Hub : Genes

LOC641367

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2640 0.0530 3.6e-15 0.169 0.173 0.186 0.185 0.180 4.4e-20 1.7e-20 4.6e-22 5.9e-22 2.3e-21
2 TCGA Breast Invasive Carcinoma 0.0479 0.0224 3.1e-07 0.008 0.038 0.041 NA 0.034 7.9e-03 2.2e-08 8.2e-09 NA 1.1e-07
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0344 0.0200 3.9e-03 0.004 0.017 0.020 NA 0.011 9.7e-02 4.5e-03 2.2e-03 NA 2.0e-02
4 TCGA Prostate Adenocarcinoma 0.0638 0.0332 1.8e-04 0.022 0.048 0.035 NA 0.030 1.9e-03 8.7e-06 1.2e-04 NA 3.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 1.9 -0.9 -1.4 -0.8 -1.1
Bipolar Disorder or Schizophrenia 0.2 0.5 1.6 -1.3 0.3 0.3 0.6
Depressed Affect (Nagel 2018) 0.1 0.2 0.3 -0.5 0.3 0.5 0.4
Depression (Nagel 2018) 0.0 0.1 0.1 0.4 -0.2 -0.3 -0.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.4 1.2 0.0 0.1 -0.5
Neuroticism (Nagel 2018) 0.0 0.1 0.2 -0.5 0.1 0.1 0.2
Schizophrenia (2018) 0.8 1.7 2.5 -0.9 1.5 1.1 1.6
Schizophrenia vs Biploar Disorder 0.5 0.7 2.7 -1.6 0.0 0.0 0.0
Worry (Nagel 2018) 0.7 1.5 2.8 0.5 1.7 1.1 1.2
Alzheimer’s Disease (in mother) 0.7 0.9 3.1 -1.8 -0.6 0.1 -0.2
Alzheimer’s Disease (in father) 1.7 1.9 3.6 1.4 1.0 1.0 1.9
Alzheimer’s Disease (including proxy) 0.4 0.6 1.4 -1.2 -0.2 0.5 0.9
Crohns Disease (2017) 1.4 3.2 4.5 1.5 2.1 1.8 1.7
Irritable Bowel Disease (IBD) 0.2 0.5 0.9 0.1 1.0 0.9 0.5
Ulcerative Colitis (UC) 0.3 0.5 1.1 -1.0 -0.6 -0.4 -0.6
Major Depression (MDD) 0.2 0.3 1.0 -1.0 0.1 0.3 0.1
Reaction Time 0.1 0.2 0.3 -0.5 0.0 0.3 0.5
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.6 1.3 1.1 0.8 0.2
Breast Cancer 0.5 1.3 3.4 1.9 0.8 0.3 1.0
Ovarian Cancer 1.3 1.7 3.2 -1.8 -1.1 -0.8 -1.4
Prostate Cancer 0.1 0.2 0.5 -0.2 -0.2 -0.7 -0.4
Age at First Birth 1.3 1.9 3.2 0.4 1.7 1.2 1.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.2 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 2.5 -1.6 0.3 0.5 1.0
Coronary Artery Disease (CAD) 0.2 0.3 0.7 -0.8 -0.4 0.3 -0.5
Crohns Disease (2012) 0.9 1.5 2.8 -0.4 1.4 1.7 1.1
Mean Putamen Volume 1.5 1.7 2.7 1.7 1.4 1.0 1.1
Fasting Glucose 0.5 0.6 1.4 -0.8 1.2 0.3 0.5
HbA1C 0.6 0.6 1.3 1.1 0.1 -1.1 -0.2
HDL Cholesterol 0.7 1.2 1.9 0.7 1.4 1.4 0.7
LDL Cholesterol 0.4 0.6 1.0 0.5 -0.9 -0.7 -1.0
Lupus 2.4 3.7 12.3 3.5 1.2 0.3 0.9
Neuroticism (2016) 1.2 1.8 2.9 -0.8 1.4 1.7 1.3
Primary Biliary Cirrhosis 0.3 0.4 0.8 0.9 0.3 0.7 0.5
Rheumatoid Arthritis 1.8 2.4 4.4 -0.1 1.3 1.9 2.1
Schizophrenia (2014) 0.4 0.9 3.2 -1.8 0.3 0.4 0.5
Triglycerides 0.5 0.7 1.5 -1.2 0.4 1.0 0.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 0.0 0.2 0.7 0.3
