Hub : Genes

LOC729991

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0204	0.0087	4.7e-03	0.003	0.004	0.005	0.005	0.005	3.6e-02	1.2e-02	6.7e-03	0.0056	9.8e-03
2	TCGA	Breast Invasive Carcinoma	0.0146	0.0079	9.8e-03	0.003	0.001	0.000	NA	0.002	7.6e-02	1.5e-01	3.5e-01	NA	1.1e-01
3	TCGA	Brain Lower Grade Glioma	0.1441	0.0435	3.7e-13	0.114	0.107	0.116	NA	0.116	6.8e-13	3.8e-12	4.1e-13	NA	4.3e-13
4	TCGA	Lung Squamous Cell Carcinoma	0.0738	0.0340	1.7e-03	0.006	0.021	0.003	NA	0.004	5.9e-02	1.5e-03	1.4e-01	NA	1.2e-01
5	TCGA	Soft Tissue Sarcoma	0.0590	0.0300	6.5e-03	-0.001	0.019	-0.004	NA	-0.005	4.1e-01	2.6e-02	7.6e-01	NA	9.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	5.7	0.7	2.4	0.7	0.5	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.6	2.2	0.8	1.5	0.4	-0.2	-0.5
Depressed Affect (Nagel 2018)	1.0	2.1	5.9	-0.6	-1.0	0.7	1.6	2.4
Depression (Nagel 2018)	0.5	0.8	2.7	-0.7	0.1	0.3	0.8	1.6
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.9	2.2	-0.1	-1.6	1.8	-1.0
Neuroticism (Nagel 2018)	1.0	2.3	7.0	-0.7	-0.3	0.8	1.7	2.6
Schizophrenia (2018)	0.1	0.2	0.7	0.5	-0.0	0.0	-0.9	-0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	-1.7	-0.7	0.4	-1.5	0.5
Worry (Nagel 2018)	0.9	1.9	4.2	-0.0	1.0	1.3	1.5	2.1
Alzheimer’s Disease (in mother)	0.9	1.0	1.7	0.2	-1.3	-1.1	-0.6	-1.3
Alzheimer’s Disease (in father)	1.1	1.2	4.0	-0.4	-1.1	0.4	0.6	2.0
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	-0.7	-1.5	-0.1	0.1	0.9
Crohns Disease (2017)	0.1	0.3	0.6	0.6	-0.8	-0.1	0.1	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	-0.8	-0.0	0.9	-0.6	0.7
Ulcerative Colitis (UC)	1.3	2.4	4.5	-2.1	1.1	1.6	-0.9	1.7
Major Depression (MDD)	0.2	0.2	0.9	1.0	0.0	0.0	0.0	0.0
Reaction Time	0.5	1.0	1.6	1.0	0.7	-1.3	0.9	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.3	1.0	-0.8	-1.2	1.0	-0.4
Breast Cancer	1.9	4.5	12.7	2.0	0.3	-1.3	-2.0	-3.6
Ovarian Cancer	0.5	0.6	1.2	1.1	-0.7	-0.4	0.8	0.7
Prostate Cancer	0.2	0.3	1.1	0.0	-0.3	0.7	-0.3	1.0
Age at First Birth	1.2	1.7	3.7	-0.6	0.1	-0.9	-1.9	-1.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	-0.1	-0.4	0.6	-0.6
Coronary Artery Disease (CAD)	1.4	1.6	3.6	1.2	1.1	-0.6	-1.2	-1.9
Crohns Disease (2012)	0.1	0.2	0.9	0.1	-1.0	-0.2	0.3	0.0
Mean Putamen Volume	0.3	0.4	0.7	-0.8	0.4	0.5	-0.3	0.8
Fasting Glucose	0.4	0.5	1.6	-0.0	1.3	0.7	-0.3	-0.2
HbA1C	0.5	0.6	1.2	-0.8	0.6	1.1	0.1	0.9
HDL Cholesterol	0.5	0.8	2.3	-1.5	1.0	0.4	-0.7	0.2
LDL Cholesterol	4.7	7.4	14.1	3.1	3.8	0.0	3.4	1.5
Lupus	0.6	0.9	2.0	1.3	-0.2	-1.4	-0.3	-1.0
Neuroticism (2016)	0.3	0.5	1.6	-0.1	-1.3	-0.7	0.5	0.0
Primary Biliary Cirrhosis	0.3	0.4	1.2	-1.1	0.3	-0.2	0.6	0.7
Rheumatoid Arthritis	1.0	1.4	2.8	1.7	-0.9	-1.0	-0.8	-1.3
Schizophrenia (2014)	0.2	0.4	1.6	1.3	0.2	-0.0	-0.6	-0.3
