Hub : Genes

LSM6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0230	2.8e-09	0.136	0.085	0.127	0.121	0.133	3.3e-16	1.4e-10	3.0e-15	1.5e-14	7.5e-16
2	GTEx	Brain Caudate basal ganglia	0.3890	0.0990	2.9e-04	0.058	NA	0.119	NA	0.066	9.4e-03	NA	2.9e-04	NA	5.8e-03
3	GTEx	Brain Cortex	0.3140	0.0980	8.6e-04	-0.010	NA	0.064	NA	0.022	7.5e-01	NA	7.8e-03	NA	8.2e-02
4	GTEx	Brain Frontal Cortex BA9	0.2859	0.1006	6.5e-03	0.133	NA	0.103	NA	0.092	2.2e-04	NA	1.1e-03	NA	2.0e-03
5	GTEx	Testis	0.1410	0.0570	5.5e-03	0.059	NA	0.041	NA	0.027	1.3e-03	NA	6.4e-03	NA	2.3e-02
6	GTEx	Thyroid	0.0740	0.0310	3.6e-03	0.024	NA	-0.002	NA	0.022	6.0e-03	NA	4.9e-01	NA	7.9e-03
7	ROSMAP	Brain Pre-frontal Cortex	0.1317	0.0304	2.0e-13	0.150	0.118	0.120	0.131	0.140	8.9e-19	6.0e-15	3.5e-15	1.8e-16	1.2e-17
8	YFS	Blood	0.0646	0.0219	7.2e-06	0.000	0.008	0.027	0.011	0.024	2.8e-01	6.8e-04	1.9e-09	8.4e-05	2.1e-08
9	TCGA	Colon Adenocarcinoma	0.1310	0.0780	5.5e-03	0.000	0.035	0.033	NA	0.008	3.3e-01	4.1e-03	5.4e-03	NA	1.0e-01
10	TCGA	Prostate Adenocarcinoma	0.0411	0.0236	5.9e-04	0.032	0.029	0.023	NA	0.027	2.3e-04	5.1e-04	1.5e-03	NA	7.7e-04
11	TCGA	Stomach Adenocarcinoma	0.0650	0.0450	4.3e-03	0.014	0.020	0.002	NA	0.012	3.2e-02	1.2e-02	2.1e-01	NA	4.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.0	1.5	7.4	-1.5	-0.6	-0.6	-1.3	-2.7	0.8	-1.4	-0.6	-0.3	0.9	-0.9
Bipolar Disorder or Schizophrenia	0.0	0.1	0.5	-0.1	0.3	-0.0	-0.1	-0.7	-0.2	-0.1	0.0	-0.4	0.1	-0.3
Depressed Affect (Nagel 2018)	0.6	1.2	4.6	-1.3	-0.7	0.3	-0.8	-1.1	0.9	-1.4	2.1	0.5	1.0	-0.6
Depression (Nagel 2018)	0.4	0.6	2.3	0.6	0.1	0.0	1.0	-1.0	-0.8	0.7	1.5	-0.2	-0.7	-0.0
Intelligence (Savage-Jansen 2018)	1.7	5.1	11.8	-2.5	-2.4	-1.3	-3.4	-2.7	1.7	-2.5	-1.4	-1.8	1.3	-2.9
Neuroticism (Nagel 2018)	0.5	1.1	2.4	-1.3	-0.5	0.4	-1.1	-0.9	1.1	-1.4	1.5	0.5	1.1	-1.0
Schizophrenia (2018)	0.3	0.7	1.7	1.1	1.0	0.6	1.0	1.3	-0.9	1.1	0.5	-0.2	-0.6	0.4
Schizophrenia vs Biploar Disorder	1.0	1.3	4.2	1.0	-0.3	-1.8	1.0	2.0	-0.7	1.0	0.8	-1.2	-1.1	-0.4
Worry (Nagel 2018)	0.5	1.1	3.2	-1.5	-0.5	0.8	-1.1	-0.8	0.9	-1.5	0.3	-0.2	0.7	-1.8
Alzheimer’s Disease (in mother)	1.3	1.5	4.2	1.5	2.1	0.6	0.9	0.2	-1.4	1.6	-1.1	-0.1	-1.0	1.6
Alzheimer’s Disease (in father)	0.5	0.5	3.1	0.2	0.7	1.8	0.4	0.3	-0.2	0.2	-1.0	-0.4	0.1	-0.3
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	1.2	2.0	1.4	0.8	0.8	-1.3	1.3	-1.1	-0.1	-0.6	1.1
Crohns Disease (2017)	1.0	2.2	4.7	1.6	1.5	0.3	2.0	0.6	-2.2	1.7	0.8	-1.9	-1.9	-0.1
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	0.9	0.6	0.5	1.3	0.5	-1.3	1.0	0.7	-1.1	-0.9	-0.0
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.0	-0.7	0.2	0.5	-0.0	-0.5	0.1	0.2	-0.7	-0.2	-0.4
Major Depression (MDD)	0.6	0.8	4.4	0.5	0.8	0.7	0.5	0.2	-0.7	0.6	2.1	-0.6	-1.1	-0.2
Reaction Time	0.6	1.2	5.1	0.9	1.4	2.3	0.4	1.5	-1.2	0.9	-0.5	0.1	-0.4	-0.0
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.8	-1.7	-0.9	-0.9	-1.9	-1.7	1.2	-1.7	-1.3	-0.4	1.3	-1.0
Breast Cancer	0.3	0.7	3.6	-0.2	-0.9	-1.9	-0.1	0.4	0.6	-0.3	1.1	-1.0	0.2	-0.2
Ovarian Cancer	0.9	1.2	6.0	1.0	2.5	-0.5	-0.0	-0.7	-0.4	0.9	0.3	0.8	0.3	1.8
Prostate Cancer	3.6	5.0	9.8	3.1	1.9	0.3	3.1	2.7	-2.4	3.1	-0.7	0.3	-2.5	1.6
Age at First Birth	1.1	1.7	6.0	-1.0	-2.5	-0.8	-1.0	-1.1	-0.2	-0.9	-2.0	-0.7	-0.6	-1.6
Bipolar Disorder (2011)	1.0	1.0	2.0	-1.4	-0.3	-1.1	-0.6	-0.7	1.1	-1.4	1.3	0.3	1.2	-0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.5	0.8	0.5	1.1	0.5	-1.0	-0.6	0.8	0.0	-1.2	-0.3	0.4
Coronary Artery Disease (CAD)	1.4	1.7	6.9	-0.9	1.5	-0.4	-0.1	0.3	1.1	-0.9	1.0	2.6	1.5	1.8
Crohns Disease (2012)	0.7	1.1	2.2	1.4	0.7	-0.4	1.5	-0.4	-1.3	1.4	0.2	-1.4	-1.0	0.6
Mean Putamen Volume	0.8	0.9	2.3	1.3	1.5	0.7	1.1	0.1	-0.5	1.2	0.4	-0.3	-0.3	1.5
Fasting Glucose	1.9	2.2	4.2	1.9	2.0	-0.2	1.4	1.8	-2.1	2.0	0.4	-0.8	-1.6	0.6
HbA1C	0.5	0.5	2.4	0.0	-0.5	-0.6	0.1	-1.6	0.3	0.0	0.5	-1.3	-0.7	-0.7
HDL Cholesterol	0.3	0.5	2.2	0.4	-0.1	-1.3	-0.0	1.5	-0.3	0.4	0.7	0.4	-0.7	0.1
LDL Cholesterol	0.3	0.4	1.6	0.2	0.9	0.9	-0.2	-0.7	-0.8	0.3	-1.2	0.0	-0.3	-0.0