Ulcerative Colitis 0.8 1.1 1.9 -0.7 -1.4 -0.8 -1.3
Blood Eosinophil Count 0.0 0.1 0.1 0.4 -0.3 -0.0 0.1
Blood Platelet Count 0.0 0.5 1.1 -0.5 -1.0 -0.1 -0.7
Blood Red Count 1.0 9.4 31.5 -5.6 0.4 2.0 1.3
Blood White Count 0.4 3.2 8.2 -2.9 -1.3 -0.5 -1.7
Heel T-Score 0.2 1.5 4.0 -2.0 -1.1 -0.4 -0.8
BMI 0.2 1.3 4.3 -2.1 -0.4 0.7 0.2
Height 0.1 1.4 4.0 2.0 -0.2 -0.8 -0.8
Waist Hip Ratio (WHR) 0.6 2.5 7.8 -2.8 -1.4 -0.3 -0.3
Systolic Blood Pressure 2.2 11.0 42.5 -6.5 -0.1 1.1 0.4
Smoking Status 0.2 0.5 1.0 -0.8 0.2 0.7 1.0
Allergy or Eczema 0.2 0.4 0.9 0.1 -0.5 -0.9 -0.8
Cardiovascular Disease 1.9 6.2 23.1 -4.8 -0.1 1.2 -0.4
Hypothyroidism (self reported) 0.7 1.6 2.9 0.6 1.6 0.6 1.7
Respiratory disease 0.7 1.6 2.4 -0.3 1.3 1.6 1.5
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.6 -1.3 -1.1 -0.5 -1.2
Lung FEV1/FVC ratio 0.1 0.3 0.5 -0.0 -0.7 -0.6 -0.6
Lung FVC 0.1 0.7 1.4 0.3 -0.5 -1.2 -1.0
Neuroticism 0.1 0.3 0.8 -0.1 0.9 0.6 0.2
Chronotype (morning person) 0.2 0.5 0.8 0.8 -0.6 -0.6 -0.9
Hair Pigment 0.0 0.5 0.9 0.5 -0.2 -0.9 -0.9
Tanning 0.2 2.5 3.6 1.3 -1.3 -1.9 -1.8
Hand grip strength (left) 0.2 0.6 1.1 1.1 -0.3 -0.7 -0.9
Number of treatments/medications taken 1.3 2.3 3.7 -0.5 -1.9 -1.9 -1.3
Average weekly spirits intake 0.8 1.0 2.3 0.0 -1.5 -1.2 -0.5
Sensitivity / hurt feelings 1.2 2.0 2.6 1.4 -1.0 -1.6 -1.5
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.3 0.4 0.2 0.1
Hearing difficulty/problems: Yes 0.6 0.9 1.0 -0.9 -1.0 -0.8 -1.0
Relative age of first facial hair 1.3 2.6 5.7 2.4 -0.8 -1.3 -1.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 2.3 -0.5 0.1 0.6 1.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.4 -1.6 0.1 -0.2 -0.1
Ever had hysterectomy (womb removed) 0.2 0.3 0.6 -0.7 0.0 -0.2 0.7
Systolic blood pressure, automated reading 2.1 6.0 14.4 -3.8 1.2 2.1 2.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 -0.2 0.4 0.3 0.2
Angina 0.6 0.8 1.3 0.4 -1.1 -1.1 -0.8
Medication for hormone replacement therapy 2.8 3.1 4.1 -1.2 -2.0 -1.7 -2.0
Vitamin and mineral supplements 0.6 0.8 1.4 -1.2 -0.9 -0.2 -1.0
Supplements: Zinc 0.8 0.8 1.0 -0.9 0.8 0.9 1.0
Medication: Co-codamol 2.7 3.1 7.6 0.3 -2.8 -1.6 -1.4
Medication: Metformin 0.2 0.3 0.6 -0.2 -0.8 -0.3 -0.5
Diabetes (father) 0.8 1.0 1.7 -1.2 -1.3 -0.5 -0.8
Diabetes (mother) 1.1 1.3 2.8 -1.0 0.7 1.7 1.0
Severe depression (siblings) 0.7 0.8 1.5 1.2 0.7 0.4 1.1
Pack years adult smoking proportion 0.3 0.4 0.6 -0.8 -0.8 0.5 0.5
Impedance of leg (right) 0.1 0.6 1.5 1.2 0.0 -0.8 -0.4
Leg fat-free mass (left) 0.0 0.1 0.5 -0.1 0.1 0.7 0.0
Trunk fat percentage 0.1 0.6 1.4 -1.2 -1.0 0.0 -0.1