Triglycerides	3.2	5.2	14.7	1.8	3.8	0.5	2.6	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	0.7	-1.1	-0.8	-0.5	-1.3
Ulcerative Colitis	0.7	1.0	2.1	-1.0	0.1	1.0	-1.0	1.5
Blood Eosinophil Count	0.5	3.8	8.8	-1.6	0.1	2.8	0.3	3.0
Blood Platelet Count	0.4	4.6	13.8	1.5	-3.7	-0.6	-2.4	-0.8
Blood Red Count	0.5	4.6	9.9	-3.1	-2.3	0.6	-2.6	-0.9
Blood White Count	0.3	2.5	4.7	-1.7	-2.2	1.0	-2.0	0.2
Heel T-Score	0.3	2.7	9.8	0.8	-3.1	-1.5	0.7	-0.2
BMI	0.8	4.9	13.2	-0.8	-1.0	0.7	3.6	3.0
Height	0.4	8.5	31.4	-1.2	5.6	1.8	2.4	0.9
Waist Hip Ratio (WHR)	0.4	2.0	8.5	-0.2	-2.9	-0.2	-0.8	0.9
Systolic Blood Pressure	0.5	2.6	5.8	0.9	-2.4	-0.6	-1.9	-1.6
Smoking Status	1.2	2.9	4.4	1.9	-2.1	-2.0	0.0	-1.4
Allergy or Eczema	2.0	5.3	10.6	-1.9	3.2	2.3	1.9	1.9
Cardiovascular Disease	0.2	0.6	1.2	0.0	-1.1	0.7	-0.3	1.1
Hypothyroidism (self reported)	1.0	2.3	6.1	1.6	-2.5	-1.6	0.4	-0.2
Respiratory disease	1.7	3.8	9.2	-0.2	0.5	1.3	2.8	3.0
Type 2 Diabetes (T2D) (2018)	0.5	0.8	3.8	-0.2	-1.9	-0.2	0.5	0.3
Lung FEV1/FVC ratio	0.4	1.9	7.8	-2.8	-0.4	0.6	0.1	1.2
Lung FVC	0.0	0.2	0.7	0.7	0.3	0.0	-0.8	-0.2
Neuroticism	1.0	2.3	5.0	-1.0	0.7	0.9	2.1	2.2
Chronotype (morning person)	0.6	1.4	3.9	-1.2	0.9	0.9	-2.0	-0.5
Hair Pigment	0.0	0.9	2.6	-1.0	-0.9	0.1	-1.6	-0.5
Tanning	0.0	0.3	0.8	0.8	0.1	0.2	0.3	0.9
Hand grip strength (left)	0.4	0.9	2.6	0.5	0.4	-0.8	-1.6	-1.0
Number of treatments/medications taken	1.5	2.7	6.1	-1.2	-2.5	0.1	0.8	2.2
Average weekly spirits intake	1.1	1.3	3.9	-0.9	-0.4	-0.1	1.3	2.0
Sensitivity / hurt feelings	0.3	0.5	1.2	-0.9	-1.1	0.2	-0.6	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.5	0.4	0.1	-1.6	-0.2	-0.6
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.1	-0.8	-0.4	1.1	-0.0
Relative age of first facial hair	0.8	1.7	2.9	1.1	-1.7	-0.9	-1.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.6	-1.3	-0.3	0.6	0.2	1.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.1	-1.5	-1.5	-0.6	-0.9	0.0
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	0.8	-0.7	-1.0	-1.3	-1.2
Systolic blood pressure, automated reading	0.3	0.9	2.2	0.7	-1.5	-1.0	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	8.8	0.4	-3.0	-2.2	-0.1	-0.1
Angina	0.7	0.9	3.0	-0.8	-0.6	0.5	0.5	1.7
Medication for hormone replacement therapy	0.3	0.3	1.1	0.4	-0.1	-0.6	1.0	-0.1
Vitamin and mineral supplements	0.4	0.6	1.7	-0.7	0.6	-0.1	-1.3	-0.6
Supplements: Zinc	2.8	3.0	7.4	-0.2	2.3	0.9	2.7	1.3
Medication: Co-codamol	0.8	0.9	3.6	0.7	-1.9	-0.4	-0.3	-0.1
Medication: Metformin	0.4	0.6	1.2	-0.1	-0.5	0.4	1.1	1.1
Diabetes (father)	0.6	0.8	1.5	-1.2	-0.8	0.1	1.2	0.5
Diabetes (mother)	0.9	1.2	2.9	-0.6	-1.7	0.4	0.4	1.5
Severe depression (siblings)	0.4	0.5	1.2	-0.3	0.4	0.2	1.1	1.0
Pack years adult smoking proportion	1.2	1.9	3.4	-1.1	0.5	1.6	1.9	1.3
Impedance of leg (right)	0.3	1.6	3.5	0.6	-1.9	-1.4	-1.4	-0.5
