TWAS hub - LRRC56

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1900	0.0360	3.7e-12	0.122	0.123	0.161	0.160	0.171	1.2e-14	8.5e-15	4.3e-19	5.9e-19	2.5e-20
2	GTEx	Brain Cerebellum	0.2810	0.0750	1.8e-04	0.215	NA	0.114	NA	0.171	5.6e-07	NA	3.0e-04	NA	9.0e-06
3	GTEx	Cells Transformed fibroblasts	0.1990	0.0490	6.2e-07	0.118	NA	0.104	NA	0.131	4.1e-09	NA	3.4e-08	NA	5.0e-10
4	GTEx	Esophagus Gastroesophageal Junction	0.2820	0.0920	2.3e-03	-0.008	NA	0.025	NA	-0.008	9.6e-01	NA	4.3e-02	NA	9.0e-01
5	GTEx	Esophagus Mucosa	0.1700	0.0550	1.2e-03	0.101	NA	0.045	NA	0.083	2.9e-07	NA	5.8e-04	NA	3.5e-06
6	GTEx	Heart Atrial Appendage	0.2110	0.0780	4.2e-03	-0.002	NA	-0.006	NA	-0.005	4.3e-01	NA	9.3e-01	NA	6.0e-01
7	GTEx	Nerve Tibial	0.2571	0.0579	2.7e-08	0.191	NA	0.144	NA	0.169	1.6e-13	NA	2.2e-10	NA	4.7e-12
8	GTEx	Skin Not Sun Exposed Suprapubic	0.1950	0.0600	1.9e-04	0.120	NA	0.111	NA	0.121	4.2e-07	NA	1.1e-06	NA	3.9e-07
9	GTEx	Skin Sun Exposed Lower leg	0.1270	0.0410	7.1e-04	0.052	NA	0.095	NA	0.106	3.9e-05	NA	2.7e-08	NA	4.1e-09
10	GTEx	Testis	0.1780	0.0610	1.3e-03	0.144	NA	0.134	NA	0.162	6.0e-07	NA	1.5e-06	NA	1.2e-07
11	GTEx	Thyroid	0.1210	0.0410	4.6e-04	0.060	NA	0.015	NA	0.036	2.4e-05	NA	2.3e-02	NA	9.0e-04
12	METSIM	Adipose	0.0513	0.0203	1.7e-03	0.028	0.012	0.040	0.032	0.034	3.6e-05	5.6e-03	9.1e-07	1.2e-05	6.9e-06
13	ROSMAP	Brain Pre-frontal Cortex	0.2650	0.0441	3.6e-12	0.069	0.138	0.130	0.162	0.132	3.2e-09	2.2e-17	2.4e-16	2.9e-20	1.2e-16
14	YFS	Blood	0.1483	0.0268	0.0e+00	0.089	0.127	0.123	0.128	0.124	9.7e-28	2.6e-39	3.3e-38	8.3e-40	2.7e-38
15	TCGA	Brain Lower Grade Glioma	0.0477	0.0224	9.4e-04	0.010	0.024	0.011	NA	0.012	2.1e-02	7.8e-04	1.8e-02	NA	1.5e-02
16	TCGA	Lung Adenocarcinoma	0.0298	0.0158	9.3e-03	0.006	0.013	0.007	NA	0.010	6.6e-02	1.0e-02	4.4e-02	NA	1.9e-02
17	TCGA	Prostate Adenocarcinoma	0.1073	0.0421	4.1e-06	0.029	0.075	0.066	NA	0.051	4.5e-04	3.0e-08	1.9e-07	NA	4.6e-06
18	TCGA	Thyroid Carcinoma	0.0860	0.0360	9.6e-06	0.075	0.050	0.053	NA	0.072	9.2e-08	1.2e-05	7.2e-06	NA	1.7e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Heart disease (siblings)	4.6	5.6	11.5	-2.0	-1.8	-2.3	-3.2	-2.5	-1.7	-1.8	-3.1	-3.4	-0.2	-2.1	-1.5	-2.3	-1.8	-2.5	-2.9	-3.2	-2.1
Lupus	4.0	6.1	13.7	1.7	3.4	3.0	-0.3	2.4	3.0	3.7	-3.1	0.0	2.3	3.5	3.2	-2.2	2.4	-0.2	-0.1	0.1	3.2
High blood pressure (mother)	4.0	5.7	9.6	2.6	2.5	2.6	1.7	2.7	1.8	2.6	1.5	2.8	2.0	2.4	2.6	1.1	1.8	3.1	2.5	3.0	2.6
Shortness of breath walking on level ground	3.9	4.6	7.0	2.4	2.6	2.1	1.5	2.6	1.3	2.6	0.7	2.2	1.5	2.6	2.5	1.8	2.0	2.2	2.6	1.6	2.6
Diabetes (mother)	3.3	4.2	6.6	2.2	2.5	2.4	1.4	2.3	1.2	2.3	0.8	2.0	2.1	2.6	2.4	1.5	1.7	2.1	2.1	1.9	2.2
Illnesses of mother	3.3	4.1	7.9	-2.5	-2.2	-2.3	-0.6	-2.4	-2.0	-2.4	-0.6	-1.9	-2.0	-2.4	-2.4	0.1	-1.5	-2.8	-1.8	-2.0	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.9	12.5	1.9	2.4	1.8	1.0	1.6	3.3	2.3	-1.9	-0.1	3.5	2.3	2.3	-0.5	2.5	1.2	0.0	-0.2	1.9
Osteoporosis (self-reported)	3.3	4.1	7.2	-2.5	-1.8	-1.9	-1.8	-2.2	-0.1	-1.9	-1.9	-2.6	-1.7	-1.9	-2.1	-2.0	-2.0	-2.4	-2.7	-1.8	-1.8
Headache pain in last month	3.1	5.4	8.8	2.2	2.6	2.2	2.4	2.7	2.2	2.8	0.6	2.2	1.2	3.0	3.0	2.3	2.1	1.7	2.3	2.3	2.6
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	11.7	-2.1	-1.0	-0.5	-2.4	-1.5	-0.7	-0.8	-3.4	-2.9	-0.8	-0.8	-1.4	-2.0	-1.5	-2.3	-3.3	-2.1	-1.2
Chronic bronchitis/emphysema (father)	3.0	3.5	8.4	-2.2	-1.9	-1.2	-0.6	-2.1	-0.7	-1.7	-2.0	-2.5	-1.5	-2.0	-2.4	-0.6	-2.5	-1.6	-2.9	-1.1	-2.1
Blood clot in the leg (DVT)	3.0	3.9	11.4	-2.0	-2.2	-2.2	-1.7	-1.9	-1.4	-2.1	-1.1	-2.1	-1.8	-2.1	-2.0	-1.1	-1.1	-3.4	-2.1	-1.6	-2.1
Average weekly champagne plus white wine intake	3.0	4.1	7.7	1.3	2.6	2.8	2.3	2.6	0.6	2.6	0.6	2.1	0.7	2.5	2.0	1.4	1.9	2.0	1.9	1.4	2.8
Diverticular disease/diverticulitis (self-reported)	2.9	3.5	6.4	2.2	2.5	2.3	1.2	2.2	1.8	2.3	0.6	1.7	1.6	2.2	2.2	-0.3	2.1	1.8	1.5	0.8	2.2
HbA1C	2.8	3.1	7.7	-2.8	-1.5	-0.9	-1.7	-1.4	0.4	-1.2	-1.6	-1.9	-2.6	-1.5	-2.4	-0.4	-2.4	-2.0	-2.3	-0.8	-1.4
Blood Platelet Count	2.8	32.8	376.4	-4.3	-3.3	-2.6	-5.0	-2.0	-19.4	-2.8	0.6	-1.2	-3.9	-2.5	-2.7	-9.7	-1.1	-1.4	-1.6	-1.9	-2.5
Medication for cholesterol	2.8	4.3	7.8	-2.4	-2.4	-2.0	-1.8	-2.1	-2.7	-2.3	-0.3	-1.6	-2.3	-2.5	-2.2	-0.5	-2.8	-1.7	-1.9	-1.8	-2.2
Fractured/broken bones in last 5 years	2.8	3.6	6.9	-2.0	-2.1	-1.9	-0.8	-2.3	-1.1	-2.4	-0.6	-2.0	-2.2	-2.4	-2.6	-0.9	-2.1	-1.9	-1.7	-1.2	-2.2
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	8.9	-1.9	-2.3	-2.3	-1.5	-1.8	-1.2	-2.1	-0.6	-1.8	-1.8	-2.1	-2.1	-0.8	-1.2	-3.0	-1.8	-1.2	-2.1
Average weekly fortified wine intake	2.5	2.9	4.5	1.7	1.5	1.7	1.7	1.6	1.8	1.6	1.5	2.0	1.4	1.7	1.8	1.6	1.8	2.0	2.1	1.8	1.4
Mood swings	2.4	4.3	7.9	2.8	2.1	2.0	2.2	1.7	2.2	1.9	1.1	2.1	1.6	2.1	2.8	2.1	1.7	1.8	1.9	2.8	1.7
Schizophrenia (2018)	2.3	4.7	14.3	2.8	2.3	0.0	2.4	1.9	2.4	2.2	0.4	1.6	3.2	1.8	2.5	1.4	3.8	1.2	1.8	2.1	1.9
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.0	2.2	2.0	1.1	1.9	1.5	1.3	1.7	0.8	1.7	2.2	2.2	1.7	1.2	1.7	1.8	2.0	1.1	1.9
Tinnitus: Yes, now most or all of the time	2.3	2.7	5.2	1.8	1.9	1.8	0.2	1.8	1.6	1.9	0.6	1.8	1.1	2.3	1.9	0.1	1.6	1.5	1.9	1.9	1.9
Medication: Lisinopril	2.3	2.9	7.9	1.7	2.0	1.7	0.2	1.8	1.7	2.0	-0.3	1.2	2.0	2.4	2.8	0.9	2.2	1.2	1.6	0.4	1.9
Pain experienced in last month	2.2	3.6	12.8	-1.4	-1.7	-1.8	-2.4	-1.9	-1.0	-1.6	-1.6	-2.3	0.2	-2.4	-1.1	-3.6	-1.2	-1.6	-2.2	-2.1	-1.7
Number of children fathered	2.1	2.3	8.1	-1.1	-1.4	-1.5	-2.8	-1.7	-1.7	-1.2	-0.9	-1.5	-0.5	-1.2	-0.6	-1.8	-1.9	-1.5	-1.9	-0.9	-1.6
