TWAS hub - LPXN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1040	0.0540	8.4e-03	0.014	NA	-0.001	NA	0.013	6.0e-02	NA	3.4e-01	NA	6.4e-02
2	GTEx	Spleen	0.3170	0.1080	1.4e-03	0.001	NA	0.038	NA	0.010	3.0e-01	NA	3.8e-02	NA	1.8e-01
3	METSIM	Adipose	0.0517	0.0230	2.4e-03	-0.002	0.005	0.004	0.006	-0.001	9.8e-01	4.9e-02	7.1e-02	3.4e-02	5.0e-01
4	YFS	Blood	0.1455	0.0277	0.0e+00	0.132	0.125	0.132	0.137	0.132	6.8e-41	8.4e-39	5.6e-41	2.1e-42	8.6e-41
5	TCGA	Breast Invasive Carcinoma	0.0491	0.0230	3.1e-08	0.037	0.044	0.039	NA	0.034	3.2e-08	2.1e-09	1.8e-08	NA	1.2e-07
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1470	0.0544	1.2e-06	0.084	0.071	0.075	NA	0.080	1.1e-09	1.9e-08	7.3e-09	NA	2.6e-09
7	TCGA	Brain Lower Grade Glioma	0.0487	0.0292	2.6e-03	0.007	0.006	0.017	NA	0.005	4.9e-02	6.5e-02	4.3e-03	NA	8.3e-02
8	TCGA	Lung Adenocarcinoma	0.0406	0.0218	5.9e-04	0.039	0.002	0.029	NA	0.035	2.1e-05	1.7e-01	2.4e-04	NA	6.0e-05
9	TCGA	Lung Squamous Cell Carcinoma	0.0693	0.0324	5.0e-06	0.043	0.049	0.050	NA	0.046	1.2e-05	3.1e-06	2.3e-06	NA	5.3e-06
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.1210	0.0560	1.0e-06	0.091	0.108	0.099	NA	0.114	9.4e-07	9.5e-08	3.3e-07	NA	4.4e-08
11	TCGA	Prostate Adenocarcinoma	0.0822	0.0452	1.6e-04	0.040	0.032	0.016	NA	0.012	4.2e-05	2.6e-04	8.0e-03	NA	1.8e-02
12	TCGA	Testicular Germ Cell Tumors	0.2100	0.0850	3.4e-05	0.103	0.016	0.053	NA	0.070	1.7e-04	8.8e-02	5.9e-03	NA	1.7e-03
13	TCGA	Thyroid Carcinoma	0.1200	0.0520	3.7e-08	0.094	0.080	0.091	NA	0.078	1.9e-09	3.2e-08	3.8e-09	NA	5.1e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Irritable Bowel Disease (IBD)	6.6	15.6	23.9	-2.0	-3.8	-3.3	-4.3	-4.5	-4.3	-3.8	-4.4	-3.2	-3.5	-4.9	-4.4	-4.2
Ulcerative Colitis (UC)	6.3	11.8	19.3	-0.9	-3.4	-2.9	-3.7	-4.1	-3.7	-3.7	-3.8	-2.7	-2.6	-4.4	-3.8	-3.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.6	6.7	12.0	0.8	-1.3	-1.3	-2.8	-3.3	-2.9	-3.5	-2.9	-3.1	-2.0	-2.1	-2.9	-3.1
Hearing difficulty/problems with background noise	4.8	7.6	13.8	0.9	-2.2	-1.9	-3.0	-3.6	-3.0	-3.7	-3.1	-2.8	-1.7	-2.5	-3.1	-3.1
Myopia	4.8	7.0	9.8	-0.9	-3.1	-1.8	-2.8	-2.6	-2.8	-2.8	-2.8	-2.7	-2.7	-2.8	-2.8	-2.7
Blood Platelet Count	4.6	53.6	78.7	-1.5	-6.6	-8.5	-7.5	-8.5	-7.7	-8.9	-7.8	-5.9	-5.9	-8.2	-7.8	-7.4
Wears glasses or contact lenses	4.5	5.2	7.3	-0.4	-1.5	-1.3	-2.6	-2.7	-2.6	-2.1	-2.6	-2.5	-2.2	-2.5	-2.6	-2.6
Ever taken oral contraceptive pill	4.1	4.6	8.4	-1.0	2.7	1.2	2.2	2.4	2.3	2.9	2.3	2.1	1.7	2.1	2.3	2.0
Alzheimer’s Disease (in father)	3.9	4.2	5.5	-1.0	-2.2	-1.3	-2.2	-2.1	-2.1	-2.3	-2.1	-2.0	-2.3	-2.2	-2.1	-2.3
Bipolar Disorder (2011)	3.6	3.4	7.8	0.3	-0.7	-1.6	-2.1	-2.3	0.0	-2.8	-2.2	-1.7	-1.3	-2.2	-2.2	-2.2
Ulcerative Colitis	3.5	5.0	8.0	-0.2	-2.0	-1.8	-2.5	-2.8	-2.5	-2.5	-2.6	-1.7	-1.4	-2.8	-2.6	-2.2
Crohns Disease (2017)	3.4	7.5	10.3	-2.2	-2.4	-2.2	-3.0	-2.9	-3.0	-2.0	-3.0	-2.3	-2.9	-3.2	-3.0	-3.1
Medication: Paracetamol	3.4	5.3	9.7	-2.4	-1.4	-2.8	-2.3	-2.2	-2.3	-1.9	-2.3	-1.4	-2.5	-3.1	-2.3	-2.3
Medication: Atenolol	3.3	4.1	8.4	-1.8	-1.6	-1.8	-2.2	-2.2	-2.2	-1.8	-2.3	-1.2	-1.6	-2.9	-2.3	-2.0
Heart disease (siblings)	3.3	4.0	9.6	1.0	0.0	-2.0	-2.0	-2.3	-2.1	-3.1	-2.1	-1.7	-1.5	-2.5	-2.1	-2.1
Crohns Disease (2012)	3.2	5.1	6.9	-1.4	-2.2	-1.6	-2.6	-2.5	-2.6	-1.4	-2.5	-2.3	-2.3	-2.4	-2.5	-2.6
Illnesses of siblings	3.2	4.5	6.7	0.3	1.7	2.1	2.2	2.5	2.3	2.6	2.3	1.6	1.7	2.5	2.3	2.2
Supplements: Zinc	3.1	3.4	6.1	-2.1	-1.8	-2.5	-1.8	-1.4	-1.9	-0.9	-1.9	-1.6	-2.3	-1.7	-1.9	-1.8
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	5.3	0.5	2.1	1.4	2.2	2.1	2.2	2.3	2.2	1.9	2.0	2.3	2.2	2.1
Worrier / anxious feelings	2.8	5.2	16.0	-0.4	-0.8	-4.0	-2.1	-2.7	-2.2	-3.0	-2.2	-1.5	-1.0	-2.8	-2.2	-2.1
Alzheimer’s Disease (including proxy)	2.7	3.9	6.8	0.2	-1.7	-2.2	-2.0	-1.7	-2.1	-2.2	-2.1	-2.4	-2.6	-1.4	-2.1	-1.8
Had menopause	2.7	3.4	7.6	2.8	-1.0	-0.9	-1.8	-2.1	-1.9	-2.5	-1.9	-2.1	-1.1	-1.3	-1.9	-1.9
Pulse wave reflection index	2.5	3.1	4.6	-0.0	-1.5	-0.6	-2.0	-2.2	-2.0	-2.0	-2.0	-1.8	-1.7	-1.6	-2.0	-1.9
Risk taking	2.5	3.6	5.2	0.0	0.3	1.3	2.2	2.3	2.2	2.1	2.2	2.1	1.8	1.8	2.2	2.2
Worry (Nagel 2018)	2.4	5.0	11.5	-0.7	-0.9	-3.4	-2.3	-2.5	-2.4	-2.3	-2.4	-1.7	-1.4	-2.9	-2.4	-2.2
Ever had prostate specific antigen (PSA) test	2.4	2.7	5.9	-2.4	-0.9	-1.7	-1.7	-1.3	-1.7	-0.1	-1.6	-1.5	-2.1	-1.8	-1.6	-1.7
Respiratory disease	2.3	5.1	7.4	2.2	2.6	1.0	2.5	2.5	2.5	1.3	2.5	1.9	1.9	2.5	2.5	2.7
Alcohol drinker status: Never	2.3	2.7	12.4	-3.5	-2.5	-1.2	-1.2	-0.7	-1.2	-0.2	-1.3	-0.4	-2.1	-1.8	-1.3	-1.0
