TWAS hub - LRCH4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1210	0.0540	4.1e-03	0.040	NA	0.070	NA	0.049	3.0e-03	NA	1.1e-04	NA	1.1e-03
2	GTEx	Esophagus Muscularis	0.1990	0.0610	9.0e-04	0.144	NA	0.129	NA	0.134	4.8e-09	NA	3.1e-08	NA	1.7e-08
3	GTEx	Nerve Tibial	0.3438	0.0613	7.8e-10	0.223	NA	0.228	NA	0.233	8.9e-16	NA	3.5e-16	NA	1.7e-16
4	GTEx	Thyroid	0.1750	0.0610	2.8e-03	0.142	NA	0.118	NA	0.126	5.8e-11	NA	2.8e-09	NA	7.6e-10
5	YFS	Blood	0.0443	0.0261	3.1e-04	0.005	0.009	0.023	0.013	0.017	8.0e-03	0.00031	2.9e-08	3.3e-05	2.3e-06
6	TCGA	Breast Invasive Carcinoma	0.0139	0.0086	9.8e-03	0.003	0.012	0.005	NA	0.002	6.1e-02	0.00150	2.8e-02	NA	1.2e-01
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0338	0.0180	1.3e-03	0.006	0.013	0.006	NA	0.008	6.8e-02	0.01200	5.5e-02	NA	3.8e-02
8	TCGA	Brain Lower Grade Glioma	0.0637	0.0341	6.9e-04	-0.002	0.019	0.015	NA	0.001	6.1e-01	0.00260	7.1e-03	NA	2.1e-01
9	TCGA	Liver Hepatocellular Carcinoma	0.1570	0.0790	3.0e-04	0.006	0.070	0.084	NA	0.044	1.6e-01	0.00034	9.0e-05	NA	3.8e-03
10	TCGA	Prostate Adenocarcinoma	0.0270	0.0153	5.8e-03	0.026	0.016	0.010	NA	0.019	8.3e-04	0.00740	2.8e-02	NA	3.6e-03
11	TCGA	Thyroid Carcinoma	0.0720	0.0360	2.7e-03	0.008	0.008	0.017	NA	0.017	4.7e-02	0.05500	8.3e-03	NA	7.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Blood Red Count	14.6	140.7	524.4	-11.7	-7.9	-9.1	-8.4	12.4	22.9	4.8	6.9	15.7	12.4	6.7
Medication: Seretide 50 evohaler	5.9	6.8	11.1	-2.8	-2.8	-2.4	-2.8	-1.3	3.2	-2.9	-3.3	-0.6	2.9	2.3
Father’s age at death	5.0	6.7	11.1	2.9	3.0	3.1	2.9	0.7	-1.6	3.3	2.9	3.0	-2.8	0.2
Wheeze or whistling in the chest in last year	4.6	8.1	13.1	-3.4	-3.4	-3.1	-3.3	0.6	3.6	-3.1	-2.8	-1.3	3.6	0.4
Prostate Cancer	4.4	6.1	10.0	-3.2	-2.6	-2.9	-2.7	-1.7	3.0	-1.4	-2.7	-0.5	2.8	2.3
Cholesterol lowering medication	4.2	6.3	11.4	3.0	3.1	2.7	3.1	0.1	-3.4	2.2	1.9	-1.2	-3.2	-1.0
Lung FEV1/FVC ratio	3.5	17.7	32.8	5.4	4.6	3.8	4.5	-2.3	-5.7	5.3	3.4	1.9	-4.6	-2.4
Pulse rate, automated reading	3.5	11.3	68.7	0.8	-0.7	0.1	-0.5	-8.3	1.2	-3.2	-4.5	-4.7	0.8	0.4
Had menopause	3.4	4.3	7.1	2.7	2.5	2.3	2.5	0.4	-2.5	2.2	2.1	0.7	-2.4	-0.6
Asthma	3.0	5.9	10.4	-3.2	-2.9	-2.3	-2.9	0.3	2.8	-2.9	-2.4	-1.0	2.9	1.0
Age at first live birth	3.0	5.2	10.9	1.9	2.1	2.3	2.4	3.3	-1.5	1.9	3.3	2.2	-2.6	-0.4
Mineral and other dietary supplements	3.0	4.0	7.0	-2.1	-2.5	-2.6	-2.6	-0.7	2.2	-1.5	-1.7	-0.8	2.6	-1.5
Blood Platelet Count	2.9	33.5	148.8	-0.0	-1.2	-1.2	-1.3	-12.2	-4.9	-2.5	-10.7	-6.1	0.2	5.8
Nervous feelings	2.9	5.4	10.3	-2.9	-2.6	-2.7	-2.7	-0.2	3.2	-2.0	-2.1	-0.2	2.8	1.7
Respiratory disease	2.7	6.1	12.3	-3.5	-2.8	-2.2	-2.7	1.0	2.6	-3.5	-2.3	-1.6	2.6	0.8
Supplements: Glucosamine	2.7	3.5	6.7	1.7	1.8	2.3	2.0	2.6	-1.4	1.2	2.4	1.8	-2.0	0.1
Chronic bronchitis/emphysema (father)	2.7	3.1	4.9	-1.8	-2.1	-2.1	-2.0	-0.6	1.5	-2.1	-1.5	-1.7	2.2	-0.9
High blood pressure (siblings)	2.6	3.7	6.8	2.6	2.2	2.2	2.4	0.6	-2.0	1.5	2.3	0.6	-2.4	-0.7
Pulse rate	2.5	4.2	21.4	0.0	-0.9	-0.4	-0.9	-4.6	1.4	-1.7	-3.1	-2.4	1.0	1.5
Diabetes diagnosed by doctor	2.5	4.1	7.6	-2.7	-2.3	-2.7	-2.4	1.2	0.6	-1.7	-2.4	-1.8	2.3	0.1
Supplements: Fish oil (including cod liver oil)	2.5	3.3	6.8	2.1	2.3	2.2	2.4	-1.0	-2.6	0.5	0.3	-0.4	-2.4	1.3
Average weekly beer plus cider intake	2.5	3.6	7.3	-2.1	-2.0	-2.2	-2.0	-1.3	1.1	-1.6	-2.3	-2.7	2.0	0.5
Breastfed as a baby	2.4	3.0	5.2	1.2	1.6	1.9	1.7	2.0	-1.0	2.2	2.3	1.9	-1.8	0.2
Diabetes (self-reported)	2.3	3.5	6.2	-2.5	-2.2	-2.4	-2.1	1.7	0.3	-1.3	-2.2	-1.8	2.0	-0.1
Asthma (self-reported)	2.3	4.5	7.6	-2.8	-2.5	-1.9	-2.4	0.4	2.5	-2.7	-2.3	-0.9	2.4	1.2
Loud music exposure frequency	2.2	2.4	3.4	-1.8	-1.9	-1.6	-1.8	1.4	1.7	-1.3	-1.7	-0.7	1.8	0.8
High cholesterol (Self-reported)	2.1	3.7	6.1	2.1	2.4	2.1	2.4	0.9	-2.0	2.3	1.8	0.2	-2.5	0.9
Risk taking	2.1	3.0	6.6	-1.7	-2.0	-1.9	-1.9	1.4	2.6	-2.1	-0.6	-0.8	2.2	-0.7
Alzheimer’s Disease (including proxy)	2.0	2.8	15.6	-0.2	0.3	0.1	0.2	0.1	-2.7	1.9	2.0	-0.8	-0.4	-3.9
Age at First Birth	2.0	2.9	8.5	2.8	2.8	2.6	2.9	0.7	0.0	0.0	0.0	0.0	0.0	0.0
Medication: Blood pressure	2.0	3.5	12.6	-1.1	-1.2	-0.8	-1.3	1.0	1.9	-2.2	-3.1	-0.8	1.1	3.5
