Hub : Genes

LMO4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1510	0.0660	6.8e-03	0.000	NA	-0.003	NA	-0.002	3.2e-01	NA	6.5e-01	NA	0.44000
2	GTEx	Skin Sun Exposed Lower leg	0.1250	0.0440	1.6e-03	0.008	NA	0.045	NA	0.038	7.0e-02	NA	1.2e-04	NA	0.00042
3	METSIM	Adipose	0.0480	0.0209	9.2e-03	0.001	0.002	-0.002	0.002	-0.001	2.3e-01	1.3e-01	7.2e-01	1.3e-01	0.49000
4	YFS	Blood	0.0373	0.0120	3.4e-05	0.014	0.016	0.016	0.016	0.006	1.4e-05	3.4e-06	3.5e-06	2.9e-06	0.00430

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.0	-0.7	-1.1	1.4	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.3	-1.2	-1.5	0.5	-0.1
Depressed Affect (Nagel 2018)	4.4	9.3	27.4	0.8	2.8	5.2	1.4
Depression (Nagel 2018)	2.1	3.1	6.4	-0.3	1.6	1.9	2.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.1	0.1	0.6	-0.0	2.5
Neuroticism (Nagel 2018)	2.8	6.7	19.6	1.1	2.3	4.4	0.7
Schizophrenia (2018)	0.2	0.5	1.1	-0.9	-1.1	-0.3	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.7	-0.3	1.0	0.5
Worry (Nagel 2018)	1.0	2.1	7.3	0.4	0.6	2.7	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	0.7	1.1	-0.7	-0.5
Alzheimer’s Disease (in father)	0.6	0.7	1.8	0.4	0.3	-1.4	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	0.2	0.4	-1.0	-0.1
Crohns Disease (2017)	0.3	0.6	1.3	-1.0	-1.1	-0.4	-0.0
Irritable Bowel Disease (IBD)	0.8	2.0	3.6	-0.7	-1.8	-0.7	-1.9
Ulcerative Colitis (UC)	1.2	2.2	6.8	0.3	-1.1	-0.8	-2.6
Major Depression (MDD)	3.8	4.6	12.1	-2.1	0.5	3.5	1.3
Reaction Time	0.8	1.6	3.8	0.1	0.5	1.5	-1.9
Verbal and Numeric Reasoning (VNR)	0.5	1.1	3.9	0.0	-0.0	0.7	2.0
Breast Cancer	2.3	5.5	12.9	0.4	1.2	2.7	3.6
Ovarian Cancer	0.4	0.5	1.2	1.1	0.5	0.7	0.3
Prostate Cancer	0.1	0.2	0.4	0.2	0.5	-0.3	0.7
Age at First Birth	0.1	0.2	0.6	0.8	0.5	-0.2	-0.0
Bipolar Disorder (2011)	0.7	0.7	1.4	-0.2	-1.0	1.2	-0.5
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.4	0.3	-0.6	0.9
Coronary Artery Disease (CAD)	2.2	2.6	6.0	-0.0	1.0	-1.8	2.5
Crohns Disease (2012)	0.3	0.4	0.9	-0.7	-0.7	-0.9	-0.1
Mean Putamen Volume	0.8	0.9	2.7	0.9	1.6	0.0	0.0
Fasting Glucose	0.6	0.8	2.1	-0.6	-1.5	-0.7	0.0
HbA1C	1.1	1.2	3.4	1.1	0.4	0.2	-1.8
HDL Cholesterol	0.4	0.7	1.5	0.0	-0.7	-1.2	-0.8
LDL Cholesterol	0.2	0.3	0.9	-0.1	-0.4	0.9	0.1
Lupus	0.5	0.8	2.8	0.4	0.3	-0.3	-1.7
Neuroticism (2016)	1.4	2.0	6.2	-1.2	0.3	2.5	-0.6
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.5	-0.6	0.5	-0.9
Rheumatoid Arthritis	0.5	0.7	1.4	-0.9	0.3	0.6	-1.2
Schizophrenia (2014)	0.3	0.7	1.7	-0.1	0.1	1.1	1.3
Triglycerides	0.9	1.4	4.9	0.5	0.6	2.2	-0.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.8	0.9	0.6	-0.5	2.2
