Hub : Genes

LOC401397

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0420	0.0220	6.7e-03	0.030	0.016	0.013	0.019	0.022	1.3e-04	4.0e-03	9.3e-03	0.0018	9.9e-04
2	TCGA	Breast Invasive Carcinoma	0.0605	0.0227	6.6e-14	0.093	0.078	0.080	NA	0.093	1.6e-18	1.3e-15	5.2e-16	NA	2.1e-18
3	TCGA	Colon Adenocarcinoma	0.0680	0.0340	4.3e-03	0.007	0.019	-0.001	NA	0.007	1.2e-01	2.7e-02	3.7e-01	NA	1.2e-01
4	TCGA	Esophageal Carcinoma	0.3090	0.0910	2.9e-06	0.157	0.198	0.151	NA	0.177	1.1e-05	6.6e-07	1.7e-05	NA	2.9e-06
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0774	0.0293	4.4e-09	0.053	0.076	0.066	NA	0.063	1.4e-06	5.9e-09	6.7e-08	NA	1.3e-07
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0930	0.0430	8.7e-05	0.066	0.043	0.035	NA	0.067	1.3e-04	1.6e-03	4.1e-03	NA	1.1e-04
7	TCGA	Lung Adenocarcinoma	0.0219	0.0126	7.5e-03	0.022	0.013	0.016	NA	0.019	1.2e-03	1.0e-02	4.7e-03	NA	2.5e-03
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.0730	0.0380	1.8e-03	0.010	0.038	0.034	NA	0.019	6.1e-02	1.2e-03	2.4e-03	NA	1.8e-02
9	TCGA	Prostate Adenocarcinoma	0.0670	0.0258	5.1e-08	0.069	0.069	0.051	NA	0.059	1.1e-07	1.1e-07	5.0e-06	NA	8.3e-07
10	TCGA	Soft Tissue Sarcoma	0.0960	0.0520	1.3e-03	0.005	0.035	0.016	NA	0.021	1.4e-01	3.6e-03	3.6e-02	NA	2.0e-02
11	TCGA	Stomach Adenocarcinoma	0.0440	0.0230	2.6e-03	0.026	0.025	0.003	NA	0.027	5.5e-03	5.6e-03	1.7e-01	NA	4.7e-03
12	TCGA	Thyroid Carcinoma	0.1020	0.0340	7.3e-11	0.122	0.122	0.122	NA	0.121	6.6e-12	6.1e-12	6.5e-12	NA	7.6e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	5.1	8.1	11.8	3.1	-3.0	-3.2	-2.4	-2.5	-3.0	-2.7	-1.3	-3.4	-2.7	-3.0	-3.2
Bipolar Disorder or Schizophrenia	1.2	3.0	5.9	1.9	-2.0	-2.4	-1.1	-1.3	-2.0	-1.3	0.3	-2.2	-1.2	-2.0	-2.0
Depressed Affect (Nagel 2018)	0.8	1.7	3.3	1.0	-1.5	-1.7	-0.6	-1.5	-1.5	-0.4	-1.2	-1.6	0.1	-1.8	-1.4
Depression (Nagel 2018)	0.3	0.4	1.7	-0.2	-0.2	-1.1	0.9	0.4	-0.2	0.7	1.3	-0.6	0.4	-0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.8	1.0	-0.8	-0.4	-0.6	-1.0	-0.8	-1.0	-1.1	-1.1	-1.3	-0.1	-0.5
Neuroticism (Nagel 2018)	0.4	1.0	1.6	0.7	-1.1	-1.1	-1.1	-1.2	-1.1	-0.4	-1.1	-1.0	0.4	-1.1	-1.3
Schizophrenia (2018)	0.1	0.3	1.9	-0.1	-0.2	-0.6	0.5	0.3	-0.2	0.5	1.4	-0.0	0.7	-0.2	0.1
Schizophrenia vs Biploar Disorder	4.4	5.8	7.7	-2.4	2.5	2.0	1.8	2.5	2.5	2.3	2.8	2.7	2.7	2.4	2.3
Worry (Nagel 2018)	0.2	0.4	1.4	0.2	-0.4	-0.3	-0.7	-0.8	-0.4	-0.3	-1.2	-0.4	0.2	-0.7	-0.6
Alzheimer’s Disease (in mother)	3.4	3.9	6.2	2.2	-2.2	-2.5	-1.4	-2.1	-2.2	-1.8	-1.0	-2.1	-1.2	-2.2	-2.3
Alzheimer’s Disease (in father)	1.5	1.6	4.2	1.4	-1.2	-0.6	-0.9	-1.7	-1.2	-1.5	-2.1	-1.0	-0.9	-1.3	-0.7
Alzheimer’s Disease (including proxy)	1.7	2.4	4.4	1.8	-1.5	-1.6	-0.7	-2.1	-1.5	-1.5	-1.6	-1.6	-1.0	-1.8	-1.3
Crohns Disease (2017)	0.1	0.1	0.7	-0.4	0.3	0.1	0.3	0.7	0.3	0.8	0.2	0.2	-0.1	-0.2	0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	-0.6	0.4	0.1	0.5	1.1	0.4	0.9	1.3	0.6	0.7	-0.2	0.4
Ulcerative Colitis (UC)	0.7	1.3	4.1	-1.0	1.0	0.5	0.7	1.4	1.0	1.0	2.0	1.1	1.5	0.4	0.9
Major Depression (MDD)	5.6	6.9	10.0	3.1	-3.2	-2.1	-3.0	-2.2	-3.2	-3.0	-1.9	-2.3	-2.3	-2.1	-2.5
Reaction Time	1.2	2.3	5.2	-1.6	1.2	0.5	1.2	1.8	1.2	1.9	2.3	1.2	1.7	1.7	1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.1	0.2	-0.0	-0.1	0.3	-0.1	-0.0	-0.2	-0.1	-0.7	-1.0	0.3	0.1
Breast Cancer	0.2	0.4	1.1	-0.6	0.5	0.3	0.7	0.8	0.5	0.8	1.1	0.5	0.6	0.3	0.4
Ovarian Cancer	1.5	1.9	2.9	-1.3	1.6	1.6	1.5	1.4	1.6	1.2	1.0	1.5	0.4	1.2	1.7
Prostate Cancer	0.5	0.7	1.8	0.9	-0.8	-1.3	0.8	-0.8	-0.8	-0.0	-0.4	-0.9	-0.3	-1.3	-0.9
Age at First Birth	0.6	0.8	2.0	0.9	-0.9	-0.8	-1.0	-1.4	-0.9	-0.4	-1.1	-0.7	0.6	-0.8	-1.1
Bipolar Disorder (2011)	4.0	3.8	5.8	2.0	-2.0	-2.1	-1.6	-1.4	-2.0	-2.3	-0.6	-2.4	-2.4	-2.0	-1.8
Body Mass Index (BMI) (2010)	0.9	1.2	3.0	-1.3	0.9	0.2	1.7	1.0	0.9	1.4	1.3	0.8	1.3	1.0	0.9
Coronary Artery Disease (CAD)	0.9	1.1	3.6	-0.9	1.2	-0.2	1.9	0.7	1.2	1.6	1.4	0.2	0.7	-0.2	0.5
Crohns Disease (2012)	1.0	1.6	3.1	-1.4	1.4	1.3	0.4	1.1	1.4	1.4	1.0	1.5	1.8	1.0	0.9
Mean Putamen Volume	0.2	0.3	0.9	-0.5	0.5	0.4	1.0	0.1	0.5	0.6	-0.1	0.4	0.5	0.5	0.6
Fasting Glucose	0.3	0.3	0.9	-0.5	0.7	0.7	-0.1	-0.1	0.7	-0.1	-0.2	0.8	1.0	0.5	0.6
HbA1C	0.3	0.3	0.8	0.1	-0.9	-0.9	0.3	0.0	-0.9	0.0	0.3	-0.3	0.4	-0.3	-0.6
HDL Cholesterol	0.4	0.7	2.8	-0.5	0.3	1.7	-1.2	0.8	0.3	-0.5	0.2	1.3	-0.0	0.8	0.9