Prospective memory result	2.2	2.7	5.0	0.6	-1.0	-2.2	-1.6	-1.6	-1.7	-2.0	-1.7	-1.2	-1.7	-2.2	-1.7	-1.5
Number of children fathered	2.2	2.4	4.3	-1.4	-1.7	1.6	1.5	1.7	1.6	1.7	1.6	2.1	1.1	0.9	1.6	1.5
Qualifications: nursing, teaching	2.1	3.2	4.9	-2.0	-2.2	0.0	-2.0	-1.8	-1.9	-1.1	-1.9	-1.6	-2.0	-1.7	-1.9	-2.0
Bipolar Disorder or Schizophrenia	2.0	5.0	13.9	1.0	-0.3	-1.5	-2.3	-2.7	-2.4	-3.7	-2.4	-1.8	-1.6	-2.6	-2.4	-2.3
Hypothyroidism (self reported)	2.0	4.5	12.0	1.3	-2.0	-1.9	-2.1	-2.8	-2.0	-3.5	-2.0	-1.8	-0.9	-2.0	-2.0	-2.3
Breast cancer (self-reported)	2.0	2.4	4.3	1.5	0.5	1.5	1.7	1.2	1.7	0.0	1.7	2.0	2.1	1.2	1.7	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.9	-1.0	-0.6	0.5	1.7	1.7	1.6	1.6	1.6	2.2	1.4	1.1	1.6	1.8
Neuroticism (Nagel 2018)	1.8	4.3	13.2	-1.2	-0.8	-3.6	-2.0	-2.1	-2.0	-2.1	-2.0	-1.3	-1.7	-2.8	-2.0	-1.8
Neuroticism	1.8	4.4	11.4	-1.5	-1.0	-3.4	-2.0	-1.9	-2.1	-2.2	-2.1	-1.3	-1.9	-2.8	-2.1	-1.8
Townsend deprivation index at recruitment	1.8	2.5	6.1	0.4	-0.5	-2.5	-1.6	-1.3	-1.6	-1.4	-1.6	-1.4	-1.7	-2.1	-1.6	-1.6
Medication: Ramipril	1.8	2.3	6.6	-1.8	-2.0	-0.2	-1.4	-1.9	-1.4	-1.2	-1.4	-0.1	-0.5	-2.6	-1.4	-1.6
Medication: Paracetamol	1.8	3.0	6.6	-2.6	-0.9	-2.5	-1.6	-1.4	-1.6	-1.0	-1.6	-0.8	-1.9	-2.2	-1.6	-1.5
Asthma (self-reported)	1.8	3.5	5.5	1.9	2.4	0.8	2.1	2.1	2.0	1.1	2.0	1.5	1.6	2.1	2.0	2.2
Pack years of smoking	1.8	2.6	3.5	0.1	-0.8	-1.9	-1.8	-1.7	-1.8	-1.6	-1.8	-1.6	-1.7	-1.6	-1.8	-1.7
LDL Cholesterol	1.7	2.7	6.3	-1.7	0.7	0.7	1.5	1.7	1.9	2.5	1.9	1.4	1.3	1.7	1.9	1.4
Average weekly spirits intake	1.7	2.1	3.1	0.7	1.0	0.5	1.6	1.7	1.6	1.2	1.6	1.6	1.4	1.6	1.6	1.8
Vitamin and mineral supplements	1.7	2.3	6.1	0.9	0.9	2.5	1.5	1.3	1.6	0.6	1.5	1.8	1.8	1.2	1.5	1.7
Asthma	1.7	3.3	5.4	1.9	2.3	0.8	2.0	2.0	1.9	1.1	1.9	1.4	1.5	2.0	1.9	2.1
Mean Putamen Volume	1.6	1.8	2.9	-0.0	-1.7	-0.7	-1.5	-1.3	-1.6	-0.9	-1.7	-1.1	-1.5	-1.6	-1.7	-1.3
Pack years adult smoking proportion	1.6	2.5	3.4	-0.2	-1.0	-1.9	-1.7	-1.6	-1.8	-1.5	-1.8	-1.6	-1.7	-1.4	-1.8	-1.7
Medication: Levothyroxine sodium	1.6	2.7	4.6	0.4	-1.3	-1.8	-1.7	-2.0	-1.7	-2.2	-1.6	-1.6	-1.1	-1.7	-1.6	-1.8
Sitting height	1.6	11.2	22.8	-0.9	3.0	3.8	3.3	4.0	3.4	4.8	3.5	2.2	1.8	4.1	3.5	3.2
High blood pressure (mother)	1.6	2.2	8.3	-2.9	-0.8	0.3	1.1	1.1	1.3	2.5	1.4	1.8	1.5	0.3	1.4	0.9
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	7.0	0.9	-1.9	-1.4	-1.8	-2.3	-1.7	-2.7	-1.7	-1.7	-0.8	-1.6	-1.7	-2.0
Commuting to job workplace: Walk	1.6	1.8	4.4	1.5	2.1	1.4	1.2	0.9	1.1	0.9	1.0	0.8	1.7	1.8	1.0	1.1
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	7.3	1.5	0.7	2.7	1.0	0.9	1.0	1.5	1.1	0.5	1.2	1.6	1.1	0.7
Father’s age at death	1.5	2.0	4.0	1.0	0.3	-0.9	-1.5	-1.5	-1.6	-2.0	-1.6	-1.8	-1.5	-1.2	-1.6	-1.4
Pulse wave peak to peak time	1.5	1.8	5.9	-1.9	0.4	0.4	1.2	1.7	1.3	2.4	1.3	0.8	0.3	1.3	1.3	1.2
Number of full sisters	1.5	1.9	2.7	0.0	-0.0	1.6	1.5	1.6	1.5	1.6	1.5	1.5	1.3	1.1	1.5	1.5
Cholesterol lowering medication	1.5	2.2	4.1	0.7	-0.2	-1.0	-1.6	-2.0	-1.7	-1.4	-1.7	-1.3	-0.7	-2.0	-1.7	-1.8
Depressed Affect (Nagel 2018)	1.4	2.9	5.9	-1.2	-0.3	-2.4	-1.8	-1.6	-1.8	-1.6	-1.7	-1.3	-1.9	-2.4	-1.7	-1.6
Happiness	1.4	1.7	3.1	-1.1	-1.2	-1.4	-1.3	-0.9	-1.4	-1.0	-1.4	-1.2	-1.8	-1.3	-1.4	-1.2
Ever had bowel cancer screening	1.4	1.6	2.9	-0.2	-1.4	-1.2	-1.3	-1.2	-1.4	-1.0	-1.4	-1.3	-1.1	-1.7	-1.4	-1.4
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.1	-0.3	-0.8	-0.9	-1.4	-1.4	-1.5	-1.5	-1.5	-1.2	-1.3	-1.8	-1.5	-1.4
Ever depressed for a whole week	1.4	1.8	3.3	0.4	0.3	1.8	1.4	1.4	1.5	1.0	1.5	1.1	1.1	1.7	1.5	1.5
Alcohol drinker status: Previous	1.4	1.6	5.7	-0.5	0.3	-2.4	-1.1	-1.2	-1.1	-1.4	-1.1	-0.6	-0.9	-1.9	-1.1	-1.3
Bipolar Disorder (2018)	1.3	2.1	8.2	0.7	0.5	-0.8	-1.4	-1.8	-1.5	-2.9	-1.5	-1.1	-0.5	-1.6	-1.5	-1.2
Medication for pain relief, constipation, heartburn	1.3	2.2	14.4	3.8	0.8	1.8	1.0	0.9	0.9	0.0	0.9	-0.1	1.0	2.0	0.9	1.1
Heart disease (mother)	1.3	1.6	3.4	0.0	1.9	1.3	1.2	1.1	1.4	1.4	1.4	1.3	1.7	0.7	1.4	0.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.4	-0.9	-0.8	-1.0	-1.3	-1.3	-1.3	-0.4	-1.2	-1.3	-1.0	-1.6	-1.2	-1.5
Average weekly fortified wine intake	1.2	1.4	3.5	1.1	1.3	0.9	1.3	0.8	1.2	0.3	1.2	1.0	1.9	1.2	1.2	1.2
Nervous feelings	1.2	2.2	6.1	-1.3	-0.7	-2.5	-1.3	-1.5	-1.6	-0.7	-1.6	-0.8	-0.9	-2.1	-1.6	-1.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.0	-0.3	-0.6	-0.6	-1.3	-1.3	-1.4	-1.3	-1.4	-1.2	-1.4	-1.2	-1.4	-1.3
Supplements: Vitamin C	1.2	1.5	3.8	1.0	-0.6	-1.6	-1.2	-1.0	-1.3	-0.7	-1.2	-2.0	-1.3	-0.6	-1.2	-1.3
