TWAS hub - LOC646999

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0152	0.0091	9.2e-03	0.011	0.001	0.000	NA	0.004	1.8e-03	1.5e-01	3.1e-01	NA	3.6e-02
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0497	0.0250	1.1e-03	-0.001	0.014	0.003	NA	0.008	3.9e-01	8.5e-03	1.2e-01	NA	3.8e-02
3	TCGA	Brain Lower Grade Glioma	0.0830	0.0461	4.0e-04	0.010	0.030	0.022	NA	0.009	2.2e-02	2.2e-04	1.4e-03	NA	2.9e-02
4	TCGA	Prostate Adenocarcinoma	0.0283	0.0165	8.6e-03	0.013	0.012	0.004	NA	0.009	1.4e-02	1.6e-02	1.1e-01	NA	3.1e-02
5	TCGA	Stomach Adenocarcinoma	0.0810	0.0400	7.3e-04	0.005	0.031	0.026	NA	0.024	1.2e-01	2.3e-03	4.9e-03	NA	7.0e-03
6	TCGA	Thyroid Carcinoma	0.0700	0.0310	1.9e-05	0.063	0.053	0.052	NA	0.055	1.0e-06	6.0e-06	7.4e-06	NA	4.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Fluid intelligence score	6.6	13.7	17.4	-4.1	-3.7	-3.4	-3.5	-3.3	-4.2
Verbal and Numeric Reasoning (VNR)	6.4	15.3	18.3	-4.2	-3.6	-3.8	-4.0	-3.6	-4.3
Intelligence (Savage-Jansen 2018)	4.8	14.8	16.9	-4.1	-3.5	-3.8	-3.8	-3.8	-4.1
Noisy workplace	4.8	5.9	7.0	2.3	2.4	2.5	2.6	2.5	2.3
Financial situation satisfaction	4.7	5.8	8.2	2.5	1.9	2.0	2.9	2.7	2.5
Hand grip strength (left)	4.5	11.8	14.5	-3.8	-3.1	-3.1	-3.4	-3.3	-3.8
Medication: Gliclazide	4.5	5.1	11.0	-3.3	-1.4	-1.4	-1.1	-1.9	-3.3
Myopia	4.3	6.3	9.9	-2.5	-3.1	-2.6	-1.7	-2.3	-2.6
Impedance of arm (left)	4.2	19.3	26.9	4.0	4.7	5.2	4.4	4.0	4.0
Impedance of arm (right)	3.7	17.3	26.5	3.7	4.3	5.2	4.1	3.8	3.8
Arm predicted mass (right)	3.3	17.1	28.3	-3.5	-4.3	-5.3	-3.7	-4.0	-3.6
Basal cell carcinoma (self-reported)	3.2	3.8	6.6	-1.7	-1.8	-1.8	-2.6	-2.0	-1.7
Qualifications: None of the above	3.1	6.7	10.6	2.5	1.9	2.0	3.2	3.1	2.5
Impedance of whole body	3.1	15.8	22.4	3.7	3.9	4.7	4.0	3.7	3.7
Medication: Metformin	3.0	4.3	6.3	-2.5	-1.7	-2.3	-1.5	-1.7	-2.5
Medication: Amlodipine	3.0	4.2	6.9	1.4	2.1	2.6	2.4	1.9	1.5
Arm fat-free mass (right)	3.0	15.6	26.3	-3.4	-4.1	-5.1	-3.5	-3.8	-3.5
Ever depressed for a whole week	3.0	3.7	6.1	1.7	2.5	2.2	1.6	1.6	1.8
Commuting to job workplace: Public transport	2.9	3.5	5.7	-1.6	-2.0	-1.3	-2.4	-2.1	-1.6
Arm fat-free mass (left)	2.9	14.9	24.4	-3.4	-4.0	-4.9	-3.5	-3.7	-3.4
Medication: Omeprazole (e.g. Zanprol)	2.9	3.5	6.3	-2.0	-2.5	-2.0	-1.2	-1.2	-2.0
Primary Biliary Cirrhosis	2.8	4.1	8.3	-1.5	-1.3	-2.3	-2.1	-2.9	-1.5
Average weekly champagne plus white wine intake	2.8	3.9	4.9	-2.2	-1.7	-1.5	-2.2	-2.0	-2.1
Hypothyroidism (self reported)	2.7	6.3	15.1	1.6	2.2	1.9	3.9	3.0	1.6
Number of full brothers	2.7	3.5	7.4	2.7	1.7	0.7	1.1	1.3	2.7
Smoking status: Previous	2.7	4.0	5.9	-1.8	-1.8	-2.0	-2.3	-2.4	-1.8
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.7	-1.5	-0.6	-1.0	-2.5	-2.6	-1.5
Waist circumference	2.6	9.4	17.9	-2.5	-3.9	-4.2	-1.9	-2.5	-2.6
Length of working week for main job	2.6	2.9	6.3	1.1	1.8	1.4	2.5	1.8	1.1
Emphysema/chronic bronchitis	2.6	2.9	7.3	-1.8	-0.2	-1.0	-1.7	-2.7	-1.8
Leg fat mass (right)	2.5	9.6	18.6	-2.3	-4.3	-4.2	-2.3	-2.3	-2.4
Osteoporosis (self-reported)	2.5	3.1	4.1	2.0	1.3	1.2	1.9	2.0	1.9