LDL Cholesterol	0.1	0.2	1.2	0.1	0.2	0.6	-0.2	-0.5	0.2	-0.1	-1.1	0.1	0.1	0.2	0.4
Lupus	0.3	0.4	1.0	0.5	-0.8	-0.7	0.0	-0.8	-0.8	0.1	-1.0	-0.5	0.3	-0.5	-0.6
Neuroticism (2016)	0.8	1.2	3.5	-1.1	0.9	0.2	1.1	1.1	0.9	1.0	1.9	0.8	1.4	0.8	0.8
Primary Biliary Cirrhosis	0.8	1.2	2.2	1.0	-1.1	-1.5	-0.7	-1.1	-1.1	-0.7	-0.6	-1.4	-0.4	-1.3	-1.4
Rheumatoid Arthritis	0.0	0.1	0.3	-0.1	0.1	-0.2	0.5	0.0	0.1	0.4	0.2	-0.3	-0.2	-0.2	0.1
Schizophrenia (2014)	0.4	0.9	5.0	-0.5	0.4	-0.4	0.7	0.8	0.4	1.0	2.2	0.3	1.4	0.4	0.2
Triglycerides	0.9	1.4	3.5	1.3	-1.0	-0.9	-0.2	-1.4	-1.0	-0.6	-1.9	-1.4	-1.4	-1.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.6	-0.1	0.2	0.4	0.5	0.4	0.2	0.8	0.2	0.3	-0.2	0.1	0.5
Ulcerative Colitis	0.5	0.7	1.8	-0.6	0.8	0.9	0.1	0.9	0.8	0.4	1.3	1.0	0.9	0.3	0.9
Blood Eosinophil Count	2.2	16.7	40.3	3.7	-4.0	-2.9	-4.1	-5.0	-4.0	-3.3	-6.3	-3.7	-2.2	-4.0	-4.4
Blood Platelet Count	0.0	0.4	1.7	0.4	-0.3	0.7	-0.8	0.0	-0.3	-0.9	-0.7	0.2	-1.3	-0.2	0.3
Blood Red Count	0.2	1.6	2.2	-1.4	1.4	1.1	1.2	1.2	1.4	1.0	1.4	1.2	0.9	1.4	1.5
Blood White Count	0.0	0.3	1.1	-0.3	0.2	-0.6	1.0	0.4	0.2	0.4	1.0	-0.4	-0.3	-0.7	0.2
Heel T-Score	0.0	0.2	1.4	-0.4	0.1	-0.6	-0.3	0.4	0.1	-0.0	1.2	-0.2	0.3	0.4	-0.4
BMI	0.3	1.9	7.2	-0.8	0.8	-1.7	2.7	0.6	0.8	1.2	2.7	-0.3	1.3	-0.4	0.3
Height	0.2	3.8	7.6	2.2	-2.3	-1.2	-1.8	-1.3	-2.3	-1.8	-1.7	-1.9	-2.8	-1.7	-2.0
Waist Hip Ratio (WHR)	0.1	0.4	1.2	-0.6	0.9	0.5	1.1	0.4	0.9	0.3	0.3	0.3	0.0	0.6	1.0
Systolic Blood Pressure	0.1	0.3	0.8	0.9	-0.6	0.0	0.2	-0.4	-0.6	-0.8	-0.5	-0.1	-0.9	-0.9	0.2
Smoking Status	0.0	0.0	0.1	-0.4	0.2	-0.2	-0.2	0.0	0.2	0.1	-0.3	-0.1	0.2	0.2	-0.3
Allergy or Eczema	0.2	0.5	1.1	-0.4	0.6	1.1	1.0	0.6	0.6	0.6	-0.2	0.9	0.3	0.8	0.9
Cardiovascular Disease	0.2	0.7	3.2	0.7	-0.2	-0.5	1.8	-0.7	-0.2	-0.4	-0.8	-0.6	-1.0	-1.1	0.3
Hypothyroidism (self reported)	0.1	0.2	1.0	-0.3	0.1	0.2	-0.4	0.8	0.1	0.2	1.0	0.3	-0.1	0.5	0.1
Respiratory disease	0.2	0.5	1.4	-0.6	0.8	0.2	0.7	0.4	0.8	0.6	1.2	0.4	0.9	0.7	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	0.5	-0.2	-0.6	1.0	-0.4	-0.2	0.1	-0.1	-0.6	-0.3	-0.7	-0.2
Lung FEV1/FVC ratio	1.0	5.0	10.5	2.4	-2.3	-2.6	-0.1	-2.4	-2.3	-1.3	-1.8	-2.7	-2.0	-3.2	-2.1
Lung FVC	0.2	1.1	3.3	-0.7	0.8	1.8	0.5	1.6	0.8	0.4	-0.1	1.0	-0.7	1.2	1.4
Neuroticism	0.4	1.0	2.2	0.7	-1.1	-1.0	-1.0	-1.3	-1.1	-0.4	-1.5	-0.7	0.8	-1.0	-1.2
Chronotype (morning person)	0.3	0.8	2.4	-0.7	0.6	1.3	-0.7	0.5	0.6	0.0	0.4	1.5	1.2	1.0	0.9
Hair Pigment	0.0	0.7	3.2	0.8	-0.9	-0.5	-1.8	-0.9	-0.9	-0.9	-0.3	-0.4	0.2	0.1	-1.0
Tanning	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	0.3	-0.1	0.1	0.1	0.0	-0.1	0.2	0.0
Hand grip strength (left)	2.4	6.2	10.5	-2.9	2.8	2.4	2.6	3.2	2.8	2.7	1.9	2.2	0.7	2.1	2.4
Number of treatments/medications taken	0.4	0.7	2.2	0.7	-0.2	-0.8	1.5	-0.2	-0.2	-0.5	-0.3	-1.1	-1.4	-0.9	0.1
Average weekly spirits intake	0.3	0.4	1.0	0.5	-0.6	-1.0	-0.2	-0.7	-0.6	-0.5	-0.5	-0.7	-0.0	-0.7	-0.8
Sensitivity / hurt feelings	0.5	0.9	3.3	-1.4	0.9	0.6	-0.3	0.3	0.9	0.5	-0.0	1.0	1.8	1.1	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.5	-0.8	0.4	-0.1	0.8	0.9	0.4	1.1	1.2	0.2	0.7	0.2	0.3
Hearing difficulty/problems: Yes	0.3	0.5	0.9	0.8	-0.7	-0.8	-0.7	-0.7	-0.7	-0.6	-0.2	-1.0	-0.7	-0.0	-0.9
Relative age of first facial hair	0.7	1.4	2.0	-1.2	1.4	1.1	1.2	1.3	1.4	0.8	1.2	1.1	0.4	1.3	1.4
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.6	1.5	-1.5	-2.4	0.4	-1.0	-1.5	-0.7	0.0	-1.9	-1.2	-1.9	-1.6
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.4	1.0	-0.9	-1.4	-0.7	-1.8	-0.9	-0.7	-1.2	-1.2	0.1	-1.1	-1.2
Ever had hysterectomy (womb removed)	1.0	1.1	1.6	-1.2	1.3	1.0	1.0	1.1	1.3	0.7	1.2	0.8	0.2	1.1	1.2
Systolic blood pressure, automated reading	1.3	3.8	6.2	2.5	-2.2	-1.7	-1.0	-1.8	-2.2	-2.3	-1.5	-1.9	-2.1	-2.2	-1.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.6	-1.3	1.6	1.2	0.7	1.3	1.6	1.0	0.7	1.2	0.9	1.6	1.2
Angina	0.5	0.7	2.3	0.9	-0.9	-0.7	0.1	-0.9	-0.9	-0.3	-1.5	-0.5	-0.3	-1.1	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.5	0.6	0.4	-0.1	0.2	0.6	0.3	0.1	0.6	0.6	0.7	0.1
Vitamin and mineral supplements	4.3	5.8	10.7	2.9	-2.7	-1.1	-3.3	-2.4	-2.7	-2.9	-2.2	-1.9	-2.1	-2.2	-1.9
Supplements: Zinc	2.5	2.8	6.2	-1.9	1.3	-0.7	2.2	1.4	1.3	2.5	2.5	0.7	2.3	0.7	0.1
Medication: Co-codamol	0.2	0.2	0.5	0.1	0.1	0.6	0.7	0.4	0.1	-0.3	0.2	0.1	-0.7	-0.2	0.7