Hand grip strength (right) 0.4 1.0 2.7 1.6 0.1 -0.8 -0.8
Townsend deprivation index at recruitment 0.9 1.2 4.5 -2.1 -0.5 0.4 -0.1
Current tobacco smoking 0.3 0.4 1.6 -1.3 -0.0 0.4 0.2
Average weekly fortified wine intake 0.5 0.6 1.1 1.0 -0.2 -0.9 -0.8
Maternal smoking around birth 2.8 4.1 6.7 0.4 -1.9 -2.6 -2.4
Fed-up feelings 0.2 0.4 0.8 -0.9 0.6 0.7 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 1.2 0.5 -0.6 -1.1 -1.1
Relative age voice broke 0.9 1.4 5.1 2.3 0.5 -0.2 -0.6
Taking other prescription medications 0.2 0.4 0.9 -0.6 -0.4 -1.0 -0.3
Age when periods started (menarche) 0.7 1.7 2.0 1.2 -1.3 -1.4 -1.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 2.1 -0.5 -1.4 -1.3 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 4.7 -2.2 -0.2 0.2 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 1.1 0.6 -0.0 -0.1
Qualifications: CSEs or equivalent 0.6 0.9 1.4 0.3 -1.0 -1.0 -1.2
Serious illness, injury or assault to yourself 0.5 0.6 1.1 -0.2 -0.8 -1.0 -0.8
High blood pressure 1.2 3.2 9.7 -3.1 0.9 1.5 0.3
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.2 0.3 -0.5 -0.4 0.1
Multivitamins +/- minerals 0.2 0.2 0.4 0.2 0.7 0.3 0.6
Stomach or abdominal pain in last month 1.0 1.2 3.8 -1.9 0.2 0.9 0.5
Supplements: Glucosamine 0.3 0.4 1.3 1.1 0.4 0.1 0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.7 -0.2 0.7 0.7 0.8
Medication: Atenolol 0.7 0.9 1.7 -1.3 -0.7 -0.7 -1.0
Medication: Levothyroxine sodium 0.3 0.5 1.2 0.2 1.1 0.2 0.7
Sitting height 0.0 0.2 0.4 -0.6 -0.1 0.2 -0.5
Chronic bronchitis/emphysema (father) 0.2 0.3 0.8 -0.9 -0.3 0.1 -0.5
High blood pressure (mother) 1.4 1.9 3.9 -2.0 -0.0 1.7 0.9
Body mass index (BMI) 0.3 1.1 3.0 -1.7 0.1 1.1 0.6
Impedance of leg (left) 0.1 0.4 0.9 0.2 -0.4 -1.0 -0.8
Leg predicted mass (left) 0.0 0.1 0.5 -0.2 0.0 0.7 0.1
Trunk fat mass 0.1 0.5 1.3 -1.2 -0.9 -0.0 -0.1
Waist circumference 0.5 1.8 6.2 -2.5 -0.3 0.8 0.3
Number of incorrect matches in round 0.8 1.3 2.1 -0.0 1.0 1.5 1.4
Past tobacco smoking 0.2 0.4 1.5 1.2 0.4 0.0 0.3
Alcohol usually taken with meals 2.8 4.5 12.0 3.5 -0.9 -2.1 -1.0
Nervous feelings 1.1 2.1 3.4 0.9 1.6 1.3 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.7 -0.8 0.6 0.3 0.2
Hearing difficulty/problems with background noise 1.9 3.1 4.7 -0.6 -2.2 -1.9 -1.9
Hair/balding pattern: Pattern 2 0.7 0.9 1.3 0.8 -0.8 -1.0 -1.1
Had menopause 1.7 2.1 8.1 2.8 0.2 -0.3 0.6
Had other major operations 2.3 2.9 4.6 -0.2 -1.8 -2.1 -1.9
Forced vital capacity (FVC) 0.3 1.1 2.4 0.7 -0.6 -1.5 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 5.5 -2.4 -0.5 -0.1 -0.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.4 0.6 -0.1 -0.4 -0.4