Ulcerative Colitis	2.5	3.7	12.0	-0.4	-1.6	-0.3	-3.5
Blood Eosinophil Count	0.1	1.1	2.9	0.1	-1.0	-1.7	0.6
Blood Platelet Count	0.1	1.3	2.9	-1.7	-0.1	1.2	0.9
Blood Red Count	0.2	1.5	5.2	-0.1	2.3	-0.2	-0.8
Blood White Count	0.0	0.3	0.6	-0.0	0.5	0.6	0.8
Heel T-Score	0.3	2.7	5.3	-2.3	-1.0	-1.8	1.1
BMI	0.6	3.4	9.9	-1.7	-0.6	0.5	3.1
Height	0.7	13.1	19.1	4.3	4.4	-2.9	-2.5
Waist Hip Ratio (WHR)	0.2	1.1	3.2	0.8	1.8	-0.6	0.2
Systolic Blood Pressure	0.9	4.3	8.0	2.1	0.0	-2.2	-2.8
Smoking Status	1.7	4.2	11.2	-0.7	1.9	3.4	1.2
Allergy or Eczema	0.2	0.6	1.2	0.1	-1.1	0.8	-0.6
Cardiovascular Disease	0.3	0.8	1.9	1.4	-0.1	-1.2	-0.2
Hypothyroidism (self reported)	0.9	2.2	4.1	1.8	2.0	-0.3	-1.2
Respiratory disease	0.2	0.5	1.2	1.1	0.4	0.7	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.8	1.4	1.2	0.4	0.7
Lung FEV1/FVC ratio	0.2	0.9	1.4	-1.2	0.6	-1.1	0.9
Lung FVC	0.0	0.2	0.6	0.2	-0.4	0.8	0.0
Neuroticism	1.9	4.5	14.5	0.6	1.8	3.8	-0.5
Chronotype (morning person)	0.2	0.3	1.0	-0.6	0.0	1.0	-0.1
Hair Pigment	0.0	0.4	1.2	-0.2	-1.1	0.2	-0.5
Tanning	0.1	0.7	2.0	0.8	0.4	-1.4	-0.3
Hand grip strength (left)	1.0	2.5	9.1	-0.3	-1.0	-3.0	-0.1
Number of treatments/medications taken	1.1	2.0	6.5	0.4	0.9	2.5	0.9
Average weekly spirits intake	0.7	0.9	1.7	-1.3	-0.6	1.3	0.1
Sensitivity / hurt feelings	1.0	1.7	3.0	1.1	1.7	1.5	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-0.3	1.1	0.9	0.3
Hearing difficulty/problems: Yes	0.6	0.9	2.3	-1.5	-0.0	0.6	0.9
Relative age of first facial hair	0.1	0.3	0.7	0.6	-0.3	0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	-1.0	-1.3	-0.2	-0.1
Ever used hormone-replacement therapy (HRT)	2.3	3.0	9.5	1.6	3.1	-0.0	-0.1
Ever had hysterectomy (womb removed)	1.0	1.1	2.6	-0.8	0.0	1.6	1.1
Systolic blood pressure, automated reading	0.4	1.2	2.8	0.3	0.1	-1.4	-1.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.7	-0.5	-0.3	0.4	1.3
Angina	1.7	2.2	7.9	0.6	0.5	0.5	-2.8
Medication for hormone replacement therapy	3.3	3.7	8.8	3.0	2.4	-0.3	0.7
Vitamin and mineral supplements	1.2	1.7	4.4	0.0	0.6	2.1	1.4
Supplements: Zinc	1.7	1.8	2.7	1.1	1.7	1.3	1.3
Medication: Co-codamol	0.2	0.2	0.4	-0.1	-0.4	0.6	0.5
Medication: Metformin	0.4	0.5	1.4	0.5	-0.5	-0.5	1.2
Diabetes (father)	1.1	1.4	3.6	-1.4	0.2	1.9	-0.1
Diabetes (mother)	2.0	2.5	7.9	1.4	2.8	0.4	0.3
Severe depression (siblings)	1.0	1.1	2.2	-1.3	-1.5	0.7	-0.2
Pack years adult smoking proportion	0.2	0.2	0.6	-0.2	0.5	-0.8	-0.1
Impedance of leg (right)	1.1	5.4	11.6	1.6	2.7	-0.3	-3.4
Leg fat-free mass (left)	0.3	1.4	4.4	0.3	-0.3	-1.1	2.1
Trunk fat percentage	0.3	1.3	2.7	-1.6	-0.3	1.4	0.5