Medication: Metformin	0.2	0.2	0.9	0.3	0.0	-0.6	1.0	0.0	0.0	-0.1	0.4	-0.7	-0.7	-0.5	-0.0
Diabetes (father)	0.5	0.6	1.4	0.5	-0.7	-0.9	-0.7	-0.9	-0.7	-0.5	-1.2	-1.1	-0.5	-0.7	-0.8
Diabetes (mother)	0.6	0.7	1.7	0.8	-0.7	-0.9	0.0	-1.3	-0.7	-1.0	-0.6	-1.2	-0.6	-1.1	-0.6
Severe depression (siblings)	0.9	1.0	2.9	0.9	-1.0	-0.1	-1.2	-0.9	-1.0	-1.2	-0.3	-0.9	-1.7	-1.1	-0.3
Pack years adult smoking proportion	0.2	0.2	0.7	-0.8	0.7	0.3	0.4	-0.2	0.7	0.4	-0.8	0.1	0.1	0.3	0.2
Impedance of leg (right)	0.6	3.1	6.8	-1.9	1.9	2.6	0.6	1.7	1.9	1.4	0.8	2.5	1.1	1.7	2.0
Leg fat-free mass (left)	0.3	1.6	5.1	1.1	-1.2	-2.3	0.1	-0.8	-1.2	-0.4	-0.3	-1.9	-0.8	-1.4	-1.6
Trunk fat percentage	0.2	0.7	4.6	-0.3	0.4	-1.3	2.1	-0.3	0.4	0.7	0.7	-0.6	0.7	-0.1	0.1
Hand grip strength (right)	0.8	2.3	4.3	-1.8	1.6	1.0	1.8	2.1	1.6	2.0	1.3	1.3	0.7	1.1	1.1
Townsend deprivation index at recruitment	0.3	0.5	1.3	-0.9	0.9	0.7	0.1	0.2	0.9	0.4	-0.2	0.9	1.1	0.4	0.6
Current tobacco smoking	1.6	2.6	4.9	-2.2	1.8	0.9	0.8	1.6	1.8	1.8	1.4	1.6	2.0	1.7	0.9
Average weekly fortified wine intake	0.2	0.3	1.6	0.1	-0.2	-0.3	-0.2	0.2	-0.2	0.4	0.9	0.3	1.3	0.1	-0.2
Maternal smoking around birth	0.5	0.7	1.3	-0.9	0.8	0.0	0.8	1.1	0.8	0.8	1.1	0.7	1.0	0.9	0.5
Fed-up feelings	0.3	0.5	3.2	-0.9	0.5	0.1	0.0	0.2	0.5	0.9	0.3	0.5	1.8	0.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.9	-1.2	0.8	-0.6	1.7	1.1	0.8	1.7	1.7	0.1	1.3	0.9	0.4
Relative age voice broke	6.0	9.2	12.0	-3.5	3.3	2.1	2.6	3.1	3.3	3.3	3.0	3.1	3.2	3.1	2.4
Taking other prescription medications	0.1	0.1	0.8	-0.1	0.1	-0.5	0.9	0.0	0.1	0.3	0.5	-0.5	0.1	-0.0	0.1
Age when periods started (menarche)	0.2	0.4	2.0	-0.0	-0.1	0.4	0.1	1.2	-0.1	-0.1	1.1	-0.0	-1.4	0.6	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.8	0.6	-0.2	0.4	0.4	0.6	0.9	0.3	0.0	0.7	0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	1.0	-1.1	-1.1	-0.7	-0.5	-1.1	-1.0	-0.4	-1.2	-1.4	-0.9	-1.1
Tinnitus: Yes, but not now, but have in the past	3.8	4.0	5.3	1.9	-2.0	-2.3	-1.6	-2.0	-2.0	-2.2	-1.4	-2.1	-1.8	-2.3	-2.2
Qualifications: CSEs or equivalent	0.3	0.4	1.8	-0.1	0.0	0.5	-1.1	-0.7	0.0	-0.3	-1.4	0.3	0.6	0.1	-0.3
Serious illness, injury or assault to yourself	2.2	2.7	5.2	1.8	-1.9	-2.1	0.1	-1.4	-1.9	-1.1	-1.0	-1.8	-1.5	-2.3	-1.7
High blood pressure	1.0	2.8	7.1	2.1	-1.6	-1.3	0.4	-1.4	-1.6	-1.7	-1.7	-1.9	-2.7	-2.0	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.1	0.4	-0.4	0.6	-0.6	-0.2	-0.4	-0.3	-1.0	0.1	-0.5	0.3	0.0
Multivitamins +/- minerals	2.9	3.6	6.5	-2.3	2.2	0.9	2.5	1.7	2.2	2.3	1.5	1.4	1.7	1.9	1.5
Stomach or abdominal pain in last month	0.6	0.8	3.8	-1.1	0.8	-0.4	2.0	0.3	0.8	1.3	0.4	0.1	1.0	0.2	0.3
Supplements: Glucosamine	0.3	0.4	1.4	-0.3	0.4	1.1	0.0	1.2	0.4	-0.2	0.5	0.6	-0.9	0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.1	0.1	-0.3	-0.2	0.2	0.1	-0.2	-0.0	-0.4	-0.7	0.4	-0.4
Medication: Atenolol	0.2	0.2	0.6	0.2	-0.0	-0.4	0.8	0.8	-0.0	0.7	0.7	-0.0	-0.5	-0.3	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.3	0.1	-0.2	-0.2	0.2	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.4
Sitting height	0.6	4.3	5.9	2.3	-2.4	-1.4	-2.1	-1.8	-2.4	-1.7	-2.4	-2.1	-2.0	-1.8	-2.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.3	-0.6	0.4	-0.6	1.1	-0.6	0.4	1.0	-1.0	-0.2	1.0	-0.1	-0.3
High blood pressure (mother)	0.5	0.7	2.5	1.1	-0.9	0.0	-1.6	-0.5	-0.9	-1.5	0.3	-0.2	-0.9	-0.3	-0.3
Body mass index (BMI)	0.3	1.2	6.0	0.4	-0.3	-2.5	1.6	-0.8	-0.3	0.1	0.7	-1.5	0.3	-1.3	-0.9
Impedance of leg (left)	0.6	3.1	6.0	-2.0	1.9	2.5	0.9	1.4	1.9	1.5	0.5	2.2	1.2	1.9	2.0
Leg predicted mass (left)	0.3	1.7	5.3	1.1	-1.3	-2.3	0.1	-0.9	-1.3	-0.4	-0.3	-2.0	-0.8	-1.5	-1.6
Trunk fat mass	0.2	0.8	3.6	0.1	-0.0	-1.9	1.9	-0.5	-0.0	0.4	0.5	-1.1	0.2	-0.6	-0.4
Waist circumference	0.3	1.2	5.3	0.2	-0.1	-2.3	2.1	-0.7	-0.1	0.5	0.7	-1.5	0.3	-1.0	-0.7
Number of incorrect matches in round	0.9	1.6	4.5	1.4	-1.4	-0.2	-2.1	-1.1	-1.4	-1.6	-1.4	-0.5	-1.1	-0.6	-1.1
Past tobacco smoking	0.2	0.4	1.4	-0.3	0.3	1.1	0.6	0.7	0.3	0.3	0.6	0.8	-0.1	0.3	1.2
Alcohol usually taken with meals	0.9	1.5	3.9	-1.0	1.1	2.0	0.3	1.3	1.1	1.0	0.4	1.8	1.1	1.2	1.4
Nervous feelings	0.0	0.1	0.2	0.1	-0.3	-0.2	-0.4	-0.1	-0.3	0.2	-0.3	-0.3	0.1	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.7	1.1	-1.4	-1.7	-1.0	-1.0	-1.4	-0.8	-0.1	-1.5	-0.4	-0.7	-1.4