Chronic bronchitis/emphysema (father)	2.4	2.8	4.2	-2.0	-0.9	-1.9	-1.1	-1.7	-2.0
Past tobacco smoking	2.4	4.5	6.7	2.1	1.5	1.8	2.4	2.6	2.1
Migraine (self-reported)	2.4	2.9	4.9	2.1	2.1	1.6	-0.4	0.9	2.2
Medication: Omeprazole	2.4	2.9	4.3	-1.9	-2.1	-1.5	-1.4	-1.1	-1.9
Type 2 Diabetes (T2D) (2018)	2.3	4.4	5.4	-2.2	-2.2	-2.3	-1.9	-1.6	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	5.7	1.2	1.5	1.2	2.4	2.0	1.2
Breast cancer (self-reported)	2.3	2.8	4.0	2.0	1.1	0.9	1.9	1.7	2.0
Leg fat mass (left)	2.3	8.9	18.4	-2.2	-4.3	-3.9	-2.3	-2.1	-2.3
Arm predicted mass (left)	2.3	11.8	20.8	-2.9	-3.6	-4.6	-3.2	-3.2	-2.9
Trunk fat-free mass	2.2	12.6	21.0	-3.1	-3.4	-4.6	-3.3	-3.6	-3.1
Hip circumference	2.2	9.5	17.2	-2.8	-3.7	-4.2	-2.1	-2.4	-2.8
Trunk predicted mass	2.2	12.4	20.8	-3.1	-3.3	-4.6	-3.3	-3.6	-3.1
Glaucoma (self-reported)	2.2	2.6	6.1	-1.4	-2.5	-1.7	-0.8	-1.2	-1.5
Whole body water mass	2.2	12.6	22.0	-3.1	-3.6	-4.7	-3.0	-3.4	-3.2
Body mass index (BMI)	2.1	8.8	14.6	-2.6	-3.8	-3.8	-2.3	-2.1	-2.7
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	10.3	1.3	1.4	1.1	3.2	2.7	1.3
Chronic bronchitis/emphysema (mother)	2.1	2.5	3.5	1.3	1.9	1.7	1.7	1.3	1.4
Bipolar Disorder (2018)	2.0	3.2	10.2	0.9	1.4	1.4	3.2	1.9	0.9
Shortness of breath walking on level ground	2.0	2.4	7.3	0.6	1.0	1.1	2.7	2.0	0.6
Whole body fat-free mass	2.0	11.5	20.7	-2.9	-3.5	-4.5	-2.9	-3.2	-3.0
Hearing aid user	2.0	2.3	3.5	1.3	1.9	1.7	1.3	1.4	1.4
Basal metabolic rate	2.0	11.2	20.2	-2.9	-3.6	-4.5	-2.7	-3.0	-3.0
Crohns Disease (2012)	1.9	3.0	4.3	-1.5	-1.4	-1.8	-1.9	-2.1	-1.6
Weight	1.9	9.3	16.5	-2.6	-3.6	-4.1	-2.4	-2.5	-2.7
Average weekly beer plus cider intake	1.9	2.7	5.2	1.4	1.3	1.0	2.3	2.1	1.3
Prostate Cancer	1.8	2.6	4.1	-1.9	-2.0	-1.2	-1.0	-1.3	-1.9
Leg fat-free mass (left)	1.8	9.5	18.2	-2.6	-3.4	-4.3	-2.3	-2.7	-2.7
Hand grip strength (right)	1.8	4.9	5.6	-2.4	-1.9	-2.0	-2.2	-2.3	-2.3
Medication: Cholesterol lowering	1.8	2.7	4.1	-1.9	-2.0	-1.2	-1.4	-1.3	-1.9
Birth weight	1.8	3.9	4.2	-2.0	-2.0	-1.9	-1.8	-2.0	-2.1
Leg fat percentage (right)	1.8	6.6	14.2	-1.8	-3.8	-3.4	-1.9	-1.8	-1.9
Worry too long after embarrassment	1.8	3.1	5.8	-1.1	-1.7	-1.9	-2.4	-1.9	-1.1
Neck or shoulder pain in last month	1.8	2.6	4.8	2.2	1.5	0.1	1.2	1.5	2.2
Had major operations	1.8	2.1	3.6	0.7	1.7	1.7	1.9	1.5	0.7
Supplements: Calcium	1.8	2.0	5.1	-2.3	-0.4	-0.8	0.4	-1.1	-2.2
Bipolar Disorder (2011)	1.7	1.6	6.1	0.9	0.3	-0.2	2.5	1.4	0.8
Coronary Artery Disease (CAD)	1.7	2.0	5.2	-1.0	-0.7	-1.4	-2.3	-1.7	-0.6
Leg predicted mass (left)	1.7	9.1	17.8	-2.5	-3.4	-4.2	-2.3	-2.7	-2.6
Heart disease (mother)	1.7	2.1	4.9	-0.3	-1.1	-1.6	-2.2	-1.9	-0.3
Leg fat percentage (left)	1.7	6.2	14.5	-1.8	-3.8	-3.1	-2.0	-1.4	-2.0
Pain all over the body in last month	1.6	1.7	2.7	1.6	1.1	0.8	1.4	1.2	1.6
Long-standing illness, disability or infirmity	1.6	2.5	4.0	-2.0	-0.4	-1.6	-1.1	-1.7	-2.0
Back pain experienced in last month	1.6	2.4	5.1	-0.4	-1.5	-2.2	-2.0	-1.6	-0.4
Eye problems/disorders: Glaucoma	1.6	1.9	3.6	-1.4	-1.9	-1.5	-0.5	-1.1	-1.4