Qualifications: None of the above 0.4 0.9 3.1 -1.8 0.2 0.7 -0.2
Financial difficulties in last 2 years 0.8 1.1 1.8 -1.4 0.5 1.1 1.1
Mouth/teeth dental problems 0.7 1.1 1.8 0.3 1.1 1.3 1.2
Heart attack 1.4 1.8 5.8 -2.4 -1.0 0.6 -0.1
Allergy 0.7 1.5 2.5 0.9 -1.0 -1.4 -1.6
Pain all over the body in last month 1.0 1.1 2.1 0.8 1.4 0.6 1.1
Diabetes (self-reported) 0.6 0.9 1.6 -0.4 -1.3 -1.0 -1.0
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.3 0.1 -1.5 -0.9 -0.7
Medication: Ramipril 0.5 0.7 1.6 -1.3 -0.2 0.7 0.7
Medication: Simvastatin 0.2 0.3 0.7 -0.9 -0.8 0.1 -0.2
Fluid intelligence score 0.4 0.7 2.4 1.6 0.7 0.2 -0.1
Illnesses of siblings 0.8 1.1 2.2 0.5 -1.5 -1.3 -0.6
Neuroticism score 0.1 0.1 0.2 0.4 0.4 -0.2 -0.5
Weight 0.1 0.3 0.5 -0.7 -0.0 0.7 0.2
Impedance of arm (right) 0.3 1.4 3.0 1.7 -0.8 -1.3 -0.6
Arm fat percentage (right) 0.1 0.5 1.6 -1.3 -0.4 0.4 0.3
Trunk fat-free mass 0.0 0.2 0.4 0.3 0.6 0.5 0.1
Hip circumference 0.2 1.0 1.7 -0.3 0.9 1.3 1.2
Time employed in main current job 1.0 1.2 3.9 2.0 0.3 -0.3 -0.8
Alcohol intake versus 10 years previously 0.6 0.9 1.7 -0.8 0.0 1.1 1.3
Father’s age at death 1.5 2.0 3.3 1.8 -1.2 -1.6 -0.8
Worrier / anxious feelings 0.0 0.1 0.2 0.2 -0.4 -0.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 -1.2 0.6 0.4 0.9
Falls in the last year 0.4 0.5 0.9 -1.0 0.2 0.8 0.7
Hair/balding pattern: Pattern 3 1.2 1.8 2.5 -1.1 1.3 1.3 1.6
Number of live births 0.2 0.2 0.8 0.9 -0.0 -0.3 0.3
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.1 0.5 -0.8 -1.4 -1.2
Pulse rate 0.5 0.9 3.3 -1.8 -0.3 0.4 0.2
Happiness 1.8 2.2 3.8 1.0 1.4 1.3 1.9
Noisy workplace 0.4 0.5 1.0 -0.6 0.5 1.0 0.6
Qualifications: A levels/AS levels or equivalent 1.2 2.6 9.1 3.0 1.0 0.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.2 0.6 0.6 0.2
Mouth/teeth dental problems: Dentures 2.1 3.5 5.3 -1.5 -1.9 -1.7 -2.3
Asthma 1.3 2.5 4.0 -0.9 1.5 2.0 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.6 -0.1 -1.3 -1.1 -0.6
Medication: Cholesterol lowering 1.2 1.9 3.1 -1.1 -1.8 -1.1 -1.5
Depression (self-reported) 0.5 0.6 2.0 1.4 0.4 -0.0 -0.6
Medication: Lansoprazole 1.8 2.0 7.5 -2.7 -0.7 -0.0 0.3
Prospective memory result 1.2 1.4 3.7 1.9 -0.7 -1.2 -0.5
Lung cancer (father) 0.4 0.4 0.8 0.8 0.0 -0.4 -0.9
Illnesses of mother 0.5 0.7 1.2 1.1 0.4 -0.9 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 2.6 0.9 -0.3 -1.6 -1.0
Pulse wave Arterial Stiffness index 0.1 0.1 0.3 -0.5 0.4 -0.1 0.4
Impedance of arm (left) 0.3 1.5 3.4 1.8 -0.8 -1.3 -0.6
