Hub : Genes

LPP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0351	0.0124	3.2e-03	0.015	0.010	0.015	0.017	0.013	9.7e-06	3.1e-04	7.2e-06	2.1e-06	3.9e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.3158	0.0460	2.3e-11	0.206	0.098	0.173	0.194	0.203	5.4e-26	1.5e-12	1.1e-21	2.1e-24	1.5e-25
3	YFS	Blood	0.3302	0.0336	0.0e+00	0.111	0.125	0.220	0.188	0.213	3.1e-34	1.1e-38	3.2e-70	2.0e-59	8.2e-68
4	TCGA	Pancreatic Adenocarcinoma	0.2320	0.0890	8.5e-03	0.007	0.058	0.029	NA	0.024	1.6e-01	2.0e-03	2.3e-02	NA	3.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.5	2.3	6.8	0.1	-1.6	-2.6	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	0.1	-1.0	0.1	-0.1
Depressed Affect (Nagel 2018)	1.6	3.4	10.6	-1.2	-0.6	-1.2	-3.3
Depression (Nagel 2018)	0.3	0.5	1.2	-1.1	-0.6	-0.4	-0.1
Intelligence (Savage-Jansen 2018)	1.0	3.1	6.7	-2.6	1.6	0.9	-1.4
Neuroticism (Nagel 2018)	1.9	4.5	14.4	-1.5	-0.8	-0.9	-3.8
Schizophrenia (2018)	0.6	1.2	4.8	0.2	0.1	2.2	0.1
Schizophrenia vs Biploar Disorder	1.4	1.9	4.4	-0.3	2.1	1.4	-1.0
Worry (Nagel 2018)	0.7	1.5	4.2	-1.3	-0.0	-0.2	-2.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	-0.9	0.0	-0.2	-0.8
Alzheimer’s Disease (in father)	4.1	4.5	10.3	-1.9	0.0	-3.2	-2.0
Alzheimer’s Disease (including proxy)	1.9	2.8	5.3	-1.8	0.3	-1.5	-2.3
Crohns Disease (2017)	0.6	1.4	5.2	-0.2	0.6	-0.4	-2.3
Irritable Bowel Disease (IBD)	2.4	5.6	15.9	-1.2	-0.1	-2.3	-4.0
Ulcerative Colitis (UC)	3.2	6.1	16.8	-1.6	-0.1	-2.2	-4.1
Major Depression (MDD)	3.9	4.7	8.3	-2.0	-1.3	-2.2	-2.9
Reaction Time	1.9	3.6	5.8	-1.2	-1.2	-2.4	-2.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.6	-1.4	1.3	0.3	-2.4
Breast Cancer	0.1	0.3	0.7	-0.0	-0.0	-0.6	0.8
Ovarian Cancer	0.7	0.9	3.1	0.1	0.8	0.0	1.8
Prostate Cancer	0.5	0.7	1.8	-0.5	-0.3	-1.4	-0.7
Age at First Birth	0.7	1.0	1.6	-1.1	0.9	1.3	-0.7
Bipolar Disorder (2011)	0.9	0.9	2.7	-0.1	-0.1	0.9	1.6
Body Mass Index (BMI) (2010)	0.3	0.4	0.5	0.4	-0.7	-0.7	-0.6
Coronary Artery Disease (CAD)	1.9	2.2	3.5	-0.1	1.9	1.6	1.7
Crohns Disease (2012)	0.5	0.8	3.1	0.1	-0.1	0.3	-1.8
Mean Putamen Volume	0.3	0.3	0.8	-0.9	-0.0	-0.2	0.7
Fasting Glucose	0.1	0.1	0.2	-0.3	-0.5	-0.5	-0.1
HbA1C	0.7	0.8	2.4	0.3	-0.8	-1.6	-0.2
HDL Cholesterol	0.4	0.6	2.2	0.3	0.4	0.3	1.5
LDL Cholesterol	0.2	0.2	0.7	0.3	0.9	-0.1	-0.4
Lupus	0.4	0.6	1.4	-0.6	-0.7	-1.2	0.0
Neuroticism (2016)	1.7	2.4	8.0	-1.2	0.1	-0.4	-2.8
Primary Biliary Cirrhosis	0.5	0.7	1.5	-0.6	0.8	-0.2	1.2
Rheumatoid Arthritis	0.4	0.6	1.3	-0.6	0.4	-0.7	-1.1
Schizophrenia (2014)	0.9	1.9	5.5	0.8	-1.0	2.3	-0.6
Triglycerides	0.2	0.3	0.7	0.4	-0.8	-0.1	-0.6