Leg fat-free mass (left)	0.7	3.6	9.7	-0.2	2.0	1.4	3.1	1.5
Trunk fat percentage	0.8	3.1	12.2	0.2	0.5	0.6	3.5	1.7
Hand grip strength (right)	0.6	1.6	3.4	0.9	-0.3	-0.9	-1.9	-1.6
Townsend deprivation index at recruitment	0.5	0.7	1.1	-1.1	0.7	0.9	0.9	0.3
Current tobacco smoking	1.1	1.8	6.4	1.0	-2.5	-1.1	-0.4	-0.1
Average weekly fortified wine intake	0.4	0.5	1.9	0.2	-0.2	0.0	-1.4	-0.6
Maternal smoking around birth	2.7	3.9	13.8	2.1	-3.7	-0.8	-0.0	0.5
Fed-up feelings	0.4	0.8	1.8	-0.7	-1.2	0.1	0.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	-0.4	-0.4	0.3	0.1	0.9
Relative age voice broke	1.5	2.3	4.0	2.0	-1.4	-1.3	-1.3	-1.5
Taking other prescription medications	1.1	1.8	3.6	-0.9	-1.8	-0.1	1.0	1.9
Age when periods started (menarche)	0.3	0.7	2.0	-0.5	1.4	1.0	-0.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.6	1.9	-0.0	-0.9	-0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.9	-0.5	0.2	1.0	0.8	1.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.1	0.8	-0.3	0.1	0.2	-1.0
Qualifications: CSEs or equivalent	2.0	2.6	6.5	2.5	-2.2	-0.7	1.1	-0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.8	0.2	-0.0	0.5	0.1
High blood pressure	0.8	2.3	3.7	-1.7	-1.9	1.0	-0.0	1.9
Hayfever, allergic rhinitis or eczema	1.2	2.6	5.2	-1.9	2.3	1.4	1.0	1.1
Multivitamins +/- minerals	0.2	0.3	0.8	0.1	-0.9	0.5	0.4	0.6
Stomach or abdominal pain in last month	1.2	1.4	4.8	0.8	-2.2	-1.0	-0.8	0.3
Supplements: Glucosamine	0.3	0.4	0.8	-0.7	0.9	-0.2	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.0	-0.8	0.4	1.1	0.7	1.7
Medication: Atenolol	0.5	0.6	1.1	-1.1	-0.5	0.6	-0.5	1.1
Medication: Levothyroxine sodium	0.4	0.7	2.9	0.8	-1.7	-0.3	-0.1	0.1
Sitting height	0.2	1.7	4.9	1.4	1.1	-0.4	2.2	0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	-1.0	-0.3	0.3	0.9	1.6
High blood pressure (mother)	1.3	1.9	6.9	-0.4	-2.6	-1.3	0.4	0.5
Body mass index (BMI)	0.6	2.4	6.4	-0.7	-1.2	0.4	2.5	1.9
Impedance of leg (left)	0.4	1.9	3.6	0.6	-1.9	-1.4	-1.8	-0.6
Leg predicted mass (left)	0.7	3.6	9.4	-0.2	2.1	1.4	3.1	1.5
Trunk fat mass	0.9	4.0	14.4	-0.1	0.8	1.0	3.8	1.9
Waist circumference	1.0	3.5	8.6	-1.1	-1.0	1.0	2.9	2.4
Number of incorrect matches in round	0.3	0.6	1.3	-0.1	0.1	-0.6	-1.1	-1.1
Past tobacco smoking	0.4	0.8	1.6	-0.8	0.9	1.2	-0.8	0.6
Alcohol usually taken with meals	1.2	1.9	5.0	0.5	-0.4	-1.0	-1.7	-2.2
Nervous feelings	0.9	1.7	3.4	-1.2	1.1	1.1	1.0	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.6	0.2	1.2	-0.0	0.2	-0.0
Hearing difficulty/problems with background noise	0.6	1.0	2.2	-1.5	-0.1	1.4	-0.2	0.7
Hair/balding pattern: Pattern 2	1.2	1.5	4.1	-1.5	-0.6	0.9	0.2	2.0
Had menopause	0.9	1.1	2.4	-1.2	-1.2	-0.5	-1.6	-0.4
Had other major operations	1.5	1.9	5.5	-0.7	0.2	1.2	2.4	1.4
Forced vital capacity (FVC)	0.2	0.7	2.4	0.5	1.6	0.2	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.9	-0.6	-0.4	0.8	0.2
