Hub : Genes

LSM10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0800 0.0330 3.0e-04 -0.002 0.021 0.004 0.017 0.000 8.1e-01 1.1e-03 8.5e-02 3.5e-03 3.4e-01
2 GTEx Muscle Skeletal 0.0748 0.0328 6.9e-03 -0.003 NA -0.002 NA -0.003 8.2e-01 NA 7.4e-01 NA 7.8e-01
3 ROSMAP Brain Pre-frontal Cortex 0.1172 0.0346 6.0e-07 0.156 0.064 0.153 0.155 0.160 1.5e-19 1.2e-08 3.4e-19 1.9e-19 4.3e-20
4 TCGA Liver Hepatocellular Carcinoma 0.0890 0.0600 7.2e-03 0.084 0.032 0.027 NA 0.052 8.7e-05 1.2e-02 2.0e-02 NA 1.8e-03
5 TCGA Thyroid Carcinoma 0.0710 0.0390 1.0e-03 0.046 0.045 0.041 NA 0.042 2.7e-05 3.4e-05 6.3e-05 NA 5.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.8 0.7 0.0 0.6 0.9 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.8 1.9 -1.1 0.0 0.7 1.4 0.4
Depressed Affect (Nagel 2018) 0.5 1.1 2.3 -1.1 0.0 -1.4 1.5 0.4
Depression (Nagel 2018) 1.3 1.9 6.9 -0.2 0.0 -2.6 0.7 -1.5
Intelligence (Savage-Jansen 2018) 0.4 1.3 3.4 -0.9 0.0 0.5 -1.5 -1.9
Neuroticism (Nagel 2018) 0.5 1.1 3.0 -1.1 0.0 -1.7 1.0 0.4
Schizophrenia (2018) 0.5 1.1 3.5 -1.9 0.0 0.5 1.1 0.8
Schizophrenia vs Biploar Disorder 0.6 0.8 1.7 -0.4 0.0 -1.3 1.1 -1.1
Worry (Nagel 2018) 0.1 0.3 1.0 -0.6 0.0 -1.0 0.0 -0.1
Alzheimer’s Disease (in mother) 0.6 0.7 1.3 -0.9 0.0 -1.1 -1.1 -0.3
Alzheimer’s Disease (in father) 0.2 0.2 1.0 -0.0 0.0 0.2 -1.0 0.2
Alzheimer’s Disease (including proxy) 0.4 0.5 1.3 -0.4 0.0 -0.9 -1.1 -0.7
Crohns Disease (2017) 0.6 1.3 3.4 0.8 0.0 1.6 1.9 0.4
Irritable Bowel Disease (IBD) 0.5 1.1 4.7 -0.3 0.0 0.9 2.2 0.2
Ulcerative Colitis (UC) 0.2 0.4 2.0 -0.3 0.0 -0.2 1.4 0.0
Major Depression (MDD) 1.3 1.6 4.0 -0.3 0.0 2.0 -1.1 1.6
Reaction Time 0.2 0.5 1.3 1.1 0.0 0.7 -0.1 0.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.7 0.6 0.0 0.4 -1.2 -1.6
Breast Cancer 0.7 1.6 4.5 -1.3 0.0 -0.9 -1.0 -2.1
Ovarian Cancer 0.6 0.7 1.8 0.5 0.0 1.3 0.7 1.1
Prostate Cancer 0.3 0.5 1.7 -0.3 0.0 1.3 -0.5 0.5
Age at First Birth 0.5 0.7 3.0 1.7 0.0 0.1 0.6 -0.3
Bipolar Disorder (2011) 0.6 0.6 2.5 0.1 0.0 0.6 -0.3 1.6
Body Mass Index (BMI) (2010) 1.4 2.0 3.7 -0.9 0.0 1.8 1.5 1.9
Coronary Artery Disease (CAD) 0.2 0.3 0.8 0.2 0.0 0.4 0.9 0.7
Crohns Disease (2012) 0.6 1.0 2.9 1.3 0.0 0.6 1.7 0.1
Mean Putamen Volume 0.5 0.6 2.6 -0.3 0.0 0.3 -1.6 0.3
Fasting Glucose 0.7 0.8 2.9 -1.7 0.0 -0.5 -0.7 0.6
HbA1C 0.2 0.2 0.8 -0.3 0.0 0.4 -0.4 0.9
HDL Cholesterol 0.7 1.1 4.2 -0.3 0.0 0.7 -2.1 -0.9
LDL Cholesterol 0.6 0.9 3.5 0.6 0.0 -0.9 1.9 0.1
Lupus 0.2 0.2 0.5 0.6 0.0 0.1 0.7 0.7
Neuroticism (2016) 0.3 0.4 1.3 -0.7 0.0 -1.1 0.5 -0.3
Primary Biliary Cirrhosis 0.3 0.4 1.2 -0.0 0.0 -0.4 0.8 1.1
Rheumatoid Arthritis 1.0 1.3 4.7 2.2 0.0 0.1 -1.1 0.7
Schizophrenia (2014) 0.6 1.3 3.2 -1.8 0.0 0.1 1.6 0.7
Triglycerides 1.1 1.9 5.7 0.4 0.0 -0.3 2.4 1.8