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.9	0.3	-1.5	-2.0	-0.3
Ulcerative Colitis	3.3	4.8	14.8	-1.6	-0.1	-1.4	-3.8
Blood Eosinophil Count	1.4	10.9	30.4	-3.5	0.9	0.4	-5.5
Blood Platelet Count	0.0	0.6	0.8	-0.5	0.8	0.9	-0.7
Blood Red Count	0.1	0.7	1.2	-0.8	0.6	-0.7	-1.1
Blood White Count	0.1	0.6	1.4	-1.0	0.4	0.0	-1.2
Heel T-Score	0.3	2.3	5.6	2.4	-1.6	-0.6	-0.8
BMI	0.5	3.2	6.1	-2.2	1.4	0.3	-2.5
Height	0.6	11.1	26.9	3.3	1.6	5.2	2.0
Waist Hip Ratio (WHR)	0.9	4.0	8.3	1.9	-2.0	-0.0	2.9
Systolic Blood Pressure	0.6	2.9	4.8	1.8	-0.4	1.8	2.2
Smoking Status	0.2	0.4	0.9	0.7	-0.2	-1.0	0.3
Allergy or Eczema	1.3	3.5	10.5	-1.8	0.7	0.1	-3.2
Cardiovascular Disease	0.2	0.7	1.5	1.1	-1.2	-0.1	0.1
Hypothyroidism (self reported)	0.5	1.1	2.2	0.6	-1.5	0.9	-1.0
Respiratory disease	0.9	2.1	5.5	-1.5	-0.1	-2.3	-0.8
Type 2 Diabetes (T2D) (2018)	3.9	7.2	13.8	0.8	-3.7	-3.1	-2.1
Lung FEV1/FVC ratio	0.3	1.4	3.6	0.1	1.2	1.9	0.7
Lung FVC	0.1	0.4	0.7	0.3	0.0	-0.8	0.9
Neuroticism	1.2	2.8	7.3	-1.4	-1.0	-0.9	-2.7
Chronotype (morning person)	1.2	2.7	6.0	-0.5	-0.6	-2.0	-2.5
Hair Pigment	0.1	1.7	2.7	-1.6	0.9	-0.6	1.6
Tanning	0.1	1.1	2.1	-0.7	1.0	-1.0	1.4
Hand grip strength (left)	1.0	2.6	6.3	0.6	1.5	1.3	2.5
Number of treatments/medications taken	1.8	3.3	7.2	1.6	-2.7	-1.9	-0.2
Average weekly spirits intake	0.2	0.3	0.7	-0.3	0.6	0.8	0.1
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.4	-0.4	-0.7	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.1	-1.4	0.1	-0.5	0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.3	0.5	-1.1	-0.7	-0.3
Relative age of first facial hair	0.5	1.0	3.5	0.4	-0.2	0.5	1.9
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	6.4	-0.1	-1.8	-2.5	-2.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.4	-0.2	-0.6	-1.6	-0.6
Ever had hysterectomy (womb removed)	1.3	1.5	2.3	1.3	-1.0	-1.0	1.5
Systolic blood pressure, automated reading	0.7	2.1	4.0	1.4	-0.1	2.0	1.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	3.8	-2.0	1.3	-0.5	-0.7
Angina	0.7	1.0	1.9	1.4	-0.9	-0.9	0.6
Medication for hormone replacement therapy	0.6	0.7	1.4	0.6	-0.9	-1.2	-0.4
Vitamin and mineral supplements	1.2	1.6	2.9	-1.7	1.0	-1.5	0.1
Supplements: Zinc	0.6	0.7	1.4	1.2	-0.9	0.4	-0.4
Medication: Co-codamol	0.7	0.8	1.5	1.2	-0.8	0.9	0.6
Medication: Metformin	1.8	2.5	4.3	0.7	-1.9	-2.1	-1.2
Diabetes (father)	0.4	0.4	1.2	0.1	-0.5	-0.6	-1.1
Diabetes (mother)	1.3	1.6	3.7	0.2	-1.6	-1.9	0.3
Severe depression (siblings)	3.6	4.0	9.6	-1.1	-0.8	-3.1	-2.2
Pack years adult smoking proportion	0.6	1.0	1.8	0.9	-0.8	-1.3	0.8
Impedance of leg (right)	1.9	9.1	19.0	3.1	-1.0	2.6	4.4
Leg fat-free mass (left)	0.6	3.3	7.0	-1.4	2.1	0.3	-2.6