Lupus	0.9	1.4	5.1	-1.1	0.1	-2.3	-1.3	-1.2	1.2	-1.1	0.3	1.0	1.6	0.3
Neuroticism (2016)	0.4	0.5	2.1	-0.4	-0.4	0.6	-0.3	-0.6	-0.6	-0.3	-0.3	-1.3	-0.6	-1.5
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.7	0.3	0.1	0.6	0.3	-0.9	0.7	-1.0	-0.8	-0.8	-0.0
Rheumatoid Arthritis	2.5	3.4	8.7	2.1	3.0	0.1	2.5	2.5	-0.9	2.0	-0.1	1.2	-0.4	2.4
Schizophrenia (2014)	0.0	0.1	0.7	0.2	0.4	-0.8	0.1	0.0	-0.2	0.2	0.1	-0.4	-0.1	-0.1
Triglycerides	0.3	0.6	2.0	0.1	0.8	1.1	-0.3	-1.4	-0.0	0.1	-1.3	-0.2	0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.3	1.0	0.1	0.4	-0.4	0.6	0.2	-0.0	0.6	0.8	1.2
Ulcerative Colitis	0.1	0.1	0.5	0.0	-0.7	0.7	0.5	0.0	-0.2	0.1	0.4	-0.5	0.2	-0.2
Blood Eosinophil Count	0.1	0.4	1.0	0.7	-0.4	0.5	0.9	0.0	-0.3	0.6	1.0	0.5	0.4	0.9
Blood Platelet Count	0.1	0.8	1.7	0.5	1.1	1.3	0.4	-1.2	-0.1	0.5	-0.9	1.3	0.0	1.1
Blood Red Count	0.1	0.8	1.7	-0.8	0.1	-1.0	-0.6	-1.3	1.2	-0.9	-0.1	1.2	0.9	1.1
Blood White Count	0.1	0.7	4.0	0.6	0.1	0.7	1.0	-2.0	-0.5	0.5	0.0	0.4	-0.8	0.8
Heel T-Score	2.0	15.7	51.8	-4.5	-4.2	-2.9	-4.8	-7.2	4.1	-4.5	0.4	1.1	3.2	-1.6
BMI	2.0	11.7	23.6	4.8	3.1	1.6	4.3	1.7	-4.4	4.9	-0.8	-2.4	-4.1	2.3
Height	0.1	1.1	3.6	-0.7	0.4	0.6	-0.1	1.6	0.7	-0.7	1.9	-0.7	0.8	-1.5
Waist Hip Ratio (WHR)	0.5	2.4	4.6	1.8	1.8	0.4	1.9	1.7	-1.6	1.8	2.1	0.0	-1.2	1.2
Systolic Blood Pressure	0.1	0.4	1.0	0.3	0.8	-0.2	0.3	0.2	-0.1	0.4	-0.8	1.0	-0.6	0.9
Smoking Status	0.6	1.3	7.4	0.4	1.6	0.5	-0.1	1.7	-0.3	0.4	2.7	0.9	-0.2	0.6
Allergy or Eczema	0.4	1.1	4.9	0.5	-0.5	-1.2	0.4	-1.7	0.2	0.4	-0.9	1.1	0.2	2.2
Cardiovascular Disease	0.4	1.5	4.2	1.1	-0.2	-1.0	1.5	-2.1	-1.1	1.1	-0.4	-1.4	-1.5	0.8
Hypothyroidism (self reported)	1.0	2.4	5.6	1.5	0.7	2.0	1.0	1.8	-1.6	1.6	0.5	-2.4	-1.5	-1.1
Respiratory disease	0.6	1.4	4.2	1.2	0.4	0.0	1.5	0.4	-1.8	1.3	0.9	-0.9	-2.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.6	1.0	1.7	1.9	0.9	0.5	-1.4	1.0	-0.2	-0.8	-1.0	0.4
Lung FEV1/FVC ratio	0.3	1.3	5.8	0.1	-0.7	-0.4	0.0	-1.8	0.1	0.1	-2.4	1.0	0.5	1.8
Lung FVC	0.6	2.8	7.4	1.0	0.5	1.2	0.5	2.0	-2.0	1.1	-2.7	-2.3	-2.0	-1.4
Neuroticism	0.8	2.0	5.8	-2.0	-0.7	0.4	-2.0	-1.1	0.9	-1.9	0.8	-0.6	0.7	-2.4
Chronotype (morning person)	0.8	1.9	6.0	1.5	0.4	-0.0	2.4	2.0	-1.1	1.4	1.1	0.0	-1.4	1.1
Hair Pigment	0.1	2.6	6.5	-1.6	-0.6	-0.3	-2.0	-0.4	2.5	-1.7	2.5	1.0	2.1	-0.5
Tanning	0.1	0.6	3.2	-0.4	-1.8	-0.6	0.0	-1.0	-0.1	-0.3	-1.0	-0.7	-0.8	-0.3
Hand grip strength (left)	0.5	1.3	2.9	1.7	0.9	0.9	1.7	0.7	-1.2	1.7	-0.2	-0.2	-1.3	0.5
Number of treatments/medications taken	1.4	2.5	6.2	1.8	1.4	0.4	1.9	1.4	-2.5	1.9	0.2	-1.0	-2.4	0.4
Average weekly spirits intake	0.6	0.8	2.0	1.0	-0.3	0.5	0.7	1.4	-0.9	1.0	-0.1	-1.0	-0.9	-1.0
Sensitivity / hurt feelings	0.3	0.5	2.1	0.5	1.4	1.4	-0.4	-0.1	-0.3	0.4	-0.9	0.1	0.5	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.8	0.1	0.1	-0.2	0.5	-0.0	-0.2	0.2	1.3	0.5	-0.1	0.3
Hearing difficulty/problems: Yes	0.6	0.9	2.6	0.5	0.8	1.0	0.1	-0.3	-1.5	0.7	0.2	-1.6	-1.3	-1.2
Relative age of first facial hair	0.4	0.9	5.2	0.7	0.6	0.3	0.9	-0.3	0.6	0.5	-0.0	1.1	0.8	2.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.4	-0.7	0.3	-0.6	-0.9	-1.5	1.4	-0.9	1.4	0.3	1.5	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.0	-0.3	0.0	-0.3	-0.1	-1.0	0.3	-0.3	-0.3	-0.9	-0.4	-0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.1	-0.6	0.5	0.3	-0.3	-0.1	-0.1	0.5	0.6	-0.1	0.5
Systolic blood pressure, automated reading	0.4	1.0	3.3	1.1	1.8	-0.6	1.0	0.0	-0.5	1.1	0.3	1.0	-0.9	1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.9	1.0	1.1	-0.4	0.7	0.9	-1.4	1.0	-0.7	-1.0	-0.9	0.5
Angina	1.0	1.3	7.1	1.0	1.4	2.7	0.5	0.6	-0.9	1.0	0.9	0.2	-0.8	0.3
Medication for hormone replacement therapy	0.4	0.5	2.1	0.5	0.1	0.1	0.7	-0.7	-0.4	0.5	-0.4	-1.4	-1.1	-0.3
Vitamin and mineral supplements	0.6	0.9	3.1	-0.6	-1.8	-1.7	0.9	-0.0	0.6	-0.7	1.2	0.2	0.2	0.0
Supplements: Zinc	0.5	0.5	1.7	-0.3	0.8	-0.5	-1.2	0.0	0.6	-0.3	1.3	0.5	0.8	0.1
Medication: Co-codamol	1.0	1.1	3.6	1.0	1.9	1.8	0.4	0.7	-0.7	1.0	-0.3	1.0	-0.2	1.4
Medication: Metformin	0.8	1.1	2.6	0.8	1.4	1.3	0.9	1.4	-0.7	0.8	1.6	0.5	-0.4	1.1
