TWAS hub - LSM4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.140	0.056	2.4e-03	-0.003	NA	0.001	NA	0.005	5.8e-01	NA	2.5e-01	NA	1.2e-01
2	YFS	Blood	0.187	0.033	3.7e-15	0.014	0.06	0.088	0.083	0.074	1.5e-05	7.8e-19	3.4e-27	6.6e-26	5.2e-23

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Breastfed as a baby	10.2	12.6	22.9	-4.8	1.5
Diabetes (mother)	5.8	7.4	8.1	2.8	-2.6
Mouth/teeth dental problems: Mouth ulcers	4.1	6.4	9.9	-3.1	-1.7
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	7.1	0.1	-2.7
Trunk fat percentage	3.2	12.6	25.0	5.0	0.5
Body fat percentage	3.1	12.4	24.7	5.0	0.4
Comparative body size at age 10	3.0	8.2	14.8	3.9	1.3
Arm fat percentage (right)	2.9	11.5	20.3	4.5	1.6
Family relationship satisfaction	2.8	3.4	6.9	-0.2	-2.6
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	7.7	-2.8	-1.7
Medication: Levothyroxine sodium	2.6	4.4	4.5	-2.1	-2.1
Waist circumference	2.6	9.5	18.9	4.3	0.3
Illnesses of mother	2.6	3.2	6.4	-2.5	0.2
Leg fat percentage (right)	2.6	9.4	18.7	4.3	-0.3
Arm fat percentage (left)	2.6	10.3	18.1	4.2	1.6
Friendships satisfaction	2.6	3.2	6.2	-0.4	-2.5
Blood Red Count	2.5	24.5	39.7	3.0	-6.3
Ever highly irritable/argumentative for 2 days	2.5	3.0	4.7	1.1	-2.2
Hypothyroidism (self reported)	2.4	5.6	7.1	-2.7	-2.0
Migraine (self-reported)	2.4	3.0	4.4	2.1	1.3
Whole body fat mass	2.4	10.0	19.8	4.5	0.4
Medication: Co-codamol	2.3	2.7	5.4	2.3	0.2
Prospective memory result	2.3	2.9	5.7	2.4	-0.2
Leg fat mass (right)	2.3	8.8	17.6	4.2	0.2
Leg fat percentage (left)	2.3	8.3	16.3	4.0	-0.5
Rheumatoid Arthritis	2.2	3.1	5.7	-2.4	0.6
Trunk fat mass	2.2	9.5	18.9	4.3	0.3
Alcohol usually taken with meals	2.2	3.6	6.1	-2.5	1.1
Had other major operations	2.2	2.7	4.9	2.2	0.7
Fed-up feelings	2.1	3.7	4.0	2.0	-1.9
Heart attack	2.1	2.7	5.2	-2.3	-0.4
Handedness (chirality/laterality): Left-handed	2.1	2.6	2.6	1.6	-1.6
Leg fat mass (left)	2.1	8.3	16.6	4.1	0.0
BMI	2.0	11.7	22.1	4.7	1.1
Happiness	2.0	2.4	4.8	0.1	-2.2
Myopia	2.0	2.9	5.2	-2.3	-0.7
Waist Hip Ratio (WHR)	1.9	8.8	17.1	4.1	-0.7
Arm fat mass (right)	1.9	7.6	14.4	3.8	0.9
Age at last live birth	1.9	2.8	5.3	0.5	-2.3
Arm fat mass (left)	1.9	7.6	14.4	3.8	0.9
Number of operations (self-reported)	1.9	2.8	3.5	1.4	1.9
Heart attack/myocardial infarction (self-reported)	1.9	2.4	4.8	-2.2	-0.3
Pack years adult smoking proportion	1.8	2.8	5.6	2.4	-0.2
Body mass index (BMI)	1.8	7.6	13.5	3.7	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.9	-0.2	-2.4
Neck or shoulder pain in last month	1.8	2.6	4.2	-2.0	-1.0
Pack years of smoking	1.8	2.7	5.3	2.3	-0.1
High blood pressure (mother)	1.7	2.3	3.8	2.0	-0.9
Impedance of leg (left)	1.7	8.1	15.6	-0.8	-4.0
Risk taking	1.7	2.5	4.9	-2.2	0.4
Diabetes (father)	1.6	2.0	4.0	2.0	-0.1
Qualifications: A levels/AS levels or equivalent	1.6	3.6	6.2	-2.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.7	1.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	3.5	-1.9	0.1