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	5.0	-0.9	1.1	2.2	1.5	2.2
Qualifications: None of the above	0.6	1.3	5.2	-0.5	-2.3	0.0	0.5	0.9
Financial difficulties in last 2 years	0.5	0.7	1.7	0.6	-1.1	-0.5	1.3	0.3
Mouth/teeth dental problems	2.4	3.6	8.2	1.7	0.8	-1.3	-2.1	-2.9
Heart attack	0.7	0.9	2.6	-1.2	0.2	0.7	0.3	1.6
Allergy	1.9	4.3	6.7	1.8	-2.6	-1.9	-2.1	-1.8
Pain all over the body in last month	0.7	0.8	1.2	0.9	-1.1	-0.1	1.1	1.0
Diabetes (self-reported)	0.5	0.7	2.3	-0.7	-1.5	-0.2	0.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.2	0.2	-1.3	-0.5	-0.8
Medication: Ramipril	2.2	2.8	10.5	0.0	-3.2	-1.1	-1.5	-0.2
Medication: Simvastatin	0.4	0.5	1.9	-0.1	1.4	0.7	0.0	0.5
Fluid intelligence score	0.1	0.2	0.5	0.5	0.7	-0.4	0.5	-0.2
Illnesses of siblings	0.9	1.2	2.5	1.1	1.2	-0.1	-1.0	-1.6
Neuroticism score	0.5	1.0	2.5	-0.4	0.3	0.3	1.5	1.6
Weight	0.8	3.7	12.2	-0.6	0.8	1.1	3.5	2.0
Impedance of arm (right)	0.6	2.9	8.1	2.0	2.8	-0.2	0.7	-1.4
Arm fat percentage (right)	0.5	2.0	8.2	0.1	-0.1	0.4	2.9	1.2
Trunk fat-free mass	0.3	1.8	3.9	-0.9	1.2	1.0	2.0	1.4
Hip circumference	0.7	2.9	10.4	-0.4	0.7	0.6	3.2	1.7
Time employed in main current job	1.1	1.3	3.0	-1.1	-0.2	0.9	1.2	1.7
Alcohol intake versus 10 years previously	1.1	1.7	5.5	-0.2	-2.4	0.5	0.5	1.6
Father’s age at death	0.3	0.4	0.9	0.0	1.0	-0.3	0.6	-0.8
Worrier / anxious feelings	0.3	0.5	0.9	0.1	-0.8	-0.4	0.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.5	-0.0	-1.4	-0.5	1.9	1.1
Falls in the last year	1.4	1.8	5.2	-0.2	-0.1	0.3	2.3	1.9
Hair/balding pattern: Pattern 3	0.4	0.5	1.4	0.6	0.7	-0.6	0.3	-1.2
Number of live births	0.7	1.0	3.5	0.4	-1.9	-0.4	0.7	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.8	-0.1	1.3	0.4	0.4	0.8
Pulse rate	0.5	0.8	2.0	-0.7	-1.0	-0.5	-1.4	0.3
Happiness	1.2	1.4	3.8	-1.1	1.9	0.6	1.1	0.8
Noisy workplace	0.1	0.1	0.3	0.6	0.4	0.1	-0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.3	0.7	2.1	-0.5	-0.6	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	0.7	0.9	1.0	1.0	0.7
Mouth/teeth dental problems: Dentures	1.0	1.6	3.1	-1.2	-1.1	1.4	0.7	1.8
Asthma	1.9	3.8	6.9	-0.6	1.6	1.7	2.6	2.5
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.8	0.7	-1.4	-1.0	2.4	1.1
Medication: Cholesterol lowering	0.8	1.2	2.2	0.5	1.5	0.7	1.0	1.5
Depression (self-reported)	2.0	2.4	6.6	-1.2	1.0	1.1	1.5	2.6
Medication: Lansoprazole	1.2	1.4	3.8	-2.0	-1.3	0.5	-0.3	1.1
Prospective memory result	0.3	0.4	1.0	-1.0	-0.3	0.6	-0.6	-0.2
Lung cancer (father)	2.1	2.4	4.8	-2.2	0.2	1.8	-0.1	2.0
Illnesses of mother	1.5	1.8	4.0	2.0	1.2	-0.9	-0.5	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.9	-0.2	2.2	1.3	0.1	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.1	-0.7	0.4	-0.6	0.3
Impedance of arm (left)	0.6	3.0	10.3	1.7	3.2	0.2	0.6	-1.1
