TWAS hub - LMF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2190	0.0710	3.7e-04	0.063	NA	0.036	NA	0.028	2.2e-04	NA	4.7e-03	NA	1.1e-02
2	GTEx	Brain Cerebellar Hemisphere	0.3680	0.0930	3.5e-05	0.156	NA	0.265	NA	0.258	8.1e-05	NA	1.7e-07	NA	2.7e-07
3	GTEx	Brain Cerebellum	0.1710	0.0650	2.6e-03	0.095	NA	0.137	NA	0.104	9.4e-04	NA	7.5e-05	NA	5.5e-04
4	GTEx	Brain Cortex	0.3320	0.1060	1.4e-03	0.120	NA	0.050	NA	0.123	3.4e-04	NA	1.7e-02	NA	2.9e-04
5	GTEx	Cells EBV-transformed lymphocytes	0.2170	0.0740	1.5e-03	0.159	NA	0.240	NA	0.235	7.0e-06	NA	2.2e-08	NA	3.2e-08
6	GTEx	Cells Transformed fibroblasts	0.3630	0.0600	1.5e-11	0.233	NA	0.280	NA	0.272	2.1e-17	NA	3.6e-21	NA	1.6e-20
7	GTEx	Esophagus Mucosa	0.2200	0.0770	4.0e-03	0.052	NA	0.082	NA	0.111	2.1e-04	NA	3.7e-06	NA	7.0e-08
8	GTEx	Heart Atrial Appendage	0.1890	0.0650	7.0e-04	0.128	NA	0.123	NA	0.115	2.4e-06	NA	3.8e-06	NA	7.6e-06
9	GTEx	Heart Left Ventricle	0.1552	0.0539	4.4e-04	0.078	NA	0.097	NA	0.101	5.9e-05	NA	7.5e-06	NA	5.2e-06
10	GTEx	Lung	0.1567	0.0531	4.0e-04	0.111	NA	0.086	NA	0.103	7.4e-09	NA	3.7e-07	NA	3.0e-08
11	GTEx	Muscle Skeletal	0.0999	0.0279	3.3e-06	0.097	NA	0.059	NA	0.078	8.9e-10	NA	1.8e-06	NA	3.9e-08
12	GTEx	Prostate	0.3130	0.1110	3.7e-03	0.063	NA	0.001	NA	0.058	1.1e-02	NA	3.0e-01	NA	1.4e-02
13	GTEx	Testis	0.1790	0.0740	2.6e-03	0.067	NA	0.006	NA	0.035	6.2e-04	NA	1.7e-01	NA	1.1e-02
14	GTEx	Thyroid	0.1550	0.0450	3.8e-05	0.141	NA	0.125	NA	0.133	5.9e-11	NA	8.3e-10	NA	2.3e-10
15	GTEx	Vagina	0.4160	0.1160	1.5e-03	-0.011	NA	0.000	NA	-0.010	6.8e-01	NA	3.3e-01	NA	6.3e-01
16	ROSMAP	Brain Pre-frontal Cortex	0.2794	0.0407	0.0e+00	0.257	0.295	0.327	0.319	0.321	8.3e-33	3.0e-38	4.3e-43	6.2e-42	3.6e-42
17	TCGA	Colon Adenocarcinoma	0.1000	0.0450	1.2e-03	0.021	0.032	0.027	NA	0.019	2.2e-02	6.1e-03	1.1e-02	NA	2.8e-02
18	TCGA	Head and Neck Squamous Cell Carcinoma	0.1172	0.0370	6.4e-08	0.064	0.078	0.070	NA	0.082	1.1e-07	4.5e-09	2.5e-08	NA	1.8e-09
19	TCGA	Kidney Renal Clear Cell Carcinoma	0.1703	0.0448	2.0e-07	0.065	0.086	0.061	NA	0.059	8.8e-08	6.0e-10	2.0e-07	NA	3.5e-07
20	TCGA	Brain Lower Grade Glioma	0.1541	0.0422	0.0e+00	0.192	0.171	0.176	NA	0.191	2.6e-21	4.9e-19	1.5e-19	NA	2.9e-21
21	TCGA	Lung Adenocarcinoma	0.1585	0.0448	1.1e-05	0.039	0.062	0.059	NA	0.040	2.0e-05	9.9e-08	1.8e-07	NA	1.7e-05
22	TCGA	Pheochromocytoma and Paraganglioma	0.1090	0.0610	1.0e-03	0.102	0.083	0.070	NA	0.090	7.4e-05	3.5e-04	9.5e-04	NA	2.0e-04
23	TCGA	Prostate Adenocarcinoma	0.1235	0.0414	3.1e-05	0.068	0.048	0.050	NA	0.056	1.3e-07	8.3e-06	5.3e-06	NA	1.5e-06
24	TCGA	Testicular Germ Cell Tumors	0.1360	0.0740	6.4e-03	0.036	0.032	-0.008	NA	0.010	2.1e-02	2.7e-02	9.3e-01	NA	1.4e-01
25	TCGA	Thyroid Carcinoma	0.1540	0.0460	1.1e-09	0.087	0.105	0.105	NA	0.111	8.1e-09	2.0e-10	2.0e-10	NA	5.9e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25
Comparative height size at age 10	7.7	42.4	70.9	6.3	-8.4	-8.1	5.0	7.0	5.9	6.6	7.3	7.3	5.1	8.4	8.4	4.9	6.4	3.6	5.9	6.9	6.9	2.6	6.1	2.4	7.9	5.9	7.4	7.0
Illnesses of siblings: Diabetes	7.7	9.5	14.7	2.7	-3.3	-3.5	1.8	3.2	2.3	3.4	3.3	3.8	3.4	2.9	3.2	3.3	3.5	3.8	3.0	1.9	3.7	1.8	2.5	1.5	3.4	3.5	2.4	3.8
Arm fat-free mass (right)	7.2	36.7	56.1	6.5	-7.3	-7.5	6.0	6.3	5.5	5.5	6.6	6.9	5.2	7.5	7.3	5.1	6.0	3.5	6.7	6.2	6.1	2.6	6.6	2.9	6.9	5.6	5.5	6.3
Arm predicted mass (right)	7.1	36.4	53.6	6.8	-7.1	-7.3	5.8	6.4	5.6	5.6	6.5	6.9	5.3	7.3	7.2	5.2	6.1	3.5	6.5	6.1	6.1	2.8	6.4	3.2	6.7	5.7	5.3	6.3
Arm fat-free mass (left)	6.9	35.2	51.6	6.4	-6.8	-7.1	6.0	6.2	5.3	5.4	6.5	6.8	5.4	7.2	7.0	5.2	6.0	4.0	6.7	6.1	6.0	2.6	6.6	3.1	6.3	5.6	5.1	6.3
Arm predicted mass (left)	6.3	31.8	47.2	6.3	-6.5	-6.8	5.8	5.9	5.0	5.1	6.1	6.5	5.0	6.9	6.7	4.8	5.7	3.7	6.3	5.7	5.7	2.3	6.3	2.7	6.2	5.3	5.0	5.9
Intelligence (Savage-Jansen 2018)	5.7	17.5	26.6	-4.2	3.6	4.0	-2.1	-4.6	-5.2	-4.6	-4.3	-4.7	-4.8	-3.9	-4.2	-5.0	-4.9	-3.4	-3.0	-5.1	-4.5	-4.3	-2.8	-3.5	-3.0	-4.8	-3.5	-4.5
Trunk predicted mass	5.6	31.9	49.6	6.0	-6.6	-6.8	5.8	5.8	4.9	5.2	6.2	6.5	5.0	7.0	6.8	4.8	5.7	3.3	6.2	6.0	5.7	2.5	6.2	3.0	6.1	5.3	4.9	6.0
Average weekly beer plus cider intake	5.6	8.1	11.7	3.0	-3.2	-3.0	1.0	3.3	3.1	3.4	2.9	3.3	2.9	2.8	3.1	2.9	3.2	1.9	1.8	3.0	3.4	2.7	1.7	1.4	3.4	3.2	2.1	3.3
Trunk fat-free mass	5.5	31.3	48.7	5.9	-6.5	-6.8	5.7	5.8	4.9	5.1	6.1	6.4	5.0	7.0	6.8	4.8	5.7	3.2	6.1	6.0	5.7	2.5	6.2	2.9	6.0	5.3	4.8	5.9
Whole body fat-free mass	5.1	29.1	43.8	5.8	-6.4	-6.5	5.3	5.6	4.8	5.0	5.8	6.2	4.8	6.6	6.5	4.7	5.5	2.9	5.8	5.8	5.5	2.7	5.8	2.8	5.9	5.1	4.8	5.7
Type 2 Diabetes (T2D) (2018)	4.9	9.3	13.9	1.3	-2.2	-2.7	2.6	3.3	3.0	3.4	3.6	3.7	3.4	3.2	3.5	3.5	3.6	2.8	3.3	2.4	3.7	2.0	2.7	2.8	1.9	3.5	2.7	3.6
Basal metabolic rate	4.9	27.3	39.2	5.8	-6.2	-6.2	5.1	5.4	4.8	4.7	5.5	6.0	4.8	6.3	6.1	4.7	5.3	3.1	5.6	5.3	5.3	2.8	5.6	2.7	5.7	5.0	4.6	5.6
Whole body water mass	4.8	27.7	42.1	5.7	-6.3	-6.4	5.3	5.4	4.7	4.8	5.6	6.0	4.7	6.5	6.3	4.5	5.3	2.8	5.8	5.6	5.3	2.4	5.8	2.6	5.8	4.9	4.8	5.5
Average weekly champagne plus white wine intake	4.8	6.6	13.5	-1.8	3.0	2.9	0.1	-3.3	-3.2	-3.4	-2.3	-2.6	-2.3	-2.4	-3.1	-2.2	-2.8	-0.9	-1.4	-3.7	-3.3	-1.2	-0.7	-1.8	-2.9	-2.8	-2.7	-3.2
Qualifications: CSEs or equivalent	4.6	6.1	14.0	1.1	-1.7	-2.0	0.4	2.7	1.7	3.1	2.9	2.9	2.8	1.9	2.5	2.8	3.0	1.1	1.2	3.2	3.3	2.9	0.7	3.7	1.2	3.0	2.2	3.2
Serious illness, injury or assault to yourself	4.4	5.3	11.3	2.0	-2.2	-1.9	-0.3	3.4	3.0	3.1	2.4	2.4	2.1	1.9	2.5	2.2	2.4	1.4	0.9	3.3	2.9	2.0	0.4	2.3	1.3	2.5	2.6	2.7
Illnesses of father: High blood pressure	4.3	5.4	11.8	2.6	-2.5	-1.9	0.5	3.1	2.2	2.8	1.9	2.3	2.2	2.2	2.5	2.3	2.5	1.4	1.4	3.4	2.6	2.1	1.1	2.3	2.1	2.4	2.7	2.6
Weight	4.2	20.8	29.6	5.1	-5.4	-5.4	4.1	4.8	4.4	4.1	4.8	5.3	4.5	5.1	5.0	4.4	4.8	3.3	4.8	3.8	4.7	2.7	4.7	2.2	5.2	4.5	4.0	5.0
Standing height	4.2	42.1	70.1	5.2	-8.2	-8.3	5.8	6.4	6.6	6.2	6.9	7.2	5.3	8.4	8.2	5.1	6.5	2.8	6.3	6.2	6.8	2.0	6.7	2.2	8.3	6.0	7.6	7.0
Height	3.8	73.9	130.0	7.4	-11.0	-11.0	8.3	8.3	7.5	8.1	9.4	9.6	6.9	11.4	10.9	6.4	8.4	4.4	8.7	8.5	8.7	1.9	9.4	1.9	11.2	7.7	10.0	8.9
Sensitivity / hurt feelings	3.8	6.5	14.9	2.3	-3.4	-3.1	1.9	2.8	1.2	2.6	3.1	2.8	1.7	3.2	3.4	1.8	2.3	1.2	2.4	3.9	2.7	0.5	2.2	1.1	2.0	2.1	3.8	2.6
Heart disease (siblings)	3.8	4.7	10.6	-1.4	2.5	2.9	-1.8	-2.6	-1.6	-2.4	-2.7	-2.4	-1.1	-2.7	-2.9	-1.2	-1.8	-0.5	-2.1	-2.3	-2.4	-0.8	-2.1	-1.8	-2.2	-1.6	-3.3	-2.3
Waist circumference	3.7	13.5	18.6	4.3	-3.7	-3.7	2.7	4.2	3.9	3.5	3.7	4.3	4.1	3.6	3.7	4.2	4.1	3.5	3.6	2.8	4.0	3.1	3.2	2.6	3.5	4.1	2.5	4.3
Qualifications: College or University degree	3.6	11.5	20.6	-4.5	2.6	3.0	-2.4	-3.6	-3.1	-3.2	-3.6	-4.1	-4.1	-3.1	-3.4	-4.3	-4.1	-3.8	-3.3	-2.3	-3.6	-2.8	-3.0	-2.6	-3.2	-4.0	-1.6	-3.8
Leg fat-free mass (right)	3.6	19.3	30.6	4.8	-5.5	-5.3	4.1	4.6	4.1	4.0	4.6	4.9	3.9	5.3	5.2	3.8	4.4	2.1	4.6	4.8	4.4	2.2	4.7	2.2	4.8	4.1	4.3	4.6
Leg predicted mass (right)	3.6	19.3	30.5	4.8	-5.5	-5.3	4.1	4.6	4.1	4.0	4.6	4.9	3.9	5.3	5.2	3.9	4.4	2.1	4.6	4.9	4.5	2.2	4.6	2.1	4.8	4.1	4.4	4.7