Type 2 Diabetes (T2D) (2012) 0.8 0.9 4.0 -0.2 0.0 0.2 0.7 2.0
Ulcerative Colitis 0.5 0.8 1.9 -0.5 0.0 -1.4 1.3 -0.1
Blood Eosinophil Count 0.4 2.7 8.8 -3.0 0.0 -1.3 -1.7 0.6
Blood Platelet Count 0.6 7.5 28.1 5.3 0.0 1.9 2.0 -1.4
Blood Red Count 0.2 1.6 6.1 -2.5 0.0 -0.8 -0.1 1.1
Blood White Count 2.0 15.1 54.2 0.9 0.0 1.5 4.3 7.4
Heel T-Score 0.1 0.9 2.7 0.2 0.0 0.1 1.6 1.3
BMI 0.1 0.5 1.5 -1.2 0.0 -0.9 0.6 -0.1
Height 0.1 2.6 5.8 -2.3 0.0 -2.4 1.3 -0.0
Waist Hip Ratio (WHR) 0.6 2.8 10.7 3.3 0.0 1.3 -0.7 -1.1
Systolic Blood Pressure 0.1 0.4 1.2 1.1 0.0 0.2 -0.8 -0.4
Smoking Status 0.2 0.5 1.9 0.1 0.0 -1.4 -0.3 -0.7
Allergy or Eczema 0.5 1.4 4.4 -2.1 0.0 -1.6 -0.4 0.1
Cardiovascular Disease 0.3 0.9 2.4 -1.1 0.0 -1.5 0.1 -1.0
Hypothyroidism (self reported) 0.1 0.2 0.5 0.7 0.0 -0.4 0.1 -0.5
Respiratory disease 0.1 0.2 0.6 -0.5 0.0 -0.8 0.4 -0.0
Type 2 Diabetes (T2D) (2018) 1.3 2.4 7.9 -1.9 0.0 0.2 0.6 2.8
Lung FEV1/FVC ratio 0.4 2.0 6.4 1.3 0.0 0.6 2.5 1.3
Lung FVC 0.1 0.3 1.4 -0.4 0.0 0.3 -0.2 1.2
Neuroticism 0.6 1.4 5.5 -1.1 0.0 -2.4 0.5 -0.5
Chronotype (morning person) 0.7 1.7 4.2 2.0 0.0 -0.1 1.5 1.3
Hair Pigment 0.0 0.4 1.0 -0.8 0.0 0.0 0.8 1.0
Tanning 0.0 0.4 1.6 0.1 0.0 0.1 -1.3 -0.7
Hand grip strength (left) 0.7 1.7 4.1 -2.0 0.0 -1.1 0.7 -1.7
Number of treatments/medications taken 0.0 0.0 0.1 0.3 0.0 -0.1 0.2 -0.2
Average weekly spirits intake 0.9 1.1 2.0 -1.3 0.0 -1.3 1.4 -0.0
Sensitivity / hurt feelings 1.0 1.8 4.1 1.2 0.0 -1.8 2.0 0.4
Frequency of depressed mood in last 2 weeks 0.9 1.2 4.5 -0.2 0.0 -2.1 0.7 -1.0
Hearing difficulty/problems: Yes 0.4 0.6 1.2 0.6 0.0 0.5 -1.1 1.0
Relative age of first facial hair 0.2 0.5 1.6 -0.1 0.0 0.8 1.2 0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.5 -1.2 0.0 -0.6 0.0 0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.1 2.7 0.3 0.0 -1.6 -1.4 -0.7
Ever had hysterectomy (womb removed) 0.2 0.3 0.5 0.2 0.0 -0.6 -0.7 -0.6
Systolic blood pressure, automated reading 0.1 0.4 0.7 0.9 0.0 0.7 -0.4 0.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.3 1.8 0.0 0.8 0.4 0.7
Angina 0.8 1.1 3.0 -0.6 0.0 -0.6 -1.7 -1.3
Medication for hormone replacement therapy 0.6 0.6 1.6 0.9 0.0 1.3 -0.6 0.5
Vitamin and mineral supplements 1.6 2.2 8.2 -1.6 0.0 0.0 -2.9 -0.6
Supplements: Zinc 0.5 0.6 2.2 0.6 0.0 -1.5 0.2 -0.3
Medication: Co-codamol 0.7 0.8 3.0 -0.9 0.0 -0.5 0.3 1.7
Medication: Metformin 0.8 1.1 2.8 -0.8 0.0 0.9 1.2 1.7
Diabetes (father) 0.4 0.5 1.8 -0.1 0.0 1.4 0.4 0.7
Diabetes (mother) 1.6 2.0 5.0 1.9 0.0 2.2 0.6 1.1
Severe depression (siblings) 1.1 1.2 3.5 0.1 0.0 -0.8 -1.4 -1.9
Pack years adult smoking proportion 0.7 1.0 2.1 1.4 0.0 -0.7 -0.8 -1.4
Impedance of leg (right) 0.7 3.5 14.8 3.9 0.0 1.4 -0.3 -0.6
Leg fat-free mass (left) 0.4 2.3 8.2 -2.9 0.0 -1.7 -0.2 -0.2