Hearing difficulty/problems with background noise	0.2	0.3	1.1	-0.4	0.5	0.7	0.5	0.0	0.5	0.6	-0.1	0.3	0.5	1.0	0.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	-0.6	0.4	1.0	-1.2	-0.1	0.4	-0.3	-0.6	0.6	0.6	1.2	0.5
Had menopause	2.0	2.5	4.7	1.7	-1.9	-1.7	-1.4	-2.2	-1.9	-1.3	-1.2	-1.5	-0.5	-1.6	-1.6
Had other major operations	2.2	2.6	4.4	-1.9	1.8	0.8	2.1	1.0	1.8	2.0	1.2	1.1	1.9	1.8	1.4
Forced vital capacity (FVC)	0.2	0.6	2.4	-0.5	0.3	1.5	-0.2	1.2	0.3	0.2	-0.3	0.7	-0.9	0.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.1	1.0	-1.0	-0.9	-0.8	-0.7	-1.0	-1.0	-0.7	-0.9	-0.9	-0.9	-1.1
Ever unenthusiastic/disinterested for a whole week	3.6	4.4	7.0	2.1	-2.2	-2.6	-0.8	-2.6	-2.2	-1.3	-2.2	-2.5	-1.0	-2.4	-2.4
Qualifications: None of the above	0.2	0.4	1.7	0.2	-0.2	-1.3	0.9	-0.8	-0.2	-0.3	-0.0	-0.8	0.2	-0.9	-0.4
Financial difficulties in last 2 years	0.4	0.5	1.4	0.5	-0.8	-1.2	-0.2	-0.8	-0.8	-0.5	-0.2	-0.9	0.0	-1.0	-0.8
Mouth/teeth dental problems	0.5	0.7	3.0	-0.1	0.4	1.7	-0.4	1.3	0.4	-0.2	0.3	1.2	-0.2	0.7	1.2
Heart attack	2.6	3.3	4.3	-2.0	2.0	1.8	2.0	2.0	2.0	2.1	1.1	1.8	1.1	1.8	1.9
Allergy	0.2	0.4	1.6	0.3	-0.5	-1.1	0.0	-0.3	-0.5	-0.2	0.3	-0.8	-0.2	-1.3	-0.7
Pain all over the body in last month	1.6	1.7	2.9	-1.5	1.4	0.9	0.5	1.5	1.4	1.4	1.3	1.4	1.7	1.5	0.8
Diabetes (self-reported)	0.7	1.1	2.5	1.3	-1.0	-1.1	-0.5	-1.0	-1.0	-1.1	-0.5	-1.2	-0.9	-1.6	-0.9
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.4	-1.0	0.9	1.6	0.2	1.3	0.9	0.8	0.8	1.1	-0.1	1.0	1.1
Medication: Ramipril	1.5	2.0	3.7	1.6	-1.6	-1.6	-0.4	-0.4	-1.6	-1.3	-0.1	-1.7	-1.9	-1.7	-1.2
Medication: Simvastatin	1.2	1.8	3.3	1.3	-1.2	-1.5	0.4	-1.5	-1.2	-0.9	-1.6	-1.6	-1.2	-1.8	-1.1
Fluid intelligence score	0.3	0.6	3.1	0.9	-0.8	-0.1	-0.4	0.1	-0.8	-0.9	-0.0	-0.6	-1.8	-0.1	-0.2
Illnesses of siblings	1.6	2.2	3.9	-1.7	1.5	1.8	0.5	2.0	1.5	1.4	1.3	1.5	0.9	1.8	1.3
Neuroticism score	0.2	0.5	2.9	-0.5	-0.0	-0.2	-0.7	-0.8	-0.0	0.4	-1.2	0.1	1.7	0.2	-0.4
Weight	0.3	1.3	5.8	0.7	-0.7	-2.4	1.1	-0.8	-0.7	0.1	0.2	-1.7	-0.2	-1.4	-1.2
Impedance of arm (right)	0.3	1.3	5.1	-0.7	0.9	2.3	-0.0	0.9	0.9	0.3	-0.0	1.5	0.2	1.6	1.6
Arm fat percentage (right)	0.3	1.2	6.2	-0.2	0.4	-1.8	2.5	-0.2	0.4	0.8	1.6	-0.9	0.8	-0.5	0.0
Trunk fat-free mass	0.3	1.7	5.4	1.0	-1.3	-2.3	-0.2	-0.7	-1.3	-0.3	-0.2	-1.9	-0.9	-1.6	-1.8
Hip circumference	0.2	1.1	5.3	-0.3	0.3	-1.8	2.3	-0.1	0.3	1.1	1.1	-0.9	0.5	-0.6	-0.4
Time employed in main current job	0.3	0.4	1.4	0.1	-0.1	1.2	-0.7	-0.4	-0.1	-0.0	-1.0	0.9	0.6	-0.1	0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.6	-0.4	0.8	0.6	1.3	0.2	0.8	0.4	-0.1	0.5	0.3	0.1	1.0
Father’s age at death	0.2	0.3	0.7	0.6	-0.6	0.7	-0.8	0.5	-0.6	-0.4	-0.0	0.4	-0.7	0.4	0.3
Worrier / anxious feelings	0.1	0.2	1.1	-0.5	0.2	0.1	-0.1	0.0	0.2	0.4	-0.7	0.2	1.0	0.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.1	0.1	-0.3	-1.4	0.4	-1.0	-0.3	0.4	-0.2	-1.1	0.5	-0.4	-0.9
Falls in the last year	1.1	1.5	2.9	1.3	-1.1	-1.7	0.1	-1.5	-1.1	-0.5	-1.3	-1.5	-0.5	-1.6	-1.6
Hair/balding pattern: Pattern 3	1.2	1.8	2.4	-1.4	1.6	1.2	1.5	1.4	1.6	1.3	0.9	1.4	1.1	0.8	1.5
Number of live births	0.4	0.6	1.5	-0.9	0.9	0.4	1.0	0.6	0.9	0.9	-0.1	0.4	0.6	1.2	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.8	0.1	-0.3	1.0	-0.4	0.8	-0.3	-0.2	-0.4	0.2	-1.3	0.2	0.3
Pulse rate	0.6	1.1	2.7	1.1	-0.9	-1.5	0.3	-0.8	-0.9	-0.9	-0.2	-1.3	-1.2	-1.6	-0.9
Happiness	7.3	8.8	12.3	3.2	-3.5	-2.8	-2.8	-3.2	-3.5	-2.9	-2.5	-2.8	-1.9	-3.0	-3.2
Noisy workplace	3.5	4.3	7.1	2.2	-2.1	-2.2	-1.5	-1.9	-2.1	-2.1	-1.6	-2.2	-1.9	-2.7	-2.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	1.2	-1.0	-0.4	-1.2	-0.3	-1.0	-0.9	-0.2	-0.8	-0.7	0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.9	-0.8	0.9	0.2	2.0	0.6	0.9	0.9	0.8	0.6	0.6	0.8	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.1	0.9	-1.2	-1.8	-0.6	-1.8	-1.2	-0.8	-0.7	-1.4	-0.1	-1.1	-1.4
Asthma	0.6	1.2	2.4	-1.1	1.4	1.3	0.7	0.8	1.4	1.0	0.7	0.8	0.6	1.6	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.5	-1.9	1.8	1.2	1.6	1.4	1.8	1.5	1.0	1.2	1.3	1.5	1.7
Medication: Cholesterol lowering	1.3	2.1	3.5	1.8	-1.5	-1.9	0.5	-0.8	-1.5	-1.0	-0.6	-1.8	-1.8	-1.9	-1.2
Depression (self-reported)	0.2	0.2	1.1	-0.1	-0.0	-1.0	0.1	-0.2	-0.0	0.3	-0.0	-0.4	0.7	0.0	-0.9
Medication: Lansoprazole	4.8	5.4	12.3	-2.7	2.3	0.7	3.5	2.5	2.3	2.9	2.9	1.1	1.4	2.0	2.0
Prospective memory result	4.9	6.1	9.5	-2.5	2.5	3.1	2.1	2.8	2.5	2.2	1.7	2.9	1.4	2.4	2.9