Had other major operations	1.9	2.3	9.8	0.4	0.6	0.5	0.5	1.7	0.3	1.8	-0.1	2.9	-0.6	3.1
Type 2 Diabetes (T2D) (2018)	1.8	3.4	7.0	-2.5	-2.2	-2.3	-2.1	2.7	1.2	-1.5	-1.2	-0.7	2.1	-0.3
Medication: Metformin	1.8	2.5	7.9	-1.7	-1.4	-1.5	-1.4	-0.1	-0.2	-1.9	-2.8	-2.1	1.5	-0.3
Qualifications: CSEs or equivalent	1.8	2.3	4.1	-1.7	-1.5	-1.3	-1.6	-1.6	1.1	-1.9	-2.0	-1.7	1.4	0.4
Heart attack	1.8	2.3	4.0	-1.7	-1.8	-1.7	-1.8	0.6	1.6	-2.0	-1.8	-0.8	1.8	0.1
Chest pain or discomfort	1.8	2.6	6.2	-2.2	-1.5	-1.5	-1.8	-0.1	2.5	-0.6	-1.4	0.5	1.9	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	7.9	-1.4	-2.2	-1.8	-2.0	-2.0	0.4	-2.6	-2.8	-2.7	1.7	-0.3
Average weekly red wine intake	1.8	2.6	4.3	1.8	1.8	1.0	1.9	1.8	-1.9	1.9	2.1	0.6	-1.8	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	7.1	1.2	1.1	1.4	1.0	2.7	-0.6	1.0	1.7	1.7	-0.9	-0.3
Wears glasses or contact lenses	1.8	2.1	5.7	1.2	1.4	1.4	1.4	1.5	-1.2	1.7	2.4	0.4	-1.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	7.2	0.7	1.1	1.4	1.2	2.7	0.3	1.3	2.0	1.5	-0.9	1.0
Age at last live birth	1.7	2.5	4.9	1.5	1.9	2.0	1.8	1.6	-1.5	1.3	1.6	0.6	-2.2	0.4
Hearing aid user	1.7	1.9	3.3	1.4	1.8	1.6	1.7	-0.7	-1.1	1.7	0.9	1.2	-1.5	1.1
Number of operations (self-reported)	1.7	2.5	9.1	0.6	0.7	0.4	0.7	3.0	0.9	1.3	0.7	2.9	-0.4	2.4
Age started oral contraceptive pill	1.7	2.2	3.6	1.5	1.7	1.8	1.9	1.4	-1.3	1.2	1.8	0.5	-1.8	-0.7
Bipolar Disorder or Schizophrenia	1.6	4.0	8.0	2.8	2.8	2.8	2.5	0.3	-0.8	1.3	2.0	1.5	-2.3	0.0
Schizophrenia (2018)	1.6	3.4	6.3	2.4	2.5	2.4	2.3	-0.2	-0.8	1.5	2.3	1.5	-2.0	0.0
Serious illness, injury or assault to yourself	1.6	1.9	7.1	-0.8	-0.8	-0.8	-0.9	0.8	2.7	-1.1	-0.6	1.6	1.1	2.4
Medication: Atenolol	1.6	1.9	4.1	1.8	1.8	1.7	1.7	-0.8	-2.0	0.7	0.4	-0.5	-1.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	4.7	-1.3	-1.8	-1.7	-1.9	-0.1	2.0	-1.5	-0.2	-0.2	2.1	-2.2
Comparative body size at age 10	1.6	4.5	8.2	2.3	2.2	1.7	2.2	1.5	-2.5	1.3	2.8	0.1	-2.2	-2.9
Qualifications: nursing, teaching	1.6	2.5	6.6	-1.4	-1.9	-1.7	-1.6	0.5	1.1	-2.6	-0.3	-1.5	1.6	-2.0
Illnesses of father: High blood pressure	1.6	2.0	3.1	1.8	1.6	1.4	1.6	-0.7	-1.0	1.5	1.7	1.2	-1.6	-1.1
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.4	-1.3	-1.8	-1.6	-1.8	0.2	1.8	-1.8	-0.8	-0.7	1.8	-1.1
Lung cancer (father)	1.5	1.7	2.8	1.4	1.1	1.2	1.2	-1.3	-1.7	0.3	-1.6	-0.9	-1.4	1.6
Handedness (chirality/laterality): Left-handed	1.5	1.8	9.6	-0.6	-0.9	-1.4	-0.9	-0.4	-0.4	-1.4	-1.3	-3.1	0.7	-1.3
Medication for cholesterol	1.5	2.3	4.6	-1.7	-1.9	-1.5	-1.9	-0.4	1.8	-2.1	-1.2	0.1	1.8	-0.5
Eye problems/disorders: Glaucoma	1.5	1.8	5.0	-1.4	-1.0	-1.0	-0.8	0.0	2.0	0.6	-0.8	2.2	1.2	1.9
Migraine (self-reported)	1.4	1.7	4.5	1.0	1.2	1.1	1.1	-0.1	-1.4	1.5	2.1	0.6	-1.1	-1.8
Schizophrenia (2014)	1.3	2.8	6.6	2.0	2.3	2.1	2.0	-0.8	0.5	1.1	1.5	2.6	-1.6	0.0
High blood pressure (mother)	1.3	1.9	4.2	-1.3	-1.4	-0.9	-1.5	-0.5	1.7	-2.0	-1.9	-1.0	1.4	0.6
Hair/balding pattern: Pattern 2	1.3	1.6	3.5	-0.9	-1.1	-1.1	-1.2	-0.5	1.9	-1.4	-1.8	-0.6	1.0	1.7
Medication: Ramipril	1.3	1.6	3.6	-1.2	-1.1	-0.7	-1.1	-1.9	0.4	-1.9	-1.8	-1.1	1.2	-0.4
Happiness	1.3	1.5	5.1	0.9	1.3	1.2	1.2	0.3	0.3	1.5	1.3	2.3	-1.0	1.0
Average weekly champagne plus white wine intake	1.3	1.7	5.7	0.8	0.6	1.0	0.6	1.6	0.1	0.7	2.4	2.1	-0.7	-1.7
Alzheimer’s Disease (in mother)	1.2	1.4	9.7	-0.6	-0.4	-0.3	-0.3	0.7	-1.2	0.8	1.3	-0.5	0.3	-3.1
Ulcerative Colitis	1.2	1.7	3.6	1.6	1.6	1.7	1.4	-1.5	-0.3	0.0	0.9	1.9	-1.4	0.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	9.3	0.4	1.2	1.4	1.1	2.0	0.6	1.6	2.3	3.1	-1.0	1.0
Noisy workplace	1.2	1.4	3.1	1.3	1.2	1.3	1.1	-0.6	-0.9	1.7	0.7	1.0	-1.2	1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.6	-1.1	-0.9	-0.4	-0.9	0.5	1.7	-1.9	-1.8	-0.1	0.7	1.8
Number of full sisters	1.2	1.4	2.1	-1.0	-1.4	-1.4	-1.4	1.1	1.1	-1.4	-1.1	-0.5	1.4	-0.8
Alcohol drinker status: Never	1.2	1.5	2.7	0.9	1.5	1.4	1.3	0.1	-1.0	1.1	1.6	1.1	-1.6	0.7
Crohns Disease (2017)	1.1	2.4	4.5	-1.5	-1.3	-1.5	-1.5	-1.7	2.0	-1.4	-2.1	-0.7	1.8	0.7
