Hub : Genes

LRP2BP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2210 0.0380 9.8e-12 0.162 0.123 0.201 0.218 0.206 2.8e-19 1.0e-14 6.0e-24 4.8e-26 1.6e-24
2 GTEx Artery Aorta 0.2740 0.0780 1.6e-03 0.094 NA 0.110 NA 0.116 7.3e-06 NA 1.2e-06 NA 6.4e-07
3 GTEx Cells EBV-transformed lymphocytes 0.4700 0.1030 6.2e-04 -0.009 NA -0.009 NA -0.009 9.9e-01 NA 9.7e-01 NA 8.4e-01
4 GTEx Lung 0.1625 0.0466 2.7e-04 0.001 NA 0.019 NA 0.014 2.5e-01 NA 1.2e-02 NA 2.8e-02
5 GTEx Nerve Tibial 0.2206 0.0550 1.3e-04 0.064 NA 0.219 NA 0.177 2.6e-05 NA 1.8e-15 NA 1.4e-12
6 GTEx Skin Not Sun Exposed Suprapubic 0.2210 0.0740 3.9e-03 0.007 NA 0.007 NA 0.013 1.3e-01 NA 1.3e-01 NA 6.4e-02
7 GTEx Skin Sun Exposed Lower leg 0.1500 0.0490 6.6e-04 0.001 NA 0.027 NA 0.006 2.5e-01 NA 2.3e-03 NA 8.6e-02
8 GTEx Testis 0.7920 0.0580 1.4e-12 0.547 NA 0.391 NA 0.528 1.9e-28 NA 1.6e-18 NA 4.3e-27
9 METSIM Adipose 0.0609 0.0296 2.2e-02 0.002 0.007 -0.001 0.014 0.001 1.6e-01 2.6e-02 5.1e-01 3.2e-03 2.3e-01
10 NTR Blood 0.0652 0.0145 1.3e-11 0.053 0.043 0.047 0.043 0.053 1.2e-16 9.8e-14 4.7e-15 7.8e-14 1.0e-16
11 ROSMAP Brain Pre-frontal Cortex 0.3689 0.0429 0.0e+00 0.179 0.198 0.316 0.260 0.303 2.1e-22 7.5e-25 2.0e-41 3.0e-33 1.5e-39
12 TCGA Esophageal Carcinoma 0.1090 0.0610 6.5e-03 0.055 0.023 -0.001 NA 0.007 8.0e-03 6.1e-02 3.4e-01 NA 1.8e-01
13 TCGA Head and Neck Squamous Cell Carcinoma 0.0429 0.0249 7.6e-03 0.018 0.002 0.013 NA 0.005 3.5e-03 1.9e-01 1.1e-02 NA 9.0e-02
14 TCGA Brain Lower Grade Glioma 0.0898 0.0320 5.1e-09 0.049 0.088 0.077 NA 0.073 3.0e-06 3.7e-10 4.8e-09 NA 1.0e-08
15 TCGA Lung Adenocarcinoma 0.0232 0.0141 5.0e-03 0.000 0.009 0.007 NA 0.004 2.9e-01 2.4e-02 4.6e-02 NA 9.4e-02
16 TCGA Thyroid Carcinoma 0.0750 0.0350 6.0e-06 0.049 0.045 0.041 NA 0.053 1.5e-05 3.0e-05 6.8e-05 NA 6.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.4 0.7 3.0 0.8 0.3 -1.0 0.4 1.7 -0.2 0.1 -0.5 0.8 -0.5 0.9 0.9 1.2 1.1 0.3 0.4
Bipolar Disorder or Schizophrenia 0.3 0.7 2.5 0.5 0.1 -0.3 1.0 0.3 0.8 -0.2 0.5 1.0 -1.6 0.3 1.5 0.9 0.3 0.7 0.9
Depressed Affect (Nagel 2018) 0.1 0.3 1.3 0.2 -0.7 -0.0 -0.5 -0.1 -0.3 -1.1 0.8 -0.3 0.1 0.7 -0.5 -0.1 -0.5 -0.2 -0.9
Depression (Nagel 2018) 0.3 0.5 1.9 0.5 -1.2 0.1 0.2 -0.6 -0.3 -0.8 0.7 -1.4 -0.9 1.0 -0.6 0.5 -0.3 -0.4 -0.7
Intelligence (Savage-Jansen 2018) 0.9 2.7 7.8 -1.3 -2.8 -2.1 -1.0 -2.5 -0.5 -1.8 0.6 0.1 1.6 -1.8 -1.5 -0.6 -1.7 -1.7 -1.7
Neuroticism (Nagel 2018) 0.3 0.7 2.8 -0.2 0.5 -0.2 -1.5 1.3 -0.0 0.8 0.4 0.3 1.7 1.0 -0.7 0.6 0.0 -0.4 -1.2
Schizophrenia (2018) 0.3 0.6 2.7 -0.0 -0.1 0.4 1.0 -1.1 1.2 -0.4 0.8 0.5 -1.6 -0.3 1.2 0.2 -0.4 0.7 0.8
Schizophrenia vs Biploar Disorder 0.6 0.8 3.4 0.9 0.6 0.6 -0.1 1.2 1.1 0.7 -0.5 -0.1 0.3 0.3 1.7 -0.1 0.6 1.8 1.3
Worry (Nagel 2018) 0.5 1.1 4.7 0.8 0.2 0.0 -2.1 1.3 -0.5 1.2 -0.5 0.2 2.2 1.0 -0.6 0.3 0.8 -0.5 -1.3
Alzheimer’s Disease (in mother) 0.3 0.3 1.6 -0.3 -0.2 0.5 -0.6 -0.8 -0.4 -0.2 0.0 -0.6 0.2 0.0 -1.2 -0.1 -0.1 -0.9 -0.6
Alzheimer’s Disease (in father) 0.9 1.0 2.3 1.2 -0.9 -0.4 -1.3 0.9 -0.8 -0.9 0.7 -0.4 1.4 1.5 -0.8 1.5 0.6 -0.9 -1.1
Alzheimer’s Disease (including proxy) 0.5 0.8 2.4 1.1 -0.3 1.0 -0.8 0.7 -0.4 -0.1 0.3 -0.5 0.9 1.5 -1.1 1.5 0.7 -0.8 -0.7
Crohns Disease (2017) 0.4 0.8 4.3 1.0 -0.7 -0.9 -0.5 1.3 0.5 0.0 1.8 0.3 -0.4 0.8 0.1 2.1 0.1 -0.0 -0.5
Irritable Bowel Disease (IBD) 0.4 1.0 2.8 -0.2 -1.4 -0.2 -0.1 -0.4 -1.2 -1.1 1.3 -0.7 0.2 -0.4 -1.7 0.5 -0.7 -1.5 -1.6
Ulcerative Colitis (UC) 0.9 1.7 5.2 -0.8 -1.3 1.0 0.1 -1.2 -2.1 -1.5 0.5 -0.9 0.5 -0.9 -2.3 -0.7 -0.7 -2.1 -1.9
Major Depression (MDD) 0.8 0.9 2.7 -0.2 1.4 0.5 1.6 -0.2 0.6 1.5 -0.8 -1.3 -1.3 0.1 0.9 0.4 0.6 0.8 1.1
Reaction Time 0.5 0.9 4.3 -0.1 1.3 -1.0 -0.5 0.7 -0.4 -0.1 -0.8 -0.5 1.0 0.5 -1.4 0.5 0.6 -1.3 -2.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 4.8 -0.5 -2.2 -0.9 0.4 -1.2 -0.3 -0.9 0.0 -0.7 -0.5 -1.1 -0.5 -0.4 -0.7 -0.5 -0.8
Breast Cancer 0.3 0.6 1.9 1.4 0.7 -0.5 -0.6 0.7 0.8 -0.6 -1.2 -0.8 -0.4 1.1 -0.1 -0.5 1.3 0.4 0.3
Ovarian Cancer 0.7 1.0 5.9 0.5 0.3 1.1 -0.3 -0.0 -0.6 -0.9 -2.0 -0.2 -0.2 0.4 0.6 -2.4 1.2 0.7 0.3
Prostate Cancer 0.3 0.4 1.7 0.6 0.1 0.3 0.9 0.1 0.9 -0.0 0.4 0.7 0.1 -0.3 1.3 0.1 0.3 1.3 0.7
Age at First Birth 0.8 1.2 5.7 -1.4 -0.6 -0.3 -0.3 -1.5 0.4 -0.9 -0.3 0.3 1.3 -1.9 0.2 -2.4 -1.4 0.4 0.6
Bipolar Disorder (2011) 0.6 0.6 3.3 0.1 1.6 0.5 0.2 1.3 -0.8 0.4 -0.1 1.8 -0.4 0.5 0.3 0.6 0.7 0.1 -0.4
Body Mass Index (BMI) (2010) 0.2 0.3 1.3 0.5 -0.4 -0.9 0.5 0.5 -0.4 -0.3 0.6 -0.7 0.8 0.6 0.1 1.1 0.2 -0.2 -0.3
Coronary Artery Disease (CAD) 1.9 2.2 10.2 -0.8 -1.2 -0.9 2.2 -1.0 2.2 0.2 1.0 1.2 -3.2 -1.8 1.0 -1.4 -1.4 0.7 0.6
Crohns Disease (2012) 1.0 1.5 3.2 0.9 -1.7 -1.6 -1.7 -0.2 -1.7 -1.8 1.2 -1.0 0.7 1.0 -1.2 0.8 -0.0 -1.1 -1.4
Mean Putamen Volume 0.4 0.5 1.6 -0.6 -1.2 1.3 -0.2 -0.6 -0.8 -0.7 -0.2 0.1 0.3 -0.7 -0.9 -0.4 -0.6 -0.8 -0.4
Fasting Glucose 0.6 0.7 3.3 -0.7 0.3 -1.2 -1.8 0.6 0.2 0.4 -1.2 0.5 1.2 -0.3 -0.4 0.3 0.4 -0.7 -1.0
HbA1C 0.2 0.2 1.1 -0.6 -0.1 -0.1 -1.0 0.5 0.3 -0.5 -0.3 -1.0 0.2 0.2 -0.2 0.1 -0.1 -0.3 0.0