Arm fat mass (right) 0.1 0.4 1.2 -1.1 -0.4 0.4 0.2
Trunk predicted mass 0.0 0.2 0.4 0.3 0.6 0.4 0.0
Standing height 0.2 1.7 4.5 2.1 -0.5 -0.9 -1.0
Length of working week for main job 1.9 2.1 7.0 -2.6 -0.2 1.1 0.3
Exposure to tobacco smoke at home 1.0 1.1 2.3 0.1 -1.0 -1.0 -1.5
Breastfed as a baby 1.0 1.3 1.7 -0.3 -1.3 -1.3 -1.3
Tense / ‘highly strung’ 0.4 0.6 0.9 -0.9 1.0 0.7 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.5 0.7 0.3 0.1 0.6
Hair/balding pattern: Pattern 4 0.0 0.1 0.1 -0.4 -0.1 0.2 0.3
Birth weight of first child 0.1 0.2 0.7 0.8 0.2 0.5 0.1
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.4 0.3 -0.2 -0.7
Pulse wave reflection index 0.2 0.3 0.4 0.5 0.6 0.1 0.6
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.9 1.4 0.9 0.4 0.5
Loud music exposure frequency 0.9 1.0 1.9 -1.4 -1.3 0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 2.7 1.6 0.3 0.0 -0.1
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 2.0 1.3 1.2 1.0 1.4
Blood clot in the leg (DVT) 0.4 0.6 1.0 0.3 1.0 0.6 1.0
Medication: Paracetamol 0.0 0.1 0.2 -0.1 -0.1 -0.1 0.5
Headache pain in last month 0.2 0.4 0.7 -0.8 -0.7 0.0 0.6
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.1 1.8 1.4 0.3 1.5
Glaucoma (self-reported) 3.1 3.6 12.0 -3.5 -0.0 1.6 -0.1
Gout (self-reported) 0.6 0.8 2.7 -1.6 -0.5 0.4 -0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.4 1.2 0.6 -0.5 0.6
Medication: Amlodipine 1.9 2.7 9.1 -3.0 0.3 0.5 -1.1
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.5 0.2 0.3 0.7 0.3
Birth weight 0.3 0.7 2.0 0.4 1.4 0.9 0.2
Chronic bronchitis/emphysema (mother) 1.3 1.5 4.9 2.2 0.9 -0.5 0.1
High blood pressure (siblings) 0.5 0.8 1.5 0.2 1.2 1.1 0.7
Forced vital capacity (FVC), Best measure 0.3 1.2 2.8 0.8 -0.3 -1.7 -1.1
Body fat percentage 0.1 0.6 1.8 -1.3 -0.7 0.2 0.2
Leg fat percentage (right) 0.2 0.8 2.2 -1.5 0.2 0.9 0.6
Arm fat-free mass (right) 0.0 0.1 0.3 -0.5 0.2 0.5 -0.1
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.3 0.2 0.3 0.4
Comparative body size at age 10 0.1 0.3 0.9 -0.9 0.2 -0.0 0.4
Number of full brothers 0.7 0.8 1.3 1.0 -1.1 -1.0 -0.3
Worry too long after embarrassment 0.9 1.6 2.7 -0.9 -1.4 -0.8 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 3.2 1.6 1.8 1.0 1.2
Wheeze or whistling in the chest in last year 0.7 1.2 2.1 -1.5 0.9 0.8 1.2
Number of children fathered 0.3 0.3 0.9 0.0 -1.0 -0.4 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 2.6 1.0 1.6 1.4 1.2
Age at first live birth 0.8 1.5 4.7 2.2 0.2 -0.9 -0.6
Pulse wave peak to peak time 0.2 0.2 0.7 0.8 -0.2 0.1 -0.3
Health satisfaction 0.1 0.1 0.2 -0.3 -0.2 0.3 0.4