Crohns Disease (2012)	1.1	1.7	4.6	-1.7	-1.2	-1.7	-1.4	-0.7	2.1	-1.2	-0.5	0.3	1.6	0.0
Blood White Count	1.1	7.9	14.3	-3.3	-3.1	-3.3	-3.5	-1.6	3.5	-0.8	-3.2	0.1	3.8	1.9
Heel T-Score	1.1	8.7	31.0	0.5	1.2	-0.0	1.1	5.6	-1.3	2.1	5.5	1.2	-0.7	-4.8
Hypothyroidism (self reported)	1.1	2.6	6.4	-2.3	-1.9	-1.9	-1.8	2.5	0.4	-1.4	-0.5	-1.0	1.6	-0.7
Medication: Co-codamol	1.1	1.3	1.9	1.1	1.0	1.2	1.1	1.2	-0.4	1.4	1.3	1.3	-1.0	1.1
Stomach or abdominal pain in last month	1.1	1.4	6.2	-1.1	-0.7	-0.8	-0.8	2.5	1.0	0.7	0.6	1.4	0.7	1.3
Tense / ‘highly strung’	1.1	1.8	4.3	-1.1	-1.4	-1.5	-1.4	-1.6	2.1	-1.4	-1.2	-0.1	1.6	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.6	0.5	0.6	0.2	0.7	-0.2	-1.0	1.9	2.6	0.7	-0.6	-2.6
Glaucoma (self-reported)	1.1	1.3	5.8	-0.8	-0.6	-0.8	-0.5	-0.1	1.7	0.8	-0.4	2.4	0.8	1.4
Medication: Blood pressure	1.1	2.1	4.4	1.3	1.8	1.3	1.9	0.7	-1.5	1.7	2.1	-0.2	-1.6	-0.6
Medication: Atorvastatin	1.1	1.4	2.9	1.6	1.4	1.7	1.5	-0.3	-1.5	0.5	-0.1	-0.6	-1.6	0.1
Relative age voice broke	1.0	1.5	4.1	2.0	1.6	1.9	1.3	-0.6	-0.2	0.7	0.9	1.3	-1.3	0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.8	0.3	0.7	1.1	0.8	1.7	0.1	1.3	1.0	1.4	-0.6	1.3
Forced vital capacity (FVC)	1.0	3.9	9.9	-1.2	-1.9	-1.5	-2.0	-2.0	1.8	-3.1	-2.4	-2.0	1.8	1.1
Illnesses of siblings	1.0	1.5	2.8	-1.6	-1.5	-1.7	-1.6	-0.1	1.0	-0.8	-1.3	-0.3	1.6	0.0
Forced vital capacity (FVC), Best measure	1.0	3.8	8.0	-1.2	-2.0	-1.7	-2.0	-1.8	1.4	-2.8	-2.6	-2.1	1.7	1.4
Suffer from ‘nerves’	1.0	1.5	3.4	-0.9	-1.0	-1.1	-1.1	-1.2	1.8	-0.8	-1.5	0.2	1.3	1.8
Breast cancer (self-reported)	1.0	1.1	6.3	0.2	0.1	0.5	0.0	-2.5	0.3	-0.4	-1.4	0.6	-0.1	1.8
Financial situation satisfaction	1.0	1.2	2.5	1.0	1.1	1.2	1.3	-0.6	-1.6	0.9	-0.6	-0.7	-1.3	1.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.0	0.5	1.3	1.2	1.3	0.9	-0.7	1.4	1.3	1.3	-1.3	0.6
Heart attack/myocardial infarction (self-reported)	1.0	1.4	3.1	-1.1	-1.3	-1.2	-1.3	0.7	1.2	-1.8	-1.2	-0.7	1.3	-0.2
Reaction Time	0.9	1.7	7.7	-1.0	-1.1	-0.8	-1.1	1.4	2.8	-1.2	0.1	1.0	1.4	0.1
Diabetes (father)	0.9	1.1	2.4	-1.6	-1.3	-1.6	-1.3	-0.1	0.9	-1.3	-0.1	-0.2	1.2	-0.3
Maternal smoking around birth	0.9	1.3	3.9	-1.0	-1.4	-1.4	-1.5	-0.3	0.8	-0.3	-2.0	-0.2	1.4	0.7
Fed-up feelings	0.9	1.6	3.1	-1.1	-1.3	-1.2	-1.5	-0.9	0.8	-1.6	-1.8	-1.0	1.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.0	1.1	1.0	0.6	1.0	0.2	-0.3	1.6	0.2	1.7	-0.6	1.5
Neuroticism score	0.9	1.9	4.2	-1.6	-1.4	-1.3	-1.4	-0.5	2.0	-1.6	-1.5	-0.3	1.6	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.5	-1.5	-1.5	-1.3	-1.6	-0.5	1.2	-1.5	-0.6	-0.5	1.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.7	-0.1	1.0	0.6	0.8	0.5	-1.1	1.9	1.3	1.2	-0.9	-0.5
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.0	0.7	0.3	0.9	0.4	1.6	1.1	0.0	-0.8	1.1	-0.3	2.0
Eye problems/disorders: None of the above	0.9	1.0	2.1	-1.0	-1.0	-1.5	-1.2	-1.2	0.7	-0.6	-0.7	-0.7	1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	4.5	0.4	0.8	0.4	0.9	-1.1	-2.1	1.0	0.7	-0.7	-0.9	-0.9
Worry (Nagel 2018)	0.8	1.7	5.4	-1.0	-0.8	-1.2	-0.8	-1.0	2.3	-0.7	-1.0	0.6	1.3	2.1
Alzheimer’s Disease (in father)	0.8	0.9	3.3	0.0	0.1	-0.3	-0.0	0.0	-1.6	1.4	1.1	-0.9	-0.1	-1.8
Lupus	0.8	1.1	2.6	-0.9	-0.8	-1.6	-1.2	-1.1	1.0	-0.6	-0.4	0.4	1.2	1.5
Primary Biliary Cirrhosis	0.8	1.2	3.6	-1.0	-1.1	-1.0	-1.0	-1.0	0.6	-1.9	-0.9	-1.6	0.8	-0.4
Allergy or Eczema	0.8	2.0	5.9	0.0	1.1	1.3	0.9	2.1	0.6	1.0	2.0	2.4	-0.9	1.3
Allergy	0.8	1.8	7.1	1.2	0.4	-0.1	0.4	-2.7	-1.4	-0.2	-1.4	-2.5	-0.5	-0.5
Medication: Simvastatin	0.8	1.1	2.4	1.0	1.3	1.0	1.2	0.6	-1.5	0.3	0.1	-1.3	-1.4	0.9
Fluid intelligence score	0.8	1.7	3.4	1.3	1.6	1.3	1.8	-0.2	-1.2	1.0	1.8	-0.2	-1.6	-0.4
Had major operations	0.8	1.0	3.2	-0.9	-0.6	-0.5	-0.7	1.5	1.4	-0.3	-0.4	0.8	0.6	1.8
Mood swings	0.8	1.5	2.4	-1.3	-1.4	-1.4	-1.6	0.7	0.9	-1.5	-1.4	-0.4	1.4	-0.9
Eye problems/disorders: Cataract	0.8	0.9	2.3	-0.7	-0.8	-0.1	-1.0	-1.1	1.1	-1.5	-1.3	-0.3	0.8	0.8
Irritability	0.8	1.4	3.1	-0.9	-1.1	-1.1	-1.3	0.5	1.7	-1.8	-1.5	-0.1	1.3	0.8
Mean Putamen Volume	0.7	0.8	3.6	-0.4	-0.5	-0.1	-0.4	1.9	1.6	-0.7	-0.1	0.8	0.5	0.3