Lung cancer (father)	0.8	1.0	1.5	-1.0	1.2	1.2	1.2	0.2	1.2	0.8	-0.2	1.0	0.5	1.2	1.2
Illnesses of mother	3.4	4.2	7.5	-2.4	2.2	1.5	2.5	1.9	2.2	2.7	0.4	2.0	2.1	2.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.7	0.4	-0.7	0.8	-0.8	0.8	-0.7	-0.5	-0.6	0.0	-1.6	-0.2	0.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.7	0.6	0.4	0.2	0.7	0.6	0.5	0.8	0.5	0.4	0.6	0.4
Impedance of arm (left)	0.2	1.1	4.7	-0.4	0.7	2.2	-0.1	0.7	0.7	0.1	-0.4	1.2	-0.3	1.5	1.5
Arm fat mass (right)	0.3	1.2	5.3	0.2	-0.1	-2.3	2.0	-0.5	-0.1	0.5	1.1	-1.4	0.4	-1.0	-0.6
Trunk predicted mass	0.3	1.9	5.7	1.1	-1.4	-2.4	-0.2	-0.8	-1.4	-0.3	-0.3	-2.0	-0.9	-1.6	-1.9
Standing height	0.1	0.6	1.2	0.8	-1.0	-0.3	-1.0	-0.3	-1.0	-0.3	-1.1	-0.7	-1.1	-0.4	-0.9
Length of working week for main job	0.4	0.4	2.3	0.5	-0.9	-0.3	-1.5	-0.3	-0.9	-0.2	0.2	-0.2	0.4	0.2	-0.8
Exposure to tobacco smoke at home	0.8	0.8	3.5	-0.9	0.9	0.5	0.3	1.3	0.9	0.2	1.9	0.9	0.6	0.7	0.6
Breastfed as a baby	0.3	0.4	3.3	0.3	0.1	0.4	0.0	-1.1	0.1	-0.2	-1.8	0.1	-0.0	-0.1	0.3
Tense / ‘highly strung’	0.5	0.8	1.4	-1.2	1.0	1.0	0.3	0.9	1.0	1.1	0.3	1.0	0.8	1.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.5	-0.5	-1.0	-0.2	0.0	-0.5	-0.2	-0.3	-0.8	-0.5	-0.4	-0.8
Hair/balding pattern: Pattern 4	0.1	0.4	1.3	0.5	-0.4	-0.8	-0.5	-0.0	-0.4	-0.3	1.1	-0.7	-0.7	-0.4	-0.7
Birth weight of first child	0.2	0.3	1.1	0.2	-0.3	0.6	-1.1	0.8	-0.3	-0.3	0.9	0.4	-0.2	0.2	0.3
Peak expiratory flow (PEF)	0.1	0.3	1.5	0.3	-0.4	0.6	-0.5	0.2	-0.4	-0.1	-0.9	-0.2	-1.2	0.4	-0.1
Pulse wave reflection index	0.3	0.4	1.0	-0.4	0.3	1.0	-0.9	0.9	0.3	0.0	0.5	0.7	-0.0	0.9	0.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.6	0.9	-1.3	-1.2	-1.6	-0.9	-1.3	-1.1	-0.3	-1.0	-0.7	-1.1	-1.3
Loud music exposure frequency	5.7	6.2	13.8	2.7	-2.9	-2.3	-3.7	-2.0	-2.9	-2.9	-0.5	-2.3	-1.6	-2.0	-2.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	-0.9	1.0	0.7	1.0	0.8	1.0	1.2	0.5	0.7	1.0	1.0	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	5.1	-0.7	0.7	-0.7	2.3	0.2	0.7	1.1	0.7	-0.4	-0.2	-0.0	0.3
Blood clot in the leg (DVT)	0.8	1.1	3.2	1.1	-0.8	-0.9	-1.0	-1.6	-0.8	-0.8	-1.8	-0.6	0.1	-0.6	-1.3
Medication: Paracetamol	0.3	0.5	1.6	0.4	-0.4	-0.5	-0.0	-0.7	-0.4	-0.8	-0.8	-0.8	-0.8	-1.3	-0.3
Headache pain in last month	1.3	2.2	7.2	-1.7	1.8	1.0	2.7	1.0	1.8	1.5	0.8	0.8	0.8	0.7	1.9
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.2	-1.8	1.4	1.2	-0.7	0.5	1.4	0.8	0.7	1.4	2.0	1.4	0.7
Glaucoma (self-reported)	0.6	0.7	1.1	-0.7	0.8	0.9	0.7	1.0	0.8	0.8	0.8	1.1	0.8	1.0	0.9
Gout (self-reported)	0.7	1.0	1.9	1.4	-1.0	-0.2	-1.2	-0.7	-1.0	-1.2	-1.1	-0.6	-1.3	-0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.1	-0.2	-0.0	-0.7	0.6	-0.2	-0.3	0.8	-0.1	-0.5	0.4	-0.2
Medication: Amlodipine	0.2	0.3	0.8	0.1	0.4	0.6	0.5	0.5	0.4	-0.2	-0.2	0.3	-0.7	0.8	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	-0.9	0.9	0.8	0.5	1.0	0.9	0.7	0.6	0.6	0.2	0.9	0.9
Birth weight	0.8	1.7	5.8	1.3	-1.3	-0.5	-0.3	-0.9	-1.3	-0.8	-1.9	-1.4	-2.4	-1.3	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.2	-0.3	0.5	0.5	0.8	1.1	0.5	0.6	0.7	0.5	-0.3	0.5	0.5
High blood pressure (siblings)	0.0	0.1	0.1	-0.1	0.1	-0.4	0.3	-0.2	0.1	0.1	0.4	-0.0	0.3	0.1	0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	2.0	-0.1	-0.1	1.3	-0.4	1.1	-0.1	-0.2	-0.4	0.5	-1.4	0.2	0.5
Body fat percentage	0.3	1.1	6.3	-0.5	0.7	-1.4	2.5	-0.2	0.7	0.9	1.1	-0.6	0.9	-0.2	0.2
Leg fat percentage (right)	0.3	1.1	5.9	-0.5	0.6	-1.7	2.4	-0.1	0.6	0.9	1.3	-0.7	0.8	-0.8	-0.0
Arm fat-free mass (right)	0.3	1.4	5.5	0.7	-1.0	-2.4	0.4	-0.8	-1.0	-0.1	-0.2	-1.8	-0.6	-1.4	-1.6
Exposure to tobacco smoke outside home	0.4	0.5	1.7	-0.7	0.6	0.1	0.7	0.3	0.6	1.2	0.9	0.8	1.3	0.0	0.2
Comparative body size at age 10	0.7	1.9	5.0	-1.1	1.2	0.4	1.8	2.1	1.2	1.6	2.2	1.1	0.5	1.1	1.0
Number of full brothers	0.3	0.3	0.8	0.3	-0.6	-0.8	-0.5	-0.8	-0.6	-0.3	-0.3	-0.9	-0.3	0.2	-0.6
Worry too long after embarrassment	0.9	1.6	3.3	0.9	-1.2	-1.3	-1.4	-1.8	-1.2	-0.8	-1.5	-1.2	0.3	-1.0	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	0.9	-0.8	-0.9	-0.3	-0.5	-0.8	-0.4	-0.1	-0.8	-0.6	-0.7	-0.8
Wheeze or whistling in the chest in last year	0.4	0.8	2.2	-1.1	1.0	0.3	0.6	0.2	1.0	1.0	0.5	0.7	1.5	1.1	0.4
Number of children fathered	0.4	0.5	1.7	-0.5	0.9	0.6	1.3	-0.5	0.9	0.4	-0.6	0.5	0.6	0.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.9	0.3	-0.5	0.8	-2.0	-0.3	-0.5	-0.8	-0.8	0.4	0.0	0.0	-0.0