Heart attack/myocardial infarction (self-reported)	2.1	2.8	8.5	-1.7	-1.5	-1.7	-1.2	-1.5	-1.8	-1.4	-1.2	-1.8	-1.6	-1.7	-1.6	0.2	-1.4	-2.9	-1.5	-2.2	-1.5
Father’s age at death	2.0	2.7	6.2	1.8	1.3	1.2	1.7	1.5	0.8	1.3	1.7	2.2	1.6	1.4	1.6	1.2	1.2	2.5	2.4	1.8	1.3
Age started oral contraceptive pill	2.0	2.5	6.0	2.1	1.1	0.7	0.8	1.1	1.1	0.8	2.4	2.1	1.8	1.5	1.2	1.2	1.4	1.9	2.5	1.9	1.0
Heart attack	1.9	2.5	8.3	-1.6	-1.5	-1.7	-1.0	-1.5	-1.6	-1.5	-1.0	-1.7	-1.5	-1.6	-1.6	0.4	-1.3	-2.9	-1.4	-2.0	-1.5
Smoking status: Previous	1.9	2.8	10.5	-1.7	-1.9	-2.1	-0.2	-1.9	-0.7	-2.1	-0.1	-1.3	-1.7	-1.7	-3.2	0.1	-1.8	-2.3	-1.1	-0.9	-1.9
Medication: Levothyroxine sodium	1.8	3.0	8.6	0.9	2.7	2.5	-0.1	2.1	1.5	2.8	-1.3	1.0	0.6	2.6	2.3	-0.6	0.6	1.3	0.3	0.4	2.9
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.2	-1.3	-1.9	-1.5	-1.2	-2.1	-1.7	-2.0	-0.4	-1.5	-0.5	-2.3	-1.5	-0.7	-1.4	-1.5	-1.6	-0.5	-2.0
Mouth/teeth dental problems: Loose teeth	1.8	2.2	4.4	-1.6	-1.6	-1.8	-1.5	-1.5	-2.1	-1.8	0.3	-0.9	-1.6	-1.9	-1.6	0.1	-1.7	-1.3	-0.7	-1.1	-1.5
Medication: Lansoprazole	1.7	2.0	6.7	0.2	1.7	1.8	-1.0	1.7	2.6	2.0	-1.8	-0.0	0.8	1.9	1.3	0.5	1.4	0.3	-0.2	0.3	1.7
Illnesses of father: None of the above (group 1)	1.7	2.1	5.5	1.5	1.4	1.3	1.5	1.5	0.5	1.4	1.5	1.9	0.6	1.4	1.5	0.4	0.6	2.4	1.8	1.8	1.5
Mean Putamen Volume	1.6	1.8	5.1	2.3	0.9	0.5	1.1	0.8	0.8	0.7	1.4	1.2	2.2	0.8	1.8	1.6	1.2	1.2	1.6	1.6	0.5
Hypothyroidism (self reported)	1.6	3.8	8.8	-0.5	2.7	2.8	-0.1	2.4	1.3	2.9	-2.9	-0.1	-0.5	2.8	2.5	-2.1	0.5	0.1	-0.9	-0.6	3.0
Health satisfaction	1.6	2.0	3.7	1.9	1.6	1.3	1.5	1.2	1.4	1.5	0.5	1.3	1.2	1.6	1.4	1.4	1.1	1.7	1.5	1.4	1.5
Ovarian Cancer	1.5	1.9	4.3	1.9	1.5	1.4	1.5	1.2	2.1	1.4	0.1	0.9	1.5	1.6	1.8	1.2	1.4	1.0	0.9	1.1	1.3
Number of incorrect matches in round	1.5	2.5	4.8	2.0	1.8	1.4	1.3	1.8	1.1	1.7	1.4	1.9	0.9	1.7	1.2	1.3	0.5	2.2	1.9	2.0	1.6
High blood pressure (siblings)	1.5	2.1	4.8	1.2	1.9	1.7	-0.5	1.5	1.9	1.9	-1.6	0.2	1.7	2.0	2.2	-0.6	1.7	0.4	0.2	-0.1	1.8
Medication: Blood pressure	1.5	2.9	7.1	2.6	1.8	1.0	0.2	1.4	1.6	1.6	0.5	1.4	2.3	1.9	2.6	0.4	2.7	1.0	1.9	1.3	1.6
Schizophrenia (2014)	1.4	3.0	7.6	2.1	2.0	0.0	1.5	1.6	1.6	1.9	0.4	1.4	2.5	1.4	1.9	1.1	2.8	1.7	1.6	1.6	1.9
Illnesses of father: Heart disease	1.4	1.9	3.8	-1.5	-1.8	-1.5	-0.1	-1.4	-1.1	-1.9	0.1	-1.1	-1.1	-1.9	-1.9	0.8	-0.7	-1.6	-1.0	-1.6	-1.8
Smoking Status	1.3	3.1	7.8	-1.4	-2.0	-2.3	-0.3	-2.2	-1.4	-2.3	-0.6	-2.0	-0.7	-2.1	-2.8	-0.9	-1.4	-2.0	-1.3	-1.4	-2.4
Past tobacco smoking	1.3	2.3	9.1	1.5	1.5	1.8	0.6	1.8	0.6	1.7	0.6	1.5	1.4	1.5	3.0	0.0	1.8	2.0	1.2	0.7	1.5
Prospective memory result	1.3	1.6	5.1	1.5	0.9	0.6	1.7	1.0	0.6	0.6	1.7	1.8	0.4	0.8	0.7	2.3	1.1	1.0	1.7	1.7	1.0
Hair/balding pattern: Pattern 4	1.3	3.1	6.4	1.2	2.4	2.2	1.9	2.5	0.6	2.3	0.5	1.7	0.1	2.3	1.5	1.6	1.7	0.7	1.9	1.6	2.3
Birth weight	1.3	2.9	8.2	-2.6	-1.3	-1.1	-1.1	-1.5	-1.8	-1.3	-1.7	-2.0	-1.4	-1.6	-2.9	-1.6	-2.0	-1.0	-2.0	-1.1	-0.9
Mean time to correctly identify matches	1.3	2.5	6.6	-0.9	-2.1	-2.0	-1.3	-1.8	-2.6	-2.3	1.0	-0.7	-1.1	-1.9	-1.6	-0.2	-1.7	-1.2	-0.8	-0.0	-2.2
Had major operations	1.3	1.5	3.0	-1.5	-1.2	-1.2	-0.6	-1.3	-1.4	-1.5	-0.6	-1.4	-0.7	-1.2	-1.5	-1.7	-0.2	-1.2	-1.2	-1.3	-1.2
Leg pain on walking	1.3	1.6	3.3	1.4	1.5	0.9	0.2	1.5	1.0	1.2	1.0	1.6	0.6	1.4	1.6	0.8	1.3	1.4	1.8	1.1	1.6
Ever smoked	1.3	2.3	8.6	-1.1	-1.6	-2.0	-0.0	-2.0	-0.4	-1.9	-0.4	-1.5	-0.9	-1.8	-2.9	-0.6	-1.5	-1.9	-1.4	-0.8	-1.7
Breast Cancer	1.2	2.8	14.8	-1.1	-0.0	-0.6	-1.5	-0.8	2.1	0.1	-3.9	-2.8	0.9	-0.6	-0.0	-1.2	0.8	-2.1	-2.4	-2.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.3	-1.0	-1.7	-2.1	-1.9	-2.1	-1.2	-1.8	-0.5	-1.5	-0.1	-1.8	-0.9	0.5	-1.0	-1.2	-1.4	-0.5	-1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.2	-0.1	-1.6	-1.9	0.0	-2.0	0.3	-1.7	-0.2	-1.3	0.4	-1.4	-1.2	-0.9	-0.1	-1.2	-1.1	-1.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	7.8	1.1	2.0	2.0	0.6	1.5	2.8	2.3	-1.1	0.6	1.3	2.2	1.5	-0.4	1.6	1.9	0.2	1.1	2.1
Hearing aid user	1.2	1.3	2.9	1.7	1.2	0.9	1.1	0.9	1.1	1.4	0.3	0.9	1.4	1.5	1.4	0.1	1.3	0.9	1.4	0.8	1.1
Reaction Time	1.1	2.0	4.8	-0.7	-2.1	-2.1	-1.1	-1.7	-1.7	-2.2	1.3	-0.5	-0.9	-1.9	-1.2	0.2	-1.1	-1.3	-0.5	0.5	-2.1
Fasting Glucose	1.1	1.3	3.5	-0.5	1.4	1.9	-0.2	1.4	1.3	1.6	-1.9	-0.5	0.1	1.3	0.8	-1.1	0.7	-0.3	-0.5	-1.1	1.3
Neuroticism (2016)	1.1	1.6	5.9	2.4	0.2	-0.0	1.5	-0.1	1.9	-0.1	1.5	1.0	1.5	0.5	0.9	2.0	1.0	0.8	1.4	1.7	-0.2
Ever had hysterectomy (womb removed)	1.1	1.2	2.8	1.4	1.3	1.0	-0.1	1.2	1.3	1.3	-0.3	0.6	0.8	1.6	1.2	-1.4	1.7	0.6	0.7	-0.6	1.0
Relative age voice broke	1.1	1.7	5.6	1.8	0.7	0.3	1.7	1.0	0.9	0.4	1.9	1.6	1.6	0.6	0.2	0.9	2.4	0.3	2.1	1.2	0.6
Multivitamins +/- minerals	1.1	1.3	3.1	0.9	1.4	1.0	-0.2	1.0	1.8	1.2	0.6	1.2	-0.2	1.7	1.4	0.2	1.1	0.9	1.1	1.4	1.6
Hair/balding pattern: Pattern 2	1.1	1.4	5.4	-1.2	-0.4	-0.6	-0.7	-0.8	0.8	-0.4	-2.3	-2.0	-0.4	-0.7	-0.8	-1.1	-1.2	-1.5	-1.5	-1.9	-0.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	6.7	-0.1	2.3	2.2	0.3	1.9	1.0	2.4	-1.9	0.3	-0.2	2.2	1.8	-0.6	-0.0	0.3	-0.2	-0.2	2.6
Migraine (self-reported)	1.1	1.4	3.6	0.4	1.6	1.4	-1.2	1.5	1.3	1.9	-1.0	0.5	0.1	1.7	1.3	-0.6	1.0	0.5	0.1	0.9	1.8
Mineral and other dietary supplements	1.1	1.5	3.0	1.4	1.5	1.3	1.7	1.5	0.9	1.5	0.5	1.2	1.3	0.9	1.6	0.8	0.9	1.2	1.1	0.5	1.3
Supplements: Calcium	1.1	1.2	3.3	-0.3	-1.4	-1.8	-0.8	-1.7	-0.6	-1.6	0.2	-0.8	-0.2	-1.4	-1.2	-0.5	-0.6	-1.2	-0.6	-0.5	-1.5
Stomach or abdominal pain in last month	1.0	1.3	5.7	1.3	1.0	1.0	0.5	1.0	1.8	0.9	0.1	0.6	1.4	1.0	1.8	-0.5	2.4	0.4	0.8	0.6	0.6