Diabetes (father)	1.0	1.2	5.4	-1.4	0.1	-0.9	-2.3	-1.5	0.4	-1.2	0.5	-0.2	0.9	-0.6
Diabetes (mother)	1.0	1.3	3.4	1.5	1.0	1.8	1.2	0.7	-1.0	1.5	0.4	0.3	-0.6	1.3
Severe depression (siblings)	0.4	0.4	2.0	-0.4	0.6	1.4	-1.0	-0.1	0.1	-0.3	-0.1	1.1	0.4	-0.0
Pack years adult smoking proportion	0.6	0.9	2.1	0.9	1.3	0.5	1.3	0.1	-1.3	1.0	-0.2	-0.7	-1.5	-0.0
Impedance of leg (right)	0.3	1.6	4.3	-1.0	1.1	-0.0	-0.9	-0.3	1.9	-1.1	0.7	2.1	2.0	0.8
Leg fat-free mass (left)	0.6	3.0	8.1	1.8	0.9	1.1	2.0	0.7	-2.4	1.9	0.4	-2.8	-2.4	-0.4
Trunk fat percentage	1.6	6.2	12.2	3.3	2.2	0.6	3.3	1.5	-3.5	3.3	1.0	-2.2	-3.1	1.1
Hand grip strength (right)	0.3	0.8	2.6	0.8	0.1	-0.3	0.6	0.4	-1.0	0.9	-1.2	-1.0	-1.6	-0.9
Townsend deprivation index at recruitment	0.3	0.4	1.3	0.4	0.3	-0.8	-0.3	0.3	-0.8	0.5	0.8	-0.3	-0.5	-1.1
Current tobacco smoking	0.4	0.6	2.7	-0.3	1.4	-0.1	-0.5	0.1	0.2	-0.2	1.6	1.1	0.1	0.4
Average weekly fortified wine intake	0.7	0.9	2.0	-1.1	-0.9	-0.7	-1.4	-0.6	1.0	-1.1	-1.0	0.5	1.1	-0.5
Maternal smoking around birth	1.0	1.4	5.1	0.5	0.4	2.3	0.5	1.1	-1.5	0.5	-0.4	-1.7	-1.7	-0.9
Fed-up feelings	0.3	0.6	2.0	0.6	1.4	0.5	0.6	0.3	-1.0	0.6	0.4	-1.0	-0.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.3	0.9	0.4	0.6	0.9	-0.4	-1.0	1.0	0.6	-0.5	-1.1	0.6
Relative age voice broke	1.1	1.6	3.2	-1.8	-0.6	-1.5	-1.6	-1.7	1.4	-1.7	-0.1	0.6	1.0	-0.5
Taking other prescription medications	3.0	4.7	10.4	2.6	1.2	1.4	2.9	3.2	-2.3	2.6	1.5	-1.0	-2.4	1.1
Age when periods started (menarche)	0.6	1.4	3.0	0.9	-0.1	1.2	0.4	-0.8	-1.4	1.0	-1.6	-1.5	-1.7	-1.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	-0.4	-0.6	1.0	-0.3	-0.1	0.1	-0.4	-0.2	0.3	-0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.1	-1.5	-1.5	0.3	-2.0	-2.3	1.8	-1.6	1.1	-0.3	1.3	-1.1
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	5.8	0.6	-0.3	0.6	0.9	0.6	-1.3	0.6	0.5	-2.4	-1.5	-1.5
Qualifications: CSEs or equivalent	1.3	1.7	4.1	2.0	1.5	0.4	0.6	1.6	-1.4	2.0	-0.6	-0.0	-1.3	1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.8	-0.2	-0.0	0.9	0.5	0.4	-1.0	-0.0	-1.4	-0.2	-1.1	-0.9
High blood pressure	0.3	1.0	6.7	-0.6	-1.2	-1.0	-0.2	-2.6	-0.1	-0.5	0.1	-0.9	-0.4	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	0.3	-0.2	-1.2	-0.2	-1.3	-0.0	0.3	0.1	0.1	0.0	1.3
Multivitamins +/- minerals	0.6	0.8	2.5	0.8	1.6	1.5	-0.1	-0.2	-0.7	0.8	-1.2	0.3	-0.0	0.6
Stomach or abdominal pain in last month	0.7	0.9	4.3	-0.2	-0.4	-0.4	-0.8	-2.1	0.4	-0.2	-1.9	-0.1	0.3	0.7
Supplements: Glucosamine	1.2	1.5	4.7	-0.5	1.0	-1.2	-0.7	-0.9	1.3	-0.6	0.1	1.9	1.5	2.2
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	9.0	-2.1	-0.3	-1.2	-2.1	-3.0	2.0	-2.2	1.6	0.9	1.8	-0.4
Medication: Atenolol	0.6	0.8	1.7	1.3	1.1	-0.1	1.0	0.9	-0.9	1.3	0.0	0.0	-0.6	1.1
Medication: Levothyroxine sodium	1.7	2.9	7.7	1.0	0.0	2.4	0.9	2.0	-1.7	1.1	1.1	-2.8	-1.5	-2.1
Sitting height	0.1	0.7	3.5	-0.2	-0.2	0.4	0.3	-1.7	-0.2	-0.2	-0.0	-1.9	-0.5	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.0	-0.8	1.2	0.0	0.8	-0.4	0.1	-0.7	-1.1	-0.3	-1.4
High blood pressure (mother)	0.8	1.1	4.0	1.1	2.0	0.9	-0.1	1.3	-1.2	1.1	-0.6	-0.6	-0.9	0.4
Body mass index (BMI)	1.8	7.7	16.7	3.6	2.0	0.9	3.4	1.2	-4.1	3.7	0.1	-2.8	-3.9	0.9
Impedance of leg (left)	0.4	1.9	6.6	-0.7	1.5	-0.0	-0.9	0.2	1.9	-0.9	0.8	2.6	2.1	1.2
Leg predicted mass (left)	0.6	2.9	8.2	1.8	0.8	1.1	1.9	0.7	-2.4	1.9	0.5	-2.9	-2.3	-0.4
Trunk fat mass	1.7	7.2	13.9	3.4	2.3	1.1	3.6	1.4	-3.7	3.5	1.0	-2.7	-3.3	1.0
Waist circumference	2.8	10.2	18.8	4.3	3.5	1.7	4.1	2.0	-4.1	4.3	1.1	-2.1	-3.5	2.1
Number of incorrect matches in round	0.3	0.5	3.3	-0.1	-0.7	-1.8	-0.1	-0.6	0.2	-0.2	0.6	0.8	-0.4	0.0
Past tobacco smoking	0.6	1.1	3.8	-1.2	-1.9	-0.2	-0.6	-1.1	1.4	-1.2	-0.9	0.7	0.8	-0.5
Alcohol usually taken with meals	2.9	4.7	10.5	-3.0	-1.9	-1.9	-3.2	-1.6	2.8	-2.9	0.9	0.9	1.9	-0.9
Nervous feelings	0.4	0.8	1.9	-0.8	0.3	0.6	-0.6	-0.3	1.1	-0.9	1.4	1.3	1.1	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.2	-1.4	-1.1	-0.4	-0.8	-0.9	0.6	-1.3	1.8	-0.3	0.3	-1.2
Hearing difficulty/problems with background noise	0.2	0.4	2.1	0.1	1.4	0.2	-0.8	0.1	-0.5	0.2	0.0	-1.1	0.2	0.2