Lung FVC	1.5	7.7	14.6	-2.1	-2.2	-2.8	-3.8	-3.1	-2.2
Medication: Co-codamol	1.5	1.7	2.6	1.2	1.1	1.6	0.9	1.6	1.2
Pack years adult smoking proportion	1.5	2.2	3.4	1.6	0.6	1.3	1.9	1.7	1.6
Medication: Levothyroxine sodium	1.5	2.5	6.8	0.9	1.4	0.8	2.6	2.0	0.9
Whole body fat mass	1.5	6.1	12.3	-1.8	-3.5	-3.3	-1.9	-1.8	-1.9
Mother’s age at death	1.5	1.9	2.6	-1.4	-1.2	-1.4	-1.3	-1.6	-1.4
Alcohol drinker status: Never	1.5	1.8	2.9	1.7	1.2	0.8	1.0	1.6	1.7
Medication for hormone replacement therapy	1.4	1.5	2.5	-1.6	-0.6	-0.5	-1.4	-1.2	-1.5
Qualifications: College or University degree	1.4	4.5	7.5	-2.7	-1.4	-1.5	-2.3	-1.7	-2.6
Pack years of smoking	1.4	2.0	2.7	1.6	0.5	1.3	1.6	1.6	1.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.1	1.2	1.8	1.1	1.7	1.5	1.3
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.5	-1.5	-1.0	-1.3	-1.1	-1.1	-1.6
Exposure to tobacco smoke outside home	1.3	1.7	3.6	0.8	1.9	1.7	1.1	1.0	0.8
Number of children fathered	1.3	1.4	3.2	0.9	1.6	1.8	0.4	0.9	1.0
Leg fat-free mass (right)	1.3	6.9	13.0	-2.3	-3.0	-3.6	-2.0	-2.1	-2.4
Leg predicted mass (right)	1.3	7.0	13.3	-2.3	-3.0	-3.6	-2.0	-2.1	-2.4
High cholesterol (Self-reported)	1.3	2.3	4.6	-1.1	-2.1	-1.2	-1.7	-1.6	-1.1
Heart disease (siblings)	1.3	1.5	3.4	1.9	1.1	0.7	0.5	0.8	1.8
BMI	1.2	6.8	13.3	-2.4	-3.3	-3.6	-1.7	-1.4	-2.4
Arm fat mass (left)	1.2	5.0	9.0	-1.8	-3.0	-3.0	-1.6	-1.6	-1.9
Mean Putamen Volume	1.1	1.2	2.4	-1.2	-1.6	-1.3	0.2	-0.1	-1.3
Systolic blood pressure, automated reading	1.1	3.3	8.3	-1.2	-2.0	-1.1	-2.9	-1.8	-1.2
Medication: Simvastatin	1.1	1.7	4.0	-1.2	-1.1	-0.8	-2.0	-1.2	-1.1
Arm fat mass (right)	1.1	4.6	9.4	-1.6	-3.1	-2.9	-1.5	-1.4	-1.7
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.2	1.4	0.4	1.1	0.7	1.5	1.3
Ever smoked	1.1	2.0	3.8	-1.2	-1.0	-1.2	-1.9	-1.7	-1.2
Smoking Status	1.0	2.4	4.4	-1.9	-0.5	-0.6	-1.7	-2.1	-1.8
Trunk fat mass	1.0	4.5	9.1	-1.6	-3.0	-2.7	-1.6	-1.6	-1.7
Heart attack	1.0	1.2	3.1	0.5	0.5	1.5	1.1	1.8	0.5
Diabetes (self-reported)	1.0	1.6	4.1	-1.1	-0.8	-1.0	-2.0	-1.0	-1.1
Supplements: Vitamin C	1.0	1.1	3.3	0.4	1.1	1.0	1.8	1.0	0.4
Multivitamins +/- minerals	0.9	1.1	2.1	1.1	1.4	1.1	0.6	1.0	1.0
Medication: Atenolol	0.9	1.1	1.7	1.2	1.0	0.6	1.3	0.9	1.2
Impedance of leg (left)	0.9	4.5	6.7	2.0	1.6	2.6	2.3	2.1	2.0
Alcohol usually taken with meals	0.9	1.4	4.0	-0.9	-0.5	-0.9	-2.0	-1.4	-0.8
Nervous feelings	0.9	1.7	3.9	2.0	1.0	0.8	0.3	0.9	1.9
Medication: Lansoprazole	0.9	1.0	1.4	-1.1	-1.2	-0.4	-1.2	-1.0	-1.1
Body fat percentage	0.9	3.4	9.0	-1.2	-3.0	-2.4	-1.3	-1.0	-1.3
Diastolic blood pressure, automated reading	0.9	2.7	5.6	-1.0	-2.4	-1.8	-1.6	-1.6	-1.0
Unable to work because of sickness or disability	0.9	1.2	3.4	-0.6	-1.5	-1.9	-0.3	-0.8	-0.7
Ulcerative Colitis (UC)	0.8	1.5	4.2	-0.8	-0.3	-1.0	-2.1	-1.6	-0.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.7	-1.2	0.2	-0.9	-0.8	-1.3	-1.1
Townsend deprivation index at recruitment	0.8	1.1	4.6	-0.7	-0.4	-0.1	2.1	1.0	-0.7
Time employed in main current job	0.8	0.9	4.0	0.1	0.0	-0.3	-2.0	-1.1	0.2
