Hub : Genes

LPP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0351 0.0124 3.2e-03 0.015 0.010 0.015 0.017 0.013 9.7e-06 3.1e-04 7.2e-06 2.1e-06 3.9e-05
2 ROSMAP Brain Pre-frontal Cortex 0.3158 0.0460 2.3e-11 0.206 0.098 0.173 0.194 0.203 5.4e-26 1.5e-12 1.1e-21 2.1e-24 1.5e-25
3 YFS Blood 0.3302 0.0336 0.0e+00 0.111 0.125 0.220 0.188 0.213 3.1e-34 1.1e-38 3.2e-70 2.0e-59 8.2e-68
4 TCGA Pancreatic Adenocarcinoma 0.2320 0.0890 8.5e-03 0.007 0.058 0.029 NA 0.024 1.6e-01 2.0e-03 2.3e-02 NA 3.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.5 2.3 6.8 0.1 -1.6 -2.6 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.9 0.1 -1.0 0.1 -0.1
Depressed Affect (Nagel 2018) 1.6 3.4 10.6 -1.2 -0.6 -1.2 -3.3
Depression (Nagel 2018) 0.3 0.5 1.2 -1.1 -0.6 -0.4 -0.1
Intelligence (Savage-Jansen 2018) 1.0 3.1 6.7 -2.6 1.6 0.9 -1.4
Neuroticism (Nagel 2018) 1.9 4.5 14.4 -1.5 -0.8 -0.9 -3.8
Schizophrenia (2018) 0.6 1.2 4.8 0.2 0.1 2.2 0.1
Schizophrenia vs Biploar Disorder 1.4 1.9 4.4 -0.3 2.1 1.4 -1.0
Worry (Nagel 2018) 0.7 1.5 4.2 -1.3 -0.0 -0.2 -2.1
Alzheimer’s Disease (in mother) 0.3 0.3 0.8 -0.9 0.0 -0.2 -0.8
Alzheimer’s Disease (in father) 4.1 4.5 10.3 -1.9 0.0 -3.2 -2.0
Alzheimer’s Disease (including proxy) 1.9 2.8 5.3 -1.8 0.3 -1.5 -2.3
Crohns Disease (2017) 0.6 1.4 5.2 -0.2 0.6 -0.4 -2.3
Irritable Bowel Disease (IBD) 2.4 5.6 15.9 -1.2 -0.1 -2.3 -4.0
Ulcerative Colitis (UC) 3.2 6.1 16.8 -1.6 -0.1 -2.2 -4.1
Major Depression (MDD) 3.9 4.7 8.3 -2.0 -1.3 -2.2 -2.9
Reaction Time 1.9 3.6 5.8 -1.2 -1.2 -2.4 -2.3
Verbal and Numeric Reasoning (VNR) 1.0 2.4 5.6 -1.4 1.3 0.3 -2.4
Breast Cancer 0.1 0.3 0.7 -0.0 -0.0 -0.6 0.8
Ovarian Cancer 0.7 0.9 3.1 0.1 0.8 0.0 1.8
Prostate Cancer 0.5 0.7 1.8 -0.5 -0.3 -1.4 -0.7
Age at First Birth 0.7 1.0 1.6 -1.1 0.9 1.3 -0.7
Bipolar Disorder (2011) 0.9 0.9 2.7 -0.1 -0.1 0.9 1.6
Body Mass Index (BMI) (2010) 0.3 0.4 0.5 0.4 -0.7 -0.7 -0.6
Coronary Artery Disease (CAD) 1.9 2.2 3.5 -0.1 1.9 1.6 1.7
Crohns Disease (2012) 0.5 0.8 3.1 0.1 -0.1 0.3 -1.8
Mean Putamen Volume 0.3 0.3 0.8 -0.9 -0.0 -0.2 0.7
Fasting Glucose 0.1 0.1 0.2 -0.3 -0.5 -0.5 -0.1
HbA1C 0.7 0.8 2.4 0.3 -0.8 -1.6 -0.2
HDL Cholesterol 0.4 0.6 2.2 0.3 0.4 0.3 1.5
LDL Cholesterol 0.2 0.2 0.7 0.3 0.9 -0.1 -0.4
Lupus 0.4 0.6 1.4 -0.6 -0.7 -1.2 0.0
Neuroticism (2016) 1.7 2.4 8.0 -1.2 0.1 -0.4 -2.8
Primary Biliary Cirrhosis 0.5 0.7 1.5 -0.6 0.8 -0.2 1.2
Rheumatoid Arthritis 0.4 0.6 1.3 -0.6 0.4 -0.7 -1.1
Schizophrenia (2014) 0.9 1.9 5.5 0.8 -1.0 2.3 -0.6
Triglycerides 0.2 0.3 0.7 0.4 -0.8 -0.1 -0.6
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.9 0.3 -1.5 -2.0 -0.3