Hair/balding pattern: Pattern 2	1.9	2.4	9.2	-0.9	-1.5	-1.8	-1.1	-3.0	0.1	-0.8	-0.7	-1.9	-0.1	-2.1
Had menopause	0.4	0.5	3.2	0.2	0.1	-1.2	0.2	-0.5	0.3	0.1	1.8	0.1	-0.2	-0.3
Had other major operations	0.5	0.6	2.6	0.4	1.6	0.1	-0.3	-1.5	0.2	0.4	0.3	0.3	0.3	1.1
Forced vital capacity (FVC)	0.5	1.7	5.7	0.9	0.6	1.1	1.0	1.5	-1.5	1.1	-0.8	-2.4	-1.5	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	8.1	-1.5	-1.9	0.6	-2.2	-2.9	1.6	-1.5	0.0	-0.8	0.8	-1.7
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	5.7	0.3	-0.3	2.4	0.5	1.4	-0.6	0.3	1.1	-0.2	0.1	-0.7
Qualifications: None of the above	0.8	1.7	4.0	1.3	0.5	2.0	0.8	1.2	-1.6	1.3	-0.3	-1.6	-1.5	-1.1
Financial difficulties in last 2 years	0.5	0.6	2.0	0.7	1.1	0.8	0.0	-1.4	-0.4	0.6	-1.2	-0.2	-0.4	0.4
Mouth/teeth dental problems	0.2	0.3	0.9	-0.6	-0.4	0.1	0.0	0.2	0.8	-0.6	0.2	1.0	0.1	0.6
Heart attack	0.5	0.6	2.0	0.8	0.2	-0.2	0.9	1.1	-0.9	0.8	1.4	0.8	-0.4	0.0
Allergy	0.4	0.9	2.6	-1.4	-0.2	-0.2	-0.9	-0.3	1.6	-1.4	-0.4	0.3	1.3	-0.8
Pain all over the body in last month	0.7	0.8	1.7	1.1	0.7	1.3	0.6	0.8	-0.8	1.1	0.4	-0.3	-0.7	1.0
Diabetes (self-reported)	1.4	2.1	4.2	1.4	2.0	1.6	1.6	1.8	-1.7	1.4	-0.5	-0.5	-1.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	3.1	0.1	0.0	-0.7	0.4	-1.7	0.3	0.1	1.8	0.3	0.1	0.5
Medication: Ramipril	1.3	1.7	3.7	-1.3	-1.4	1.0	-1.6	-0.6	1.4	-1.4	0.7	1.5	1.9	0.7
Medication: Simvastatin	1.0	1.4	3.5	1.3	1.5	0.7	1.4	0.8	-1.9	1.3	-0.0	-1.3	-1.3	0.4
Fluid intelligence score	2.4	4.9	9.5	-2.8	-1.9	-1.8	-3.1	-2.8	2.5	-2.8	-0.9	0.3	2.3	-1.4
Illnesses of siblings	1.5	2.1	7.8	-1.6	-1.0	-2.8	-1.3	-0.6	1.8	-1.6	0.6	0.9	1.7	0.0
Neuroticism score	0.3	0.7	1.6	-0.9	0.1	1.1	-1.1	-0.9	0.3	-0.9	0.6	-0.8	0.4	-1.3
Weight	1.3	6.6	13.3	3.1	2.3	1.2	3.1	1.2	-3.6	3.2	0.5	-3.1	-3.4	0.4
Impedance of arm (right)	0.8	3.7	9.6	-2.4	-0.7	-0.5	-1.9	-1.5	2.7	-2.5	0.3	2.1	3.1	-0.1
Arm fat percentage (right)	1.6	6.2	13.2	3.2	1.9	0.9	3.4	0.9	-3.6	3.2	0.2	-2.2	-3.3	1.3
Trunk fat-free mass	0.3	1.7	5.6	1.2	1.3	1.7	1.1	0.6	-1.4	1.3	0.4	-2.4	-1.4	-0.5
Hip circumference	0.7	2.9	5.8	2.2	1.7	0.8	2.1	0.6	-2.4	2.2	0.5	-1.6	-2.0	1.0
Time employed in main current job	0.4	0.5	1.8	0.4	0.1	-0.5	1.3	-0.2	-0.4	0.4	0.1	1.3	-0.5	0.9
Alcohol intake versus 10 years previously	0.7	1.1	2.2	1.1	0.5	-1.3	1.2	0.5	-1.5	1.2	-0.2	-0.0	-1.2	1.4
Father’s age at death	0.7	1.0	2.9	0.4	-0.1	-1.7	1.1	-1.6	-0.1	0.4	1.4	0.2	0.2	1.3
Worrier / anxious feelings	0.6	1.1	2.4	-1.5	-1.2	0.6	-1.0	-0.7	0.9	-1.5	0.1	-0.5	1.1	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.2	1.2	0.7	0.8	1.5	-0.2	-1.1	1.1	-0.5	-0.4	-0.8	0.8
Falls in the last year	0.7	1.0	4.5	0.8	0.9	-1.4	0.2	-0.3	-0.1	0.6	-0.8	1.1	0.2	2.1
Hair/balding pattern: Pattern 3	0.6	0.9	3.3	-0.1	0.9	1.8	-0.9	1.0	0.0	-0.1	-1.7	0.4	0.5	0.3
Number of live births	2.2	3.2	6.6	1.8	0.7	2.5	2.2	0.7	-2.4	1.9	-0.6	-2.6	-1.8	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.0	0.5	-0.2	0.7	0.5	0.4	-1.0	0.6	-1.7	-1.7	-0.9	-1.0
Pulse rate	0.3	0.4	1.4	-0.6	-1.2	0.3	0.1	-1.0	0.8	-0.6	0.8	0.2	-0.4	-0.3
Happiness	0.3	0.3	1.7	-0.5	-0.7	-1.3	-0.4	-0.3	0.2	-0.5	-0.6	0.1	0.5	-0.1
Noisy workplace	2.8	3.4	5.9	2.2	1.8	2.0	2.2	1.3	-2.4	2.3	-0.6	-1.6	-2.2	0.3
Qualifications: A levels/AS levels or equivalent	2.2	4.8	9.7	-3.1	-2.7	-0.4	-2.7	-2.5	2.2	-3.0	-0.4	-0.4	1.6	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.9	-0.2	0.4	0.5	-1.0	-0.9	0.1	-0.1	-1.7	-0.5	0.9	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	2.4	0.0	0.1	-1.5	0.1	0.1	0.1	-0.0	1.2	-0.1	0.3	-0.1
Asthma	1.4	2.8	5.5	2.1	0.4	0.7	2.3	1.9	-2.3	2.2	0.4	-0.9	-2.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.3	-0.3	-1.1	-1.1	-0.3	-0.5	0.2	-0.2	-0.9	0.0	0.1	-0.2
Medication: Cholesterol lowering	2.6	4.1	7.7	2.7	1.8	1.4	2.6	1.9	-2.8	2.7	-0.2	-1.0	-2.1	1.2
Depression (self-reported)	2.0	2.4	5.0	-1.9	-0.1	-1.4	-2.0	-0.9	2.0	-1.9	0.6	1.5	2.2	-0.1
Medication: Lansoprazole	0.5	0.6	2.0	0.6	0.0	0.7	1.4	1.0	-0.6	0.5	1.2	-0.0	-0.6	0.2
Prospective memory result	0.6	0.8	3.6	-1.1	-1.9	-1.3	-0.7	0.1	0.3	-1.1	-0.2	-0.1	0.5	-0.5