Age at first live birth	0.5	0.8	3.3	1.3	-1.0	-0.1	-0.8	-0.1	-1.0	-1.2	-0.0	-0.8	-1.8	-0.4	-0.3
Pulse wave peak to peak time	0.4	0.5	1.2	0.8	-0.7	-0.4	-0.3	-0.9	-0.7	-0.7	-1.1	-0.6	-0.5	-0.7	-0.5
Health satisfaction	0.5	0.7	2.4	0.5	-0.7	-1.6	0.4	-1.0	-0.7	-0.1	-0.6	-1.1	0.4	-1.0	-1.0
Shortness of breath walking on level ground	0.7	0.8	2.9	-1.0	0.8	-0.2	1.7	0.5	0.8	1.6	0.8	0.1	1.0	0.2	0.5
Qualifications: College or University degree	0.8	2.4	7.0	2.0	-1.9	-0.2	-2.6	-0.8	-1.9	-1.7	-1.3	-1.0	-1.8	-0.3	-1.2
Eye problems/disorders: None of the above	0.3	0.3	1.3	-0.7	0.4	0.2	0.6	0.3	0.4	0.9	0.3	0.6	1.2	-0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.1	-0.0	-0.2	-0.0	-1.0	-0.5	-0.2	-0.2	-0.9	-0.2	-0.0	0.2	-0.6
Emphysema/chronic bronchitis	0.2	0.2	1.4	-0.2	0.3	-0.3	-0.2	-0.7	0.3	0.1	-0.2	0.1	1.2	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.8	2.2	-0.8	0.5	0.5	-0.4	1.0	0.5	0.8	1.5	1.2	1.3	1.1	0.0
Neck or shoulder pain in last month	8.6	12.2	19.4	-3.9	3.9	2.5	4.1	2.7	3.9	4.4	1.7	3.2	3.7	3.6	3.4
Medication: Blood pressure	0.8	1.5	2.9	1.7	-1.3	-1.2	-0.1	-0.6	-1.3	-1.3	-0.6	-1.2	-1.7	-1.5	-0.9
Angina (self-reported)	0.5	0.6	2.0	0.9	-0.9	-0.7	0.0	-0.7	-0.9	-0.3	-1.4	-0.5	-0.3	-1.0	-0.8
Migraine (self-reported)	0.4	0.5	2.7	0.5	-0.5	-0.2	-0.2	-1.3	-0.5	-0.2	-1.6	-0.4	0.4	-0.4	-0.5
Medication: Ibuprofen	0.7	0.8	1.9	-1.4	1.2	0.6	0.6	0.5	1.2	0.9	0.4	0.6	1.2	1.0	0.8
Medication: Allopurinol	0.2	0.3	1.2	0.9	-0.5	-0.2	-0.2	-0.4	-0.5	-0.5	-0.5	-0.6	-1.1	-0.3	-0.2
Medication: Omeprazole	1.6	1.9	5.4	-1.4	1.8	1.2	2.3	0.6	1.8	1.2	-1.0	0.7	0.6	1.2	1.5
Medication: Seretide 50 evohaler	0.1	0.1	0.7	0.2	-0.2	0.1	-0.1	-0.4	-0.2	-0.3	-0.9	-0.0	-0.2	0.1	0.2
Mean time to correctly identify matches	0.3	0.6	2.2	0.3	-0.7	-1.4	-0.2	0.3	-0.7	0.3	1.5	-0.7	0.3	-0.1	-0.9
Heart disease (mother)	4.5	5.5	7.8	2.5	-2.5	-2.3	-1.8	-2.7	-2.5	-2.8	-1.7	-2.5	-1.7	-2.8	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.3	1.7	-1.7	-0.8	-1.8	-1.4	-1.7	-1.6	-2.1	-1.2	-1.6	-1.0	-1.7
Whole body fat mass	0.3	1.1	5.2	-0.1	0.1	-2.1	2.3	-0.4	0.1	0.7	1.0	-1.2	0.5	-0.8	-0.4
Leg fat mass (right)	0.3	1.3	5.5	-0.1	0.0	-2.3	2.3	-0.4	0.0	0.7	1.0	-1.3	0.3	-1.1	-0.6
Arm predicted mass (right)	0.4	2.0	6.4	1.1	-1.3	-2.5	-0.1	-1.1	-1.3	-0.5	-0.5	-2.1	-0.9	-1.6	-1.9
Pulse rate, automated reading	0.8	2.7	5.9	1.6	-1.5	-2.2	0.2	-0.9	-1.5	-1.5	0.2	-2.1	-2.3	-2.4	-1.3
Alcohol intake frequency.	0.4	1.0	3.2	1.1	-1.0	-1.1	0.1	-1.5	-1.0	-0.9	-0.8	-1.0	-0.1	-1.8	-0.4
Comparative height size at age 10	0.9	5.1	8.4	2.5	-2.4	-2.1	-1.2	-2.2	-2.4	-2.0	-2.0	-2.4	-2.4	-2.9	-2.2
Number of full sisters	0.5	0.6	1.3	0.4	-0.4	-0.8	-0.3	-1.1	-0.4	-0.6	-1.1	-1.1	-0.7	-0.9	-0.7
Suffer from ‘nerves’	0.2	0.2	0.8	-0.2	-0.1	-0.4	-0.4	-0.8	-0.1	0.1	-0.9	-0.2	0.8	-0.1	-0.5
Overall health rating	0.3	0.6	2.1	-0.3	0.4	-0.9	1.5	-0.5	0.4	0.9	-0.1	-0.1	1.4	-0.7	-0.0
Chest pain or discomfort	2.4	3.5	6.0	-2.1	2.1	1.1	2.5	1.4	2.1	2.4	1.0	1.4	1.9	1.9	1.8
Had major operations	1.5	1.8	4.5	1.5	-1.3	-1.8	0.8	-1.5	-1.3	-0.7	-0.5	-1.7	-0.9	-2.1	-1.0
Age at last live birth	0.2	0.3	1.4	-0.0	-0.0	0.2	0.1	0.9	-0.0	0.1	1.2	-0.0	-0.4	0.9	0.2
Family relationship satisfaction	1.6	2.0	4.3	1.3	-1.5	-2.1	-1.3	-1.7	-1.5	-1.0	-0.4	-1.4	0.5	-1.2	-2.0
Leg pain on walking	0.2	0.2	0.6	0.1	-0.1	-0.7	0.7	0.1	-0.1	0.5	0.8	-0.4	0.4	-0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.1	0.1	-0.2	-0.6	-0.4	-0.1	-0.2	0.1	0.8	-0.1	0.3	-1.1	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	-0.9	0.8	0.1	1.1	1.2	0.8	0.9	1.5	0.2	-0.2	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	-1.1	0.9	1.5	-0.5	1.3	0.9	0.9	0.8	1.2	0.8	1.4	0.8
Medication: Aspirin	3.0	3.9	6.1	2.3	-2.0	-1.5	-1.2	-1.9	-2.0	-1.8	-2.4	-2.2	-2.5	-1.8	-1.8
Supplements: Vitamin C	1.3	1.6	3.7	-1.4	1.2	-0.2	1.6	1.2	1.2	1.6	1.9	0.5	1.5	1.0	0.5
Knee pain experienced in last month	0.4	0.6	3.1	-0.6	0.5	-0.6	1.8	-0.1	0.5	1.1	0.6	-0.2	0.8	0.1	0.2
Hypertension (Self-reported)	1.1	3.1	6.7	2.2	-1.7	-1.3	0.1	-1.6	-1.7	-1.9	-1.9	-1.9	-2.6	-2.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.6	-1.7	1.8	0.8	2.1	1.0	1.8	1.8	0.5	0.9	1.5	1.3	1.4
Illnesses of father: Heart disease	0.7	1.0	1.9	1.4	-1.1	-1.4	0.1	-0.6	-1.1	-0.7	-0.1	-1.2	-0.9	-1.3	-1.1