Verbal and Numeric Reasoning (VNR)	3.5	8.5	14.5	-2.8	2.5	2.6	-1.3	-3.1	-3.3	-3.1	-2.7	-3.2	-3.5	-2.7	-2.9	-3.6	-3.5	-2.0	-2.1	-3.8	-3.2	-3.3	-1.8	-3.1	-2.0	-3.4	-2.1	-3.3
Medication: Metformin	3.5	5.0	10.8	1.0	-0.9	-1.7	2.6	2.3	1.7	2.3	2.7	2.8	2.5	2.3	2.4	2.5	2.5	2.7	3.3	1.3	2.5	1.2	2.8	0.9	1.4	2.5	2.0	2.4
Exposure to tobacco smoke outside home	3.5	4.6	7.1	2.6	-2.4	-2.5	2.1	1.7	1.3	1.6	2.6	2.7	2.2	2.2	2.4	2.4	2.3	0.6	2.0	1.8	2.3	1.5	2.1	2.3	2.5	2.2	1.2	2.5
Leg fat-free mass (left)	3.4	18.2	28.8	4.8	-5.4	-5.2	4.2	4.4	3.9	3.8	4.5	4.8	3.8	5.2	5.0	3.7	4.2	1.9	4.6	4.4	4.2	2.4	4.7	2.1	4.8	4.0	4.0	4.5
Leg predicted mass (left)	3.4	18.2	28.2	4.7	-5.3	-5.1	4.1	4.5	3.9	3.8	4.5	4.8	3.8	5.1	5.0	3.8	4.3	1.9	4.5	4.5	4.3	2.4	4.6	2.1	4.7	4.0	4.1	4.5
Knee pain experienced in last month	3.4	5.3	11.7	2.2	-2.6	-2.3	0.6	2.8	2.4	2.9	1.9	2.6	2.7	1.8	2.3	2.7	2.8	0.7	1.8	2.8	2.9	0.5	1.4	1.0	3.4	2.8	1.1	3.0
Ever had hysterectomy (womb removed)	3.3	3.7	8.0	1.9	-1.0	-2.0	2.6	2.0	1.6	1.4	2.5	2.4	2.1	2.1	1.9	2.2	2.0	1.9	2.7	0.5	1.7	0.2	2.8	0.5	2.5	1.9	1.4	1.8
Other serious medical condition/disability diagnosed by doctor	3.1	4.0	10.2	2.0	-1.9	-1.9	0.9	2.5	1.9	2.4	2.4	2.1	1.5	1.9	2.3	1.6	1.9	1.2	1.5	1.8	2.4	1.8	1.1	2.8	0.9	1.9	3.2	2.3
Sitting height	3.1	22.1	32.1	4.5	-5.3	-5.5	3.8	4.8	5.0	4.8	4.9	5.3	4.4	5.7	5.7	4.2	5.0	1.7	4.5	4.3	5.2	2.5	4.5	3.1	5.5	4.8	5.0	5.3
Back pain experienced in last month	3.1	4.5	10.7	2.1	-2.4	-2.5	2.6	2.2	0.8	1.6	2.5	2.4	1.6	2.7	2.6	1.6	1.9	1.1	3.0	2.1	1.8	-0.2	2.8	0.3	3.3	1.6	1.9	1.9
Irritability	3.1	5.2	9.6	1.2	-2.0	-2.7	2.0	2.7	1.6	2.4	3.1	2.8	1.5	2.8	2.9	1.6	2.0	1.2	2.7	2.9	2.4	1.2	2.4	1.3	2.4	1.8	2.9	2.3
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.3	9.3	0.5	-2.8	-2.5	1.3	2.2	3.0	2.9	2.3	2.8	2.7	2.6	2.9	2.6	2.9	1.3	2.2	3.0	3.0	1.3	1.8	2.5	2.6	2.9	2.5	3.0
Ever used hormone-replacement therapy (HRT)	2.8	3.6	10.6	3.3	-1.5	-1.9	2.9	1.5	1.0	0.7	2.6	2.2	1.6	2.3	1.8	1.5	1.5	2.9	2.9	1.2	1.1	0.9	3.0	0.3	1.4	1.3	0.6	1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	5.4	0.6	-1.5	-1.8	2.0	1.6	1.5	1.8	2.0	2.2	1.8	2.0	2.1	1.8	1.9	2.3	2.3	1.2	1.9	0.5	2.2	0.3	2.2	1.8	2.1	2.0
Leg fat mass (left)	2.8	10.8	17.6	4.2	-3.8	-3.8	3.1	3.3	3.1	2.6	3.4	3.9	3.5	3.4	3.4	3.5	3.5	3.0	3.6	2.0	3.2	2.4	3.5	1.5	3.7	3.3	2.5	3.5
Waist Hip Ratio (WHR)	2.7	12.1	19.7	3.4	-2.2	-2.7	1.6	3.6	3.7	3.9	3.4	4.1	4.2	3.3	3.7	4.4	4.3	3.5	2.8	3.2	4.2	4.0	2.2	3.3	2.4	4.3	1.9	4.3
Basal cell carcinoma (self-reported)	2.7	3.2	7.4	-2.1	1.8	2.1	-1.9	-2.1	-0.4	-1.6	-2.7	-2.1	-1.0	-2.4	-2.5	-0.9	-1.5	-1.5	-1.9	-1.5	-1.9	-0.5	-1.7	-1.5	-1.2	-1.3	-2.2	-1.8
Townsend deprivation index at recruitment	2.6	3.7	8.7	1.3	-2.0	-2.4	1.7	2.3	1.4	1.9	2.5	2.0	1.1	2.5	2.7	1.0	1.6	0.8	2.3	3.0	1.9	0.1	1.8	0.2	2.1	1.4	2.8	1.8
Maternal smoking around birth	2.6	3.8	8.6	-1.2	2.7	2.9	-1.6	-2.0	-1.6	-2.1	-2.1	-2.1	-1.1	-2.6	-2.8	-1.1	-1.7	-0.1	-1.6	-2.0	-2.2	0.2	-1.8	0.5	-2.3	-1.6	-2.8	-2.0
Miserableness	2.6	4.5	7.6	2.5	-2.2	-2.4	1.6	2.3	1.6	2.5	2.8	2.6	2.0	2.2	2.4	2.1	2.2	1.2	2.0	2.1	2.4	1.6	2.0	1.4	2.3	2.1	1.5	2.2
Breastfed as a baby	2.5	3.2	6.1	-1.8	0.9	1.1	-0.5	-1.8	-2.5	-2.1	-1.5	-2.0	-2.2	-1.1	-1.6	-2.3	-2.2	-2.0	-1.3	-1.8	-2.2	-1.5	-0.9	-2.4	-1.1	-2.3	-0.9	-2.3
Leg fat mass (right)	2.5	9.6	17.1	4.1	-3.6	-3.6	3.1	3.0	2.9	2.4	3.2	3.6	3.3	3.2	3.1	3.3	3.3	2.8	3.5	1.7	3.0	2.3	3.4	1.2	3.6	3.1	2.3	3.3
Commuting to job workplace: Cycle	2.5	3.0	5.9	-2.1	1.5	1.4	-0.3	-2.1	-2.2	-2.1	-1.3	-1.9	-2.3	-1.0	-1.5	-2.4	-2.2	-1.9	-1.2	-1.2	-2.2	-1.2	-0.9	-0.1	-1.8	-2.4	-1.1	-2.2
Taking other prescription medications	2.4	3.7	8.5	1.8	-0.3	-1.1	0.6	2.9	2.0	2.1	1.9	2.1	2.3	1.2	1.5	2.5	2.2	2.6	1.6	1.2	2.2	2.6	0.9	2.7	0.6	2.3	0.9	2.3
Rheumatoid Arthritis	2.3	3.2	6.8	1.7	-1.9	-2.1	1.0	1.8	1.5	2.1	1.8	2.0	2.1	1.8	1.9	2.1	2.1	1.0	1.8	0.7	1.9	1.0	1.7	-0.2	2.6	2.1	1.6	2.0
Pulse wave reflection index	2.3	2.8	5.0	-2.0	1.9	1.8	-1.6	-1.1	-2.2	-1.5	-1.5	-1.9	-1.8	-1.7	-1.8	-1.6	-1.9	-1.0	-1.7	-0.9	-1.9	-0.6	-1.6	-1.7	-1.8	-1.9	-1.5	-2.0
Neuroticism	2.2	5.2	10.3	2.6	-3.1	-2.8	1.6	2.8	1.4	2.3	2.7	2.6	1.4	2.7	2.8	1.6	1.9	1.8	2.5	3.2	2.3	0.5	2.1	0.8	2.0	1.8	3.0	2.2
Impedance of arm (right)	2.2	10.3	19.3	-4.4	3.3	3.5	-3.5	-3.6	-2.6	-2.8	-3.6	-3.7	-2.9	-3.7	-3.6	-2.9	-3.2	-2.0	-4.1	-4.2	-3.0	-1.3	-3.7	-2.1	-2.6	-3.0	-1.3	-3.2
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	12.0	3.5	-1.3	-1.4	1.1	2.1	1.3	1.7	1.3	1.7	1.8	1.3	1.3	1.8	1.7	1.9	1.6	1.5	1.4	1.7	1.6	2.0	1.2	1.7	0.7	1.5
Medication: Lansoprazole	2.2	2.5	4.9	1.5	-0.8	-1.2	-0.1	1.9	1.2	2.0	1.6	1.8	2.2	1.3	1.5	2.2	2.1	1.2	0.9	0.8	2.0	2.0	0.5	1.9	1.0	2.2	0.4	2.0
Handedness (chirality/laterality): Left-handed	2.2	2.7	7.4	0.7	-2.7	-2.3	2.0	0.9	0.5	1.2	1.5	1.7	1.4	2.3	2.1	1.5	1.6	0.4	2.0	1.5	1.5	0.3	2.0	-0.7	2.4	1.5	1.6	1.5
Alzheimer’s Disease (in mother)	2.1	2.5	6.2	-2.5	1.5	1.5	-1.6	-2.0	-1.1	-1.6	-1.8	-1.9	-1.7	-1.5	-1.5	-1.8	-1.8	-0.8	-1.4	-1.4	-1.7	-1.1	-1.5	-0.2	-1.5	-1.7	-1.1	-1.8
Alcohol usually taken with meals	2.1	3.4	7.6	-1.5	2.8	2.2	-0.0	-2.3	-2.4	-2.2	-1.2	-1.7	-1.7	-1.6	-2.0	-1.6	-1.9	-1.4	-0.7	-2.1	-2.1	-0.9	-0.5	-1.7	-2.8	-1.9	-1.8	-2.0
Impedance of arm (left)	2.1	9.9	21.0	-4.6	2.6	3.2	-4.0	-3.2	-2.0	-2.5	-3.6	-3.7	-3.1	-3.5	-3.3	-3.0	-3.2	-2.9	-4.3	-3.9	-2.8	-1.6	-4.0	-1.8	-2.1	-2.9	-0.9	-3.0
Medication: Ventolin 100micrograms inhaler	2.1	2.7	7.0	-2.6	1.8	1.7	-0.7	-1.4	-2.2	-1.7	-1.3	-1.6	-1.6	-2.0	-1.9	-1.7	-1.8	-0.1	-1.3	-2.6	-1.6	-1.2	-1.1	-1.5	-1.1	-1.7	-1.1	-1.6
Osteoarthritis (self-reported)	2.1	2.7	7.6	2.0	0.1	-0.9	1.1	2.3	1.0	1.5	1.8	1.9	2.1	1.0	1.2	1.9	1.8	2.8	1.9	1.1	1.7	1.9	1.5	1.9	0.3	1.9	0.4	1.8
Stomach or abdominal pain in last month	2.0	2.5	7.6	-0.3	1.3	1.8	-2.8	-0.8	-0.1	-1.1	-1.8	-1.8	-1.1	-2.2	-2.0	-1.0	-1.4	0.6	-2.3	-1.4	-1.5	1.1	-2.5	0.0	-1.5	-1.3	-1.9	-1.5
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.9	1.2	-0.9	-1.1	-0.3	1.7	1.1	1.9	1.5	1.8	2.0	0.8	1.1	2.1	1.9	1.0	1.1	1.8	1.8	2.2	0.5	2.4	0.8	2.0	1.1	1.9
Whole body fat mass	2.0	8.2	12.7	3.6	-3.2	-3.1	2.4	2.9	3.0	2.3	2.8	3.4	3.2	2.8	2.8	3.3	3.2	2.8	2.9	1.4	2.9	2.5	2.8	1.5	3.3	3.1	2.2	3.2
Pain experienced in last month	2.0	3.3	9.0	-2.5	1.8	1.6	-0.7	-3.0	-1.4	-2.3	-1.9	-1.9	-1.5	-1.7	-2.0	-1.7	-1.8	-1.0	-2.0	-2.8	-2.1	-0.8	-1.3	-1.3	-1.4	-1.7	-1.9	-1.9
Age at First Birth	1.9	2.8	6.4	-1.2	1.0	1.4	-1.0	-1.6	-1.4	-1.7	-1.5	-2.0	-2.5	-1.4	-1.5	-2.5	-2.3	-1.9	-1.1	-1.1	-1.9	-0.5	-1.2	-1.5	-1.6	-2.3	-1.2	-2.2
Crohns Disease (2012)	1.9	3.0	6.7	2.3	-2.2	-2.4	2.6	1.5	0.0	1.3	1.7	1.8	1.4	2.5	2.1	1.3	1.6	1.8	2.5	0.0	1.3	0.0	2.6	0.0	2.2	1.3	0.0	1.3
Trunk fat mass	1.9	8.0	11.9	3.5	-3.3	-3.1	2.1	2.9	3.1	2.4	2.7	3.3	3.1	2.8	2.8	3.2	3.1	2.6	2.8	1.2	2.9	2.4	2.6	1.4	3.4	3.0	2.6	3.2
Forced vital capacity (FVC)	1.9	7.5	12.3	2.3	-3.4	-3.3	2.5	1.7	2.3	2.4	2.8	3.1	2.7	3.3	3.3	2.7	3.0	0.7	2.5	2.9	2.9	1.0	2.8	1.3	3.5	2.8	3.5	3.1