Lung cancer (father)	0.8	1.0	4.0	-1.1	-0.7	-0.1	-1.2	-0.3	0.7	-1.1	-0.0	-1.3	0.5	-2.0
Illnesses of mother	2.3	2.8	5.7	-2.1	-2.1	0.3	-1.2	-2.4	2.1	-2.1	0.5	0.6	1.6	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.7	-0.5	-0.4	0.5	-0.4	-0.3	0.1	-0.4	-1.9	-1.2	0.1	-1.0
Pulse wave Arterial Stiffness index	0.8	1.0	3.6	0.2	0.9	0.3	0.8	-0.8	1.0	0.0	1.1	1.4	0.9	1.9
Impedance of arm (left)	0.7	3.2	6.9	-2.3	-1.6	-1.3	-1.7	-1.3	2.5	-2.4	0.2	1.7	2.6	-0.5
Arm fat mass (right)	1.7	6.9	14.8	3.3	2.1	1.1	3.4	1.0	-3.9	3.3	0.5	-2.7	-3.5	0.9
Trunk predicted mass	0.3	1.7	5.4	1.2	1.3	1.7	1.1	0.6	-1.3	1.2	0.4	-2.3	-1.4	-0.5
Standing height	0.1	0.7	1.6	-0.7	0.7	1.2	-0.4	0.0	0.8	-0.7	1.3	-0.7	0.9	-1.0
Length of working week for main job	1.1	1.2	5.7	-0.1	-0.0	-2.4	0.2	-1.6	0.5	-0.2	-1.6	0.7	0.3	1.1
Exposure to tobacco smoke at home	1.0	1.1	7.9	0.2	0.7	-0.1	-0.5	1.6	0.0	0.2	0.2	2.8	0.8	0.7
Breastfed as a baby	2.7	3.3	9.5	-0.8	-1.2	-0.7	0.1	-2.0	2.4	-1.0	0.1	3.1	2.5	2.8
Tense / ‘highly strung’	0.4	0.7	3.5	-0.0	0.7	1.9	-0.3	-0.6	-0.7	0.1	0.1	-0.8	-0.8	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.0	-1.3	-0.0	-0.6	-1.7	-0.2	0.8	-1.3	1.4	-0.1	1.1	-1.0
Hair/balding pattern: Pattern 4	1.0	2.3	5.1	1.9	1.4	1.5	2.3	1.2	-1.4	1.9	1.4	0.3	-0.9	1.7
Birth weight of first child	1.1	2.0	9.4	-0.8	-1.7	-3.1	-0.8	-0.7	0.0	-0.8	-2.5	-1.1	0.1	-0.6
Peak expiratory flow (PEF)	0.3	0.6	1.6	1.1	-0.0	0.9	0.9	1.3	-0.6	1.1	-0.4	-0.1	-0.5	0.5
Pulse wave reflection index	1.4	1.7	5.1	1.7	2.3	0.8	1.3	-0.0	-1.1	1.7	-0.7	0.5	-0.2	1.9
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	-0.5	-1.2	-0.2	-0.2	-0.8	0.9	-0.5	1.2	0.5	1.4	1.3
Loud music exposure frequency	0.4	0.4	1.6	1.0	0.4	0.5	1.2	0.1	-0.3	0.9	-0.1	-0.0	-0.4	0.6
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	8.2	-2.3	-2.0	-2.9	-1.6	-0.9	2.4	-2.4	0.3	2.2	2.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.9	0.1	-0.6	-0.9	-0.7	0.2	-0.8	0.2	-0.4	-2.0	-0.7	-1.7
Blood clot in the leg (DVT)	0.3	0.4	2.1	-0.7	-1.4	0.1	-0.6	-0.3	0.0	-0.7	0.7	-0.1	0.4	-0.6
Medication: Paracetamol	0.7	1.2	5.1	-0.4	-1.5	0.2	-0.4	-0.9	-0.7	-0.3	-2.3	-1.1	-0.7	-1.5
Headache pain in last month	0.5	0.9	2.2	-0.7	0.3	-0.8	-1.1	-1.0	1.1	-0.8	-1.5	0.6	0.9	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.4	-1.1	-0.3	0.5	-1.2	-0.1	1.6	-1.1	0.7	0.7	1.1	-0.6
Glaucoma (self-reported)	0.3	0.4	1.5	0.2	-0.2	0.8	0.1	0.8	-0.9	0.3	-1.2	-0.4	-0.3	-0.2
Gout (self-reported)	0.3	0.4	2.2	-0.4	-1.5	-0.1	-0.4	-0.5	0.6	-0.5	-0.1	-0.8	0.7	-0.2
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	8.3	1.1	-0.4	2.3	0.7	1.4	-1.3	1.2	0.5	-2.9	-1.4	-2.1
Medication: Amlodipine	1.4	2.0	5.3	1.3	0.3	0.7	1.1	2.0	-2.3	1.5	0.7	-1.1	-1.9	-0.9
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.1	1.4	0.5	1.8	1.5	1.4	-1.3	1.4	0.2	0.3	-0.8	0.9
Birth weight	0.4	0.8	2.5	-0.7	0.4	-1.2	-1.4	0.4	0.3	-0.7	0.2	-0.8	0.7	-1.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	0.4	1.0	0.3	-0.1	1.2	-0.7	0.4	-0.7	-0.2	-0.3	-0.2
High blood pressure (siblings)	1.6	2.4	7.7	1.3	0.9	2.8	0.7	1.7	-2.0	1.4	-0.2	-1.4	-1.9	-1.2
Forced vital capacity (FVC), Best measure	0.2	0.6	2.4	-0.2	0.4	1.0	-0.0	0.7	-0.2	-0.1	-0.9	-1.5	-0.1	-1.3
Body fat percentage	1.8	7.2	13.6	3.5	2.4	0.7	3.7	1.4	-3.7	3.6	0.9	-2.2	-3.4	1.4
Leg fat percentage (right)	1.9	6.8	13.1	3.4	2.5	0.5	3.5	0.7	-3.5	3.4	0.7	-2.1	-3.6	1.4
Arm fat-free mass (right)	0.7	3.4	6.6	2.2	1.6	1.4	2.0	1.4	-2.3	2.2	0.5	-2.6	-2.3	0.2
Exposure to tobacco smoke outside home	0.7	0.9	3.0	-0.2	-0.4	-0.5	-0.8	-1.5	-0.6	-0.1	-0.8	-1.7	-0.8	-1.4
Comparative body size at age 10	0.8	2.3	8.2	-2.0	-1.5	-1.2	-2.9	-0.3	1.2	-1.9	-0.4	0.9	1.4	-1.0
Number of full brothers	0.6	0.7	2.0	0.7	0.2	-0.0	1.0	-1.1	-1.0	0.7	-0.2	-1.4	-1.2	-0.5
Worry too long after embarrassment	0.6	1.1	2.8	-1.1	-0.6	-1.7	-1.4	-1.2	1.3	-1.1	-0.6	0.3	0.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.5	-1.2	-0.9	0.3	-1.4	-1.3	0.2	-1.1	0.6	-0.6	0.0	-1.9
Wheeze or whistling in the chest in last year	1.5	2.8	6.4	2.1	1.7	0.9	1.8	-0.0	-2.5	2.2	0.0	-1.4	-2.4	-0.0