Shortness of breath walking on level ground 0.3 0.3 0.9 -0.3 -0.9 0.1 -0.6
Qualifications: College or University degree 0.7 2.1 4.7 2.2 -1.0 -1.2 -1.0
Eye problems/disorders: None of the above 0.6 0.7 2.2 1.5 -0.3 -0.5 0.2
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.3 0.6 -1.8 -1.5 -1.1
Emphysema/chronic bronchitis 1.0 1.1 2.7 -1.6 0.5 0.9 0.8
Medication for pain relief, constipation, heartburn 1.2 2.0 5.0 0.7 2.2 1.4 0.7
Neck or shoulder pain in last month 0.6 0.9 1.5 1.0 -0.7 -1.2 -0.7
Medication: Blood pressure 0.5 1.0 1.9 -1.4 -0.8 0.1 -1.2
Angina (self-reported) 0.7 0.9 1.4 0.4 -1.2 -1.2 -0.8
Migraine (self-reported) 0.1 0.1 0.2 -0.2 -0.4 0.3 0.4
Medication: Ibuprofen 0.3 0.3 0.9 -1.0 -0.5 -0.2 0.1
Medication: Allopurinol 0.7 0.9 2.8 -1.7 -0.6 -0.1 -0.6
Medication: Omeprazole 0.3 0.3 0.4 0.7 0.1 0.6 0.7
Medication: Seretide 50 evohaler 0.3 0.3 0.8 -0.6 -0.9 -0.1 -0.2
Mean time to correctly identify matches 0.0 0.1 0.1 -0.2 -0.2 -0.0 0.4
Heart disease (mother) 0.2 0.2 0.5 -0.7 -0.0 0.5 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 0.1 0.3 0.4 0.1
Whole body fat mass 0.1 0.5 1.5 -1.2 -0.5 0.4 0.1
Leg fat mass (right) 0.2 0.6 1.8 -1.4 -0.2 0.7 0.3
Arm predicted mass (right) 0.0 0.2 0.4 -0.5 0.2 0.6 -0.2
Pulse rate, automated reading 0.4 1.4 5.1 -2.3 -0.7 0.0 -0.2
Alcohol intake frequency. 0.3 0.7 1.4 -1.2 -1.2 0.0 -0.1
Comparative height size at age 10 0.0 0.3 0.3 0.5 -0.6 -0.5 -0.5
Number of full sisters 0.2 0.2 0.6 0.8 0.4 0.3 -0.0
Suffer from ‘nerves’ 1.7 2.7 4.0 1.5 2.0 1.7 1.3
Overall health rating 0.5 1.1 2.8 -0.9 0.6 0.8 1.7
Chest pain or discomfort 0.3 0.5 1.1 -0.8 0.1 1.0 0.5
Had major operations 1.2 1.4 3.2 0.3 -1.8 -0.8 -1.3
Age at last live birth 0.3 0.4 1.2 1.1 0.6 0.0 -0.2
Family relationship satisfaction 2.0 2.5 4.4 1.4 1.3 1.4 2.1
Leg pain on walking 4.4 5.5 8.8 -0.3 -3.0 -2.8 -2.2
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.2 0.2 0.1 0.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.2 0.2 -1.1 -0.9 -0.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.2 -1.1 -0.5 -0.1 -0.0
Medication: Aspirin 1.1 1.5 2.8 -1.7 -1.5 -0.8 -0.4
Supplements: Vitamin C 0.1 0.1 0.3 0.2 -0.2 -0.5 0.2
Knee pain experienced in last month 0.1 0.1 0.3 -0.4 -0.5 -0.1 -0.0
Hypertension (Self-reported) 1.1 3.0 9.9 -3.1 0.7 1.3 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.2 -1.8 -0.1 0.6 0.0
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.5 0.0 0.1 0.5
Illnesses of siblings: Diabetes 1.0 1.2 2.2 -1.1 1.2 1.5 0.5
Smoking status: Previous 0.2 0.3 0.6 -0.8 0.3 0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.4 0.0 -0.2 -0.3 -1.2