Hand grip strength (right)	2.0	5.3	18.0	-0.7	-1.4	-4.2	-0.9
Townsend deprivation index at recruitment	1.5	2.1	4.8	-2.2	-1.7	-0.8	0.4
Current tobacco smoking	0.3	0.6	1.0	-0.7	1.0	0.8	0.1
Average weekly fortified wine intake	0.6	0.7	1.7	-0.7	-1.3	0.2	0.8
Maternal smoking around birth	0.7	1.1	3.0	1.1	1.7	0.4	-0.1
Fed-up feelings	3.5	6.3	22.8	-0.1	1.5	4.8	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	1.8	-0.9	0.8	1.3	0.5
Relative age voice broke	0.2	0.3	0.6	0.2	-0.6	0.8	0.3
Taking other prescription medications	1.1	1.7	5.4	-1.1	0.3	2.3	0.4
Age when periods started (menarche)	0.2	0.4	0.9	0.2	0.1	0.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.3	-0.2	0.4	1.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.4	1.6	1.0	-1.8	0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.1	-0.4	-0.4	2.0	-0.2
Qualifications: CSEs or equivalent	1.1	1.5	3.9	-0.4	0.7	-2.0	-1.2
Serious illness, injury or assault to yourself	0.8	0.9	2.0	-0.5	-0.9	-1.4	-0.7
High blood pressure	0.2	0.7	2.6	1.6	-0.2	0.4	-0.0
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.5	-1.2	-0.8	0.5	-1.2
Multivitamins +/- minerals	0.6	0.7	1.9	0.0	-0.6	-1.4	-0.8
Stomach or abdominal pain in last month	1.5	1.9	4.4	-1.0	-1.1	1.0	-2.1
Supplements: Glucosamine	0.6	0.7	1.2	1.1	0.8	0.6	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	-0.1	-1.1	-0.5	-0.2
Medication: Atenolol	1.5	1.9	3.4	0.5	-1.8	-1.2	-1.6
Medication: Levothyroxine sodium	0.7	1.2	2.5	1.6	0.9	-0.6	-1.0
Sitting height	0.1	1.0	1.9	1.4	0.9	-1.1	0.4
Chronic bronchitis/emphysema (father)	1.7	1.9	5.5	1.2	2.4	-0.7	0.5
High blood pressure (mother)	0.4	0.5	0.7	-0.5	0.8	0.7	0.9
Body mass index (BMI)	0.6	2.5	4.1	-1.8	-1.3	1.0	2.0
Impedance of leg (left)	1.0	5.1	16.4	0.5	1.9	-0.5	-4.0
Leg predicted mass (left)	0.3	1.5	4.5	0.3	-0.3	-1.1	2.1
Trunk fat mass	0.2	0.9	1.6	-1.3	-0.3	0.9	1.0
Waist circumference	0.3	1.0	1.8	-1.3	-0.6	-0.2	1.3
Number of incorrect matches in round	1.5	2.5	3.7	-1.9	-1.9	0.3	-1.6
Past tobacco smoking	2.1	3.9	10.8	0.3	-1.5	-3.3	-1.5
Alcohol usually taken with meals	1.3	2.1	5.0	-0.2	-1.7	-2.2	0.6
Nervous feelings	0.7	1.4	2.9	-0.9	-0.7	1.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	0.2	0.7	1.4	-0.2
Hearing difficulty/problems with background noise	1.1	1.7	3.0	-1.6	0.1	1.1	1.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	-0.6	0.4	-0.3	0.9
Had menopause	1.9	2.4	5.0	1.8	2.2	1.2	0.1
Had other major operations	0.4	0.5	1.1	1.0	0.5	-0.3	-0.7
Forced vital capacity (FVC)	0.0	0.1	0.2	0.3	-0.1	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.6	1.6	0.9	-1.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.8	-0.3	0.9	-0.0	0.1