Illnesses of siblings: Diabetes	1.5	1.8	3.6	1.9	-0.3
Diastolic blood pressure, automated reading	1.5	4.7	5.7	1.9	-2.4
Neuroticism (Nagel 2018)	1.4	3.3	3.6	1.7	-1.9
Crohns Disease (2017)	1.4	3.0	3.4	-1.6	-1.8
Triglycerides	1.4	2.4	4.0	2.0	0.8
Sensitivity / hurt feelings	1.4	2.3	2.7	1.6	-1.4
Hair/balding pattern: Pattern 2	1.4	1.7	2.6	0.9	-1.6
Hair/balding pattern: Pattern 3	1.4	2.1	3.5	-1.9	0.8
Qualifications: College or University degree	1.4	4.6	6.8	-2.6	-1.5
Breast cancer (self-reported)	1.4	1.7	3.1	1.8	-0.5
Average weekly champagne plus white wine intake	1.4	1.9	1.9	-1.4	1.4
Schizophrenia vs Biploar Disorder	1.3	1.7	3.3	1.8	0.0
Fasting Glucose	1.3	1.6	1.9	-1.1	-1.4
Allergy or Eczema	1.3	3.3	6.6	-0.3	-2.6
Relative age of first facial hair	1.3	2.7	4.0	-2.0	1.1
Impedance of leg (right)	1.3	6.1	12.0	-0.5	-3.5
Diabetes (self-reported)	1.3	2.0	3.7	0.5	-1.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.1	-1.8	-0.5
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.6	-1.6	0.7
Ever depressed for a whole week	1.3	1.6	2.5	-1.6	-0.9
Ulcerative Colitis	1.2	1.7	2.1	1.5	-1.1
Blood Eosinophil Count	1.2	8.9	14.3	-1.9	-3.8
Cardiovascular Disease	1.2	3.8	7.1	0.7	-2.7
Lung FEV1/FVC ratio	1.2	6.0	11.9	3.5	-0.3
Relative age voice broke	1.2	1.8	3.3	-1.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.4	1.2	1.2
Loud music exposure frequency	1.2	1.3	2.4	0.5	1.5
Headache pain in last month	1.2	2.1	3.5	-0.9	-1.9
Mood swings	1.2	2.2	3.0	1.7	-1.2
Fractured/broken bones in last 5 years	1.2	1.5	2.3	1.5	0.8
Ulcerative Colitis (UC)	1.1	2.1	3.8	2.0	-0.6
Heel T-Score	1.1	9.0	17.9	-4.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	1.7	1.3	-1.3
Neuroticism score	1.1	2.4	4.1	0.8	-2.0
Falls in the last year	1.1	1.4	1.9	1.4	-1.0
Overall health rating	1.1	2.3	3.0	1.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.8	0.9	1.3
Medication: Paracetamol	1.1	1.8	3.2	1.8	-0.6
Irritability	1.1	1.8	2.0	1.4	-1.3
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	1.7	0.3
Mean Putamen Volume	1.0	1.1	1.5	-0.8	1.2
Blood White Count	1.0	7.6	8.3	2.9	-2.6
Neuroticism	1.0	2.5	2.9	1.4	-1.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.1	0.6	1.4
Weight	1.0	4.9	9.9	3.1	-0.1
Number of children fathered	1.0	1.1	2.0	-0.4	1.4
Guilty feelings	1.0	1.5	2.8	0.5	1.7
Medication: Blood pressure	1.0	2.0	2.5	1.6	-1.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.3	0.4	1.5
Depressed Affect (Nagel 2018)	0.9	1.8	2.1	1.5	-1.2
Vitamin and mineral supplements	0.9	1.2	1.8	1.3	0.7
Age when periods started (menarche)	0.9	2.2	4.4	-2.1	0.1
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.2	-0.8	-1.8
Supplements: Glucosamine	0.9	1.1	2.2	0.1	-1.5
Pain all over the body in last month	0.9	0.9	1.6	0.5	-1.3
