Hub : Genes

LOC641367

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2640	0.0530	3.6e-15	0.169	0.173	0.186	0.185	0.180	4.4e-20	1.7e-20	4.6e-22	5.9e-22	2.3e-21
2	TCGA	Breast Invasive Carcinoma	0.0479	0.0224	3.1e-07	0.008	0.038	0.041	NA	0.034	7.9e-03	2.2e-08	8.2e-09	NA	1.1e-07
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0344	0.0200	3.9e-03	0.004	0.017	0.020	NA	0.011	9.7e-02	4.5e-03	2.2e-03	NA	2.0e-02
4	TCGA	Prostate Adenocarcinoma	0.0638	0.0332	1.8e-04	0.022	0.048	0.035	NA	0.030	1.9e-03	8.7e-06	1.2e-04	NA	3.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.9	-0.9	-1.4	-0.8	-1.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	-1.3	0.3	0.3	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.5	0.3	0.5	0.4
Depression (Nagel 2018)	0.0	0.1	0.1	0.4	-0.2	-0.3	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.4	1.2	0.0	0.1	-0.5
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.5	0.1	0.1	0.2
Schizophrenia (2018)	0.8	1.7	2.5	-0.9	1.5	1.1	1.6
Schizophrenia vs Biploar Disorder	0.5	0.7	2.7	-1.6	0.0	0.0	0.0
Worry (Nagel 2018)	0.7	1.5	2.8	0.5	1.7	1.1	1.2
Alzheimer’s Disease (in mother)	0.7	0.9	3.1	-1.8	-0.6	0.1	-0.2
Alzheimer’s Disease (in father)	1.7	1.9	3.6	1.4	1.0	1.0	1.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	-1.2	-0.2	0.5	0.9
Crohns Disease (2017)	1.4	3.2	4.5	1.5	2.1	1.8	1.7
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.1	1.0	0.9	0.5
Ulcerative Colitis (UC)	0.3	0.5	1.1	-1.0	-0.6	-0.4	-0.6
Major Depression (MDD)	0.2	0.3	1.0	-1.0	0.1	0.3	0.1
Reaction Time	0.1	0.2	0.3	-0.5	0.0	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	1.3	1.1	0.8	0.2
Breast Cancer	0.5	1.3	3.4	1.9	0.8	0.3	1.0
Ovarian Cancer	1.3	1.7	3.2	-1.8	-1.1	-0.8	-1.4
Prostate Cancer	0.1	0.2	0.5	-0.2	-0.2	-0.7	-0.4
Age at First Birth	1.3	1.9	3.2	0.4	1.7	1.2	1.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.5	-1.6	0.3	0.5	1.0
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.8	-0.4	0.3	-0.5
Crohns Disease (2012)	0.9	1.5	2.8	-0.4	1.4	1.7	1.1
Mean Putamen Volume	1.5	1.7	2.7	1.7	1.4	1.0	1.1
Fasting Glucose	0.5	0.6	1.4	-0.8	1.2	0.3	0.5
HbA1C	0.6	0.6	1.3	1.1	0.1	-1.1	-0.2
HDL Cholesterol	0.7	1.2	1.9	0.7	1.4	1.4	0.7
LDL Cholesterol	0.4	0.6	1.0	0.5	-0.9	-0.7	-1.0
Lupus	2.4	3.7	12.3	3.5	1.2	0.3	0.9
Neuroticism (2016)	1.2	1.8	2.9	-0.8	1.4	1.7	1.3
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.9	0.3	0.7	0.5
Rheumatoid Arthritis	1.8	2.4	4.4	-0.1	1.3	1.9	2.1
Schizophrenia (2014)	0.4	0.9	3.2	-1.8	0.3	0.4	0.5
Triglycerides	0.5	0.7	1.5	-1.2	0.4	1.0	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.0	0.2	0.7	0.3