Qualifications: None of the above	0.4	0.9	2.1	-0.3	1.1	1.5	-0.6
Financial difficulties in last 2 years	0.5	0.7	1.2	-0.1	-1.1	-0.5	-1.1
Mouth/teeth dental problems	0.7	1.1	3.2	1.8	0.4	-0.1	-1.1
Heart attack	0.7	0.9	1.8	0.2	-0.7	-1.3	1.1
Allergy	0.3	0.8	1.5	1.2	-0.2	-1.2	0.6
Pain all over the body in last month	0.9	0.9	1.7	0.4	1.3	1.2	0.6
Diabetes (self-reported)	0.2	0.3	0.6	0.5	0.5	-0.7	0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.8	-1.9	-1.5	0.7	0.4
Medication: Ramipril	1.6	2.1	7.0	0.7	-0.7	-2.6	0.4
Medication: Simvastatin	0.4	0.5	0.9	0.6	0.9	-0.4	1.0
Fluid intelligence score	0.3	0.6	1.5	-0.2	-0.6	1.2	0.8
Illnesses of siblings	1.5	2.1	4.2	2.1	1.8	0.9	0.4
Neuroticism score	1.4	2.9	9.1	-0.4	1.3	3.0	-0.8
Weight	0.1	0.6	1.5	-0.7	-0.5	-0.5	1.2
Impedance of arm (right)	0.4	1.7	4.8	0.4	1.3	0.3	-2.2
Arm fat percentage (right)	0.6	2.3	4.1	-2.0	-1.0	1.3	1.5
Trunk fat-free mass	0.4	2.5	5.3	1.1	0.3	-2.3	1.9
Hip circumference	0.4	1.5	2.5	-1.2	-1.6	-0.7	1.4
Time employed in main current job	2.1	2.4	3.5	1.9	1.6	-1.0	1.6
Alcohol intake versus 10 years previously	0.8	1.2	2.5	-1.1	-0.1	1.1	1.6
Father’s age at death	0.6	0.9	1.7	-1.3	-1.3	0.3	-0.2
Worrier / anxious feelings	0.8	1.6	4.5	-0.9	-0.9	2.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.2	-1.5	-0.2	2.3	1.0
Falls in the last year	0.1	0.2	0.2	0.3	-0.5	0.4	0.4
Hair/balding pattern: Pattern 3	0.2	0.4	0.9	0.7	-0.9	0.2	-0.3
Number of live births	1.0	1.5	4.8	-0.4	-0.3	0.8	-2.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.7	0.7	0.8	-0.6	0.6
Pulse rate	4.3	7.2	11.5	-3.3	-3.4	1.9	1.6
Happiness	0.2	0.3	0.4	-0.6	-0.6	0.7	-0.1
Noisy workplace	0.1	0.1	0.3	-0.0	0.5	-0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.0	1.7	-0.1	-0.8	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.6	0.1	-1.6	0.6	0.2
Mouth/teeth dental problems: Dentures	0.6	1.0	3.3	-0.5	0.6	0.5	1.8
Asthma	0.2	0.4	0.8	0.0	0.9	0.9	-0.0
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	5.6	0.9	1.6	2.4	1.9
Medication: Cholesterol lowering	0.5	0.7	1.3	0.2	-1.1	0.6	1.1
Depression (self-reported)	2.3	2.8	8.8	-0.3	0.7	3.0	1.3
Medication: Lansoprazole	1.2	1.4	2.5	1.4	1.6	-0.7	-0.7
Prospective memory result	0.1	0.1	0.3	-0.1	0.0	-0.5	0.0
Lung cancer (father)	0.6	0.7	2.2	0.1	0.5	1.5	0.7
Illnesses of mother	1.6	2.0	4.0	-1.7	-2.0	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.0	0.6	1.0	-0.5	0.8
Pulse wave Arterial Stiffness index	2.3	2.7	4.4	2.1	1.6	-0.7	1.9
Impedance of arm (left)	0.6	2.9	8.0	0.8	1.3	1.2	-2.8