Trunk fat percentage	0.5	2.0	6.5	-1.0	0.8	2.5	-0.1
Hand grip strength (right)	1.7	4.7	7.8	1.8	1.3	2.8	2.5
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.2	-0.1	0.0	0.5
Current tobacco smoking	0.8	1.2	3.7	0.4	0.8	0.7	1.9
Average weekly fortified wine intake	0.6	0.7	1.0	0.7	-0.7	-1.0	-0.7
Maternal smoking around birth	0.1	0.1	0.2	0.4	-0.4	0.0	0.5
Fed-up feelings	0.9	1.7	5.5	-1.2	0.0	-0.2	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	-0.8	-0.8	-0.8	-0.2
Relative age voice broke	0.1	0.2	0.4	0.3	0.3	-0.2	0.6
Taking other prescription medications	2.3	3.5	7.2	0.7	-2.7	-2.5	0.2
Age when periods started (menarche)	0.2	0.4	1.5	0.5	1.2	0.1	0.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.6	1.1	-0.8	-0.5	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	1.1	-0.6	0.2	-0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.4	-1.6	0.9	-1.2	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.7	-0.3	-0.5	-0.5
Serious illness, injury or assault to yourself	0.3	0.3	0.5	0.2	-0.5	-0.7	0.7
High blood pressure	0.3	0.9	2.2	0.9	-1.5	0.5	0.5
Hayfever, allergic rhinitis or eczema	1.0	2.3	6.1	-1.5	0.6	0.7	-2.5
Multivitamins +/- minerals	1.4	1.8	2.3	1.5	-1.4	1.5	-0.8
Stomach or abdominal pain in last month	1.6	2.0	3.8	-1.9	-0.6	-1.6	-1.1
Supplements: Glucosamine	0.1	0.1	0.4	0.3	-0.3	-0.6	0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.7	-0.2	-1.1	0.6
Medication: Atenolol	0.6	0.7	1.7	-0.9	-0.2	-1.3	-0.5
Medication: Levothyroxine sodium	0.2	0.3	0.4	0.6	-0.5	0.6	0.5
Sitting height	0.3	1.9	4.5	1.3	1.1	2.1	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	-0.6	-0.0	-0.7	-1.1
High blood pressure (mother)	1.0	1.4	5.1	-0.3	0.6	-0.1	2.2
Body mass index (BMI)	0.5	2.3	4.3	-1.8	1.0	0.7	-2.1
Impedance of leg (left)	2.0	9.6	20.9	3.0	-1.0	2.8	4.6
Leg predicted mass (left)	0.6	3.3	6.6	-1.4	2.1	0.3	-2.6
Trunk fat mass	0.6	2.6	5.9	-1.3	1.5	2.4	-0.7
Waist circumference	0.3	0.9	1.3	-0.9	0.6	1.1	-1.1
Number of incorrect matches in round	0.6	1.0	2.0	1.4	-1.1	-0.7	0.6
Past tobacco smoking	0.3	0.5	1.8	-1.4	0.4	0.2	0.3
Alcohol usually taken with meals	0.4	0.7	1.4	-0.4	0.4	-1.2	-1.0
Nervous feelings	1.1	2.1	4.3	-2.1	1.3	1.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.3	1.9	4.6	-1.4	-0.1	-2.1	-1.2
Hearing difficulty/problems with background noise	1.2	1.9	3.3	1.8	-1.8	0.2	1.2
Hair/balding pattern: Pattern 2	0.9	1.2	1.8	1.0	-1.4	-0.5	1.3
Had menopause	0.8	1.0	2.9	-0.1	-0.2	-1.7	-1.0
Had other major operations	1.1	1.4	2.7	0.8	-1.6	-0.9	1.2