Trunk fat percentage 0.3 1.0 4.0 1.0 0.0 -0.4 -2.0 -0.2
Hand grip strength (right) 1.1 3.0 13.5 -3.7 0.0 -0.4 0.0 -1.2
Townsend deprivation index at recruitment 0.8 1.2 2.2 1.3 0.0 1.5 -0.5 1.3
Current tobacco smoking 0.3 0.5 2.2 1.5 0.0 -0.2 -0.1 0.3
Average weekly fortified wine intake 0.2 0.2 0.7 -0.2 0.0 -0.3 -0.8 0.3
Maternal smoking around birth 1.7 2.5 5.4 2.3 0.0 0.8 -2.3 -1.0
Fed-up feelings 0.4 0.7 1.8 0.4 0.0 -1.3 1.1 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.2 10.0 -0.6 0.0 -3.2 0.7 -0.7
Relative age voice broke 0.7 1.1 2.7 0.0 0.0 1.6 -1.6 -0.4
Taking other prescription medications 0.5 0.8 1.7 -1.1 0.0 -1.3 -0.7 0.7
Age when periods started (menarche) 0.6 1.4 3.6 -0.3 0.0 1.5 -1.1 1.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 0.6 0.0 1.0 -0.3 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.4 -0.6 0.0 0.3 -0.2 0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 2.2 -1.5 0.0 1.0 0.0 -0.8
Qualifications: CSEs or equivalent 0.4 0.5 1.5 -0.6 0.0 -0.7 -1.2 -0.4
Serious illness, injury or assault to yourself 0.9 1.1 3.0 1.3 0.0 -0.1 -1.7 -1.0
High blood pressure 0.0 0.1 0.4 0.1 0.0 -0.0 -0.6 0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.0 -1.4 0.0 -0.9 0.1 0.2
Multivitamins +/- minerals 1.0 1.3 5.4 0.8 0.0 -0.7 2.3 0.4
Stomach or abdominal pain in last month 0.6 0.8 2.2 0.9 0.0 -0.9 -0.4 -1.5
Supplements: Glucosamine 0.1 0.1 0.4 0.1 0.0 0.1 0.6 0.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.1 -0.2 0.0 0.2 0.9 1.1
Medication: Atenolol 1.5 1.8 5.7 -0.8 0.0 -1.6 0.4 -2.4
Medication: Levothyroxine sodium 0.2 0.3 0.9 0.6 0.0 -0.9 -0.4 0.2
Sitting height 0.4 3.1 5.5 -2.0 0.0 -2.4 0.9 -2.2
Chronic bronchitis/emphysema (father) 0.8 1.0 2.1 1.4 0.0 -0.9 -0.8 -1.1
High blood pressure (mother) 0.7 0.9 2.4 -1.2 0.0 1.6 -0.6 0.6
Body mass index (BMI) 0.2 0.8 1.4 -0.9 0.0 -1.2 -1.1 0.5
Impedance of leg (left) 0.5 2.6 10.7 3.3 0.0 1.3 0.0 -0.8
Leg predicted mass (left) 0.4 2.3 8.4 -2.9 0.0 -1.8 -0.2 -0.3
Trunk fat mass 0.1 0.5 1.9 0.0 0.0 -0.8 -1.4 -0.2
Waist circumference 0.0 0.1 0.3 0.4 0.0 -0.6 -0.4 0.0
Number of incorrect matches in round 1.4 2.2 6.9 2.6 0.0 0.0 1.4 -1.6
Past tobacco smoking 0.6 1.2 2.9 1.7 0.0 1.5 -0.2 0.8
Alcohol usually taken with meals 0.1 0.2 0.4 -0.6 0.0 -0.5 0.5 -0.1
Nervous feelings 0.1 0.2 0.7 -0.5 0.0 -0.8 0.5 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.2 -1.0 0.0 -1.5 -1.5 -0.4
Hearing difficulty/problems with background noise 0.4 0.7 2.7 1.6 0.0 0.1 -0.6 -0.5
Hair/balding pattern: Pattern 2 0.1 0.1 0.5 0.7 0.0 -0.4 0.1 -0.3
Had menopause 0.9 1.1 5.0 -0.1 0.0 0.7 0.0 2.2
Had other major operations 1.0 1.2 2.9 1.7 0.0 0.9 -0.4 1.4
Forced vital capacity (FVC) 0.1 0.4 1.0 -0.7 0.0 -1.0 0.5 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.4 -0.1 0.0 0.4 0.7 0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.5 0.9 0.0 0.2 -1.2 -0.7