Fasting Glucose	0.7	0.9	2.7	-1.2	-1.6	-1.4	-1.6	-1.0	0.0	0.0	0.0	0.0	0.0	0.0
Vitamin and mineral supplements	0.7	0.9	2.3	0.8	0.8	0.7	0.7	-1.4	-0.5	1.5	1.0	1.0	-0.7	-0.7
Supplements: Zinc	0.7	0.8	4.2	-0.0	0.0	0.2	0.0	2.1	1.1	-0.3	0.7	1.5	0.3	-0.7
Hand grip strength (right)	0.7	1.9	5.9	-0.1	-1.4	-0.8	-1.2	-0.5	1.4	-2.4	-0.4	-1.9	1.1	-2.0
Age when periods started (menarche)	0.7	1.6	5.2	2.3	1.1	1.8	1.3	-1.6	-1.0	-0.5	-0.3	-0.1	-1.5	0.5
Multivitamins +/- minerals	0.7	0.9	2.1	-0.5	-0.6	-0.4	-0.4	1.3	0.7	-1.4	-1.3	-0.6	0.5	1.4
Number of incorrect matches in round	0.7	1.2	2.4	1.6	1.4	1.4	1.4	-0.0	-1.1	1.0	0.8	0.1	-1.3	-0.7
Alcohol usually taken with meals	0.7	1.1	2.5	-1.6	-1.1	-1.1	-1.1	0.7	1.6	-0.3	-0.2	1.1	1.3	0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.6	0.9	0.8	0.7	1.2	2.4	-1.4	0.2	1.9	-0.7	-1.2	-0.6
Medication: Lansoprazole	0.7	0.8	2.4	0.5	0.9	0.4	0.8	-1.5	-1.3	1.3	0.4	-0.3	-0.8	0.5
Hair/balding pattern: Pattern 4	0.7	1.7	5.0	0.7	0.8	1.0	0.8	2.2	-1.0	0.8	2.1	0.2	-0.9	-2.1
Shortness of breath walking on level ground	0.7	0.9	1.6	-1.0	-0.9	-0.8	-0.9	-0.8	0.7	-1.2	-1.3	-0.8	1.0	0.9
Emphysema/chronic bronchitis	0.7	0.7	3.0	0.0	-0.5	0.3	-0.1	1.4	0.9	-0.6	-0.9	0.9	0.1	1.7
Medication: Omeprazole	0.7	0.9	1.9	-0.9	-1.2	-1.4	-1.2	0.9	0.4	0.1	-0.2	0.1	1.3	-1.1
Overall health rating	0.7	1.6	2.9	-1.5	-1.2	-1.5	-1.4	-1.3	0.7	-0.7	-1.7	-1.0	1.4	0.9
Osteoarthritis (self-reported)	0.7	1.0	2.9	0.7	1.0	0.9	1.0	0.7	-1.1	0.6	1.7	0.8	-0.9	-1.0
Medication: Gliclazide	0.7	0.8	1.6	-1.2	-0.9	-1.2	-0.9	0.5	0.2	-0.8	-1.3	-0.9	1.1	0.2
Miserableness	0.7	1.2	1.9	-1.3	-1.2	-1.4	-1.3	0.7	0.6	-1.0	-0.8	-1.3	1.3	-0.9
Commuting to job workplace: Public transport	0.7	0.9	3.1	0.3	0.6	0.7	0.9	1.2	0.2	0.6	0.8	1.3	-0.7	1.8
Bipolar Disorder (2018)	0.6	0.9	2.1	1.4	1.4	1.4	1.2	0.8	-0.2	0.2	0.4	0.6	-1.2	0.0
Ulcerative Colitis (UC)	0.6	1.1	5.1	1.1	0.8	0.8	0.7	-2.3	-0.4	-0.8	-1.4	-0.2	-0.7	0.9
Breast Cancer	0.6	1.4	10.5	0.2	-0.1	-0.3	0.1	3.2	0.9	0.2	2.0	0.5	0.1	-0.3
HbA1C	0.6	0.6	3.8	0.4	0.7	1.1	0.6	-0.1	0.2	0.0	0.9	1.9	0.0	0.0
Lung FVC	0.6	2.9	7.2	-0.3	-1.0	-1.0	-1.2	-2.3	0.9	-2.7	-2.4	-2.5	1.0	1.4
Neuroticism	0.6	1.4	4.0	-1.2	-1.0	-1.1	-1.1	-0.1	2.0	-1.0	-1.4	0.4	1.3	1.3
Hand grip strength (left)	0.6	1.5	6.9	0.7	-0.6	-0.1	-0.4	0.1	0.1	-2.1	0.0	-2.0	0.2	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.3	-0.6	-1.1	-1.0	-1.1	0.5	1.2	-1.0	-1.0	-0.7	1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	5.5	-1.1	-1.1	-1.2	-1.0	2.3	0.4	-0.1	0.4	-0.7	1.0	-1.7
Hearing difficulty/problems with background noise	0.6	0.9	2.7	-0.8	-0.7	-0.6	-0.6	1.6	1.3	-1.3	-0.9	-0.5	0.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.9	-1.2	-1.3	-1.4	-1.3	1.5	0.7	-0.7	-0.3	-0.8	1.2	-1.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.4	0.8	0.8	0.9	0.9	1.2	-0.8	0.7	0.8	1.1	-1.1	0.7
Pulse wave reflection index	0.6	0.8	3.2	-0.3	-0.1	-0.3	-0.1	1.8	0.3	1.2	1.4	1.0	0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.8	-1.5	-1.0	-1.3	-1.0	2.0	-0.1	-0.7	0.5	-0.3	0.9	-0.6
Angina (self-reported)	0.6	0.7	4.7	-0.8	-0.3	-0.4	-0.6	-0.2	0.4	0.0	-1.3	0.3	0.5	2.2
Heart disease (mother)	0.6	0.7	1.4	-1.0	-0.8	-0.6	-0.9	-0.9	0.8	-1.2	-0.0	-0.8	1.0	-1.0
Leg pain on walking	0.6	0.7	3.7	-1.2	-0.6	-0.3	-0.5	1.9	0.4	0.3	0.7	0.5	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.3	-0.1	-0.7	-0.3	-0.7	-0.9	0.4	-1.8	-1.0	-1.3	0.5	-0.2
Knee pain experienced in last month	0.6	0.9	2.4	-1.2	-1.2	-1.1	-1.4	0.0	-0.0	-0.2	-1.5	-0.4	1.1	-0.1
Commuting to job workplace: Walk	0.6	0.6	2.2	-0.4	-0.7	-0.6	-0.8	-0.3	1.2	-1.5	-0.8	-0.1	0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	6.9	1.1	0.8	1.0	0.6	-2.6	-1.2	-0.4	0.1	-0.4	-0.8	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.7	-0.9	-1.2	-1.0	0.8	-0.4	0.4	0.2	-0.7	1.0	-1.4
Basal cell carcinoma (self-reported)	0.6	0.8	1.5	0.9	0.8	1.2	1.0	-0.1	-1.1	1.1	0.7	0.2	-1.1	-0.6
Irritable Bowel Disease (IBD)	0.5	1.1	5.9	0.3	0.1	0.1	-0.1	-2.4	0.9	-1.1	-1.8	-0.1	0.2	1.0
Rheumatoid Arthritis	0.5	0.7	3.3	-0.5	-0.8	-0.8	-0.8	-0.1	-0.6	-1.0	-0.8	-1.8	0.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.8	1.1	0.8	0.6	0.8	0.5	-0.8	1.3	0.3	0.6	-0.7	1.0