Number of children fathered	0.5	0.5	1.0	-0.5	-0.9	-0.3	-0.6	-0.9	1.0	-0.7	0.0	-0.9	0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	5.1	5.9	11.4	2.5	2.6	2.8	2.5	3.4	-3.1	2.6	-1.3	-1.3	-2.6	0.2
Age at first live birth	0.3	0.6	2.5	0.4	-0.5	1.6	0.6	-1.4	0.0	0.4	-0.7	-0.1	-0.2	0.3
Pulse wave peak to peak time	0.8	0.9	3.9	-0.5	-1.1	-0.5	-1.1	0.6	-0.6	-0.4	-0.7	-1.2	-0.7	-2.0
Health satisfaction	1.2	1.6	4.8	1.5	0.6	-0.9	2.2	0.9	-0.9	1.4	-0.8	0.0	-1.0	2.1
Shortness of breath walking on level ground	0.3	0.4	1.6	-0.4	-0.7	-0.6	-0.4	-0.2	-0.2	-0.4	1.3	-0.5	0.2	-1.1
Qualifications: College or University degree	0.5	1.5	4.6	-1.5	-2.1	-0.4	-1.4	-1.2	1.2	-1.4	-0.6	-0.2	1.0	-1.1
Eye problems/disorders: None of the above	1.5	1.7	5.0	-1.1	-2.0	-1.4	-0.7	-2.2	1.7	-1.2	-0.4	0.8	1.0	0.4
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.8	1.6	1.1	1.4	1.1	1.2	-1.6	1.7	0.4	-0.9	-1.7	-0.4
Emphysema/chronic bronchitis	0.6	0.7	2.2	0.0	-0.6	-1.1	-0.1	-0.6	-0.6	0.1	1.2	-0.2	-1.3	-1.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	-0.2	0.7	-1.3	-0.2	0.3	1.0	-0.3	0.2	0.4	0.8	0.9
Neck or shoulder pain in last month	2.8	3.9	5.9	2.1	2.1	2.4	1.7	2.2	-2.1	2.2	-2.3	-1.5	-1.9	0.7
Medication: Blood pressure	0.3	0.5	2.5	-0.5	-0.9	-1.6	-0.3	-1.1	-0.3	-0.4	-0.8	-0.2	-0.1	-0.2
Angina (self-reported)	0.9	1.2	7.3	1.0	1.4	2.7	0.4	0.7	-1.0	1.0	0.7	0.0	-0.7	0.2
Migraine (self-reported)	0.6	0.7	2.0	1.0	1.3	-0.1	0.7	1.1	-0.4	0.9	0.4	0.6	-0.1	1.4
Medication: Ibuprofen	0.2	0.3	1.2	0.5	-0.1	-0.7	0.3	0.5	-0.3	0.6	-1.1	0.0	-0.4	0.5
Medication: Allopurinol	0.5	0.6	3.6	-0.5	-1.9	-0.3	-0.3	-0.3	0.6	-0.6	-0.4	-1.2	0.1	-0.7
Medication: Omeprazole	0.6	0.7	4.3	-0.5	-0.2	2.1	-0.6	0.8	-0.3	-0.3	0.5	-0.8	0.2	-1.2
Medication: Seretide 50 evohaler	0.7	0.8	1.5	1.2	0.1	0.4	1.2	1.2	-0.9	1.2	-1.1	0.1	-0.6	0.2
Mean time to correctly identify matches	0.5	0.9	2.4	0.8	1.5	1.5	0.5	1.4	-1.2	0.9	-0.1	0.3	-0.5	0.3
Heart disease (mother)	1.6	1.9	4.9	1.6	0.8	0.3	1.6	1.4	-2.2	1.7	-0.3	-1.6	-1.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.1	0.4	0.2	-0.9	-0.1	0.8	-0.4	0.5	-1.4	0.2	-0.5	0.3
Whole body fat mass	1.9	7.8	15.1	3.6	2.5	1.1	3.7	1.4	-3.9	3.6	0.8	-2.5	-3.6	1.2
Leg fat mass (right)	2.3	8.8	16.4	3.8	3.0	1.1	3.8	1.4	-4.0	3.9	0.6	-2.4	-3.9	1.5
Arm predicted mass (right)	0.7	3.8	6.6	2.3	1.9	1.6	2.0	1.6	-2.5	2.4	0.3	-2.6	-2.4	0.1
Pulse rate, automated reading	0.4	1.2	4.7	0.7	1.0	0.1	1.0	-2.0	0.2	0.5	0.4	1.4	0.2	2.2
Alcohol intake frequency.	0.4	1.0	3.4	0.6	-0.0	0.4	1.2	0.8	-1.5	0.7	-0.1	-1.4	-1.8	-0.6
Comparative height size at age 10	0.2	0.9	3.1	-0.0	1.4	0.7	0.5	1.8	-0.3	0.0	1.7	-0.7	-0.1	-0.6
Number of full sisters	1.9	2.4	8.4	-2.2	-0.6	-0.4	-2.9	-1.2	1.4	-2.2	0.2	-0.4	1.7	-1.1
Suffer from ‘nerves’	0.1	0.1	0.4	-0.6	0.0	-0.6	-0.3	-0.2	0.1	-0.6	0.3	-0.1	-0.0	-0.2
Overall health rating	2.1	4.5	9.9	2.6	1.6	1.4	2.6	1.2	-3.1	2.7	0.1	-2.0	-2.9	0.3
Chest pain or discomfort	0.2	0.4	1.4	-0.2	-0.4	-1.2	-0.3	-1.1	0.3	-0.3	0.2	-0.7	-0.4	-0.2
Had major operations	0.5	0.6	2.3	0.8	0.5	0.3	0.9	0.0	-1.3	0.9	0.3	-0.5	-1.5	-0.0
Age at last live birth	0.9	1.3	4.2	1.1	-0.5	2.0	1.2	-1.2	-0.8	1.1	-0.6	-1.4	-1.2	-0.6
Family relationship satisfaction	1.2	1.5	2.9	-1.2	-1.7	-1.5	-1.4	-1.2	1.2	-1.2	-0.0	1.1	1.4	0.4
Leg pain on walking	0.3	0.3	1.4	0.5	1.2	0.8	0.7	0.1	-0.4	0.5	0.1	-0.3	-0.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.0	1.1	0.8	-0.3	0.7	1.0	-1.4	1.3	-1.1	0.4	-1.0	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.2	-0.2	-0.2	0.8	-0.9	0.3	-0.2	-1.0	-0.5	-0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	-0.7	-0.4	-0.9	-0.9	0.4	1.0	-0.7	1.0	-0.2	0.8	-0.1
Medication: Aspirin	0.3	0.4	1.7	-0.8	-0.4	0.1	-0.5	-0.8	-0.2	-0.7	0.7	-0.3	-0.1	-1.3
Supplements: Vitamin C	0.6	0.7	2.4	-0.4	1.1	0.3	-1.5	0.4	-0.0	-0.3	-1.4	-0.7	-0.2	-1.1
Knee pain experienced in last month	0.6	1.0	2.1	1.5	1.3	0.5	0.6	0.3	-1.2	1.5	-0.4	-0.5	-0.9	1.1