Qualifications: None of the above 0.5 1.1 3.1 1.8 0.0 -0.3 1.5 0.3
Financial difficulties in last 2 years 0.2 0.3 0.6 0.5 0.0 0.8 -0.3 0.6
Mouth/teeth dental problems 0.8 1.3 4.9 -2.2 0.0 -0.7 -0.0 1.0
Heart attack 0.5 0.6 2.2 -0.6 0.0 0.2 -0.7 -1.5
Allergy 0.1 0.1 0.2 0.4 0.0 0.4 0.2 -0.5
Pain all over the body in last month 0.1 0.1 0.3 -0.5 0.0 -0.4 -0.5 0.2
Diabetes (self-reported) 0.5 0.7 1.7 -0.0 0.0 1.0 0.9 1.3
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 3.6 -0.7 0.0 -0.5 -1.9 -0.5
Medication: Ramipril 0.7 0.8 2.5 0.4 0.0 1.6 -1.1 -0.6
Medication: Simvastatin 0.3 0.4 1.0 0.4 0.0 -0.4 1.0 -0.9
Fluid intelligence score 0.4 0.8 1.8 0.7 0.0 0.8 -0.9 -1.3
Illnesses of siblings 0.5 0.7 1.2 0.9 0.0 -1.0 0.4 1.1
Neuroticism score 1.0 2.1 7.0 -1.4 0.0 -2.7 1.2 -0.3
Weight 0.3 1.3 3.4 -1.8 0.0 -1.8 -0.5 -0.1
Impedance of arm (right) 0.5 2.2 7.3 2.7 0.0 1.5 -1.2 -0.3
Arm fat percentage (right) 0.2 1.0 3.8 0.3 0.0 -0.9 -1.9 0.4
Trunk fat-free mass 0.7 4.3 14.7 -3.8 0.0 -2.3 1.2 -0.3
Hip circumference 0.3 1.2 4.5 -1.1 0.0 -2.1 -0.6 -0.0
Time employed in main current job 0.2 0.2 0.6 -0.8 0.0 -0.0 -0.4 0.4
Alcohol intake versus 10 years previously 0.5 0.8 1.8 0.4 0.0 0.4 1.3 1.3
Father’s age at death 0.1 0.2 0.5 0.7 0.0 -0.0 -0.4 -0.3
Worrier / anxious feelings 0.4 0.7 1.7 -0.5 0.0 -1.3 1.1 -0.7
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 6.3 -1.3 0.0 -2.5 -1.3 -1.4
Falls in the last year 0.2 0.3 1.4 -0.2 0.0 0.1 -1.2 0.4
Hair/balding pattern: Pattern 3 0.2 0.4 1.4 -0.5 0.0 0.2 0.3 1.2
Number of live births 0.4 0.6 1.1 -0.7 0.0 0.5 1.0 1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.3 -0.5 0.0 -1.5 0.8 -0.5
Pulse rate 0.2 0.3 1.3 -1.1 0.0 -0.5 -0.2 0.3
Happiness 0.7 0.9 2.0 1.4 0.0 -1.0 1.0 -0.6
Noisy workplace 0.9 1.1 4.7 -2.2 0.0 -0.8 0.1 -0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.1 -1.4 0.0 -0.8 0.3 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.1 -1.5 0.0 -0.3 0.4 -1.1
Mouth/teeth dental problems: Dentures 0.4 0.6 1.9 1.4 0.0 -0.1 -0.4 -1.1
Asthma 0.4 0.7 3.1 0.1 0.0 0.8 -0.1 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.2 0.0 -0.4 0.4 0.5
Medication: Cholesterol lowering 0.1 0.2 0.5 0.2 0.0 0.5 0.2 -0.7
Depression (self-reported) 0.4 0.5 2.3 -0.2 0.0 -0.0 -1.5 -0.2
Medication: Lansoprazole 0.6 0.7 1.5 0.4 0.0 1.2 0.6 1.2
Prospective memory result 0.7 0.8 1.9 -1.4 0.0 1.2 -0.6 0.6
Lung cancer (father) 0.5 0.6 2.4 0.4 0.0 1.6 0.5 -0.3
Illnesses of mother 1.6 2.0 8.0 2.8 0.0 0.1 1.2 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.9 -1.3 0.0 -1.7 0.8 -0.6
Pulse wave Arterial Stiffness index 0.7 0.8 3.7 0.2 0.0 -1.9 -0.3 -0.6
Impedance of arm (left) 0.4 1.7 6.1 2.5 0.0 1.1 -1.1 -0.4