Loud music exposure frequency	0.8	0.9	2.0	0.8	0.8	0.6	1.4	1.2	0.7
Headache pain in last month	0.8	1.4	3.2	1.7	0.6	1.0	-0.2	0.8	1.8
High blood pressure (siblings)	0.8	1.1	1.8	1.2	1.3	0.2	1.2	0.7	1.2
Alcohol intake frequency.	0.8	1.8	2.7	1.6	1.5	0.8	1.4	0.9	1.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.1	-1.4	-1.4	-0.5	0.3	0.0	-1.4
Medication: Bendroflumethiazide	0.8	1.2	2.2	-1.2	-0.8	-0.6	-0.9	-1.5	-1.2
Impedance of leg (right)	0.7	3.6	4.7	2.0	1.6	2.1	2.2	1.6	2.0
Arm fat percentage (right)	0.7	2.6	6.9	-1.2	-2.6	-2.0	-1.0	-0.8	-1.2
Alcohol intake versus 10 years previously	0.7	1.1	3.1	0.7	1.2	0.7	1.8	0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	0.2	0.1	-1.1	-1.3	-1.2	0.3
Exposure to tobacco smoke at home	0.7	0.8	1.4	-1.2	-0.5	-0.8	-0.3	-0.9	-1.2
Diabetes diagnosed by doctor	0.7	1.2	1.9	-1.2	-0.7	-1.1	-1.4	-0.8	-1.2
Irritability	0.7	1.1	1.5	-1.2	-1.2	-1.0	-0.8	-0.7	-1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	0.5	0.5	1.3	0.8	1.5	0.5
Bipolar Disorder or Schizophrenia	0.6	1.4	5.8	0.3	0.7	1.0	2.4	1.1	0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	1.0	0.4	1.3	-0.3	0.7	1.1
Irritable Bowel Disease (IBD)	0.6	1.5	3.8	-0.9	-0.3	-1.0	-1.9	-1.5	-0.9
LDL Cholesterol	0.6	0.9	1.9	0.9	0.6	0.6	1.1	1.4	0.8
Lupus	0.6	0.8	1.3	1.2	0.9	0.9	0.8	0.4	1.2
Systolic Blood Pressure	0.6	3.2	5.5	-1.6	-2.0	-1.2	-2.3	-1.9	-1.6
Vitamin and mineral supplements	0.6	0.8	1.4	-0.7	-1.2	-1.1	-0.9	-0.8	-0.7
Number of incorrect matches in round	0.6	1.0	2.2	0.5	0.4	1.4	1.1	1.5	0.5
Had menopause	0.6	0.8	1.7	0.6	1.3	0.6	-1.1	-0.7	0.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	1.4	1.0	0.2	0.6	0.6	1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	1.0	1.3	1.1	0.8	0.8	1.0
Depression (self-reported)	0.6	0.7	1.6	0.5	0.1	1.2	1.2	1.0	0.6
Gout (self-reported)	0.6	0.8	1.8	-0.7	-0.8	-0.7	-1.4	-0.9	-0.7
Pulse rate, automated reading	0.6	2.0	4.4	-1.2	-2.1	-2.0	-0.5	-0.3	-1.3
Leg pain on walking	0.6	0.8	1.6	0.1	1.3	0.5	1.2	1.2	0.2
Illnesses of siblings: Diabetes	0.6	0.8	1.5	-0.6	-1.0	-0.4	-1.1	-1.2	-0.6
Arm fat percentage (left)	0.6	2.6	6.7	-1.2	-2.6	-2.1	-0.9	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.9	0.2	-0.7	0.6	2.0	1.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.9	0.3	-0.6	-1.1	-2.2	-1.1	0.3
Breast Cancer	0.5	1.3	2.7	0.2	0.6	1.7	1.4	1.6	0.3
Average weekly spirits intake	0.5	0.7	2.7	0.3	-0.3	-0.3	-1.6	-1.0	0.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.5	-1.2	-0.4	0.0	0.4	-0.1	-1.2
Medication: Ramipril	0.5	0.7	1.1	-1.0	-0.6	-0.7	-0.6	-0.9	-1.0
Worrier / anxious feelings	0.5	0.9	2.4	-0.3	-0.3	-0.6	-1.5	-1.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	-0.9	-0.2	0.4	-1.2	-0.5	-1.0
Health satisfaction	0.5	0.6	1.8	-0.4	0.2	0.9	1.0	1.4	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.4	-0.3	-0.7	-1.5	0.2	-0.5	-0.3
Friendships satisfaction	0.5	0.6	1.4	0.5	-0.6	0.1	1.1	1.2	0.4
Eye problems/disorders: Cataract	0.5	0.6	1.3	1.1	0.4	0.7	-0.1	0.5	1.1