Whole body fat-free mass 0.0 0.1 0.3 0.0 0.4 0.6 -0.0
Leg fat-free mass (right) 0.0 0.1 0.3 -0.4 -0.1 0.6 -0.2
Arm fat percentage (left) 0.1 0.5 1.7 -1.3 -0.4 0.4 0.3
Average weekly red wine intake 2.7 4.0 10.0 3.2 -0.8 -1.8 -1.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 -0.9 -0.3 0.1 1.3
Mood swings 0.3 0.6 1.5 0.0 1.2 0.6 0.7
Loneliness, isolation 0.3 0.4 0.6 0.5 0.7 0.5 0.7
Long-standing illness, disability or infirmity 0.5 0.8 2.0 -0.9 0.3 0.5 1.4
Ever had bowel cancer screening 2.5 2.9 7.1 1.3 1.4 1.1 2.7
Diabetes diagnosed by doctor 0.4 0.7 1.0 -0.8 -1.0 -0.6 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 -0.8 0.1 -0.4 -0.4
Friendships satisfaction 3.4 4.2 6.7 0.5 2.1 2.3 2.6
Qualifications: nursing, teaching 1.2 1.9 6.6 2.6 0.4 0.1 0.9
Commuting to job workplace: Walk 0.3 0.3 0.5 -0.4 -0.7 -0.6 -0.6
Eye problems/disorders: Cataract 0.0 0.0 0.0 0.1 -0.1 0.2 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.0 -0.8 -0.7 -0.9 -1.0
Medication for cholesterol 1.3 2.0 6.8 2.6 -0.3 -1.1 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 0.3 0.4 0.1 0.8
Back pain experienced in last month 0.4 0.5 1.4 -0.1 -1.2 -0.8 -0.2
Mineral and other dietary supplements 0.4 0.5 1.0 -1.0 -0.3 -0.3 -0.9
Breast cancer (self-reported) 2.1 2.5 4.5 2.1 -0.6 -2.1 -0.9
Asthma (self-reported) 1.4 2.8 4.2 -0.8 1.8 2.1 1.8
Osteoporosis (self-reported) 0.5 0.6 1.8 1.4 -0.1 -0.5 0.4
Osteoarthritis (self-reported) 0.5 0.7 1.3 -0.6 -1.0 -1.1 -0.4
Medication: Aspirin 1.0 1.3 2.3 -1.5 -1.5 -0.9 -0.4
Medication: Gliclazide 0.2 0.3 0.9 -0.1 -1.0 -0.3 -0.3
Illnesses of father: None of the above (group 1) 1.7 2.1 3.4 1.6 -0.7 -1.5 -1.8
Smoking status: Current 0.2 0.4 1.2 -1.1 -0.5 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 0.2 1.1 -0.1 1.4
Whole body water mass 0.0 0.1 0.4 -0.2 0.4 0.6 0.1
Leg predicted mass (right) 0.0 0.1 0.2 -0.4 -0.2 0.5 -0.3
Arm fat mass (left) 0.1 0.4 1.2 -1.1 -0.1 0.6 0.4
Number of self-reported non-cancer illnesses 0.2 0.4 0.9 -1.0 0.5 0.4 0.5
Average weekly champagne plus white wine intake 2.1 2.9 4.0 0.9 -1.7 -2.0 -2.0
Miserableness 0.2 0.4 1.3 1.1 0.4 -0.2 -0.0
Guilty feelings 0.3 0.5 1.2 -0.4 -0.1 -0.7 -1.1
Wears glasses or contact lenses 0.3 0.3 0.7 -0.9 -0.0 -0.7 -0.2
Ever taken oral contraceptive pill 0.2 0.2 0.5 -0.6 -0.3 -0.3 -0.7
Hearing aid user 0.5 0.6 1.0 0.9 -0.7 -1.0 -0.3
Mother’s age at death 1.5 1.9 4.2 2.0 1.5 0.3 1.1
Financial situation satisfaction 1.7 2.2 3.3 -1.8 1.4 1.7 0.8
Tinnitus: Yes, now most or all of the time 2.7 3.1 5.2 1.2 -2.0 -2.3 -1.4