HDL Cholesterol 0.4 0.6 2.1 0.1 -1.4 -0.2 -1.1 0.2 -0.9 -1.1 -0.8 -0.2 -0.0 -0.5 -0.6 0.5 0.2 -1.4 -1.1
LDL Cholesterol 0.4 0.7 2.1 -1.2 -0.5 0.5 0.6 -1.4 0.4 -0.4 0.6 0.1 -0.3 -1.4 -0.1 -1.2 -1.3 0.2 0.5
Lupus 1.3 1.9 4.7 -1.7 -1.7 -0.7 0.3 -2.2 -1.0 -1.8 1.9 -0.8 -0.2 -1.3 -1.1 -2.0 -1.9 -0.7 -0.5
Neuroticism (2016) 1.3 1.8 6.1 -0.7 -0.8 0.6 -1.3 -1.4 -1.6 -0.5 0.6 -1.4 0.9 -0.0 -2.5 -0.7 -0.9 -2.3 -2.4
Primary Biliary Cirrhosis 0.5 0.6 4.3 0.8 0.7 2.1 -0.2 1.0 0.2 0.7 0.0 0.1 -0.4 0.7 1.0 0.0 0.5 1.0 0.6
Rheumatoid Arthritis 0.3 0.4 1.3 0.7 0.5 -0.7 0.9 1.1 0.7 0.6 -0.3 -0.3 -0.5 0.6 -0.1 0.9 0.7 -0.2 -0.0
Schizophrenia (2014) 1.0 2.2 7.5 -0.1 1.0 0.3 2.0 0.3 2.1 1.0 0.2 1.7 -2.5 -0.6 2.7 0.3 -0.0 2.0 2.0
Triglycerides 0.2 0.4 1.3 -0.2 -0.4 -0.9 -0.1 -0.8 -0.7 -1.2 0.7 1.0 1.0 0.4 -0.2 -0.0 0.0 -0.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.8 1.0 5.6 -1.1 -0.0 0.7 0.8 0.0 0.5 -0.3 2.1 2.4 -0.2 -0.6 0.4 0.4 -1.4 0.1 -0.1
Ulcerative Colitis 0.7 1.0 3.0 -0.2 -1.6 -0.0 0.6 -0.5 -1.7 -1.3 -0.0 -0.8 0.8 -0.6 -1.6 -0.5 -0.5 -1.6 -1.1
Blood Eosinophil Count 0.2 1.2 4.1 -0.0 -0.0 -0.1 -1.9 0.0 -0.8 -0.5 1.2 -0.4 1.5 0.6 -1.5 1.0 -0.3 -1.7 -2.0
Blood Platelet Count 0.0 0.5 3.3 -0.2 -0.8 -0.3 -0.0 -0.9 -0.1 -0.7 -0.4 -1.8 0.6 -0.6 -0.5 -0.5 0.2 -0.7 -1.1
Blood Red Count 0.0 0.5 2.7 -0.2 -0.7 1.6 0.0 0.8 -0.5 -0.4 -0.3 -0.4 -1.5 -0.1 -0.0 0.2 -0.6 -0.2 0.4
Blood White Count 0.1 0.8 3.9 -1.3 0.5 -0.7 -0.4 -0.5 2.0 1.0 0.3 0.8 0.7 -1.2 0.8 -0.1 -0.6 0.8 1.1
Heel T-Score 0.2 1.9 6.9 0.2 1.6 0.5 1.0 1.7 0.3 2.6 -0.7 2.1 -1.5 -0.1 1.8 1.3 0.8 1.3 1.5
BMI 0.1 0.4 2.9 0.3 -0.4 -1.7 -0.1 -0.1 -0.1 -0.8 0.5 -1.0 -0.6 -0.0 0.0 1.1 -0.1 0.3 0.5
Height 0.1 2.1 8.5 2.7 0.9 1.4 -0.2 1.6 0.3 -0.1 -0.8 0.1 -2.6 2.9 0.1 1.3 1.9 0.1 -0.1
Waist Hip Ratio (WHR) 0.3 1.4 3.8 -1.8 0.4 -1.1 -0.1 -1.3 -1.0 -0.2 2.0 -0.8 0.6 -1.1 -1.6 -0.1 -1.4 -1.6 -1.6
Systolic Blood Pressure 0.3 1.6 5.0 -1.1 -1.7 2.2 1.2 -0.9 -0.9 -1.6 -0.4 -0.3 -1.5 -1.3 -0.5 -2.2 -0.8 0.4 0.8
Smoking Status 0.6 1.3 6.0 -0.3 -2.4 -2.2 -0.6 -1.6 -0.0 -1.3 0.9 -0.8 0.7 -0.8 -0.7 -0.1 -1.3 -0.8 -0.8
Allergy or Eczema 0.2 0.5 2.0 0.2 -0.0 0.5 -0.4 1.0 -0.4 0.3 -0.8 -0.1 0.9 1.0 0.3 1.4 1.3 0.0 -0.4
Cardiovascular Disease 0.2 0.6 1.8 1.1 0.5 -0.6 0.0 1.1 -0.4 -0.3 -1.3 -0.9 -0.5 1.1 0.0 -0.3 1.3 0.4 0.0
Hypothyroidism (self reported) 0.1 0.2 0.6 0.1 -0.1 0.6 0.1 0.4 -0.1 -0.2 0.1 -0.7 -0.0 -0.1 -0.6 0.8 0.0 -0.5 -0.6
Respiratory disease 1.0 2.2 6.9 2.2 1.0 -0.9 -0.6 2.0 -0.0 1.6 -1.1 -1.3 0.6 2.5 0.3 2.2 2.6 0.3 -0.3
Type 2 Diabetes (T2D) (2018) 0.2 0.4 2.6 -0.7 0.6 0.3 -0.3 -0.3 0.6 0.7 1.6 0.6 -0.5 0.0 -0.1 0.8 -0.7 -0.0 0.6
Lung FEV1/FVC ratio 0.2 0.9 4.3 -1.0 -0.0 -0.1 1.1 0.1 0.9 -0.2 2.1 2.1 -0.3 -0.5 0.4 0.7 -1.2 0.3 0.4
Lung FVC 0.6 2.8 12.4 -1.5 -3.5 1.1 1.3 -2.2 -1.4 -2.3 0.5 -1.0 0.1 -1.9 -0.2 -2.2 -2.3 0.2 0.9
Neuroticism 0.3 0.7 2.5 0.5 0.8 1.2 -0.8 1.0 -0.2 0.6 0.6 -0.6 0.2 1.3 -1.0 0.1 0.3 -0.7 -1.6
Chronotype (morning person) 0.3 0.6 1.8 1.4 0.2 0.1 -0.7 1.1 -1.0 -0.9 -0.9 0.4 0.3 1.2 0.1 -0.4 1.1 0.2 -0.5
Hair Pigment 0.2 5.7 33.3 2.2 -0.4 -2.0 -4.0 1.2 -2.0 -0.9 -2.3 -2.0 5.8 1.7 -1.5 0.8 2.4 -1.4 -1.9
Tanning 0.1 0.9 3.9 0.6 1.0 0.9 1.5 2.0 0.8 0.7 0.4 0.0 -1.2 0.8 0.3 1.2 0.9 0.4 0.5
Hand grip strength (left) 0.4 1.1 4.8 1.0 1.5 -0.7 0.1 2.2 0.5 1.6 0.3 0.5 -0.8 1.5 0.8 0.8 0.9 1.1 0.8
Number of treatments/medications taken 0.5 0.9 2.5 1.3 0.0 1.6 0.2 0.1 0.4 -0.1 -1.4 -0.9 -1.3 1.1 0.6 -0.3 1.2 1.2 1.2
Average weekly spirits intake 0.5 0.7 2.3 0.5 0.3 1.2 -1.5 1.2 -0.8 -0.3 0.8 0.0 0.4 1.5 -0.5 1.1 0.2 0.1 0.2
Sensitivity / hurt feelings 0.4 0.6 1.6 -0.7 1.2 -0.8 -0.4 0.3 -0.6 1.1 0.7 0.5 0.7 -0.5 -0.8 -0.8 -0.5 -0.7 -1.3
Frequency of depressed mood in last 2 weeks 0.9 1.3 5.0 1.4 -0.9 2.2 0.5 0.0 0.0 -0.7 0.1 -1.7 -1.7 1.7 -0.7 1.3 0.5 -0.5 -0.8
Hearing difficulty/problems: Yes 1.1 1.7 4.4 -1.9 -1.2 -0.0 1.1 -1.9 0.3 -1.2 1.3 -0.2 -1.2 -1.7 0.0 -2.1 -2.0 0.5 0.7
Relative age of first facial hair 0.3 0.7 2.6 0.2 1.0 -1.6 0.3 0.3 1.1 1.2 0.8 1.2 0.1 0.1 0.5 1.5 0.1 -0.2 -0.4
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.9 0.6 0.4 1.4 0.6 0.5 -0.8 0.3 -0.2 -0.9 -0.4 0.8 -0.6 0.3 0.4 0.1 -0.2
Ever used hormone-replacement therapy (HRT) 0.5 0.7 3.3 -0.2 -0.3 -1.8 -0.6 -0.7 -1.0 0.8 -0.4 -0.7 -1.8 -0.6 0.4 0.1 0.4 0.3 -0.7
Ever had hysterectomy (womb removed) 2.1 2.4 4.7 -1.5 0.9 1.4 2.2 -0.9 1.4 0.8 1.8 1.5 -2.1 -1.4 1.7 -1.1 -1.6 2.0 1.6
Systolic blood pressure, automated reading 0.2 0.7 3.1 -0.3 -1.2 -0.4 -1.3 -0.2 -0.6 -1.5 -0.8 0.1 0.4 -0.9 -0.1 -1.8 0.0 0.5 0.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.5 -0.1 -0.7 -1.1 -0.2 -1.0 -1.0 -0.3 -0.4 -0.4 -0.4 -0.2 -1.6 0.3 -0.2 -1.2 -1.2
Angina 0.3 0.4 1.5 -0.5 0.0 -1.0 0.2 -0.7 1.2 0.7 0.3 0.3 -0.7 -1.1 0.7 -0.0 -0.2 0.7 0.6
Medication for hormone replacement therapy 1.0 1.1 4.5 0.2 0.2 0.4 1.6 0.5 -0.8 1.1 -0.8 -2.1 -2.1 -0.2 0.5 -0.9 0.3 1.2 0.7
Vitamin and mineral supplements 0.6 0.8 3.2 -0.6 -1.8 -0.4 0.2 -0.8 -1.4 -1.2 -0.5 -1.0 -0.1 -1.2 -0.6 -1.0 -0.6 -0.6 -0.5
Supplements: Zinc 0.6 0.6 1.8 -0.1 1.2 1.2 -0.3 -0.5 1.2 0.5 1.3 0.5 1.1 0.5 -0.4 0.7 -0.6 -0.4 0.1