Ulcerative Colitis 3.3 4.8 14.8 -1.6 -0.1 -1.4 -3.8
Blood Eosinophil Count 1.4 10.9 30.4 -3.5 0.9 0.4 -5.5
Blood Platelet Count 0.0 0.6 0.8 -0.5 0.8 0.9 -0.7
Blood Red Count 0.1 0.7 1.2 -0.8 0.6 -0.7 -1.1
Blood White Count 0.1 0.6 1.4 -1.0 0.4 0.0 -1.2
Heel T-Score 0.3 2.3 5.6 2.4 -1.6 -0.6 -0.8
BMI 0.5 3.2 6.1 -2.2 1.4 0.3 -2.5
Height 0.6 11.1 26.9 3.3 1.6 5.2 2.0
Waist Hip Ratio (WHR) 0.9 4.0 8.3 1.9 -2.0 -0.0 2.9
Systolic Blood Pressure 0.6 2.9 4.8 1.8 -0.4 1.8 2.2
Smoking Status 0.2 0.4 0.9 0.7 -0.2 -1.0 0.3
Allergy or Eczema 1.3 3.5 10.5 -1.8 0.7 0.1 -3.2
Cardiovascular Disease 0.2 0.7 1.5 1.1 -1.2 -0.1 0.1
Hypothyroidism (self reported) 0.5 1.1 2.2 0.6 -1.5 0.9 -1.0
Respiratory disease 0.9 2.1 5.5 -1.5 -0.1 -2.3 -0.8
Type 2 Diabetes (T2D) (2018) 3.9 7.2 13.8 0.8 -3.7 -3.1 -2.1
Lung FEV1/FVC ratio 0.3 1.4 3.6 0.1 1.2 1.9 0.7
Lung FVC 0.1 0.4 0.7 0.3 0.0 -0.8 0.9
Neuroticism 1.2 2.8 7.3 -1.4 -1.0 -0.9 -2.7
Chronotype (morning person) 1.2 2.7 6.0 -0.5 -0.6 -2.0 -2.5
Hair Pigment 0.1 1.7 2.7 -1.6 0.9 -0.6 1.6
Tanning 0.1 1.1 2.1 -0.7 1.0 -1.0 1.4
Hand grip strength (left) 1.0 2.6 6.3 0.6 1.5 1.3 2.5
Number of treatments/medications taken 1.8 3.3 7.2 1.6 -2.7 -1.9 -0.2
Average weekly spirits intake 0.2 0.3 0.7 -0.3 0.6 0.8 0.1
Sensitivity / hurt feelings 0.1 0.2 0.5 -0.4 -0.4 -0.7 -0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.1 -1.4 0.1 -0.5 0.4
Hearing difficulty/problems: Yes 0.3 0.5 1.3 0.5 -1.1 -0.7 -0.3
Relative age of first facial hair 0.5 1.0 3.5 0.4 -0.2 0.5 1.9
Other serious medical condition/disability diagnosed by doctor 2.9 3.7 6.4 -0.1 -1.8 -2.5 -2.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.4 -0.2 -0.6 -1.6 -0.6
Ever had hysterectomy (womb removed) 1.3 1.5 2.3 1.3 -1.0 -1.0 1.5
Systolic blood pressure, automated reading 0.7 2.1 4.0 1.4 -0.1 2.0 1.6
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 3.8 -2.0 1.3 -0.5 -0.7
Angina 0.7 1.0 1.9 1.4 -0.9 -0.9 0.6
Medication for hormone replacement therapy 0.6 0.7 1.4 0.6 -0.9 -1.2 -0.4
Vitamin and mineral supplements 1.2 1.6 2.9 -1.7 1.0 -1.5 0.1
Supplements: Zinc 0.6 0.7 1.4 1.2 -0.9 0.4 -0.4
Medication: Co-codamol 0.7 0.8 1.5 1.2 -0.8 0.9 0.6
Medication: Metformin 1.8 2.5 4.3 0.7 -1.9 -2.1 -1.2
Diabetes (father) 0.4 0.4 1.2 0.1 -0.5 -0.6 -1.1
Diabetes (mother) 1.3 1.6 3.7 0.2 -1.6 -1.9 0.3
Severe depression (siblings) 3.6 4.0 9.6 -1.1 -0.8 -3.1 -2.2
Pack years adult smoking proportion 0.6 1.0 1.8 0.9 -0.8 -1.3 0.8
Impedance of leg (right) 1.9 9.1 19.0 3.1 -1.0 2.6 4.4
Leg fat-free mass (left) 0.6 3.3 7.0 -1.4 2.1 0.3 -2.6
Trunk fat percentage 0.5 2.0 6.5 -1.0 0.8 2.5 -0.1