Basal cell carcinoma (self-reported)	1.2	1.4	2.8	-0.3	-1.7	-0.1	-1.2	-1.1	-1.3	-1.0	-1.3	-0.9	-1.4	-1.6	-1.3	-1.2
HDL Cholesterol	1.1	1.8	3.8	1.7	1.5	1.2	1.1	1.4	1.3	0.9	1.3	0.7	1.1	1.9	1.3	1.4
Rheumatoid Arthritis	1.1	1.5	3.8	1.0	-1.5	-0.5	-1.2	-1.4	-1.2	-2.0	-1.2	-0.8	-0.8	-1.2	-1.2	-1.0
Smoking Status	1.1	2.6	7.6	0.8	2.8	0.6	1.7	1.6	1.6	1.6	1.6	1.2	1.8	1.7	1.6	1.5
Pulse wave Arterial Stiffness index	1.1	1.3	4.2	1.7	-0.2	-0.1	-1.0	-1.5	-1.1	-2.1	-1.1	-0.7	-0.3	-1.0	-1.1	-1.1
Alcohol intake frequency.	1.1	2.5	8.1	-2.7	-0.2	-2.9	-1.0	-0.5	-1.0	-1.1	-1.1	0.1	-2.0	-2.6	-1.1	-0.7
Knee pain experienced in last month	1.1	1.7	2.5	-0.1	-1.6	-0.8	-1.4	-1.3	-1.4	-1.2	-1.5	-1.1	-1.6	-1.4	-1.5	-1.4
Illnesses of father: Heart disease	1.1	1.5	8.8	1.7	3.0	0.9	0.8	0.4	0.7	0.5	0.7	0.4	1.8	0.9	0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.8	-1.0	-1.0	-0.9	-1.2	-0.7	-1.2	0.1	-1.1	-1.7	-1.6	-0.6	-1.1	-1.3
Commuting to job workplace: Public transport	1.1	1.3	4.0	1.9	1.5	1.2	1.0	0.4	0.9	0.1	0.9	0.7	2.0	0.9	0.9	0.8
Eye problems/disorders: Glaucoma	1.1	1.3	4.1	-2.0	0.3	1.1	1.0	0.9	1.0	1.8	1.1	1.3	0.8	0.8	1.1	0.9
Pain experienced in last month	1.1	1.8	5.6	0.7	2.4	1.3	1.2	1.2	1.3	1.5	1.2	1.1	1.6	1.1	1.2	1.1
Current tobacco smoking	1.0	1.6	4.8	0.9	2.2	0.8	1.2	1.2	1.2	1.6	1.2	0.8	1.1	1.4	1.2	1.0
Stomach or abdominal pain in last month	1.0	1.2	8.4	-2.9	0.4	-0.6	0.4	0.9	0.4	2.3	0.4	0.4	-0.3	0.4	0.4	0.4
Illnesses of mother	1.0	1.2	2.8	1.1	-0.7	-0.3	-1.0	-1.0	-1.2	-1.4	-1.2	-1.7	-1.4	-0.2	-1.2	-0.9
Hand grip strength (left)	0.9	2.4	4.2	-1.4	1.3	1.6	1.5	1.6	1.5	2.0	1.5	1.6	1.3	1.5	1.5	1.4
Ever had hysterectomy (womb removed)	0.9	1.0	6.6	1.9	0.4	2.6	0.5	0.4	0.5	0.4	0.5	-0.0	0.7	0.9	0.5	0.4
Severe depression (siblings)	0.9	1.1	2.0	-1.4	0.6	1.3	0.9	1.1	1.0	1.4	1.1	0.9	0.5	1.1	1.1	0.8
Leg fat-free mass (left)	0.9	4.5	7.9	-1.3	2.4	1.8	2.1	2.5	2.2	2.8	2.2	1.8	1.1	2.4	2.2	2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.7	-1.3	-2.4	-0.7	-1.5	-1.2	-1.4	-0.9	-1.5	-0.9	-1.5	-1.5	-1.5	-1.2
Trunk fat-free mass	0.9	5.3	13.2	-1.6	2.6	1.8	2.2	2.7	2.2	3.6	2.2	1.5	1.1	2.9	2.2	2.1
Trunk predicted mass	0.9	5.3	13.2	-1.6	2.6	1.8	2.2	2.7	2.2	3.6	2.2	1.5	1.1	2.9	2.2	2.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	-1.6	-0.7	-0.6	-1.1	-0.8	-1.1	-0.3	-1.1	-0.6	-1.2	-1.3	-1.1	-0.9
Arm predicted mass (right)	0.9	4.6	11.4	-1.6	2.4	1.6	2.0	2.6	2.1	3.4	2.1	1.5	0.9	2.5	2.1	2.0
Whole body fat-free mass	0.9	5.2	12.0	-1.6	2.6	1.8	2.2	2.7	2.2	3.5	2.2	1.7	1.1	2.7	2.2	2.1
Leg fat-free mass (right)	0.9	4.6	8.4	-1.4	2.4	1.9	2.1	2.6	2.2	2.9	2.2	1.8	1.1	2.5	2.2	2.2
Loneliness, isolation	0.9	1.2	2.9	0.1	1.5	-1.7	-1.0	-0.6	-1.0	-1.0	-1.0	-1.2	-1.5	-0.9	-1.0	-0.8
Schizophrenia (2018)	0.8	1.6	5.2	0.7	-0.8	-1.4	-1.9	-2.3	0.0	0.0	0.0	0.0	-1.8	-2.3	0.0	0.0
Age at First Birth	0.8	1.2	2.0	-0.2	0.9	-0.7	1.2	1.2	1.3	0.8	1.3	1.4	1.1	0.7	1.3	1.2
Blood White Count	0.8	5.8	11.2	-2.1	-2.7	-2.1	-2.5	-2.8	-2.4	-2.0	-2.4	-1.2	-1.8	-3.3	-2.4	-2.7
Diabetes (mother)	0.8	1.0	2.4	1.0	0.8	1.0	1.0	0.7	1.1	0.2	1.1	1.1	1.6	1.0	1.1	0.9
Leg predicted mass (left)	0.8	4.4	7.9	-1.3	2.4	1.7	2.1	2.5	2.2	2.8	2.2	1.8	1.1	2.4	2.2	2.1
Number of incorrect matches in round	0.8	1.3	2.8	1.1	-0.4	-1.3	-0.9	-1.5	-1.1	-1.7	-1.2	-0.5	0.2	-1.5	-1.2	-1.0
Alcohol usually taken with meals	0.8	1.3	5.2	-0.0	-2.3	0.6	-1.2	-1.4	-1.1	-0.6	-1.1	-0.7	-0.3	-1.3	-1.1	-1.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.7	1.6	0.7	1.3	0.9	0.8	0.9	0.2	0.8	0.5	0.8	1.3	0.8	1.0
Pulse rate	0.8	1.4	2.7	-0.2	1.3	-0.3	1.3	1.3	1.3	1.2	1.3	1.6	1.3	0.6	1.3	1.3
Breastfed as a baby	0.8	1.0	2.9	0.3	0.7	0.9	0.9	1.1	0.9	1.7	1.0	0.1	0.8	1.5	1.0	0.7
Arm fat-free mass (right)	0.8	4.1	10.3	-1.4	2.3	1.6	1.9	2.5	2.0	3.2	2.0	1.4	0.9	2.5	2.0	1.8
Smoking status: Current	0.8	1.3	5.0	0.8	2.2	0.6	1.1	1.1	1.0	1.5	1.1	0.6	1.0	1.3	1.1	0.8
Whole body water mass	0.8	4.7	11.0	-1.5	2.5	1.7	2.1	2.6	2.1	3.3	2.1	1.5	0.9	2.6	2.1	2.0
Leg predicted mass (right)	0.8	4.4	8.1	-1.4	2.3	1.9	2.0	2.5	2.1	2.9	2.1	1.7	1.0	2.4	2.1	2.1
Basal metabolic rate	0.8	4.2	9.6	-1.9	2.4	1.4	1.9	2.4	2.0	3.1	2.0	1.6	0.8	2.3	2.0	1.9
Coronary Artery Disease (CAD)	0.7	0.8	1.8	0.2	-1.4	-1.0	-0.8	-1.0	-1.2	-1.2	-0.8	-0.7	-0.3	-1.0	-0.8	-0.7
Hearing difficulty/problems: Yes	0.7	1.1	3.0	0.8	-1.0	-0.6	-1.0	-1.4	-1.0	-1.7	-1.0	-0.9	-0.1	-1.1	-1.0	-1.1
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.4	0.2	-1.0	-1.6	-0.9	-1.2	-0.9	-1.2	-0.9	-0.5	-0.4	-1.3	-0.9	-1.0
Financial difficulties in last 2 years	0.7	1.0	2.9	0.0	1.7	-0.5	1.0	1.4	1.1	0.7	1.1	1.0	0.2	0.8	1.1	1.0