Leg pain on walking	0.9	1.1	2.1	-0.0	1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	-1.4	-0.5
Supplements: Calcium	0.9	1.0	2.0	1.4	-0.0
Crohns Disease (2012)	0.8	1.4	1.7	-1.0	-1.3
Primary Biliary Cirrhosis	0.8	1.1	2.1	-1.4	-0.3
Schizophrenia (2014)	0.8	1.8	2.7	0.9	1.6
Systolic Blood Pressure	0.8	4.1	4.2	2.0	-2.0
Hand grip strength (left)	0.8	2.0	2.9	-1.7	-1.1
Medication for hormone replacement therapy	0.8	0.9	1.6	1.3	0.4
Allergy	0.8	1.8	3.7	0.1	1.9
Worrier / anxious feelings	0.8	1.5	2.8	0.5	-1.7
Length of working week for main job	0.8	0.9	1.2	-1.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.4	0.0	-1.6
Worry too long after embarrassment	0.8	1.3	2.4	0.4	-1.6
Eye problems/disorders: None of the above	0.8	0.9	1.0	-1.0	-0.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.7	-1.3	0.3
Medication for pain relief, constipation, heartburn	0.8	1.4	2.5	-1.6	-0.6
Comparative height size at age 10	0.8	4.3	5.7	1.7	-2.4
Number of full sisters	0.8	0.9	1.8	-0.2	-1.4
Long-standing illness, disability or infirmity	0.8	1.2	2.2	-0.3	-1.5
Worry (Nagel 2018)	0.7	1.5	2.6	0.7	-1.6
Irritable Bowel Disease (IBD)	0.7	1.7	3.2	0.3	-1.8
Average weekly fortified wine intake	0.7	0.8	1.6	-0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.1	-1.0	1.4
High blood pressure	0.7	2.0	3.6	0.6	-1.9
Nervous feelings	0.7	1.2	2.2	0.5	-1.5
Hearing difficulty/problems with background noise	0.7	1.1	2.2	-0.2	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.1	-1.0	1.5
Hip circumference	0.7	3.2	6.4	2.5	0.1
Pulse rate	0.7	1.2	2.3	0.4	-1.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.0	0.9	1.0
Medication: Amlodipine	0.7	1.0	1.2	0.9	1.1
Shortness of breath walking on level ground	0.7	0.8	1.0	0.8	1.0
Average weekly red wine intake	0.7	1.1	2.2	-1.5	0.0
Diabetes diagnosed by doctor	0.7	1.2	2.2	0.3	-1.5
Medication for cholesterol	0.7	1.0	2.0	-1.4	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.1	-0.7	-1.1
Commuting to job workplace: Public transport	0.7	0.8	1.6	1.2	0.3
Average weekly beer plus cider intake	0.7	0.9	1.2	1.1	-0.9
Unable to work because of sickness or disability	0.7	0.9	1.6	0.4	1.2
HbA1C	0.6	0.6	1.1	1.1	0.4
Height	0.6	11.6	23.0	-0.5	-4.8
Supplements: Zinc	0.6	0.7	1.2	-0.4	-1.1
Severe depression (siblings)	0.6	0.6	1.3	-1.1	-0.1
Stomach or abdominal pain in last month	0.6	0.7	1.4	0.0	-1.2
Forced vital capacity (FVC)	0.6	2.3	2.4	-1.6	-1.5
Noisy workplace	0.6	0.8	0.9	-0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	0.8	0.8	0.9
Exposure to tobacco smoke at home	0.6	0.6	1.2	-0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.5	-1.2	-0.5
Blood clot in the leg (DVT)	0.6	0.8	1.4	0.5	-1.2
Medication: Paracetamol	0.6	1.0	1.9	1.4	-0.1
Emphysema/chronic bronchitis	0.6	0.6	1.1	-0.5	-1.0
Medication: Ibuprofen	0.6	0.8	1.3	1.1	0.5
Chest pain or discomfort	0.6	0.9	1.4	-1.2	-0.7
Smoking status: Previous	0.6	0.9	1.7	1.3	0.2