Ulcerative Colitis	0.8	1.1	1.9	-0.7	-1.4	-0.8	-1.3
Blood Eosinophil Count	0.0	0.1	0.1	0.4	-0.3	-0.0	0.1
Blood Platelet Count	0.0	0.5	1.1	-0.5	-1.0	-0.1	-0.7
Blood Red Count	1.0	9.4	31.5	-5.6	0.4	2.0	1.3
Blood White Count	0.4	3.2	8.2	-2.9	-1.3	-0.5	-1.7
Heel T-Score	0.2	1.5	4.0	-2.0	-1.1	-0.4	-0.8
BMI	0.2	1.3	4.3	-2.1	-0.4	0.7	0.2
Height	0.1	1.4	4.0	2.0	-0.2	-0.8	-0.8
Waist Hip Ratio (WHR)	0.6	2.5	7.8	-2.8	-1.4	-0.3	-0.3
Systolic Blood Pressure	2.2	11.0	42.5	-6.5	-0.1	1.1	0.4
Smoking Status	0.2	0.5	1.0	-0.8	0.2	0.7	1.0
Allergy or Eczema	0.2	0.4	0.9	0.1	-0.5	-0.9	-0.8
Cardiovascular Disease	1.9	6.2	23.1	-4.8	-0.1	1.2	-0.4
Hypothyroidism (self reported)	0.7	1.6	2.9	0.6	1.6	0.6	1.7
Respiratory disease	0.7	1.6	2.4	-0.3	1.3	1.6	1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.6	-1.3	-1.1	-0.5	-1.2
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.0	-0.7	-0.6	-0.6
Lung FVC	0.1	0.7	1.4	0.3	-0.5	-1.2	-1.0
Neuroticism	0.1	0.3	0.8	-0.1	0.9	0.6	0.2
Chronotype (morning person)	0.2	0.5	0.8	0.8	-0.6	-0.6	-0.9
Hair Pigment	0.0	0.5	0.9	0.5	-0.2	-0.9	-0.9
Tanning	0.2	2.5	3.6	1.3	-1.3	-1.9	-1.8
Hand grip strength (left)	0.2	0.6	1.1	1.1	-0.3	-0.7	-0.9
Number of treatments/medications taken	1.3	2.3	3.7	-0.5	-1.9	-1.9	-1.3
Average weekly spirits intake	0.8	1.0	2.3	0.0	-1.5	-1.2	-0.5
Sensitivity / hurt feelings	1.2	2.0	2.6	1.4	-1.0	-1.6	-1.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.3	0.4	0.2	0.1
Hearing difficulty/problems: Yes	0.6	0.9	1.0	-0.9	-1.0	-0.8	-1.0
Relative age of first facial hair	1.3	2.6	5.7	2.4	-0.8	-1.3	-1.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.3	-0.5	0.1	0.6	1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.4	-1.6	0.1	-0.2	-0.1
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.7	0.0	-0.2	0.7
Systolic blood pressure, automated reading	2.1	6.0	14.4	-3.8	1.2	2.1	2.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	0.4	0.3	0.2
Angina	0.6	0.8	1.3	0.4	-1.1	-1.1	-0.8
Medication for hormone replacement therapy	2.8	3.1	4.1	-1.2	-2.0	-1.7	-2.0
Vitamin and mineral supplements	0.6	0.8	1.4	-1.2	-0.9	-0.2	-1.0
Supplements: Zinc	0.8	0.8	1.0	-0.9	0.8	0.9	1.0
Medication: Co-codamol	2.7	3.1	7.6	0.3	-2.8	-1.6	-1.4
Medication: Metformin	0.2	0.3	0.6	-0.2	-0.8	-0.3	-0.5
Diabetes (father)	0.8	1.0	1.7	-1.2	-1.3	-0.5	-0.8
Diabetes (mother)	1.1	1.3	2.8	-1.0	0.7	1.7	1.0
Severe depression (siblings)	0.7	0.8	1.5	1.2	0.7	0.4	1.1
Pack years adult smoking proportion	0.3	0.4	0.6	-0.8	-0.8	0.5	0.5
Impedance of leg (right)	0.1	0.6	1.5	1.2	0.0	-0.8	-0.4
Leg fat-free mass (left)	0.0	0.1	0.5	-0.1	0.1	0.7	0.0