Forced vital capacity (FVC)	0.3	1.0	1.3	1.1	0.8	1.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.8	2.0	-0.9	-0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.5	-0.3	-1.2	-1.9	-0.7
Qualifications: None of the above	0.2	0.5	1.7	-1.3	0.4	0.2	0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	0.2	-0.4	0.1	0.4
Mouth/teeth dental problems	0.5	0.7	1.6	1.3	-1.1	0.0	0.1
Heart attack	1.0	1.2	2.3	0.2	-1.5	-0.7	-1.5
Allergy	0.9	2.1	3.4	1.8	-1.2	-0.9	1.7
Pain all over the body in last month	0.5	0.5	1.1	-0.6	0.3	-1.1	0.8
Diabetes (self-reported)	2.4	3.6	6.8	-0.7	-2.3	-2.6	-1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.9	-0.8	-0.6	0.0
Medication: Ramipril	0.7	0.9	1.4	0.8	-1.1	-0.7	-1.2
Medication: Simvastatin	1.4	2.0	3.9	2.0	-1.5	-1.1	0.9
Fluid intelligence score	0.8	1.6	4.5	-1.1	0.7	-0.6	-2.1
Illnesses of siblings	0.6	0.9	1.3	1.1	-1.1	-0.9	0.6
Neuroticism score	1.1	2.4	6.2	-1.8	0.2	-0.1	-2.5
Weight	0.5	2.7	3.6	-1.3	1.9	1.8	-1.5
Impedance of arm (right)	0.4	1.9	6.4	-0.7	-0.4	0.8	2.5
Arm fat percentage (right)	0.5	2.1	4.6	-2.1	1.0	1.3	-1.0
Trunk fat-free mass	0.4	2.6	4.9	-0.6	2.2	0.0	-2.2
Hip circumference	1.1	4.6	6.5	-2.0	2.1	1.8	-2.6
Time employed in main current job	1.4	1.7	2.5	-1.6	1.1	-1.3	1.1
Alcohol intake versus 10 years previously	0.5	0.8	2.8	0.4	0.5	1.7	-0.1
Father’s age at death	0.4	0.6	1.0	-1.0	0.6	-0.5	-0.8
Worrier / anxious feelings	0.5	0.9	2.2	-0.5	-0.7	-0.8	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-1.0	-0.4	0.2	-0.3
Falls in the last year	1.5	2.1	4.8	-1.0	-0.7	-2.2	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.8	-1.7	1.4	0.0	-0.2
Number of live births	0.4	0.5	0.8	-0.5	0.9	0.6	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.7	1.0	0.7	1.2	1.3
Pulse rate	0.2	0.4	0.9	0.9	0.5	0.7	0.1
Happiness	0.4	0.5	1.0	-0.5	-0.8	-1.0	-0.5
Noisy workplace	3.5	4.3	7.6	-1.3	2.8	2.3	1.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.5	-0.2	0.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	-0.7	0.2	-0.4	1.3
Mouth/teeth dental problems: Dentures	1.1	1.9	3.3	-1.1	1.8	0.9	1.5
Asthma	0.4	0.7	1.0	-0.9	0.4	-0.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.7	1.3	-1.3	0.1	-0.3
Medication: Cholesterol lowering	1.2	1.9	2.7	1.7	-1.5	-1.5	-0.3
Depression (self-reported)	3.1	3.8	9.1	-1.4	-0.3	-3.0	-2.0
Medication: Lansoprazole	0.7	0.7	2.6	0.6	-1.6	0.2	0.0
Prospective memory result	0.7	0.9	3.0	0.3	0.4	0.6	1.7
Lung cancer (father)	0.7	0.8	2.4	0.8	-0.1	1.6	0.4
Illnesses of mother	0.7	0.9	3.0	0.6	0.5	1.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	4.0	0.7	0.9	2.0	1.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.9	0.7	0.0	-0.5
Impedance of arm (left)	0.4	2.0	4.9	0.7	-1.4	0.6	2.2