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	9.6	1.7	-2.4	-2.7	2.2	1.5	1.9	2.2	2.9	3.1	2.9	2.8	2.9	2.9	3.0	1.1	2.6	2.9	2.8	1.6	2.6	1.5	2.9	2.9	3.0	3.0
Chronic bronchitis/emphysema (mother)	1.9	2.3	5.2	-0.5	0.8	1.2	-0.0	-1.8	-1.2	-2.0	-1.3	-1.8	-2.1	-1.1	-1.4	-2.0	-2.1	-1.3	-0.9	-1.4	-2.0	-1.3	-0.6	-2.3	-0.5	-2.1	-0.3	-2.0
High blood pressure (siblings)	1.9	2.7	6.3	2.5	-2.4	-2.0	1.7	1.3	0.8	1.2	1.3	1.7	1.5	1.9	1.7	1.7	1.6	2.0	1.7	1.8	1.4	0.7	1.8	-0.5	2.2	1.5	0.7	1.6
Medication: Seretide 50 evohaler	1.9	2.2	7.9	-0.8	2.1	2.3	-1.6	-1.0	-0.9	-0.8	-1.9	-1.5	-0.2	-2.1	-2.0	-0.2	-0.7	-0.0	-1.5	-1.4	-1.1	0.2	-1.7	0.8	-2.8	-0.5	-2.4	-1.2
Neuroticism (Nagel 2018)	1.8	4.2	9.4	1.8	-2.4	-2.3	1.3	2.5	1.3	2.2	2.3	2.4	1.5	2.6	2.7	1.6	1.9	1.1	2.1	3.1	2.2	0.9	1.8	0.8	1.8	1.8	3.0	2.0
Heel T-Score	1.8	14.5	37.6	-3.8	3.9	4.8	-5.9	-2.8	-2.7	-2.3	-4.4	-4.4	-3.1	-4.5	-3.9	-3.4	-3.3	-3.2	-6.1	-1.9	-2.8	-0.7	-5.9	0.9	-4.8	-2.9	-3.6	-3.0
Systolic Blood Pressure	1.8	9.1	15.9	-1.4	1.1	2.7	-3.5	-2.1	-2.0	-2.4	-3.0	-3.8	-4.0	-3.3	-3.1	-3.8	-3.8	-3.0	-3.9	-1.7	-2.9	-3.8	-3.8	-3.0	-1.7	-3.6	-1.8	-3.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	6.4	-2.0	0.5	0.7	-0.6	-1.8	-1.1	-1.7	-1.9	-1.8	-1.6	-1.3	-1.4	-1.8	-1.6	-0.7	-1.0	-1.9	-1.7	-0.4	-0.9	-2.5	-0.9	-1.6	-0.7	-1.6
Medication: Ramipril	1.8	2.3	4.3	-1.6	1.0	1.1	0.3	-1.7	-1.8	-1.9	-1.4	-1.7	-2.1	-0.8	-1.1	-2.1	-2.0	-1.1	-0.7	-1.6	-1.8	-1.7	-0.3	-1.0	-1.9	-2.0	-0.6	-1.8
Fluid intelligence score	1.8	3.8	7.9	-1.8	1.6	1.6	-0.6	-2.3	-2.6	-2.3	-1.7	-2.0	-2.3	-1.6	-1.9	-2.4	-2.3	-1.1	-1.4	-2.8	-2.2	-1.8	-1.0	-2.2	-1.1	-2.3	-2.0	-2.2
Depression (self-reported)	1.8	2.1	4.9	-0.4	2.1	1.8	-1.6	-1.3	-1.1	-1.4	-1.8	-1.6	-0.8	-2.2	-2.0	-0.8	-1.2	-0.8	-1.9	-1.8	-1.2	-0.7	-1.9	-0.2	-1.5	-1.0	-1.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.1	-0.7	1.7	1.9	-1.9	-1.4	-1.2	-1.3	-2.0	-1.8	-1.2	-1.8	-1.9	-1.2	-1.5	-1.6	-1.8	-0.9	-1.6	0.4	-1.8	0.0	-1.2	-1.4	-2.2	-1.6
Had other major operations	1.7	2.0	6.6	0.7	-0.7	-0.8	0.7	1.6	0.8	1.4	1.5	1.6	1.9	1.1	1.3	2.0	1.8	1.1	0.9	1.5	1.7	2.1	0.6	2.6	0.0	1.8	0.4	1.7
Mouth/teeth dental problems	1.7	2.7	11.3	-1.1	2.2	2.0	-0.6	-2.2	-0.9	-2.0	-1.6	-1.5	-0.7	-2.0	-2.2	-0.6	-1.3	0.7	-1.6	-3.4	-1.8	0.5	-1.1	-0.4	-2.1	-1.2	-1.9	-1.5
Pulse rate	1.7	2.9	8.2	0.3	-1.5	-2.0	2.3	2.1	1.1	1.4	2.3	2.1	1.2	1.5	1.7	1.1	1.4	2.5	2.9	0.5	1.7	-0.6	2.4	-0.1	1.8	1.3	1.4	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	9.2	1.8	-2.4	-2.6	1.5	1.7	2.1	2.4	2.4	2.7	2.7	2.4	2.6	2.7	2.8	0.8	2.1	3.0	2.7	1.3	2.0	2.1	2.4	2.8	2.5	2.8
Leg pain on walking	1.7	2.1	3.4	1.3	-1.2	-1.4	0.9	1.7	1.0	1.6	1.6	1.7	1.6	1.2	1.3	1.9	1.6	1.5	1.5	1.3	1.6	1.2	1.1	1.8	1.5	1.6	0.8	1.6
Supplements: Vitamin C	1.7	2.0	5.0	-0.8	0.7	1.4	-0.6	-1.4	-1.4	-1.7	-2.0	-1.7	-1.3	-1.7	-1.8	-1.2	-1.6	0.7	-0.8	-1.9	-1.8	-2.2	-0.6	-1.2	0.3	-1.5	-1.6	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	10.4	1.3	-1.1	-1.5	1.2	1.8	1.3	0.9	1.5	1.5	1.4	1.2	1.1	1.5	1.3	3.2	1.7	0.3	1.1	1.4	1.4	0.6	0.8	1.3	0.6	1.2
Number of self-reported non-cancer illnesses	1.7	2.9	6.9	1.2	-1.0	-1.4	1.1	2.6	1.8	2.0	1.9	2.0	1.6	1.5	1.8	1.6	1.8	1.4	1.9	2.0	2.1	1.5	1.2	1.6	0.2	1.8	2.0	2.1
Alcohol drinker status: Previous	1.7	2.0	4.7	-1.5	1.8	1.8	-1.7	-0.8	-1.2	-1.0	-1.6	-1.4	-1.1	-2.2	-1.9	-1.1	-1.4	-0.6	-1.1	-1.4	-1.2	0.1	-1.7	0.6	-2.0	-1.2	-1.5	-1.2
Triglycerides	1.6	2.6	5.6	-1.5	1.9	1.7	-0.2	-2.0	-2.4	-2.0	-1.5	-1.8	-1.7	-1.4	-1.8	-1.7	-1.9	0.0	-0.9	-1.5	-2.1	-0.6	-0.6	-1.5	-0.9	-1.9	-1.7	-2.1
Medication for hormone replacement therapy	1.6	1.8	7.3	2.7	-2.0	-1.5	0.9	1.5	1.2	0.8	1.3	1.4	1.0	1.3	1.1	1.0	1.0	1.4	1.1	0.7	0.9	1.4	1.2	0.9	1.9	0.9	1.1	1.0
High blood pressure (mother)	1.6	2.2	4.5	2.1	-1.0	-1.4	1.2	1.1	1.0	1.5	1.4	1.8	1.9	1.4	1.3	1.9	1.8	0.5	1.8	0.8	1.4	1.7	1.5	1.6	1.8	1.7	-0.0	1.5
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.1	1.4	-1.3	-1.0	0.5	1.8	0.5	1.6	1.5	1.7	1.8	1.0	1.3	1.9	1.7	2.3	1.1	1.3	1.8	0.7	0.8	1.3	0.8	1.8	0.6	1.8
Medication: Ibuprofen	1.6	1.9	5.1	2.3	-1.1	-1.1	0.6	1.7	1.1	1.5	0.9	1.4	1.6	1.0	1.1	1.5	1.5	1.5	1.0	1.4	1.3	1.8	1.0	2.2	0.6	1.5	0.3	1.4
Overall health rating	1.6	3.3	8.9	2.0	-2.2	-1.9	0.5	3.0	1.9	2.0	2.2	1.8	1.1	1.7	2.1	1.4	1.5	1.3	1.0	2.5	2.0	1.5	0.6	2.2	1.3	1.5	2.5	2.0
Chest pain or discomfort	1.6	2.3	8.8	2.0	-0.8	-0.6	-1.1	3.0	1.2	2.4	1.1	1.3	1.6	0.3	1.1	1.6	1.7	1.2	-0.2	1.3	2.1	0.7	-0.6	2.7	0.7	1.9	0.9	1.9
Wears glasses or contact lenses	1.6	1.9	4.1	-1.4	1.0	0.9	-2.0	-0.7	-0.6	-1.0	-1.3	-1.7	-1.7	-1.5	-1.4	-1.7	-1.6	-1.7	-1.8	-1.2	-1.2	-1.1	-1.9	-0.4	-0.9	-1.5	-0.4	-1.4
Number of operations (self-reported)	1.6	2.4	6.8	1.4	-0.7	-0.8	0.9	1.5	0.8	1.3	1.6	1.9	2.1	1.3	1.4	2.1	2.0	1.0	1.4	1.8	1.8	1.7	0.9	2.6	0.3	2.0	0.6	1.9
Neuroticism (2016)	1.5	2.2	5.5	0.9	-1.9	-2.0	2.4	1.7	0.4	1.1	2.0	1.6	0.5	2.1	1.9	0.6	0.9	1.4	2.0	2.0	1.0	-0.2	2.2	0.8	1.3	0.6	1.3	0.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	5.0	1.6	-0.5	-0.3	0.3	0.5	1.1	1.1	0.7	1.3	2.2	0.6	0.7	2.2	1.9	1.1	0.3	0.2	1.5	1.6	0.4	2.0	1.3	1.9	-1.2	1.6
Diabetes (self-reported)	1.5	2.3	5.1	0.2	-1.2	-1.4	1.4	1.8	1.6	1.9	2.2	1.9	1.4	1.7	1.9	1.5	1.6	0.9	1.8	1.2	1.9	0.9	1.4	1.3	1.0	1.6	1.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	7.2	2.3	-1.1	-1.2	1.3	1.4	1.0	1.3	1.2	1.5	1.5	1.0	1.0	1.6	1.4	2.7	1.6	0.6	1.1	0.9	1.5	0.6	1.5	1.3	0.7	1.1
Diabetes diagnosed by doctor	1.5	2.4	4.6	0.4	-1.0	-1.0	1.0	2.1	1.6	2.2	2.0	1.9	1.7	1.4	1.7	1.8	1.9	1.4	1.5	1.3	2.1	1.0	1.1	1.6	0.5	1.9	1.0	2.0
Leg fat percentage (left)	1.5	5.4	9.7	2.8	-2.4	-2.5	2.0	2.3	2.3	1.7	2.4	2.8	2.7	2.1	2.1	2.8	2.6	3.1	2.8	0.8	2.2	1.7	2.4	1.0	2.5	2.5	1.5	2.5
Ever depressed for a whole week	1.5	1.9	8.8	2.1	-2.1	-1.6	1.2	1.6	-0.5	1.0	1.4	1.3	0.8	1.1	1.1	0.7	0.9	3.0	1.9	0.5	1.0	-0.3	1.6	-0.2	1.6	0.9	1.3	1.0
Chronotype (morning person)	1.4	3.2	9.7	-0.2	2.5	2.1	-0.6	-1.4	-0.9	-2.1	-1.3	-1.8	-1.4	-1.9	-2.4	-1.4	-1.9	2.3	-1.1	-3.1	-2.2	0.5	-0.9	-0.4	-2.6	-1.8	-2.0	-2.1
Had menopause	1.4	1.8	5.6	2.1	-2.4	-1.8	1.2	1.5	0.6	0.8	1.4	0.9	-0.1	1.9	1.7	-0.2	0.4	-0.6	1.2	1.7	0.8	-1.8	1.3	-1.2	1.6	0.2	1.6	0.6
Pain all over the body in last month	1.4	1.5	3.5	-0.0	-1.4	-1.5	0.6	1.5	0.4	1.5	1.4	1.3	0.8	1.5	1.6	0.9	1.2	0.8	1.1	1.9	1.5	1.0	0.8	1.2	1.1	1.1	1.7	1.4
Neuroticism score	1.4	3.0	8.8	2.0	-2.3	-2.1	1.0	2.1	0.4	1.8	2.1	2.0	0.9	2.0	2.1	1.1	1.4	1.0	1.8	3.0	1.7	0.5	1.4	0.9	1.6	1.2	2.2	1.6
Qualifications: A levels/AS levels or equivalent	1.4	3.2	6.2	-2.1	1.7	1.4	-0.0	-2.5	-1.6	-2.0	-1.5	-1.8	-2.2	-1.2	-1.6	-2.3	-2.1	-2.4	-1.0	-2.2	-2.0	-1.7	-0.5	-1.8	-1.6	-2.2	-0.6	-2.0
Prospective memory result	1.4	1.7	4.3	2.1	-1.2	-1.3	1.6	1.0	1.9	1.0	1.3	1.3	1.1	1.6	1.5	1.2	1.2	-0.4	0.9	1.4	1.1	0.2	1.2	1.7	1.2	1.1	1.6	1.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	7.9	0.9	-2.0	-1.7	0.3	1.5	1.1	1.7	1.0	1.1	0.8	1.4	1.6	0.5	1.1	-1.6	0.6	2.8	1.4	0.0	0.7	0.4	1.9	1.1	0.9	1.4