Qualifications: nursing, teaching	0.6	1.0	1.9	-1.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.1	1.1	0.6
Mineral and other dietary supplements	0.6	0.8	1.3	0.5	1.1
Osteoporosis (self-reported)	0.6	0.7	1.1	-0.5	-1.1
Miserableness	0.6	1.0	1.2	0.9	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.3	-1.2
Vascular/heart problems diagnosed by doctor	0.6	1.5	3.0	-0.1	1.7
Alcohol drinker status: Previous	0.6	0.6	1.2	-1.1	-0.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-0.5	1.0
Alzheimer’s Disease (in father)	0.5	0.5	0.7	0.6	-0.8
Neuroticism (2016)	0.5	0.8	1.0	1.0	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.7	0.5	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	-0.1	-1.1
Systolic blood pressure, automated reading	0.5	1.6	3.0	1.7	-0.4
Leg fat-free mass (left)	0.5	2.9	4.6	2.1	1.1
Current tobacco smoking	0.5	0.8	0.9	0.9	1.0
Leg predicted mass (left)	0.5	2.9	4.4	2.1	1.2
Medication: Cholesterol lowering	0.5	0.8	1.2	-1.1	-0.6
Standing height	0.5	4.9	8.9	-0.9	-3.0
Glaucoma (self-reported)	0.5	0.6	1.0	1.0	-0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	0.8	-0.9	-0.8
High blood pressure (siblings)	0.5	0.7	1.3	-0.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.8	-0.7	-0.9
Hypertension (Self-reported)	0.5	1.4	2.3	0.7	-1.5
Commuting to job workplace: Walk	0.5	0.6	1.0	0.4	-1.0
Mother’s age at death	0.5	0.7	0.8	0.9	0.8
Ever smoked	0.5	0.8	1.6	1.2	-0.3
Pain experienced in last month	0.5	0.8	1.4	0.5	1.2
Impedance of whole body	0.5	2.3	4.5	0.4	-2.1
Reaction Time	0.4	0.7	1.4	1.2	0.1
Breast Cancer	0.4	1.0	1.6	-1.2	0.7
LDL Cholesterol	0.4	0.7	1.2	1.1	0.5
Lupus	0.4	0.7	0.8	-0.9	-0.7
Respiratory disease	0.4	0.9	1.7	-1.3	0.3
Average weekly spirits intake	0.4	0.5	0.8	0.4	-0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.8	0.9	-0.6
Hand grip strength (right)	0.4	1.2	1.3	-1.1	-1.1
Maternal smoking around birth	0.4	0.6	0.7	-0.7	-0.9
Multivitamins +/- minerals	0.4	0.5	0.8	-0.5	-0.9
Medication: Atenolol	0.4	0.5	0.7	0.9	0.5
Past tobacco smoking	0.4	0.7	1.4	-1.2	0.2
Qualifications: None of the above	0.4	0.9	1.0	0.9	1.0
Father’s age at death	0.4	0.5	0.9	0.9	0.3
Asthma	0.4	0.8	1.1	-1.0	0.8
Birth weight of first child	0.4	0.7	1.1	1.0	0.6
Peak expiratory flow (PEF)	0.4	0.9	1.3	-1.1	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	1.6	-1.3	-1.1
Number of full brothers	0.4	0.5	1.0	0.2	-1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	-0.2	1.1
Pulse wave peak to peak time	0.4	0.5	0.8	-0.9	-0.5
Pulse rate, automated reading	0.4	1.2	1.9	0.7	-1.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.9	-1.0	-0.2
Ever had bowel cancer screening	0.4	0.5	1.0	0.0	1.0
Medication: Gliclazide	0.4	0.4	0.8	-0.1	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	1.0	0.2
Smoking status: Current	0.4	0.7	1.1	0.5	1.0
Number of self-reported non-cancer illnesses	0.4	0.6	1.1	-1.1	0.4