Illnesses of siblings: Diabetes	1.2	1.5	2.7	-1.2	1.2	0.9	1.2	1.2	1.2	0.8	1.7	1.0	1.0	1.4	1.5
Smoking status: Previous	0.7	1.0	1.4	1.1	-0.9	-1.0	-0.9	-0.8	-0.9	-1.1	-1.0	-1.1	-1.1	-0.8	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	6.3	1.9	-2.1	-1.6	-1.9	-1.5	-2.1	-1.8	-2.5	-1.9	-1.9	-1.6	-2.2
Whole body fat-free mass	0.3	1.8	5.6	1.1	-1.3	-2.4	-0.0	-0.9	-1.3	-0.3	-0.4	-2.0	-0.9	-1.6	-1.8
Leg fat-free mass (right)	0.3	1.5	4.7	1.1	-1.2	-2.2	0.2	-0.9	-1.2	-0.3	-0.5	-2.0	-0.8	-1.3	-1.5
Arm fat percentage (left)	0.3	1.1	4.8	0.1	0.1	-2.0	2.2	-0.4	0.1	0.4	1.2	-1.2	0.3	-0.6	-0.2
Average weekly red wine intake	1.6	2.4	3.4	-1.6	1.6	1.7	0.7	1.8	1.6	1.6	1.5	1.6	1.3	1.7	1.5
Handedness (chirality/laterality): Left-handed	4.5	5.4	8.8	-2.7	2.5	1.9	2.1	1.7	2.5	2.5	1.9	2.3	3.0	2.1	2.3
Mood swings	0.4	0.7	2.8	0.3	-0.7	-0.8	-0.5	-1.2	-0.7	-0.2	-1.7	-0.7	0.5	-0.9	-0.8
Loneliness, isolation	0.5	0.7	1.6	0.6	-0.8	-1.3	-0.6	-1.1	-0.8	-0.6	-0.0	-1.1	-0.1	-1.2	-0.9
Long-standing illness, disability or infirmity	0.4	0.6	2.3	0.5	-0.3	-1.5	1.1	0.0	-0.3	0.5	1.1	-0.8	0.1	-0.8	-0.6
Ever had bowel cancer screening	2.0	2.4	5.1	-1.2	1.6	1.2	2.3	2.0	1.6	1.1	1.9	1.1	0.2	1.4	1.8
Diabetes diagnosed by doctor	0.5	0.8	1.5	1.2	-0.9	-1.0	-0.3	-0.9	-0.9	-1.0	-0.4	-1.0	-0.6	-1.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.8	-1.1	1.0	0.5	0.6	0.5	1.0	1.1	0.2	0.8	1.4	1.2	0.7
Friendships satisfaction	1.8	2.2	4.4	1.6	-1.4	-2.1	-0.4	-1.9	-1.4	-1.2	-1.2	-1.7	-0.5	-1.5	-1.7
Qualifications: nursing, teaching	1.3	2.0	4.0	1.4	-1.5	-0.8	-1.1	-1.6	-1.5	-1.2	-2.0	-1.4	-1.7	-0.8	-1.2
Commuting to job workplace: Walk	0.4	0.4	1.2	-0.2	0.1	0.9	-0.4	0.6	0.1	0.1	0.4	1.1	0.9	0.8	0.6
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.7	-0.8	-0.5	-1.0	-0.6	-0.8	-0.8	-0.1	-0.9	-0.6	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.9	1.1	-1.1	-1.3	-0.7	-1.4	-1.1	-1.1	-1.1	-1.1	-0.6	-0.8	-1.3
Medication for cholesterol	0.3	0.4	1.1	0.4	-0.7	-0.7	-0.9	0.2	-0.7	-0.1	0.8	-0.4	-0.3	-0.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.7	0.8	-0.8	-0.6	-0.6	-0.8	-0.8	-0.7	-0.7	-0.6	-0.5	-0.7	-0.7
Back pain experienced in last month	0.4	0.5	2.1	-0.5	0.5	-0.5	1.5	0.9	0.5	0.7	0.8	-0.5	-0.7	0.5	0.1
Mineral and other dietary supplements	1.4	1.9	5.8	1.5	-1.6	-0.4	-2.4	-1.3	-1.6	-1.5	-1.7	-0.8	-0.8	-0.7	-1.1
Breast cancer (self-reported)	2.3	2.8	4.9	1.6	-1.5	-1.5	-1.5	-2.0	-1.5	-1.6	-2.2	-1.6	-1.2	-1.8	-1.9
Asthma (self-reported)	0.6	1.3	2.6	-1.2	1.4	1.2	0.8	0.9	1.4	1.1	0.9	0.8	0.7	1.6	1.3
Osteoporosis (self-reported)	0.5	0.6	1.0	1.0	-1.0	-1.0	-0.5	-0.7	-1.0	-0.5	0.1	-0.8	-0.4	-0.6	-0.8
Osteoarthritis (self-reported)	0.3	0.4	1.5	0.4	-0.2	-1.2	1.0	-0.2	-0.2	0.1	0.8	-0.7	0.0	-1.0	-0.4
Medication: Aspirin	2.8	3.6	5.9	2.2	-2.0	-1.2	-1.5	-1.8	-2.0	-1.9	-2.4	-1.9	-2.2	-1.7	-1.7
Medication: Gliclazide	3.0	3.4	6.1	-1.6	1.9	1.0	2.3	2.2	1.9	1.7	2.5	1.5	1.1	2.0	1.9
Illnesses of father: None of the above (group 1)	0.6	0.7	2.9	-0.9	0.8	0.8	-0.1	1.0	0.8	0.7	1.7	0.5	-0.1	0.8	0.7
Smoking status: Current	2.4	3.9	6.9	-2.6	2.3	1.3	1.3	1.9	2.3	2.3	1.6	1.9	2.3	2.0	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.8	0.3	-0.1	0.0	1.1	0.4	-0.1	-0.2	0.1	-0.3	-1.3	-0.8	0.4
Whole body water mass	0.3	1.8	5.6	1.1	-1.3	-2.4	0.0	-0.8	-1.3	-0.3	-0.3	-2.0	-0.9	-1.5	-1.8
Leg predicted mass (right)	0.3	1.5	4.6	1.1	-1.2	-2.1	0.2	-0.9	-1.2	-0.3	-0.5	-1.9	-0.8	-1.3	-1.5
Arm fat mass (left)	0.3	1.4	6.6	0.4	-0.3	-2.6	1.9	-0.7	-0.3	0.2	1.0	-1.7	0.1	-1.1	-0.8
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.4	-0.1	-0.4	0.6	-0.3	-0.1	-0.1	0.0	-0.7	-0.5	-0.1	0.2
Average weekly champagne plus white wine intake	0.7	1.0	2.2	-1.0	0.9	0.5	0.6	1.0	0.9	1.1	1.2	0.8	1.2	1.5	0.9
Miserableness	0.2	0.4	2.3	-0.3	-0.2	-0.6	-0.5	-0.5	-0.2	0.4	-0.7	-0.2	1.5	-0.1	-0.8
Guilty feelings	0.6	0.8	2.7	-1.1	0.8	0.7	-0.4	0.4	0.8	0.9	0.3	0.8	1.6	1.4	0.5
Wears glasses or contact lenses	1.2	1.4	2.4	1.6	-1.4	-1.2	-0.2	-0.9	-1.4	-1.0	-1.3	-1.2	-1.1	-1.3	-1.0
Ever taken oral contraceptive pill	0.4	0.5	1.5	-0.7	0.7	0.1	0.5	0.4	0.7	0.5	0.8	0.4	1.2	1.0	0.4
Hearing aid user	0.2	0.2	0.7	-0.1	0.2	0.5	0.0	0.4	0.2	-0.5	-0.1	-0.1	-0.8	0.5	0.6
Mother’s age at death	0.5	0.6	3.7	0.1	-0.1	0.4	-1.0	1.1	-0.1	0.1	1.9	0.7	0.1	0.8	0.0
Financial situation satisfaction	0.6	0.7	2.0	0.4	-0.7	-0.7	-0.8	-1.3	-0.7	-0.2	-1.4	-0.6	0.4	-1.0	-1.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.2	1.2	-1.1	-0.9	-1.5	-0.3	-1.1	-0.9	-0.3	-0.6	-0.5	-1.1	-1.3