Arm fat mass (right)	0.4	1.8	3.6	-1.5	-0.8	0.7	1.9
Trunk predicted mass	0.5	2.6	5.3	1.1	0.4	-2.3	2.0
Standing height	0.5	4.8	8.5	2.4	1.9	-2.9	-1.2
Length of working week for main job	0.8	0.9	3.2	-1.8	-0.4	-0.1	0.5
Exposure to tobacco smoke at home	1.7	1.9	3.7	-0.3	1.9	1.9	0.6
Breastfed as a baby	1.1	1.4	3.9	0.4	-1.2	-0.3	2.0
Tense / ‘highly strung’	1.2	1.9	3.9	0.5	1.9	0.0	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	6.0	0.4	1.3	2.5	2.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	-0.5	-0.0	1.3	0.5
Birth weight of first child	0.5	0.8	1.3	-1.1	0.1	1.1	0.8
Peak expiratory flow (PEF)	1.1	2.6	4.2	1.6	1.7	-0.7	2.0
Pulse wave reflection index	3.1	3.8	7.7	2.8	2.4	-1.3	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.5	-0.7	-0.6	0.6	0.4
Loud music exposure frequency	1.2	1.3	4.3	-0.4	0.7	0.6	-2.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.9	1.7	0.8	0.0	1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	-0.8	-0.7	-0.3	-0.8
Blood clot in the leg (DVT)	1.0	1.3	4.8	0.2	0.6	2.2	0.3
Medication: Paracetamol	1.5	2.4	6.2	-1.9	-0.0	2.5	-0.0
Headache pain in last month	3.3	5.7	16.5	-1.5	-0.8	4.1	1.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	3.5	-0.2	1.8	-1.9	-1.5
Glaucoma (self-reported)	0.6	0.7	1.9	0.5	0.2	0.7	-1.4
Gout (self-reported)	1.1	1.4	5.4	2.3	0.1	0.6	-0.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.2	3.5	1.9	1.4	-1.0	-1.6
Medication: Amlodipine	1.0	1.4	3.4	1.2	0.3	-1.8	0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	-0.1	-0.0	0.5	-0.7
Birth weight	0.2	0.4	1.6	1.3	0.1	-0.2	0.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.3	0.6	-0.3	-0.0	-2.1
High blood pressure (siblings)	1.0	1.4	3.0	-1.7	-1.5	-0.5	-0.7
Forced vital capacity (FVC), Best measure	0.0	0.2	0.4	0.5	0.6	-0.2	0.1
Body fat percentage	0.3	1.3	2.5	-1.6	-0.4	1.4	0.6
Leg fat percentage (right)	0.2	0.6	1.3	-1.1	-0.3	0.8	0.5
Arm fat-free mass (right)	0.3	1.6	2.8	0.9	0.1	-1.7	1.7
Exposure to tobacco smoke outside home	1.8	2.4	6.7	-1.4	-2.6	-0.1	-0.9
Comparative body size at age 10	0.8	2.3	7.4	-1.1	0.6	0.0	2.7
Number of full brothers	0.7	0.8	2.3	-0.6	-0.1	-1.5	-0.8
Worry too long after embarrassment	0.4	0.7	2.0	0.6	1.4	0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	7.5	-2.0	0.4	2.5	2.7
Wheeze or whistling in the chest in last year	0.3	0.6	1.8	0.3	1.4	0.5	-0.6
Number of children fathered	0.6	0.7	1.5	0.2	1.0	1.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	1.2	-0.5	-1.1	-1.1	0.6
Age at first live birth	0.7	1.3	3.2	-0.8	-1.8	-0.3	-1.1
Pulse wave peak to peak time	2.1	2.5	4.2	-1.9	-1.4	0.4	-2.1
Health satisfaction	0.1	0.1	0.2	-0.1	0.5	0.4	-0.4