Angina	0.5	0.7	4.0	-0.8	-0.3	-0.4	-0.6	-0.1	0.5	-0.1	-1.2	0.4	0.5	2.0
Average weekly fortified wine intake	0.5	0.6	2.4	0.2	0.2	0.0	0.2	1.3	-0.6	0.3	1.6	-0.1	-0.2	-1.5
Medication: Levothyroxine sodium	0.5	0.8	4.9	-0.5	0.1	-0.4	-0.1	2.2	-1.2	0.5	1.2	-0.5	-0.2	-0.5
Pain all over the body in last month	0.5	0.5	2.7	-0.0	-0.5	-0.3	-0.6	-0.6	0.4	-1.1	-0.4	-0.0	0.7	-1.6
Falls in the last year	0.5	0.7	3.0	0.5	0.2	-0.2	0.1	-0.3	-1.7	0.1	-0.2	-1.7	-0.3	-1.0
Hair/balding pattern: Pattern 3	0.5	0.8	2.1	0.0	0.5	0.5	0.6	0.7	-0.6	1.1	1.4	1.4	-0.5	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.6	-0.8	-1.0	-1.2	-0.8	-0.4	-0.8	-0.2	-1.0	-1.6	0.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	3.9	-0.4	-0.3	-0.3	-0.5	1.1	-0.1	0.1	1.0	0.2	0.4	-2.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.9	0.6	0.8	0.4	0.6	0.6	-0.4	0.7	1.7	1.0	-0.5	-0.7
Headache pain in last month	0.5	0.9	2.0	-1.4	-1.0	-1.3	-1.1	-0.6	0.5	-1.1	-0.8	-0.8	1.1	-0.3
Leg fat percentage (right)	0.5	1.7	2.5	1.5	1.6	1.6	1.6	0.5	-1.3	1.5	1.3	0.2	-1.1	-1.3
Qualifications: College or University degree	0.5	1.6	7.8	0.8	0.9	0.7	1.1	2.8	-0.4	0.3	2.4	0.4	-1.0	-0.3
Medication: Ibuprofen	0.5	0.6	2.7	-0.4	-0.3	-0.1	-0.4	1.5	0.1	-0.0	0.9	0.1	0.4	-1.6
Medication: Allopurinol	0.5	0.6	1.7	1.1	0.6	1.0	0.8	1.3	-0.6	0.2	-0.1	0.2	-0.9	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.1	0.3	0.6	0.3	0.3	-0.5	-1.0	1.4	1.1	0.1	-0.4	-1.0
Smoking status: Previous	0.5	0.7	1.7	1.2	0.8	0.5	0.9	1.3	-0.6	0.6	0.5	1.1	-0.8	0.3
Ever had bowel cancer screening	0.5	0.6	1.3	1.1	1.1	1.0	0.9	-0.3	-0.6	0.5	0.7	0.6	-0.7	-0.1
Friendships satisfaction	0.5	0.6	1.3	0.4	0.9	0.8	1.0	0.3	-0.3	1.0	1.2	0.7	-0.8	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.5	0.6	0.6	1.2	0.8	-1.0	-0.7	-0.2	-0.8	-0.3	-0.9	0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	0.6	0.8	0.8	0.5	-0.6	-0.8	0.6	-0.7	0.6	-0.7	1.4
Mother’s age at death	0.5	0.6	4.3	-0.6	-0.4	-0.2	-0.4	0.8	-0.2	0.0	1.1	0.1	0.4	-2.1
Leg fat percentage (left)	0.5	1.7	2.6	1.5	1.6	1.6	1.6	-0.1	-1.6	1.4	1.1	-0.2	-1.1	-1.4
Waist Hip Ratio (WHR)	0.4	1.8	3.1	-1.7	-1.7	-1.8	-1.4	0.5	0.5	-1.4	-1.5	-1.3	1.4	-0.5
Systolic Blood Pressure	0.4	2.0	7.3	-1.5	-1.1	-1.6	-1.3	-0.6	0.4	-0.9	-2.0	-1.2	0.8	2.7
Average weekly spirits intake	0.4	0.5	3.9	-0.0	0.2	-0.1	0.0	0.3	0.2	-0.3	-0.5	-0.7	-0.2	2.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.1	0.3	0.2	0.2	0.4	0.8	-1.5	0.6	0.2	-1.1	-0.5	-0.1
Medication for hormone replacement therapy	0.4	0.5	3.1	0.2	-0.1	-0.3	-0.1	1.2	0.4	0.2	-0.4	0.3	0.0	1.8
Taking other prescription medications	0.4	0.6	3.0	-0.8	-0.4	-0.6	-0.5	1.7	0.7	-0.3	0.9	0.4	0.6	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.5	0.6	0.1	0.2	0.2	0.9	-1.2	1.2	0.3	-0.4	-0.4	-0.7
Impedance of arm (right)	0.4	1.8	7.0	-1.5	-1.3	-1.0	-1.3	0.8	2.7	-1.6	-0.0	0.9	1.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	5.9	-0.3	-1.1	-1.0	-1.2	-2.4	0.4	-1.3	-1.5	-1.1	1.0	0.4
Medication: Cholesterol lowering	0.4	0.7	3.4	0.6	0.4	0.5	0.3	-0.0	-0.4	-0.6	-1.4	-0.6	-0.5	1.8
Impedance of arm (left)	0.4	1.7	6.4	-1.5	-1.2	-0.9	-1.2	0.5	2.5	-1.9	0.3	0.4	1.2	-0.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	1.1	1.0	0.9	0.8	0.2	-0.2	0.4	0.6	0.8	-0.7	0.2
Blood clot in the leg (DVT)	0.4	0.5	1.9	-0.6	-0.6	-0.8	-0.8	-1.4	-0.5	-0.7	-0.5	-0.2	0.7	-0.3
Medication: Amlodipine	0.4	0.6	1.6	0.8	1.0	0.7	0.6	-1.0	-0.4	0.5	-0.7	-0.2	-0.8	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.2	-0.7	-0.8	-0.7	-0.4	0.9	-0.8	-1.1	-0.2	0.8	0.9
Neck or shoulder pain in last month	0.4	0.6	1.5	0.5	0.8	0.9	0.6	-0.8	-0.3	0.6	0.7	1.2	-0.6	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	0.7	0.9	0.7	0.9	-0.6	-1.0	0.3	0.6	-0.5	-0.8	-0.3
Family relationship satisfaction	0.4	0.5	1.3	-0.5	-0.7	-1.0	-0.5	1.2	0.8	-0.2	-0.4	-0.6	0.9	0.1
Long-standing illness, disability or infirmity	0.4	0.7	5.1	-0.9	-0.0	-0.3	-0.1	2.3	0.3	-0.1	0.6	0.4	0.1	0.7
Back pain experienced in last month	0.4	0.5	1.4	0.2	0.6	0.6	0.7	1.2	-0.4	1.1	0.9	0.5	-0.7	0.4