Arm fat mass (right)	0.7	2.8	10.4	-0.2	-0.1	0.7	3.2	1.7
Trunk predicted mass	0.3	1.7	4.1	-0.8	1.1	0.9	2.0	1.3
Standing height	0.5	5.1	17.0	-0.1	4.1	1.6	2.4	0.7
Length of working week for main job	1.4	1.6	5.6	0.8	0.0	-0.1	2.4	1.3
Exposure to tobacco smoke at home	0.7	0.8	2.5	0.8	-1.6	-0.7	0.4	0.3
Breastfed as a baby	2.0	2.4	7.0	0.9	0.2	-1.1	-1.8	-2.6
Tense / ‘highly strung’	1.3	2.2	3.6	-1.8	1.9	1.4	0.2	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.1	-0.5	-0.1	0.9	1.9	2.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	0.6	-0.7	-0.1	1.0	0.7
Birth weight of first child	1.1	2.0	4.4	-1.8	2.1	0.5	0.4	1.3
Peak expiratory flow (PEF)	1.7	4.0	7.0	-1.5	2.7	1.7	1.7	2.2
Pulse wave reflection index	0.1	0.1	0.3	0.0	-0.3	0.6	-0.3	-0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-0.7	-0.5	0.7	-0.8	1.0
Loud music exposure frequency	0.2	0.2	0.6	0.1	0.5	-0.2	-0.8	-0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	0.3	1.0	-0.5	-1.4	-0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.1	-0.5	-1.4	-0.2	1.4	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.2	-0.6	-0.3	0.1	-0.2
Medication: Paracetamol	2.3	3.8	9.4	-1.3	-1.7	0.8	2.0	3.1
Headache pain in last month	3.0	5.2	14.5	-0.2	-0.6	1.2	3.8	3.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	0.5	0.1	-0.5	-0.1	-1.1
Glaucoma (self-reported)	0.5	0.6	1.7	-1.3	0.3	0.2	-0.5	-1.0
Gout (self-reported)	0.4	0.5	1.0	0.1	-1.0	-0.7	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.8	1.2	-2.2	-1.2	-0.2	-0.3
Medication: Amlodipine	1.0	1.4	1.9	1.4	-1.4	-0.9	-1.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	0.3	0.4	0.1	1.2	0.9
Birth weight	0.8	1.7	4.0	-0.2	1.3	-0.5	-1.7	-2.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.2	-0.1	-0.5	1.0	0.7	1.5
High blood pressure (siblings)	0.5	0.7	2.1	-1.4	-0.4	0.2	0.1	1.1
Forced vital capacity (FVC), Best measure	0.3	1.2	4.5	0.6	2.1	0.8	0.6	0.6
Body fat percentage	0.5	2.1	8.0	0.1	-0.7	0.2	2.8	1.5
Leg fat percentage (right)	0.8	2.8	7.1	-0.1	-2.7	-0.8	2.0	1.4
Arm fat-free mass (right)	0.4	2.3	4.4	-1.2	0.3	1.0	2.1	2.1
Exposure to tobacco smoke outside home	0.5	0.7	1.5	1.1	0.6	0.2	1.2	0.3
Comparative body size at age 10	1.2	3.4	6.2	2.4	0.8	-1.7	1.2	-2.5
Number of full brothers	1.6	2.1	3.2	1.6	-1.6	-1.4	0.3	-1.8
Worry too long after embarrassment	0.6	1.0	2.3	0.9	-0.5	-1.5	0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.4	-0.3	1.5	0.9	0.1	-0.1
Wheeze or whistling in the chest in last year	1.0	1.9	4.5	-0.7	-0.4	1.0	1.8	2.1
Number of children fathered	5.4	6.1	10.4	-1.7	1.3	2.7	2.8	3.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.8	-0.3	-0.9	-0.6	-1.7	-0.4
Age at first live birth	1.2	2.1	4.1	-0.7	2.0	-0.3	-1.8	-1.6
Pulse wave peak to peak time	0.3	0.3	0.6	0.0	0.8	-0.5	0.7	-0.4