Arm fat mass (right)	0.6	2.3	3.1	-1.8	1.4	1.4	-1.6
Trunk predicted mass	0.4	2.4	4.7	-0.6	2.2	-0.1	-2.2
Standing height	0.3	3.2	6.3	1.2	1.9	2.5	1.2
Length of working week for main job	1.9	2.1	4.2	2.0	-1.2	-0.0	1.7
Exposure to tobacco smoke at home	2.3	2.6	5.3	0.6	-1.5	-2.3	-1.6
Breastfed as a baby	0.6	0.8	1.5	-0.0	1.2	-0.3	1.2
Tense / ‘highly strung’	1.6	2.6	5.9	-0.4	-1.3	-1.6	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	-0.6	0.7	-0.5	0.6
Hair/balding pattern: Pattern 4	0.4	1.0	2.3	0.4	-1.5	0.2	-1.2
Birth weight of first child	0.6	1.1	1.7	-1.0	1.1	-1.3	-0.7
Peak expiratory flow (PEF)	0.3	0.7	2.0	0.8	-0.1	-0.1	1.4
Pulse wave reflection index	0.3	0.4	0.9	-0.9	0.1	-0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.0	0.2	0.9	0.7	-1.7
Loud music exposure frequency	1.0	1.1	2.2	1.5	-1.3	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	-0.2	0.8	0.1	1.5
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	7.9	-1.9	0.4	0.5	-2.8
Blood clot in the leg (DVT)	1.4	1.8	3.6	-1.2	1.9	1.4	-0.5
Medication: Paracetamol	0.1	0.1	0.3	0.5	-0.1	0.4	0.3
Headache pain in last month	1.3	2.3	3.6	1.9	-0.8	1.1	1.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.6	0.3	0.1	0.4	1.3
Glaucoma (self-reported)	1.1	1.3	4.9	0.3	0.0	2.2	0.4
Gout (self-reported)	0.5	0.7	2.2	0.1	-0.6	0.3	-1.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	0.8	-1.4	1.2	-0.0
Medication: Amlodipine	0.2	0.3	0.8	-0.4	-0.1	-0.6	-0.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.8	-1.3	0.7	-0.6	-1.7
Birth weight	0.2	0.4	0.9	0.1	0.8	1.0	0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	-1.1	0.2	0.5	-0.3
High blood pressure (siblings)	1.1	1.5	5.8	0.5	0.3	2.4	0.2
Forced vital capacity (FVC), Best measure	0.5	2.0	4.3	0.9	0.6	1.6	2.1
Body fat percentage	0.5	2.0	6.1	-1.1	0.9	2.5	-0.2
Leg fat percentage (right)	0.4	1.5	5.5	-0.0	0.5	2.4	0.2
Arm fat-free mass (right)	0.4	2.1	4.1	-0.1	2.0	0.6	-1.9
Exposure to tobacco smoke outside home	0.4	0.5	1.1	0.7	-1.1	-0.4	0.4
Comparative body size at age 10	0.1	0.2	0.6	-0.3	0.1	0.7	-0.1
Number of full brothers	0.4	0.6	1.8	0.4	-1.3	-0.4	-0.3
Worry too long after embarrassment	0.1	0.1	0.2	-0.4	-0.1	0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	-0.4	-0.5	-0.3
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	-1.5	0.6	-1.3	-0.5
Number of children fathered	0.2	0.2	0.3	0.5	0.2	-0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.3	-0.1	0.5	-0.8
Age at first live birth	0.8	1.4	4.1	-0.3	1.1	2.0	0.4
Pulse wave peak to peak time	0.6	0.7	1.3	1.1	-0.7	0.1	1.0
Health satisfaction	0.8	1.1	1.7	-1.1	-0.7	-1.3	-1.0