Illnesses of father: None of the above (group 1)	0.5	0.6	2.6	0.0	0.4	0.9	1.6	0.6	0.0
Wears glasses or contact lenses	0.5	0.6	1.6	-0.1	0.0	-1.0	-1.3	-1.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	-0.0	-1.0	-1.2	-1.0	-0.4	-0.0
Number of operations (self-reported)	0.5	0.7	2.8	-0.2	1.7	0.2	1.1	0.3	-0.1
Age started oral contraceptive pill	0.5	0.6	1.3	0.5	1.1	0.8	-0.4	0.9	0.5
Crohns Disease (2017)	0.4	0.8	1.4	-0.9	-0.3	-0.7	-1.2	-1.1	-1.0
Reaction Time	0.4	0.8	2.5	-0.9	-0.1	-0.1	1.6	0.7	-0.9
Schizophrenia (2014)	0.4	0.9	2.2	0.9	0.8	0.8	1.5	0.7	0.8
Chronotype (morning person)	0.4	1.0	2.5	-0.7	-1.3	-1.6	-0.1	-0.8	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	-0.4	1.0	0.0	1.3	0.3	-0.4
Supplements: Zinc	0.4	0.4	0.9	0.3	0.3	1.0	0.9	0.7	0.4
Diabetes (father)	0.4	0.5	0.9	0.3	0.5	0.9	0.9	0.8	0.3
Trunk fat percentage	0.4	1.6	4.9	-0.8	-2.2	-1.6	-0.8	-0.6	-0.9
Current tobacco smoking	0.4	0.7	1.6	-0.1	1.3	1.2	0.9	0.3	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.6	1.0	1.1	0.1	-0.0	0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	1.2	0.2	0.3	-0.2	0.4	1.2
Mouth/teeth dental problems	0.4	0.7	1.7	-0.9	-0.3	-0.5	-1.3	-0.7	-0.8
Father’s age at death	0.4	0.6	1.5	-1.2	-0.2	0.1	-0.6	-0.3	-1.2
Number of live births	0.4	0.6	1.1	1.0	0.6	0.2	1.1	0.5	1.0
Lung cancer (father)	0.4	0.4	1.8	-0.1	-1.4	-0.5	-0.6	-0.3	-0.3
Pulse wave peak to peak time	0.4	0.5	1.2	0.3	0.9	1.1	0.9	0.5	0.3
Medication: Ibuprofen	0.4	0.4	0.9	-0.7	0.3	-0.8	0.9	-0.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	1.2	0.1	0.1	-0.4	-0.3	1.2
Average weekly red wine intake	0.4	0.5	2.6	0.4	0.4	-0.1	-1.6	-0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.6	0.5	0.5	-0.2	1.3	0.6	0.4
Medication: Aspirin	0.4	0.6	1.1	-1.0	-0.9	-0.7	0.2	0.3	-1.0
Medication: Atorvastatin	0.4	0.5	1.9	-0.5	-0.1	-0.0	1.4	0.8	-0.5
Pain experienced in last month	0.4	0.7	1.4	-0.1	0.9	1.0	1.2	0.9	-0.1
Alcohol drinker status: Previous	0.4	0.5	1.8	-0.0	-0.7	-1.3	-0.6	-0.6	-0.1
Depression (Nagel 2018)	0.3	0.5	1.1	1.0	0.4	0.2	0.2	0.6	1.1
Alzheimer’s Disease (in father)	0.3	0.3	1.4	-0.2	-0.2	-0.1	-1.2	-0.6	-0.2
Ovarian Cancer	0.3	0.3	0.6	-0.7	-0.5	-0.5	-0.2	-0.7	-0.8
HbA1C	0.3	0.3	1.1	0.0	-0.5	-1.1	0.3	-0.2	0.7
Allergy or Eczema	0.3	0.7	1.8	-0.7	-0.8	-0.2	-1.4	-0.9	-0.7
Neuroticism	0.3	0.8	1.7	-0.5	-1.0	-0.7	-1.3	-0.9	-0.4
Number of treatments/medications taken	0.3	0.6	0.9	-0.8	-0.9	-0.7	0.8	0.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.7	-0.2	-0.5	-1.3	-0.4	-0.1	-0.3
Severe depression (siblings)	0.3	0.3	0.8	0.7	0.9	-0.1	0.3	-0.2	0.8
Age when periods started (menarche)	0.3	0.6	1.5	0.8	0.9	0.6	1.2	0.3	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	0.2	0.1	0.5	1.0	0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.1	-1.0	-0.9	-0.5	-1.1	-0.6	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.5	0.4	-0.1	0.1	1.2	0.9	0.5
Pulse rate	0.3	0.6	2.0	-0.1	-1.0	-1.4	0.5	0.0	-0.2
Happiness	0.3	0.3	0.9	-0.4	-0.1	0.9	0.5	0.7	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	-1.0	-0.2	-0.3	-1.3	-0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.2	-0.3	0.7	-0.0	1.1	0.3	-0.3