Length of working week for main job	0.7	0.8	4.1	-2.0	-1.6	-0.7	-0.5	-0.6	-0.4	-0.2	-0.4	0.1	-0.5	-1.1	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	6.5	-1.4	-0.1	-2.5	-0.6	-0.4	-0.7	-0.8	-0.7	-0.0	-1.0	-1.4	-0.7	-0.4
Loud music exposure frequency	0.7	0.7	2.1	0.1	0.8	-0.4	0.9	1.0	0.9	1.4	0.9	0.7	0.5	0.8	0.9	0.9
Health satisfaction	0.7	1.0	3.0	-0.4	-0.3	0.6	1.1	1.0	1.0	0.9	1.0	1.7	1.2	0.4	1.0	1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	5.3	2.3	0.7	-0.7	-0.3	-0.6	-0.5	-1.5	-0.5	-0.6	-0.2	-0.2	-0.5	-0.4
Medication: Blood pressure	0.7	1.3	5.8	-1.9	-1.5	-0.3	-0.7	-1.2	-0.7	-0.9	-0.7	0.9	0.3	-2.4	-0.7	-0.7
Migraine (self-reported)	0.7	0.8	2.2	-0.5	-0.4	-0.2	1.1	1.0	1.1	-0.0	1.1	1.5	0.8	0.6	1.1	1.3
Age at last live birth	0.7	1.1	3.6	-0.7	-0.5	-1.1	-1.1	-0.4	-1.0	0.4	-0.9	-1.7	-1.9	-0.3	-0.9	-1.2
Medication: Aspirin	0.7	0.9	2.7	-1.2	0.2	-0.8	-0.9	-1.4	-0.9	-0.9	-0.9	-0.2	0.1	-1.6	-0.9	-1.2
Unable to work because of sickness or disability	0.7	0.9	2.5	0.5	1.6	-0.8	1.0	0.8	1.0	0.1	1.0	1.0	1.0	0.7	1.0	0.9
Commuting to job workplace: Cycle	0.7	0.9	1.5	0.4	-0.8	1.0	0.9	0.7	0.9	1.0	1.0	0.9	1.2	1.2	1.0	1.0
Supplements: Calcium	0.7	0.8	2.6	1.2	0.8	-1.6	-0.6	-0.5	-0.7	-1.0	-0.8	-1.2	-0.8	-0.1	-0.8	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	0.7	-1.1	-0.7	-0.7	-0.4	-0.8	-0.8	-0.8	-1.2	-1.4	-0.0	-0.8	-0.5
Neuroticism (2016)	0.6	0.9	5.3	-0.4	0.1	-2.3	-1.0	-1.3	0.0	0.0	0.0	0.0	-0.8	-1.7	0.0	0.0
Had other major operations	0.6	0.8	1.7	0.9	1.3	0.0	-0.9	-0.8	-1.0	-0.9	-0.9	-1.1	-0.6	-0.5	-0.9	-0.8
Neuroticism score	0.6	1.3	7.1	-1.2	-0.1	-2.7	-0.8	-0.8	-0.9	-1.1	-0.9	-0.2	-0.6	-1.7	-0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	6.2	-1.2	-0.1	-2.5	-0.5	-0.2	-0.5	-0.6	-0.5	-0.2	-1.2	-1.2	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.2	-0.8	0.6	1.9	1.2	1.7	1.3	2.3	1.3	0.7	0.7	1.9	1.3	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	4.5	-1.4	0.2	-2.1	-0.5	-0.4	-0.4	0.1	-0.4	-0.2	-0.6	-0.6	-0.4	-0.5
Lung cancer (father)	0.6	0.7	1.9	-1.3	-0.3	-0.5	0.8	0.9	0.9	0.3	0.9	1.4	0.3	0.1	0.9	1.0
Standing height	0.6	5.6	13.6	-0.5	3.1	2.9	2.0	2.8	2.0	3.7	2.0	0.6	0.8	3.5	2.0	1.9
Tense / ‘highly strung’	0.6	1.0	3.8	-1.0	-0.2	-1.9	-0.9	-0.8	-1.0	-0.1	-1.0	-0.8	-1.1	-1.0	-1.0	-0.7
Gout (self-reported)	0.6	0.9	1.5	-0.2	0.8	-0.5	-1.1	-0.7	-1.1	0.2	-1.0	-1.2	-1.1	-1.2	-1.0	-1.0
Comparative body size at age 10	0.6	1.7	3.2	-1.8	-1.4	-1.1	-1.2	-1.3	-1.1	-1.3	-1.1	-0.6	-1.3	-1.8	-1.1	-1.2
Medication: Ibuprofen	0.6	0.7	7.2	-2.7	-0.1	-0.9	-0.3	-0.1	-0.3	0.3	-0.4	0.3	-0.6	-0.5	-0.4	-0.2
Mean time to correctly identify matches	0.6	1.1	4.9	2.2	-1.2	1.0	-0.8	-1.1	-0.8	-1.2	-0.7	-1.1	-0.1	0.1	-0.7	-1.0
Chest pain or discomfort	0.6	0.9	1.6	-0.6	0.3	-0.8	-1.0	-0.9	-1.0	-0.9	-1.1	-0.9	-1.0	-1.2	-1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.5	-0.9	0.7	1.1	0.5	0.7	0.5	1.6	0.6	-0.1	0.5	1.3	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	-1.5	-1.3	-1.0	-1.0	-0.7	-0.9	-0.4	-0.9	-0.6	-1.2	-1.1	-0.9	-0.8
Back pain experienced in last month	0.6	0.9	2.0	0.1	-1.1	-0.9	-0.9	-1.0	-1.0	-0.9	-1.0	-0.6	-0.6	-1.4	-1.0	-1.0
Medication: Aspirin	0.6	0.8	2.4	-1.3	0.3	-0.6	-0.8	-1.2	-0.8	-0.4	-0.7	-0.1	0.0	-1.6	-0.7	-1.1
Ever smoked	0.6	1.0	2.0	0.7	1.4	-0.7	1.1	1.1	1.0	0.8	0.9	0.8	1.0	1.0	0.9	1.1
Arm fat-free mass (left)	0.6	3.1	8.5	-1.7	2.2	1.0	1.6	2.0	1.6	2.9	1.6	1.2	0.7	2.0	1.6	1.5
Arm predicted mass (left)	0.6	3.0	8.7	-1.7	2.2	1.0	1.5	2.1	1.6	3.0	1.6	1.1	0.5	2.0	1.6	1.5
Major Depression (MDD)	0.5	0.6	1.7	0.0	-0.8	-0.4	-0.7	-0.5	-0.8	-1.2	-0.9	-0.7	-1.3	-0.5	-0.9	-0.4
Ovarian Cancer	0.5	0.7	3.9	-0.4	-2.0	0.9	-0.6	-0.9	-0.6	-1.0	-0.6	-0.5	-0.1	-0.6	-0.6	-0.7
Fasting Glucose	0.5	0.6	3.0	-1.7	0.5	0.3	0.2	0.6	0.2	1.2	0.6	0.8	0.3	-0.7	0.6	0.3
Number of treatments/medications taken	0.5	0.8	3.8	-1.6	-0.3	-1.2	-0.3	-0.8	-0.5	-0.5	-0.5	0.8	0.3	-2.0	-0.5	-0.5
Angina	0.5	0.6	4.6	0.8	2.1	0.4	0.3	-0.3	0.2	-0.5	0.2	0.3	1.3	-0.1	0.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	0.6	-1.1	0.4	0.8	0.7	0.8	0.5	0.8	0.5	1.0	0.7	0.8	0.7
Multivitamins +/- minerals	0.5	0.6	2.9	-1.7	-1.2	-1.0	-0.5	-0.4	-0.5	0.3	-0.5	-0.5	-0.8	-0.5	-0.5	-0.7
Allergy	0.5	1.2	2.7	0.7	-1.3	-0.1	-1.1	-1.6	-1.1	-1.6	-1.0	-1.1	-0.2	-0.9	-1.0	-1.3
Pain all over the body in last month	0.5	0.5	4.4	-0.9	-2.1	-0.2	0.4	0.2	0.4	-0.2	0.4	0.7	0.2	0.3	0.4	0.4
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	-1.3	-0.5	1.3	0.7	1.1	0.7	1.3	0.7	0.9	0.0	0.6	0.7	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	0.8	0.2	0.5	1.0	0.7	0.9	0.2	0.9	0.7	1.2	0.5	0.9	0.9