Hand grip strength (right) 1.7 4.7 7.8 1.8 1.3 2.8 2.5
Townsend deprivation index at recruitment 0.0 0.1 0.2 -0.2 -0.1 0.0 0.5
Current tobacco smoking 0.8 1.2 3.7 0.4 0.8 0.7 1.9
Average weekly fortified wine intake 0.6 0.7 1.0 0.7 -0.7 -1.0 -0.7
Maternal smoking around birth 0.1 0.1 0.2 0.4 -0.4 0.0 0.5
Fed-up feelings 0.9 1.7 5.5 -1.2 0.0 -0.2 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.7 -0.8 -0.8 -0.8 -0.2
Relative age voice broke 0.1 0.2 0.4 0.3 0.3 -0.2 0.6
Taking other prescription medications 2.3 3.5 7.2 0.7 -2.7 -2.5 0.2
Age when periods started (menarche) 0.2 0.4 1.5 0.5 1.2 0.1 0.2
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.6 1.1 -0.8 -0.5 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 1.1 -0.6 0.2 -0.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.4 -1.6 0.9 -1.2 -0.2
Qualifications: CSEs or equivalent 0.2 0.3 0.5 -0.7 -0.3 -0.5 -0.5
Serious illness, injury or assault to yourself 0.3 0.3 0.5 0.2 -0.5 -0.7 0.7
High blood pressure 0.3 0.9 2.2 0.9 -1.5 0.5 0.5
Hayfever, allergic rhinitis or eczema 1.0 2.3 6.1 -1.5 0.6 0.7 -2.5
Multivitamins +/- minerals 1.4 1.8 2.3 1.5 -1.4 1.5 -0.8
Stomach or abdominal pain in last month 1.6 2.0 3.8 -1.9 -0.6 -1.6 -1.1
Supplements: Glucosamine 0.1 0.1 0.4 0.3 -0.3 -0.6 0.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 0.7 -0.2 -1.1 0.6
Medication: Atenolol 0.6 0.7 1.7 -0.9 -0.2 -1.3 -0.5
Medication: Levothyroxine sodium 0.2 0.3 0.4 0.6 -0.5 0.6 0.5
Sitting height 0.3 1.9 4.5 1.3 1.1 2.1 0.5
Chronic bronchitis/emphysema (father) 0.4 0.5 1.1 -0.6 -0.0 -0.7 -1.1
High blood pressure (mother) 1.0 1.4 5.1 -0.3 0.6 -0.1 2.2
Body mass index (BMI) 0.5 2.3 4.3 -1.8 1.0 0.7 -2.1
Impedance of leg (left) 2.0 9.6 20.9 3.0 -1.0 2.8 4.6
Leg predicted mass (left) 0.6 3.3 6.6 -1.4 2.1 0.3 -2.6
Trunk fat mass 0.6 2.6 5.9 -1.3 1.5 2.4 -0.7
Waist circumference 0.3 0.9 1.3 -0.9 0.6 1.1 -1.1
Number of incorrect matches in round 0.6 1.0 2.0 1.4 -1.1 -0.7 0.6
Past tobacco smoking 0.3 0.5 1.8 -1.4 0.4 0.2 0.3
Alcohol usually taken with meals 0.4 0.7 1.4 -0.4 0.4 -1.2 -1.0
Nervous feelings 1.1 2.1 4.3 -2.1 1.3 1.0 -1.1
Frequency of tenseness / restlessness in last 2 weeks 1.3 1.9 4.6 -1.4 -0.1 -2.1 -1.2
Hearing difficulty/problems with background noise 1.2 1.9 3.3 1.8 -1.8 0.2 1.2
Hair/balding pattern: Pattern 2 0.9 1.2 1.8 1.0 -1.4 -0.5 1.3
Had menopause 0.8 1.0 2.9 -0.1 -0.2 -1.7 -1.0
Had other major operations 1.1 1.4 2.7 0.8 -1.6 -0.9 1.2
Forced vital capacity (FVC) 0.3 1.0 1.3 1.1 0.8 1.0 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.8 2.0 -0.9 -0.3 -0.2