Tense / ‘highly strung’	0.3	0.5	1.1	-0.6	-0.7	-0.6	-0.7	-1.0	-0.6
Birth weight of first child	0.3	0.6	1.0	-0.8	-1.0	-0.7	-0.8	-0.4	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	-0.7	-0.6	-0.9	-0.8	-0.7	-0.7
Age at first live birth	0.3	0.5	1.1	0.5	0.1	-0.9	-1.0	-0.8	0.4
Angina (self-reported)	0.3	0.3	0.7	0.8	-0.3	0.3	0.2	0.8	0.8
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-0.4	-1.1	-0.1	-0.8	-0.1	-0.4
Age at last live birth	0.3	0.5	1.0	1.0	0.4	-0.2	0.7	0.2	1.0
Family relationship satisfaction	0.3	0.4	1.3	0.2	-0.4	0.4	1.2	0.9	0.2
Knee pain experienced in last month	0.3	0.5	1.4	-0.4	0.3	-0.5	-1.1	-1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.9	0.3	0.5	0.5	-0.5	-0.8
Loneliness, isolation	0.3	0.4	0.7	-0.8	-0.8	0.3	0.2	0.1	-0.8
Ever had bowel cancer screening	0.3	0.3	0.9	-0.2	0.4	0.1	-0.9	-0.8	-0.2
Qualifications: nursing, teaching	0.3	0.5	2.0	-0.4	0.5	0.4	-1.4	-0.4	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.6	0.7	0.5	-0.7	-0.0	-0.2	0.7
Osteoarthritis (self-reported)	0.3	0.3	0.6	-0.7	-0.2	0.0	0.8	0.5	-0.7
Smoking status: Current	0.3	0.5	1.3	-0.2	1.1	1.0	0.8	0.1	-0.1
Guilty feelings	0.3	0.5	0.8	-0.7	-0.7	-0.4	-0.9	-0.8	-0.6
Ever taken oral contraceptive pill	0.3	0.3	1.0	0.1	0.8	0.1	1.0	0.6	0.1
Medication: Blood pressure	0.3	0.6	1.0	1.0	0.7	0.6	0.6	0.9	1.0
Medication: Paracetamol	0.3	0.5	1.7	0.5	-1.3	-0.7	-0.3	0.5	0.4
Medication: Lisinopril	0.3	0.3	1.2	0.1	-1.1	-0.5	-0.8	0.2	0.0
Commuting to job workplace: Cycle	0.3	0.3	0.9	-0.4	1.0	0.8	-0.1	0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.1	-1.1	-0.9	-1.0	-0.8	-1.0	-1.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.2	-0.7	-0.6	-0.7	0.2	0.1
Alzheimer’s Disease (including proxy)	0.2	0.2	0.9	0.1	-0.5	-0.5	-0.9	-0.1	0.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.1	0.6	0.1	-0.6	-0.7	0.2
Fasting Glucose	0.2	0.2	1.0	0.1	-0.2	-0.3	1.0	0.5	0.2
HDL Cholesterol	0.2	0.3	0.8	0.4	0.3	0.9	0.4	0.7	0.5
Neuroticism (2016)	0.2	0.3	0.9	-0.2	-1.0	0.2	-0.7	0.3	-0.1
Ulcerative Colitis	0.2	0.3	0.9	-0.2	0.5	0.2	-0.9	-0.6	-0.2
Height	0.2	3.8	6.1	2.1	1.9	1.0	2.5	1.8	2.1
Cardiovascular Disease	0.2	0.6	1.6	-0.2	-1.0	-0.7	-1.3	-0.8	-0.2
Respiratory disease	0.2	0.4	1.3	0.2	1.0	1.1	0.2	0.4	0.2
Sensitivity / hurt feelings	0.2	0.4	1.2	0.6	0.6	1.1	-0.1	0.3	0.7
Hearing difficulty/problems: Yes	0.2	0.4	0.5	0.6	0.7	0.3	0.7	0.7	0.6
Angina	0.2	0.3	0.5	0.7	-0.4	0.3	0.2	0.7	0.7
Average weekly fortified wine intake	0.2	0.2	0.4	0.7	-0.3	0.4	0.2	-0.0	0.6
Taking other prescription medications	0.2	0.3	0.6	-0.8	-0.2	-0.2	0.7	0.2	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.4	-0.6	-0.6	-0.3	-0.4	-0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.6	0.3	0.3	0.3	0.4	-0.6
High blood pressure	0.2	0.5	0.8	0.6	0.9	0.8	0.5	0.6	0.7
High blood pressure (mother)	0.2	0.2	0.5	-0.7	-0.6	-0.0	-0.0	-0.3	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.5	0.4	0.2	-0.8	-0.5	0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.6	0.7	0.2	0.5	0.6	0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	-0.6	-0.8	-0.2	0.1	0.1	-0.6