Qualifications: College or University degree	0.5	1.7	2.9	-1.5	-0.9	0.8	-1.5	-1.7	-1.5	-0.5	-1.4	-1.6	-1.2	-0.6	-1.4	-1.7
Angina (self-reported)	0.5	0.6	5.4	0.8	2.3	0.4	0.2	-0.3	0.2	-0.4	0.2	0.2	1.2	-0.1	0.2	0.0
Medication: Gliclazide	0.5	0.5	1.0	0.8	0.3	-0.7	-0.7	-1.0	-0.7	-1.0	-0.6	-0.9	-0.1	-0.7	-0.6	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	3.8	-1.9	-1.3	-0.8	0.1	0.5	0.2	0.7	0.2	0.4	-0.8	-0.1	0.2	0.2
Average weekly champagne plus white wine intake	0.5	0.7	2.3	-1.4	-0.6	-0.1	-0.8	-0.1	-0.6	0.8	-0.6	-1.1	-1.5	-0.4	-0.6	-0.8
Irritability	0.5	0.8	4.5	-2.1	-1.0	-1.8	-0.2	-0.0	-0.2	0.6	-0.2	0.3	-0.6	-0.9	-0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	3.1	-1.8	-0.3	-1.1	-0.6	-0.1	-0.5	1.1	-0.4	-0.6	-0.7	-0.8	-0.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.7	1.0	0.9	1.3	-0.9	-0.8	-0.8	-0.4	-0.8	-1.6	-0.4	0.5	-0.8	-0.9
Body Mass Index (BMI) (2010)	0.4	0.6	1.8	-1.2	-0.1	-1.4	-0.6	-0.4	-0.6	-0.5	-0.6	-0.3	-1.0	-1.1	-0.6	-0.5
Lupus	0.4	0.6	1.2	0.5	0.1	0.8	0.9	0.6	0.8	0.0	0.8	0.5	1.1	0.9	0.8	1.1
Schizophrenia (2014)	0.4	0.8	3.2	1.8	0.2	-0.8	-1.3	-1.6	0.0	0.0	0.0	0.0	-1.1	-1.0	0.0	0.0
Height	0.4	7.3	16.5	1.2	4.1	3.6	2.1	3.1	2.2	3.9	2.3	0.1	0.6	3.9	2.3	1.9
Medication: Metformin	0.4	0.6	1.7	0.0	-0.5	-1.3	-0.6	-0.9	-0.6	-1.3	-0.6	-0.4	-0.1	-1.2	-0.6	-0.7
Serious illness, injury or assault to yourself	0.4	0.4	2.2	0.2	-0.4	-1.5	-0.4	-0.6	-0.4	-0.9	-0.4	0.1	-0.1	-1.2	-0.4	-0.4
Past tobacco smoking	0.4	0.7	2.4	-0.8	-1.6	1.1	-0.9	-0.7	-0.7	-0.2	-0.6	-0.7	-1.1	-0.4	-0.6	-0.9
Qualifications: None of the above	0.4	0.8	5.5	2.4	0.7	-1.4	0.2	0.1	0.1	-1.3	0.1	0.2	0.2	-0.2	0.1	0.4
Medication: Simvastatin	0.4	0.5	2.2	-0.5	-0.3	-0.5	-0.5	-1.1	-0.7	-0.5	-0.7	0.2	0.6	-1.5	-0.7	-0.9
Fluid intelligence score	0.4	0.9	3.1	1.3	1.8	1.1	-0.6	-0.6	-0.5	-0.3	-0.5	-1.5	-0.1	0.8	-0.5	-0.7
Alcohol intake versus 10 years previously	0.4	0.5	3.1	-1.8	0.4	-1.0	0.2	0.6	0.2	0.4	0.1	0.9	-0.3	-1.1	0.1	0.4
Number of live births	0.4	0.6	4.3	2.1	1.2	0.2	-0.1	-0.4	-0.2	-1.0	-0.2	-0.5	0.2	0.1	-0.2	-0.2
Mouth/teeth dental problems: Dentures	0.4	0.6	3.1	1.8	0.3	-0.9	-0.6	-0.4	-0.6	-0.4	-0.7	-1.1	-0.6	-0.2	-0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	4.7	-2.2	0.4	-1.0	-0.3	-0.1	-0.3	0.3	-0.3	0.0	-0.6	-0.3	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	6.0	-0.7	-0.0	1.6	0.8	1.4	0.9	2.5	1.0	0.0	0.3	1.7	1.0	0.8
Birth weight of first child	0.4	0.8	2.5	1.4	1.6	1.3	0.4	0.6	0.4	0.5	0.5	-0.6	0.1	1.4	0.5	0.4
Medication: Amlodipine	0.4	0.6	2.5	-0.3	-0.3	1.0	0.7	0.1	0.7	0.2	0.7	1.4	1.6	-0.1	0.7	0.4
High blood pressure (siblings)	0.4	0.5	2.7	-1.0	-1.6	-0.6	-0.3	-0.7	-0.3	-0.5	-0.4	0.5	0.3	-1.0	-0.4	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.4	-0.6	-0.7	-1.0	-0.5	-0.6	-0.6	-1.2	-0.6	-0.0	-0.6	-1.2	-0.6	-0.3
Eye problems/disorders: None of the above	0.4	0.5	1.4	1.0	-0.4	-0.8	-0.5	-0.8	-0.5	-1.2	-0.6	-0.3	0.0	-1.1	-0.6	-0.6
Medication: Allopurinol	0.4	0.6	1.4	0.9	0.7	-0.3	-0.8	-0.6	-0.8	-0.2	-0.7	-1.2	-0.7	-0.6	-0.7	-0.9
Medication: Omeprazole	0.4	0.5	3.4	-1.3	0.1	-0.5	0.1	0.6	0.2	1.9	0.3	0.1	-0.1	-0.2	0.3	-0.1
Medication: Seretide 50 evohaler	0.4	0.4	1.7	1.3	0.1	-0.3	-0.5	-0.8	-0.5	-1.1	-0.5	-0.6	-0.1	-0.4	-0.5	-0.6
Pulse rate, automated reading	0.4	1.2	5.0	1.5	0.1	-2.2	-0.6	-0.8	-0.7	-1.9	-0.8	-0.5	-0.6	-0.8	-0.8	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.6	-1.6	-0.6	-0.9	-0.1	0.4	0.0	0.9	0.1	-0.1	-1.1	0.0	0.1	-0.1
Mood swings	0.4	0.8	2.9	-1.6	-0.2	-1.7	-0.4	-0.4	-0.4	-0.1	-0.4	0.5	-0.3	-1.7	-0.4	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.4	1.1	0.4	-1.2	-0.5	-0.6	-0.6	-0.5	-0.6	-0.8	-0.5	-0.5	-0.6	-0.6
Osteoarthritis (self-reported)	0.4	0.5	2.0	0.0	-0.1	-1.4	-0.6	-0.7	-0.7	-0.6	-0.7	-0.6	-0.6	-0.5	-0.7	-0.6
Guilty feelings	0.4	0.6	3.6	-1.6	0.7	-1.9	-0.3	0.1	-0.3	0.3	-0.3	-0.0	-0.5	-0.5	-0.3	-0.1
Medication: Blood pressure	0.4	0.7	2.2	0.5	-1.1	0.3	-0.5	-1.2	-0.6	-1.4	-0.7	0.3	0.6	-1.5	-0.7	-0.7
Average weekly beer plus cider intake	0.4	0.6	1.6	-1.3	1.3	0.1	0.6	0.7	0.6	1.0	0.6	0.3	0.1	0.9	0.6	0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.4	0.2	1.2	1.1	0.3	0.3	0.4	1.2	0.4	-0.2	0.7	0.9	0.4	0.1
Depression (Nagel 2018)	0.3	0.4	1.8	-0.2	0.7	-1.3	-0.5	-0.2	-0.4	-0.9	-0.4	-0.5	-1.0	-0.4	-0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.1	1.6	1.2	0.8	-0.9	-0.7	-0.7	-0.5	-0.8	-1.8	-0.5	0.5	-0.8	-1.0
Reaction Time	0.3	0.5	2.4	1.5	-0.3	1.5	0.2	-0.2	0.3	-0.4	0.3	0.1	1.0	0.8	0.3	0.1
Breast Cancer	0.3	0.8	1.8	0.4	0.1	0.0	-1.0	-1.1	-1.0	-1.1	-1.0	-1.2	-0.6	-0.8	-1.0	-1.4