Trunk fat percentage	0.1	0.6	1.4	-1.2	-1.0	0.0	-0.1
Hand grip strength (right)	0.4	1.0	2.7	1.6	0.1	-0.8	-0.8
Townsend deprivation index at recruitment	0.9	1.2	4.5	-2.1	-0.5	0.4	-0.1
Current tobacco smoking	0.3	0.4	1.6	-1.3	-0.0	0.4	0.2
Average weekly fortified wine intake	0.5	0.6	1.1	1.0	-0.2	-0.9	-0.8
Maternal smoking around birth	2.8	4.1	6.7	0.4	-1.9	-2.6	-2.4
Fed-up feelings	0.2	0.4	0.8	-0.9	0.6	0.7	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.2	0.5	-0.6	-1.1	-1.1
Relative age voice broke	0.9	1.4	5.1	2.3	0.5	-0.2	-0.6
Taking other prescription medications	0.2	0.4	0.9	-0.6	-0.4	-1.0	-0.3
Age when periods started (menarche)	0.7	1.7	2.0	1.2	-1.3	-1.4	-1.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.1	-0.5	-1.4	-1.3	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.7	-2.2	-0.2	0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	1.1	0.6	-0.0	-0.1
Qualifications: CSEs or equivalent	0.6	0.9	1.4	0.3	-1.0	-1.0	-1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.1	-0.2	-0.8	-1.0	-0.8
High blood pressure	1.2	3.2	9.7	-3.1	0.9	1.5	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.3	-0.5	-0.4	0.1
Multivitamins +/- minerals	0.2	0.2	0.4	0.2	0.7	0.3	0.6
Stomach or abdominal pain in last month	1.0	1.2	3.8	-1.9	0.2	0.9	0.5
Supplements: Glucosamine	0.3	0.4	1.3	1.1	0.4	0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	-0.2	0.7	0.7	0.8
Medication: Atenolol	0.7	0.9	1.7	-1.3	-0.7	-0.7	-1.0
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.2	1.1	0.2	0.7
Sitting height	0.0	0.2	0.4	-0.6	-0.1	0.2	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	-0.9	-0.3	0.1	-0.5
High blood pressure (mother)	1.4	1.9	3.9	-2.0	-0.0	1.7	0.9
Body mass index (BMI)	0.3	1.1	3.0	-1.7	0.1	1.1	0.6
Impedance of leg (left)	0.1	0.4	0.9	0.2	-0.4	-1.0	-0.8
Leg predicted mass (left)	0.0	0.1	0.5	-0.2	0.0	0.7	0.1
Trunk fat mass	0.1	0.5	1.3	-1.2	-0.9	-0.0	-0.1
Waist circumference	0.5	1.8	6.2	-2.5	-0.3	0.8	0.3
Number of incorrect matches in round	0.8	1.3	2.1	-0.0	1.0	1.5	1.4
Past tobacco smoking	0.2	0.4	1.5	1.2	0.4	0.0	0.3
Alcohol usually taken with meals	2.8	4.5	12.0	3.5	-0.9	-2.1	-1.0
Nervous feelings	1.1	2.1	3.4	0.9	1.6	1.3	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.8	0.6	0.3	0.2
Hearing difficulty/problems with background noise	1.9	3.1	4.7	-0.6	-2.2	-1.9	-1.9
Hair/balding pattern: Pattern 2	0.7	0.9	1.3	0.8	-0.8	-1.0	-1.1
Had menopause	1.7	2.1	8.1	2.8	0.2	-0.3	0.6
Had other major operations	2.3	2.9	4.6	-0.2	-1.8	-2.1	-1.9
Forced vital capacity (FVC)	0.3	1.1	2.4	0.7	-0.6	-1.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	5.5	-2.4	-0.5	-0.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	-0.1	-0.4	-0.4