Allergy	0.2	0.6	1.6	-0.3	-0.7	-1.3	-0.7	-0.8	-0.3
Illnesses of siblings	0.2	0.3	0.5	-0.7	-0.4	0.3	0.5	0.5	-0.7
Neuroticism score	0.2	0.5	1.0	-0.4	-0.8	-0.2	-1.0	-0.9	-0.4
Falls in the last year	0.2	0.3	1.1	-0.2	-0.4	-1.0	-0.5	-0.4	-0.2
Illnesses of mother	0.2	0.2	0.6	0.0	-0.2	0.1	0.8	0.7	-0.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.9	-0.1	-0.7	-0.9	-0.6	-0.2	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	1.3	0.7	-0.0	0.4	0.3	1.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.8	0.4	0.3	-0.4	-0.6	0.7
Mean time to correctly identify matches	0.2	0.3	0.7	-0.9	-0.2	-0.4	0.7	0.0	-0.9
Number of full sisters	0.2	0.3	0.9	-0.4	0.5	0.9	0.2	0.2	-0.4
Suffer from ‘nerves’	0.2	0.3	0.9	0.6	0.1	0.2	-0.6	-0.9	0.6
Overall health rating	0.2	0.5	2.0	-0.4	-0.4	-1.4	-0.2	-0.6	-0.4
Chest pain or discomfort	0.2	0.2	0.8	-0.3	0.5	-0.5	-0.2	-0.9	-0.3
Medication: Aspirin	0.2	0.3	0.6	-0.7	-0.6	-0.3	0.2	0.5	-0.7
Illnesses of father: Heart disease	0.2	0.2	0.7	0.3	-0.9	-0.5	-0.3	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.8	-0.2	-0.3	1.1	0.3	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	0.4	0.4	0.2	0.7	0.6	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.2	0.8	0.8	-0.1	0.3	0.2
Cholesterol lowering medication	0.2	0.4	1.0	-0.4	-1.0	-0.3	-0.8	-0.3	-0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.5	-0.5	0.3	0.1	0.5	0.5
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.1	-0.7	-0.3	-1.0	-0.4	-0.1
Schizophrenia (2018)	0.1	0.1	0.3	-0.4	-0.4	0.1	0.5	-0.3	-0.4
Worry (Nagel 2018)	0.1	0.2	0.6	0.1	-0.4	-0.3	-0.8	-0.5	0.1
Major Depression (MDD)	0.1	0.1	0.4	0.1	0.2	0.6	-0.1	0.3	-0.0
Age at First Birth	0.1	0.2	0.5	0.7	0.3	-0.5	-0.3	-0.2	0.5
Triglycerides	0.1	0.2	0.6	0.4	-0.1	-0.1	0.8	0.6	0.3
Blood Eosinophil Count	0.1	0.6	1.6	-0.8	-0.0	1.3	0.4	0.4	-0.9
Blood Platelet Count	0.1	1.6	5.2	-0.8	-2.3	-0.1	-1.7	-0.4	-0.8
Blood Red Count	0.1	1.2	3.5	1.9	-0.3	0.4	-0.5	0.5	1.7
Heel T-Score	0.1	0.5	1.9	-0.1	0.1	0.2	1.4	1.1	-0.1
Lung FEV1/FVC ratio	0.1	0.3	0.7	0.9	0.0	-0.2	0.0	0.6	0.8
Hair Pigment	0.1	1.7	2.9	-0.8	-1.6	-1.4	-1.7	-1.2	-0.8
Tanning	0.1	1.8	2.7	1.4	1.2	1.2	1.6	1.2	1.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.5	0.7	0.3	0.2	0.1	0.6
Fed-up feelings	0.1	0.3	0.7	0.3	-0.2	0.8	0.4	0.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.3	0.0	0.1	0.6	0.4	0.3
Relative age voice broke	0.1	0.1	0.3	0.6	0.3	-0.0	-0.3	0.2	0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.7	0.2	-0.3	0.9	0.1	0.4	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	0.0	-0.3	0.5	-0.6	0.0	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.0	-0.6	0.0	-0.4	-0.3	0.1
Supplements: Glucosamine	0.1	0.2	0.8	0.3	-0.0	-0.0	-0.9	-0.2	0.2
Had other major operations	0.1	0.1	0.5	-0.0	0.4	-0.5	0.7	-0.0	-0.0
Forced vital capacity (FVC)	0.1	0.4	0.9	-0.2	-0.6	-0.8	-0.9	-0.8	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.7	-0.8	-0.3	-0.5	-0.3	-0.7