Medication: Co-codamol 0.3 0.4 2.0 -0.7 1.4 0.0 0.5 -0.5 0.8 0.9 0.0 0.1 -0.3 -0.7 0.2 -0.6 -0.1 0.6 0.0
Medication: Metformin 0.8 1.2 3.2 -0.2 1.6 0.5 1.1 0.5 1.8 1.7 0.2 -0.1 -1.0 -0.2 1.2 0.3 -0.2 1.5 1.8
Diabetes (father) 0.6 0.8 2.5 0.6 0.8 1.4 0.8 0.5 -0.5 -0.0 -1.3 -1.6 -1.3 0.3 0.2 -0.9 1.2 0.5 0.0
Diabetes (mother) 0.4 0.5 2.4 -0.4 0.3 1.1 1.3 -0.6 0.5 0.5 -0.1 -0.4 -1.5 -0.5 0.4 -0.8 -0.0 0.9 0.1
Severe depression (siblings) 2.4 2.7 12.9 -0.7 1.3 3.6 2.0 0.8 1.5 1.7 1.2 0.9 -2.4 0.7 1.3 -0.2 -0.6 2.0 1.9
Pack years adult smoking proportion 0.9 1.4 7.4 -0.4 0.7 0.5 1.2 -0.0 2.0 1.2 0.2 0.9 -2.7 -0.5 1.6 -0.4 -0.0 1.4 1.4
Impedance of leg (right) 0.5 2.4 5.5 1.8 0.3 0.8 -2.3 2.0 -1.2 -0.6 -1.0 -1.0 2.3 1.8 -0.9 1.2 2.0 -1.4 -2.4
Leg fat-free mass (left) 0.3 1.5 8.7 0.1 0.5 -0.6 1.2 0.1 1.4 1.0 1.1 0.9 -3.0 0.1 1.3 0.5 -0.6 1.5 2.0
Trunk fat percentage 0.3 1.1 3.7 -0.7 -0.0 0.2 0.2 -0.4 1.4 -0.3 1.5 -1.5 -1.3 -0.8 1.4 0.2 -0.7 1.5 1.9
Hand grip strength (right) 0.5 1.4 5.7 1.2 2.0 -0.5 -0.2 2.4 0.2 1.6 -0.4 0.3 0.1 1.4 1.1 0.0 1.2 1.6 1.2
Townsend deprivation index at recruitment 0.4 0.6 2.2 0.3 0.8 0.8 0.8 1.2 0.8 1.5 -0.3 0.5 -0.9 0.4 0.4 0.4 0.7 0.8 0.9
Current tobacco smoking 0.4 0.6 2.9 -0.3 -1.2 -1.2 0.4 -0.5 1.7 0.6 0.9 0.2 -0.6 -0.5 0.8 0.2 -0.7 0.4 0.3
Average weekly fortified wine intake 0.8 1.0 3.3 -0.1 -0.9 1.7 -0.2 -0.3 -1.8 -1.1 -1.7 -0.9 0.8 -0.5 -0.5 -1.4 0.3 0.4 0.6
Maternal smoking around birth 0.9 1.3 3.2 -1.5 0.1 0.1 0.4 -0.9 1.7 0.9 1.8 0.7 -0.6 -1.4 1.1 -0.1 -1.7 0.9 1.6
Fed-up feelings 0.1 0.1 0.4 0.2 -0.4 -0.3 -0.5 0.2 -0.4 -0.1 0.5 -0.4 0.3 0.6 -0.4 0.2 -0.3 -0.1 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.2 0.7 -0.7 0.5 0.4 0.2 -0.1 -0.2 1.8 -0.8 -0.9 1.6 -1.1 1.3 -0.4 -0.8 -1.3
Relative age voice broke 0.9 1.4 3.9 0.6 2.0 -0.8 0.5 1.4 1.4 1.4 0.4 1.5 1.0 0.7 1.8 1.2 0.7 1.2 1.1
Taking other prescription medications 1.4 2.2 4.0 1.6 1.6 1.2 0.8 1.7 1.6 1.9 -1.2 -0.5 -0.9 1.4 1.5 0.8 2.0 2.0 1.8
Age when periods started (menarche) 0.5 1.2 5.0 1.3 -0.5 1.2 -0.8 0.8 -0.5 -1.0 -2.2 -0.2 1.8 0.5 0.5 -1.1 1.5 0.7 0.8
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 4.6 -1.0 0.8 0.5 0.4 -0.4 0.3 1.3 -0.0 0.5 -2.1 -0.9 1.0 -0.6 -0.5 1.3 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.7 -0.6 0.0 1.1 -0.6 0.3 -1.1 0.3 -0.1 0.5 -1.6 0.3 -0.7 0.5 0.3 -0.8 -0.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.8 -1.0 -1.5 0.3 -1.2 -0.9 1.0 0.1 -0.1 1.0 1.7 -1.3 0.2 -0.7 -1.0 0.1 0.7
Qualifications: CSEs or equivalent 1.1 1.5 5.9 1.3 1.1 0.4 -0.2 1.8 0.9 2.4 0.7 0.4 0.9 2.0 0.1 1.6 1.2 0.3 -0.7
Serious illness, injury or assault to yourself 0.5 0.6 1.3 0.7 0.6 -0.9 -0.5 1.0 1.1 0.1 1.0 0.9 0.5 0.5 0.8 -0.3 -0.1 1.1 0.9
High blood pressure 0.5 1.4 5.5 -1.1 -0.3 0.0 1.2 -0.4 0.1 0.1 -0.9 -0.8 -2.1 -1.6 0.8 -2.3 -0.4 1.3 1.9
Hayfever, allergic rhinitis or eczema 0.7 1.6 5.6 1.5 0.9 1.2 -0.1 2.0 -0.3 0.6 -1.2 -0.7 0.4 2.4 -0.0 2.0 2.1 -0.0 -0.6
Multivitamins +/- minerals 0.5 0.6 2.6 0.5 0.8 0.1 0.5 0.3 1.6 0.2 -0.0 0.8 -0.1 1.2 0.9 0.2 0.3 1.0 1.2
Stomach or abdominal pain in last month 0.1 0.2 0.6 0.5 -0.8 0.3 -0.2 0.0 -0.4 -0.4 0.1 -0.2 0.6 0.6 -0.6 -0.6 -0.1 0.2 0.0
Supplements: Glucosamine 0.5 0.6 1.6 -0.3 0.8 0.1 -0.3 -0.9 1.0 -0.9 -0.5 -0.6 -0.8 -0.0 1.1 -1.3 0.2 1.0 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 1.8 1.1 0.8 -0.3 1.0 0.4 -0.3 -0.3 -0.3 -0.8 0.8 1.1 -0.1 0.6 1.3 -0.3 -0.8
Medication: Atenolol 1.5 1.8 9.5 -1.5 -0.9 0.7 0.4 -1.9 -0.6 -0.9 -0.9 -0.6 -2.0 -2.3 0.1 -3.1 -0.9 0.1 0.6
Medication: Levothyroxine sodium 0.4 0.7 1.9 -1.0 -0.6 -0.1 0.1 -0.9 -0.3 -0.4 1.2 -1.1 -0.6 -1.1 -1.1 -0.7 -1.4 -0.7 -0.6
Sitting height 0.1 1.0 4.8 0.9 -0.5 2.2 -0.1 -0.1 -1.3 -0.1 -0.1 -1.1 -2.0 1.4 -0.7 0.4 0.0 -0.7 -0.2
Chronic bronchitis/emphysema (father) 0.4 0.4 1.4 -0.1 -1.0 0.8 0.0 -0.0 0.8 -0.4 0.8 0.1 -0.6 -0.5 1.0 -0.5 -0.3 1.2 0.7
High blood pressure (mother) 0.7 1.0 3.1 1.3 0.9 0.9 0.6 0.7 -0.1 1.3 -1.0 -1.4 -0.9 1.8 0.4 0.4 1.5 1.0 0.9
Body mass index (BMI) 0.2 0.8 2.6 -0.3 -0.1 -1.1 0.5 -0.6 1.0 0.0 1.6 -0.7 -1.1 -0.3 0.8 0.6 -0.7 1.1 1.5
Impedance of leg (left) 0.4 2.2 4.5 1.6 0.4 1.6 -2.0 2.0 -1.3 -0.5 -0.9 -1.1 1.9 1.7 -0.7 0.8 2.0 -1.1 -2.1
Leg predicted mass (left) 0.3 1.5 8.4 0.1 0.7 -0.6 1.2 0.1 1.4 1.0 1.1 0.9 -2.9 0.1 1.4 0.6 -0.6 1.5 2.0
Trunk fat mass 0.2 1.1 3.7 -0.2 0.2 0.0 0.4 -0.0 1.3 -0.1 1.5 -1.3 -1.9 -0.2 1.2 0.6 -0.5 1.4 1.9
Waist circumference 0.2 0.8 2.4 -0.7 -0.2 -1.4 0.2 -1.3 0.4 -0.3 1.5 -1.5 -1.0 -0.6 0.1 0.4 -1.0 0.4 0.9
Number of incorrect matches in round 0.4 0.6 2.6 -0.6 -0.2 1.4 0.5 -0.1 0.2 0.3 0.4 1.1 -1.6 -0.3 0.8 -0.1 -0.7 0.9 1.1
Past tobacco smoking 0.8 1.4 5.5 1.1 1.3 1.4 0.3 2.4 0.1 1.1 -1.1 -0.0 -1.0 1.5 1.0 0.8 1.9 0.9 0.6
Alcohol usually taken with meals 0.9 1.4 4.2 0.4 -1.1 1.1 -1.4 -0.3 -2.1 -1.7 -1.8 -0.6 1.0 0.7 -1.7 -0.8 0.7 -1.0 -0.8
Nervous feelings 0.5 1.0 5.8 0.3 0.1 -0.9 -2.4 0.7 -0.7 1.1 0.0 0.2 1.7 0.7 -0.8 0.1 0.0 -0.9 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.9 0.7 0.0 1.2 -0.3 0.4 0.0 0.3 0.8 -1.2 0.8 1.7 -1.1 1.2 0.5 -0.8 -1.5