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 3.5 -0.3 -1.2 -1.9 -0.7
Qualifications: None of the above 0.2 0.5 1.7 -1.3 0.4 0.2 0.4
Financial difficulties in last 2 years 0.1 0.1 0.2 0.2 -0.4 0.1 0.4
Mouth/teeth dental problems 0.5 0.7 1.6 1.3 -1.1 0.0 0.1
Heart attack 1.0 1.2 2.3 0.2 -1.5 -0.7 -1.5
Allergy 0.9 2.1 3.4 1.8 -1.2 -0.9 1.7
Pain all over the body in last month 0.5 0.5 1.1 -0.6 0.3 -1.1 0.8
Diabetes (self-reported) 2.4 3.6 6.8 -0.7 -2.3 -2.6 -1.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 -0.9 -0.8 -0.6 0.0
Medication: Ramipril 0.7 0.9 1.4 0.8 -1.1 -0.7 -1.2
Medication: Simvastatin 1.4 2.0 3.9 2.0 -1.5 -1.1 0.9
Fluid intelligence score 0.8 1.6 4.5 -1.1 0.7 -0.6 -2.1
Illnesses of siblings 0.6 0.9 1.3 1.1 -1.1 -0.9 0.6
Neuroticism score 1.1 2.4 6.2 -1.8 0.2 -0.1 -2.5
Weight 0.5 2.7 3.6 -1.3 1.9 1.8 -1.5
Impedance of arm (right) 0.4 1.9 6.4 -0.7 -0.4 0.8 2.5
Arm fat percentage (right) 0.5 2.1 4.6 -2.1 1.0 1.3 -1.0
Trunk fat-free mass 0.4 2.6 4.9 -0.6 2.2 0.0 -2.2
Hip circumference 1.1 4.6 6.5 -2.0 2.1 1.8 -2.6
Time employed in main current job 1.4 1.7 2.5 -1.6 1.1 -1.3 1.1
Alcohol intake versus 10 years previously 0.5 0.8 2.8 0.4 0.5 1.7 -0.1
Father’s age at death 0.4 0.6 1.0 -1.0 0.6 -0.5 -0.8
Worrier / anxious feelings 0.5 0.9 2.2 -0.5 -0.7 -0.8 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.9 -1.0 -0.4 0.2 -0.3
Falls in the last year 1.5 2.1 4.8 -1.0 -0.7 -2.2 -1.5
Hair/balding pattern: Pattern 3 0.8 1.2 2.8 -1.7 1.4 0.0 -0.2
Number of live births 0.4 0.5 0.8 -0.5 0.9 0.6 0.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 1.7 1.0 0.7 1.2 1.3
Pulse rate 0.2 0.4 0.9 0.9 0.5 0.7 0.1
Happiness 0.4 0.5 1.0 -0.5 -0.8 -1.0 -0.5
Noisy workplace 3.5 4.3 7.6 -1.3 2.8 2.3 1.6
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 0.5 -0.2 0.0 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.7 -0.7 0.2 -0.4 1.3
Mouth/teeth dental problems: Dentures 1.1 1.9 3.3 -1.1 1.8 0.9 1.5
Asthma 0.4 0.7 1.0 -0.9 0.4 -0.9 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.7 1.3 -1.3 0.1 -0.3
Medication: Cholesterol lowering 1.2 1.9 2.7 1.7 -1.5 -1.5 -0.3
Depression (self-reported) 3.1 3.8 9.1 -1.4 -0.3 -3.0 -2.0
Medication: Lansoprazole 0.7 0.7 2.6 0.6 -1.6 0.2 0.0
Prospective memory result 0.7 0.9 3.0 0.3 0.4 0.6 1.7
Lung cancer (father) 0.7 0.8 2.4 0.8 -0.1 1.6 0.4
Illnesses of mother 0.7 0.9 3.0 0.6 0.5 1.7 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.1 4.0 0.7 0.9 2.0 1.7
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 -0.9 0.7 0.0 -0.5
Impedance of arm (left) 0.4 2.0 4.9 0.7 -1.4 0.6 2.2