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.1	-0.6	-0.1	0.2	0.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	-0.1	-0.8	-0.7	-0.8	-0.6	-0.2
Asthma	0.1	0.1	0.3	-0.6	0.1	0.1	0.4	0.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	1.1	0.2	-0.2	0.0	0.1	1.0
Breastfed as a baby	0.1	0.1	0.4	-0.2	-0.1	-0.3	-0.6	-0.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.2	-0.0	-0.1	-0.7	-0.6	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.5	-0.3	-0.8	0.2	-0.1	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.4	-0.5	0.0	0.1	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.4	0.6	-0.0	0.5	0.2	0.4
Blood clot in the leg (DVT)	0.1	0.2	0.3	0.0	0.6	0.5	0.5	0.3	0.0
Medication: Paracetamol	0.1	0.1	0.6	0.1	-0.8	-0.1	-0.1	0.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.9	0.0	0.2	-0.3	-0.2	-0.9	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.5	0.0	0.5	0.7	-0.0	0.0	0.0
Medication: Blood pressure	0.1	0.2	0.3	-0.5	-0.5	0.1	-0.5	-0.3	-0.5
Medication: Allopurinol	0.1	0.1	0.3	-0.1	-0.4	-0.2	-0.5	-0.1	-0.1
Comparative height size at age 10	0.1	0.8	1.2	1.1	0.7	0.9	0.6	1.0	1.1
Mood swings	0.1	0.2	0.8	0.2	-0.1	0.9	0.3	0.3	0.3
Mineral and other dietary supplements	0.1	0.1	0.3	-0.1	-0.0	0.5	-0.5	-0.1	-0.1
Asthma (self-reported)	0.1	0.1	0.4	-0.6	-0.2	0.0	0.2	-0.1	-0.6
Miserableness	0.1	0.3	0.6	-0.2	-0.5	-0.8	-0.2	-0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.1	-0.0	0.1	0.5	0.5	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.3	0.2	0.3	0.4	0.5	-0.3
Risk taking	0.1	0.1	0.2	0.4	0.5	-0.1	0.2	0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.1	0.3	0.4	0.3	0.2	-0.1
Rheumatoid Arthritis	0.0	0.0	0.1	0.2	-0.1	-0.1	0.0	0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.0	0.2	0.3
Blood White Count	0.0	0.4	1.0	-0.4	-1.0	0.7	-0.3	0.6	-0.3
Waist Hip Ratio (WHR)	0.0	0.1	0.5	0.1	-0.7	-0.1	0.1	-0.2	0.1
Relative age of first facial hair	0.0	0.1	0.5	0.1	0.3	0.7	0.0	-0.2	0.1
Diabetes (mother)	0.0	0.1	0.1	0.2	-0.2	-0.2	0.4	0.2	0.1
Maternal smoking around birth	0.0	0.1	0.3	0.0	0.1	0.3	0.1	0.6	0.1
Sitting height	0.0	0.2	0.6	-0.0	0.8	0.1	0.6	-0.0	-0.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.2	0.0	0.2	-0.0	-0.2	-0.2
Prospective memory result	0.0	0.0	0.1	-0.1	-0.2	-0.0	0.4	0.2	-0.1
Standing height	0.0	0.3	1.0	-0.0	0.1	-0.8	-0.2	-1.0	-0.1
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.1	0.5	0.1	-0.1	-0.3	0.1
Pulse wave reflection index	0.0	0.0	0.1	0.3	0.0	0.2	0.1	0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.3	0.0	0.1	0.1	0.5	-0.2	0.1
Comparative body size at age 10	0.0	0.1	0.2	0.3	-0.2	-0.4	-0.4	0.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.0	0.0	-0.2	0.1	0.1	-0.1
Hypertension (Self-reported)	0.0	0.1	0.2	0.2	0.4	0.4	0.2	0.2	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.0	-0.1	-0.3
Medication for cholesterol	0.0	0.0	0.1	-0.0	0.0	-0.2	0.4	-0.0	-0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	-0.1	0.4	0.3	0.0	0.1	-0.1

Hub : Genes

LOC646999

Models

Trait associations