Hearing difficulty/problems with background noise 0.9 1.4 4.1 -1.6 -1.0 0.6 1.7 -1.9 0.3 -0.1 1.5 0.3 -1.3 -1.5 -0.1 -1.2 -2.0 0.1 0.1
Hair/balding pattern: Pattern 2 0.2 0.2 1.4 0.7 0.0 -0.2 0.6 0.2 0.3 0.5 0.7 0.6 1.2 0.4 0.2 0.3 0.1 -0.0 -0.1
Had menopause 1.3 1.6 3.4 -1.3 0.3 0.5 1.6 -1.4 0.9 -0.5 0.8 0.3 -0.8 -1.8 1.7 -1.6 -0.9 1.8 1.9
Had other major operations 1.0 1.2 3.9 -1.0 0.4 2.0 0.3 -0.8 1.7 0.1 1.4 1.0 0.1 -0.7 1.1 -0.6 -1.2 1.4 1.5
Forced vital capacity (FVC) 0.1 0.4 1.6 0.4 -0.8 1.3 0.5 -0.1 -1.3 -0.3 -0.1 -0.7 -0.1 0.3 -0.4 -0.9 -0.3 0.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 3.2 -0.1 -0.6 1.1 -0.1 -0.2 -1.6 -0.4 0.0 -0.4 -1.8 0.7 -1.3 0.5 0.2 -1.1 -1.0
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.7 0.7 0.9 1.0 -0.8 0.8 0.6 1.6 -0.6 1.1 1.4 1.1 0.7 1.4 0.6 0.9 0.5
Qualifications: None of the above 0.8 1.7 8.4 -1.3 -0.3 0.0 2.9 -0.5 0.8 -0.1 2.0 -0.7 -2.3 -1.9 1.2 0.3 -1.1 0.7 0.1
Financial difficulties in last 2 years 1.4 1.8 5.6 0.7 1.4 -0.6 0.6 1.4 2.4 1.9 -0.6 0.9 -0.2 -0.0 2.2 0.3 0.9 2.4 1.6
Mouth/teeth dental problems 0.4 0.6 2.1 0.7 1.2 -0.6 -0.3 1.1 0.2 -0.0 -0.2 0.5 0.5 0.6 1.4 -0.1 0.7 1.3 0.9
Heart attack 1.4 1.7 5.6 -0.7 0.6 0.4 1.8 -0.4 2.4 1.0 0.3 1.2 -1.5 -1.0 1.5 -0.8 -1.1 1.9 2.1
Allergy 0.8 1.8 6.6 -1.8 -0.6 0.1 0.7 -1.5 0.3 -0.4 0.2 1.5 -1.0 -2.6 0.6 -2.5 -2.0 0.6 1.2
Pain all over the body in last month 0.4 0.5 1.2 0.7 -0.6 0.9 0.7 -0.4 0.3 -0.8 0.3 -0.9 -0.2 0.8 -0.8 0.8 0.3 -0.7 -1.1
Diabetes (self-reported) 0.2 0.4 1.4 0.8 0.6 0.9 0.3 0.2 0.3 0.6 -0.2 -0.7 -0.8 1.2 -0.2 0.7 0.7 -0.0 -0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.2 -0.1 0.1 -0.5 -0.0 0.4 -0.0 0.7 -0.8 -0.1 0.7 -0.1 0.7 0.2 0.1 0.6 1.1
Medication: Ramipril 0.5 0.6 2.4 -0.2 -0.5 0.8 0.2 -1.4 -0.3 -0.1 -1.5 -0.8 -0.5 -0.8 0.1 -1.2 0.2 0.7 0.8
Medication: Simvastatin 0.3 0.4 1.8 0.2 -0.4 -0.8 0.1 -0.8 -0.7 -0.5 -0.3 -1.3 -0.9 -0.2 -0.3 -1.3 -0.0 0.1 0.1
Fluid intelligence score 0.4 0.7 2.5 -0.0 -1.6 -1.4 -0.7 -0.3 -0.5 -1.1 0.0 -1.4 0.3 -0.2 -0.9 0.3 -0.2 -0.8 -1.3
Illnesses of siblings 0.7 1.0 2.7 1.3 -0.8 -1.5 -1.6 1.5 -0.3 -0.9 -1.1 0.5 0.6 0.6 0.5 1.0 1.3 0.3 0.3
Neuroticism score 0.5 1.0 3.3 1.0 0.4 1.7 -0.7 1.8 0.1 1.1 0.3 -0.1 0.5 1.5 -0.5 0.9 0.7 -0.3 -1.4
Weight 0.1 0.7 3.7 0.5 0.1 -0.5 0.2 -0.1 0.8 0.0 1.4 -0.7 -1.9 0.5 0.7 0.7 -0.3 0.9 1.4
Impedance of arm (right) 0.3 1.3 5.7 0.5 1.0 2.4 -0.8 1.2 0.1 -0.0 -2.3 -1.1 1.2 0.3 0.4 -0.7 1.5 0.4 0.2
Arm fat percentage (right) 0.2 0.7 3.1 -0.6 -0.3 0.0 0.4 -0.7 0.9 -0.6 0.9 -1.8 -0.7 -0.7 0.6 -0.0 -0.6 1.0 1.5
Trunk fat-free mass 0.1 0.7 4.9 1.2 0.4 -0.6 0.4 0.4 0.0 0.4 0.8 0.1 -2.2 1.4 0.1 1.0 0.3 0.2 0.6
Hip circumference 0.1 0.5 2.5 0.8 -0.1 -0.5 -0.2 -0.2 0.3 -0.5 0.6 -1.6 -0.8 0.9 0.5 0.4 0.2 1.0 1.2
Time employed in main current job 1.7 2.0 5.6 -2.3 -1.0 1.1 1.1 -2.0 -0.5 -1.0 -0.2 0.2 -2.2 -2.4 -0.3 -2.3 -1.2 -0.0 0.7
Alcohol intake versus 10 years previously 0.3 0.4 1.2 0.1 -0.1 1.1 0.7 -0.3 0.4 0.6 -0.9 0.9 -0.5 -0.2 0.6 0.9 0.9 0.4 0.5
Father’s age at death 0.3 0.4 1.9 0.6 -0.8 -1.4 -0.1 0.5 0.1 -0.9 0.6 0.8 -0.1 0.2 0.2 0.7 0.0 -0.4 -0.2
Worrier / anxious feelings 0.4 0.7 2.7 -1.4 -0.1 0.1 0.2 -0.3 -0.1 1.4 1.1 0.5 -0.3 -1.2 0.2 -1.0 -1.6 0.5 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.4 1.0 0.3 -0.1 0.2 0.9 0.3 1.0 0.8 -1.5 -0.3 1.3 -0.3 1.2 0.5 0.2 -0.7
Falls in the last year 0.8 1.1 4.2 -0.7 -1.8 -0.6 -0.2 -1.6 -1.1 -0.7 -0.3 -1.0 0.0 -0.7 -1.2 -2.0 -0.9 -0.6 -1.0
Hair/balding pattern: Pattern 3 1.7 2.6 8.3 1.9 0.9 0.6 -2.9 1.7 -1.6 0.0 -2.5 -0.7 0.5 2.4 -0.7 0.7 2.7 -0.4 -1.2
Number of live births 1.0 1.4 5.2 -0.0 -1.1 0.7 0.1 -1.5 -1.7 -2.3 -0.3 -2.2 -0.2 -0.3 -1.1 -1.7 -0.3 -0.7 -0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 1.1 -0.1 -0.7 0.9 -0.0 -0.3 -1.0 -0.1 0.2 -0.2 0.4 -0.3 -0.3 -1.1 -0.9 0.1 0.3
Pulse rate 0.5 0.8 4.9 1.0 0.3 1.1 -0.5 0.5 -0.3 0.5 0.1 0.9 0.6 1.5 -0.0 2.2 1.1 -0.5 -0.5
Happiness 1.0 1.2 3.8 1.4 -0.2 1.9 -1.1 1.0 -1.4 -0.0 -2.0 0.2 -0.0 1.2 -0.9 0.5 1.5 -0.7 -0.9
Noisy workplace 1.7 2.1 4.9 -1.3 1.4 -1.3 1.6 0.6 1.8 1.9 2.2 1.8 0.1 -1.0 1.4 -0.2 -1.8 1.4 1.4
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.9 2.2 0.1 1.1 -1.2 0.4 -1.0 -0.7 -2.2 0.1 1.7 2.2 -1.4 0.4 1.9 -0.8 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.9 -0.6 0.4 -1.4 -0.2 0.0 0.7 0.6 0.4 -0.3 0.0 -0.5 1.2 -0.6 -0.5 1.4 1.4
Mouth/teeth dental problems: Dentures 0.4 0.6 3.7 -0.9 0.0 1.9 0.2 -0.8 -0.0 -0.6 -0.5 -0.7 -1.3 -1.3 -0.3 -0.6 -0.4 -0.3 0.1
Asthma 1.8 3.6 13.0 3.2 0.3 -1.1 0.0 1.6 -0.7 0.1 -1.3 -2.6 1.4 3.6 -0.9 2.6 3.1 -0.7 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.6 0.7 -0.7 0.6 -0.1 -0.3 -0.3 -0.8 -0.2 -0.4 0.2 0.6 -0.1 -0.4 -0.2 0.2 -0.2
Medication: Cholesterol lowering 0.3 0.5 1.3 0.3 1.1 0.5 0.7 0.8 0.5 0.9 -0.4 -0.1 -1.0 0.4 0.8 0.2 0.6 0.8 0.8
Depression (self-reported) 1.9 2.2 8.9 0.7 1.1 1.1 1.2 1.6 1.4 3.0 1.4 -0.0 -0.8 1.4 1.4 2.3 0.4 1.5 1.9
Medication: Lansoprazole 0.5 0.5 2.2 -0.1 -0.6 -0.8 0.1 -1.5 0.7 -0.0 -0.1 0.5 0.3 -0.6 0.4 -1.4 -0.6 0.9 0.9