Alcohol usually taken with meals	1.0	1.7	8.4	-1.7	-1.0	-0.9	-1.2	-0.8	-2.9	-1.0	0.1	-0.4	-2.2	-0.9	-1.3	-1.3	-1.6	-0.9	-1.0	-0.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.0	-1.3	-0.9	-1.1	0.1	-1.2	-0.4	-1.1	-1.2	-1.6	-1.1	-1.0	-0.8	-0.5	-0.6	-2.0	-1.6	-1.6	-0.7
Miserableness	1.0	1.7	3.3	1.8	1.5	1.1	1.4	1.0	1.8	1.4	0.3	1.2	1.0	1.4	1.8	0.7	1.0	1.2	1.1	1.6	1.2
Medication: Atorvastatin	1.0	1.2	3.2	0.2	1.6	1.3	0.8	1.4	1.8	1.7	-1.4	0.1	0.3	1.5	0.9	-0.2	1.2	0.6	0.3	-0.4	1.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	5.3	0.3	0.9	0.3	-0.0	0.4	2.1	1.1	-2.3	-1.0	2.1	1.4	0.6	-0.4	0.7	0.3	-0.5	-0.6	0.8
Blood White Count	0.9	6.3	13.2	-2.2	-2.6	-2.4	-2.9	-2.7	-1.3	-2.5	-2.3	-3.1	-0.2	-2.3	-2.2	-3.6	-1.4	-3.2	-3.3	-2.2	-2.7
Relative age of first facial hair	0.9	1.8	5.4	-1.2	-1.6	-1.7	-0.5	-1.4	-0.5	-1.5	0.0	-1.2	-0.8	-1.8	-2.3	-1.3	-0.6	-1.7	-1.0	-1.1	-1.7
Fed-up feelings	0.9	1.6	5.3	2.0	1.2	0.7	0.6	0.9	2.3	1.3	-0.3	0.5	1.4	1.0	2.2	0.5	1.6	0.8	0.8	0.8	0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.3	-1.2	-0.9	-1.0	-0.9	-0.9	0.4	-0.9	-0.6	-1.1	-1.7	-0.8	-1.5	-0.4	-0.6	-2.1	-1.0	-0.5	-0.8
Illnesses of siblings: Diabetes	0.9	1.1	2.6	1.2	1.6	1.6	0.6	1.5	1.2	1.4	-0.8	0.5	0.3	1.0	1.2	-0.3	0.7	0.7	0.7	0.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.4	0.6	1.7	1.8	-0.9	1.6	1.0	1.8	-0.5	0.9	0.9	1.4	1.8	0.1	1.6	1.5	0.8	1.3	1.8
Osteoarthritis (self-reported)	0.9	1.2	4.3	0.4	0.9	0.9	0.6	1.2	0.5	1.1	1.1	1.6	0.1	1.6	-0.2	0.8	0.6	1.2	2.1	1.4	1.3
Alzheimer’s Disease (in mother)	0.8	1.0	3.1	0.2	1.0	1.1	-0.2	0.9	0.4	1.2	-1.4	-0.3	1.4	1.3	0.9	-1.8	1.3	0.9	-0.3	0.1	0.8
Lung FEV1/FVC ratio	0.8	4.2	11.2	-2.4	-2.3	-2.1	-3.3	-2.2	-0.4	-2.2	-1.2	-2.0	-1.8	-2.0	-2.2	-2.7	-2.0	-1.3	-1.9	-1.1	-1.9
Medication: Co-codamol	0.8	0.9	4.9	0.6	0.5	0.3	-0.8	0.0	2.2	0.7	-1.1	-0.2	1.9	0.8	1.0	0.6	1.0	0.8	-0.2	0.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	6.0	0.7	1.0	0.9	0.3	0.9	0.2	1.0	-0.6	0.3	0.8	0.9	1.0	-2.5	1.8	0.3	0.5	-0.4	1.0
Supplements: Glucosamine	0.8	1.1	2.4	-1.5	-1.1	-0.9	-0.9	-1.3	0.1	-0.8	-1.0	-1.1	-1.3	-0.4	-1.1	-1.3	-1.2	-0.4	-1.6	-0.9	-0.7
Had menopause	0.8	1.0	2.4	1.6	1.1	0.9	0.9	0.9	0.4	0.9	0.6	0.9	1.2	1.3	1.0	1.2	1.3	0.6	1.5	0.2	0.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	6.0	1.2	-0.6	-0.7	0.9	-0.6	1.4	-0.5	1.0	0.2	2.4	-0.6	0.6	0.6	1.1	1.1	0.7	0.5	-1.0
Illnesses of siblings	0.8	1.1	5.9	-0.2	-0.4	-0.1	1.3	0.1	-0.7	-0.4	2.4	1.5	-0.7	-0.0	-0.6	1.2	-0.3	1.2	1.0	2.0	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.3	-1.0	-1.1	-1.2	0.3	-1.4	0.3	-1.2	-0.2	-1.1	-1.4	-1.0	-2.1	-0.7	-0.8	-1.4	-1.1	-0.7	-1.2
Exposure to tobacco smoke outside home	0.8	1.0	2.3	-0.9	-1.1	-1.4	-1.5	-1.4	0.1	-1.2	-1.0	-1.1	-0.3	-0.9	-1.1	-0.2	-1.3	-1.0	-1.0	-0.6	-0.9
Medication for pain relief, constipation, heartburn	0.8	1.3	3.4	-1.4	-0.8	-0.3	-0.9	-0.7	-1.8	-0.7	-0.3	-0.8	-1.8	-0.9	-0.8	-1.8	-1.3	-1.1	-1.2	-1.3	-0.6
Knee pain experienced in last month	0.8	1.2	2.5	-0.1	1.1	1.4	0.3	1.6	-0.0	1.3	0.5	1.4	-0.7	1.3	0.0	1.4	-0.4	1.3	1.6	1.0	1.5
Eye problems/disorders: Cataract	0.8	0.9	3.8	-0.9	-0.4	-0.1	0.8	-0.3	-1.6	-0.7	0.1	-0.3	-1.6	-0.5	-0.5	1.6	-1.0	-1.9	-0.2	-0.9	-0.5
Illnesses of father: High blood pressure	0.8	1.0	3.2	1.3	1.1	0.7	-0.4	0.6	1.0	1.0	-0.7	0.2	1.8	0.8	1.8	-0.5	1.8	0.2	0.5	0.6	0.9
Number of operations (self-reported)	0.8	1.2	4.2	-0.3	-0.5	-1.1	0.7	-1.0	-0.1	-0.8	-1.3	-1.6	-0.1	-0.9	-0.9	-2.0	-0.0	-1.6	-1.2	-1.5	-0.7
Bipolar Disorder (2018)	0.7	1.1	4.3	-1.0	-1.1	0.0	-0.5	-0.9	-0.3	-1.3	0.2	-0.6	-1.4	-1.6	-2.1	0.3	-1.2	-0.8	-0.9	-0.8	-1.1
Age at First Birth	0.7	1.0	4.7	0.7	0.4	0.3	1.8	0.7	2.2	0.7	0.5	0.8	0.6	0.9	0.5	0.9	1.5	0.3	1.4	0.5	0.5
Primary Biliary Cirrhosis	0.7	1.0	7.9	-0.6	0.5	0.6	-0.8	0.4	0.5	0.9	-2.8	-1.6	0.2	0.6	-0.0	-1.3	-0.6	-0.8	-1.5	-0.5	0.5
Rheumatoid Arthritis	0.7	1.0	2.9	-1.4	-0.5	-0.2	-0.6	-0.6	-0.1	-0.4	-1.7	-1.4	-1.2	0.1	-0.4	-0.6	-0.6	-1.7	-1.4	-1.6	-0.4
Waist Hip Ratio (WHR)	0.7	3.0	16.6	-1.1	0.7	0.4	-1.0	-0.1	1.1	0.6	-4.1	-2.4	1.4	0.4	-0.2	-3.8	1.2	-1.1	-2.4	-1.7	0.3
Allergy or Eczema	0.7	1.8	10.1	2.3	0.4	-0.0	1.3	-0.1	2.1	0.1	1.0	0.5	3.2	0.1	1.0	-0.5	2.4	1.2	0.7	1.0	-0.3
Medication for hormone replacement therapy	0.7	0.8	2.8	0.5	0.9	0.8	0.5	0.7	1.4	0.7	0.4	0.8	0.6	0.9	0.1	-0.3	0.2	1.7	0.7	1.6	0.8
Diabetes (father)	0.7	0.9	2.0	-0.8	-0.5	-0.6	-1.0	-0.7	-1.4	-0.6	-1.0	-1.0	-1.2	-0.4	-0.4	-1.4	-1.1	-1.1	-1.2	-0.9	-0.3
Impedance of leg (right)	0.7	3.2	9.0	1.9	1.6	1.5	3.0	1.9	-0.1	1.2	2.1	2.2	1.3	1.7	1.4	1.0	1.9	1.8	2.5	1.9	1.1
Hand grip strength (right)	0.7	1.9	8.1	-0.8	1.4	1.8	-1.3	0.9	-0.6	1.7	-2.9	-0.9	-0.6	0.9	0.7	-2.0	0.1	-1.0	-1.5	-1.6	1.4
Maternal smoking around birth	0.7	1.1	4.8	1.8	1.0	0.4	0.5	0.3	1.3	0.7	0.3	0.7	2.2	0.6	1.1	0.2	1.2	1.2	0.8	1.0	0.6
Taking other prescription medications	0.7	1.1	5.4	1.0	0.7	-0.1	-0.2	0.1	1.3	0.7	-1.9	-1.0	2.3	0.7	1.1	-0.6	1.3	-0.3	-1.2	-1.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.9	1.0	0.6	0.3	1.4	0.4	-0.1	0.4	0.3	0.7	1.7	0.5	0.6	2.0	0.6	0.7	0.8	-0.2	0.6
Impedance of leg (left)	0.7	3.3	8.4	2.2	1.8	1.7	2.9	1.9	0.2	1.4	1.7	2.0	1.8	1.9	1.5	0.9	2.3	1.8	2.1	1.9	1.2
Had other major operations	0.7	0.8	4.0	0.2	0.0	-0.4	0.3	-0.4	0.6	0.1	-2.0	-1.6	0.9	-0.4	-0.5	-0.8	0.1	-1.2	-1.2	-1.5	-0.2
Neuroticism score	0.7	1.4	3.2	1.8	1.2	0.8	1.3	0.8	1.7	1.0	0.1	0.7	1.1	1.2	1.8	1.4	1.2	0.4	1.0	1.4	0.9