Commuting to job workplace: Public transport 0.5 0.6 1.2 -0.4 1.1 1.0 0.3
Eye problems/disorders: Glaucoma 2.8 3.3 6.8 -2.6 1.2 2.1 0.7
Medication: Blood pressure 1.4 2.6 8.1 -2.8 0.6 1.3 0.7
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.4 -1.3 0.5 0.8 1.9
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.4 1.2 -0.1 -0.0 0.7
High cholesterol (Self-reported) 2.4 4.3 15.0 -3.9 -1.4 0.1 -0.5
Medication: Bendroflumethiazide 0.9 1.4 5.2 -2.3 -0.4 0.2 -0.2
Medication: Paracetamol 0.1 0.2 0.5 0.3 0.2 -0.2 0.7
Medication: Lisinopril 1.3 1.7 5.8 -2.4 -0.5 0.5 -0.6
Medication: Atorvastatin 1.8 2.2 3.5 -1.6 -1.9 -1.2 -1.2
Illnesses of father: High blood pressure 1.5 1.8 2.7 -1.1 1.1 1.5 1.6
Alcohol drinker status: Never 1.1 1.4 1.5 1.2 -1.1 -1.1 -1.2
Ever smoked 0.2 0.4 1.3 -1.1 -0.1 0.3 0.1
Basal metabolic rate 0.0 0.2 0.6 -0.2 0.4 0.8 0.2
Leg fat percentage (left) 0.4 1.5 5.1 -2.3 -0.0 0.8 0.4
Arm fat-free mass (left) 0.0 0.2 0.5 -0.3 0.4 0.7 0.2
Number of operations (self-reported) 1.4 2.1 4.8 -0.5 -2.2 -1.5 -1.0
Average weekly beer plus cider intake 0.0 0.0 0.1 -0.1 -0.1 0.4 0.2
Irritability 0.0 0.1 0.2 0.1 0.2 -0.2 0.5
Risk taking 1.2 1.7 3.7 -1.9 0.7 1.1 1.2
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.1 0.5 0.8 1.1 0.6
Fractured/broken bones in last 5 years 0.2 0.2 0.7 -0.1 -0.4 0.8 0.4
Age started oral contraceptive pill 0.3 0.4 0.8 0.2 0.2 0.7 0.9
Diastolic blood pressure, automated reading 2.2 6.8 22.0 -4.7 0.1 1.9 1.3
Ever depressed for a whole week 1.2 1.4 3.8 1.9 -0.8 -1.0 -0.6
Unable to work because of sickness or disability 0.3 0.4 0.6 0.6 -0.3 -0.6 -0.8
Commuting to job workplace: Cycle 0.8 1.0 2.1 -0.7 -0.9 -0.8 -1.4
Myopia 0.8 1.2 3.1 0.9 1.8 0.7 0.8
Vascular/heart problems diagnosed by doctor 1.1 3.0 11.0 3.3 -0.3 -0.9 -0.1
Cholesterol lowering medication 2.2 3.3 7.2 -2.7 0.4 2.1 1.2
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 1.1 1.0 0.8 0.9 1.1
Pain experienced in last month 0.2 0.4 1.0 0.3 1.0 0.1 -0.7
Supplements: Calcium 0.1 0.1 0.2 -0.3 0.4 0.4 0.3
Basal cell carcinoma (self-reported) 2.0 2.4 6.1 -0.7 1.2 1.3 2.5
Heart attack/myocardial infarction (self-reported) 1.4 1.8 6.0 -2.4 -1.0 0.5 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 0.2 0.7 0.3 0.8
Heart disease (siblings) 0.2 0.3 0.9 -0.9 -0.4 -0.1 -0.4
Alcohol drinker status: Previous 1.6 1.8 3.0 -1.1 1.2 1.7 1.2
Pack years of smoking 0.4 0.6 1.3 -1.1 -0.8 0.5 0.4
Impedance of whole body 0.3 1.3 2.0 1.1 -1.1 -1.4 -1.0
Leg fat mass (left) 0.3 1.2 4.2 -2.0 -0.4 0.8 0.2
Arm predicted mass (left) 0.0 0.3 0.6 -0.5 0.4 0.8 0.1