Prospective memory result 0.7 0.9 4.8 -1.0 -0.4 -0.2 0.9 -0.2 0.9 0.1 2.2 0.9 -1.5 -0.6 -0.0 0.5 -1.6 -0.4 0.3
Lung cancer (father) 0.7 0.9 3.1 0.4 -1.2 0.3 -1.2 -0.0 -1.8 -1.2 0.3 -0.7 1.4 0.4 -0.8 0.2 -0.1 -1.0 -1.3
Illnesses of mother 1.1 1.4 3.8 -0.3 -1.9 -1.5 -1.4 -0.3 -0.8 -1.9 -0.4 0.4 1.0 -0.5 -1.3 -0.4 -0.9 -1.8 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.4 -0.2 -0.6 0.8 0.2 -0.4 -0.6 -0.5 0.2 -0.6 -0.0 -0.4 -0.1 -0.8 -1.2 0.3 0.8
Pulse wave Arterial Stiffness index 1.2 1.4 4.7 -1.7 -1.1 0.8 0.7 -1.6 -1.1 -1.6 -0.1 -0.8 -0.2 -1.8 -0.8 -2.2 -1.1 -0.2 0.4
Impedance of arm (left) 0.3 1.2 5.2 -0.2 0.8 2.3 -0.8 0.5 0.1 -0.2 -2.0 -1.3 1.4 -0.4 0.5 -1.7 0.7 0.6 0.3
Arm fat mass (right) 0.2 0.6 2.6 -0.1 -0.1 -0.5 0.4 -0.3 0.9 -0.3 1.1 -1.3 -1.2 -0.1 0.8 0.3 -0.5 1.1 1.6
Trunk predicted mass 0.1 0.7 5.2 1.1 0.4 -0.5 0.5 0.4 0.1 0.5 0.8 0.1 -2.3 1.4 0.1 1.0 0.3 0.3 0.6
Standing height 0.1 1.0 3.8 1.7 0.8 1.2 -0.6 1.3 -0.2 0.2 -0.6 0.1 -1.9 1.8 0.4 0.2 1.1 0.4 0.3
Length of working week for main job 0.6 0.6 2.5 0.0 0.5 -0.5 0.7 0.7 1.3 1.6 1.4 0.5 -0.9 -0.0 0.8 0.7 -0.1 0.7 0.3
Exposure to tobacco smoke at home 0.5 0.5 2.1 0.7 -0.5 1.4 0.9 -0.4 -0.5 -1.2 -0.7 -0.9 -0.4 0.2 -0.3 -1.1 0.5 -0.0 -0.3
Breastfed as a baby 0.2 0.2 0.9 -0.2 0.9 0.2 -0.6 0.7 0.4 0.2 0.1 -0.1 -0.2 0.1 0.5 -0.2 -0.0 0.6 0.9
Tense / ‘highly strung’ 1.0 1.7 8.0 -0.1 1.6 0.5 -2.8 0.8 1.5 1.3 1.0 0.5 2.8 0.6 -0.2 0.3 0.2 -0.2 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.7 1.5 0.8 0.7 -0.7 0.7 1.3 1.0 -0.3 -0.3 0.7 1.7 0.7 1.2 0.9 0.9 0.1
Hair/balding pattern: Pattern 4 0.7 1.6 3.6 -1.8 -1.9 -0.5 -0.0 -1.5 -1.1 -1.9 0.8 -0.2 0.4 -1.9 -1.3 -1.2 -1.7 -1.1 -0.8
Birth weight of first child 0.9 1.7 4.2 -0.2 0.3 1.2 1.9 0.4 1.5 0.8 2.0 1.7 -1.9 0.1 1.6 1.3 -1.0 1.2 1.4
Peak expiratory flow (PEF) 0.1 0.2 1.0 -0.0 -0.4 0.6 0.2 0.1 -0.1 0.5 1.0 -0.2 0.7 0.1 -0.1 0.1 -1.0 0.1 0.4
Pulse wave reflection index 1.8 2.3 10.5 -2.0 -1.5 -0.4 0.8 -2.1 -1.4 -1.5 -0.3 -0.9 -0.2 -2.2 -1.1 -3.2 -1.8 -0.2 0.3
Ever highly irritable/argumentative for 2 days 0.6 0.8 3.9 -0.2 -0.0 -0.7 0.2 -0.0 1.7 0.4 1.7 2.0 0.7 0.3 0.3 0.3 -0.9 0.4 -0.3
Loud music exposure frequency 1.5 1.6 5.5 -1.1 2.3 2.2 0.4 0.4 1.7 1.7 2.3 0.6 0.4 0.5 0.4 1.1 -0.8 0.4 0.4
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 6.5 1.5 -0.6 -1.2 -1.4 -0.4 -1.3 -0.9 -2.6 -0.4 1.6 1.3 -1.4 -0.4 1.6 -0.8 -0.9
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.9 0.3 -0.6 -0.2 1.4 0.2 0.8 0.9 0.6 0.1 -0.4 0.4 0.1 1.1 0.0 0.1 -0.1
Blood clot in the leg (DVT) 0.5 0.7 2.7 -0.1 0.9 -1.6 -1.0 -0.4 0.6 0.7 1.1 1.1 0.7 0.1 -0.4 1.0 -0.2 -0.8 -0.7
Medication: Paracetamol 0.4 0.6 1.9 1.2 -0.4 0.4 -1.0 0.4 -0.0 -1.3 -0.6 -0.6 -0.9 1.4 -0.6 0.3 0.7 -0.2 -0.8
Headache pain in last month 0.4 0.6 1.9 -0.1 0.9 0.2 1.4 0.6 1.3 1.4 0.1 0.8 -0.5 -0.0 0.3 -0.6 -0.5 1.0 0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.4 -0.4 0.0 -0.9 -1.2 -0.5 -0.3 0.2 1.0 0.1 1.1 -0.3 -0.3 -0.1 -0.8 -0.3 -0.4
Glaucoma (self-reported) 0.3 0.4 1.1 -0.0 -0.8 -0.2 -1.1 -0.4 0.1 -0.6 0.7 -0.8 0.2 -0.2 -0.6 1.1 0.2 -0.8 -0.6
Gout (self-reported) 0.5 0.6 3.7 0.4 0.2 1.2 0.6 -0.0 0.1 -0.2 -0.2 -0.9 -1.9 0.7 0.6 -1.0 0.1 1.1 0.8
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.1 -0.0 0.7 0.7 0.7 0.7 0.5 0.5 0.1 -0.3 -1.1 -0.3 0.2 0.5 -0.0 0.5 0.5
Medication: Amlodipine 0.4 0.5 2.1 -0.6 -1.0 0.6 1.1 -0.5 0.5 0.1 -0.3 -0.2 -1.5 -0.6 0.5 -0.5 -0.6 0.5 1.2
Medication: Ventolin 100micrograms inhaler 2.3 2.9 9.4 2.8 0.6 -0.4 -0.8 2.6 0.1 1.2 -2.4 -1.4 1.0 2.9 0.5 1.6 3.1 0.7 0.1
Birth weight 0.3 0.6 2.2 0.2 -0.2 -1.2 0.1 -0.4 -0.4 -0.1 -0.6 -0.5 -0.3 -0.4 1.3 -1.4 0.0 1.5 1.1
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.9 -0.7 1.6 1.0 1.2 0.4 0.6 1.0 1.0 0.1 -1.5 -0.5 1.4 -1.0 -0.3 1.7 1.6
High blood pressure (siblings) 0.6 0.8 2.9 -1.3 0.9 0.5 0.5 -1.7 0.5 1.4 1.1 -0.1 0.6 -1.1 -0.5 -0.4 -1.2 -0.4 -0.3
Forced vital capacity (FVC), Best measure 0.2 0.9 2.5 0.2 -1.5 1.4 0.6 -0.4 -1.5 -1.3 -0.5 -1.6 -0.7 0.0 -0.8 -1.1 -0.8 -0.2 0.4
Body fat percentage 0.2 0.9 2.7 -0.5 -0.3 -0.1 0.1 -0.3 1.1 -0.5 1.6 -1.6 -1.2 -0.5 1.0 0.6 -0.5 1.1 1.5
Leg fat percentage (right) 0.2 0.7 3.1 0.4 -0.2 -0.9 -0.4 0.4 0.4 -0.6 1.6 -1.8 -0.4 0.6 -0.0 1.6 0.2 -0.1 -0.1
Arm fat-free mass (right) 0.2 0.9 5.5 0.8 0.5 -1.0 0.2 0.5 0.6 0.7 1.5 0.5 -2.4 0.9 0.7 1.0 -0.1 0.7 0.8
Exposure to tobacco smoke outside home 0.4 0.5 1.6 0.3 -0.6 0.8 0.1 -0.8 -0.8 -0.3 -0.3 -1.1 0.7 0.9 -1.3 -0.0 0.2 -0.9 -1.0
Comparative body size at age 10 0.1 0.4 2.9 0.4 0.2 -1.7 -1.3 0.2 0.7 0.7 0.3 0.3 0.3 0.0 0.4 0.3 -0.3 0.5 0.1
Number of full brothers 0.5 0.6 1.9 -0.1 0.7 -0.9 0.4 0.0 0.8 1.1 1.2 0.7 1.4 -0.1 -0.2 0.9 -0.1 -0.5 -0.9
Worry too long after embarrassment 0.5 0.9 3.7 -1.6 1.3 0.2 0.8 0.3 0.8 1.9 0.7 0.3 -0.1 -1.1 0.1 -1.0 -1.2 0.5 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 5.8 1.4 1.5 -0.2 -1.5 1.1 1.0 0.7 -1.0 -0.3 2.4 1.8 0.1 1.1 1.9 -0.0 -0.2
Wheeze or whistling in the chest in last year 0.5 0.9 5.6 2.4 -0.8 0.0 -0.3 1.0 0.0 -0.1 -0.3 -0.8 -0.2 1.8 0.3 0.9 1.3 0.4 -0.2