Qualifications: None of the above	0.4	0.9	3.1	-1.8	0.2	0.7	-0.2
Financial difficulties in last 2 years	0.8	1.1	1.8	-1.4	0.5	1.1	1.1
Mouth/teeth dental problems	0.7	1.1	1.8	0.3	1.1	1.3	1.2
Heart attack	1.4	1.8	5.8	-2.4	-1.0	0.6	-0.1
Allergy	0.7	1.5	2.5	0.9	-1.0	-1.4	-1.6
Pain all over the body in last month	1.0	1.1	2.1	0.8	1.4	0.6	1.1
Diabetes (self-reported)	0.6	0.9	1.6	-0.4	-1.3	-1.0	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.3	0.1	-1.5	-0.9	-0.7
Medication: Ramipril	0.5	0.7	1.6	-1.3	-0.2	0.7	0.7
Medication: Simvastatin	0.2	0.3	0.7	-0.9	-0.8	0.1	-0.2
Fluid intelligence score	0.4	0.7	2.4	1.6	0.7	0.2	-0.1
Illnesses of siblings	0.8	1.1	2.2	0.5	-1.5	-1.3	-0.6
Neuroticism score	0.1	0.1	0.2	0.4	0.4	-0.2	-0.5
Weight	0.1	0.3	0.5	-0.7	-0.0	0.7	0.2
Impedance of arm (right)	0.3	1.4	3.0	1.7	-0.8	-1.3	-0.6
Arm fat percentage (right)	0.1	0.5	1.6	-1.3	-0.4	0.4	0.3
Trunk fat-free mass	0.0	0.2	0.4	0.3	0.6	0.5	0.1
Hip circumference	0.2	1.0	1.7	-0.3	0.9	1.3	1.2
Time employed in main current job	1.0	1.2	3.9	2.0	0.3	-0.3	-0.8
Alcohol intake versus 10 years previously	0.6	0.9	1.7	-0.8	0.0	1.1	1.3
Father’s age at death	1.5	2.0	3.3	1.8	-1.2	-1.6	-0.8
Worrier / anxious feelings	0.0	0.1	0.2	0.2	-0.4	-0.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	-1.2	0.6	0.4	0.9
Falls in the last year	0.4	0.5	0.9	-1.0	0.2	0.8	0.7
Hair/balding pattern: Pattern 3	1.2	1.8	2.5	-1.1	1.3	1.3	1.6
Number of live births	0.2	0.2	0.8	0.9	-0.0	-0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.1	0.5	-0.8	-1.4	-1.2
Pulse rate	0.5	0.9	3.3	-1.8	-0.3	0.4	0.2
Happiness	1.8	2.2	3.8	1.0	1.4	1.3	1.9
Noisy workplace	0.4	0.5	1.0	-0.6	0.5	1.0	0.6
Qualifications: A levels/AS levels or equivalent	1.2	2.6	9.1	3.0	1.0	0.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.2	0.6	0.6	0.2
Mouth/teeth dental problems: Dentures	2.1	3.5	5.3	-1.5	-1.9	-1.7	-2.3
Asthma	1.3	2.5	4.0	-0.9	1.5	2.0	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	-0.1	-1.3	-1.1	-0.6
Medication: Cholesterol lowering	1.2	1.9	3.1	-1.1	-1.8	-1.1	-1.5
Depression (self-reported)	0.5	0.6	2.0	1.4	0.4	-0.0	-0.6
Medication: Lansoprazole	1.8	2.0	7.5	-2.7	-0.7	-0.0	0.3
Prospective memory result	1.2	1.4	3.7	1.9	-0.7	-1.2	-0.5
Lung cancer (father)	0.4	0.4	0.8	0.8	0.0	-0.4	-0.9
Illnesses of mother	0.5	0.7	1.2	1.1	0.4	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.6	0.9	-0.3	-1.6	-1.0
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.5	0.4	-0.1	0.4
Impedance of arm (left)	0.3	1.5	3.4	1.8	-0.8	-1.3	-0.6