Alcohol intake versus 10 years previously	0.7	1.0	2.6	-1.2	-1.2	-1.1	0.3	-1.1	-0.1	-1.3	-0.6	-1.2	-1.1	-0.8	-1.1	0.4	-0.2	-1.6	-0.8	-1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	1.0	5.6	-1.1	-0.4	-0.1	-2.0	-0.4	-0.2	-0.2	-0.6	-0.3	-1.3	-0.4	-0.9	-1.1	-2.4	-0.2	-1.2	-0.0	-0.1
Lung cancer (father)	0.7	0.8	2.0	-0.1	-0.7	-1.1	-0.4	-1.1	0.1	-0.7	-1.1	-1.4	0.7	-1.1	-0.7	-1.2	-0.5	-0.9	-0.9	-1.1	-1.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-0.1	-0.9	-1.3	-1.3	-1.2	0.6	-0.9	-0.8	-1.1	0.8	-0.7	-0.4	-1.4	-0.6	-0.2	-1.0	0.1	-0.9
Family relationship satisfaction	0.7	0.9	2.6	-0.8	-1.0	-0.9	0.9	-0.6	-1.6	-1.0	0.9	0.1	-1.2	-0.8	-1.6	1.2	-1.2	-0.2	0.3	-0.2	-0.9
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.3	-0.3	-1.1	-1.5	-0.4	-1.0	-0.9	-1.3	1.1	0.0	-1.3	-0.9	-1.1	-0.7	-0.9	-0.3	-0.0	0.3	-1.0
Qualifications: nursing, teaching	0.7	1.0	3.7	-0.6	-1.0	-1.0	-0.4	-1.1	-0.4	-0.9	-1.1	-1.4	0.5	-1.1	-0.6	-1.9	-0.1	-0.8	-1.2	-1.3	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.8	4.9	0.2	-0.3	-0.3	1.1	-0.0	-0.6	-0.4	1.7	0.9	-0.5	-0.2	-1.0	2.2	-0.8	0.6	1.2	0.8	-0.3
Unable to work because of sickness or disability	0.7	1.0	3.3	-0.5	-0.8	-1.0	-0.2	-1.0	-0.7	-0.7	-1.6	-1.6	-0.2	-0.5	-0.5	-0.1	0.1	-1.8	-0.9	-1.7	-0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	3.4	0.2	0.4	0.5	-1.0	0.3	1.1	0.7	-1.7	-0.8	1.5	0.9	0.3	-1.8	1.1	0.3	-0.7	-0.5	0.1
HDL Cholesterol	0.6	1.1	5.3	0.5	-0.9	-0.7	1.9	-0.6	-1.0	-0.8	2.3	1.0	-0.6	-1.0	-0.9	1.6	-1.0	0.0	0.0	0.0	0.0
Neuroticism	0.6	1.6	4.1	1.6	1.1	0.9	2.0	0.7	2.0	0.8	-0.1	0.5	1.7	0.9	1.4	1.3	1.3	1.1	0.8	1.6	0.6
Chronotype (morning person)	0.6	1.4	4.0	1.1	1.8	1.5	-0.3	1.4	0.8	1.8	-0.7	0.9	0.4	2.0	1.7	0.4	0.5	0.5	0.5	0.2	2.0
Pack years adult smoking proportion	0.6	0.8	3.9	0.2	-0.5	-0.4	0.9	-0.4	-1.3	-0.8	1.3	0.5	-1.2	-0.6	-0.1	2.0	-1.5	-0.7	0.7	0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.1	2.1	0.2	-0.2	1.5	-0.2	1.9	-0.1	1.3	0.6	2.3	-0.2	0.8	-0.0	1.6	1.2	0.8	0.9	-0.3
Mouth/teeth dental problems	0.6	0.9	1.9	0.9	0.9	0.8	0.6	1.0	0.5	0.8	1.4	1.4	1.1	0.9	0.8	-0.0	1.4	1.3	1.1	0.7	0.8
Medication: Ramipril	0.6	0.7	2.4	0.2	-1.1	-1.6	-0.2	-1.3	0.1	-1.0	-0.3	-0.9	0.4	-1.0	-0.5	-0.6	0.3	-1.0	-0.6	-1.1	-1.2
Noisy workplace	0.6	0.7	1.7	-0.0	-0.8	-1.2	-0.7	-1.3	-0.6	-0.9	-0.2	-0.7	-0.7	-0.7	-0.5	-0.6	-1.0	-1.0	-1.1	-1.1	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	3.7	0.1	0.4	0.3	-0.4	0.2	0.4	0.4	-1.8	-1.1	1.5	0.4	0.1	-1.9	0.5	-0.2	-1.1	-0.4	0.2
Exposure to tobacco smoke at home	0.6	0.7	1.7	-0.7	-1.3	-1.2	-1.0	-1.0	-1.1	-1.0	-0.2	-0.7	-0.2	-0.9	-1.0	-0.2	-0.6	-0.8	-0.3	-0.3	-1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.9	0.3	0.2	0.2	0.2	0.4	1.5	0.3	1.1	1.1	-1.0	0.4	-0.1	2.0	0.2	0.6	1.2	1.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	6.4	1.2	0.6	0.4	-0.4	0.5	1.1	0.5	-0.1	-0.0	2.5	0.9	1.2	-1.4	1.5	1.0	-0.3	0.3	0.3
Medication: Paracetamol	0.6	1.0	6.6	0.7	-0.6	-1.0	1.5	-0.3	0.5	-0.7	1.4	0.5	0.3	-0.5	-0.7	2.6	0.6	-0.1	1.1	0.7	-0.7
Worry too long after embarrassment	0.6	1.0	2.4	1.3	0.9	0.8	1.4	0.8	0.9	0.8	0.6	0.8	0.6	1.0	1.1	1.6	1.4	-0.2	1.0	1.1	0.7
Angina (self-reported)	0.6	0.8	2.5	1.0	1.2	1.0	0.9	1.0	0.2	1.1	-0.4	0.5	0.6	1.1	1.0	1.6	0.8	-0.4	1.0	0.1	1.1
Medication: Omeprazole	0.6	0.7	3.6	-0.1	0.3	-0.0	-0.5	-0.0	1.9	0.6	-1.9	-1.2	1.2	0.8	0.2	-0.3	0.4	-0.2	-0.5	-0.9	0.3
Age at last live birth	0.6	0.8	3.1	-1.6	-0.7	-0.3	-0.1	-0.4	-1.4	-0.7	-0.0	-0.4	-1.7	-1.1	-0.9	-0.5	-1.3	-0.6	-0.3	-1.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.8	-0.8	-1.2	-1.3	0.1	-1.3	0.5	-1.0	-1.0	-1.2	-0.4	-1.1	-1.0	0.3	-0.5	-1.1	-0.9	-1.1	-1.3
Irritability	0.6	1.0	2.0	1.4	1.1	0.8	0.3	0.9	0.7	0.8	0.6	1.1	0.7	0.5	1.2	1.1	1.4	1.3	1.1	1.1	0.9
Cholesterol lowering medication	0.6	0.9	3.5	1.0	1.2	1.0	0.7	1.3	0.7	1.2	-0.3	0.5	1.0	0.9	0.8	0.9	1.9	-0.4	0.9	-0.2	1.2
Bipolar Disorder or Schizophrenia	0.5	1.3	4.5	1.5	1.1	0.0	1.6	0.9	1.6	0.9	0.4	0.8	1.5	0.5	0.7	1.3	2.1	0.5	0.8	1.0	0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.2	0.0	-0.5	-0.6	-0.6	-0.9	1.0	-0.5	-0.9	-1.0	0.7	-0.5	-0.8	-0.9	-0.0	-0.6	-1.0	-1.1	-0.9
Prostate Cancer	0.5	0.7	4.6	0.2	-0.6	-0.9	-1.1	-0.4	-2.1	-0.7	1.2	0.6	-0.4	-0.7	-0.1	0.5	-0.2	0.4	0.4	1.0	-0.3
Body Mass Index (BMI) (2010)	0.5	0.7	5.4	-2.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.2	-2.3	-1.1	0.0	0.0	0.0	0.0
LDL Cholesterol	0.5	0.8	3.6	0.6	0.8	0.4	0.0	0.4	1.1	0.5	-1.7	-0.8	1.9	0.6	1.0	-1.6	0.9	0.0	0.0	0.0	0.0
Blood Red Count	0.5	5.0	20.5	-2.2	-1.7	-1.4	-2.1	-1.5	-3.0	-1.5	-2.0	-2.4	-1.9	-1.2	-1.2	-4.5	-1.7	-3.1	-1.9	-2.8	-1.5
Systolic Blood Pressure	0.5	2.6	9.7	2.0	0.0	-0.0	1.2	0.7	1.4	0.2	3.1	2.2	0.9	0.5	1.0	2.2	1.4	1.0	2.6	2.6	0.1
Cardiovascular Disease	0.5	1.6	6.7	1.9	1.1	0.2	1.2	0.6	2.0	1.0	-0.3	0.5	2.2	1.2	1.6	0.2	2.6	-0.1	0.9	0.7	0.8
Lung FVC	0.5	2.3	5.7	1.6	2.3	2.2	1.4	1.7	1.4	2.4	-0.9	0.8	0.4	2.2	1.8	-0.2	0.9	1.0	0.2	0.4	2.2
Hand grip strength (left)	0.5	1.4	6.3	-1.2	1.0	1.2	-1.5	0.5	-0.2	1.3	-2.5	-0.9	-0.8	0.5	0.3	-1.9	-0.2	-0.8	-1.4	-1.3	1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.4	0.3	0.5	0.1	0.8	0.4	-0.5	0.0	1.4	1.2	-0.6	-0.2	-0.0	0.8	0.4	0.9	1.5	0.8	0.6
Vitamin and mineral supplements	0.5	0.7	1.9	-0.1	-0.9	-0.8	0.9	-0.7	-1.2	-0.9	0.3	-0.5	0.2	-1.4	-1.2	0.2	-1.1	-0.4	-0.4	-1.0	-1.1
Supplements: Zinc	0.5	0.5	1.8	1.2	0.2	-0.1	-0.4	-0.1	1.3	0.1	-0.3	-0.1	1.4	0.0	1.3	-0.2	1.1	0.5	0.4	1.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	0.8	1.2	0.9	0.3	0.9	1.0	1.1	-0.9	0.1	0.4	0.7	1.3	1.1	0.4	0.3	0.2	0.8	1.0
Qualifications: CSEs or equivalent	0.5	0.7	2.9	0.1	0.9	1.2	-0.8	0.7	1.7	1.1	-1.3	-0.3	0.5	0.9	0.9	-0.8	0.2	0.4	-0.2	-0.0	1.0