Eye problems/disorders: Glaucoma	1.4	1.7	9.2	-2.0	0.9	1.1	-3.0	0.2	-0.7	0.0	-1.0	-1.1	-0.8	-1.5	-1.0	-0.8	-0.8	-1.1	-1.8	0.4	-0.3	0.5	-2.7	1.2	-2.2	-0.5	-0.2	-0.4
Depressed Affect (Nagel 2018)	1.3	2.7	4.4	1.8	-1.3	-1.7	1.7	1.5	1.4	1.5	1.6	2.1	1.9	1.8	1.8	2.0	1.9	1.5	1.9	1.6	1.7	1.4	1.9	0.4	1.3	1.8	1.3	1.7
Medication: Atenolol	1.3	1.6	3.3	0.8	0.3	1.3	-1.8	-0.9	-0.7	-1.1	-0.9	-1.4	-1.6	-1.3	-1.3	-1.4	-1.5	-1.2	-1.6	-1.2	-1.3	-1.0	-1.8	-0.4	-1.4	-1.5	-1.0	-1.4
Age at first live birth	1.3	2.2	5.8	-2.0	1.5	1.8	-1.0	-1.7	-0.9	-1.5	-1.5	-1.7	-1.7	-1.3	-1.5	-1.7	-1.7	-1.8	-1.4	-0.3	-1.7	0.0	-1.3	-0.0	-2.4	-1.7	-0.3	-1.7
Eye problems/disorders: None of the above	1.3	1.5	8.8	0.2	-0.3	-0.5	2.0	-1.1	-0.8	-1.2	0.2	-0.3	-1.2	0.6	0.1	-1.2	-1.1	-0.3	0.9	-0.9	-1.1	-1.9	1.6	-3.0	1.2	-1.3	1.0	-1.2
Supplements: Calcium	1.3	1.4	5.5	0.6	-0.7	-1.1	2.3	0.5	0.3	0.4	1.3	0.9	0.1	1.5	1.2	0.1	0.3	1.6	2.2	0.4	0.3	-1.2	2.2	-1.0	1.2	0.1	2.0	0.2
Alzheimer’s Disease (including proxy)	1.2	1.8	5.8	-2.4	1.3	1.1	-1.4	-1.2	-1.2	-1.0	-1.3	-1.5	-1.8	-1.2	-1.0	-1.8	-1.6	-1.4	-1.2	-0.5	-1.2	-1.6	-1.3	-0.2	-1.0	-1.6	0.3	-1.3
Age when periods started (menarche)	1.2	2.9	6.8	-2.4	2.2	1.7	-0.6	-2.0	-2.6	-1.7	-1.5	-1.8	-2.1	-1.4	-1.5	-2.0	-2.0	-1.6	-0.9	-0.9	-1.8	-0.9	-0.9	-1.5	-1.6	-2.0	-1.0	-2.0
Multivitamins +/- minerals	1.2	1.5	4.3	0.7	-1.1	-1.1	1.8	0.9	0.0	0.7	0.8	1.3	1.3	1.6	1.2	1.3	1.2	2.1	1.8	0.7	0.7	0.5	1.8	-1.2	1.8	1.1	1.0	1.0
Heart attack	1.2	1.6	3.9	-1.4	1.3	0.9	-0.2	-1.3	-1.3	-1.8	-1.0	-1.1	-1.0	-1.3	-1.5	-1.0	-1.2	1.0	-0.8	-2.0	-1.4	-1.2	-0.5	-1.3	-1.1	-1.2	-2.0	-1.3
Noisy workplace	1.2	1.5	5.8	1.0	-0.3	-0.3	-0.9	1.8	1.6	1.5	1.0	1.1	1.7	0.3	0.6	1.8	1.5	2.4	0.3	1.1	1.4	1.0	-0.3	1.3	0.1	1.6	0.7	1.4
Medication: Cholesterol lowering	1.2	1.9	3.2	-0.5	1.6	1.8	-0.6	-1.8	-1.3	-1.7	-1.6	-1.6	-1.3	-1.5	-1.7	-1.2	-1.6	-0.6	-1.1	-1.3	-1.8	-0.9	-1.0	-1.0	-1.8	-1.6	-0.7	-1.8
Osteoporosis (self-reported)	1.2	1.5	5.0	0.5	0.7	0.8	0.2	-0.8	-1.4	-1.4	-0.3	-1.3	-2.2	-0.6	-0.8	-2.1	-1.9	-0.4	-0.2	-1.0	-1.5	-1.6	-0.2	-1.1	-1.5	-2.0	-0.2	-1.6
Medication: Gliclazide	1.2	1.3	5.4	0.3	-0.1	-0.3	0.5	0.5	1.3	1.2	0.2	1.3	2.3	0.4	0.5	2.3	1.9	1.1	0.8	0.2	1.3	1.2	0.6	0.2	0.7	2.0	-1.1	1.5
Hearing aid user	1.2	1.3	6.4	-1.4	1.1	0.4	0.4	-1.2	-1.0	-1.5	-0.7	-0.8	-0.9	-0.9	-1.2	-1.0	-1.1	1.5	0.1	-2.5	-1.4	-1.2	0.2	-1.5	-0.6	-1.2	-0.9	-1.3
Smoking Status	1.1	2.5	4.8	1.7	-1.6	-1.9	1.2	1.9	0.8	1.5	1.6	1.9	1.8	1.2	1.4	1.9	1.8	2.2	1.7	0.5	1.6	1.4	1.6	0.2	2.2	1.7	1.1	1.7
Arm fat mass (right)	1.1	4.4	10.8	3.3	-2.2	-2.0	1.6	2.2	1.9	1.6	1.9	2.4	2.4	1.7	1.8	2.5	2.3	2.3	2.1	1.0	2.1	2.2	1.9	1.6	1.9	2.3	1.4	2.4
Exposure to tobacco smoke at home	1.1	1.3	3.6	1.7	-1.7	-1.0	-0.3	1.9	1.3	1.6	1.2	0.9	0.5	0.8	1.2	0.5	0.8	0.2	0.1	1.8	1.4	0.8	-0.0	1.6	0.9	0.9	0.6	1.2
Leg fat percentage (right)	1.1	3.9	7.5	2.7	-2.0	-2.1	1.8	1.8	1.9	1.3	2.0	2.4	2.4	1.7	1.7	2.4	2.2	2.7	2.3	0.1	1.8	1.7	2.0	0.7	2.3	2.1	1.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.4	-1.9	1.2	1.3	-1.3	-0.8	-0.9	-0.9	-0.8	-1.0	-0.5	-1.5	-1.2	-0.4	-0.7	-0.3	-1.5	-1.7	-0.6	-1.1	-1.6	-0.7	-1.2	-0.5	-0.8	-0.5
Eye problems/disorders: Cataract	1.1	1.2	5.6	-0.3	-0.2	0.0	-2.1	1.1	0.7	1.4	-0.2	0.5	1.1	-0.3	0.3	1.1	1.1	-0.8	-0.9	1.0	1.4	1.4	-1.6	2.4	-0.3	1.3	-0.6	1.4
Alcohol drinker status: Never	1.1	1.3	8.8	1.0	0.4	-0.2	2.4	-0.3	-1.1	-0.8	1.0	0.4	-0.1	0.9	0.3	-0.1	-0.2	3.0	1.9	-1.5	-0.5	-1.0	2.0	-1.4	0.2	-0.4	-0.7	-0.5
Fractured/broken bones in last 5 years	1.1	1.5	4.2	1.5	-0.5	-0.6	1.0	1.4	2.1	1.2	1.1	1.4	1.3	1.2	1.3	1.3	1.4	1.1	1.0	0.9	1.2	0.9	1.1	1.8	-0.2	1.3	0.8	1.4
Schizophrenia (2018)	1.0	2.1	3.7	-0.7	1.7	1.8	-1.2	-1.8	-0.7	-1.7	-1.6	-1.6	-1.0	-1.6	-1.9	-0.8	-1.4	-0.1	-1.4	-1.8	-1.9	0.7	-1.2	-0.5	-1.6	-1.4	-1.7	-1.8
Vitamin and mineral supplements	1.0	1.3	5.5	-0.7	1.2	1.1	-1.9	-0.7	0.3	-0.3	-0.8	-0.9	-0.4	-1.2	-0.9	-0.4	-0.5	-2.4	-1.8	-0.4	-0.4	1.5	-1.8	1.3	-1.9	-0.4	-1.0	-0.5
Severe depression (siblings)	1.0	1.1	2.7	-0.4	0.4	0.6	-0.8	-1.0	-1.2	-1.1	-1.0	-1.3	-1.6	-0.7	-0.9	-1.6	-1.4	0.8	-1.1	0.4	-1.4	-0.7	-1.0	-1.1	-0.9	-1.5	-0.3	-1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	3.2	1.3	-1.8	-1.4	1.5	0.6	1.0	0.4	1.1	1.0	0.7	1.1	1.2	0.8	0.8	0.8	1.3	0.8	0.9	0.2	1.3	-0.3	1.2	0.8	1.8	1.1
Financial difficulties in last 2 years	1.0	1.3	3.4	1.7	-1.2	-1.0	0.4	1.7	0.4	1.0	1.5	1.1	0.9	0.9	1.0	1.0	1.0	1.6	1.0	1.9	1.1	1.2	0.6	1.3	0.6	1.0	0.7	1.0
Hip circumference	1.0	4.2	7.6	2.5	-2.8	-2.4	2.3	2.1	2.0	1.4	1.9	2.4	2.1	2.1	2.0	2.0	2.1	1.6	2.3	1.2	2.0	1.1	2.3	0.6	2.3	2.0	1.9	2.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.8	1.1	-1.5	-1.6	0.9	0.5	1.6	1.2	1.7	1.5	1.1	1.3	1.4	1.1	1.2	-0.0	1.3	1.2	1.3	0.6	1.2	0.8	1.4	1.2	1.6	1.3
Forced vital capacity (FVC), Best measure	1.0	3.7	6.7	1.8	-2.6	-2.4	1.2	1.4	1.9	1.9	1.7	2.1	1.9	2.1	2.3	1.8	2.2	-0.1	1.4	2.3	2.2	0.2	1.6	1.4	2.5	2.1	2.4	2.3
Comparative body size at age 10	1.0	2.9	4.8	2.2	-1.7	-1.4	1.2	1.9	1.8	1.7	1.5	2.0	2.0	1.3	1.5	1.9	1.9	2.1	1.9	1.6	1.8	1.2	1.6	1.3	0.9	1.9	1.0	2.0
Arm fat mass (left)	1.0	4.3	9.1	3.0	-2.4	-2.2	1.6	2.2	2.1	1.6	1.9	2.4	2.4	1.8	1.8	2.5	2.3	2.1	2.0	1.1	2.1	2.1	1.8	1.5	2.1	2.2	1.6	2.4
Diastolic blood pressure, automated reading	1.0	3.1	11.1	1.7	-2.2	-1.9	1.0	2.4	1.9	2.1	1.8	1.7	0.8	1.9	2.2	0.9	1.3	0.3	1.3	3.3	2.0	-1.4	1.1	1.0	1.7	1.3	2.5	1.9
Bipolar Disorder or Schizophrenia	0.9	2.2	5.0	-0.7	1.6	1.7	-0.9	-2.2	-0.8	-1.9	-1.9	-1.7	-0.9	-1.6	-1.9	-0.6	-1.3	-0.7	-1.4	-1.7	-2.0	1.0	-1.1	-0.1	-1.8	-1.4	-2.1	-1.8
Prostate Cancer	0.9	1.3	6.0	-0.7	1.3	0.7	0.7	-1.4	-1.0	-1.8	-1.0	-0.9	-0.5	-0.6	-1.3	-0.4	-1.0	0.7	0.1	-1.7	-1.7	0.0	0.4	-1.2	-0.9	-1.1	-2.4	-1.4
Fasting Glucose	0.9	1.0	1.9	-1.0	-0.3	0.4	-0.9	-1.4	-1.1	-1.2	-1.0	-1.1	-1.2	-1.3	-1.3	-1.1	-1.3	-0.6	-0.8	-0.7	-1.2	-0.8	-0.9	-1.2	-0.3	-1.2	-0.9	-1.2
HDL Cholesterol	0.9	1.5	6.7	0.5	-1.0	-1.7	2.6	0.4	-0.7	0.1	1.6	1.3	0.4	1.9	1.4	0.4	0.6	0.7	2.0	1.4	0.4	-0.7	2.3	-0.8	0.8	0.3	0.9	0.7
Lung FEV1/FVC ratio	0.9	4.4	10.5	1.2	-0.7	-2.1	2.7	1.5	0.7	1.4	3.2	2.7	1.9	2.4	2.1	2.0	1.9	2.3	3.2	2.6	1.7	2.1	2.8	1.9	1.5	1.7	1.6	1.8
Average weekly fortified wine intake	0.9	1.1	3.8	-0.4	2.0	1.5	-0.9	-1.5	0.2	-1.2	-0.7	-0.9	-0.5	-1.2	-1.4	-0.6	-0.8	-0.2	-1.0	-1.5	-1.2	0.3	-1.0	0.4	-0.7	-0.8	-1.2	-1.1
Loud music exposure frequency	0.9	1.0	5.1	0.8	-0.2	-0.2	-0.9	0.5	0.7	1.1	0.1	0.6	1.1	0.1	0.5	1.1	1.1	-0.2	-0.5	1.8	1.0	2.1	-0.7	2.3	0.5	1.1	0.2	1.1
Worry too long after embarrassment	0.9	1.5	4.1	1.7	-2.0	-1.4	0.3	1.6	-0.1	1.5	1.4	1.2	0.6	1.3	1.4	0.7	0.9	0.2	0.7	2.0	1.2	0.8	0.6	1.7	0.8	0.9	0.9	1.1
Smoking status: Current	0.9	1.5	3.8	1.0	-1.0	-1.2	0.1	1.8	0.8	1.5	1.1	1.3	1.2	0.9	1.2	1.3	1.3	2.0	0.8	0.8	1.4	1.5	0.5	1.2	1.3	1.3	0.9	1.4
Ever taken oral contraceptive pill	0.9	1.1	5.1	0.1	-0.5	-1.0	2.0	-0.0	-0.2	0.3	0.7	1.0	1.1	1.0	0.8	1.0	0.9	2.3	1.8	-0.3	0.5	1.1	1.7	0.8	0.6	0.8	0.2	0.7
Ovarian Cancer	0.8	1.0	3.7	-0.3	0.6	-0.2	1.5	-1.2	-0.8	-1.4	-0.2	-0.6	-1.3	0.0	-0.5	-1.3	-1.3	0.9	0.5	-1.3	-1.4	-0.2	1.1	-1.9	0.0	-1.4	0.2	-1.3