Arm fat mass (right)	0.1	0.4	1.2	-1.1	-0.4	0.4	0.2
Trunk predicted mass	0.0	0.2	0.4	0.3	0.6	0.4	0.0
Standing height	0.2	1.7	4.5	2.1	-0.5	-0.9	-1.0
Length of working week for main job	1.9	2.1	7.0	-2.6	-0.2	1.1	0.3
Exposure to tobacco smoke at home	1.0	1.1	2.3	0.1	-1.0	-1.0	-1.5
Breastfed as a baby	1.0	1.3	1.7	-0.3	-1.3	-1.3	-1.3
Tense / ‘highly strung’	0.4	0.6	0.9	-0.9	1.0	0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.7	0.3	0.1	0.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.4	-0.1	0.2	0.3
Birth weight of first child	0.1	0.2	0.7	0.8	0.2	0.5	0.1
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.4	0.3	-0.2	-0.7
Pulse wave reflection index	0.2	0.3	0.4	0.5	0.6	0.1	0.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.9	1.4	0.9	0.4	0.5
Loud music exposure frequency	0.9	1.0	1.9	-1.4	-1.3	0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.7	1.6	0.3	0.0	-0.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.0	1.3	1.2	1.0	1.4
Blood clot in the leg (DVT)	0.4	0.6	1.0	0.3	1.0	0.6	1.0
Medication: Paracetamol	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.5
Headache pain in last month	0.2	0.4	0.7	-0.8	-0.7	0.0	0.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.1	1.8	1.4	0.3	1.5
Glaucoma (self-reported)	3.1	3.6	12.0	-3.5	-0.0	1.6	-0.1
Gout (self-reported)	0.6	0.8	2.7	-1.6	-0.5	0.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	1.2	0.6	-0.5	0.6
Medication: Amlodipine	1.9	2.7	9.1	-3.0	0.3	0.5	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.2	0.3	0.7	0.3
Birth weight	0.3	0.7	2.0	0.4	1.4	0.9	0.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.9	2.2	0.9	-0.5	0.1
High blood pressure (siblings)	0.5	0.8	1.5	0.2	1.2	1.1	0.7
Forced vital capacity (FVC), Best measure	0.3	1.2	2.8	0.8	-0.3	-1.7	-1.1
Body fat percentage	0.1	0.6	1.8	-1.3	-0.7	0.2	0.2
Leg fat percentage (right)	0.2	0.8	2.2	-1.5	0.2	0.9	0.6
Arm fat-free mass (right)	0.0	0.1	0.3	-0.5	0.2	0.5	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.3	0.2	0.3	0.4
Comparative body size at age 10	0.1	0.3	0.9	-0.9	0.2	-0.0	0.4
Number of full brothers	0.7	0.8	1.3	1.0	-1.1	-1.0	-0.3
Worry too long after embarrassment	0.9	1.6	2.7	-0.9	-1.4	-0.8	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.2	1.6	1.8	1.0	1.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.1	-1.5	0.9	0.8	1.2
Number of children fathered	0.3	0.3	0.9	0.0	-1.0	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	2.6	1.0	1.6	1.4	1.2
Age at first live birth	0.8	1.5	4.7	2.2	0.2	-0.9	-0.6
Pulse wave peak to peak time	0.2	0.2	0.7	0.8	-0.2	0.1	-0.3
Health satisfaction	0.1	0.1	0.2	-0.3	-0.2	0.3	0.4