Shortness of breath walking on level ground	1.2	1.5	2.4	1.1	1.5	1.0	1.2
Qualifications: College or University degree	0.9	2.7	6.3	1.9	-0.2	-0.9	2.5
Eye problems/disorders: None of the above	0.4	0.4	1.1	-0.6	0.2	1.1	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.1
Emphysema/chronic bronchitis	0.9	1.1	2.8	0.1	1.2	-1.7	-0.3
Medication for pain relief, constipation, heartburn	2.8	4.8	11.6	0.8	-0.4	-3.4	-2.6
Neck or shoulder pain in last month	1.8	2.5	9.0	0.2	0.4	3.0	-1.0
Medication: Blood pressure	1.0	1.8	4.1	0.4	-2.0	1.5	0.7
Angina (self-reported)	1.2	1.5	5.5	0.6	0.3	0.4	-2.3
Migraine (self-reported)	1.2	1.5	4.7	0.2	0.5	2.2	1.1
Medication: Ibuprofen	2.7	3.2	6.7	0.8	1.1	2.6	2.1
Medication: Allopurinol	1.9	2.5	5.8	2.4	1.4	1.5	0.0
Medication: Omeprazole	1.3	1.6	2.9	-1.7	-1.6	1.0	-0.3
Medication: Seretide 50 evohaler	1.1	1.3	1.8	1.4	0.7	1.1	-1.3
Mean time to correctly identify matches	1.2	2.2	6.7	1.1	0.4	0.9	-2.6
Heart disease (mother)	0.5	0.6	1.7	1.3	0.5	0.7	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.0	0.5	1.0	-1.0
Whole body fat mass	0.2	1.0	1.6	-1.3	-0.6	0.7	1.2
Leg fat mass (right)	0.1	0.6	1.3	-0.9	-0.5	0.2	1.1
Arm predicted mass (right)	0.3	1.6	3.3	0.8	0.3	-1.6	1.8
Pulse rate, automated reading	2.7	8.7	18.6	-2.2	-0.4	4.3	3.4
Alcohol intake frequency.	0.7	1.7	5.6	-1.0	-0.3	2.4	-0.3
Comparative height size at age 10	0.4	2.4	6.8	0.0	1.7	-2.6	-0.3
Number of full sisters	0.7	0.8	2.1	-1.5	0.5	-1.0	0.0
Suffer from ‘nerves’	0.7	1.2	3.0	-0.2	-0.1	1.7	-1.2
Overall health rating	1.1	2.3	5.0	-1.8	-0.7	2.2	-0.8
Chest pain or discomfort	2.1	3.1	4.0	-1.4	-1.6	2.0	-1.9
Had major operations	0.6	0.7	1.2	-0.4	0.2	-1.1	1.1
Age at last live birth	1.2	1.7	3.0	-1.3	-1.5	1.7	-0.3
Family relationship satisfaction	1.0	1.3	4.5	-0.1	-2.1	0.2	-0.8
Leg pain on walking	0.1	0.2	0.2	-0.5	0.5	-0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.3	-0.8	-0.9	-1.4	-1.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	0.4	1.3	-0.4	0.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.3	-0.6	0.6	1.3	1.5
Medication: Aspirin	1.0	1.3	2.7	1.6	-0.0	-0.7	1.5
Supplements: Vitamin C	0.2	0.3	0.8	0.5	0.0	-0.9	-0.1
Knee pain experienced in last month	1.2	1.9	3.6	0.5	1.7	1.9	1.0
Hypertension (Self-reported)	0.3	0.8	2.0	1.4	-0.6	0.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.5	-1.1	-1.4	1.9	-0.3
Illnesses of father: Heart disease	0.6	0.8	2.1	0.7	-0.0	-1.4	0.9
Illnesses of siblings: Diabetes	0.7	0.9	2.6	0.5	0.8	-0.4	-1.6
Smoking status: Previous	1.8	2.7	7.4	0.2	1.4	2.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	7.6	1.8	1.4	-2.8	-0.6