Number of children fathered 0.7 0.8 1.7 -0.7 -1.2 -1.2 -0.7 -1.1 -0.5 -0.8 0.7 -1.2 1.3 -0.6 -0.5 -1.0 -1.1 -0.2 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.9 -0.8 -0.5 -1.0 -1.7 -1.0 -0.6 -0.6 -0.3 -1.0 0.8 -1.6 0.9 -1.6 -1.0 0.9 1.0
Age at first live birth 1.1 1.9 5.1 -2.3 -0.1 0.5 -0.2 -1.8 -0.4 -0.4 0.8 1.8 2.2 -2.0 -0.4 -1.9 -2.1 -0.1 0.5
Pulse wave peak to peak time 1.2 1.4 4.8 1.8 1.1 -0.8 -0.6 1.7 1.0 1.5 0.2 0.7 0.2 2.0 0.7 2.2 1.2 0.1 -0.6
Health satisfaction 0.3 0.4 3.3 -0.4 -0.5 1.8 -0.8 -0.1 -0.2 0.6 -0.4 0.0 0.3 -0.8 0.1 -0.3 -0.6 -0.3 0.3
Shortness of breath walking on level ground 0.5 0.6 3.7 -0.2 0.4 -1.9 -1.3 0.4 0.7 0.8 0.8 0.5 0.5 -0.7 0.8 0.1 -0.2 0.9 0.6
Qualifications: College or University degree 0.4 1.3 5.4 1.2 1.1 0.5 -1.6 1.0 -0.7 0.2 -0.7 1.0 1.6 2.3 -0.5 1.3 1.3 -0.4 -0.4
Eye problems/disorders: None of the above 0.5 0.5 2.1 0.5 -0.1 -0.2 1.4 0.5 0.7 1.0 0.7 0.1 -0.8 0.8 1.1 1.0 0.2 0.3 0.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.8 0.9 1.0 -0.3 1.2 0.3 0.0 1.3 -0.7 0.2 -0.2 1.2 0.4 0.1 1.3 0.3 0.0
Emphysema/chronic bronchitis 0.3 0.3 1.0 -0.1 -1.0 -0.6 -1.0 -0.5 0.1 0.5 0.8 0.7 -0.7 -0.4 0.3 0.7 0.1 -0.1 -0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 3.1 -0.2 0.3 -1.1 -0.9 -0.1 -0.4 0.1 -0.5 1.2 1.8 -0.5 0.4 -0.4 0.4 -0.2 0.1
Neck or shoulder pain in last month 0.2 0.2 1.2 0.2 -0.3 0.3 -0.5 0.4 -0.4 1.1 -0.1 -0.5 0.7 0.0 0.4 0.4 0.2 0.7 0.2
Medication: Blood pressure 0.7 1.3 4.0 -0.8 -0.8 0.9 1.5 -0.7 0.7 -0.4 -0.8 0.3 -1.4 -1.5 1.3 -1.5 -0.5 1.5 2.0
Angina (self-reported) 0.3 0.4 1.3 -0.4 -0.2 -0.9 0.1 -0.7 1.1 0.4 0.2 0.5 -1.0 -1.1 0.8 -0.2 -0.2 0.7 0.6
Migraine (self-reported) 0.3 0.3 1.1 -0.1 0.5 -1.0 0.2 -0.2 0.6 0.6 0.8 1.0 0.3 -0.5 0.1 0.7 -0.6 -0.0 -0.0
Medication: Ibuprofen 0.4 0.5 2.0 0.5 -1.1 0.7 -0.1 -1.1 -0.3 -1.4 -0.2 -0.7 0.7 0.3 -0.2 -1.0 -0.6 0.3 -0.1
Medication: Allopurinol 0.3 0.4 2.2 0.4 -0.7 -0.3 0.3 -0.2 -0.0 -1.5 0.6 -1.1 -1.1 1.0 -0.2 -0.1 0.0 0.2 -0.1
Medication: Omeprazole 0.5 0.6 1.7 1.2 0.3 0.1 0.8 0.9 1.3 0.7 0.0 -0.7 -0.5 0.7 0.8 0.9 0.6 1.0 0.6
Medication: Seretide 50 evohaler 1.6 1.8 6.8 2.2 0.5 -0.1 -0.9 1.4 1.1 0.9 -0.1 1.6 2.0 2.0 -0.1 2.6 1.4 -0.3 -0.4
Mean time to correctly identify matches 0.4 0.9 2.6 -1.0 -0.2 -0.9 0.1 -1.2 -0.5 -1.4 -0.3 -1.2 0.5 -0.8 -1.2 -0.5 -0.4 -1.0 -1.6
Heart disease (mother) 0.1 0.2 0.6 0.8 -0.3 0.1 -0.7 0.0 0.0 -0.0 0.0 0.6 0.4 -0.3 0.3 -0.3 0.5 0.5 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 10.7 -0.5 0.0 -3.3 -0.4 -1.5 0.5 -0.4 1.1 1.1 2.0 -1.2 0.1 0.2 -0.5 0.3 -0.1
Whole body fat mass 0.2 0.8 2.8 0.0 -0.0 -0.1 0.4 0.1 1.1 -0.1 1.5 -1.1 -1.7 0.0 1.1 0.8 -0.3 1.2 1.6
Leg fat mass (right) 0.2 0.8 2.6 0.6 0.1 -0.5 0.1 0.7 1.0 0.0 1.6 -0.7 -1.6 0.5 0.9 1.6 0.1 0.9 1.0
Arm predicted mass (right) 0.2 1.2 7.6 0.7 0.5 -1.1 0.6 0.6 0.8 0.8 1.7 0.6 -2.8 0.8 0.9 1.0 -0.3 1.0 1.2
Pulse rate, automated reading 0.1 0.4 1.3 0.1 1.2 1.0 0.4 0.6 0.2 0.7 -0.2 -1.0 0.1 0.5 -0.2 1.0 0.8 -0.0 -0.1
Alcohol intake frequency. 0.4 0.9 3.1 1.2 0.6 1.0 -0.3 1.4 1.5 -0.0 -0.9 0.3 -0.5 0.7 0.8 1.2 1.8 0.5 -0.0
Comparative height size at age 10 0.1 0.6 3.2 0.9 1.0 -0.3 -0.1 0.8 -1.2 0.1 -0.8 -0.6 -1.8 1.0 -0.1 -0.3 0.6 -0.0 -0.5
Number of full sisters 0.9 1.1 4.6 -1.1 0.6 -0.7 0.3 -0.1 1.9 0.6 2.1 1.5 -0.6 -1.1 0.6 1.2 -1.1 -0.0 0.2
Suffer from ‘nerves’ 1.4 2.2 9.5 1.4 0.5 0.6 -3.0 1.5 -0.9 1.0 -0.6 0.8 3.1 2.1 -0.3 1.1 1.6 -0.2 -1.1
Overall health rating 0.6 1.4 3.5 1.1 0.6 1.4 1.0 1.2 1.0 1.9 -0.4 -0.3 -1.7 0.7 1.2 1.4 0.9 1.2 1.3
Chest pain or discomfort 0.3 0.4 2.1 1.1 -0.3 0.3 -0.2 0.6 0.5 -0.0 -0.8 -0.6 1.4 0.6 0.1 0.0 1.1 0.4 -0.3
Had major operations 0.5 0.5 1.9 -0.6 -0.1 1.3 1.4 0.1 0.2 0.1 0.5 0.7 -1.3 -0.5 -0.3 -0.2 -0.7 0.6 0.9
Age at last live birth 1.0 1.4 5.6 -2.1 0.1 0.3 0.6 -2.4 -0.2 -0.8 0.9 0.8 1.1 -1.9 -0.5 -1.5 -1.6 -0.1 0.1
Family relationship satisfaction 1.1 1.4 5.3 1.3 0.2 1.3 -2.3 1.1 -0.4 0.2 -0.8 0.1 0.9 1.8 -1.1 1.1 1.1 -1.1 -1.8
Leg pain on walking 0.8 1.1 3.6 -0.7 1.8 0.7 1.9 0.3 1.3 1.2 0.4 -1.4 -1.1 -0.5 0.9 -0.1 -0.1 1.0 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.9 -0.3 1.0 -1.2 -0.3 0.5 0.7 1.4 -0.5 0.9 0.5 -0.6 0.6 -1.0 -0.3 0.5 0.6
Commuting to job workplace: Car/motor vehicle 1.3 1.5 5.6 -1.3 -1.5 -1.0 0.1 -2.3 -1.3 -1.2 -0.1 -0.7 0.7 -1.3 -0.7 -2.4 -1.4 -0.3 -0.5
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 5.0 -1.0 -2.1 0.8 -0.2 -2.2 -1.7 -1.9 0.6 -1.5 0.1 -0.6 -2.2 -0.3 -1.2 -2.2 -1.7
Medication: Aspirin 0.9 1.2 4.1 -0.0 1.2 0.9 1.8 1.3 1.0 1.2 -0.3 -0.3 -2.0 -0.1 1.1 0.3 0.4 1.2 1.6
Supplements: Vitamin C 0.9 1.1 7.6 0.4 1.3 0.6 0.0 0.7 0.8 1.2 1.5 0.2 0.5 1.2 0.1 2.8 0.6 -0.1 0.1
Knee pain experienced in last month 0.3 0.5 3.7 -0.2 0.2 1.0 0.3 0.0 0.2 -0.0 0.2 -1.9 -1.0 -0.3 0.5 -0.6 -0.1 0.6 0.9
Hypertension (Self-reported) 0.5 1.3 4.8 -1.0 -0.1 -0.1 1.1 -0.4 0.4 0.4 -0.9 -0.6 -1.9 -1.5 0.8 -2.2 -0.3 1.3 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.3 -0.6 -0.3 1.5 0.1 -0.7 1.4 0.8 0.9 0.2 -0.2 -0.7 0.8 -0.3 -0.8 0.9 0.8