Prostate Cancer	0.3	0.5	0.8	-0.1	0.4	0.4	0.8	0.8	0.8	0.9	0.9	0.9	0.8	0.2	0.9	0.3
Primary Biliary Cirrhosis	0.3	0.5	2.2	1.2	0.2	-0.9	-0.4	-0.6	-0.4	-1.5	-0.4	-0.3	-0.3	-0.6	-0.4	-0.3
Triglycerides	0.3	0.4	3.1	-0.7	-1.8	-0.8	-0.1	-0.1	0.1	0.7	-0.1	0.3	0.0	-0.7	-0.1	-0.3
Blood Red Count	0.3	3.3	7.5	1.8	-2.3	-1.1	-1.7	-1.6	-1.7	-2.7	-1.8	-2.0	-1.6	-1.3	-1.8	-1.6
BMI	0.3	1.5	6.7	-2.6	1.0	0.2	0.9	1.1	1.1	1.2	1.2	1.6	0.6	0.4	1.2	1.0
Chronotype (morning person)	0.3	0.7	2.8	-0.3	-0.5	1.3	0.3	-0.4	0.2	-0.3	0.1	1.7	1.7	-1.0	0.1	0.4
Tanning	0.3	3.3	5.0	-1.3	-2.0	-0.7	-2.1	-2.2	-2.0	-1.1	-1.9	-1.7	-1.4	-2.2	-1.9	-2.2
Sensitivity / hurt feelings	0.3	0.5	3.8	-1.0	-0.5	-1.9	0.3	0.1	0.2	-0.2	0.1	0.9	0.6	-0.7	0.1	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.6	-0.1	1.6	-1.4	0.2	0.3	0.1	-0.3	0.1	0.1	-0.1	0.1	0.1	0.3
Medication for hormone replacement therapy	0.3	0.4	1.2	-0.3	-0.1	-0.8	-0.6	-0.2	-0.6	0.6	-0.5	-1.0	-1.1	-0.1	-0.5	-0.7
Diabetes (father)	0.3	0.4	2.0	-0.7	-1.4	-0.4	-0.3	-0.3	-0.3	-0.2	-0.2	0.4	-0.1	-1.2	-0.2	-0.3
Hand grip strength (right)	0.3	0.9	2.2	-1.1	0.7	0.8	0.8	1.0	0.8	1.5	0.8	0.9	0.7	0.9	0.8	0.9
Fed-up feelings	0.3	0.5	2.8	-1.7	0.3	-1.3	-0.2	-0.2	-0.3	-0.5	-0.4	0.5	-0.5	-1.1	-0.4	-0.1
Age when periods started (menarche)	0.3	0.6	1.4	-0.8	-0.3	-0.8	-0.9	-0.4	-0.9	0.1	-0.8	-0.8	-1.1	-1.2	-0.8	-0.9
Supplements: Glucosamine	0.3	0.3	1.9	-1.4	-0.2	-1.0	0.0	0.2	-0.0	0.9	-0.0	-0.2	-0.5	0.4	-0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	4.0	-2.0	-0.1	0.5	0.1	0.4	0.1	0.8	0.2	-0.0	-0.5	0.1	0.2	0.1
Weight	0.3	1.3	5.2	-2.3	1.5	0.5	0.8	1.1	0.9	1.6	0.9	1.1	0.1	0.7	0.9	0.8
Time employed in main current job	0.3	0.3	2.8	1.7	-0.4	0.4	-0.0	-0.2	0.0	-0.4	0.0	-0.5	0.3	0.6	0.0	-0.2
Falls in the last year	0.3	0.4	1.8	-1.3	1.1	-1.4	-0.2	-0.2	-0.1	-0.2	-0.0	0.3	-0.0	-0.8	-0.0	-0.2
Depression (self-reported)	0.3	0.4	2.3	1.5	0.3	-1.0	-0.2	-0.2	-0.2	-0.9	-0.1	-0.3	0.0	-0.5	-0.1	-0.1
Medication: Lansoprazole	0.3	0.4	0.8	-0.6	0.9	0.8	0.5	0.5	0.4	0.8	0.4	0.5	0.7	0.4	0.4	0.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	-1.2	-0.8	-1.4	-0.8	-0.7	-0.7	-0.4	-0.6	-1.2	-1.1	-0.3	-0.6	-0.9
Blood clot in the leg (DVT)	0.3	0.3	3.6	-0.7	-1.9	0.4	-0.2	0.1	0.1	-0.1	0.1	-0.0	-0.2	-0.2	0.1	-0.2
Headache pain in last month	0.3	0.5	3.3	-1.8	-1.1	-1.0	-0.2	0.0	-0.3	-0.3	-0.3	0.3	-0.6	-0.7	-0.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.8	0.3	-0.1	0.2	0.4	1.0	0.4	0.7	0.4	-0.7	-1.0	1.7	0.4	0.6
Glaucoma (self-reported)	0.3	0.4	2.8	-1.7	-0.4	0.2	0.2	0.1	0.2	0.8	0.3	0.6	0.4	-0.2	0.3	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.6	0.9	0.1	0.8	0.7	0.6	0.4	0.6	0.6	0.6	0.6	0.6	0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	4.8	-0.7	0.5	1.4	0.7	1.3	0.8	2.2	0.9	-0.2	0.1	1.7	0.9	0.7
Leg fat percentage (right)	0.3	0.9	2.9	-1.6	-0.4	-1.1	-0.8	-1.0	-0.7	-1.0	-0.8	0.2	-0.6	-1.7	-0.8	-0.8
Worry too long after embarrassment	0.3	0.4	1.9	-0.5	1.1	-1.4	0.5	0.2	0.4	-0.1	0.4	0.5	0.9	0.2	0.4	0.6
Neck or shoulder pain in last month	0.3	0.4	1.2	-0.8	-0.3	-0.9	-0.5	-0.3	-0.6	-0.4	-0.6	-0.7	-1.1	-0.4	-0.6	-0.3
Comparative height size at age 10	0.3	1.4	3.5	0.5	1.2	1.2	1.1	1.5	1.1	1.6	1.1	0.3	0.4	1.9	1.1	1.1
Family relationship satisfaction	0.3	0.4	2.0	0.5	0.2	1.4	0.5	0.6	0.4	1.0	0.3	0.4	0.4	0.8	0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.8	1.0	-0.7	1.3	-0.1	-0.5	-0.2	-0.5	-0.3	-0.2	0.3	-0.2	-0.3	-0.1
Average weekly red wine intake	0.3	0.5	3.6	0.3	-1.9	0.8	-0.4	-0.6	-0.5	0.4	-0.5	-0.1	0.3	-0.4	-0.5	-0.5
Friendships satisfaction	0.3	0.4	2.4	-1.2	-1.5	0.1	-0.2	0.1	-0.3	0.3	-0.3	0.2	-0.7	-0.3	-0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.4	-1.2	-0.6	-0.7	-0.2	0.0	-0.2	0.5	-0.2	0.0	-0.6	-0.9	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.2	-0.1	-1.8	1.2	-0.8	-0.4	-0.6	0.6	-0.5	-1.2	-0.6	0.1	-0.5	-0.9
Number of operations (self-reported)	0.3	0.4	1.1	-0.1	-1.0	0.8	-0.7	-0.6	-0.7	-0.2	-0.8	-0.6	-0.4	-0.5	-0.8	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.4	0.4	-1.2	-0.4	-0.6	-0.4	-0.2	-0.4	0.1	0.1	-1.2	-0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	4.0	-0.7	-2.0	0.5	0.1	0.3	0.3	0.1	0.3	0.3	-0.0	-0.2	0.3	-0.0
Heel T-Score	0.2	1.2	11.7	-0.4	-3.4	-0.3	-0.4	0.5	-0.3	-0.2	-0.2	-0.4	-1.7	-0.1	-0.2	0.2
Systolic Blood Pressure	0.2	1.2	4.7	-1.3	-0.6	0.1	-0.8	-1.6	-0.9	-0.8	-1.0	0.7	0.9	-2.2	-1.0	-1.0
Allergy or Eczema	0.2	0.5	2.2	-1.5	-0.2	-0.2	0.3	0.8	0.3	1.4	0.3	0.4	-0.4	0.1	0.3	0.5
Cardiovascular Disease	0.2	0.7	2.7	-1.6	0.5	-0.6	0.0	-0.6	0.1	-0.0	0.1	1.3	1.3	-1.6	0.1	-0.2