Shortness of breath walking on level ground	0.8	1.0	2.0	-1.4	1.3	0.2	-0.4
Qualifications: College or University degree	0.3	0.9	1.5	0.9	-0.8	-1.2	-0.9
Eye problems/disorders: None of the above	0.4	0.5	1.5	-0.1	1.2	0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.1	-0.5	-0.2
Emphysema/chronic bronchitis	1.4	1.6	3.6	1.6	-0.2	-0.1	1.9
Medication for pain relief, constipation, heartburn	1.5	2.6	4.3	-1.7	2.1	1.8	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.3	0.6	-0.1	0.0	-0.0
Medication: Blood pressure	0.3	0.6	1.3	-0.5	0.3	1.1	-0.8
Angina (self-reported)	0.8	1.1	2.5	1.6	-0.8	-0.6	0.9
Migraine (self-reported)	0.6	0.8	1.4	1.2	-0.9	0.9	-0.2
Medication: Ibuprofen	1.0	1.2	2.5	1.5	-1.6	0.1	0.1
Medication: Allopurinol	0.4	0.5	1.6	0.0	0.3	0.6	-1.3
Medication: Omeprazole	0.8	0.9	1.9	-0.4	-0.9	-1.4	-0.9
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.1	0.1	0.1	1.1
Mean time to correctly identify matches	2.0	3.8	6.7	-0.4	-1.8	-2.6	-2.2
Heart disease (mother)	1.7	2.0	4.2	1.7	-0.8	0.6	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.1	-0.9	1.2	-1.4	-1.4
Whole body fat mass	0.7	2.9	4.5	-1.7	1.7	2.1	-1.2
Leg fat mass (right)	0.5	2.0	4.6	-0.8	1.4	2.1	-0.9
Arm predicted mass (right)	0.5	2.5	5.2	-0.1	2.3	1.1	-1.8
Pulse rate, automated reading	1.2	3.9	8.4	2.6	-0.2	2.9	0.7
Alcohol intake frequency.	0.4	0.9	2.9	-1.7	-0.1	-0.8	-0.2
Comparative height size at age 10	0.1	0.7	1.4	0.6	-0.0	-1.0	-1.2
Number of full sisters	2.6	3.2	8.2	1.8	0.2	1.2	2.9
Suffer from ‘nerves’	1.7	2.7	4.1	-1.8	2.0	1.3	-1.2
Overall health rating	0.8	1.7	2.9	-0.4	-1.5	-1.7	-1.3
Chest pain or discomfort	0.3	0.4	1.4	-0.3	0.1	1.2	-0.3
Had major operations	0.2	0.3	0.6	-0.5	-0.3	-0.4	-0.8
Age at last live birth	0.8	1.1	1.8	-0.2	1.0	1.3	1.3
Family relationship satisfaction	0.6	0.7	1.6	0.5	-0.8	1.3	0.5
Leg pain on walking	0.3	0.4	1.3	0.0	-0.2	-1.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	5.7	1.5	0.6	1.5	2.4
Commuting to job workplace: Car/motor vehicle	2.5	2.8	6.9	-1.6	2.6	1.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.9	-0.4	1.0	1.4	-0.7
Medication: Aspirin	1.6	2.1	4.7	2.2	-1.5	-0.8	0.9
Supplements: Vitamin C	0.7	0.8	2.3	0.6	0.5	1.5	0.6
Knee pain experienced in last month	0.6	0.9	2.0	0.2	-0.3	-1.4	-1.2
Hypertension (Self-reported)	0.2	0.7	1.4	0.8	-1.2	0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.5	-0.1	-1.3	-0.4	-1.6
Illnesses of father: Heart disease	1.1	1.5	3.0	1.3	-1.7	-1.1	0.1
Illnesses of siblings: Diabetes	0.9	1.1	1.9	-1.4	0.6	-1.0	-1.0
Smoking status: Previous	0.6	0.9	2.3	1.5	-0.9	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.8	0.9	0.1	0.7	1.9