Arm fat mass (right) 0.6 2.3 3.1 -1.8 1.4 1.4 -1.6
Trunk predicted mass 0.4 2.4 4.7 -0.6 2.2 -0.1 -2.2
Standing height 0.3 3.2 6.3 1.2 1.9 2.5 1.2
Length of working week for main job 1.9 2.1 4.2 2.0 -1.2 -0.0 1.7
Exposure to tobacco smoke at home 2.3 2.6 5.3 0.6 -1.5 -2.3 -1.6
Breastfed as a baby 0.6 0.8 1.5 -0.0 1.2 -0.3 1.2
Tense / ‘highly strung’ 1.6 2.6 5.9 -0.4 -1.3 -1.6 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.5 -0.6 0.7 -0.5 0.6
Hair/balding pattern: Pattern 4 0.4 1.0 2.3 0.4 -1.5 0.2 -1.2
Birth weight of first child 0.6 1.1 1.7 -1.0 1.1 -1.3 -0.7
Peak expiratory flow (PEF) 0.3 0.7 2.0 0.8 -0.1 -0.1 1.4
Pulse wave reflection index 0.3 0.4 0.9 -0.9 0.1 -0.2 -1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.0 0.2 0.9 0.7 -1.7
Loud music exposure frequency 1.0 1.1 2.2 1.5 -1.3 0.5 0.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.3 -0.2 0.8 0.1 1.5
Mouth/teeth dental problems: Bleeding gums 2.3 3.0 7.9 -1.9 0.4 0.5 -2.8
Blood clot in the leg (DVT) 1.4 1.8 3.6 -1.2 1.9 1.4 -0.5
Medication: Paracetamol 0.1 0.1 0.3 0.5 -0.1 0.4 0.3
Headache pain in last month 1.3 2.3 3.6 1.9 -0.8 1.1 1.9
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.6 0.3 0.1 0.4 1.3
Glaucoma (self-reported) 1.1 1.3 4.9 0.3 0.0 2.2 0.4
Gout (self-reported) 0.5 0.7 2.2 0.1 -0.6 0.3 -1.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.8 0.8 -1.4 1.2 -0.0
Medication: Amlodipine 0.2 0.3 0.8 -0.4 -0.1 -0.6 -0.9
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.8 -1.3 0.7 -0.6 -1.7
Birth weight 0.2 0.4 0.9 0.1 0.8 1.0 0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.1 -1.1 0.2 0.5 -0.3
High blood pressure (siblings) 1.1 1.5 5.8 0.5 0.3 2.4 0.2
Forced vital capacity (FVC), Best measure 0.5 2.0 4.3 0.9 0.6 1.6 2.1
Body fat percentage 0.5 2.0 6.1 -1.1 0.9 2.5 -0.2
Leg fat percentage (right) 0.4 1.5 5.5 -0.0 0.5 2.4 0.2
Arm fat-free mass (right) 0.4 2.1 4.1 -0.1 2.0 0.6 -1.9
Exposure to tobacco smoke outside home 0.4 0.5 1.1 0.7 -1.1 -0.4 0.4
Comparative body size at age 10 0.1 0.2 0.6 -0.3 0.1 0.7 -0.1
Number of full brothers 0.4 0.6 1.8 0.4 -1.3 -0.4 -0.3
Worry too long after embarrassment 0.1 0.1 0.2 -0.4 -0.1 0.1 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 -0.1 -0.4 -0.5 -0.3
Wheeze or whistling in the chest in last year 0.7 1.2 2.3 -1.5 0.6 -1.3 -0.5
Number of children fathered 0.2 0.2 0.3 0.5 0.2 -0.6 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 -0.3 -0.1 0.5 -0.8
Age at first live birth 0.8 1.4 4.1 -0.3 1.1 2.0 0.4
Pulse wave peak to peak time 0.6 0.7 1.3 1.1 -0.7 0.1 1.0
Health satisfaction 0.8 1.1 1.7 -1.1 -0.7 -1.3 -1.0