Hearing difficulty/problems: Yes	0.8	1.3	3.2	-0.6	-1.2	-1.2	0.2	1.3	0.9	1.2	1.4	1.3	1.4	0.8	0.9	1.2	1.4	1.8	0.3	0.2	1.5	1.1	0.3	0.8	0.3	1.4	1.5	1.5
Hand grip strength (right)	0.8	2.2	5.4	-0.8	0.6	1.3	-0.6	-2.3	-1.0	-1.9	-2.1	-1.8	-1.5	-1.4	-1.5	-1.7	-1.6	-1.6	-1.1	-0.9	-1.8	-1.6	-1.0	-1.8	-1.3	-1.6	-1.2	-1.7
Current tobacco smoking	0.8	1.3	3.8	1.1	-0.9	-1.0	0.1	1.7	0.8	1.3	1.0	1.2	1.1	0.7	1.0	1.2	1.2	2.0	0.6	0.9	1.3	1.4	0.4	1.3	0.9	1.2	0.7	1.3
Relative age voice broke	0.8	1.3	2.5	-1.5	0.3	0.7	-0.7	-0.9	-1.6	-0.9	-1.2	-1.5	-1.5	-1.0	-1.1	-1.4	-1.4	-1.1	-0.9	-0.8	-1.3	-0.8	-0.9	-0.9	-0.3	-1.4	-1.4	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	5.2	0.4	1.3	1.8	-2.1	-0.5	-1.0	-0.6	-1.3	-1.6	-1.1	-1.6	-1.4	-1.1	-1.2	-0.5	-2.3	-0.8	-1.0	0.7	-2.1	1.5	-1.7	-1.0	-1.6	-1.2
Qualifications: None of the above	0.8	1.7	5.4	1.3	-0.5	-0.7	0.0	2.3	1.3	1.7	1.4	1.4	1.6	0.8	1.2	1.6	1.6	1.7	0.5	1.0	1.7	0.8	0.2	1.8	0.9	1.6	0.6	1.6
Father’s age at death	0.8	1.0	3.4	-1.2	0.4	0.8	-0.8	-0.3	-1.5	-0.6	-0.6	-1.0	-1.3	-0.9	-0.8	-1.4	-1.2	-1.0	-0.6	-0.9	-0.8	-1.3	-0.7	-1.8	-0.9	-1.1	0.1	-1.1
Happiness	0.8	0.9	3.0	0.1	0.5	0.8	0.4	-1.7	-1.3	-1.7	-1.1	-0.9	-0.6	-0.5	-1.0	-0.7	-0.9	-0.4	-0.4	-1.1	-1.4	-0.6	0.1	-0.8	-0.5	-1.0	-1.6	-1.2
Birth weight	0.8	1.8	5.0	1.0	-0.9	-1.3	-0.7	1.7	1.5	2.2	1.1	1.1	0.7	1.1	1.7	0.7	1.2	-0.6	0.3	2.2	1.8	0.8	-0.2	2.1	-0.0	1.2	2.1	1.5
Pulse wave peak to peak time	0.8	0.9	3.5	1.9	-1.6	-1.3	0.9	0.3	1.3	0.7	0.8	0.6	0.2	1.2	1.2	-0.1	0.5	0.0	0.7	0.5	0.7	-0.6	0.9	0.3	1.6	0.4	1.4	0.6
Medication: Blood pressure	0.8	1.3	3.0	-1.1	0.5	0.9	-0.8	-0.9	-0.7	-1.1	-1.0	-1.4	-1.7	-0.8	-0.9	-1.5	-1.5	-1.5	-1.0	-0.7	-1.2	-1.5	-1.0	-1.7	-0.6	-1.5	-0.6	-1.4
Medication: Omeprazole	0.8	1.0	5.3	0.6	0.6	0.1	0.8	1.1	0.6	0.5	1.1	1.1	1.3	0.3	0.3	1.4	1.0	2.3	1.0	-0.4	0.7	1.5	0.7	1.4	-0.5	1.0	-0.1	0.9
Medication: Aspirin	0.8	1.0	3.7	0.1	0.6	0.8	0.1	-0.7	-1.0	-1.1	-0.6	-1.1	-1.4	-0.8	-1.0	-1.3	-1.4	-1.1	-0.2	-0.5	-1.3	-1.9	-0.3	-0.5	-1.1	-1.4	-1.0	-1.4
Qualifications: nursing, teaching	0.8	1.2	3.3	-1.0	0.4	0.8	0.1	-1.8	-1.1	-1.5	-1.5	-1.3	-1.3	-0.7	-1.0	-1.4	-1.3	-0.7	-0.1	-1.0	-1.5	-0.2	-0.1	-1.5	-0.9	-1.4	-0.6	-1.4
Mother’s age at death	0.8	1.0	7.3	-0.9	1.0	0.8	-0.3	-1.1	-0.4	-0.7	-1.1	-1.1	-1.0	-0.4	-0.4	-1.0	-0.9	-2.7	-0.6	-1.1	-0.8	-1.4	-0.4	-1.1	-0.7	-0.9	-0.8	-0.8
Risk taking	0.8	1.2	5.4	0.7	-1.2	-0.8	-0.1	1.5	1.8	1.2	1.2	1.1	0.8	0.5	0.8	0.8	0.9	2.3	0.8	0.8	1.1	1.8	0.2	0.7	0.5	1.0	1.0	1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.6	-1.1	0.8	0.3	0.5	-1.0	-1.2	-1.6	-0.5	-0.7	-0.8	-0.7	-1.0	-0.8	-1.0	1.3	-0.1	-1.6	-1.2	-1.5	0.2	-1.5	-0.6	-1.0	-1.5	-1.0
Blood Eosinophil Count	0.7	5.7	9.3	2.3	-2.2	-2.7	1.9	2.9	3.0	2.6	2.4	2.6	2.2	2.8	2.8	2.2	2.5	1.1	2.7	2.6	2.6	0.7	2.3	1.4	2.6	2.4	2.1	2.5
Blood Red Count	0.7	6.9	16.0	2.9	-2.8	-2.8	1.5	4.0	3.6	3.0	2.5	2.8	2.8	2.7	2.8	2.9	3.0	1.8	2.5	2.8	2.8	0.7	2.1	1.6	2.2	2.9	1.2	2.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.9	0.8	0.8	1.2	-1.7	-0.7	-0.4	-0.5	-1.7	-1.0	-0.1	-1.2	-1.1	-0.2	-0.4	-0.3	-1.6	0.3	-0.7	1.4	-1.5	0.7	-0.5	-0.3	-2.0	-0.6
Systolic blood pressure, automated reading	0.7	2.1	7.5	0.5	-0.1	1.2	-2.1	-0.2	-0.5	-0.7	-1.1	-1.7	-2.0	-1.5	-1.1	-1.9	-1.7	-1.6	-2.3	0.3	-1.0	-2.7	-2.2	-1.6	-0.6	-1.5	-0.7	-1.2
Body mass index (BMI)	0.7	3.1	7.9	2.8	-1.7	-1.7	1.7	1.9	1.4	1.2	1.8	2.1	2.1	1.3	1.3	2.2	1.9	2.1	2.1	0.9	1.6	1.8	1.8	1.2	1.5	1.9	0.6	1.9
Number of incorrect matches in round	0.7	1.2	5.2	1.3	-1.2	-0.9	0.3	1.9	0.5	1.0	1.3	1.2	0.9	1.2	1.1	1.0	1.0	2.3	0.6	1.4	0.9	0.8	0.7	0.8	0.8	0.9	1.0	0.9
Worrier / anxious feelings	0.7	1.4	5.2	1.3	-1.3	-1.4	1.1	1.0	-0.2	0.9	1.6	1.3	0.5	1.4	1.2	0.7	0.7	-0.2	1.7	2.3	0.8	-0.0	1.5	0.4	1.3	0.6	1.9	0.7
Peak expiratory flow (PEF)	0.7	1.6	4.4	-0.5	-0.2	-0.3	0.5	0.4	0.7	1.0	1.2	1.6	2.1	0.6	0.8	2.1	1.8	0.8	1.2	1.5	1.5	1.9	0.8	1.0	0.0	1.9	1.4	1.7
Blood clot in the leg (DVT)	0.7	0.9	1.6	1.3	-0.7	-0.7	0.6	0.9	0.8	1.0	1.0	1.0	1.1	0.9	1.0	1.1	1.1	0.5	1.1	1.0	1.1	0.9	0.7	1.0	1.0	1.1	0.1	1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.5	0.3	-0.7	-0.9	0.3	1.2	0.8	1.3	0.9	1.3	1.5	0.7	1.0	1.4	1.4	1.3	0.7	0.8	1.4	1.0	0.7	1.6	0.8	1.5	0.3	1.5
Gout (self-reported)	0.7	0.9	2.7	-0.2	0.2	-0.5	0.8	0.8	0.9	1.0	1.6	1.4	1.1	0.9	1.0	1.0	1.1	1.3	1.0	0.2	1.3	0.8	0.8	0.8	0.4	1.1	0.9	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.6	-0.1	-1.1	-0.8	0.3	1.0	1.0	0.9	0.9	1.1	1.1	0.9	0.9	1.2	1.1	0.2	0.6	1.6	1.0	0.2	0.6	-0.5	0.1	1.1	1.0	1.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.8	1.9	-1.2	-0.7	0.1	0.7	0.1	0.4	0.4	0.8	1.1	0.8	0.8	1.1	1.0	0.4	0.3	1.9	0.7	-0.0	0.4	0.6	1.0	1.0	-0.6	0.9
Ever had bowel cancer screening	0.7	0.8	2.6	0.3	-1.3	-1.4	-0.0	1.3	0.7	0.8	0.9	0.9	0.5	1.0	1.1	0.5	0.7	0.4	0.7	1.6	0.8	-0.4	0.5	-0.5	1.1	0.6	1.6	0.8
Medication for cholesterol	0.7	1.0	5.1	-2.3	1.5	1.4	-1.3	-0.5	-0.4	0.0	-0.9	-0.8	-0.5	-1.0	-0.5	-0.5	-0.4	-1.7	-1.3	-0.1	-0.1	-1.3	-1.5	-1.0	-1.3	-0.2	-0.3	-0.2
Breast cancer (self-reported)	0.7	0.8	3.7	1.0	-0.8	-0.3	-0.2	1.0	0.8	1.1	0.6	0.7	1.1	0.4	0.6	1.1	1.0	0.4	-0.1	0.6	1.0	1.9	-0.1	1.9	0.2	1.1	-0.2	0.9
Medication: Blood pressure	0.7	1.3	3.8	2.0	-1.8	-1.5	1.3	1.0	0.4	0.4	1.6	1.1	0.3	1.5	1.1	0.4	0.5	1.5	1.3	0.9	0.6	1.0	1.4	0.9	1.2	0.3	0.8	0.6
Impedance of whole body	0.7	3.7	10.1	-3.2	1.8	2.0	-2.8	-2.0	-0.8	-1.2	-2.2	-2.1	-1.6	-2.2	-2.0	-1.5	-1.6	-1.3	-2.8	-3.1	-1.4	-0.9	-2.7	-1.1	-0.8	-1.4	-0.3	-1.6
Alzheimer’s Disease (in father)	0.6	0.6	2.1	-1.5	0.7	0.7	-1.2	-0.1	-1.0	-0.1	-0.8	-0.8	-0.9	-0.9	-0.5	-0.9	-0.7	-0.9	-0.9	-0.3	-0.2	-0.9	-1.1	-1.1	-0.3	-0.6	1.0	-0.3
Reaction Time	0.6	1.2	4.7	1.7	-0.3	0.2	-0.6	0.9	1.2	0.8	0.2	0.6	1.5	0.2	0.1	1.6	1.2	2.2	-0.6	-0.1	0.8	2.0	-0.5	2.0	-0.6	1.3	-0.3	0.9
Breast Cancer	0.6	1.3	5.0	1.7	-2.0	-1.6	1.0	1.0	0.6	0.8	1.0	1.0	0.8	1.2	1.2	0.7	1.0	2.2	1.1	0.6	0.9	0.8	1.1	0.8	1.3	0.9	1.0	0.9
Allergy or Eczema	0.6	1.5	3.9	0.5	1.5	1.4	-0.7	-1.3	-1.4	-1.4	-1.3	-1.2	-1.1	-1.9	-1.8	-1.1	-1.4	0.1	-0.6	-2.0	-1.4	-0.3	-0.8	-0.2	-1.7	-1.2	-0.7	-1.4
Hand grip strength (left)	0.6	1.7	5.2	0.4	0.1	0.6	0.7	-1.8	-0.9	-1.8	-1.3	-1.3	-1.6	-0.7	-1.0	-1.7	-1.5	-0.5	-0.3	-1.0	-1.7	-2.2	0.2	-2.3	-0.5	-1.6	-1.0	-1.6
Number of treatments/medications taken	0.6	1.0	5.7	2.4	0.2	0.1	0.2	1.2	0.5	0.5	0.3	0.7	1.2	-0.1	-0.1	1.4	0.8	2.2	0.8	-0.2	0.5	1.5	0.3	1.8	-0.1	0.9	-0.7	0.6
Relative age of first facial hair	0.6	1.3	3.1	-1.4	0.5	0.8	-1.8	-0.8	-0.9	-0.6	-1.4	-1.5	-1.0	-1.2	-1.2	-1.1	-1.0	-0.8	-1.5	-1.5	-1.0	0.4	-1.6	-0.8	-0.1	-1.0	-1.3	-1.2
Trunk fat percentage	0.6	2.3	4.2	1.9	-1.7	-1.4	0.6	1.5	2.0	1.1	1.1	1.7	1.9	0.9	1.0	2.0	1.7	1.9	1.2	-0.4	1.5	1.7	1.0	0.7	1.9	1.7	1.5	1.8
Time employed in main current job	0.6	0.7	3.3	1.4	-1.8	-1.5	0.9	0.5	0.3	0.2	0.7	0.4	0.1	0.5	0.5	0.1	0.2	0.9	1.0	-0.5	0.3	-1.3	0.9	-1.0	1.3	0.2	0.3	0.2