Lung FEV1/FVC ratio	0.2	1.0	7.1	-0.1	-0.3	2.7	0.2	0.6	0.3	1.8	0.3	-0.3	0.0	1.1	0.3	0.2
Medication: Co-codamol	0.2	0.2	0.9	0.1	-0.9	0.1	-0.3	-0.2	-0.5	-0.4	-0.6	0.0	-0.2	-0.7	-0.6	-0.1
Maternal smoking around birth	0.2	0.2	1.6	1.1	1.3	0.1	0.1	-0.1	0.1	-0.2	0.1	0.1	0.3	-0.0	0.1	-0.1
Taking other prescription medications	0.2	0.3	1.0	-0.4	0.2	-0.8	0.4	0.2	0.3	0.0	0.3	1.0	0.7	-0.5	0.3	0.4
High blood pressure	0.2	0.6	2.8	-1.0	-0.6	0.4	-0.1	-0.8	-0.1	-0.7	-0.1	1.1	0.9	-1.7	-0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	3.9	-2.0	0.2	-0.2	0.0	0.6	0.1	1.4	0.0	0.2	-0.7	0.0	0.0	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.6	-1.3	1.2	-0.8	-0.2	-0.2	-0.1	0.1	-0.1	0.0	-0.3	-0.5	-0.1	0.0
Hair/balding pattern: Pattern 2	0.2	0.3	1.6	1.1	1.2	0.6	0.1	0.0	-0.0	0.3	-0.0	-0.1	0.5	0.1	-0.0	0.2
Forced vital capacity (FVC)	0.2	0.8	2.9	-1.1	0.7	1.0	0.5	1.0	0.6	1.7	0.7	-0.1	-0.0	1.2	0.7	0.6
Mouth/teeth dental problems	0.2	0.3	2.7	-1.6	-0.4	0.7	-0.0	-0.1	0.0	0.1	0.1	0.4	0.1	-0.5	0.1	0.0
Heart attack	0.2	0.3	1.5	-0.1	0.8	-1.2	-0.2	-0.3	-0.1	-0.0	-0.1	0.3	0.3	-1.0	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	-0.4	1.1	0.0	0.1	0.3	0.1	1.1	0.1	-0.6	-0.2	0.8	0.1	-0.0
Arm fat percentage (right)	0.2	0.7	2.3	-1.5	0.1	-1.1	-0.6	-0.7	-0.5	-1.0	-0.4	0.4	-0.4	-1.5	-0.4	-0.5
Noisy workplace	0.2	0.3	0.7	0.5	-0.5	0.7	0.5	0.4	0.5	-0.2	0.4	0.8	0.7	0.3	0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	4.0	0.4	-0.0	2.0	0.3	0.3	0.4	0.4	0.4	-0.0	0.4	1.1	0.4	0.4
Medication: Cholesterol lowering	0.2	0.3	1.6	0.1	0.5	-0.4	-0.0	-0.6	-0.1	-0.5	-0.1	0.7	1.3	-1.0	-0.1	-0.4
Impedance of arm (left)	0.2	1.0	3.0	1.5	-0.9	0.4	-0.9	-1.0	-0.9	-1.7	-0.9	-1.2	-0.5	-0.8	-0.9	-0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	0.4	0.7	1.2	0.5	0.4	0.5	0.4	0.5	0.4	0.8	0.7	0.5	0.3
Birth weight	0.2	0.5	1.9	-0.1	1.4	0.2	0.5	0.8	0.6	0.8	0.6	-0.2	-0.1	1.3	0.6	0.5
Number of full brothers	0.2	0.3	1.2	-0.4	0.1	1.1	0.4	0.6	0.5	0.6	0.6	0.6	0.3	0.1	0.6	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	-0.6	0.1	-1.1	-0.4	-0.0	-0.5	-0.1	-0.5	-0.3	-0.7	-0.6	-0.5	-0.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-0.8	0.5	0.1	0.7	0.7	0.7	0.1	0.6	1.1	0.3	-0.1	0.6	0.7
Age at first live birth	0.2	0.4	1.9	0.1	1.4	0.4	0.0	0.2	0.2	1.0	0.2	-0.8	-0.1	0.9	0.2	-0.3
Emphysema/chronic bronchitis	0.2	0.2	0.9	-0.3	0.9	-0.5	0.2	0.5	0.3	0.5	0.3	0.4	-0.2	-0.2	0.3	0.3
Suffer from ‘nerves’	0.2	0.3	1.3	1.1	1.1	-0.2	0.2	0.1	0.0	-0.2	-0.0	-0.4	0.4	0.6	-0.0	0.3
Hypertension (Self-reported)	0.2	0.5	1.9	-0.7	-0.3	0.5	0.2	-0.5	0.2	-0.5	0.2	1.4	1.3	-1.4	0.2	0.0
Illnesses of siblings: Diabetes	0.2	0.3	1.7	1.2	-0.2	0.3	-0.0	-0.5	-0.1	-1.3	-0.2	0.0	0.3	0.3	-0.2	-0.1
Smoking status: Previous	0.2	0.3	1.1	1.1	0.8	-0.8	0.5	0.4	0.3	-0.3	0.2	0.2	0.7	0.2	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.2	-0.7	0.9	0.6	0.4	0.6	0.4	1.5	0.4	-0.2	0.0	1.2	0.4	0.2
Arm fat percentage (left)	0.2	0.6	2.3	-1.5	0.0	-0.9	-0.6	-0.7	-0.5	-0.9	-0.5	0.3	-0.6	-1.4	-0.5	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.8	0.7	0.8	0.2	0.2	0.5	0.2	0.4	0.2	-0.3	-0.2	0.9	0.2	0.2
Medication for cholesterol	0.2	0.2	1.1	-0.0	0.3	0.2	0.4	0.6	0.5	0.2	0.5	0.0	-0.1	1.1	0.5	0.6
Hearing aid user	0.2	0.3	1.0	0.3	0.7	-0.4	-0.5	-0.6	-0.5	-0.2	-0.6	-0.2	-0.0	-1.0	-0.6	-0.6
Mother’s age at death	0.2	0.2	1.6	1.1	-0.1	1.3	0.1	0.2	0.0	0.0	-0.0	-0.3	0.1	0.5	-0.0	-0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.8	0.9	-0.1	1.4	0.3	0.1	0.2	0.2	0.3	-0.3	0.6	0.8	0.3	-0.2
High cholesterol (Self-reported)	0.2	0.4	1.7	0.4	1.2	-0.2	0.0	-0.8	-0.1	-0.4	-0.1	0.5	1.3	-0.9	-0.1	-0.3
Medication: Atorvastatin	0.2	0.2	0.8	0.9	0.8	-0.4	-0.0	-0.4	0.0	-0.3	0.1	0.3	0.7	-0.6	0.1	-0.2
Leg fat percentage (left)	0.2	0.9	3.4	-1.8	-0.5	-1.0	-0.7	-0.9	-0.7	-0.8	-0.7	0.3	-0.6	-1.7	-0.7	-0.7
Age started oral contraceptive pill	0.2	0.3	2.6	1.6	0.6	0.6	-0.1	-0.2	-0.2	-0.4	-0.1	-0.6	0.1	0.3	-0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.7	0.9	0.3	-0.5	0.2	0.9	0.2	0.7	0.2	-1.0	-1.1	1.7	0.2	0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	-0.0	-0.2	-0.7	0.2	0.2	0.3	0.7	0.3	-0.2	-0.2	0.9	0.3	0.1
HbA1C	0.1	0.1	0.3	-0.6	0.5	-0.2	0.1	0.4	0.0	0.3	0.0	0.2	-0.1	-0.1	0.0	-0.0
Blood Eosinophil Count	0.1	0.8	3.0	-1.7	-0.9	-1.7	-0.5	0.0	-0.3	0.2	-0.3	-0.4	-1.7	-0.3	-0.3	-0.4
Waist Hip Ratio (WHR)	0.1	0.5	3.6	1.9	1.3	-0.1	-0.0	-0.3	-0.1	-0.3	-0.1	-0.1	1.0	-0.3	-0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	-1.0	0.2	-0.6	0.0	-0.1	0.1	0.1	0.1	0.4	0.2	-0.7	0.1	-0.0
Lung FVC	0.1	0.7	2.9	0.8	-0.9	-0.2	-0.9	-0.4	-0.7	0.3	-0.6	-1.7	-1.2	0.1	-0.6	-0.8