Number of full brothers	0.5	0.6	2.2	-0.0	0.2	-0.1	-0.9	0.1	1.4	0.4	-1.3	-0.8	1.1	0.3	0.5	-1.5	0.2	0.4	-0.5	-1.0	0.2
Pulse wave peak to peak time	0.5	0.6	2.9	-0.2	-0.2	-0.2	0.2	-0.1	-0.6	-0.3	1.6	1.0	-1.4	-0.3	0.1	1.7	-0.6	0.2	1.0	0.2	0.0
Medication: Ibuprofen	0.5	0.6	4.6	-0.9	-0.2	0.0	-1.5	-0.1	-0.2	-0.2	0.2	0.3	-1.1	-0.1	-0.8	-1.1	-2.1	0.4	-0.7	0.4	0.1
Pulse rate, automated reading	0.5	1.7	7.2	1.3	1.0	0.8	1.3	1.1	0.4	0.8	1.6	1.5	0.7	0.8	0.3	1.5	1.1	1.5	1.7	2.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	2.9	0.8	0.8	0.6	-0.5	0.7	1.7	0.7	-0.7	0.0	0.1	0.7	1.1	-1.0	0.7	-0.1	-0.1	0.2	0.6
Back pain experienced in last month	0.5	0.7	2.7	1.1	0.3	0.2	0.5	0.1	-0.0	0.1	1.3	1.0	1.0	0.7	0.6	1.7	0.4	1.5	0.8	0.9	0.0
Medication: Aspirin	0.5	0.6	3.5	0.7	0.6	0.4	0.5	0.2	0.6	0.6	-1.6	-0.8	1.9	0.6	0.7	0.2	0.9	0.0	-0.5	-0.1	0.2
Number of self-reported non-cancer illnesses	0.5	0.8	5.6	1.8	0.3	-0.8	1.0	-0.6	1.1	0.1	-0.1	-0.2	2.4	0.0	0.8	-0.1	1.3	0.2	0.1	-0.6	-0.2
Triglycerides	0.4	0.7	4.7	-0.9	0.6	0.6	-0.2	0.4	0.5	0.6	-2.2	-1.4	-0.5	0.5	-0.1	-1.7	0.2	0.0	0.0	0.0	0.0
Respiratory disease	0.4	0.9	3.4	1.6	0.3	-0.1	1.8	0.0	-0.3	0.1	1.4	1.0	1.6	0.5	0.7	0.5	1.3	0.9	1.0	0.5	0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.0	0.2	-0.1	-0.3	1.4	-0.1	-1.7	-0.6	1.3	0.6	0.0	-0.4	-0.7	1.0	-0.1	0.6	0.9	1.3	-0.3
Sensitivity / hurt feelings	0.4	0.8	5.0	-0.6	-0.2	-0.2	-0.9	-0.4	-0.4	-0.2	-2.2	-1.5	-0.6	0.2	0.1	-0.9	-0.6	-1.3	-1.0	-0.8	-0.3
Hearing difficulty/problems: Yes	0.4	0.7	2.5	-0.6	0.6	1.0	-1.3	0.6	0.1	1.0	-1.4	-0.3	-0.0	1.0	-0.1	-1.6	-0.8	0.5	-0.3	-0.5	0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	3.4	1.0	0.7	0.2	0.0	0.4	0.7	0.7	-0.5	-0.1	1.9	0.5	1.3	0.7	0.6	0.5	0.6	-0.1	0.5
Angina	0.4	0.5	2.3	0.7	0.9	0.7	0.7	0.7	-0.2	0.8	-0.4	0.4	0.1	0.8	0.7	1.5	0.5	-0.8	0.8	-0.1	0.8
Age when periods started (menarche)	0.4	1.0	2.7	-1.1	-1.3	-0.9	-0.6	-0.9	-0.5	-1.4	0.6	-0.5	-1.5	-1.2	-1.6	-0.5	-1.3	-0.4	-0.4	0.7	-1.4
Medication: Atenolol	0.4	0.5	2.0	-0.3	0.3	0.3	-1.1	-0.1	-1.0	0.1	-1.4	-0.8	-0.6	-0.0	0.6	-0.4	-0.3	-1.3	-0.8	-0.4	0.2
Fluid intelligence score	0.4	0.8	2.9	-0.6	1.0	1.5	0.4	1.1	-0.3	1.2	-1.1	-0.0	0.3	1.0	0.2	-1.7	0.9	0.1	-0.4	-0.3	1.0
Time employed in main current job	0.4	0.5	2.7	1.0	0.6	0.4	0.2	0.3	1.6	0.5	0.2	0.4	0.8	0.5	1.2	0.8	0.7	0.5	0.2	0.1	0.5
Worrier / anxious feelings	0.4	0.7	3.2	0.3	-0.6	-0.6	1.8	-0.5	-0.5	-0.9	1.1	0.2	-0.9	-0.5	-0.6	1.7	-0.2	-0.8	0.7	0.7	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.1	-1.1	-1.1	-0.3	-1.1	-1.2	-1.0	1.0	0.2	0.5	-1.0	-0.0	0.9	-0.7	0.2	0.1	0.2	-1.0
Pulse rate	0.4	0.7	3.2	0.9	0.3	0.2	0.8	0.5	0.8	0.2	1.5	1.1	0.4	0.4	0.1	0.4	1.1	1.0	1.0	1.8	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	11.0	-0.2	0.1	0.1	-0.9	-0.1	1.0	0.2	-0.9	-0.7	0.1	0.0	0.2	-3.3	0.8	-0.4	-0.8	-1.0	0.1
Depression (self-reported)	0.4	0.5	2.1	0.2	-0.2	-1.0	1.1	-0.5	-0.1	-0.6	-0.2	-0.6	-1.0	-0.9	-0.4	0.6	-0.1	-1.5	-0.0	-1.0	-0.4
Pulse wave reflection index	0.4	0.4	2.9	0.7	0.3	0.0	0.4	-0.1	0.4	0.2	-1.1	-0.7	1.7	0.4	0.6	-0.5	0.8	-0.5	-0.9	-0.4	-0.1
Loud music exposure frequency	0.4	0.5	1.9	0.1	1.1	1.2	0.3	0.6	1.4	0.9	-0.7	0.2	0.2	1.0	0.5	0.5	-0.1	0.5	0.1	-0.0	0.8
Comparative body size at age 10	0.4	1.0	3.8	-0.9	0.2	0.2	-2.0	0.0	0.9	0.4	-1.9	-1.1	-0.0	0.3	-0.1	-1.5	-0.3	-1.0	-1.3	-1.6	0.7
Wheeze or whistling in the chest in last year	0.4	0.7	3.8	0.4	0.0	-0.5	-0.8	-0.7	0.4	0.0	-1.9	-1.5	1.0	-0.1	0.1	-0.2	0.2	-0.9	-1.2	-0.9	-0.3
Eye problems/disorders: None of the above	0.4	0.5	2.2	0.5	-0.7	-0.9	-0.4	-0.7	1.5	-0.5	0.9	0.2	0.5	-0.6	-0.5	-1.2	-0.0	0.8	0.1	0.6	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	-0.1	0.9	1.1	0.4	1.2	0.7	1.0	0.1	0.7	-0.3	0.6	-0.0	1.3	0.1	0.1	0.9	0.5	0.8
Alcohol intake frequency.	0.4	0.9	2.7	-0.9	-1.2	-1.4	-0.5	-0.8	-1.6	-1.0	0.0	-0.7	-1.1	-1.2	-0.5	-0.5	-0.5	-0.8	-0.1	-1.2	-0.9
Chest pain or discomfort	0.4	0.5	1.9	-0.1	-0.3	-0.4	0.3	-0.6	1.2	-0.4	-1.3	-1.1	0.4	-0.3	-0.3	0.4	0.2	-1.4	-1.0	-0.6	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	0.2	-0.9	-1.0	-0.6	-0.9	1.1	-0.9	0.1	-0.4	1.3	-0.8	-0.1	-0.5	0.7	-0.4	-0.5	-0.0	-1.0
Medication: Aspirin	0.4	0.6	3.1	0.7	0.8	0.5	0.5	0.3	0.6	0.7	-1.8	-0.8	1.6	0.7	0.6	0.1	0.7	-0.0	-0.5	-0.1	0.4
Leg fat-free mass (right)	0.4	2.1	7.4	-1.9	-0.3	-0.3	-2.7	-0.7	-0.5	0.0	-2.7	-1.7	-1.1	-0.6	-0.7	-1.1	-1.4	-1.1	-2.2	-1.8	0.3
Loneliness, isolation	0.4	0.5	1.9	0.0	0.9	0.7	0.4	0.7	1.4	0.9	-0.3	0.4	-0.1	0.8	0.8	0.9	0.2	0.8	0.4	0.1	1.1
Breast cancer (self-reported)	0.4	0.5	1.6	0.8	0.6	0.6	0.6	0.8	-0.9	0.6	0.7	0.8	-0.4	0.4	0.7	-0.0	-0.2	0.4	1.3	0.7	0.6
Leg predicted mass (right)	0.4	2.2	8.0	-2.0	-0.3	-0.3	-2.8	-0.7	-0.6	-0.0	-2.8	-1.8	-1.1	-0.6	-0.7	-1.2	-1.4	-1.2	-2.3	-1.9	0.2
Wears glasses or contact lenses	0.4	0.4	0.9	0.8	0.8	0.8	0.8	1.0	-0.2	0.8	0.3	0.6	0.0	0.8	0.6	0.5	0.4	0.4	0.7	0.6	0.7
Ever taken oral contraceptive pill	0.4	0.4	1.5	-0.1	-0.0	0.3	0.6	0.2	0.1	0.2	0.9	0.8	-0.4	0.4	-0.7	1.2	-0.8	1.0	0.4	1.1	0.1
Mother’s age at death	0.4	0.6	2.3	-0.6	-0.7	-0.6	0.3	-0.3	-1.5	-0.8	0.9	0.1	-1.2	-0.5	-1.2	-0.4	-0.3	-1.0	0.1	-0.3	-0.6
Commuting to job workplace: Public transport	0.4	0.4	1.7	0.9	0.4	0.8	1.3	0.2	0.3	0.1	1.0	0.7	0.8	0.0	0.1	-0.2	0.9	1.0	0.3	0.7	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.7	1.1	0.5	0.2	0.1	0.6	-0.1	0.5	0.1	0.4	1.2	0.8	0.9	0.3	1.7	0.1	0.6	0.0	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.2	-0.9	-0.7	-0.4	-0.8	-1.1	-1.2	1.2	0.1	-0.7	-0.5	-0.9	0.3	-0.3	0.0	0.4	0.7	-0.8