Alcohol intake versus 10 years previously	0.6	0.9	5.4	0.6	-0.6	-1.0	2.3	0.4	-0.7	-0.1	1.0	0.6	-0.3	1.1	0.9	-0.2	-0.0	1.4	1.8	0.1	0.0	-0.7	1.9	-1.4	1.1	-0.2	0.5	0.1
Hair/balding pattern: Pattern 3	0.6	0.9	3.9	-0.2	2.0	1.3	0.7	-1.1	-1.1	-1.1	-0.6	-0.7	-0.8	-0.7	-0.9	-0.7	-1.0	-0.8	0.1	-1.0	-1.1	-0.1	0.2	-0.1	-1.3	-1.0	-1.5	-1.1
Number of live births	0.6	0.9	3.0	-1.7	1.1	0.4	0.2	-0.8	-1.7	-1.2	-0.7	-0.8	-0.6	-0.6	-0.8	-0.5	-0.7	0.4	-0.1	-1.5	-1.0	-0.7	-0.1	-1.6	-0.8	-0.8	-1.2	-1.0
Mouth/teeth dental problems: Dentures	0.6	1.1	2.4	0.7	-1.5	-1.4	0.7	1.3	0.6	0.8	1.1	1.1	0.8	1.3	1.3	0.9	1.0	1.0	1.3	1.1	1.1	0.0	0.9	-0.2	1.2	0.9	1.2	1.1
Asthma	0.6	1.1	4.8	-2.2	1.1	0.9	-0.8	-0.2	-1.2	-0.6	-0.6	-0.8	-0.9	-1.4	-1.1	-1.0	-0.9	-1.4	-0.8	-1.7	-0.5	-1.5	-1.0	-1.1	-0.2	-0.8	-0.4	-0.5
Glaucoma (self-reported)	0.6	0.6	4.6	-0.9	0.1	0.2	-2.1	0.9	0.2	0.7	0.0	-0.2	-0.2	-0.5	-0.1	0.0	0.0	-0.3	-0.9	0.7	0.5	0.8	-1.7	1.2	-1.3	0.1	0.8	0.4
Body fat percentage	0.6	2.4	4.8	2.1	-1.6	-1.5	0.8	1.4	1.8	1.0	1.3	1.8	2.0	1.0	1.0	2.1	1.7	2.2	1.4	-0.3	1.4	1.8	1.2	0.7	1.8	1.8	1.1	1.8
Number of full brothers	0.6	0.7	10.6	0.1	0.6	0.3	1.1	0.3	0.0	-0.4	0.2	0.2	0.2	0.0	-0.2	0.6	0.0	3.3	0.8	-1.3	-0.2	-1.3	0.8	-0.4	-0.2	0.0	-0.1	-0.1
Health satisfaction	0.6	0.8	2.3	1.3	-1.1	-0.9	0.7	0.7	0.5	0.6	1.2	1.0	1.0	1.1	1.0	1.0	1.0	1.5	0.4	0.5	0.9	0.4	0.6	0.4	0.8	0.9	0.3	1.0
Shortness of breath walking on level ground	0.6	0.7	2.9	0.1	-0.8	-0.6	-0.7	1.0	1.0	1.0	0.8	0.8	0.9	0.2	0.6	1.0	0.9	-0.2	-0.3	0.4	1.1	0.7	-0.5	1.7	0.5	1.0	0.1	1.1
Mean time to correctly identify matches	0.6	1.1	2.9	1.2	-0.5	-0.2	-0.2	1.2	1.2	1.1	0.5	0.9	1.7	0.6	0.5	1.7	1.4	1.5	-0.1	0.5	1.0	1.6	-0.1	1.6	-0.3	1.5	-0.0	1.1
Had major operations	0.6	0.6	3.0	0.5	0.7	1.1	-1.0	-0.2	-0.1	-0.4	-0.8	-0.6	-0.1	-1.2	-0.9	-0.1	-0.3	-0.1	-1.1	-0.6	-0.3	0.4	-1.2	1.4	-1.2	-0.2	-1.7	-0.2
Average weekly red wine intake	0.6	0.9	4.5	-0.6	-0.7	-0.6	0.9	-0.6	-2.1	-1.1	-0.2	-0.7	-1.7	0.4	0.0	-1.9	-1.4	-0.1	0.2	0.2	-1.0	-0.7	0.4	-1.1	-0.4	-1.5	0.2	-1.0
Asthma (self-reported)	0.6	1.2	4.0	-2.0	1.3	1.0	-0.6	-0.3	-1.6	-0.8	-0.5	-0.8	-1.0	-1.4	-1.2	-1.0	-1.0	-1.1	-0.8	-1.9	-0.6	-1.6	-0.9	-1.4	-0.1	-0.8	-0.4	-0.6
Medication: Aspirin	0.6	0.8	3.8	0.1	0.6	0.8	0.2	-0.5	-0.9	-1.0	-0.5	-0.9	-1.2	-0.6	-0.8	-1.1	-1.2	-0.7	-0.0	-0.4	-1.1	-2.0	-0.2	-0.4	-1.1	-1.2	-0.8	-1.2
Illnesses of father: None of the above (group 1)	0.6	0.8	8.4	-1.2	1.6	0.7	0.0	-1.0	0.2	-0.7	-0.5	-0.2	0.2	-0.7	-0.8	0.1	-0.1	-0.2	-0.3	-2.9	-0.5	-0.6	0.1	-0.5	-0.0	-0.1	-1.7	-0.3
Financial situation satisfaction	0.6	0.7	2.5	1.3	1.0	1.1	-1.6	-0.1	0.0	-0.1	-0.8	-0.5	0.7	-1.2	-1.0	0.6	0.2	0.7	-1.1	-0.0	-0.1	0.7	-1.2	1.4	-0.7	0.4	-1.1	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.6	0.2	1.1	0.8	-0.6	-0.7	-1.2	-1.1	-0.9	-0.9	-0.8	-0.9	-0.9	-0.8	-0.9	0.6	-0.6	-0.8	-0.9	0.7	-0.8	-0.0	-1.6	-0.8	-0.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.1	0.8	0.5	1.2	-1.2	-0.1	-1.5	-0.6	-1.0	-0.8	-0.6	-1.4	-1.2	-0.6	-0.8	-0.5	-0.8	-0.6	-0.7	-0.2	-1.1	-0.5	-1.2	-0.7	-1.4	-0.6
Medication: Paracetamol	0.6	1.0	7.4	0.9	0.5	0.7	-1.1	0.7	0.0	0.6	-0.1	0.2	1.1	-0.7	-0.4	1.1	0.7	1.6	-0.9	-0.2	0.5	1.6	-1.0	2.7	-0.7	0.9	-0.8	0.5
Medication: Atorvastatin	0.6	0.7	2.5	-0.0	1.1	1.5	-0.5	-0.6	-1.4	-0.8	-0.8	-0.8	-0.5	-1.1	-1.1	-0.3	-0.7	0.0	-0.8	-1.1	-0.8	0.5	-0.7	-0.1	-1.6	-0.7	-0.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.7	1.3	-0.6	-0.4	0.1	0.9	0.8	1.1	0.8	0.9	1.1	0.6	0.8	1.1	1.1	0.4	0.6	1.0	1.0	0.9	0.3	1.2	0.6	1.1	-0.2	1.0
Depression (Nagel 2018)	0.5	0.8	2.9	1.1	0.5	1.1	-1.7	-0.6	0.0	-0.5	-1.4	-0.8	0.1	-1.2	-1.1	0.0	-0.3	-0.9	-1.5	0.2	-0.6	0.7	-1.4	0.3	-1.0	-0.2	-1.1	-0.8
Crohns Disease (2017)	0.5	1.2	3.3	1.8	-0.7	-1.3	1.5	1.1	1.3	0.8	1.0	0.8	0.3	1.5	1.4	0.3	0.6	1.3	1.4	0.3	0.7	-1.0	1.4	0.5	0.8	0.4	1.6	0.6
Mean Putamen Volume	0.5	0.5	4.7	-0.2	0.5	-0.0	1.4	-0.8	0.1	-0.8	0.2	0.0	-0.1	0.5	0.1	0.1	-0.1	-0.1	1.1	-0.2	-0.6	-1.1	1.2	-2.2	-0.0	-0.3	-0.3	-0.5
Primary Biliary Cirrhosis	0.5	0.7	1.5	-0.5	0.8	1.0	-0.8	-0.9	-0.1	-0.9	-1.2	-1.0	-0.5	-1.2	-1.2	-0.7	-0.8	-0.1	-1.0	-1.1	-0.9	-0.2	-1.0	0.1	-0.8	-0.7	-0.6	-0.9
BMI	0.5	2.7	5.9	2.2	-1.4	-1.7	2.4	1.5	1.4	0.8	1.4	1.9	2.0	1.4	1.2	2.1	1.7	2.2	2.1	0.4	1.3	1.6	2.2	1.3	1.2	1.6	0.4	1.7
Diabetes (father)	0.5	0.7	2.6	0.4	-0.5	-0.8	1.4	0.5	-0.5	0.3	1.3	0.9	0.2	0.8	0.8	0.3	0.4	1.4	1.6	0.8	0.6	-0.7	1.2	-0.5	0.2	0.3	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.8	1.0	0.9	1.3	-2.2	0.1	-0.2	0.3	-1.0	-0.9	-0.5	-1.2	-0.8	-0.6	-0.5	-0.4	-2.0	-0.3	-0.2	1.5	-1.9	1.9	-1.3	-0.3	-1.0	-0.4
Illnesses of siblings	0.5	0.7	3.1	-1.5	1.8	0.9	-0.3	-0.3	-0.5	-0.3	-0.1	-0.6	-0.9	-0.7	-0.5	-1.0	-0.8	-1.7	-0.4	-0.4	-0.4	-0.3	-0.4	0.7	-1.2	-0.7	0.7	-0.6
Falls in the last year	0.5	0.7	4.5	0.6	-1.3	-0.5	-1.5	1.7	0.4	1.0	-0.0	0.1	0.1	-0.2	0.4	0.4	0.3	0.4	-1.1	0.7	0.9	0.3	-1.2	2.1	0.1	0.5	0.3	0.8
Tense / ‘highly strung’	0.5	0.8	2.2	-0.6	-0.1	0.4	-1.3	0.0	-1.2	-0.5	-0.9	-1.1	-1.4	-0.5	-0.5	-1.4	-1.2	-1.0	-0.7	0.4	-0.9	-0.8	-0.9	-1.5	-0.0	-1.2	-0.1	-1.0
Wheeze or whistling in the chest in last year	0.5	0.9	1.9	0.0	0.5	1.1	-0.7	-0.6	-0.9	-1.0	-1.1	-1.1	-0.9	-1.4	-1.2	-0.8	-1.0	-0.4	-1.2	-1.4	-0.9	-0.4	-1.1	-0.6	-1.1	-0.9	-0.8	-0.9
Emphysema/chronic bronchitis	0.5	0.5	1.9	0.1	-0.8	-1.0	1.2	0.6	-0.0	0.2	0.9	0.6	0.1	1.0	0.9	0.1	0.3	1.4	1.0	0.1	0.4	-0.4	1.0	-1.2	0.5	0.2	0.6	0.5
Medication: Allopurinol	0.5	0.6	1.3	-0.1	0.1	-0.5	0.7	0.5	1.0	0.9	1.1	1.1	1.0	0.7	0.8	0.9	1.0	0.5	0.6	0.6	1.1	0.7	0.5	0.7	0.6	1.1	0.8	1.1
Pulse rate, automated reading	0.5	1.6	5.2	-0.3	-1.1	-1.3	1.9	1.3	0.1	0.8	1.3	1.4	0.9	1.1	1.2	1.0	1.0	2.0	2.3	1.5	1.0	0.9	1.8	0.1	1.1	0.9	1.1	1.2
Number of full sisters	0.5	0.6	4.7	-2.2	0.3	-0.2	0.7	-0.5	-0.5	-0.7	0.1	-0.4	-1.0	0.0	-0.0	-0.9	-0.8	-1.3	0.2	-0.3	-0.5	-0.8	0.3	-1.0	0.5	-0.9	-0.0	-0.6
Suffer from ‘nerves’	0.5	0.7	2.4	0.7	-0.1	0.4	-0.6	-0.5	-1.5	-0.7	-0.2	-0.9	-1.6	-0.6	-0.6	-1.3	-1.3	-0.3	-0.7	-0.3	-0.9	-1.2	-0.6	-1.0	0.4	-1.3	0.0	-1.0
Commuting to job workplace: Walk	0.5	0.5	3.8	-2.0	1.3	0.6	0.3	-0.8	-0.8	-0.6	0.1	-0.3	-0.5	-0.5	-0.6	-0.6	-0.6	-0.1	0.2	-1.2	-0.5	-0.5	0.1	-0.9	-0.5	-0.5	0.1	-0.5
Commuting to job workplace: Public transport	0.5	0.6	2.1	-0.9	-0.3	-0.9	1.2	-0.1	0.3	0.7	0.6	0.7	0.5	0.9	1.0	0.5	0.7	-0.6	1.1	0.4	0.8	-0.4	1.0	-1.3	0.6	0.7	1.4	0.9
High cholesterol (Self-reported)	0.5	0.8	1.9	0.4	0.3	0.5	-0.1	-0.3	-1.1	-1.0	-1.0	-1.2	-1.0	-0.8	-1.1	-1.0	-1.2	0.1	-0.5	-1.3	-1.3	-0.8	-0.3	-1.4	-0.4	-1.2	-0.9	-1.4
Age started oral contraceptive pill	0.5	0.6	1.9	1.4	-0.5	-0.9	1.2	0.7	1.0	0.6	0.9	0.6	0.3	0.9	0.8	0.2	0.5	0.6	0.6	0.3	0.6	-0.9	1.1	-1.1	0.7	0.5	1.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	4.2	0.8	0.7	0.5	-0.1	0.8	0.4	0.3	0.4	0.5	0.9	-0.4	-0.3	1.1	0.6	2.0	0.3	-0.9	0.4	1.0	-0.0	1.2	-0.9	0.7	-0.2	0.5
Body Mass Index (BMI) (2010)	0.4	0.5	3.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.2	-1.5	0.2	-0.6	-0.9	-0.2	-1.3	-1.9	-1.3