Shortness of breath walking on level ground 0.8 1.0 2.0 -1.4 1.3 0.2 -0.4
Qualifications: College or University degree 0.3 0.9 1.5 0.9 -0.8 -1.2 -0.9
Eye problems/disorders: None of the above 0.4 0.5 1.5 -0.1 1.2 0.4 0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.3 0.1 -0.5 -0.2
Emphysema/chronic bronchitis 1.4 1.6 3.6 1.6 -0.2 -0.1 1.9
Medication for pain relief, constipation, heartburn 1.5 2.6 4.3 -1.7 2.1 1.8 -0.4
Neck or shoulder pain in last month 0.1 0.1 0.3 0.6 -0.1 0.0 -0.0
Medication: Blood pressure 0.3 0.6 1.3 -0.5 0.3 1.1 -0.8
Angina (self-reported) 0.8 1.1 2.5 1.6 -0.8 -0.6 0.9
Migraine (self-reported) 0.6 0.8 1.4 1.2 -0.9 0.9 -0.2
Medication: Ibuprofen 1.0 1.2 2.5 1.5 -1.6 0.1 0.1
Medication: Allopurinol 0.4 0.5 1.6 0.0 0.3 0.6 -1.3
Medication: Omeprazole 0.8 0.9 1.9 -0.4 -0.9 -1.4 -0.9
Medication: Seretide 50 evohaler 0.3 0.3 1.2 0.1 0.1 0.1 1.1
Mean time to correctly identify matches 2.0 3.8 6.7 -0.4 -1.8 -2.6 -2.2
Heart disease (mother) 1.7 2.0 4.2 1.7 -0.8 0.6 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 2.1 -0.9 1.2 -1.4 -1.4
Whole body fat mass 0.7 2.9 4.5 -1.7 1.7 2.1 -1.2
Leg fat mass (right) 0.5 2.0 4.6 -0.8 1.4 2.1 -0.9
Arm predicted mass (right) 0.5 2.5 5.2 -0.1 2.3 1.1 -1.8
Pulse rate, automated reading 1.2 3.9 8.4 2.6 -0.2 2.9 0.7
Alcohol intake frequency. 0.4 0.9 2.9 -1.7 -0.1 -0.8 -0.2
Comparative height size at age 10 0.1 0.7 1.4 0.6 -0.0 -1.0 -1.2
Number of full sisters 2.6 3.2 8.2 1.8 0.2 1.2 2.9
Suffer from ‘nerves’ 1.7 2.7 4.1 -1.8 2.0 1.3 -1.2
Overall health rating 0.8 1.7 2.9 -0.4 -1.5 -1.7 -1.3
Chest pain or discomfort 0.3 0.4 1.4 -0.3 0.1 1.2 -0.3
Had major operations 0.2 0.3 0.6 -0.5 -0.3 -0.4 -0.8
Age at last live birth 0.8 1.1 1.8 -0.2 1.0 1.3 1.3
Family relationship satisfaction 0.6 0.7 1.6 0.5 -0.8 1.3 0.5
Leg pain on walking 0.3 0.4 1.3 0.0 -0.2 -1.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 5.7 1.5 0.6 1.5 2.4
Commuting to job workplace: Car/motor vehicle 2.5 2.8 6.9 -1.6 2.6 1.2 0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.9 -0.4 1.0 1.4 -0.7
Medication: Aspirin 1.6 2.1 4.7 2.2 -1.5 -0.8 0.9
Supplements: Vitamin C 0.7 0.8 2.3 0.6 0.5 1.5 0.6
Knee pain experienced in last month 0.6 0.9 2.0 0.2 -0.3 -1.4 -1.2
Hypertension (Self-reported) 0.2 0.7 1.4 0.8 -1.2 0.5 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.5 -0.1 -1.3 -0.4 -1.6
Illnesses of father: Heart disease 1.1 1.5 3.0 1.3 -1.7 -1.1 0.1
Illnesses of siblings: Diabetes 0.9 1.1 1.9 -1.4 0.6 -1.0 -1.0
Smoking status: Previous 0.6 0.9 2.3 1.5 -0.9 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.8 0.9 0.1 0.7 1.9