Health satisfaction	0.6	0.8	1.8	-0.8	-0.6	0.6	1.4	0.8
Shortness of breath walking on level ground	0.9	1.1	2.3	-0.7	-1.5	0.2	1.0	1.2
Qualifications: College or University degree	0.6	1.9	4.4	0.8	2.1	-0.5	-0.5	-2.1
Eye problems/disorders: None of the above	1.2	1.4	3.3	1.8	1.6	0.9	0.0	-0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	-0.2	-1.4	-0.5	-1.1	-0.3
Emphysema/chronic bronchitis	0.4	0.4	1.6	1.3	-0.3	0.2	0.2	-0.5
Medication for pain relief, constipation, heartburn	2.4	4.0	9.9	1.4	1.8	-0.6	-2.1	-3.1
Neck or shoulder pain in last month	0.5	0.7	2.0	-0.5	-1.0	0.0	-0.3	1.4
Medication: Blood pressure	0.6	1.1	1.5	-1.2	-1.2	1.0	-0.5	1.1
Angina (self-reported)	0.7	0.9	2.9	-0.7	-0.8	0.5	0.5	1.7
Migraine (self-reported)	3.2	4.0	10.7	-0.8	0.1	1.7	2.3	3.3
Medication: Ibuprofen	1.4	1.6	3.0	0.2	-1.7	-0.3	1.7	1.5
Medication: Allopurinol	0.9	1.1	2.1	1.1	-1.5	-1.3	-0.4	-0.7
Medication: Omeprazole	1.2	1.4	2.7	-1.3	-0.2	0.3	1.6	1.6
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.4	0.6	0.4	0.2	0.7
Mean time to correctly identify matches	0.3	0.5	0.8	0.6	0.7	-0.6	0.9	-0.7
Heart disease (mother)	2.1	2.6	4.2	-1.6	2.0	2.0	1.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.1	-1.8	0.7	0.6	-0.0	-0.1
Whole body fat mass	0.7	3.0	11.2	-0.2	0.0	0.7	3.3	1.8
Leg fat mass (right)	0.7	2.7	8.4	-0.4	-1.2	0.1	2.9	1.8
Arm predicted mass (right)	0.4	2.0	4.1	-1.2	0.2	1.0	1.9	2.0
Pulse rate, automated reading	0.0	0.1	0.3	-0.5	-0.6	-0.3	0.1	0.0
Alcohol intake frequency.	0.5	1.1	2.2	0.3	0.3	1.2	1.5	1.3
Comparative height size at age 10	0.7	3.6	14.0	-0.6	3.7	1.4	1.3	0.2
Number of full sisters	0.1	0.1	0.6	-0.0	-0.1	-0.1	0.0	0.8
Suffer from ‘nerves’	1.7	2.7	6.5	1.1	1.9	1.0	2.5	1.0
Overall health rating	1.6	3.5	8.1	-0.7	-1.4	0.9	2.5	2.9
Chest pain or discomfort	1.9	2.8	11.4	0.1	-3.4	-1.6	0.2	0.1
Had major operations	3.8	4.5	8.9	-3.0	2.4	2.6	-0.6	0.8
Age at last live birth	1.1	1.5	2.8	-1.3	1.6	0.2	-1.7	-0.8
Family relationship satisfaction	0.6	0.7	1.0	-0.9	-0.8	-0.6	-1.0	-0.7
Leg pain on walking	0.6	0.8	2.0	-1.4	-1.3	-0.0	-0.4	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	1.2	-0.4	-0.8	0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.1	0.6	-0.1	0.3	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	1.2	-0.7	-0.9	0.1	-1.2
Medication: Aspirin	0.7	1.0	2.4	-1.5	-0.4	0.7	-1.1	0.8
Supplements: Vitamin C	2.1	2.5	5.2	-1.3	0.8	1.3	1.9	2.3
Knee pain experienced in last month	0.6	0.9	2.1	-1.5	-0.1	1.1	0.1	1.0
Hypertension (Self-reported)	0.8	2.3	4.6	-1.5	-2.2	0.9	0.1	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.9	-1.7	-1.0	0.9	0.3	1.2
Illnesses of father: Heart disease	2.4	3.3	11.0	-0.1	3.3	1.2	1.9	0.7
Illnesses of siblings: Diabetes	1.6	2.0	5.7	-1.4	-2.4	-0.9	0.6	1.0