Illnesses of father: Heart disease 1.8 2.5 6.2 -1.8 0.2 2.5 1.2 -1.4 1.9 0.6 0.9 1.5 -2.2 -1.9 0.8 -2.0 -2.1 0.8 1.5
Illnesses of siblings: Diabetes 0.5 0.6 4.2 0.3 0.9 2.0 0.9 -0.0 -0.3 0.2 -0.8 -0.1 -1.3 0.1 0.3 -0.8 0.8 0.5 0.2
Smoking status: Previous 1.3 1.9 5.2 -0.8 -1.2 -1.2 -1.1 -2.3 -1.0 -2.0 0.7 -1.0 1.9 -0.9 -1.8 -0.6 -1.5 -1.5 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.9 1.4 -0.4 0.9 -0.4 0.8 -0.9 -1.2 -0.3 -0.3 -1.0 1.4 -0.7 0.4 0.6 -0.9 -0.7
Whole body fat-free mass 0.2 0.9 7.2 0.6 0.5 -0.6 0.8 0.2 0.6 0.6 1.1 0.5 -2.7 0.8 0.6 0.8 -0.1 0.8 1.1
Leg fat-free mass (right) 0.3 1.7 9.9 -0.2 0.5 -0.3 1.4 -0.2 1.4 1.0 1.2 0.9 -3.1 -0.2 1.4 0.2 -0.8 1.6 2.2
Arm fat percentage (left) 0.2 0.8 3.1 -0.8 -0.3 -0.2 0.3 -0.8 1.0 -0.6 1.1 -1.8 -0.7 -0.9 0.7 -0.2 -0.8 1.1 1.6
Average weekly red wine intake 0.2 0.3 1.7 -0.1 0.2 -0.4 -0.4 0.3 0.6 0.1 0.3 1.1 0.3 0.5 0.5 0.2 -0.1 0.6 1.3
Handedness (chirality/laterality): Left-handed 1.7 2.1 5.1 -0.8 -1.7 -1.6 -1.0 -1.5 -1.7 -2.3 -0.8 -1.5 1.4 -1.0 -1.7 -1.3 -0.4 -1.6 -1.6
Mood swings 0.1 0.2 1.5 -0.0 0.2 0.8 -0.2 0.5 0.7 0.1 1.2 0.2 -0.2 0.3 0.2 0.3 -0.5 0.4 -0.1
Loneliness, isolation 0.3 0.4 2.6 -0.2 0.0 1.6 1.1 -0.3 0.9 -0.0 0.3 0.6 -0.9 -0.5 0.2 -0.1 -0.5 0.2 0.1
Long-standing illness, disability or infirmity 0.3 0.4 1.4 1.2 -0.2 1.0 0.6 0.5 0.5 0.1 -0.1 -0.1 -0.3 1.0 0.4 0.8 0.5 0.9 0.9
Ever had bowel cancer screening 0.9 1.0 4.2 0.1 -1.1 0.7 -1.3 -0.9 -1.4 -2.0 -0.9 -1.3 0.8 -0.2 -1.1 -0.6 -0.2 -0.8 -0.4
Diabetes diagnosed by doctor 0.3 0.5 1.6 0.4 0.7 1.3 0.6 0.1 0.7 0.9 -0.0 -1.0 -1.0 0.7 0.2 0.4 0.5 0.5 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.3 0.3 -0.7 -0.3 0.3 -1.4 -0.4 -1.2 -0.8 -1.5 -0.8 0.1 -0.9 -0.1 0.2 -1.1 -0.9
Friendships satisfaction 0.2 0.2 0.5 -0.2 -0.7 0.3 0.7 0.1 -0.2 0.5 -0.3 -0.6 -0.7 -0.2 -0.4 -0.6 -0.1 -0.2 -0.4
Qualifications: nursing, teaching 0.2 0.3 1.3 0.2 -0.4 -0.9 -0.1 -0.5 -0.3 -0.6 -0.0 -0.3 1.1 0.9 -0.3 -0.4 -0.4 0.4 0.3
Commuting to job workplace: Walk 1.7 1.9 6.4 1.4 1.9 0.6 -0.2 2.5 0.6 1.2 -0.8 1.4 0.3 1.5 1.4 1.7 1.9 1.3 0.9
Eye problems/disorders: Cataract 0.6 0.7 1.9 -0.9 -0.4 -0.6 -1.3 -1.4 -0.4 -1.0 0.2 0.1 0.9 -1.0 -1.1 -0.8 -1.0 -0.7 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 3.1 0.0 -1.8 -0.3 0.9 -0.6 0.1 -0.3 0.2 0.2 -0.5 -0.2 -0.4 -0.8 -0.6 -0.4 -0.4
Medication for cholesterol 0.9 1.4 8.1 -0.1 0.4 0.2 0.1 0.5 1.3 -0.2 0.8 2.4 2.9 0.5 0.3 2.1 -0.2 -0.7 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.8 -1.0 -0.4 0.5 0.9 -1.5 0.7 0.1 0.7 1.4 -1.2 -1.7 0.8 -1.5 -1.2 1.0 0.8
Back pain experienced in last month 0.6 0.9 3.0 0.9 -0.7 -0.8 -1.2 0.5 -1.3 0.5 0.5 -1.1 0.7 1.1 -1.3 1.1 0.2 -0.8 -1.7
Mineral and other dietary supplements 1.3 1.7 8.7 -0.5 -2.9 -0.2 -0.3 -0.9 -2.2 -0.5 0.4 -0.8 1.8 -0.8 -1.5 0.4 -1.0 -1.7 -1.3
Breast cancer (self-reported) 0.4 0.5 1.6 -0.2 -0.1 1.1 -0.4 -0.8 0.1 -1.1 1.2 0.8 0.5 0.0 -0.1 -0.9 -0.7 0.4 0.4
Asthma (self-reported) 2.1 4.2 16.0 3.4 0.7 -0.7 -0.2 2.0 -0.6 0.6 -1.6 -2.3 1.3 4.0 -0.6 3.1 3.6 -0.6 -1.2
Osteoporosis (self-reported) 0.8 1.0 2.8 1.5 0.8 -1.0 -0.1 1.1 0.9 0.4 -0.5 -0.5 1.7 1.3 0.8 1.6 1.4 0.9 0.3
Osteoarthritis (self-reported) 0.8 1.0 3.4 -1.3 1.0 -0.3 1.0 -0.6 1.2 0.6 1.8 -0.5 -1.9 -0.8 0.5 -0.0 -1.3 0.8 0.6
Medication: Aspirin 0.9 1.2 4.8 -0.3 0.9 1.2 2.0 0.7 0.9 0.7 -0.1 -0.7 -2.2 -0.4 1.2 0.0 -0.0 1.3 1.5
Medication: Gliclazide 0.7 0.8 4.3 -0.1 0.6 -1.0 -2.1 -0.2 -0.7 0.4 -0.7 -0.9 0.4 -0.4 -1.1 -0.4 0.1 -1.2 -1.4
Illnesses of father: None of the above (group 1) 1.0 1.3 3.3 1.3 0.6 -1.6 -0.1 1.3 -1.2 -0.7 -0.0 -0.1 1.8 1.6 -0.7 1.6 1.2 -0.6 -1.2
Smoking status: Current 0.5 0.7 2.9 -0.4 -1.4 -1.0 0.8 -0.6 1.7 0.4 1.0 0.4 -1.0 -0.6 1.0 0.2 -0.9 0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 5.4 -0.5 -1.4 0.2 -0.6 -0.7 -2.1 -2.3 -0.8 -1.4 0.5 -0.3 -1.3 -1.3 -1.0 -0.8 -0.2
Whole body water mass 0.2 0.9 7.3 0.6 0.5 -0.6 0.8 0.3 0.6 0.7 1.1 0.4 -2.7 0.8 0.6 0.7 -0.2 0.8 1.2
Leg predicted mass (right) 0.3 1.7 10.0 -0.2 0.6 -0.2 1.3 -0.1 1.3 1.1 1.2 0.9 -3.2 -0.1 1.4 0.2 -0.8 1.6 2.2
Arm fat mass (left) 0.2 0.6 2.0 -0.4 -0.1 -0.4 0.3 -0.7 0.7 -0.3 1.4 -1.3 -1.0 -0.3 0.6 0.1 -0.7 1.0 1.4
Number of self-reported non-cancer illnesses 0.9 1.5 5.1 0.7 0.4 -0.1 1.4 0.6 0.9 1.3 -0.5 -1.3 -1.9 0.6 1.6 1.0 0.6 2.0 2.3
Average weekly champagne plus white wine intake 1.9 2.6 9.6 0.8 -0.5 0.1 -1.0 -0.6 -2.5 -1.3 -0.5 -1.8 0.6 1.3 -3.1 0.0 0.5 -2.5 -3.0
Miserableness 0.6 1.1 3.3 0.5 -1.3 0.5 -1.4 -0.2 -1.2 -0.9 0.6 -1.2 0.4 1.1 -1.8 0.0 -0.7 -1.3 -1.6
Guilty feelings 0.2 0.3 0.8 -0.2 0.2 0.9 -0.7 0.5 0.6 0.8 0.4 -0.3 -0.1 -0.2 0.3 0.1 -0.4 0.7 0.7
Wears glasses or contact lenses 0.5 0.6 2.9 0.5 0.3 -0.8 -0.2 -0.3 0.3 -0.3 -0.7 -1.7 0.5 0.0 1.1 -0.1 0.5 1.1 1.3
Ever taken oral contraceptive pill 3.1 3.5 11.5 2.1 -0.0 2.0 -2.1 2.1 -1.8 -0.2 -3.4 -0.8 0.4 3.1 -1.3 1.1 2.8 -1.1 -0.7
Hearing aid user 0.5 0.5 1.5 0.5 -1.2 0.7 1.1 0.5 -0.8 -0.9 0.2 -0.7 -1.1 -0.0 -0.6 -0.9 -0.5 -0.3 -0.5
Mother’s age at death 1.2 1.5 4.2 1.1 1.5 2.1 0.7 1.3 1.1 1.0 -1.2 0.6 -1.4 0.8 1.4 -0.3 1.4 1.6 1.0