Medication: Bendroflumethiazide	0.4	0.7	1.2	0.4	-1.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	0.9	0.1
Cholesterol lowering medication	0.4	0.6	0.8	0.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	0.1	-1.0
Schizophrenia (2018)	0.3	0.7	1.1	0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	1.3	0.2
Ovarian Cancer	0.3	0.3	0.6	-0.8	-0.3
Chronotype (morning person)	0.3	0.8	1.1	-0.6	1.1
Number of treatments/medications taken	0.3	0.6	1.0	1.0	-0.4
Hearing difficulty/problems: Yes	0.3	0.4	0.5	0.7	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	-0.4	0.7
Had menopause	0.3	0.4	0.6	-0.4	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.4	-0.7	0.5
Mouth/teeth dental problems	0.3	0.5	1.1	1.0	-0.1
Medication: Simvastatin	0.3	0.4	0.7	-0.4	-0.8
Illnesses of siblings	0.3	0.4	0.8	-0.9	0.2
Time employed in main current job	0.3	0.3	0.6	-0.8	-0.3
Number of live births	0.3	0.4	0.5	0.5	-0.7
Lung cancer (father)	0.3	0.3	0.6	-0.0	0.8
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.9	0.1
Tense / ‘highly strung’	0.3	0.5	1.0	-0.2	-1.0
Hair/balding pattern: Pattern 4	0.3	0.6	0.8	0.9	-0.7
Gout (self-reported)	0.3	0.4	0.8	0.1	0.9
Birth weight	0.3	0.6	1.0	0.4	-1.0
Medication: Blood pressure	0.3	0.6	1.2	-1.1	-0.1
Heart disease (mother)	0.3	0.4	0.5	0.6	-0.7
Leg fat-free mass (right)	0.3	1.9	2.8	1.7	1.0
Asthma (self-reported)	0.3	0.7	0.7	-0.8	0.8
Medication: Aspirin	0.3	0.4	0.8	-0.9	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.8	-0.9	-0.7
Leg predicted mass (right)	0.3	1.9	2.8	1.7	1.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.3	0.6	-0.5
High cholesterol (Self-reported)	0.3	0.6	0.8	-0.7	-0.9
Alcohol drinker status: Never	0.3	0.3	0.5	0.4	0.7
Commuting to job workplace: Cycle	0.3	0.3	0.4	0.6	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.6	0.9	0.5	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.5	-0.7	0.6
Prostate Cancer	0.2	0.3	0.5	0.2	0.7
HDL Cholesterol	0.2	0.3	0.4	-0.6	-0.5
Blood Platelet Count	0.2	2.3	4.6	0.1	2.1
Angina	0.2	0.3	0.6	-0.2	0.8
Serious illness, injury or assault to yourself	0.2	0.3	0.3	-0.5	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.1	-0.8	-1.0
Pulse wave reflection index	0.2	0.3	0.5	0.3	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	0.2
Arm fat-free mass (right)	0.2	0.8	1.1	0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.3	-0.6
Age at first live birth	0.2	0.3	0.7	0.1	-0.8
Angina (self-reported)	0.2	0.2	0.5	0.0	0.7
Medication: Omeprazole	0.2	0.2	0.2	0.4	-0.5
Medication: Aspirin	0.2	0.2	0.4	-0.6	0.1
Knee pain experienced in last month	0.2	0.3	0.5	-0.4	-0.7
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.8	-0.3
Loneliness, isolation	0.2	0.2	0.4	-0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.5	-0.4
Hearing aid user	0.2	0.2	0.3	0.4	-0.5
Medication: Lisinopril	0.2	0.3	0.6	-0.7	-0.1