Smoking status: Previous	0.1	0.1	0.6	-0.2	-0.2	-0.1	0.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	4.7	-1.8	2.2	2.0	1.3	2.1
Whole body fat-free mass	0.5	2.6	6.2	-0.7	1.5	1.2	2.5	1.6
Leg fat-free mass (right)	0.7	3.5	7.8	-0.3	2.4	1.5	2.8	1.3
Arm fat percentage (left)	0.6	2.3	8.8	0.0	0.2	0.6	3.0	1.5
Average weekly red wine intake	1.5	2.2	5.4	0.9	-0.1	-1.1	-1.8	-2.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.7	0.2	1.0	-0.7	-1.3	-1.3
Mood swings	0.2	0.3	1.0	0.1	-0.2	-0.4	0.4	1.0
Loneliness, isolation	1.6	2.1	4.9	-1.5	-0.1	1.9	0.2	2.2
Long-standing illness, disability or infirmity	4.0	6.2	11.5	-3.1	0.1	2.3	2.0	3.4
Ever had bowel cancer screening	0.6	0.7	1.7	1.1	-0.2	-0.6	1.3	-0.0
Diabetes diagnosed by doctor	0.9	1.5	5.2	-0.9	-2.3	-0.5	0.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.5	-0.3	-2.1	-0.9	-1.2	-0.4
Friendships satisfaction	0.7	0.8	1.8	-0.0	-1.3	-1.3	0.8	-0.1
Qualifications: nursing, teaching	1.1	1.7	6.1	-0.9	2.5	1.3	-0.1	0.2
Commuting to job workplace: Walk	0.7	0.7	2.1	-1.0	0.3	0.4	-1.4	0.6
Eye problems/disorders: Cataract	0.7	0.8	1.5	-1.2	-0.6	-0.8	-1.2	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.2	0.9	-0.3	-0.1	1.5	1.1
Medication for cholesterol	1.0	1.5	4.6	2.2	0.8	-0.7	0.9	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.1	-1.2	0.0	-0.8	0.1
Back pain experienced in last month	0.6	0.9	3.6	-0.2	-0.7	0.0	0.6	1.9
Mineral and other dietary supplements	0.9	1.2	2.5	-1.6	0.5	1.0	0.0	1.5
Breast cancer (self-reported)	0.7	0.8	1.3	0.9	1.2	0.9	1.1	0.0
Asthma (self-reported)	2.0	3.9	7.6	-0.6	1.2	1.6	2.7	2.8
Osteoporosis (self-reported)	0.5	0.7	1.4	0.5	-0.8	-0.7	-1.2	-0.8
Osteoarthritis (self-reported)	2.3	2.9	7.1	-2.7	0.3	1.3	0.3	2.4
Medication: Aspirin	1.0	1.3	3.2	-1.8	-0.9	0.8	-0.9	1.2
Medication: Gliclazide	1.6	1.8	6.4	0.7	-2.5	-1.3	-0.4	-0.4
Illnesses of father: None of the above (group 1)	2.4	2.9	5.2	1.0	-1.7	-1.6	-2.3	-1.7
Smoking status: Current	1.7	2.7	7.7	1.5	-2.8	-1.7	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.9	-0.5	0.7	0.9	-2.0	-0.4
Whole body water mass	0.4	2.6	5.9	-0.8	1.6	1.2	2.4	1.5
Leg predicted mass (right)	0.6	3.4	7.6	-0.3	2.4	1.5	2.8	1.3
Arm fat mass (left)	0.8	3.2	11.8	-0.3	0.3	0.8	3.4	1.9
Number of self-reported non-cancer illnesses	3.3	5.7	15.2	-2.6	-0.9	1.8	1.7	3.9
Average weekly champagne plus white wine intake	0.5	0.7	1.3	0.9	0.1	-1.0	-0.8	-1.1
Miserableness	0.9	1.5	3.3	-0.3	-1.0	0.2	1.8	1.8
Guilty feelings	0.2	0.3	1.0	-0.4	-1.0	-0.3	0.2	0.3
Wears glasses or contact lenses	0.1	0.2	0.3	-0.2	-0.5	-0.1	0.3	0.6
Ever taken oral contraceptive pill	0.7	0.8	2.0	1.0	-1.4	-0.9	0.3	0.1
Hearing aid user	1.1	1.3	2.3	1.3	-1.2	-1.5	0.9	-0.1
Mother’s age at death	0.7	0.9	2.5	-1.2	1.6	0.5	-0.3	-0.6