Shortness of breath walking on level ground	0.3	0.3	0.9	-0.3	-0.9	0.1	-0.6
Qualifications: College or University degree	0.7	2.1	4.7	2.2	-1.0	-1.2	-1.0
Eye problems/disorders: None of the above	0.6	0.7	2.2	1.5	-0.3	-0.5	0.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.3	0.6	-1.8	-1.5	-1.1
Emphysema/chronic bronchitis	1.0	1.1	2.7	-1.6	0.5	0.9	0.8
Medication for pain relief, constipation, heartburn	1.2	2.0	5.0	0.7	2.2	1.4	0.7
Neck or shoulder pain in last month	0.6	0.9	1.5	1.0	-0.7	-1.2	-0.7
Medication: Blood pressure	0.5	1.0	1.9	-1.4	-0.8	0.1	-1.2
Angina (self-reported)	0.7	0.9	1.4	0.4	-1.2	-1.2	-0.8
Migraine (self-reported)	0.1	0.1	0.2	-0.2	-0.4	0.3	0.4
Medication: Ibuprofen	0.3	0.3	0.9	-1.0	-0.5	-0.2	0.1
Medication: Allopurinol	0.7	0.9	2.8	-1.7	-0.6	-0.1	-0.6
Medication: Omeprazole	0.3	0.3	0.4	0.7	0.1	0.6	0.7
Medication: Seretide 50 evohaler	0.3	0.3	0.8	-0.6	-0.9	-0.1	-0.2
Mean time to correctly identify matches	0.0	0.1	0.1	-0.2	-0.2	-0.0	0.4
Heart disease (mother)	0.2	0.2	0.5	-0.7	-0.0	0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.1	0.3	0.4	0.1
Whole body fat mass	0.1	0.5	1.5	-1.2	-0.5	0.4	0.1
Leg fat mass (right)	0.2	0.6	1.8	-1.4	-0.2	0.7	0.3
Arm predicted mass (right)	0.0	0.2	0.4	-0.5	0.2	0.6	-0.2
Pulse rate, automated reading	0.4	1.4	5.1	-2.3	-0.7	0.0	-0.2
Alcohol intake frequency.	0.3	0.7	1.4	-1.2	-1.2	0.0	-0.1
Comparative height size at age 10	0.0	0.3	0.3	0.5	-0.6	-0.5	-0.5
Number of full sisters	0.2	0.2	0.6	0.8	0.4	0.3	-0.0
Suffer from ‘nerves’	1.7	2.7	4.0	1.5	2.0	1.7	1.3
Overall health rating	0.5	1.1	2.8	-0.9	0.6	0.8	1.7
Chest pain or discomfort	0.3	0.5	1.1	-0.8	0.1	1.0	0.5
Had major operations	1.2	1.4	3.2	0.3	-1.8	-0.8	-1.3
Age at last live birth	0.3	0.4	1.2	1.1	0.6	0.0	-0.2
Family relationship satisfaction	2.0	2.5	4.4	1.4	1.3	1.4	2.1
Leg pain on walking	4.4	5.5	8.8	-0.3	-3.0	-2.8	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.2	0.2	0.1	0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	0.2	-1.1	-0.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	-1.1	-0.5	-0.1	-0.0
Medication: Aspirin	1.1	1.5	2.8	-1.7	-1.5	-0.8	-0.4
Supplements: Vitamin C	0.1	0.1	0.3	0.2	-0.2	-0.5	0.2
Knee pain experienced in last month	0.1	0.1	0.3	-0.4	-0.5	-0.1	-0.0
Hypertension (Self-reported)	1.1	3.0	9.9	-3.1	0.7	1.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.2	-1.8	-0.1	0.6	0.0
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	0.0	0.1	0.5
Illnesses of siblings: Diabetes	1.0	1.2	2.2	-1.1	1.2	1.5	0.5
Smoking status: Previous	0.2	0.3	0.6	-0.8	0.3	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	0.0	-0.2	-0.3	-1.2