Arm fat-free mass (left)	0.2	1.1	1.1	1.0	-1.1
Age started oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.1	0.6
Heart disease (siblings)	0.2	0.2	0.4	0.6	0.2
Arm predicted mass (left)	0.2	0.9	1.0	0.9	-1.0
Bipolar Disorder (2018)	0.1	0.1	0.1	0.2	0.4
Age at First Birth	0.1	0.2	0.2	-0.4	0.3
Smoking Status	0.1	0.3	0.6	0.2	0.8
Lung FVC	0.1	0.7	0.8	-0.8	0.9
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.6	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.3	0.3
Sitting height	0.1	0.6	0.8	-0.6	-0.9
Number of incorrect matches in round	0.1	0.2	0.5	0.0	-0.7
Financial difficulties in last 2 years	0.1	0.1	0.1	0.2	-0.3
Medication: Ramipril	0.1	0.1	0.1	0.1	-0.4
Impedance of arm (right)	0.1	0.6	1.3	1.1	-0.0
Trunk fat-free mass	0.1	0.4	0.6	-0.4	-0.8
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.7	0.0
Depression (self-reported)	0.1	0.1	0.2	-0.3	0.4
Medication: Lansoprazole	0.1	0.1	0.1	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	-0.3	-0.8
Trunk predicted mass	0.1	0.4	0.7	-0.4	-0.9
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.1	-0.6
Health satisfaction	0.1	0.1	0.1	0.3	-0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.3	-0.1	-0.6
Mean time to correctly identify matches	0.1	0.2	0.4	0.3	0.6
Arm predicted mass (right)	0.1	0.6	0.8	0.6	-0.9
Alcohol intake frequency.	0.1	0.2	0.3	-0.4	0.6
Had major operations	0.1	0.1	0.2	-0.5	0.1
Supplements: Vitamin C	0.1	0.1	0.1	-0.4	-0.1
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.0	0.6
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.4	-0.3
Financial situation satisfaction	0.1	0.1	0.2	0.4	-0.3
Medication: Atorvastatin	0.1	0.1	0.1	0.3	0.1
Basal metabolic rate	0.1	0.8	1.6	1.3	-0.1
Depression (Nagel 2018)	0.0	0.0	0.0	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.2	-0.5	0.3
Tanning	0.0	0.0	0.0	0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	0.2	-0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	0.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.1	0.2
Medication: Metformin	0.0	0.1	0.1	-0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.3	-0.0
Taking other prescription medications	0.0	0.0	0.0	0.1	-0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.0	0.1	0.2
Fluid intelligence score	0.0	0.0	0.0	0.0	-0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.0	0.0
Impedance of arm (left)	0.0	0.2	0.3	0.5	-0.4
Medication: Allopurinol	0.0	0.1	0.1	-0.3	-0.0
Suffer from ‘nerves’	0.0	0.1	0.1	-0.3	-0.0
Whole body fat-free mass	0.0	0.2	0.5	0.7	-0.1
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.0	-0.0
Back pain experienced in last month	0.0	0.1	0.1	0.3	0.3
Whole body water mass	0.0	0.3	0.5	0.7	-0.2
Wears glasses or contact lenses	0.0	0.0	0.0	-0.2	-0.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	-0.2	-0.2

Hub : Genes

LSM4

Models

Trait associations