Financial situation satisfaction	0.3	0.4	0.6	0.4	0.8	0.3	0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.4	-0.6	0.8	0.8	1.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	0.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	-1.2	-0.0	0.0	0.0	-0.7
Medication: Blood pressure	0.9	1.8	4.2	-2.1	-1.7	0.6	-0.8	0.9
Pain type(s) experienced in last month: Hip pain	1.9	2.4	7.2	-0.9	-2.7	-2.0	-0.3	-0.0
Supplements: Fish oil (including cod liver oil)	2.0	2.6	4.0	1.7	-1.5	-1.7	-1.0	-2.0
High cholesterol (Self-reported)	1.1	1.9	4.6	0.2	2.1	1.0	1.0	1.8
Medication: Bendroflumethiazide	2.1	3.1	6.9	-2.4	0.3	1.4	1.0	2.6
Medication: Paracetamol	1.8	2.8	6.9	-1.6	-1.3	0.9	1.4	2.6
Medication: Lisinopril	0.6	0.7	1.6	-1.0	0.2	1.2	0.5	0.9
Medication: Atorvastatin	4.0	4.9	6.8	-1.6	2.5	2.4	1.8	2.6
Illnesses of father: High blood pressure	1.3	1.7	3.5	0.7	-1.9	-1.5	1.2	-0.8
Alcohol drinker status: Never	0.7	0.9	1.8	-0.2	1.3	1.3	0.1	1.0
Ever smoked	0.7	1.1	2.1	1.0	-0.5	-1.4	1.0	-1.2
Basal metabolic rate	0.5	2.9	7.8	-0.6	1.4	1.2	2.8	1.7
Leg fat percentage (left)	0.7	2.7	7.6	-0.1	-2.8	-0.9	1.8	1.4
Arm fat-free mass (left)	0.3	1.7	4.5	-0.8	-0.0	0.6	2.1	1.8
Number of operations (self-reported)	0.6	0.8	1.5	-1.2	0.4	1.2	0.6	0.9
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.5	-0.9	0.3	0.2	0.7
Irritability	1.2	2.1	4.9	0.2	0.8	0.2	2.2	2.2
Risk taking	1.1	1.7	3.7	-1.3	0.3	1.6	0.4	1.9
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.4	-1.9	0.4	1.1	0.9	1.1
Fractured/broken bones in last 5 years	0.9	1.1	3.8	-1.9	-0.4	0.3	-1.2	0.3
Age started oral contraceptive pill	1.0	1.2	5.0	-0.7	2.2	0.7	0.1	0.5
Diastolic blood pressure, automated reading	1.2	3.7	15.6	1.1	-4.0	-1.1	-0.7	-0.2
Ever depressed for a whole week	0.5	0.7	1.0	-0.7	-0.4	1.0	0.9	0.9
Unable to work because of sickness or disability	2.6	3.3	11.5	-1.6	-1.1	1.0	0.7	3.4
Commuting to job workplace: Cycle	0.6	0.7	1.3	-0.7	1.1	0.5	0.6	1.1
Myopia	0.3	0.4	1.3	0.7	0.6	0.0	-0.1	-1.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.9	1.4	2.0	-0.8	0.1	-1.9
Cholesterol lowering medication	1.0	1.5	2.8	-1.7	1.2	1.3	-0.2	1.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.6	-1.5	-0.4	0.5	1.2	1.6
Pain experienced in last month	1.5	2.5	6.5	1.0	1.9	-0.4	-1.0	-2.6
Supplements: Calcium	1.0	1.1	1.9	0.9	-0.9	-1.4	-0.9	-1.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.6	0.6	0.1	-0.3	-0.3
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.6	-1.7	0.4	1.1	0.3	1.9
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.3	-0.1	0.0	0.1	0.1
Heart disease (siblings)	2.2	2.7	5.7	0.3	1.6	1.2	2.4	1.9
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.9	-0.6	-0.6	0.2	0.8
Pack years of smoking	1.8	2.7	4.8	-1.4	1.0	1.8	2.2	1.6
Impedance of whole body	0.1	0.7	1.6	1.3	0.6	-0.5	-0.7	-0.8
Leg fat mass (left)	0.6	2.5	7.3	-0.5	-1.3	0.1	2.7	1.8
Arm predicted mass (left)	0.4	1.9	4.8	-1.0	-0.1	0.6	2.2	1.8