Whole body fat-free mass	0.0	0.1	0.3	0.0	0.4	0.6	-0.0
Leg fat-free mass (right)	0.0	0.1	0.3	-0.4	-0.1	0.6	-0.2
Arm fat percentage (left)	0.1	0.5	1.7	-1.3	-0.4	0.4	0.3
Average weekly red wine intake	2.7	4.0	10.0	3.2	-0.8	-1.8	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-0.9	-0.3	0.1	1.3
Mood swings	0.3	0.6	1.5	0.0	1.2	0.6	0.7
Loneliness, isolation	0.3	0.4	0.6	0.5	0.7	0.5	0.7
Long-standing illness, disability or infirmity	0.5	0.8	2.0	-0.9	0.3	0.5	1.4
Ever had bowel cancer screening	2.5	2.9	7.1	1.3	1.4	1.1	2.7
Diabetes diagnosed by doctor	0.4	0.7	1.0	-0.8	-1.0	-0.6	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.8	0.1	-0.4	-0.4
Friendships satisfaction	3.4	4.2	6.7	0.5	2.1	2.3	2.6
Qualifications: nursing, teaching	1.2	1.9	6.6	2.6	0.4	0.1	0.9
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.4	-0.7	-0.6	-0.6
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.1	-0.1	0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.0	-0.8	-0.7	-0.9	-1.0
Medication for cholesterol	1.3	2.0	6.8	2.6	-0.3	-1.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	0.3	0.4	0.1	0.8
Back pain experienced in last month	0.4	0.5	1.4	-0.1	-1.2	-0.8	-0.2
Mineral and other dietary supplements	0.4	0.5	1.0	-1.0	-0.3	-0.3	-0.9
Breast cancer (self-reported)	2.1	2.5	4.5	2.1	-0.6	-2.1	-0.9
Asthma (self-reported)	1.4	2.8	4.2	-0.8	1.8	2.1	1.8
Osteoporosis (self-reported)	0.5	0.6	1.8	1.4	-0.1	-0.5	0.4
Osteoarthritis (self-reported)	0.5	0.7	1.3	-0.6	-1.0	-1.1	-0.4
Medication: Aspirin	1.0	1.3	2.3	-1.5	-1.5	-0.9	-0.4
Medication: Gliclazide	0.2	0.3	0.9	-0.1	-1.0	-0.3	-0.3
Illnesses of father: None of the above (group 1)	1.7	2.1	3.4	1.6	-0.7	-1.5	-1.8
Smoking status: Current	0.2	0.4	1.2	-1.1	-0.5	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	0.2	1.1	-0.1	1.4
Whole body water mass	0.0	0.1	0.4	-0.2	0.4	0.6	0.1
Leg predicted mass (right)	0.0	0.1	0.2	-0.4	-0.2	0.5	-0.3
Arm fat mass (left)	0.1	0.4	1.2	-1.1	-0.1	0.6	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	-1.0	0.5	0.4	0.5
Average weekly champagne plus white wine intake	2.1	2.9	4.0	0.9	-1.7	-2.0	-2.0
Miserableness	0.2	0.4	1.3	1.1	0.4	-0.2	-0.0
Guilty feelings	0.3	0.5	1.2	-0.4	-0.1	-0.7	-1.1
Wears glasses or contact lenses	0.3	0.3	0.7	-0.9	-0.0	-0.7	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.6	-0.3	-0.3	-0.7
Hearing aid user	0.5	0.6	1.0	0.9	-0.7	-1.0	-0.3
Mother’s age at death	1.5	1.9	4.2	2.0	1.5	0.3	1.1
Financial situation satisfaction	1.7	2.2	3.3	-1.8	1.4	1.7	0.8
Tinnitus: Yes, now most or all of the time	2.7	3.1	5.2	1.2	-2.0	-2.3	-1.4