Alcohol drinker status: Never	0.4	0.5	1.3	-1.1	-0.6	-0.5	-0.5	-0.5	-1.0	-0.6	-0.4	-0.7	-0.6	-0.7	-0.7	-0.7	-0.6	0.1	-0.8	-0.9	-0.3
Arm fat-free mass (left)	0.4	1.9	10.0	-1.7	0.7	0.6	-2.2	0.1	-0.0	0.9	-3.2	-1.5	-0.9	0.3	-0.5	-0.8	-1.1	-0.8	-1.9	-1.7	1.1
Ever depressed for a whole week	0.4	0.5	2.9	-0.4	-0.0	-0.3	-0.4	-0.3	1.0	-0.0	-1.4	-1.2	-0.3	-0.1	-0.7	-0.6	0.3	-1.7	-0.8	-0.6	-0.2
Pack years of smoking	0.4	0.6	3.2	0.3	-0.1	-0.0	1.1	-0.0	-1.0	-0.3	1.1	0.6	-0.9	-0.2	0.1	1.8	-1.1	-0.6	0.7	0.6	0.0
Impedance of whole body	0.4	1.9	6.6	2.0	0.7	0.6	2.6	1.0	-0.0	0.4	2.0	1.4	1.7	1.0	1.3	0.0	2.1	1.3	1.7	1.3	0.1
Worry (Nagel 2018)	0.3	0.7	3.8	1.2	0.4	-0.3	1.6	0.1	0.6	-0.0	0.1	-0.0	1.0	0.2	0.7	2.0	0.9	-0.1	0.8	0.7	-0.0
Ulcerative Colitis (UC)	0.3	0.6	1.6	-0.7	-1.0	-1.1	-1.3	-1.0	-0.8	-0.9	-0.0	-0.6	-0.5	-0.3	-0.2	0.3	-1.0	-0.5	-0.7	-0.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.1	-0.0	1.3	1.4	0.4	1.2	0.0	1.4	-1.5	-0.3	0.7	1.3	0.5	-0.8	0.9	0.2	-0.3	-0.4	1.2
Ulcerative Colitis	0.3	0.4	1.6	0.7	-0.3	0.0	-0.2	-0.3	-0.5	-0.5	1.2	0.4	1.3	-0.0	0.6	1.2	-0.2	0.5	0.7	0.8	-0.5
Blood Eosinophil Count	0.3	2.4	5.2	1.6	2.0	2.3	1.9	1.4	1.6	1.8	-0.3	1.0	1.9	1.5	1.7	-0.8	1.4	1.7	0.5	1.5	1.6
Number of treatments/medications taken	0.3	0.5	2.2	0.5	0.1	-0.7	-1.1	-0.4	0.8	0.2	-1.5	-0.9	0.9	0.2	0.5	-0.8	0.4	-0.8	-0.9	-0.9	-0.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.0	0.8	0.3	-0.1	-0.2	0.1	0.9	0.1	0.5	0.5	-0.1	-0.3	0.8	1.4	-0.1	0.5	0.4	1.1	0.1
Systolic blood pressure, automated reading	0.3	0.8	2.7	1.2	0.4	0.3	0.6	0.6	1.1	0.5	1.6	1.4	-0.3	0.5	0.2	1.4	0.4	0.5	1.2	0.9	0.5
Leg fat-free mass (left)	0.3	1.6	6.5	-1.7	-0.2	-0.1	-2.4	-0.5	-0.4	0.2	-2.5	-1.5	-1.0	-0.5	-0.5	-0.8	-1.4	-1.0	-1.8	-1.6	0.4
Trunk fat percentage	0.3	1.1	4.3	0.7	1.1	0.7	-0.6	0.5	1.6	1.3	-2.1	-0.7	1.8	1.0	0.5	-0.8	0.9	0.5	-0.5	-0.7	1.1
Current tobacco smoking	0.3	0.5	1.9	0.9	-0.1	-0.5	1.1	-0.1	-0.7	-0.4	1.4	0.7	0.3	-0.5	-0.4	0.3	0.4	-0.0	1.2	0.7	-0.5
High blood pressure	0.3	1.0	3.8	1.8	1.0	0.2	0.2	0.6	0.4	0.9	-0.2	0.4	1.3	1.3	1.4	0.2	2.0	-0.2	0.9	0.7	0.8
Sitting height	0.3	2.3	7.7	-1.1	1.9	2.1	-0.7	1.6	0.5	2.2	-2.8	-0.4	-0.7	1.9	1.0	-1.7	0.2	-0.3	-1.2	-1.1	2.2
Body mass index (BMI)	0.3	1.2	7.1	-0.7	0.1	-0.0	-1.9	-0.4	1.4	0.6	-2.7	-1.5	0.2	0.1	-0.5	-0.6	-0.5	-0.6	-1.4	-1.4	0.5
Leg predicted mass (left)	0.3	1.6	6.2	-1.8	-0.2	-0.1	-2.4	-0.5	-0.5	0.1	-2.5	-1.4	-1.0	-0.5	-0.6	-0.9	-1.4	-0.9	-1.8	-1.6	0.4
Trunk fat mass	0.3	1.1	6.2	0.1	1.0	0.7	-1.1	0.4	1.3	1.2	-2.5	-1.0	1.1	0.8	0.2	-1.0	0.5	0.1	-0.9	-0.9	1.2
Waist circumference	0.3	1.0	5.1	0.3	1.1	0.7	-0.6	0.6	1.8	1.3	-2.2	-0.7	1.3	1.0	0.3	-0.4	0.7	0.4	-0.6	-0.3	1.3
Forced vital capacity (FVC)	0.3	1.0	3.1	-0.4	1.3	1.8	0.4	1.0	0.5	1.5	-1.6	-0.2	-0.7	1.3	0.8	-0.8	-0.3	0.2	-0.9	-0.1	1.4
Qualifications: None of the above	0.3	0.6	1.9	-1.0	-0.5	-0.5	-0.0	-0.4	-0.3	-0.6	-0.6	-0.8	-0.8	-0.6	-1.3	1.1	-0.9	-1.4	-0.3	-1.3	-0.5
Financial difficulties in last 2 years	0.3	0.4	1.0	-0.3	-0.6	-0.5	0.3	-0.5	0.3	-0.7	1.0	0.3	-0.6	-0.8	-1.0	0.9	-0.3	0.3	0.1	0.7	-0.4
Allergy	0.3	0.7	1.9	-1.3	0.8	1.2	-0.8	1.0	-1.1	1.0	-0.9	0.2	-1.4	1.0	0.1	0.1	-0.9	-0.1	0.2	0.3	1.2
Diabetes (self-reported)	0.3	0.4	2.3	0.3	0.2	0.1	1.5	0.3	-1.5	0.0	0.6	0.4	0.1	-0.0	-0.4	0.5	0.3	0.4	0.9	0.6	0.2
Weight	0.3	1.4	9.1	-0.9	0.7	0.5	-1.9	0.1	0.8	1.0	-3.0	-1.4	0.2	0.5	-0.2	-1.0	-0.4	-0.5	-1.4	-1.4	1.1
Number of live births	0.3	0.4	1.4	0.8	0.9	0.5	0.2	0.5	1.0	0.7	-0.6	-0.1	0.4	0.2	1.1	-0.1	1.2	-0.6	0.5	-0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.2	-1.1	0.1	0.6	-1.1	-0.2	0.5	0.4	-1.8	-1.1	-1.1	0.3	0.1	-1.3	-1.0	-0.3	-1.8	-0.7	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.1	1.0	-0.6	-0.7	0.2	-0.6	0.2	-0.8	0.6	-0.3	1.0	-0.3	0.4	-0.6	0.2	-0.2	-0.2	0.4	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.6	2.1	-0.8	-0.4	-0.4	-0.3	-0.3	-0.6	-0.3	-1.0	-0.9	-1.4	-0.1	-0.6	-0.6	-0.6	-1.2	-0.7	-1.2	-0.3
Asthma	0.3	0.7	3.3	1.2	-0.6	-1.2	0.8	-1.0	0.3	-0.8	0.4	-0.4	1.8	-0.5	0.0	-0.1	1.0	-0.1	-0.3	-0.7	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.3	0.4	-0.5	-1.2	0.1	-1.1	0.5	-0.5	-0.7	-0.9	1.0	-0.7	-0.1	0.5	0.5	-1.0	-0.6	-0.6	-0.9
Impedance of arm (left)	0.3	1.4	5.9	1.8	-0.2	-0.2	1.9	0.3	-0.4	-0.4	2.4	1.3	1.4	0.2	0.9	-0.1	1.5	1.2	1.5	1.2	-0.6
Arm fat mass (right)	0.3	1.3	7.5	-0.8	0.0	-0.2	-1.9	-0.5	1.0	0.4	-2.7	-1.6	0.2	-0.0	-0.6	-1.1	-0.5	-0.6	-1.6	-1.5	0.4
Trunk predicted mass	0.3	1.5	5.6	-2.0	0.5	0.6	-2.0	0.2	-0.8	0.8	-2.4	-0.9	-1.5	0.1	-0.7	-0.8	-1.6	-0.4	-1.5	-1.3	1.1
Breastfed as a baby	0.3	0.4	1.7	0.3	0.7	0.7	0.5	0.3	-0.4	0.7	-0.5	0.1	1.3	0.7	1.0	-0.4	1.2	0.3	-0.1	-0.3	0.6
Tense / ‘highly strung’	0.3	0.5	2.5	1.6	0.3	-0.5	0.6	-0.2	0.6	-0.2	0.1	-0.0	1.3	0.0	1.4	0.2	1.1	-0.4	0.4	0.5	-0.1
Birth weight of first child	0.3	0.6	3.6	-0.1	0.8	0.8	-0.6	0.5	1.9	0.9	-0.9	0.0	0.3	0.5	0.2	-0.9	0.2	0.6	-0.2	-0.5	1.0
Medication: Amlodipine	0.3	0.4	1.3	0.6	-0.1	-0.7	-0.8	-0.7	-0.0	-0.2	-0.8	-0.9	1.1	-0.2	0.3	-0.8	0.5	-0.8	-0.6	-0.4	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.0	3.5	-0.2	1.4	1.9	0.5	1.1	0.9	1.4	-1.2	0.1	-0.5	1.4	0.8	-0.2	0.2	0.6	-0.6	0.2	1.6
Arm fat-free mass (right)	0.3	1.6	8.5	-1.6	0.8	0.9	-2.0	0.3	0.1	1.1	-2.9	-1.2	-1.1	0.4	-0.3	-0.6	-1.1	-0.6	-1.7	-1.4	1.3
Age at first live birth	0.3	0.5	1.2	-0.4	0.4	0.6	1.1	1.0	-0.5	0.7	0.6	0.9	-0.9	0.7	0.3	1.0	0.1	0.5	1.0	-0.1	0.6
Emphysema/chronic bronchitis	0.3	0.3	2.5	0.7	0.1	-0.1	0.6	-0.1	-0.2	0.1	-0.6	-0.4	1.2	-0.2	0.4	1.6	0.7	-0.2	0.2	-0.1	-0.3