Hypertension (Self-reported)	0.3	0.9	5.7	-0.4	-1.1	-0.9	-0.2	-2.4	-0.3	-0.3	-0.1	-1.1	-0.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	2.0	0.4	0.7	1.4	0.6	0.6	-0.1	0.3	0.9	0.3	0.2	0.8
Illnesses of father: Heart disease	1.5	2.1	5.1	1.7	1.4	1.0	2.2	0.6	-2.1	1.8	0.4	-0.3	-1.9	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.9	0.6	0.4	1.4	0.5	-0.1	-0.6	0.6	-1.2	-0.5	-0.8	-0.6
Smoking status: Previous	0.8	1.3	2.4	1.5	1.3	-0.1	0.9	1.4	-1.5	1.5	0.5	-1.0	-1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.8	0.1	0.8	-0.3	-0.1	1.7	0.1	0.1	0.5	0.3	0.7	0.6
Whole body fat-free mass	0.4	2.3	6.8	1.5	1.2	1.5	1.5	0.8	-1.8	1.6	0.4	-2.6	-1.8	-0.4
Leg fat-free mass (right)	0.5	2.5	6.6	1.7	0.8	1.1	1.7	0.9	-2.2	1.8	0.5	-2.6	-2.1	-0.4
Arm fat percentage (left)	1.5	6.0	12.9	3.2	1.5	0.4	3.4	1.0	-3.6	3.2	0.1	-2.4	-3.4	1.1
Average weekly red wine intake	1.9	2.8	6.9	-2.1	-2.6	-1.1	-1.8	-1.8	1.7	-2.0	1.4	-0.1	1.1	-1.6
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.4	0.9	1.2	-0.3	0.3	1.5	-0.8	0.9	-0.7	0.1	-1.3	-0.0
Mood swings	0.4	0.8	3.5	-1.0	-0.0	1.1	-0.7	-0.3	0.4	-1.0	1.9	-0.4	0.7	-0.6
Loneliness, isolation	0.2	0.3	0.7	-0.0	-0.3	-0.7	0.5	-0.4	-0.2	-0.0	0.8	-0.7	-0.6	-0.7
Long-standing illness, disability or infirmity	0.7	1.0	3.9	0.7	1.7	2.0	0.0	0.7	-0.3	0.6	0.2	1.0	0.1	1.4
Ever had bowel cancer screening	0.3	0.3	1.1	0.5	1.1	0.2	0.5	-0.4	-0.7	0.5	0.4	-1.0	-0.1	-0.3
Diabetes diagnosed by doctor	1.8	3.0	6.6	1.7	2.0	2.1	1.5	2.6	-2.1	1.8	-0.2	-1.0	-1.9	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.4	-0.1	1.1	0.2	-0.9	-1.2	-0.0	-0.1	-0.2	0.6	0.3	1.1
Friendships satisfaction	1.9	2.4	7.5	-1.8	-2.0	-2.7	-1.8	-1.4	1.4	-1.8	-0.6	0.1	0.8	-0.5
Qualifications: nursing, teaching	1.6	2.6	5.4	-2.3	-1.5	-1.1	-1.3	-2.3	1.9	-2.3	-0.5	0.3	1.5	-1.2
Commuting to job workplace: Walk	1.5	1.6	4.9	-1.6	-1.7	0.3	-1.3	0.4	0.1	-1.5	1.5	-0.4	0.7	-2.2
Eye problems/disorders: Cataract	2.9	3.4	10.8	1.5	2.2	3.3	0.9	3.1	-1.6	1.5	1.7	-0.5	-0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.2	-1.0	0.5	1.0	-1.8	-1.6	0.4	-0.9	-1.3	0.4	1.1	-0.7
Medication for cholesterol	0.3	0.5	1.2	-0.4	-0.3	-0.7	-0.8	0.6	0.8	-0.5	-0.9	1.1	0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	9.2	1.4	0.8	2.0	0.5	-0.4	-2.0	1.5	-0.9	-3.0	-2.3	-1.8
Back pain experienced in last month	0.3	0.5	1.9	-0.0	0.0	-1.4	0.3	-0.9	0.1	-0.0	-1.1	0.2	-0.3	1.1
Mineral and other dietary supplements	0.5	0.7	2.1	-0.9	-1.4	0.9	-0.4	-0.0	0.6	-0.9	-0.2	-0.3	0.6	-1.4
Breast cancer (self-reported)	0.5	0.6	1.9	0.4	1.3	1.4	0.5	1.0	-0.3	0.4	1.3	-0.2	-0.2	0.3
Asthma (self-reported)	1.2	2.3	4.6	2.0	0.4	0.7	2.2	1.8	-2.1	2.0	0.5	-0.7	-2.0	0.1
Osteoporosis (self-reported)	1.0	1.2	2.2	-1.4	-1.4	-1.3	-0.9	0.6	1.5	-1.4	0.4	1.0	1.1	-0.3
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.3	1.2	-1.1	-0.0	-0.2	-0.6	0.3	-0.5	-0.9	-0.9	0.1
Medication: Aspirin	0.4	0.5	2.3	-0.9	-0.5	-0.1	-0.5	-0.6	-0.4	-0.8	0.5	-0.6	-0.2	-1.5
Medication: Gliclazide	1.0	1.2	3.0	1.1	1.4	1.7	0.6	1.3	-1.0	1.1	-0.2	-1.3	-0.9	-0.1
Illnesses of father: None of the above (group 1)	0.9	1.2	4.3	-1.0	-0.3	-2.1	-1.3	-0.3	1.2	-1.1	-0.5	1.0	1.3	-0.2
Smoking status: Current	0.4	0.6	3.6	-0.3	1.2	0.0	-0.4	0.1	0.3	-0.3	1.9	1.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	11.1	0.7	-0.6	0.3	0.5	0.0	-0.3	0.7	-3.3	-0.4	-0.5	0.5
Whole body water mass	0.5	2.6	7.1	1.6	1.3	1.5	1.6	1.0	-2.0	1.8	0.4	-2.7	-2.0	-0.4
Leg predicted mass (right)	0.5	2.5	6.5	1.7	0.8	1.1	1.7	0.9	-2.2	1.8	0.5	-2.5	-2.1	-0.4
Arm fat mass (left)	1.8	7.4	15.4	3.5	2.1	1.0	3.6	1.1	-3.9	3.5	0.6	-2.8	-3.6	1.0
Number of self-reported non-cancer illnesses	1.0	1.7	4.1	1.5	0.6	0.4	1.8	-0.1	-1.6	1.5	1.2	-1.6	-2.0	0.1
Average weekly champagne plus white wine intake	1.0	1.3	4.0	-1.1	-0.8	-2.0	-1.5	-0.7	1.3	-1.1	-1.4	-0.4	0.7	-0.9
Miserableness	2.0	3.4	8.8	-1.7	-0.4	-0.7	-2.2	-1.1	2.5	-1.9	1.4	2.6	3.0	0.9
Guilty feelings	0.1	0.2	1.3	-0.2	0.4	-1.1	-0.5	-0.1	0.0	-0.2	-0.4	-0.3	-0.2	0.5
Wears glasses or contact lenses	0.5	0.5	1.3	0.6	0.8	1.1	1.0	1.1	-0.5	0.6	0.3	-0.2	-0.3	0.8
Ever taken oral contraceptive pill	0.3	0.4	1.4	0.2	-0.5	-0.6	0.1	1.0	0.6	0.1	-0.3	0.5	0.6	1.2