Whole body fat-free mass	0.6	3.2	6.1	-1.0	2.4	0.4	-2.5
Leg fat-free mass (right)	0.6	3.1	6.2	-1.4	2.0	0.3	-2.5
Arm fat percentage (left)	0.3	1.2	2.5	-1.6	0.6	1.1	-1.0
Average weekly red wine intake	0.2	0.4	0.9	-0.9	0.3	-0.6	-0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	-0.1	-0.5	-1.1	-1.0
Mood swings	1.7	3.1	7.3	-1.6	-0.4	-1.5	-2.7
Loneliness, isolation	0.8	1.1	2.4	-1.6	-0.1	-1.2	-0.7
Long-standing illness, disability or infirmity	2.7	4.2	9.5	-0.3	-1.6	-3.1	-2.1
Ever had bowel cancer screening	0.5	0.6	1.1	-0.9	-0.2	-1.1	-0.6
Diabetes diagnosed by doctor	2.9	4.7	8.3	0.1	-2.9	-2.9	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.8	-1.4	0.9	1.0	-0.2
Friendships satisfaction	0.6	0.7	1.4	0.2	-1.1	-0.1	-1.2
Qualifications: nursing, teaching	0.6	1.0	1.2	0.9	-1.1	-1.0	-1.0
Commuting to job workplace: Walk	0.6	0.6	1.8	1.3	-0.9	-0.2	-0.1
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.1	-0.3	-0.9	1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.5	-0.7	0.4	-1.6	-0.5
Medication for cholesterol	2.3	3.5	8.1	-1.9	2.8	0.7	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.6	4.2	8.5	1.5	-0.3	2.5	2.9
Back pain experienced in last month	0.6	0.9	1.1	-1.0	1.1	1.0	0.5
Mineral and other dietary supplements	0.6	0.8	2.6	-0.1	-0.6	-1.6	-0.4
Breast cancer (self-reported)	1.1	1.3	3.2	0.5	-0.9	-1.8	-1.1
Asthma (self-reported)	0.4	0.7	1.2	-1.0	0.3	-1.1	-0.8
Osteoporosis (self-reported)	0.7	0.9	3.5	-1.9	0.2	0.3	-0.1
Osteoarthritis (self-reported)	1.1	1.5	2.5	0.7	-1.6	-1.0	-1.4
Medication: Aspirin	1.1	1.4	2.9	1.7	-1.1	-0.5	1.2
Medication: Gliclazide	1.7	1.9	3.2	0.9	-1.8	-0.6	1.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.0	-0.5	1.0	0.8	1.0
Smoking status: Current	0.5	0.8	2.4	0.1	0.9	0.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	0.0	-0.7	-0.9	0.1
Whole body water mass	0.5	2.6	5.3	-0.9	2.1	0.3	-2.3
Leg predicted mass (right)	0.6	3.1	6.3	-1.5	2.0	0.2	-2.5
Arm fat mass (left)	0.5	2.1	3.1	-1.7	1.2	1.0	-1.8
Number of self-reported non-cancer illnesses	0.8	1.3	2.8	-0.4	-1.1	-1.7	-1.1
Average weekly champagne plus white wine intake	1.8	2.4	3.7	0.9	-1.7	-1.5	-1.9
Miserableness	1.3	2.3	8.1	-1.0	-0.0	-0.1	-2.8
Guilty feelings	1.7	2.6	5.2	-2.3	0.4	0.1	-2.3
Wears glasses or contact lenses	1.0	1.2	4.0	-0.5	-0.4	-0.6	-2.0
Ever taken oral contraceptive pill	4.6	5.1	12.4	3.5	-1.9	1.7	1.2
Hearing aid user	0.7	0.8	1.7	0.7	-0.8	1.3	-0.7
Mother’s age at death	1.6	1.9	5.5	0.4	-0.9	-1.2	-2.3
Financial situation satisfaction	0.3	0.4	1.3	0.1	-1.1	0.3	-0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.3	0.4	0.1	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.3	-0.1	-0.4	-0.7