Neck or shoulder pain in last month	0.3	0.4	2.6	-0.4	-0.3	-0.2	1.2	-0.1	0.2	-0.5	0.7	0.3	-0.9	-0.2	-1.1	1.6	-0.3	-0.2	0.5	0.3	-0.2
Medication: Seretide 50 evohaler	0.3	0.3	1.5	0.3	-0.3	-0.7	0.5	-0.3	-0.6	-0.2	-0.6	-0.6	1.1	-0.5	-0.2	0.5	-0.1	-0.3	-0.4	-1.2	-0.4
Arm predicted mass (right)	0.3	1.5	8.0	-1.4	1.1	1.2	-1.7	0.6	0.2	1.3	-2.8	-0.9	-0.9	0.6	-0.1	-0.2	-0.9	-0.4	-1.4	-1.3	1.6
Number of full sisters	0.3	0.3	1.4	0.7	0.4	0.3	0.4	0.1	1.2	0.4	-0.6	-0.3	1.1	-0.1	0.8	0.5	0.8	0.4	0.1	0.1	0.2
Whole body fat-free mass	0.3	1.6	6.5	-1.9	0.4	0.5	-2.2	-0.0	-0.6	0.6	-2.5	-1.2	-1.3	-0.0	-0.5	-0.7	-1.4	-0.7	-1.7	-1.4	1.0
Long-standing illness, disability or infirmity	0.3	0.4	1.6	1.3	0.6	-0.2	0.9	0.2	0.8	0.4	0.3	0.4	1.1	0.6	0.5	0.7	0.9	0.0	0.8	-0.1	0.4
Ever had bowel cancer screening	0.3	0.4	1.0	0.5	1.0	0.8	0.3	0.6	-0.2	0.7	-0.8	-0.1	-0.0	0.9	0.5	-0.9	0.3	-0.8	0.1	-0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.4	-0.2	-0.2	-0.0	0.1	-0.5	0.1	-0.8	-0.6	-0.9	-0.2	0.3	0.4	-0.6	-0.9	-0.7	-0.9	-0.0
Asthma (self-reported)	0.3	0.7	2.6	1.2	-0.6	-1.2	0.9	-1.0	-0.0	-0.9	0.6	-0.3	1.6	-0.6	-0.1	0.1	0.9	-0.4	-0.1	-0.8	-1.0
Smoking status: Current	0.3	0.4	1.8	1.0	0.5	0.1	0.9	0.4	-0.3	0.3	0.9	0.8	0.4	0.1	0.4	0.4	0.5	0.5	1.3	0.8	0.3
Whole body water mass	0.3	1.6	6.7	-1.9	0.3	0.3	-2.2	-0.1	-0.6	0.6	-2.6	-1.3	-1.2	-0.1	-0.6	-0.7	-1.5	-0.7	-1.8	-1.5	0.9
Arm fat mass (left)	0.3	1.1	6.8	-0.6	0.3	0.1	-1.7	-0.2	1.2	0.6	-2.6	-1.4	0.5	0.2	-0.3	-0.9	-0.4	-0.2	-1.3	-1.2	0.6
Financial situation satisfaction	0.3	0.4	3.0	-0.1	-0.2	-0.0	0.7	-0.1	-0.2	0.0	0.8	0.7	-1.3	0.0	-0.2	1.7	-0.9	0.0	0.2	0.1	0.1
High cholesterol (Self-reported)	0.3	0.5	1.5	0.5	0.0	-0.4	0.4	-0.3	1.2	0.2	-1.0	-0.7	1.1	-0.3	0.2	0.1	1.0	-1.2	-0.2	-1.2	-0.3
Medication: Paracetamol	0.3	0.5	2.8	0.3	-0.7	-0.9	1.3	-0.2	0.9	-0.5	0.6	-0.0	0.2	-0.3	-0.7	1.7	0.6	-0.6	0.5	0.1	-0.6
Basal metabolic rate	0.3	1.4	7.0	-1.6	0.5	0.5	-2.1	0.1	-0.1	0.8	-2.6	-1.2	-0.9	0.1	-0.4	-0.8	-1.1	-0.5	-1.6	-1.4	1.0
Leg fat percentage (left)	0.3	1.2	4.3	0.8	1.4	1.1	-0.4	0.7	1.6	1.6	-2.1	-0.5	1.5	1.2	0.4	-0.2	0.6	0.6	-0.2	-0.1	1.5
Average weekly beer plus cider intake	0.3	0.5	2.4	0.2	-0.4	-0.8	0.3	-0.7	0.0	-0.6	-0.7	-0.9	1.6	-0.3	0.2	-0.2	1.3	-0.5	-0.3	-0.6	-0.6
Risk taking	0.3	0.5	1.9	-0.7	-0.6	-0.7	-1.4	-0.8	0.0	-0.4	-1.0	-0.7	0.1	-0.5	0.4	-0.0	0.4	-0.7	-0.6	-1.3	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.1	-1.8	-0.8	0.1	-0.3	-0.4	-0.0	-0.7	0.2	-0.3	-1.2	-1.1	-1.3	-0.4	-1.7	0.5	-0.9	-0.3	-0.7
Leg fat mass (left)	0.3	1.0	6.9	-0.1	1.1	0.8	-1.2	0.4	1.0	1.3	-2.6	-1.0	0.7	0.8	-0.0	-0.5	0.1	0.0	-0.9	-0.7	1.3
Arm predicted mass (left)	0.3	1.6	7.7	-1.7	0.7	0.7	-1.9	0.1	-0.1	0.9	-2.8	-1.2	-1.1	0.3	-0.5	-0.6	-1.4	-0.7	-1.7	-1.4	1.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	0.6	0.9	0.7	0.8	0.3	1.2	0.8	-0.9	0.1	0.9	0.4	1.1	0.4	0.5	0.5	0.1	0.4	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.0	0.0	1.2	1.4	0.6	1.2	-0.1	1.3	-1.0	-0.0	0.8	1.2	0.8	-1.0	1.0	0.3	-0.3	-0.1	1.0
Neuroticism (Nagel 2018)	0.2	0.5	2.1	1.0	0.6	0.2	1.2	0.1	0.8	0.4	-0.5	0.0	0.9	0.2	1.0	1.4	1.0	0.1	0.5	0.7	0.3
Crohns Disease (2017)	0.2	0.4	0.9	0.1	0.7	0.7	-0.5	0.9	0.9	0.7	0.2	0.7	0.1	0.8	0.5	0.5	-0.0	0.9	0.5	0.2	1.0
Crohns Disease (2012)	0.2	0.2	1.0	-0.8	-0.5	0.0	-1.0	-0.3	-0.4	-0.4	0.2	-0.0	-0.9	-0.3	-1.0	-0.4	-0.2	0.0	0.0	0.0	0.0
BMI	0.2	1.3	6.1	-1.4	0.2	0.4	-1.9	0.1	1.3	0.8	-2.5	-1.1	-0.8	0.5	-0.6	-1.1	-0.7	-0.6	-1.4	-1.4	0.8
Height	0.2	3.3	13.3	-0.6	1.9	1.5	-1.4	1.4	-1.0	2.0	-3.6	-1.4	1.2	1.6	1.3	-3.6	0.9	-0.7	-1.4	-2.3	1.7
Medication: Metformin	0.2	0.3	2.8	0.1	0.2	-0.0	0.7	0.3	-1.7	-0.1	0.3	0.2	-0.2	0.1	-0.0	0.6	0.4	-0.1	0.3	0.9	0.1
Severe depression (siblings)	0.2	0.3	2.2	-0.8	-0.6	-0.1	0.4	-0.4	0.0	-0.5	-0.0	-0.3	-0.3	-0.3	-1.5	-0.2	-0.5	0.2	-0.1	-0.1	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	1.0	0.0	0.6	0.5	-0.5	0.6	-0.4	0.5	-0.9	-0.1	0.4	0.5	1.0	-0.7	0.4	0.1	-0.0	-0.7	0.7
Nervous feelings	0.2	0.4	1.8	1.3	0.4	-0.5	0.5	0.0	0.0	-0.0	0.6	0.4	0.6	0.4	0.7	0.5	0.6	0.0	0.6	1.3	0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.5	0.1	0.2	-0.1	0.4	-0.8	0.3	0.7	0.6	0.0	0.7	0.2	0.8	-0.3	0.6	0.8	0.7	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.7	0.8	0.8	0.2	-0.7	0.5	0.9	0.7	-0.6	0.0	1.3	0.6	1.1	-0.3	0.4	0.2	0.2	-0.2	0.6
Pain all over the body in last month	0.2	0.2	1.3	0.2	0.5	-0.1	-0.2	0.1	0.9	0.4	-0.3	0.0	0.2	0.5	-0.0	-0.1	0.4	0.7	0.0	1.1	0.5
Medication: Simvastatin	0.2	0.3	2.0	0.8	-0.0	-0.3	0.5	-0.3	0.2	0.0	-0.1	-0.2	1.4	-0.2	0.2	1.1	0.8	-0.5	0.2	0.1	-0.3
Impedance of arm (right)	0.2	1.0	4.9	1.3	-0.5	-0.6	1.5	-0.0	-0.7	-0.7	2.2	0.9	1.1	-0.2	0.7	-0.5	1.4	0.7	1.2	0.8	-0.8
Arm fat percentage (right)	0.2	0.9	4.7	-0.2	-0.0	-0.4	-1.6	-0.5	1.2	0.3	-2.2	-1.3	0.9	-0.1	-0.3	-1.0	-0.1	-0.2	-1.1	-1.1	0.2
Trunk fat-free mass	0.2	1.4	5.1	-1.9	0.6	0.8	-1.9	0.3	-0.7	0.9	-2.3	-0.8	-1.3	0.3	-0.5	-0.8	-1.4	-0.3	-1.3	-1.2	1.2
Falls in the last year	0.2	0.3	1.6	0.3	0.2	0.1	-0.1	0.1	1.1	0.4	0.3	0.2	0.7	0.0	-0.8	-0.7	-0.0	1.3	0.5	0.4	0.3
Happiness	0.2	0.2	1.6	0.3	0.3	0.0	0.4	0.0	1.3	0.3	-0.3	-0.1	-0.1	0.3	-0.1	1.2	0.6	-0.5	0.1	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.1	-0.8	0.8	1.2	-0.5	0.4	1.2	0.8	-1.4	-0.4	-0.9	0.9	0.3	-0.5	-0.4	0.5	-1.1	-0.2	1.0
Length of working week for main job	0.2	0.2	0.7	-0.1	-0.2	-0.3	-0.5	0.3	-0.1	0.0	-0.3	-0.2	-0.8	0.1	0.5	0.6	-0.3	-0.7	-0.5	-0.8	0.1
Peak expiratory flow (PEF)	0.2	0.5	3.2	-1.2	-0.3	0.1	-0.8	-0.3	0.3	-0.1	-0.3	-0.4	-1.8	-0.2	-0.6	-0.0	-1.3	-0.6	-1.2	-0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.4	0.3	0.9	-0.4	0.6	-0.5	0.2	0.6	0.6	-0.5	0.1	-0.1	-0.2	-0.6	0.9	0.5	0.7	0.5