Financial situation satisfaction 1.4 1.7 3.9 1.6 1.8 -0.6 -0.2 1.9 1.2 1.6 -1.0 0.8 0.8 1.0 1.4 1.8 2.0 0.9 0.2
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.5 0.1 1.9 -0.3 1.2 0.3 1.8 0.7 -0.9 1.2 -0.7 0.2 1.1 -0.9 0.5 1.7 1.4
Commuting to job workplace: Public transport 1.0 1.2 3.7 1.5 1.3 1.7 -0.3 1.9 -0.8 0.6 -1.2 -0.3 -0.6 1.2 -0.3 0.8 1.9 -0.5 -0.2
Eye problems/disorders: Glaucoma 0.3 0.3 1.7 0.2 -0.7 -0.3 -0.8 -0.1 0.1 -0.8 0.1 -1.3 0.1 -0.2 0.0 0.8 0.6 -0.4 -0.6
Medication: Blood pressure 0.8 1.5 7.3 -0.4 -0.8 -1.1 -0.4 -1.2 -1.5 -0.7 -1.0 -2.7 -1.4 -1.0 -1.0 -2.2 0.1 -0.3 -0.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 3.5 0.4 0.3 -0.0 0.3 0.6 0.4 0.9 1.0 -0.7 0.1 0.8 0.4 1.9 0.7 0.5 -0.1
Supplements: Fish oil (including cod liver oil) 2.1 2.7 9.7 0.1 2.3 1.1 1.1 1.0 2.4 1.2 -0.5 1.9 -3.1 0.0 2.1 -0.7 0.5 2.1 2.0
High cholesterol (Self-reported) 0.2 0.4 1.1 1.0 0.9 0.2 0.0 1.0 -0.2 0.2 -0.1 -0.7 -1.1 1.1 0.3 0.2 1.0 0.6 0.2
Medication: Bendroflumethiazide 0.7 1.0 4.2 -0.2 0.1 0.2 1.6 0.3 -0.3 -0.8 -1.2 -1.9 -2.0 -0.9 0.3 -1.4 0.5 0.6 0.9
Medication: Paracetamol 0.7 1.0 5.9 0.5 -1.6 0.4 -0.9 -0.7 -0.0 -2.4 0.1 -1.1 -0.6 0.8 -1.4 -0.1 -0.2 -0.7 -1.0
Medication: Lisinopril 0.8 1.0 5.3 0.0 -1.4 -0.1 0.5 -1.3 -0.1 -1.5 -0.4 -0.5 -0.6 -0.6 0.6 -2.3 -0.8 1.0 1.4
Medication: Atorvastatin 0.4 0.5 1.8 -0.2 1.4 0.5 -0.7 0.4 -0.3 1.2 -0.8 0.8 -1.2 -0.1 -0.2 -0.6 0.5 -0.1 0.1
Illnesses of father: High blood pressure 1.0 1.2 3.9 -1.2 -1.8 0.2 0.6 -1.8 -1.0 0.2 0.1 -0.5 -0.8 -1.6 -0.6 -2.0 -1.4 -0.5 -0.3
Alcohol drinker status: Never 1.1 1.3 3.3 0.8 0.6 -0.6 0.3 1.7 0.8 0.8 -1.6 0.2 -1.0 0.2 1.7 -0.4 1.5 1.8 1.6
Ever smoked 0.6 1.0 3.4 -0.7 -1.4 -1.8 0.1 -1.6 -0.1 -1.0 1.0 0.5 0.7 -1.1 -0.6 -0.8 -1.5 -0.5 -0.6
Basal metabolic rate 0.2 0.9 6.2 0.7 0.5 -0.5 0.6 0.3 0.7 0.7 1.2 0.3 -2.5 0.9 0.7 0.9 -0.1 0.8 1.2
Leg fat percentage (left) 0.2 0.6 3.5 0.0 -0.1 -0.5 -0.1 0.1 0.6 -0.5 1.9 -1.6 -0.8 0.2 0.3 1.2 -0.1 0.4 0.4
Arm fat-free mass (left) 0.2 0.8 5.0 0.7 0.5 -1.2 0.3 0.2 0.5 0.7 1.4 0.3 -2.2 0.9 0.5 1.1 -0.1 0.5 0.7
Number of operations (self-reported) 2.4 3.6 9.8 -1.1 1.5 1.2 3.1 -0.2 2.7 1.7 1.4 1.3 -1.9 -1.1 2.4 0.4 -1.1 2.7 3.1
Average weekly beer plus cider intake 1.0 1.4 8.1 0.9 0.0 -2.8 1.1 1.2 0.9 0.5 1.1 0.8 1.0 0.6 1.4 1.3 0.2 1.1 1.4
Irritability 1.3 2.2 8.9 1.5 0.2 1.5 -1.1 2.4 0.1 0.3 0.9 -0.1 -0.1 2.9 -0.8 3.0 1.1 -0.9 -1.7
Risk taking 1.2 1.8 6.5 1.5 1.6 -0.9 0.2 1.1 1.2 1.9 0.5 0.5 0.2 2.1 1.1 2.6 1.6 0.8 0.6
Ever had prostate specific antigen (PSA) test 0.4 0.4 2.7 0.5 -1.0 -0.2 0.5 -0.0 0.8 -1.6 0.6 -0.4 0.1 0.8 -0.1 0.0 -0.3 0.4 0.8
Fractured/broken bones in last 5 years 0.9 1.1 2.9 0.7 1.7 0.7 1.3 1.0 1.7 1.6 1.1 0.6 -0.3 0.9 1.0 1.5 0.6 0.4 0.5
Age started oral contraceptive pill 0.5 0.6 1.8 -0.5 -1.3 -1.2 0.3 -0.6 -0.6 -1.4 0.1 -0.3 -0.0 -1.1 0.3 -1.0 -0.8 0.5 -0.1
Diastolic blood pressure, automated reading 0.2 0.6 1.9 -0.5 -0.7 -1.1 0.4 -0.8 -0.0 -0.9 0.7 -0.2 0.6 -0.5 0.4 -1.0 -0.9 1.0 1.4
Ever depressed for a whole week 0.6 0.8 2.8 0.2 0.0 0.5 -0.8 0.3 0.9 1.7 -1.2 1.5 0.1 -0.3 1.4 0.2 0.4 1.1 0.6
Unable to work because of sickness or disability 0.2 0.3 1.4 0.5 -0.1 1.1 1.2 0.4 0.4 0.7 0.1 0.2 -0.3 0.5 -0.2 0.9 0.4 0.1 0.1
Commuting to job workplace: Cycle 1.1 1.4 3.9 -1.2 2.0 -1.2 0.2 -0.2 1.5 1.2 1.6 0.9 0.6 -0.9 1.2 -1.0 -1.4 1.4 0.9
Myopia 0.8 1.1 3.5 -1.1 -0.8 1.0 1.1 -1.3 0.8 -0.8 0.1 1.0 -0.6 -1.3 1.0 -1.2 -0.9 1.0 1.9
Vascular/heart problems diagnosed by doctor 0.9 2.3 8.4 1.3 0.2 -0.4 -1.6 0.6 -1.0 -0.4 0.5 0.1 2.9 2.1 -1.4 2.4 0.7 -1.9 -2.5
Cholesterol lowering medication 0.9 1.3 4.4 -1.0 0.6 -0.9 1.6 -1.6 -0.2 0.8 0.7 -1.4 -2.1 -1.1 0.1 -1.9 -0.8 0.7 0.7
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.6 1.2 -0.5 0.1 0.1 0.6 0.5 -0.1 -0.2 -1.2 -0.3 0.8 -0.0 0.6 0.4 0.3 0.0
Pain experienced in last month 0.9 1.5 3.6 -1.2 -1.6 -0.2 0.9 -1.8 0.1 -1.4 0.9 0.9 -1.5 -1.5 0.7 -1.5 -1.9 0.3 1.2
Supplements: Calcium 1.9 2.1 5.2 0.7 2.3 1.6 1.1 0.9 1.8 1.6 -0.7 -0.4 -2.1 0.4 1.8 -0.2 1.0 2.2 1.9
Basal cell carcinoma (self-reported) 1.1 1.3 4.2 0.5 -1.6 -1.1 -1.0 -0.8 -1.8 -2.0 -1.3 -1.4 0.6 -0.2 -0.8 -1.4 -0.0 -0.9 -0.8
Heart attack/myocardial infarction (self-reported) 1.2 1.6 5.4 -0.6 0.6 0.1 1.6 -0.4 2.3 1.0 -0.2 1.2 -1.4 -1.0 1.6 -0.9 -0.8 1.8 2.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 2.7 0.0 1.0 -1.6 -0.9 -0.4 0.6 0.9 0.6 1.3 0.7 0.0 -0.1 0.7 -0.1 -0.4 -0.4
Heart disease (siblings) 0.8 0.9 3.6 -1.7 0.0 -0.8 1.9 -1.3 0.8 0.5 0.6 -0.8 -0.8 -1.4 -0.4 -0.5 -1.1 -0.6 -0.2
Alcohol drinker status: Previous 0.7 0.8 3.1 0.2 -1.0 -0.4 -1.6 -1.3 0.4 -1.1 1.1 0.3 1.8 0.1 -0.5 0.5 -0.9 -0.8 -0.4
Pack years of smoking 1.1 1.6 7.4 -0.6 0.9 0.6 1.1 0.1 2.1 1.1 0.2 0.9 -2.7 -0.7 1.7 -0.4 -0.1 1.5 1.6
Impedance of whole body 0.3 1.3 5.0 0.7 0.7 2.2 -1.6 1.3 -0.5 -0.3 -1.7 -1.3 1.6 0.6 0.1 -0.4 1.5 -0.2 -0.8
Leg fat mass (left) 0.2 0.9 3.1 0.3 0.2 -0.4 0.2 0.5 1.1 0.1 1.8 -0.6 -1.7 0.4 1.0 1.5 -0.1 1.0 1.1
Arm predicted mass (left) 0.2 0.9 5.4 0.8 0.4 -1.1 0.5 0.3 0.6 0.8 1.6 0.4 -2.3 0.9 0.5 1.3 -0.2 0.5 0.7