Commuting to job workplace: Public transport	2.7	3.2	4.3	2.0	-2.0	-1.1	-1.7	-1.7	-2.0	-1.9	-2.1	-1.8	-1.8	-1.7	-1.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	-0.1	0.4	0.9	0.6	0.5	0.4	0.4	0.1	0.7	-0.1	0.3	0.8
Medication: Blood pressure	0.3	0.6	2.5	0.7	-0.3	0.7	0.3	-0.3	-0.3	-0.9	-1.6	-0.2	-1.6	-0.3	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	0.2	-0.1	-0.8	0.6	-0.9	-0.1	-0.1	-0.9	-0.8	-0.2	-0.8	-0.3
Supplements: Fish oil (including cod liver oil)	6.2	8.1	16.6	-3.0	3.2	2.0	4.1	3.0	3.2	3.2	2.5	2.5	1.9	2.2	2.8
High cholesterol (Self-reported)	0.2	0.3	1.4	0.4	-0.2	-0.9	1.2	-0.3	-0.2	-0.0	-0.5	-0.7	-0.5	-0.7	-0.4
Medication: Bendroflumethiazide	1.1	1.6	3.5	1.6	-1.3	-0.7	-0.9	-1.7	-1.3	-1.4	-1.9	-1.0	-0.8	-1.3	-0.8
Medication: Paracetamol	0.0	0.1	0.2	-0.5	0.4	0.2	0.3	0.1	0.4	0.1	-0.2	0.1	0.2	-0.1	0.3
Medication: Lisinopril	0.9	1.1	2.4	-1.3	1.3	1.1	1.3	0.6	1.3	1.5	-0.5	1.0	0.8	0.4	1.0
Medication: Atorvastatin	0.3	0.4	2.7	0.4	0.2	-0.5	1.6	-0.1	0.2	0.0	0.3	-0.6	-0.7	0.0	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.9	-0.0	0.1	0.4	-1.0	-0.2	0.1	-0.4	-0.5	0.2	-0.1	0.4	-0.1
Alcohol drinker status: Never	0.3	0.3	0.8	-0.3	0.5	0.1	0.7	-0.8	0.5	-0.1	-0.8	0.4	0.9	-0.1	0.6
Ever smoked	0.5	0.9	2.3	0.3	-0.5	-1.3	-1.1	-1.3	-0.5	-0.2	-1.2	-0.9	0.7	-0.5	-1.5
Basal metabolic rate	0.3	1.4	5.3	0.9	-1.1	-2.3	0.4	-0.8	-1.1	-0.1	-0.1	-1.9	-0.6	-1.4	-1.5
Leg fat percentage (left)	0.3	1.2	6.5	-0.3	0.4	-1.9	2.5	-0.4	0.4	0.8	1.0	-1.0	0.6	-0.8	-0.1
Arm fat-free mass (left)	0.3	1.6	6.1	0.8	-1.1	-2.5	0.3	-1.0	-1.1	-0.1	-0.1	-1.9	-0.5	-1.6	-1.6
Number of operations (self-reported)	0.4	0.6	5.0	-0.2	0.3	-0.6	2.2	-0.1	0.3	0.5	0.7	-0.5	-0.0	-0.0	0.7
Average weekly beer plus cider intake	4.6	6.6	9.5	2.5	-2.5	-3.0	-2.4	-2.4	-2.5	-2.6	-1.4	-3.1	-2.3	-2.7	-3.0
Irritability	0.1	0.2	1.5	-0.1	-0.2	0.3	-1.2	0.1	-0.2	-0.0	0.2	0.4	0.7	0.6	-0.1
Risk taking	2.4	3.5	5.4	-2.1	1.6	1.1	1.7	2.1	1.6	2.3	1.9	1.9	2.0	2.0	1.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.6	0.8	-0.8	-1.6	-0.4	-1.2	-0.8	-0.7	-1.2	-1.5	-0.2	-1.2	-1.4
Fractured/broken bones in last 5 years	6.4	8.2	12.4	3.0	-3.0	-2.7	-2.8	-2.8	-3.0	-3.5	-2.0	-3.0	-2.8	-2.6	-2.8
Age started oral contraceptive pill	1.6	2.0	4.2	1.6	-1.5	-1.7	-0.8	-0.8	-1.5	-1.4	-0.2	-1.8	-2.1	-1.4	-1.4
Diastolic blood pressure, automated reading	1.0	3.0	4.5	2.1	-1.9	-1.8	-0.9	-1.5	-1.9	-1.9	-0.8	-2.0	-2.0	-2.1	-1.5
Ever depressed for a whole week	3.5	4.3	9.9	1.9	-2.1	-1.4	-2.3	-2.5	-2.1	-1.5	-3.1	-2.1	-1.4	-1.7	-2.0
Unable to work because of sickness or disability	0.3	0.4	1.1	0.3	-0.4	-0.9	0.5	-0.5	-0.4	0.3	-1.0	-0.7	-0.1	-0.6	-0.7
Commuting to job workplace: Cycle	4.4	5.4	10.0	2.4	-2.4	-2.0	-2.0	-3.0	-2.4	-2.2	-3.2	-2.2	-1.3	-1.7	-2.3
Myopia	2.1	3.1	8.5	2.0	-1.9	-0.8	-2.9	-1.3	-1.9	-2.3	-1.3	-1.1	-1.5	-1.0	-1.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.9	-1.8	1.4	1.1	-0.7	1.1	1.4	1.3	1.3	1.6	2.4	1.8	0.4
Cholesterol lowering medication	0.2	0.3	1.8	0.5	-0.2	-0.1	0.3	-1.0	-0.2	-0.6	-1.4	-0.5	-0.2	-0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	8.5	-1.6	2.0	1.0	2.9	0.8	2.0	1.6	-0.0	0.8	0.8	1.4	1.8
Pain experienced in last month	3.4	5.7	13.6	2.7	-2.6	-0.6	-3.7	-1.9	-2.6	-3.1	-2.5	-1.4	-2.3	-1.8	-2.0
Supplements: Calcium	0.6	0.7	3.1	-0.4	0.0	-1.5	0.4	0.3	0.0	0.6	1.7	-0.4	1.1	-0.2	-0.8
Basal cell carcinoma (self-reported)	1.7	2.0	2.8	1.6	-1.6	-1.4	-0.3	-1.4	-1.6	-1.1	-1.2	-1.6	-1.6	-1.7	-1.2
Heart attack/myocardial infarction (self-reported)	2.5	3.2	4.0	-2.0	2.0	1.8	1.9	1.9	2.0	2.0	1.1	1.8	1.2	1.8	1.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.8	1.1	-0.9	-0.9	-1.1	-1.7	-0.9	-0.8	-1.9	-0.6	0.3	-0.6	-1.4
Heart disease (siblings)	6.5	7.9	14.0	3.0	-2.9	-3.6	-1.1	-3.1	-2.9	-2.3	-1.8	-3.1	-1.8	-3.7	-3.1
Alcohol drinker status: Previous	1.8	2.0	4.3	1.8	-1.4	-0.2	-1.7	-1.6	-1.4	-1.7	-2.1	-0.8	-1.0	-1.3	-0.9
Pack years of smoking	0.3	0.5	1.1	-1.1	1.0	0.1	1.0	-0.2	1.0	0.8	-0.5	0.2	0.5	0.4	0.4
Impedance of whole body	0.5	2.5	7.8	-1.4	1.5	2.8	0.2	1.2	1.5	0.8	-0.0	2.1	0.7	2.1	2.0
Leg fat mass (left)	0.4	1.4	6.1	0.1	-0.1	-2.5	2.3	-0.6	-0.1	0.6	0.8	-1.6	0.2	-1.2	-0.7
Arm predicted mass (left)	0.4	1.9	6.6	1.0	-1.2	-2.6	0.0	-1.1	-1.2	-0.4	-0.3	-2.1	-0.7	-1.7	-1.8