Whole body fat-free mass	0.4	2.1	4.2	0.7	-0.0	-1.9	2.0
Leg fat-free mass (right)	0.3	1.4	3.5	-0.1	-0.7	-1.3	1.9
Arm fat percentage (left)	0.6	2.3	3.2	-1.8	-0.9	1.8	1.4
Average weekly red wine intake	2.7	4.0	13.1	1.3	-1.0	-3.6	-0.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.6	-1.0	0.7	-0.2	1.9
Mood swings	2.2	4.0	14.0	-0.6	1.2	3.7	0.6
Loneliness, isolation	1.2	1.7	3.0	-0.3	1.5	1.7	1.2
Long-standing illness, disability or infirmity	1.2	1.9	7.4	-0.1	0.3	2.7	-0.3
Ever had bowel cancer screening	0.9	1.0	2.7	-0.0	-1.6	-0.9	-0.8
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.2	-0.0	-0.0	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.2	0.4	-0.4	-0.8
Friendships satisfaction	0.5	0.6	1.8	-0.0	-0.6	1.3	0.6
Qualifications: nursing, teaching	0.5	0.8	1.8	0.9	-1.3	-0.6	-0.4
Commuting to job workplace: Walk	0.3	0.3	0.5	0.6	0.1	-0.7	-0.5
Eye problems/disorders: Cataract	0.5	0.6	1.6	0.7	-0.5	-1.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.2	-1.8	-0.4	1.5	1.0
Medication for cholesterol	1.2	1.8	3.2	-1.8	-1.1	1.0	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	10.4	0.5	3.2	1.3	1.8
Back pain experienced in last month	3.7	5.3	10.4	-3.2	-2.5	1.4	-1.6
Mineral and other dietary supplements	1.2	1.6	3.6	0.1	1.9	0.4	1.6
Breast cancer (self-reported)	1.1	1.3	2.4	0.5	0.9	-1.3	-1.5
Asthma (self-reported)	0.2	0.4	1.1	0.1	0.7	1.1	-0.0
Osteoporosis (self-reported)	2.1	2.6	5.9	-2.4	-0.6	0.5	1.9
Osteoarthritis (self-reported)	1.8	2.3	5.5	-0.3	0.9	2.3	1.8
Medication: Aspirin	0.7	0.9	1.7	1.2	-0.5	-0.5	1.3
Medication: Gliclazide	1.4	1.6	2.6	0.7	-1.0	-1.5	-1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	0.7	-0.0	1.4	-0.3
Smoking status: Current	0.6	0.9	1.8	-0.6	1.3	1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.6	0.1	0.0	0.5
Whole body water mass	0.3	1.9	3.8	0.6	-0.1	-1.8	2.0
Leg predicted mass (right)	0.3	1.4	3.3	-0.1	-0.7	-1.4	1.8
Arm fat mass (left)	0.3	1.4	2.8	-1.2	-0.6	1.0	1.7
Number of self-reported non-cancer illnesses	0.5	0.8	3.0	0.1	-0.4	1.7	0.3
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.2	-0.9	-0.7	0.4
Miserableness	3.1	5.3	18.1	-0.4	1.7	4.3	-0.2
Guilty feelings	0.3	0.5	0.7	-0.2	0.7	0.8	0.8
Wears glasses or contact lenses	0.3	0.3	0.7	0.6	-0.9	-0.2	-0.2
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.8	0.1	-0.6	-0.9
Hearing aid user	0.4	0.5	1.1	-0.7	-0.3	0.4	-1.0
Mother’s age at death	0.4	0.5	1.4	-0.6	0.4	0.2	-1.2
Financial situation satisfaction	0.1	0.2	0.3	0.1	-0.5	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.9	-0.6	0.5	-0.5