Arm fat mass (right) 0.2 0.7 1.6 -0.6 0.0 -1.3 -1.3 0.3
Trunk predicted mass 0.7 4.2 14.4 -3.8 0.0 -2.3 1.2 -0.2
Standing height 0.2 2.1 5.1 -2.2 0.0 -1.5 1.4 -1.2
Length of working week for main job 0.3 0.3 1.2 0.2 0.0 -0.6 -1.1 0.3
Exposure to tobacco smoke at home 0.2 0.3 0.6 -0.4 0.0 0.7 -0.8 0.4
Breastfed as a baby 1.5 1.8 3.4 -1.8 0.0 -1.3 -1.7 -1.0
Tense / ‘highly strung’ 0.3 0.5 1.9 -1.4 0.0 -0.7 -0.1 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.7 0.8 0.0 -0.8 -0.9 -1.6
Hair/balding pattern: Pattern 4 0.4 1.0 2.7 -1.6 0.0 0.6 -1.2 0.9
Birth weight of first child 0.5 0.9 2.6 -0.5 0.0 -0.6 -1.1 -1.6
Peak expiratory flow (PEF) 0.1 0.3 1.0 0.1 0.0 -1.0 0.8 -0.1
Pulse wave reflection index 0.4 0.6 2.0 1.4 0.0 -0.3 -0.8 0.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.2 -1.1 0.0 -0.9 0.4 0.0
Loud music exposure frequency 1.1 1.2 3.6 0.1 0.0 -1.4 -0.9 -1.9
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.7 0.0 0.0 0.8 -0.1 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.3 -0.3 0.0 0.7 1.5 0.1
Blood clot in the leg (DVT) 0.4 0.5 2.1 0.7 0.0 0.1 -1.5 0.1
Medication: Paracetamol 0.8 1.3 3.6 1.9 0.0 -1.2 0.4 -1.1
Headache pain in last month 0.4 0.6 2.4 -0.6 0.0 -1.6 -0.6 -0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.2 0.5 0.2 0.0 -0.6 0.7 0.6
Glaucoma (self-reported) 0.7 0.8 2.2 -1.5 0.0 0.5 -1.1 0.2
Gout (self-reported) 0.3 0.4 1.8 1.3 0.0 -0.5 0.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.9 1.0 0.0 -0.0 -0.7 0.4
Medication: Amlodipine 0.4 0.6 1.1 -0.9 0.0 -1.1 0.6 0.6
Medication: Ventolin 100micrograms inhaler 1.3 1.7 4.6 2.1 0.0 1.8 0.9 0.1
Birth weight 0.1 0.2 0.6 -0.5 0.0 -0.6 0.1 -0.8
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.2 -0.7 0.0 0.7 -1.5 -1.5
High blood pressure (siblings) 0.5 0.7 3.3 -0.2 0.0 1.8 -0.5 -0.3
Forced vital capacity (FVC), Best measure 0.2 0.8 1.7 -1.3 0.0 -1.2 0.2 -0.9
Body fat percentage 0.3 1.0 4.0 1.0 0.0 -0.4 -2.0 -0.1
Leg fat percentage (right) 0.2 0.6 1.6 1.1 0.0 -0.0 -1.3 0.3
Arm fat-free mass (right) 0.6 2.9 9.4 -3.1 0.0 -2.1 0.7 -0.5
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.3 0.0 -0.3 0.0 0.5
Comparative body size at age 10 0.4 1.1 3.0 0.7 0.0 -1.1 -1.7 -0.8
Number of full brothers 0.8 1.0 2.8 -0.3 0.0 -0.9 -1.7 -1.0
Worry too long after embarrassment 0.2 0.3 1.5 -0.5 0.0 -1.2 -0.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 4.3 -2.1 0.0 -0.1 -0.8 -1.1
Wheeze or whistling in the chest in last year 0.6 1.0 2.6 0.8 0.0 -1.3 -1.6 -0.6
Number of children fathered 0.5 0.6 2.2 -1.5 0.0 -0.5 -0.7 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.6 -0.1 0.0 -1.0 -0.1 -1.2
Age at first live birth 0.3 0.5 1.1 0.5 0.0 0.9 1.0 0.3
Pulse wave peak to peak time 0.7 0.8 3.6 -0.2 0.0 1.9 0.2 0.5