Relative age of first facial hair	0.1	0.1	0.5	-0.7	-0.7	0.1	0.1	0.3	0.3	0.3	0.3	0.2	-0.0	0.1	0.3	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.9	1.0	-0.4	-0.2	-0.2	0.2	-0.1	0.3	-0.1	-0.8	-0.3	0.5	-0.1	-0.2
Systolic blood pressure, automated reading	0.1	0.3	1.2	0.5	0.0	1.0	-0.1	-0.5	-0.1	0.0	-0.0	0.6	1.1	-0.6	-0.0	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.2	-0.5	0.5	-0.1	-0.5	-0.2	-0.1	-0.1	0.0	0.4	-0.1	-0.1	-0.1
Impedance of leg (right)	0.1	0.6	1.4	0.4	-1.2	-0.0	-0.7	-0.9	-0.7	-0.8	-0.8	-0.7	-0.2	-0.8	-0.8	-0.8
Trunk fat percentage	0.1	0.5	2.2	-1.5	-0.2	-0.5	-0.6	-0.5	-0.4	-0.6	-0.4	0.2	-0.6	-1.1	-0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	0.4	0.3	-0.6	0.1	0.3	0.2	-0.7	0.1	0.3	-0.2	-0.0	0.1	0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.8	-0.1	-0.6	-0.9	-0.3	-0.5	-0.4	-0.1	-0.5	-0.1	-0.1	-0.4	-0.5	-0.4
Body mass index (BMI)	0.1	0.5	4.5	-2.1	0.2	-0.7	-0.0	-0.0	0.0	0.1	0.0	0.9	-0.2	-0.8	0.0	0.1
Impedance of leg (left)	0.1	0.6	1.7	0.1	-1.3	0.1	-0.7	-0.9	-0.8	-0.9	-0.8	-0.7	-0.2	-0.8	-0.8	-0.8
Trunk fat mass	0.1	0.3	3.1	-1.8	0.6	-0.1	0.0	0.2	0.2	0.3	0.2	0.6	-0.2	-0.3	0.2	0.1
Waist circumference	0.1	0.2	1.0	-1.0	0.7	-0.2	-0.3	-0.4	-0.3	0.0	-0.3	0.2	0.0	-0.8	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	3.0	-0.8	-1.7	0.5	-0.0	0.1	0.1	0.1	0.1	0.5	0.1	-0.1	0.1	0.2
Diabetes (self-reported)	0.1	0.2	1.3	0.5	1.1	0.2	0.3	0.1	0.3	0.6	0.4	0.2	0.7	0.2	0.4	0.1
Impedance of arm (right)	0.1	0.4	1.7	1.3	-0.3	0.5	-0.3	-0.5	-0.3	-1.3	-0.3	-0.5	0.2	-0.3	-0.3	-0.3
Hip circumference	0.1	0.6	2.9	-1.7	1.1	1.0	0.4	0.5	0.5	0.8	0.5	0.8	0.2	0.2	0.5	0.5
Arm fat mass (right)	0.1	0.4	3.5	-1.9	0.8	-0.7	-0.0	0.0	0.1	0.0	0.1	0.6	-0.3	-0.6	0.1	0.1
Exposure to tobacco smoke at home	0.1	0.2	1.3	0.4	1.1	-0.0	0.2	0.3	0.2	-0.4	0.2	0.0	-0.2	0.2	0.2	0.5
Peak expiratory flow (PEF)	0.1	0.3	1.4	-1.2	-0.4	1.0	0.2	0.5	0.2	1.1	0.2	0.2	-0.2	0.4	0.2	0.1
Body fat percentage	0.1	0.5	2.1	-1.4	-0.1	-0.7	-0.6	-0.7	-0.5	-0.8	-0.5	0.3	-0.4	-1.4	-0.5	-0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.5	0.5	0.3	0.7	0.2	0.1	0.3	-0.0	0.3	0.2	0.7	-0.1	0.3	0.2
Whole body fat mass	0.1	0.4	3.2	-1.8	0.7	-0.2	0.1	0.2	0.3	0.4	0.3	0.8	-0.1	-0.4	0.3	0.2
Leg fat mass (right)	0.1	0.3	2.5	-1.6	0.7	-0.4	0.1	0.0	0.1	0.0	0.1	0.7	-0.1	-0.5	0.1	0.1
Overall health rating	0.1	0.2	0.6	-0.1	0.2	-0.8	0.3	-0.1	0.2	-0.4	0.3	0.5	0.6	-0.6	0.3	0.2
Leg pain on walking	0.1	0.1	0.8	-0.5	-0.1	0.1	-0.1	0.3	-0.1	0.9	-0.1	0.2	-0.5	-0.4	-0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	0.6	0.3	0.2	-0.1	-0.3	-0.2	-0.8	-0.2	-0.5	-0.1	0.1	-0.2	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.7	-0.2	0.4	-0.0	0.2	0.0	0.2	-0.2	0.2	0.9	0.5	-0.8	0.2	0.3
Diabetes diagnosed by doctor	0.1	0.1	0.8	0.9	0.6	-0.1	-0.1	-0.3	-0.0	-0.3	0.0	-0.1	0.5	-0.2	0.0	-0.2
Mineral and other dietary supplements	0.1	0.1	0.3	0.2	-0.1	-0.1	0.2	0.2	0.2	-0.3	0.2	0.6	0.1	-0.2	0.2	0.6
Arm fat mass (left)	0.1	0.4	3.8	-1.9	0.6	-0.6	-0.2	-0.0	-0.1	0.1	-0.1	0.4	-0.4	-0.7	-0.1	-0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.9	-0.7	0.2	-0.5	-0.3	-0.7	-0.3	-0.5	-0.3	0.2	0.5	-0.9	-0.3	-0.4
Financial situation satisfaction	0.1	0.2	1.4	-0.4	-1.2	0.1	-0.1	0.2	-0.1	-0.3	-0.1	0.3	-0.3	-0.3	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	1.4	1.2	0.3	-0.4	0.0	0.2	-0.0	-0.0	0.0	-0.3	-0.1	0.3	0.0	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.8	-0.2	-0.9	-0.5	-0.1	-0.3	-0.1	-0.2	-0.1	0.5	0.6	-0.7	-0.1	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.6	-0.8	-0.1	-0.5	0.0	-0.1	0.0	0.3	0.0	0.6	0.4	-0.5	0.0	-0.1
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.4	-0.8	-0.3	-0.2	-0.6	-0.2	-0.5	-0.3	0.7	0.6	-0.9	-0.3	-0.2
Impedance of whole body	0.1	0.5	1.2	0.9	-0.9	0.4	-0.6	-0.7	-0.6	-1.1	-0.6	-0.8	-0.2	-0.5	-0.6	-0.6
Leg fat mass (left)	0.1	0.4	3.5	-1.9	0.5	-0.5	0.0	0.0	0.1	0.1	0.0	0.8	-0.2	-0.6	0.0	0.1
Hair Pigment	0.0	0.2	0.6	-0.0	0.0	0.6	-0.0	0.3	-0.2	0.6	-0.2	-0.6	-0.8	0.7	-0.2	0.1
Relative age voice broke	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.1	0.2	0.1	0.2	0.1	0.2	0.1	0.1	0.1	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.1	0.3	0.1	-0.1	0.6	0.2	0.1	0.2	-0.2	0.1	0.3	0.2	-0.1	0.1	0.2
Had major operations	0.0	0.0	0.4	-0.1	-0.1	-0.7	0.0	-0.0	-0.0	0.1	-0.1	0.2	0.1	-0.1	-0.1	0.2
Miserableness	0.0	0.1	0.4	0.6	0.0	0.1	0.0	0.0	0.1	-0.2	0.2	0.2	0.4	-0.1	0.2	0.1
Medication: Lisinopril	0.0	0.0	0.2	0.2	0.3	-0.4	0.1	0.0	0.0	0.1	0.0	0.3	0.2	-0.4	0.0	0.1

Hub : Genes

LPXN

Models

Trait associations