Glaucoma (self-reported)	0.2	0.2	0.9	0.0	0.1	-0.0	-0.7	0.4	-0.9	0.2	-0.2	-0.1	0.4	0.2	0.3	-0.5	0.9	-0.2	0.1	-0.8	-0.1
Gout (self-reported)	0.2	0.2	1.0	0.2	-0.3	-0.6	0.2	-0.2	0.9	-0.1	-0.2	-0.2	1.0	-0.3	-0.3	0.6	0.0	0.4	-0.1	-0.8	-0.1
Body fat percentage	0.2	1.0	4.4	0.6	1.0	0.6	-0.6	0.4	1.7	1.2	-2.1	-0.8	1.6	0.9	0.3	-0.5	0.6	0.5	-0.5	-0.6	1.0
Leg fat percentage (right)	0.2	0.9	2.8	0.7	1.2	0.9	-0.3	0.7	1.4	1.4	-1.7	-0.3	1.3	1.0	0.3	0.1	0.4	0.7	0.1	-0.1	1.3
Medication: Blood pressure	0.2	0.4	1.2	0.1	-0.4	-1.0	-0.5	-0.4	-0.6	-0.2	-0.6	-0.5	0.2	-0.2	0.3	-0.9	0.8	-1.1	-0.2	-0.8	-0.5
Medication: Allopurinol	0.2	0.2	0.9	0.3	0.1	-0.4	-0.7	0.1	1.0	0.2	-0.0	0.1	0.6	0.0	0.1	0.9	0.6	0.1	-0.0	-0.4	0.3
Heart disease (mother)	0.2	0.2	1.3	-0.1	-0.3	0.1	-1.1	-0.4	0.2	-0.2	-0.7	-0.7	0.4	-0.4	-0.3	0.3	-0.4	0.1	-0.9	-0.3	-0.4
Whole body fat mass	0.2	1.0	6.2	-0.2	0.7	0.5	-1.3	0.2	1.2	1.0	-2.5	-1.1	0.8	0.6	-0.1	-0.8	0.1	-0.0	-1.0	-1.0	1.0
Leg fat mass (right)	0.2	1.0	6.9	-0.3	0.9	0.6	-1.3	0.3	1.0	1.1	-2.6	-1.1	0.6	0.6	-0.1	-0.6	-0.2	-0.0	-0.9	-0.9	1.1
Suffer from ‘nerves’	0.2	0.4	1.2	0.1	-0.3	-1.1	-0.2	-0.7	0.0	-0.5	-0.9	-1.0	0.2	-0.3	-0.3	0.6	-0.6	-1.1	-0.5	-0.2	-0.6
Overall health rating	0.2	0.4	0.9	0.6	-0.4	-1.0	-0.1	-0.9	-0.3	-0.6	-0.6	-0.9	0.7	-0.4	0.1	0.9	-0.4	-0.8	-0.4	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-0.8	-0.5	-0.6	0.9	0.0	0.1	-0.4	0.1	-0.0	-0.4	-0.1	-1.1	0.7	-0.4	-0.2	0.6	0.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	0.6	0.2	0.2	0.3	0.1	0.7	0.1	0.6	0.6	0.5	0.4	0.8	0.6	0.6	0.3	0.2	0.8	0.1
Supplements: Vitamin C	0.2	0.2	0.5	-0.3	-0.6	-0.4	-0.4	-0.6	-0.0	-0.6	-0.0	-0.4	0.2	-0.3	0.2	0.0	0.6	-0.3	-0.1	0.7	-0.7
Arm fat percentage (left)	0.2	0.7	3.4	0.2	0.2	-0.1	-1.3	-0.3	1.5	0.5	-1.9	-1.0	1.2	0.2	0.0	-0.6	0.1	0.3	-0.7	-0.7	0.4
Friendships satisfaction	0.2	0.2	0.9	-0.3	-0.4	-0.2	0.9	-0.0	-0.6	-0.5	0.0	-0.2	-0.6	-0.3	-0.5	0.4	0.0	-0.9	0.0	-0.3	-0.6
Commuting to job workplace: Walk	0.2	0.2	1.2	-0.5	0.1	-0.1	-0.2	-0.2	-0.7	-0.0	-0.1	-0.2	-0.4	-0.3	-0.8	-1.1	-0.3	0.3	-0.1	-0.1	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.8	-0.6	0.1	0.5	-0.0	0.1	-1.4	0.1	-0.2	-0.1	-0.4	0.1	0.2	-0.7	-0.9	0.4	-0.0	0.4	0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.3	0.1	-0.7	-1.0	-0.2	-1.1	0.9	-0.9	-0.5	-1.0	0.6	-0.7	-0.6	0.0	-0.3	-1.0	-1.1	-0.6	-1.0
Commuting to job workplace: Cycle	0.2	0.2	1.0	-0.4	0.2	0.4	-0.3	0.2	-1.0	0.1	0.3	0.3	-0.4	-0.3	-0.7	-0.1	-0.9	0.3	-0.1	-0.3	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	1.2	0.2	-0.1	0.0	0.0	0.1	0.2	-0.2	1.1	0.5	0.4	0.0	-0.0	-1.0	-0.3	0.9	0.2	0.8	-0.2
Alcohol drinker status: Previous	0.2	0.2	1.1	0.7	0.0	-0.3	1.0	0.2	-0.5	0.1	-0.0	-0.1	0.5	0.0	0.4	-1.0	0.5	0.1	0.6	-0.3	0.0
Depression (Nagel 2018)	0.1	0.2	1.0	0.1	0.6	0.2	-0.3	0.1	0.9	0.5	-1.0	-0.3	0.1	0.0	0.4	0.7	-0.2	0.4	-0.3	0.4	0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	2.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.6	0.0	0.0	0.0	0.0
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	-0.7	-0.6	-0.6	-1.1	-0.4	-0.3	-0.5	0.3	-0.0	-0.4	-0.1	-0.3	0.5	-1.0	0.0	-0.3	-0.1	-0.4
Heel T-Score	0.1	0.8	5.5	-1.1	-0.5	-0.1	-1.6	-0.2	2.3	0.0	-0.8	-0.5	-0.5	-0.3	-0.8	-0.6	-0.8	-0.6	-0.6	-1.2	-0.1
Hair Pigment	0.1	2.8	6.2	1.6	1.6	1.7	2.5	1.7	1.4	1.9	1.2	1.9	-0.4	1.8	0.8	2.3	0.6	1.4	1.8	2.0	1.9
Tanning	0.1	1.8	4.6	-0.8	-1.0	-1.4	-0.1	-1.5	-1.0	-1.4	-1.0	-1.6	-0.6	-0.9	-1.3	-1.3	-1.3	-2.1	-1.2	-2.1	-1.6
Average weekly spirits intake	0.1	0.2	0.6	0.6	0.5	0.3	0.7	-0.0	0.0	0.3	-0.8	-0.4	0.5	-0.0	-0.1	0.3	0.1	-0.4	-0.0	0.2	0.2
Townsend deprivation index at recruitment	0.1	0.2	0.6	0.7	0.3	0.1	-0.0	-0.1	-0.4	-0.1	0.1	-0.0	0.6	-0.3	0.3	-0.6	0.8	0.4	0.2	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.8	0.6	0.3	-0.3	-0.7	-0.1	1.3	0.2	-0.2	-0.0	0.9	-0.0	0.5	-0.2	0.1	0.0	0.1	0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.4	0.4	0.4	0.1	0.8	0.1	0.6	0.1	0.5	0.5	-0.5	-0.0	0.1	1.2	-0.2	0.3	0.5	0.5	0.4
Hip circumference	0.1	0.5	2.1	0.5	0.8	0.7	-0.2	0.6	1.4	1.1	-0.8	0.1	0.7	0.9	0.3	0.7	0.1	0.6	0.1	-0.0	1.2
Standing height	0.1	0.9	2.0	-0.5	1.4	1.4	-0.0	1.2	-1.0	1.3	-1.3	-0.0	-0.1	1.0	0.7	-1.3	0.2	0.2	-0.4	-0.4	1.4
Qualifications: College or University degree	0.1	0.4	3.5	-0.9	-0.4	0.1	0.3	-0.4	-0.1	-0.4	0.2	-0.1	-0.9	-0.7	-0.3	-1.9	-0.3	0.2	-0.7	-0.5	-0.4
Comparative height size at age 10	0.1	0.6	1.5	-0.2	1.2	1.1	0.9	1.0	-1.0	0.9	-0.2	0.5	-0.0	0.8	0.4	-0.8	0.1	0.6	0.2	-0.6	1.2
Hypertension (Self-reported)	0.1	0.4	2.1	1.3	0.4	-0.5	-0.1	-0.1	0.4	0.3	-0.3	-0.0	1.0	0.7	0.8	-0.1	1.4	-0.5	0.4	0.4	0.2
Average weekly red wine intake	0.1	0.2	0.8	0.8	0.5	0.1	-0.3	-0.2	-0.1	-0.0	0.6	0.4	0.9	-0.1	-0.2	-0.2	0.3	0.5	0.3	0.5	0.2
Diabetes diagnosed by doctor	0.1	0.2	1.3	0.3	0.5	0.4	1.1	0.5	-0.9	0.4	-0.3	-0.1	0.5	0.1	-0.0	0.1	0.3	0.5	0.4	0.2	0.3
Medication: Gliclazide	0.1	0.1	0.6	-0.3	0.1	0.2	0.5	0.2	-0.8	-0.0	0.0	0.0	-0.6	-0.1	-0.7	-0.1	0.0	-0.3	-0.0	-0.4	-0.0
Guilty feelings	0.1	0.2	0.8	0.4	0.3	0.3	0.4	0.4	-0.0	0.2	0.2	0.5	-0.4	0.1	-0.1	0.8	0.1	-0.3	0.5	0.9	0.4
Medication: Bendroflumethiazide	0.1	0.2	0.8	0.1	0.3	-0.0	-0.9	0.5	-0.4	0.3	0.1	0.4	-0.1	0.7	0.4	-0.8	0.5	-0.0	0.2	0.1	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Myopia	0.0	0.1	0.2	0.4	0.3	-0.1	0.0	0.0	0.3	0.1	-0.5	-0.2	0.1	0.1	0.5	-0.3	-0.1	-0.1	-0.3	-0.1	0.1

Hub : Genes

LRRC56

Models

Trait associations