Health satisfaction 0.4 0.5 1.7 1.3 0.0 0.4 0.6 0.4
Shortness of breath walking on level ground 0.6 0.7 2.8 -1.7 0.0 0.2 -0.7 0.2
Qualifications: College or University degree 0.9 2.9 9.2 -3.0 0.0 -1.3 -1.8 -0.7
Eye problems/disorders: None of the above 0.8 0.9 3.0 1.3 0.0 0.0 0.3 -1.7
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 1.1 0.0 0.8 0.7 -0.5
Emphysema/chronic bronchitis 0.7 0.8 3.2 1.8 0.0 -0.6 0.4 -0.3
Medication for pain relief, constipation, heartburn 0.6 1.0 3.6 -0.2 0.0 1.9 -0.3 1.1
Neck or shoulder pain in last month 0.3 0.4 1.3 -0.5 0.0 1.2 -0.5 0.1
Medication: Blood pressure 0.1 0.2 0.7 -0.2 0.0 0.7 -0.8 0.1
Angina (self-reported) 0.9 1.1 2.9 -0.2 0.0 -0.8 -1.7 -1.4
Migraine (self-reported) 0.7 0.9 2.2 -0.9 0.0 -1.0 -0.7 1.5
Medication: Ibuprofen 0.1 0.1 0.5 0.0 0.0 0.3 0.3 0.7
Medication: Allopurinol 0.9 1.2 5.2 2.3 0.0 -0.8 -0.0 -0.0
Medication: Omeprazole 0.7 0.8 2.3 1.5 0.0 0.3 0.9 -0.9
Medication: Seretide 50 evohaler 0.2 0.2 0.6 -0.1 0.0 -0.1 -0.6 -0.8
Mean time to correctly identify matches 0.3 0.5 1.7 1.3 0.0 0.2 0.3 0.8
Heart disease (mother) 2.4 2.9 11.4 -3.4 0.0 -0.3 -1.4 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 2.1 -1.4 0.0 0.0 -0.6 -0.5
Whole body fat mass 0.1 0.4 1.3 -0.2 0.0 -0.9 -1.1 0.1
Leg fat mass (right) 0.1 0.3 1.0 -0.2 0.0 -0.7 -1.0 0.3
Arm predicted mass (right) 0.4 2.2 7.0 -2.6 0.0 -1.9 0.6 -0.5
Pulse rate, automated reading 0.2 0.7 2.6 -0.1 0.0 0.9 -0.6 1.6
Alcohol intake frequency. 0.2 0.4 1.1 0.4 0.0 -1.0 0.4 -0.6
Comparative height size at age 10 0.2 0.9 2.1 -1.4 0.0 -1.2 0.8 0.4
Number of full sisters 0.3 0.3 0.8 0.9 0.0 0.3 0.3 -0.9
Suffer from ‘nerves’ 0.6 0.9 1.7 -0.2 0.0 -1.3 1.2 -1.2
Overall health rating 0.2 0.4 1.8 1.4 0.0 -0.3 -0.2 -0.3
Chest pain or discomfort 1.0 1.5 3.3 1.0 0.0 -1.7 -1.8 -0.5
Had major operations 0.3 0.3 1.0 0.5 0.0 0.0 0.6 1.0
Age at last live birth 0.6 0.8 3.7 0.5 0.0 0.1 1.9 0.4
Family relationship satisfaction 0.5 0.6 1.8 -0.1 0.0 -1.3 1.1 -0.1
Leg pain on walking 0.7 0.8 2.3 -1.1 0.0 0.1 -1.5 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.5 0.0 0.0 1.2 -0.1 -0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.6 1.4 1.0 0.0 -0.7 1.2 0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -0.7 0.0 -0.8 0.1 -1.0
Medication: Aspirin 0.0 0.0 0.1 0.2 0.0 0.3 0.3 0.1
Supplements: Vitamin C 1.0 1.2 2.5 1.5 0.0 1.0 1.6 0.4
Knee pain experienced in last month 0.8 1.3 5.5 -0.7 0.0 -2.4 -0.4 -0.5
Hypertension (Self-reported) 0.0 0.1 0.3 0.6 0.0 -0.3 -0.3 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.3 0.3 0.0 -1.1 1.1 0.4
Illnesses of father: Heart disease 0.6 0.9 4.2 -0.2 0.0 0.4 2.0 0.0
Illnesses of siblings: Diabetes 0.1 0.1 0.4 0.1 0.0 0.1 0.4 -0.6
Smoking status: Previous 0.8 1.2 4.6 -2.1 0.0 -0.9 0.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 5.1 -0.4 0.0 -2.2 0.4 -0.7