Guilty feelings	0.4	0.7	1.8	-0.7	-0.8	-1.1	-0.7	1.3	1.2	-0.2	0.1	-0.4	1.0	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.7	0.5	0.4	0.4	0.7	0.6	-1.3	0.5	0.6	-1.1	-0.7	0.5
Ever smoked	0.4	0.7	3.4	-0.1	-0.3	-1.0	-0.2	1.8	-0.3	0.1	-0.9	-0.9	0.4	1.0
Supplements: Calcium	0.4	0.4	2.8	-0.2	-0.4	-0.5	-0.3	-0.5	-0.2	-0.5	-0.0	-0.7	0.6	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.3	-0.7	-0.6	-0.8	-0.8	-1.5	-0.4	-0.7	-0.4	-0.1	0.8	-0.5
Depressed Affect (Nagel 2018)	0.3	0.5	1.0	-0.7	-0.6	-0.8	-0.7	0.7	0.3	-1.0	-0.5	-0.6	0.9	-1.0
Neuroticism (Nagel 2018)	0.3	0.7	2.5	-0.6	-0.5	-0.8	-0.6	0.4	1.6	-0.6	-0.8	0.3	0.9	1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	2.5	-1.6	0.0	-1.3	0.0	-0.2	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.3	0.5	1.9	1.1	0.9	1.4	1.0	-0.5	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.3	0.4	3.7	0.6	0.3	0.4	0.3	-1.9	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.3	0.4	2.5	0.0	-0.3	-0.4	-0.2	-0.1	0.7	-0.5	-1.6	-0.2	0.3	0.8
Triglycerides	0.3	0.5	1.6	-1.3	-1.0	-1.3	-1.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	-1.0	0.0	-1.0	0.0	-1.1	0.0	0.0	0.0	0.0	0.0	0.0
Relative age of first facial hair	0.3	0.6	2.2	1.5	0.7	0.7	0.7	-0.3	-0.2	0.4	0.8	1.1	-0.6	-0.0
Pack years adult smoking proportion	0.3	0.5	1.1	-0.3	-0.7	-0.8	-0.7	0.6	1.0	-1.1	-0.5	-0.4	1.0	0.1
Trunk fat percentage	0.3	1.3	2.8	1.3	1.2	1.7	1.2	-0.2	-0.7	0.9	1.4	0.9	-0.9	-1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.5	0.8	0.4	0.1	0.4	0.4	-0.7	1.2	0.3	0.5	-0.4	0.1
Qualifications: None of the above	0.3	0.6	3.3	-0.0	-0.2	-0.2	-0.3	-1.8	-0.3	0.2	-1.5	-0.2	0.3	0.6
Mouth/teeth dental problems	0.3	0.4	1.1	0.7	0.4	0.9	0.2	-0.5	0.5	-0.2	-0.2	1.1	-0.3	1.0
Prospective memory result	0.3	0.4	1.0	0.5	0.6	0.5	0.5	-0.5	-0.6	1.0	0.7	0.3	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.9	-0.1	-0.9	-1.0	-1.0	-2.0	-0.1	-0.9	-1.4	-1.3	0.7	0.7
Length of working week for main job	0.3	0.3	1.2	-0.1	-0.3	-0.6	-0.3	-0.5	0.0	-0.7	-1.1	-1.0	0.3	0.5
Peak expiratory flow (PEF)	0.3	0.8	1.9	1.2	0.5	0.7	0.5	-0.8	-1.4	0.9	0.9	0.3	-0.7	-1.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	3.8	-0.2	-0.4	-0.5	-0.1	1.9	0.2	-0.8	0.2	-0.4	0.3	-0.6
Gout (self-reported)	0.3	0.4	1.1	0.9	0.4	0.8	0.5	1.1	-0.2	0.2	-0.1	0.6	-0.6	0.9
Body fat percentage	0.3	1.3	2.5	1.3	1.2	1.6	1.2	-0.2	-0.9	1.0	1.3	0.6	-0.8	-1.5
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.5	-0.1	-0.2	-0.3	-1.1	0.7	-0.0	-0.7	0.8	0.3	0.6
Number of full brothers	0.3	0.4	1.0	-1.0	-0.4	-0.5	-0.5	0.5	0.5	-0.3	-1.0	-0.7	0.6	0.7
Worry too long after embarrassment	0.3	0.4	1.7	0.2	0.3	0.5	0.5	-0.6	1.0	0.2	0.4	0.9	-0.2	1.3
Number of children fathered	0.3	0.4	1.9	-0.5	-0.3	-0.3	-0.3	0.8	-0.3	0.6	-0.7	0.3	0.2	1.4
Mean time to correctly identify matches	0.3	0.5	2.7	-0.3	-0.1	0.1	-0.2	0.9	1.6	-0.7	0.7	0.9	0.4	-0.1
Medication: Aspirin	0.3	0.4	3.2	-0.3	-0.0	-0.2	0.1	1.0	-0.1	0.4	-0.3	-0.2	0.1	1.8
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-1.0	-0.3	-0.8	-0.6	0.7	0.3	0.2	0.8	0.4	0.7	-0.8
Medication: Aspirin	0.3	0.4	3.1	-0.3	0.1	-0.1	0.2	0.7	-0.0	0.5	-0.3	-0.0	0.0	1.8
Ever taken oral contraceptive pill	0.3	0.4	1.7	-0.5	-0.0	-0.1	-0.1	0.9	-0.0	-0.1	1.0	0.5	0.0	-1.3
Medication: Paracetamol	0.3	0.4	0.8	-0.8	-0.7	-0.6	-0.6	0.9	0.9	0.1	-0.1	0.6	0.8	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	0.5	0.5	0.6	0.5	-0.8	-0.1	-0.3	1.2	-0.2	-0.5	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.7	0.6	0.4	0.5	0.5	-0.8	0.9	0.4	-0.2	-0.6	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.9	-0.6	-0.8	-0.4	-0.6	0.8	0.9	-0.8	-0.4	0.1	0.6	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.6	0.5	0.4	0.3	0.3	0.2	-0.9	0.8	1.4	0.8	-0.6	-1.9
Heart disease (siblings)	0.3	0.4	1.0	-0.2	-0.5	-0.1	-0.4	-0.7	0.9	-0.8	-1.0	-0.7	0.6	0.2
Alcohol drinker status: Previous	0.3	0.3	0.7	0.8	0.5	0.1	0.5	0.4	-0.9	0.7	-0.0	-0.6	-0.6	0.6
Pack years of smoking	0.3	0.4	1.3	-0.1	-0.6	-0.7	-0.6	0.1	0.7	-1.1	-0.6	-0.6	0.9	0.0
Depression (Nagel 2018)	0.2	0.2	1.4	0.4	-0.1	-0.2	-0.1	0.4	1.2	-0.4	0.5	0.6	0.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.1	0.5	0.7	0.5	0.9	0.5	-0.6	0.3	1.4	-0.6	-0.7	-0.4