Whole body fat-free mass 0.6 3.2 6.1 -1.0 2.4 0.4 -2.5
Leg fat-free mass (right) 0.6 3.1 6.2 -1.4 2.0 0.3 -2.5
Arm fat percentage (left) 0.3 1.2 2.5 -1.6 0.6 1.1 -1.0
Average weekly red wine intake 0.2 0.4 0.9 -0.9 0.3 -0.6 -0.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 -0.1 -0.5 -1.1 -1.0
Mood swings 1.7 3.1 7.3 -1.6 -0.4 -1.5 -2.7
Loneliness, isolation 0.8 1.1 2.4 -1.6 -0.1 -1.2 -0.7
Long-standing illness, disability or infirmity 2.7 4.2 9.5 -0.3 -1.6 -3.1 -2.1
Ever had bowel cancer screening 0.5 0.6 1.1 -0.9 -0.2 -1.1 -0.6
Diabetes diagnosed by doctor 2.9 4.7 8.3 0.1 -2.9 -2.9 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.8 -1.4 0.9 1.0 -0.2
Friendships satisfaction 0.6 0.7 1.4 0.2 -1.1 -0.1 -1.2
Qualifications: nursing, teaching 0.6 1.0 1.2 0.9 -1.1 -1.0 -1.0
Commuting to job workplace: Walk 0.6 0.6 1.8 1.3 -0.9 -0.2 -0.1
Eye problems/disorders: Cataract 0.4 0.5 1.0 -0.1 -0.3 -0.9 1.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.5 -0.7 0.4 -1.6 -0.5
Medication for cholesterol 2.3 3.5 8.1 -1.9 2.8 0.7 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.6 4.2 8.5 1.5 -0.3 2.5 2.9
Back pain experienced in last month 0.6 0.9 1.1 -1.0 1.1 1.0 0.5
Mineral and other dietary supplements 0.6 0.8 2.6 -0.1 -0.6 -1.6 -0.4
Breast cancer (self-reported) 1.1 1.3 3.2 0.5 -0.9 -1.8 -1.1
Asthma (self-reported) 0.4 0.7 1.2 -1.0 0.3 -1.1 -0.8
Osteoporosis (self-reported) 0.7 0.9 3.5 -1.9 0.2 0.3 -0.1
Osteoarthritis (self-reported) 1.1 1.5 2.5 0.7 -1.6 -1.0 -1.4
Medication: Aspirin 1.1 1.4 2.9 1.7 -1.1 -0.5 1.2
Medication: Gliclazide 1.7 1.9 3.2 0.9 -1.8 -0.6 1.8
Illnesses of father: None of the above (group 1) 0.6 0.7 1.0 -0.5 1.0 0.8 1.0
Smoking status: Current 0.5 0.8 2.4 0.1 0.9 0.4 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.9 0.0 -0.7 -0.9 0.1
Whole body water mass 0.5 2.6 5.3 -0.9 2.1 0.3 -2.3
Leg predicted mass (right) 0.6 3.1 6.3 -1.5 2.0 0.2 -2.5
Arm fat mass (left) 0.5 2.1 3.1 -1.7 1.2 1.0 -1.8
Number of self-reported non-cancer illnesses 0.8 1.3 2.8 -0.4 -1.1 -1.7 -1.1
Average weekly champagne plus white wine intake 1.8 2.4 3.7 0.9 -1.7 -1.5 -1.9
Miserableness 1.3 2.3 8.1 -1.0 -0.0 -0.1 -2.8
Guilty feelings 1.7 2.6 5.2 -2.3 0.4 0.1 -2.3
Wears glasses or contact lenses 1.0 1.2 4.0 -0.5 -0.4 -0.6 -2.0
Ever taken oral contraceptive pill 4.6 5.1 12.4 3.5 -1.9 1.7 1.2
Hearing aid user 0.7 0.8 1.7 0.7 -0.8 1.3 -0.7
Mother’s age at death 1.6 1.9 5.5 0.4 -0.9 -1.2 -2.3
Financial situation satisfaction 0.3 0.4 1.3 0.1 -1.1 0.3 -0.3
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.5 -0.3 0.4 0.1 -0.7