Whole body fat-free mass 0.7 3.7 13.0 -3.6 0.0 -2.2 0.7 -0.4
Leg fat-free mass (right) 0.5 2.9 10.7 -3.3 0.0 -1.9 0.0 -0.4
Arm fat percentage (left) 0.2 0.9 3.6 0.3 0.0 -0.8 -1.9 0.2
Average weekly red wine intake 0.2 0.3 1.5 0.1 0.0 0.1 -0.2 -1.2
Handedness (chirality/laterality): Left-handed 1.4 1.7 5.5 0.5 0.0 -2.3 0.4 -1.6
Mood swings 0.8 1.4 2.7 -0.4 0.0 -1.4 1.5 1.6
Loneliness, isolation 1.2 1.7 6.2 -2.5 0.0 -1.2 0.6 0.8
Long-standing illness, disability or infirmity 0.0 0.0 0.1 -0.1 0.0 -0.3 -0.3 -0.0
Ever had bowel cancer screening 0.5 0.6 1.4 -1.0 0.0 -0.5 -1.2 -0.6
Diabetes diagnosed by doctor 0.4 0.6 2.3 -0.5 0.0 0.4 0.4 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.1 1.1 0.0 -0.9 1.1 0.9
Friendships satisfaction 1.3 1.7 4.7 0.2 0.0 1.2 1.5 2.2
Qualifications: nursing, teaching 0.6 0.9 3.9 -2.0 0.0 -0.3 0.0 -0.5
Commuting to job workplace: Walk 0.4 0.5 1.0 -0.7 0.0 1.0 0.2 0.9
Eye problems/disorders: Cataract 0.2 0.3 0.8 -0.7 0.0 0.2 0.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.3 1.1 0.0 -0.3 -0.9 -0.3
Medication for cholesterol 0.5 0.8 2.2 -0.8 0.0 -0.0 1.5 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 -0.7 0.0 0.0 -0.5 -1.0
Back pain experienced in last month 0.2 0.3 1.5 1.2 0.0 -0.3 -0.3 0.1
Mineral and other dietary supplements 0.5 0.7 2.2 -1.0 0.0 -0.5 -1.5 -0.1
Breast cancer (self-reported) 0.4 0.5 2.0 0.4 0.0 -0.4 1.4 0.2
Asthma (self-reported) 0.3 0.5 2.0 0.3 0.0 0.6 -0.2 1.4
Osteoporosis (self-reported) 0.4 0.6 2.0 0.5 0.0 -0.7 -0.2 1.4
Osteoarthritis (self-reported) 0.6 0.7 2.8 0.1 0.0 -0.4 -1.7 -0.8
Medication: Aspirin 0.0 0.0 0.0 -0.1 0.0 0.2 0.1 -0.0
Medication: Gliclazide 0.4 0.4 0.9 0.4 0.0 0.9 0.8 0.7
Illnesses of father: None of the above (group 1) 0.8 1.0 3.0 -1.0 0.0 -1.7 -0.7 0.6
Smoking status: Current 0.2 0.3 1.3 1.1 0.0 -0.3 0.0 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.8 -0.1 0.0 -0.9 0.8 -0.0
Whole body water mass 0.6 3.6 12.7 -3.6 0.0 -2.2 0.7 -0.4
Leg predicted mass (right) 0.6 2.9 11.0 -3.3 0.0 -1.9 0.0 -0.4
Arm fat mass (left) 0.2 0.8 1.8 -0.5 0.0 -1.3 -1.3 0.2
Number of self-reported non-cancer illnesses 1.0 1.7 4.2 0.4 0.0 -0.2 -2.1 2.0
Average weekly champagne plus white wine intake 0.2 0.2 0.8 -0.5 0.0 -0.3 0.9 0.2
Miserableness 0.3 0.5 1.8 -1.3 0.0 -0.5 0.4 0.4
Guilty feelings 1.7 2.5 7.3 0.4 0.0 -2.7 2.0 -0.9
Wears glasses or contact lenses 0.5 0.6 2.5 -0.2 0.0 1.6 -0.1 0.7
Ever taken oral contraceptive pill 2.0 2.2 10.1 -3.2 0.0 -0.8 0.5 0.2
Hearing aid user 1.9 2.1 4.5 1.1 0.0 -1.2 -2.1 -1.9
Mother’s age at death 0.1 0.1 0.5 0.4 0.0 0.1 0.7 0.1
Financial situation satisfaction 0.8 1.0 3.4 1.9 0.0 -1.2 -0.1 0.5
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.6 0.1 0.0 0.8 0.3 -0.1