Commuting to job workplace: Public transport	1.9	2.2	6.3	-1.5	-2.5	0.6	-0.3
Eye problems/disorders: Glaucoma	0.9	1.0	2.3	0.3	0.1	1.3	-1.5
Medication: Blood pressure	1.4	2.7	5.1	0.8	0.4	-2.3	-2.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.6	-0.6	0.8	-0.5
Supplements: Fish oil (including cod liver oil)	2.8	3.6	7.5	-0.6	-2.7	-0.2	-2.5
High cholesterol (Self-reported)	0.4	0.7	2.2	0.2	-0.0	-0.7	1.5
Medication: Bendroflumethiazide	0.3	0.5	1.4	0.4	-0.4	0.4	-1.2
Medication: Paracetamol	1.3	2.0	4.0	-2.0	-0.2	1.9	0.7
Medication: Lisinopril	0.4	0.5	1.3	-0.5	0.2	0.7	-1.1
Medication: Atorvastatin	0.3	0.3	0.8	-0.2	-0.6	-0.9	0.2
Illnesses of father: High blood pressure	0.3	0.4	1.2	1.1	0.3	-0.6	-0.1
Alcohol drinker status: Never	0.6	0.7	1.2	-0.8	-1.1	-0.4	-1.0
Ever smoked	1.8	3.2	10.3	-0.6	0.3	3.2	1.4
Basal metabolic rate	0.3	1.7	3.8	0.4	-0.1	-1.7	1.9
Leg fat percentage (left)	0.3	0.9	2.8	-1.7	-0.6	0.7	0.1
Arm fat-free mass (left)	0.4	1.8	4.1	0.6	0.4	-1.6	2.0
Number of operations (self-reported)	0.1	0.2	0.3	0.6	0.3	-0.4	0.1
Average weekly beer plus cider intake	0.5	0.8	1.6	-0.9	-0.7	1.2	0.5
Irritability	2.0	3.3	9.8	-1.2	-1.1	3.1	0.9
Risk taking	0.8	1.2	3.8	0.8	0.7	-2.0	-0.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.5	0.7	0.4	0.7	-0.6
Fractured/broken bones in last 5 years	1.3	1.6	6.0	0.4	-0.0	-2.4	-0.7
Age started oral contraceptive pill	0.5	0.6	1.5	-0.1	-0.7	-1.2	-0.6
Diastolic blood pressure, automated reading	0.2	0.8	1.5	-1.2	1.0	0.7	-0.2
Ever depressed for a whole week	0.2	0.2	0.3	-0.5	0.2	-0.4	0.6
Unable to work because of sickness or disability	0.8	1.1	3.1	-0.6	-1.8	0.3	0.8
Commuting to job workplace: Cycle	1.0	1.2	2.5	1.3	1.6	-0.4	0.7
Myopia	0.5	0.8	1.6	1.2	-0.0	-1.3	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.3	-1.8	-0.0	-0.4	0.0
Cholesterol lowering medication	1.7	2.4	6.5	0.9	1.5	-2.5	0.5
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	5.8	-2.4	-1.8	1.9	0.4
Pain experienced in last month	2.9	4.8	14.6	1.7	0.3	-3.8	-1.3
Supplements: Calcium	0.4	0.4	1.2	0.0	0.3	0.6	1.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.6	-0.6	0.0	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	0.3	-0.5	-1.2	1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.7	0.3	0.8	2.2	0.5
Heart disease (siblings)	1.1	1.3	3.4	-1.0	-1.0	-1.8	0.2
Alcohol drinker status: Previous	0.6	0.7	2.8	-0.1	-0.1	1.7	0.1
Pack years of smoking	0.3	0.4	1.0	-0.4	0.6	-1.0	-0.1
Impedance of whole body	0.9	4.3	13.0	0.7	1.9	0.6	-3.6
Leg fat mass (left)	0.2	0.6	1.3	-1.1	-0.6	0.2	0.9
Arm predicted mass (left)	0.3	1.6	3.6	0.4	0.1	-1.6	1.9