HbA1C	0.4	0.4	2.2	-0.0	-0.4	-0.3	-0.6	0.4	1.5	0.6	0.2	0.3	0.4	-0.1	0.1	0.5	0.5	0.1	-0.4	1.3	0.4	1.1	-0.5	1.4	-0.2	0.5	0.3	0.4
Schizophrenia (2014)	0.4	1.0	5.0	0.1	1.0	1.0	-1.1	-1.0	0.0	-0.9	-1.2	-0.8	-0.2	-1.1	-1.3	0.1	-0.5	-0.6	-1.2	-1.2	-1.0	1.3	-0.9	0.7	-0.9	-0.5	-2.2	-0.9
Diabetes (mother)	0.4	0.5	1.5	1.2	0.8	0.6	0.2	0.4	-0.5	0.5	0.0	0.5	0.9	-0.1	-0.0	0.9	0.7	1.2	0.9	-0.5	0.6	0.9	0.3	1.2	-0.6	0.8	-0.8	0.7
Medication: Levothyroxine sodium	0.4	0.7	2.5	-0.7	-0.9	-1.0	1.6	-0.1	-0.1	-0.2	0.8	0.5	-0.2	1.2	0.9	-0.1	0.1	0.6	1.3	-0.2	0.1	-0.9	1.3	-1.1	1.2	-0.1	1.3	0.2
Nervous feelings	0.4	0.8	2.3	0.7	-1.1	-0.5	-0.1	-0.2	-1.0	-0.2	0.1	-0.5	-1.5	0.5	0.4	-1.4	-1.0	-1.4	-0.3	1.2	-0.5	-1.5	-0.1	-1.4	0.2	-1.1	1.2	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-0.1	-0.4	-1.0	0.5	1.2	0.1	1.1	1.1	1.0	0.9	0.9	0.9	0.7	0.9	1.2	0.8	0.7	0.9	1.0	0.7	0.4	0.6	0.9	0.4	0.9
Headache pain in last month	0.4	0.7	8.0	1.3	0.8	0.8	-0.6	0.8	-0.2	0.6	-0.2	0.1	0.7	-0.5	-0.3	0.8	0.5	1.0	-0.3	0.7	0.3	0.6	-0.5	2.8	-0.9	0.6	-0.7	0.3
Hypertension (Self-reported)	0.4	1.0	3.9	0.9	-1.7	-1.5	1.0	1.4	0.0	0.5	1.5	0.9	-0.2	1.6	1.4	0.1	0.2	0.5	1.1	2.0	0.7	-0.0	0.9	-0.1	1.2	0.1	1.0	0.6
Mood swings	0.4	0.7	2.2	0.2	-0.6	-0.8	1.3	0.7	-0.0	0.4	0.9	1.1	0.8	0.9	0.8	1.1	0.8	1.5	1.3	1.0	0.6	0.2	1.3	0.2	0.9	0.7	0.4	0.6
Unable to work because of sickness or disability	0.4	0.5	2.4	0.6	-0.3	0.0	-1.5	1.2	0.1	0.6	0.2	0.1	0.1	-0.3	0.2	0.2	0.2	0.8	-0.9	1.3	0.7	0.8	-1.2	1.3	-0.1	0.3	1.0	0.5
Myopia	0.4	0.6	3.0	-0.4	-0.7	-1.1	1.2	0.2	0.1	-0.2	0.8	0.1	-0.8	0.7	0.5	-0.7	-0.5	0.4	0.8	-0.6	-0.3	-0.9	1.0	-1.7	0.5	-0.7	1.3	-0.3
Bipolar Disorder (2018)	0.3	0.5	1.6	-0.3	0.4	0.5	0.1	-1.1	0.0	-1.0	-1.0	-0.7	-0.2	-0.5	-0.7	0.0	-0.4	-0.9	-0.5	-0.5	-0.8	0.7	-0.3	0.6	-0.9	-0.4	-1.3	-0.7
Worry (Nagel 2018)	0.3	0.6	4.5	-0.3	-0.7	-0.6	-0.0	0.6	-0.5	0.2	0.5	0.1	-0.9	0.7	0.7	-0.8	-0.4	-0.8	0.6	1.5	0.0	-1.1	0.3	-1.3	0.5	-0.5	2.1	-0.3
Cardiovascular Disease	0.3	0.8	3.2	1.5	-1.8	-1.5	1.1	1.1	0.2	0.1	1.0	0.6	-0.2	1.2	0.9	0.1	0.1	0.7	1.1	0.6	0.2	-0.4	1.1	-0.3	1.6	-0.1	0.7	0.2
Hypothyroidism (self reported)	0.3	0.7	2.9	-0.4	-1.3	-1.3	0.8	0.5	0.2	0.3	0.8	0.4	-0.4	1.1	1.1	-0.3	0.1	0.2	0.8	0.3	0.4	-1.7	0.7	-0.6	1.6	-0.0	1.3	0.3
Supplements: Zinc	0.3	0.4	1.5	-0.4	0.3	0.8	-1.0	0.1	-0.1	-0.1	-0.8	-0.8	-0.3	-0.7	-0.4	-0.3	-0.3	0.0	-1.2	-0.4	-0.1	-1.0	-1.2	0.3	-0.5	-0.2	-0.7	-0.2
Medication: Co-codamol	0.3	0.4	2.2	-0.6	0.1	0.4	-0.6	-0.4	-0.7	-0.4	-1.3	-0.6	0.2	-0.8	-0.7	0.4	-0.1	0.2	-0.6	-1.5	-0.3	0.5	-0.5	-0.8	0.1	0.0	-1.0	-0.1
Fed-up feelings	0.3	0.5	2.0	1.0	0.4	0.1	-0.1	0.7	0.8	0.6	0.4	0.7	0.8	-0.1	0.1	0.9	0.7	1.4	0.3	0.6	0.6	1.3	0.2	0.9	-0.0	0.7	-0.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	0.9	-0.5	-0.4	0.1	0.3	0.4	0.3	0.0	0.4	1.0	0.6	0.4	1.1	0.8	-0.1	0.4	0.7	0.4	0.9	0.4	0.1	0.8	0.8	-0.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.5	-0.4	0.8	0.2	0.0	0.7	0.5	0.4	1.0	0.6	0.6	0.1	0.1	0.6	0.5	1.2	0.6	0.2	0.4	0.5	0.3	0.5	0.5	0.5	0.2	0.3
High blood pressure	0.3	0.9	2.8	0.9	-1.7	-1.3	1.1	1.3	-0.4	0.3	1.3	0.7	-0.4	1.4	1.2	-0.2	0.0	0.4	1.0	1.5	0.5	-0.5	0.9	-0.5	1.1	-0.1	0.9	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.2	0.4	0.8	0.7	-0.2	-0.9	-1.0	-1.0	-0.9	-0.7	-0.7	-1.2	-1.3	-0.7	-0.9	1.0	-0.0	-1.5	-1.0	-0.0	-0.2	0.1	-1.0	-0.9	-0.4	-1.0
Supplements: Glucosamine	0.3	0.4	1.7	-0.0	-0.3	-0.2	0.7	0.3	-1.3	-0.2	0.3	-0.2	-0.7	0.0	0.0	-0.5	-0.5	0.5	0.7	-0.5	-0.4	-1.3	0.7	-1.3	0.1	-0.6	0.3	-0.5
Allergy	0.3	0.6	2.7	0.6	-0.8	-0.7	0.6	0.7	1.0	0.8	0.8	0.6	0.3	1.4	1.3	0.4	0.7	-0.5	0.4	1.6	0.8	-0.7	0.6	-0.1	0.8	0.5	1.0	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	4.8	0.5	0.3	-0.0	-0.1	0.0	0.7	0.3	-0.4	0.3	0.8	-0.2	-0.2	0.9	0.6	1.3	0.4	-0.3	0.2	2.2	0.3	0.6	-0.5	0.6	0.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.9	1.5	-1.1	-0.4	-0.3	1.1	-0.3	0.6	0.4	0.3	-0.3	0.5	0.8	-0.1	0.1	-0.2	-0.3	1.7	0.6	0.6	-0.4	1.1	0.3	0.1	0.1	0.5
Illnesses of mother	0.3	0.4	2.5	0.1	-1.6	-0.9	-0.3	0.7	1.1	0.5	0.6	0.4	-0.1	0.6	0.8	0.1	0.3	-0.2	-0.6	0.9	0.6	-0.2	-0.3	0.1	0.6	0.2	0.7	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	2.4	-1.6	1.0	0.7	-0.5	0.2	-0.8	-0.1	-0.2	-0.0	0.3	-0.5	-0.5	0.6	0.1	0.1	-0.3	0.1	-0.0	0.9	-0.5	0.1	-1.0	0.1	-0.8	0.0
Hair/balding pattern: Pattern 4	0.3	0.7	2.0	0.8	-0.3	-1.0	0.9	0.7	-0.3	0.5	0.9	0.9	0.5	1.3	1.3	0.6	0.8	-0.6	0.6	0.8	1.0	0.1	0.9	0.0	0.6	0.7	1.4	1.1
Medication: Amlodipine	0.3	0.4	1.3	-0.2	0.9	0.9	-1.1	-0.0	-0.2	-0.3	-0.7	-0.7	-0.5	-0.9	-0.8	-0.3	-0.6	0.1	-0.8	-0.0	-0.5	-0.1	-1.1	0.4	-0.8	-0.5	-0.8	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.6	-0.6	0.6	0.7	-1.6	0.1	0.3	0.6	-0.5	-0.3	-0.1	-0.8	-0.3	-0.2	-0.0	-0.9	-0.9	0.3	0.4	-0.5	-1.2	-0.6	0.8	0.1	-0.1	0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	2.5	-1.0	-0.9	-0.7	-0.3	-0.0	0.6	0.6	0.1	0.2	-0.2	0.7	0.9	-0.5	0.2	-1.5	-0.3	0.8	0.6	-0.2	-0.1	-1.4	1.0	0.2	1.6	0.6
Alcohol intake frequency.	0.3	0.8	4.2	-0.4	2.0	0.9	1.1	-0.2	-1.7	-0.6	0.4	0.1	0.3	-0.3	-0.4	0.4	-0.0	1.9	1.2	-1.3	-0.3	0.0	0.8	0.1	-0.8	-0.0	-1.2	-0.2
Long-standing illness, disability or infirmity	0.3	0.4	1.7	0.5	-0.6	-0.7	0.7	1.0	0.0	0.4	1.0	0.5	-0.1	0.6	0.6	-0.1	0.1	0.7	0.7	0.7	0.4	1.3	0.5	0.9	0.2	0.1	0.9	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	0.2	0.5	0.8	-1.0	-0.3	-1.1	-0.2	-0.4	-0.7	-0.8	-0.7	-0.6	-0.9	-0.7	-0.6	-0.8	0.7	-0.4	-0.3	-1.1	0.7	-0.5	-0.6	-0.3	-0.6
Ever smoked	0.3	0.4	1.5	0.7	-0.6	-0.8	0.9	0.4	0.3	0.2	0.4	0.7	0.5	0.5	0.4	0.6	0.5	0.2	1.2	-0.0	0.2	0.1	1.1	-1.2	1.2	0.4	0.9	0.3
Ulcerative Colitis (UC)	0.2	0.3	1.4	0.7	0.9	0.5	-0.6	0.5	0.4	0.2	-0.4	-0.1	0.5	-0.3	-0.3	0.5	0.3	0.6	-0.7	-0.2	0.0	0.7	-0.5	1.2	-0.3	0.3	-0.9	0.1
LDL Cholesterol	0.2	0.3	2.1	0.0	0.4	0.6	-0.5	-0.3	-0.3	-0.2	-0.6	-0.3	0.3	-0.8	-0.7	0.3	-0.0	-0.3	-0.2	0.3	-0.3	0.6	-0.4	0.6	-0.7	0.1	-1.4	-0.3
Lupus	0.2	0.3	2.9	0.3	0.1	-0.2	-0.3	-0.2	0.1	0.1	-0.0	0.0	0.1	0.2	0.0	0.0	0.0	-1.1	-0.2	-0.0	-0.0	0.8	-0.2	1.7	-0.6	0.0	-1.1	-0.0
Ulcerative Colitis	0.2	0.3	3.5	0.5	0.7	0.5	0.3	-0.7	0.0	-0.3	-0.3	-0.0	0.5	-0.2	-0.4	0.4	0.2	0.2	-0.5	-0.6	-0.2	1.9	0.1	0.8	-0.6	0.2	-0.8	-0.1
Blood Platelet Count	0.2	2.2	7.9	-2.8	-2.6	-2.0	1.3	1.2	0.9	1.0	1.3	1.2	-0.0	1.6	1.8	0.1	0.6	1.4	2.1	1.9	1.0	-0.8	1.2	0.6	1.5	0.4	2.1	1.0
Respiratory disease	0.2	0.5	4.3	-2.1	0.4	0.2	-0.6	0.6	-1.1	0.0	-0.3	-0.4	-0.6	-0.7	-0.3	-0.7	-0.4	-0.6	-0.5	-0.5	0.0	-1.2	-0.7	-1.4	0.2	-0.3	0.4	-0.1
Angina	0.2	0.3	0.9	0.2	0.8	0.7	-0.5	0.1	-0.4	-0.0	0.0	-0.1	0.1	-0.8	-0.6	0.3	-0.1	-0.8	-0.6	-0.8	0.1	0.0	-0.6	0.9	-0.2	0.1	-0.9	0.0
Pack years adult smoking proportion	0.2	0.3	1.5	1.1	0.3	0.6	-1.1	0.3	0.3	-0.1	-0.5	-0.5	-0.1	-0.5	-0.2	0.1	-0.1	-0.1	-1.0	0.1	-0.0	0.3	-1.1	0.5	-1.2	-0.0	0.2	-0.0
Past tobacco smoking	0.2	0.3	2.1	-0.7	0.4	0.7	-0.7	-0.2	0.2	0.3	-0.4	-0.3	-0.1	-0.2	-0.1	-0.2	-0.0	-0.5	-0.9	0.7	0.2	0.2	-0.9	1.5	-1.3	0.1	-0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	2.0	1.1	-0.2	0.3	-0.6	-0.1	-1.0	0.1	-0.5	-0.1	0.4	-0.3	-0.3	0.4	0.2	-0.2	-0.2	0.4	-0.0	1.4	-0.3	-0.1	-0.2	0.2	-0.2	-0.0