Ovarian Cancer	0.2	0.3	0.9	0.2	0.4	0.4	0.4	0.5	0.0	0.5	0.6	1.0	-0.5	0.6
Blood Eosinophil Count	0.2	1.6	6.9	-0.5	-0.1	0.2	-0.2	-2.1	1.8	-0.0	-1.3	1.1	0.5	2.6
Chronotype (morning person)	0.2	0.4	0.7	-0.4	-0.5	-0.5	-0.4	0.8	0.8	-0.9	-0.6	0.3	0.6	-0.6
Number of treatments/medications taken	0.2	0.3	1.1	-0.9	-0.3	-0.4	-0.2	0.4	0.5	-0.3	-0.3	-0.5	0.3	1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	0.1	0.6	0.1	0.4	0.2	-1.0	-0.5	0.6	-0.7	-0.7	-0.1
Systolic blood pressure, automated reading	0.2	0.6	2.8	0.1	0.4	-0.0	0.4	-0.9	-1.7	0.7	-0.2	-1.1	-0.6	0.5
Diabetes (mother)	0.2	0.2	1.0	-0.3	0.3	-0.0	0.1	0.6	-0.7	1.0	0.2	0.1	-0.2	0.5
Severe depression (siblings)	0.2	0.2	0.9	0.4	0.4	0.3	0.4	0.9	0.3	0.1	0.5	0.1	-0.3	0.4
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.2	-0.5	-0.6	-0.5	0.3	0.6	-0.1	-0.5	-0.3	0.6	0.4
Body mass index (BMI)	0.2	0.7	1.8	1.0	0.7	0.9	0.7	0.5	-1.1	1.4	0.5	0.4	-0.4	-1.1
Waist circumference	0.2	0.8	3.6	0.7	0.5	0.6	0.5	0.2	-1.4	0.8	0.7	-0.3	-0.4	-1.9
Past tobacco smoking	0.2	0.3	2.4	-0.5	-0.1	0.4	-0.2	-1.6	0.1	-0.2	0.5	-0.2	-0.0	-0.7
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.7	-0.8	-0.5	-0.6	0.5	0.8	-0.5	-0.1	0.1	0.6	-0.0
Time employed in main current job	0.2	0.2	1.2	-0.1	0.0	0.2	0.1	0.5	1.1	-0.5	-0.2	0.6	0.0	0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.7	-0.2	-0.1	-0.2	-0.2	-0.9	-0.2	0.0	-0.8	-0.2	0.1	1.3
Worrier / anxious feelings	0.2	0.4	1.0	0.2	0.5	0.5	0.5	-0.6	1.0	0.3	0.6	1.0	-0.2	0.9
Number of live births	0.2	0.3	1.2	0.1	0.7	0.4	0.3	-0.4	-1.1	0.2	0.1	-0.8	-0.6	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	1.3	-0.2	-0.1	-0.3	0.1	0.6	0.3	1.2	0.2	0.1	0.2	0.4
Standing height	0.2	1.6	5.9	-0.7	-1.6	-0.8	-1.2	-0.4	2.0	-2.4	-0.8	-0.4	1.0	0.9
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.3	0.0	-0.1	0.2	0.9	-0.8	0.8	-0.3	-0.4	-0.2	0.1
Birth weight	0.2	0.4	2.0	1.4	0.2	1.2	0.5	0.1	0.4	-0.5	-0.0	0.7	-0.5	-0.2
Pulse wave peak to peak time	0.2	0.3	1.5	0.3	0.2	0.3	-0.0	-0.6	-0.5	-1.2	-0.2	-0.3	-0.3	-0.5
Alcohol intake frequency.	0.2	0.4	1.4	-0.0	0.0	-0.3	-0.2	-1.2	-0.6	0.8	-0.9	0.2	-0.0	1.2
Comparative height size at age 10	0.2	1.0	3.8	-0.6	-0.8	-0.6	-0.7	-2.0	0.2	-1.4	-1.1	-1.1	0.5	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.6	-0.1	-0.1	-0.1	-0.1	-0.4	-0.7	-0.1	-0.6	-1.2	0.1	-0.7
Supplements: Vitamin C	0.2	0.2	1.0	-1.0	-0.4	-0.3	-0.3	0.5	0.2	-0.7	-0.2	-0.2	0.4	-0.5
Illnesses of father: Heart disease	0.2	0.3	1.2	0.2	0.2	0.0	0.4	0.9	0.1	0.8	1.1	0.4	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.5	-0.5	0.1	-0.2	0.2	0.8	0.1	0.6	1.0	0.3	0.0	-1.2
Osteoporosis (self-reported)	0.2	0.3	0.9	0.2	0.4	0.4	0.4	-0.8	0.1	-0.5	-0.8	-0.1	-0.3	0.9
Smoking status: Current	0.2	0.3	1.8	-0.3	-0.1	-0.5	-0.1	-0.2	0.0	0.3	-0.4	-1.3	0.3	0.8
Medication: Bendroflumethiazide	0.2	0.3	2.0	0.1	0.3	0.0	0.5	0.6	-0.1	0.2	-0.1	-0.6	-0.2	1.4
Medication: Lisinopril	0.2	0.3	2.3	0.3	0.3	0.3	0.4	1.5	0.5	-0.3	0.4	-0.0	-0.1	0.4
Ever depressed for a whole week	0.2	0.3	1.2	0.0	-0.2	-0.3	-0.2	1.1	-0.0	0.3	-0.8	-0.1	0.2	1.0
Unable to work because of sickness or disability	0.2	0.2	0.7	-0.1	-0.6	-0.5	-0.6	-0.2	0.2	-0.1	-0.8	-0.1	0.6	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.4	0.5	0.1	0.4	0.5	0.7	-0.5	-0.1	1.2	-0.6	-0.3	-1.1
Major Depression (MDD)	0.1	0.1	0.5	0.7	0.6	0.5	0.5	-0.1	0.0	-0.2	-0.3	0.1	-0.3	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	2.2	0.2	0.0	-0.0	-0.1	1.5	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.1	0.9	3.0	0.5	0.3	0.5	0.2	1.7	0.2	1.5	0.7	1.7	0.2	-0.2
Height	0.1	1.4	8.3	0.2	-1.1	-0.3	-0.6	-1.0	1.4	-2.9	-0.9	-0.9	0.5	0.4
Smoking Status	0.1	0.3	0.7	0.8	0.5	0.2	0.6	0.4	-0.5	0.6	-0.4	-0.6	-0.5	0.8
Cardiovascular Disease	0.1	0.2	1.3	-0.1	-0.2	-0.1	-0.2	-0.2	0.3	-0.2	-0.5	-1.2	0.2	0.2
Tanning	0.1	1.3	2.5	-0.8	-1.6	-1.3	-1.5	-1.0	0.8	-0.8	-1.4	0.1	1.6	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.6	0.1	0.1	0.3	0.2	-0.1	0.0	0.8	0.1	0.8	-0.1	0.7