Eye problems/disorders: Glaucoma	0.7	0.9	3.2	0.4	-0.2	1.8	-0.3
Medication: Blood pressure	0.8	1.6	3.2	0.7	-1.8	-0.8	1.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-0.3	0.3	-1.1	-0.6
Supplements: Fish oil (including cod liver oil)	1.5	1.9	4.7	-0.5	1.6	2.2	0.6
High cholesterol (Self-reported)	1.3	2.3	4.3	2.1	-2.0	-0.5	0.8
Medication: Bendroflumethiazide	0.4	0.6	2.3	0.5	-1.5	-0.3	-0.0
Medication: Paracetamol	0.1	0.2	0.3	0.4	-0.2	0.4	-0.5
Medication: Lisinopril	0.6	0.8	1.5	-0.4	-1.2	-0.5	-1.1
Medication: Atorvastatin	1.6	2.0	4.1	2.0	-1.9	-0.4	-0.3
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.1
Alcohol drinker status: Never	0.7	0.8	2.8	-0.6	-0.1	-0.3	-1.7
Ever smoked	0.2	0.3	0.7	0.8	0.3	0.5	0.3
Basal metabolic rate	0.5	2.9	5.1	-1.0	2.3	0.7	-2.2
Leg fat percentage (left)	0.4	1.4	5.1	-0.2	0.5	2.2	0.3
Arm fat-free mass (left)	0.5	2.6	5.5	-0.7	2.4	1.1	-1.8
Number of operations (self-reported)	0.7	1.1	2.9	0.5	-1.7	-0.9	0.6
Average weekly beer plus cider intake	0.3	0.4	1.0	0.6	-0.3	0.4	1.0
Irritability	2.2	3.7	13.6	-1.0	-0.3	0.5	-3.7
Risk taking	1.6	2.3	3.6	1.9	-1.7	-1.1	1.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.8	-0.1	-0.1	0.6
Fractured/broken bones in last 5 years	0.3	0.3	1.0	0.2	-1.0	-0.6	-0.1
Age started oral contraceptive pill	0.4	0.5	1.4	-0.1	1.2	0.7	0.2
Diastolic blood pressure, automated reading	0.8	2.5	5.1	2.2	-2.3	-0.1	0.1
Ever depressed for a whole week	0.4	0.5	1.5	-0.0	-0.5	-0.4	-1.2
Unable to work because of sickness or disability	0.8	1.0	3.0	0.4	-1.7	-0.8	-0.5
Commuting to job workplace: Cycle	1.6	2.0	3.6	-0.5	-1.9	-1.5	-1.3
Myopia	0.6	0.8	2.7	0.5	-1.6	0.0	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.4	-0.9	1.5	-0.0	-0.2
Cholesterol lowering medication	3.7	5.4	7.3	2.7	-2.6	-0.1	2.7
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.0	-0.9	-0.5	-1.7	-1.6
Pain experienced in last month	0.6	1.0	3.7	-0.7	-0.1	-0.1	-1.9
Supplements: Calcium	1.8	2.0	2.9	-1.2	1.2	1.4	1.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	0.2	0.8	0.7	1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.0	0.4	-1.7	-0.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.7	-1.3	2.2	1.9	-0.9
Heart disease (siblings)	0.2	0.3	0.6	-0.5	0.4	-0.8	-0.3
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.3	-0.9	-0.0	0.9
Pack years of smoking	0.5	0.7	1.6	0.6	-0.7	-1.3	0.7
Impedance of whole body	1.1	5.8	13.2	2.0	-1.2	2.1	3.6
Leg fat mass (left)	0.5	1.9	4.0	-0.9	1.4	2.0	-0.9
Arm predicted mass (left)	0.5	2.8	5.2	-0.7	2.3	1.1	-2.1