Commuting to job workplace: Public transport	0.5	0.6	1.2	-0.4	1.1	1.0	0.3
Eye problems/disorders: Glaucoma	2.8	3.3	6.8	-2.6	1.2	2.1	0.7
Medication: Blood pressure	1.4	2.6	8.1	-2.8	0.6	1.3	0.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.4	-1.3	0.5	0.8	1.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	1.2	-0.1	-0.0	0.7
High cholesterol (Self-reported)	2.4	4.3	15.0	-3.9	-1.4	0.1	-0.5
Medication: Bendroflumethiazide	0.9	1.4	5.2	-2.3	-0.4	0.2	-0.2
Medication: Paracetamol	0.1	0.2	0.5	0.3	0.2	-0.2	0.7
Medication: Lisinopril	1.3	1.7	5.8	-2.4	-0.5	0.5	-0.6
Medication: Atorvastatin	1.8	2.2	3.5	-1.6	-1.9	-1.2	-1.2
Illnesses of father: High blood pressure	1.5	1.8	2.7	-1.1	1.1	1.5	1.6
Alcohol drinker status: Never	1.1	1.4	1.5	1.2	-1.1	-1.1	-1.2
Ever smoked	0.2	0.4	1.3	-1.1	-0.1	0.3	0.1
Basal metabolic rate	0.0	0.2	0.6	-0.2	0.4	0.8	0.2
Leg fat percentage (left)	0.4	1.5	5.1	-2.3	-0.0	0.8	0.4
Arm fat-free mass (left)	0.0	0.2	0.5	-0.3	0.4	0.7	0.2
Number of operations (self-reported)	1.4	2.1	4.8	-0.5	-2.2	-1.5	-1.0
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.1	-0.1	0.4	0.2
Irritability	0.0	0.1	0.2	0.1	0.2	-0.2	0.5
Risk taking	1.2	1.7	3.7	-1.9	0.7	1.1	1.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.5	0.8	1.1	0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.7	-0.1	-0.4	0.8	0.4
Age started oral contraceptive pill	0.3	0.4	0.8	0.2	0.2	0.7	0.9
Diastolic blood pressure, automated reading	2.2	6.8	22.0	-4.7	0.1	1.9	1.3
Ever depressed for a whole week	1.2	1.4	3.8	1.9	-0.8	-1.0	-0.6
Unable to work because of sickness or disability	0.3	0.4	0.6	0.6	-0.3	-0.6	-0.8
Commuting to job workplace: Cycle	0.8	1.0	2.1	-0.7	-0.9	-0.8	-1.4
Myopia	0.8	1.2	3.1	0.9	1.8	0.7	0.8
Vascular/heart problems diagnosed by doctor	1.1	3.0	11.0	3.3	-0.3	-0.9	-0.1
Cholesterol lowering medication	2.2	3.3	7.2	-2.7	0.4	2.1	1.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.1	1.0	0.8	0.9	1.1
Pain experienced in last month	0.2	0.4	1.0	0.3	1.0	0.1	-0.7
Supplements: Calcium	0.1	0.1	0.2	-0.3	0.4	0.4	0.3
Basal cell carcinoma (self-reported)	2.0	2.4	6.1	-0.7	1.2	1.3	2.5
Heart attack/myocardial infarction (self-reported)	1.4	1.8	6.0	-2.4	-1.0	0.5	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.2	0.7	0.3	0.8
Heart disease (siblings)	0.2	0.3	0.9	-0.9	-0.4	-0.1	-0.4
Alcohol drinker status: Previous	1.6	1.8	3.0	-1.1	1.2	1.7	1.2
Pack years of smoking	0.4	0.6	1.3	-1.1	-0.8	0.5	0.4
Impedance of whole body	0.3	1.3	2.0	1.1	-1.1	-1.4	-1.0
Leg fat mass (left)	0.3	1.2	4.2	-2.0	-0.4	0.8	0.2
Arm predicted mass (left)	0.0	0.3	0.6	-0.5	0.4	0.8	0.1