Hearing difficulty/problems: Yes	0.1	0.2	0.8	0.3	-0.1	-0.0	-0.0	-0.2	-0.7	-0.3	-0.4	-0.9	-0.0	-0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.7	0.1	0.4	0.0	0.4	-0.1	-0.0	0.3	0.2	0.8	-0.1	0.6
Impedance of leg (right)	0.1	0.4	1.3	-0.7	-0.2	-0.3	-0.2	-0.8	1.2	-1.1	0.2	-0.8	0.2	0.3
Leg fat-free mass (left)	0.1	0.6	1.3	-0.1	-1.1	-0.5	-0.9	0.5	1.1	-0.6	-0.8	0.6	1.1	0.1
Current tobacco smoking	0.1	0.2	1.5	0.0	0.1	-0.3	0.1	0.3	-0.2	0.5	-0.1	-1.2	0.1	0.8
High blood pressure	0.1	0.3	1.2	-0.0	-0.1	-0.1	-0.0	-0.5	0.4	-0.4	-0.8	-0.8	0.2	1.1
Impedance of leg (left)	0.1	0.7	3.2	-0.5	0.1	-0.0	0.1	-1.8	0.4	-1.3	-0.1	-1.5	-0.2	0.1
Leg predicted mass (left)	0.1	0.6	1.2	-0.1	-1.1	-0.5	-0.8	0.6	1.1	-0.6	-0.8	0.6	1.0	0.2
Trunk fat mass	0.1	0.6	1.4	1.1	0.7	1.2	0.7	-0.1	-0.5	0.4	0.8	0.4	-0.4	-1.1
Arm fat percentage (right)	0.1	0.3	2.1	0.5	0.3	0.6	0.3	0.2	-0.4	0.6	0.4	0.5	0.1	-1.4
Hip circumference	0.1	0.6	2.4	0.8	0.4	0.8	0.4	0.3	-0.4	0.6	1.1	0.5	-0.2	-1.6
Depression (self-reported)	0.1	0.1	0.5	0.2	-0.2	-0.4	-0.3	0.2	0.1	0.4	0.1	0.2	0.3	-0.7
Illnesses of mother	0.1	0.2	0.6	-0.0	0.1	-0.1	0.3	0.3	0.0	0.7	0.8	0.7	-0.2	0.2
Arm fat mass (right)	0.1	0.3	0.7	0.9	0.4	0.8	0.5	0.0	-0.7	0.7	0.2	0.2	-0.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.3	-0.5	-1.0	-0.4	0.4	0.1	-0.1	0.3	-0.5	0.5	-0.5
Birth weight of first child	0.1	0.2	0.7	0.7	-0.1	-0.1	0.2	-0.8	-0.1	0.1	-0.6	-0.1	-0.0	0.5
Medication: Paracetamol	0.1	0.2	0.6	-0.5	-0.3	-0.4	-0.3	0.8	0.5	0.2	0.6	0.6	0.5	-0.2
Health satisfaction	0.1	0.2	1.5	-0.0	0.3	0.1	0.1	0.3	0.3	0.2	0.1	0.5	-0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	1.0	0.5	0.3	0.2	0.2	1.0	-0.1	-0.4	0.3	-0.2	-0.2	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	1.5	0.5	0.2	0.2	0.1	-1.2	0.2	-0.3	-0.7	0.0	-0.2	0.2
Whole body fat mass	0.1	0.4	1.0	0.9	0.6	1.0	0.6	-0.2	-0.4	0.5	0.5	0.3	-0.3	-0.9
Leg fat mass (right)	0.1	0.5	1.1	1.0	0.7	0.9	0.8	0.3	-0.9	0.8	0.4	-0.2	-0.4	-0.9
Hypertension (Self-reported)	0.1	0.3	1.0	0.0	-0.1	-0.1	-0.1	-0.1	0.6	-0.7	-0.7	-1.0	0.3	0.8
Leg fat-free mass (right)	0.1	0.5	1.1	-0.1	-1.1	-0.4	-0.9	0.0	0.8	-0.8	-1.1	0.3	0.9	0.2
Arm fat percentage (left)	0.1	0.4	2.3	0.6	0.4	0.8	0.4	0.1	-0.5	0.6	0.6	0.4	-0.0	-1.5
Loneliness, isolation	0.1	0.1	0.8	-0.3	-0.1	-0.1	-0.0	0.3	0.2	0.3	0.5	0.1	0.1	-0.9
Leg predicted mass (right)	0.1	0.6	1.3	-0.2	-1.1	-0.5	-0.9	0.0	0.8	-0.8	-1.1	0.3	1.0	0.2
Arm fat mass (left)	0.1	0.3	1.1	0.8	0.4	0.8	0.4	-0.0	-0.6	0.5	0.3	0.1	-0.2	-1.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.8	-0.0	0.2	-0.3	0.1	0.4	-0.5	-0.1	0.9	-0.3	-0.1	-0.3
Diastolic blood pressure, automated reading	0.1	0.4	1.3	0.8	0.2	0.3	0.2	-1.1	1.1	0.7	-0.1	-0.2	-0.0	0.9
Myopia	0.1	0.2	0.5	0.3	-0.3	-0.6	-0.5	-0.3	0.5	-0.7	-0.6	0.2	0.3	0.3
Pain experienced in last month	0.1	0.2	1.0	0.1	-0.3	-0.2	-0.1	0.8	0.6	-0.3	-0.2	-0.0	0.2	1.0
Impedance of whole body	0.1	0.7	3.1	-0.9	-0.5	-0.4	-0.5	-0.6	1.8	-1.5	0.3	-0.1	0.5	0.2
Leg fat mass (left)	0.1	0.5	1.0	1.0	0.7	0.9	0.8	0.0	-1.0	0.7	0.3	-0.4	-0.4	-0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.3	1.3	-0.3	-0.7	-0.5	-0.4	0.1	-0.2	-1.1	-0.8	-0.2	0.3	0.4
Sitting height	0.0	0.2	1.3	0.3	-0.2	0.1	0.1	0.6	0.1	0.2	1.1	0.5	-0.1	0.1
Weight	0.0	0.1	0.6	0.7	0.0	0.5	0.1	0.1	-0.2	0.2	0.1	0.2	0.1	-0.8
Trunk fat-free mass	0.0	0.2	0.7	0.3	-0.6	-0.2	-0.4	-0.4	0.1	-0.6	-0.8	-0.5	0.4	0.1
Trunk predicted mass	0.0	0.2	0.7	0.3	-0.6	-0.2	-0.4	-0.3	0.1	-0.6	-0.8	-0.5	0.4	0.2
Arm fat-free mass (right)	0.0	0.2	1.0	1.0	0.2	0.4	0.3	-0.6	-0.7	0.1	-0.1	-0.6	-0.3	-0.3
Arm predicted mass (right)	0.0	0.2	0.6	0.8	0.0	0.4	0.2	-0.7	-0.5	-0.2	-0.3	-0.6	-0.1	-0.4
Whole body fat-free mass	0.0	0.3	0.7	0.2	-0.8	-0.3	-0.6	-0.2	0.3	-0.7	-0.8	-0.2	0.6	0.1
Whole body water mass	0.0	0.3	0.8	0.1	-0.8	-0.3	-0.6	-0.1	0.4	-0.6	-0.9	-0.2	0.7	0.0
Basal metabolic rate	0.0	0.2	0.6	0.2	-0.7	-0.2	-0.5	-0.2	0.3	-0.6	-0.8	-0.3	0.6	-0.2
Arm fat-free mass (left)	0.0	0.2	0.8	0.9	0.1	0.4	0.3	-0.4	-0.6	0.1	-0.4	-0.4	-0.2	-0.1
Arm predicted mass (left)	0.0	0.2	0.8	0.9	0.1	0.4	0.3	-0.6	-0.5	0.1	-0.2	-0.2	-0.2	-0.0

Hub : Genes

LRCH4

Models

Trait associations