.2	0.5	0.2
Age at First Birth	0.1	0.2	0.3	0.6	0.3
LDL Cholesterol	0.1	0.2	0.3	-0.2	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.0	-0.5
Triglycerides	0.1	0.2	0.5	0.7	0.0
Heel T-Score	0.1	0.6	0.9	0.5	0.9
Waist Hip Ratio (WHR)	0.1	0.6	0.6	-0.8	-0.7
Allergy or Eczema	0.1	0.3	0.5	-0.2	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	-0.3
Neuroticism	0.1	0.2	0.3	-0.3	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.2	0.5	-0.3
Ever had hysterectomy (womb removed)	0.1	0.2	0.2	0.5	-0.3
Medication: Co-codamol	0.1	0.1	0.2	0.1	-0.5
Diabetes (mother)	0.1	0.1	0.1	-0.4	-0.3
Impedance of leg (right)	0.1	0.5	0.8	0.4	-0.9
Fed-up feelings	0.1	0.2	0.4	0.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.6	-0.1
Number of incorrect matches in round	0.1	0.2	0.4	-0.2	-0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.3	0.6
Fluid intelligence score	0.1	0.1	0.2	-0.2	0.4
Worrier / anxious feelings	0.1	0.3	0.5	-0.2	-0.7
Noisy workplace	0.1	0.1	0.1	0.2	0.3
Depression (self-reported)	0.1	0.1	0.1	0.3	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.6	0.3
Birth weight of first child	0.1	0.2	0.4	0.6	-0.2
Medication: Blood pressure	0.1	0.1	0.2	-0.4	0.2
Chest pain or discomfort	0.1	0.2	0.4	-0.1	-0.6
Illnesses of father: Heart disease	0.1	0.1	0.2	0.4	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.3	0.4
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	0.3
Miserableness	0.1	0.2	0.3	0.5	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.3	0.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.3	0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	-0.0	0.6
Heart disease (siblings)	0.1	0.2	0.3	0.5	0.2
Impedance of whole body	0.1	0.3	0.5	-0.7	0.0
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.3	-0.2
Schizophrenia (2018)	0.0	0.0	0.1	0.1	-0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.2	-0.1
Crohns Disease (2017)	0.0	0.0	0.0	-0.1	0.2
Prostate Cancer	0.0	0.0	0.0	0.2	0.1
Crohns Disease (2012)	0.0	0.1	0.1	0.2	-0.3
HDL Cholesterol	0.0	0.0	0.1	0.3	0.1
Schizophrenia (2014)	0.0	0.0	0.0	-0.1	-0.2
Blood Eosinophil Count	0.0	0.2	0.3	-0.3	-0.5
Smoking Status	0.0	0.0	0.0	-0.1	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.1	0.3	0.2
Hair Pigment	0.0	0.2	0.2	0.5	-0.4
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.4	-0.3
High blood pressure	0.0	0.1	0.2	-0.2	-0.4
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.2	0.0
Impedance of leg (left)	0.0	0.1	0.2	-0.4	-0.1
Had other major operations	0.0	0.1	0.1	0.3	0.2
Heart attack	0.0	0.1	0.1	-0.1	0.3
Neuroticism score	0.0	0.0	0.1	-0.0	0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.2	-0.2
Glaucoma (self-reported)	0.0	0.0	0.0	-0.0	-0.1
Eye problems/disorders: None of the above	0.0	0.1	0.1	0.2	0.2
Medication: Allopurinol	0.0	0.0	0.0	-0.2	0.2
Medication: Omeprazole	0.0	0.0	0.0	0.1	0.1
Suffer from ‘nerves’	0.0	0.0	0.0	0.1	0.0
Overall health rating	0.0	0.1	0.1	-0.3	0.1
Medication: Gliclazide	0.0	0.0	0.1	-0.3	0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	0.0	0.1
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	-0.3	0.2
Medication: Lisinopril	0.0	0.1	0.1	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	0.1

Hub : Genes

LMCD1

Models

Trait associations