Commuting to job workplace: Public transport 0.4 0.5 1.7 -0.7 0.0 -0.1 -0.6 -1.3
Eye problems/disorders: Glaucoma 1.1 1.3 2.8 -1.7 0.0 1.0 -0.7 1.4
Medication: Blood pressure 0.3 0.6 1.2 0.6 0.0 -0.7 -0.9 -1.1
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.6 -1.6 0.0 -1.6 -0.4 0.8
Supplements: Fish oil (including cod liver oil) 1.3 1.7 6.6 1.0 0.0 0.4 2.6 0.8
High cholesterol (Self-reported) 0.4 0.6 1.3 0.9 0.0 -1.0 -0.3 -1.1
Medication: Bendroflumethiazide 0.6 1.0 2.7 -0.5 0.0 -1.6 0.8 -1.1
Medication: Paracetamol 0.6 1.0 2.8 0.6 0.0 -1.2 0.5 -1.7
Medication: Lisinopril 0.0 0.1 0.2 -0.3 0.0 -0.2 0.0 -0.4
Medication: Atorvastatin 0.1 0.1 0.2 -0.4 0.0 0.2 -0.2 0.4
Illnesses of father: High blood pressure 1.6 2.0 7.8 1.0 0.0 2.8 -1.0 0.6
Alcohol drinker status: Never 0.3 0.4 1.0 -0.4 0.0 0.5 -1.0 0.6
Ever smoked 0.8 1.4 4.2 -2.0 0.0 -1.7 0.3 -0.1
Basal metabolic rate 0.6 3.2 10.4 -3.2 0.0 -2.3 0.4 -0.4
Leg fat percentage (left) 0.1 0.4 1.2 0.7 0.0 -0.2 -1.1 0.1
Arm fat-free mass (left) 0.4 2.1 6.3 -2.5 0.0 -2.0 0.2 -0.4
Number of operations (self-reported) 0.4 0.5 1.3 1.1 0.0 -1.0 -0.6 0.2
Average weekly beer plus cider intake 1.0 1.4 3.9 0.6 0.0 -0.4 2.0 1.6
Irritability 0.5 0.8 2.4 -1.5 0.0 -1.1 0.1 -0.5
Risk taking 0.4 0.7 2.1 -1.4 0.0 -1.0 -0.3 0.1
Ever had prostate specific antigen (PSA) test 1.5 1.7 3.3 1.4 0.0 1.8 0.3 -1.7
Fractured/broken bones in last 5 years 1.0 1.3 2.6 1.3 0.0 -1.3 1.6 0.6
Age started oral contraceptive pill 0.1 0.1 0.3 -0.5 0.0 0.3 0.3 0.1
Diastolic blood pressure, automated reading 0.0 0.1 0.2 0.4 0.0 0.3 -0.2 0.2
Ever depressed for a whole week 0.5 0.6 1.6 -0.1 0.0 -1.1 1.2 -0.0
Unable to work because of sickness or disability 1.2 1.5 6.9 -0.1 0.0 -0.5 -2.6 -0.6
Commuting to job workplace: Cycle 1.1 1.4 6.1 -0.9 0.0 0.1 0.2 -2.5
Myopia 0.1 0.2 0.7 -0.3 0.0 -0.4 -0.8 -0.2
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.6 0.1 0.0 0.1 0.8 -0.4
Cholesterol lowering medication 0.3 0.4 1.6 0.5 0.0 -1.3 -0.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 0.5 0.0 0.3 -0.1 -0.5
Pain experienced in last month 0.6 1.1 3.9 0.3 0.0 2.0 -0.7 0.9
Supplements: Calcium 0.1 0.1 0.4 0.6 0.0 -0.3 0.0 -0.1
Basal cell carcinoma (self-reported) 0.2 0.3 0.9 0.1 0.0 -0.3 0.6 -1.0
Heart attack/myocardial infarction (self-reported) 0.6 0.7 2.4 -0.9 0.0 0.0 -0.6 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.9 0.9 0.0 0.4 -1.4 0.1
Heart disease (siblings) 0.8 1.0 2.6 0.5 0.0 1.1 -1.6 -0.9
Alcohol drinker status: Previous 0.7 0.8 3.6 0.0 0.0 0.1 -0.8 -1.9
Pack years of smoking 0.3 0.5 1.0 0.9 0.0 -0.6 -0.6 -1.0
Impedance of whole body 0.7 3.5 13.8 3.7 0.0 1.5 -0.8 -0.9
Leg fat mass (left) 0.1 0.4 1.0 -0.4 0.0 -0.8 -1.0 0.2
Arm predicted mass (left) 0.5 2.8 7.8 -2.8 0.0 -2.4 0.6 -0.3