Hair/balding pattern: Pattern 2	0.2	0.3	1.4	-0.3	-0.5	-0.3	-1.2	0.6	0.7	0.6	0.2	-0.2	-0.3	-0.1	0.1	-0.4	-0.1	-0.5	-0.7	0.2	0.2	-1.1	-0.9	-0.2	0.2	-0.1	0.7	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.8	-0.1	-0.2	-0.7	0.1	0.5	0.7	0.2	0.2	0.0	-0.4	0.4	0.3	-0.3	-0.2	0.1	0.5	0.8	-0.1	0.1	0.2	0.4	0.3	-0.3	1.3	-0.2
Lung cancer (father)	0.2	0.3	1.1	-0.0	0.1	0.4	-0.5	-0.7	0.6	-0.6	-0.2	-0.5	-0.7	-0.3	-0.3	-0.5	-0.6	0.0	-0.8	-0.7	-0.5	-0.0	-0.6	-1.0	-0.0	-0.6	0.2	-0.5
Length of working week for main job	0.2	0.2	3.1	0.3	-1.0	-0.4	0.4	0.4	-0.1	-0.1	-0.1	0.0	-0.4	0.0	0.2	-0.3	-0.2	0.3	0.1	-0.3	0.1	-1.8	0.3	0.1	0.6	-0.2	-0.5	0.2
Birth weight of first child	0.2	0.4	1.7	-0.8	1.1	0.6	-0.7	-0.1	0.2	0.1	-0.9	-0.3	0.8	-0.7	-0.7	0.8	0.4	0.2	-0.5	-1.3	-0.1	0.7	-0.4	-0.0	-0.5	0.5	-0.6	-0.1
Medication: Paracetamol	0.2	0.3	3.2	0.7	-0.1	0.1	-0.1	0.5	-0.5	0.1	0.2	0.2	0.4	-0.2	-0.2	0.5	0.3	1.8	-0.1	0.1	0.1	-0.0	-0.1	1.1	0.1	0.3	-0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.8	-1.0	-0.9	0.9	0.2	0.1	0.0	0.3	0.1	-0.5	0.8	0.8	-0.4	-0.2	-0.3	0.7	0.1	0.1	-1.1	0.7	-0.5	1.0	-0.3	1.0	0.0
Number of children fathered	0.2	0.2	1.2	1.1	-0.2	-0.1	0.3	0.7	0.3	0.2	0.0	0.1	0.1	0.2	0.1	0.1	0.1	0.9	-0.0	0.7	-0.0	0.8	0.2	0.0	-0.2	0.0	0.9	0.0
Neck or shoulder pain in last month	0.2	0.3	1.7	0.8	0.3	0.2	-0.1	0.7	0.2	0.2	0.0	0.4	0.7	-0.1	0.0	0.8	0.5	0.7	0.5	0.3	0.3	1.2	0.0	1.3	-0.6	0.6	-0.5	0.4
Angina (self-reported)	0.2	0.3	1.7	0.2	0.8	0.6	-0.7	0.3	-0.3	0.1	0.1	-0.0	0.3	-0.7	-0.5	0.4	0.1	-0.9	-0.7	-0.6	0.3	0.5	-0.8	1.3	-0.3	0.3	-0.9	0.2
Migraine (self-reported)	0.2	0.2	1.2	0.7	-0.4	-0.1	-0.1	0.6	-0.1	0.3	0.2	0.2	0.4	-0.4	-0.3	0.4	0.3	0.5	-0.1	1.1	0.1	-0.1	-0.0	1.0	0.1	0.3	-1.0	-0.0
Heart disease (mother)	0.2	0.2	1.0	-0.2	0.6	0.6	-0.1	-0.5	-0.1	-0.1	-1.0	-0.4	0.2	-0.6	-0.7	-0.0	-0.0	-0.3	-0.0	-0.6	-0.3	-0.4	-0.1	-0.3	-0.8	0.0	-0.3	-0.4
Age at last live birth	0.2	0.3	2.8	-0.8	0.4	0.7	-0.0	-0.5	0.0	-0.6	-0.4	-0.4	-0.2	-0.2	-0.5	-0.2	-0.3	-0.3	-0.1	0.7	-0.6	0.3	-0.2	0.6	-1.7	-0.4	-0.1	-0.6
Family relationship satisfaction	0.2	0.2	2.9	1.7	0.5	0.7	-0.1	-0.4	0.5	-0.1	-0.1	-0.1	0.2	-0.2	-0.3	0.2	0.0	-0.2	-0.1	0.2	-0.2	-0.5	-0.1	0.1	0.3	0.0	-0.5	-0.1
Illnesses of father: Heart disease	0.2	0.3	0.9	1.0	-0.5	0.2	-0.2	0.2	-0.7	-0.1	-0.5	-0.3	-0.3	-0.2	-0.4	-0.2	-0.4	0.4	0.1	0.9	-0.5	1.0	-0.0	1.0	-0.5	-0.4	-0.3	-0.6
Smoking status: Previous	0.2	0.3	1.3	0.7	-0.5	-0.8	0.7	0.3	-0.1	-0.1	0.7	0.6	0.3	0.3	0.3	0.4	0.2	0.0	0.9	-0.4	0.1	-0.1	0.8	-0.6	1.1	0.1	0.3	0.2
Friendships satisfaction	0.2	0.2	0.7	0.6	0.5	0.3	0.2	-0.8	-0.6	-0.6	-0.1	-0.5	-0.4	-0.2	-0.4	-0.5	-0.5	-0.3	-0.2	-0.4	-0.6	-0.7	-0.0	-0.5	-0.6	-0.5	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	-0.9	0.3	0.0	-0.8	-0.5	-0.5	-0.4	-0.1	-0.1	0.2	-1.0	-0.7	0.5	-0.0	0.4	-0.6	-0.8	-0.0	0.6	-0.7	1.0	0.0	0.1	-0.3	0.1
Mineral and other dietary supplements	0.2	0.3	2.5	-0.5	0.3	-0.1	-0.6	0.1	0.6	0.3	0.1	0.1	0.1	0.1	0.1	0.2	0.2	-0.5	-0.4	1.1	0.2	1.1	-0.6	1.6	-0.7	0.2	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.1	0.2	-0.1	-0.5	0.5	0.2	-0.3	0.6	1.1	0.7	0.4	0.7	0.8	0.3	0.6	0.5	0.4	1.4	0.7	-0.2	0.4	1.1	0.4	0.5	1.0	0.7
Guilty feelings	0.2	0.3	1.4	0.5	-0.4	-0.3	-0.4	1.0	-0.1	0.9	0.3	0.4	0.2	0.2	0.5	0.3	0.4	-0.6	0.3	1.2	0.7	-0.6	-0.2	0.7	-0.4	0.4	0.6	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.1	0.6	-0.7	-0.5	0.6	0.5	-0.1	0.3	0.6	0.4	-0.0	0.5	0.5	-0.2	0.1	0.8	0.7	-0.0	0.3	-0.9	0.8	-0.6	1.1	0.1	0.5	0.3
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.6	-1.1	-0.7	0.8	-0.5	0.9	-0.5	-0.0	0.2	0.2	0.7	0.3	0.4	0.1	-0.3	0.3	0.5	-0.3	0.7	0.6	-0.5	0.4	0.0	-1.0	-0.1
Medication: Lisinopril	0.2	0.2	1.7	-0.6	-0.5	-0.3	-0.2	-0.1	-0.1	0.2	0.2	0.2	0.4	0.5	0.3	0.6	0.3	-0.5	-0.1	0.7	0.1	1.3	-0.1	-0.3	0.3	0.3	-0.6	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.6	0.3	0.8	0.9	-0.3	0.3	-0.1	0.0	-0.4	-0.3	0.1	-0.2	-0.3	0.0	0.0	0.8	-0.1	-0.2	-0.2	1.3	-0.3	0.2	-1.2	0.0	-0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.8	-0.9	1.3	1.1	-1.1	-1.1	0.6	-0.1	-1.1	-0.6	0.3	-1.1	-0.9	-0.0	-0.0	-0.4	-1.0	-1.0	-0.3	0.6	-1.0	0.8	-1.2	0.1	-0.6	-0.3
Pack years of smoking	0.2	0.3	1.7	1.1	0.3	0.4	-0.7	0.2	-0.1	-0.4	-0.4	-0.5	-0.5	-0.3	-0.1	-0.3	-0.4	-0.1	-0.8	0.1	-0.2	-0.2	-0.8	-0.0	-1.3	-0.3	0.3	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.8	1.3	0.3	-0.4	0.4	0.7	1.0	0.4	0.1	0.3	0.5	0.6	0.5	0.5	0.5	1.2	0.3	-0.1	0.3	-0.4	0.5	0.9	0.3	0.4	0.3	0.4
Lung FVC	0.1	0.4	2.0	0.1	-0.0	-0.6	0.8	-0.2	-0.4	0.0	1.0	0.5	-0.2	0.6	0.6	-0.2	0.0	0.3	1.0	0.6	0.2	-1.4	1.0	-0.5	0.8	-0.1	1.1	0.1
Tanning	0.1	0.7	3.4	-0.1	0.5	0.7	0.0	-0.0	0.3	-0.8	-0.3	-0.7	-0.8	-0.8	-1.0	-0.9	-0.9	1.8	-0.3	-1.5	-1.0	-0.7	-0.1	-1.2	-0.3	-0.9	-1.0	-1.0
Average weekly spirits intake	0.1	0.2	2.1	-1.5	-0.6	-0.6	-0.6	-0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.0	-0.0	0.1	-0.0	-0.1	-0.0	-0.2	0.1	-0.2	-0.2	-0.8	0.5	-0.0	0.6	0.0
Impedance of leg (right)	0.1	0.4	4.0	-1.2	0.7	0.2	-0.6	-0.8	0.0	-0.1	-0.3	-0.2	0.0	-0.4	-0.2	-0.0	-0.0	0.7	-0.5	-2.0	-0.0	-0.3	-0.5	-0.7	0.8	0.0	-0.0	-0.1
Impedance of leg (left)	0.1	0.3	1.5	-1.0	0.2	-0.2	-0.4	-0.4	0.5	0.3	0.1	0.2	0.4	0.0	0.2	0.4	0.4	1.1	-0.0	-1.2	0.4	-0.3	-0.2	-0.4	1.1	0.4	0.6	0.3
Medication: Simvastatin	0.1	0.2	1.0	0.6	-0.1	-0.0	0.7	0.0	0.1	-0.4	-0.1	-0.1	-0.1	-0.0	-0.3	-0.1	-0.2	1.0	0.6	-0.6	-0.4	-0.5	0.6	-0.5	0.2	-0.3	-0.0	-0.4
Arm fat percentage (right)	0.1	0.5	2.7	1.2	0.2	0.5	-0.5	-0.1	0.2	-0.4	-0.5	-0.0	0.7	-0.9	-0.9	0.8	0.2	1.2	-0.3	-1.4	-0.2	1.6	-0.4	0.5	-0.3	0.3	-0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	1.2	-0.1	0.6	0.1	-0.0	0.3	-0.0	0.2	-0.1	0.0	0.1	-0.2	-0.3	0.2	-0.0	1.1	0.5	-0.2	-0.2	0.7	0.1	-0.0	-0.4	-0.0	0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	1.3	0.9	-0.0	-0.2	-0.1	-0.4	0.5	-0.2	-0.1	0.2	0.3	0.0	-0.0	0.4	0.2	0.9	0.2	0.4	-0.0	0.2	0.1	-0.1	1.2	0.2	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.6	-0.5	0.1	0.3	0.2	-0.7	-0.5	-0.2	-0.5	-0.0	0.3	-0.0	-0.2	0.1	0.1	-0.8	-0.1	-0.5	-0.1	-0.4	0.3	0.2	0.1	0.1	-0.7	0.1
Arm fat percentage (left)	0.1	0.4	2.7	1.2	-0.3	0.2	-0.5	0.2	0.5	-0.2	-0.3	0.2	0.7	-0.6	-0.6	0.9	0.3	0.9	-0.2	-1.2	0.1	1.6	-0.4	0.7	0.0	0.4	-0.2	0.4
Loneliness, isolation	0.1	0.2	1.3	0.5	-0.1	-0.2	-0.4	0.7	-0.3	0.6	0.3	0.3	0.3	0.0	0.2	0.4	0.3	0.2	0.0	0.8	0.5	1.1	-0.2	0.7	-0.3	0.4	-0.3	0.4
Cholesterol lowering medication	0.1	0.1	0.4	-0.0	-0.2	-0.3	0.2	0.4	-0.7	-0.1	0.2	-0.0	-0.3	-0.2	-0.3	-0.1	-0.3	0.5	0.5	-0.5	-0.2	0.3	0.3	0.5	0.1	-0.3	-0.1	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	0.6	0.6	-0.6	-0.2	0.1	0.7	0.1	0.3	0.1	0.6	0.7	-0.0	0.2	0.8	0.6	0.2	0.6	0.1	0.6	-0.3	0.2	0.4	0.7	0.7	-0.7	0.8
Hair Pigment	0.0	1.2	4.0	1.5	-0.8	-0.7	0.1	0.9	2.0	1.2	0.6	1.1	1.7	0.9	1.0	1.9	1.5	0.2	0.3	0.8	1.3	0.7	0.3	0.5	0.7	1.6	0.1	1.5

Hub : Genes

LMF1

Models

Trait associations