Commuting to job workplace: Public transport 0.2 0.2 0.5 0.3 -0.1 -0.4 -0.7
Eye problems/disorders: Glaucoma 0.7 0.9 3.2 0.4 -0.2 1.8 -0.3
Medication: Blood pressure 0.8 1.6 3.2 0.7 -1.8 -0.8 1.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 -0.3 0.3 -1.1 -0.6
Supplements: Fish oil (including cod liver oil) 1.5 1.9 4.7 -0.5 1.6 2.2 0.6
High cholesterol (Self-reported) 1.3 2.3 4.3 2.1 -2.0 -0.5 0.8
Medication: Bendroflumethiazide 0.4 0.6 2.3 0.5 -1.5 -0.3 -0.0
Medication: Paracetamol 0.1 0.2 0.3 0.4 -0.2 0.4 -0.5
Medication: Lisinopril 0.6 0.8 1.5 -0.4 -1.2 -0.5 -1.1
Medication: Atorvastatin 1.6 2.0 4.1 2.0 -1.9 -0.4 -0.3
Illnesses of father: High blood pressure 0.0 0.0 0.1 -0.1 -0.3 0.2 -0.1
Alcohol drinker status: Never 0.7 0.8 2.8 -0.6 -0.1 -0.3 -1.7
Ever smoked 0.2 0.3 0.7 0.8 0.3 0.5 0.3
Basal metabolic rate 0.5 2.9 5.1 -1.0 2.3 0.7 -2.2
Leg fat percentage (left) 0.4 1.4 5.1 -0.2 0.5 2.2 0.3
Arm fat-free mass (left) 0.5 2.6 5.5 -0.7 2.4 1.1 -1.8
Number of operations (self-reported) 0.7 1.1 2.9 0.5 -1.7 -0.9 0.6
Average weekly beer plus cider intake 0.3 0.4 1.0 0.6 -0.3 0.4 1.0
Irritability 2.2 3.7 13.6 -1.0 -0.3 0.5 -3.7
Risk taking 1.6 2.3 3.6 1.9 -1.7 -1.1 1.2
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.6 0.8 -0.1 -0.1 0.6
Fractured/broken bones in last 5 years 0.3 0.3 1.0 0.2 -1.0 -0.6 -0.1
Age started oral contraceptive pill 0.4 0.5 1.4 -0.1 1.2 0.7 0.2
Diastolic blood pressure, automated reading 0.8 2.5 5.1 2.2 -2.3 -0.1 0.1
Ever depressed for a whole week 0.4 0.5 1.5 -0.0 -0.5 -0.4 -1.2
Unable to work because of sickness or disability 0.8 1.0 3.0 0.4 -1.7 -0.8 -0.5
Commuting to job workplace: Cycle 1.6 2.0 3.6 -0.5 -1.9 -1.5 -1.3
Myopia 0.6 0.8 2.7 0.5 -1.6 0.0 -0.6
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.4 -0.9 1.5 -0.0 -0.2
Cholesterol lowering medication 3.7 5.4 7.3 2.7 -2.6 -0.1 2.7
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.0 -0.9 -0.5 -1.7 -1.6
Pain experienced in last month 0.6 1.0 3.7 -0.7 -0.1 -0.1 -1.9
Supplements: Calcium 1.8 2.0 2.9 -1.2 1.2 1.4 1.7
Basal cell carcinoma (self-reported) 0.6 0.7 1.9 0.2 0.8 0.7 1.4
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.0 0.4 -1.7 -0.7 -1.5
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 4.7 -1.3 2.2 1.9 -0.9
Heart disease (siblings) 0.2 0.3 0.6 -0.5 0.4 -0.8 -0.3
Alcohol drinker status: Previous 0.4 0.4 0.8 -0.3 -0.9 -0.0 0.9
Pack years of smoking 0.5 0.7 1.6 0.6 -0.7 -1.3 0.7
Impedance of whole body 1.1 5.8 13.2 2.0 -1.2 2.1 3.6
Leg fat mass (left) 0.5 1.9 4.0 -0.9 1.4 2.0 -0.9
Arm predicted mass (left) 0.5 2.8 5.2 -0.7 2.3 1.1 -2.1