Hearing aid user	0.4	0.4	3.2	-0.1	1.8	0.8	-0.6	-0.1	0.1	-0.1	0.5	-0.1	0.6	-0.3
Mother’s age at death	2.0	2.5	5.5	-1.8	-0.5	-1.2	-2.3	-1.7	2.1	-1.8	0.0	1.4	2.2	-0.4
Financial situation satisfaction	0.5	0.6	2.5	-0.4	-0.7	-1.6	-1.4	-1.0	0.5	-0.4	-0.1	0.0	0.5	0.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	3.6	0.8	0.1	1.9	0.5	-0.1	-0.8	0.8	0.3	-0.2	-0.8	-0.5
Commuting to job workplace: Public transport	1.6	1.9	5.6	-1.8	-1.5	-0.8	-2.4	0.3	0.1	-1.5	-0.9	-1.0	0.7	-2.1
Eye problems/disorders: Glaucoma	0.5	0.6	2.3	0.0	-0.1	0.5	-0.2	0.5	-0.7	0.2	-1.5	-1.3	-0.4	-1.1
Medication: Blood pressure	0.2	0.4	1.3	0.6	0.5	1.0	0.3	-0.3	-0.8	0.6	1.1	0.1	0.0	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.8	0.0	-0.4	-0.8	-0.1	0.3	-0.3	0.0	-0.2	-1.4	-0.7	-1.3
Supplements: Fish oil (including cod liver oil)	1.9	2.5	5.2	2.2	2.3	-0.2	1.8	0.9	-1.6	2.2	-0.2	-0.3	-1.5	1.9
High cholesterol (Self-reported)	1.2	2.1	4.5	1.9	0.3	-0.3	1.9	0.9	-2.1	1.9	-0.2	-1.3	-2.1	0.3
Medication: Bendroflumethiazide	0.1	0.2	1.0	0.3	1.0	0.1	-0.2	0.3	-0.1	0.3	0.4	-0.4	0.1	0.3
Medication: Paracetamol	0.6	1.0	3.4	-0.2	-1.1	0.8	-0.2	-0.5	-0.9	-0.1	-1.8	-1.2	-1.0	-1.3
Medication: Lisinopril	0.9	1.1	3.1	0.3	-0.7	-1.1	0.9	0.0	-1.8	0.5	0.2	-1.5	-1.5	-1.5
Medication: Atorvastatin	0.4	0.5	1.3	-0.9	-0.8	-0.4	-0.7	-0.4	0.6	-0.9	0.5	1.1	0.2	-0.9
Illnesses of father: High blood pressure	0.5	0.6	2.5	-0.0	-0.4	0.4	0.3	-0.7	-0.9	0.1	-0.1	-1.6	-1.0	-1.1
Alcohol drinker status: Never	0.2	0.2	0.8	0.4	0.6	-0.1	0.9	0.2	-0.3	0.4	-0.6	0.1	-0.8	0.3
Ever smoked	0.1	0.2	1.4	-0.2	1.2	-0.5	-0.4	-0.2	0.0	-0.2	0.6	0.1	0.4	0.3
Basal metabolic rate	0.7	3.6	8.0	2.1	1.6	1.6	2.1	1.0	-2.5	2.2	0.5	-2.8	-2.4	-0.2
Leg fat percentage (left)	1.9	7.0	12.7	3.6	2.7	0.6	3.5	1.1	-3.5	3.5	0.8	-1.8	-3.5	1.5
Arm fat-free mass (left)	0.7	3.5	6.9	2.1	1.9	1.5	1.9	1.1	-2.4	2.2	0.7	-2.6	-2.4	-0.0
Number of operations (self-reported)	0.3	0.4	0.6	0.7	0.6	0.6	0.6	-0.8	-0.5	0.6	0.7	-0.5	-0.8	0.2
Average weekly beer plus cider intake	0.4	0.6	2.1	0.6	0.5	0.2	0.4	0.6	-1.1	0.6	-0.3	-1.4	-1.3	-0.2
Irritability	0.6	0.9	2.5	-1.1	-0.2	1.6	-0.7	-0.8	0.2	-1.0	1.1	-0.7	0.5	-1.6
Risk taking	1.4	2.0	5.9	1.9	1.2	-0.2	1.4	-0.8	-1.6	1.9	-0.8	-1.0	-2.4	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.8	-0.1	-0.5	0.5	-0.4	0.3	-0.5	-0.1	0.4	-1.0	-0.7	-1.3
Fractured/broken bones in last 5 years	2.6	3.4	6.8	2.5	2.5	-0.2	2.6	1.2	-1.6	2.3	0.4	0.3	-1.7	2.3
Age started oral contraceptive pill	0.2	0.2	0.7	0.4	0.4	-0.4	0.6	-0.4	-0.3	0.4	-0.4	-0.8	-0.8	0.0
Diastolic blood pressure, automated reading	0.4	1.1	5.9	-0.2	-0.1	-2.1	-0.3	-2.4	0.3	-0.2	0.3	0.6	0.0	1.3
Ever depressed for a whole week	0.4	0.5	2.8	0.2	-0.0	0.9	-0.1	1.3	-0.1	0.2	1.7	-0.2	-0.1	-0.7
Unable to work because of sickness or disability	0.8	1.0	4.4	-0.1	0.5	1.3	-0.6	0.7	-1.1	0.1	1.0	-1.1	-1.0	-2.1
Commuting to job workplace: Cycle	0.7	0.8	2.8	0.6	0.3	1.7	0.3	1.0	-0.7	0.6	1.5	-0.8	-0.6	-0.4
Myopia	0.3	0.4	2.1	-0.5	-0.1	1.5	-0.2	0.7	0.4	-0.5	0.5	-0.3	0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	4.2	0.1	0.9	1.3	-0.1	2.1	0.4	0.1	-0.5	0.4	0.6	-0.0
Cholesterol lowering medication	0.4	0.6	2.0	0.5	0.4	0.4	1.4	-0.1	-1.2	0.5	0.7	-0.8	-1.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.5	0.1	-0.1	1.9	0.1	1.0	-0.4	0.1	0.6	-0.0	0.3	-0.0
Pain experienced in last month	0.3	0.4	1.5	-0.2	-0.7	-0.7	0.2	0.6	0.6	-0.3	0.9	1.2	0.6	-0.1
Supplements: Calcium	0.2	0.2	0.9	-0.2	-0.1	-0.4	-0.4	0.4	-0.2	-0.1	-0.0	-1.0	-0.5	-0.6
Basal cell carcinoma (self-reported)	0.9	1.1	2.0	1.3	0.9	1.3	1.3	0.7	-1.1	1.2	-0.5	-0.1	-0.8	1.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	0.7	-0.1	-0.2	0.9	1.3	-0.9	0.7	1.4	0.6	-0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.0	-0.7	-1.4	0.1	-0.6	-0.4	-0.2	-0.6	0.6	-0.5	0.2	-0.9
Heart disease (siblings)	1.0	1.3	3.4	1.0	0.1	0.8	1.0	0.2	-1.6	1.0	-1.1	-1.7	-1.8	-0.3
Alcohol drinker status: Previous	1.8	2.0	7.5	2.0	0.8	-0.1	2.7	0.9	-1.3	1.9	0.2	-0.3	-1.6	1.3
Pack years of smoking	0.5	0.7	1.7	0.8	1.2	0.4	1.2	0.2	-1.2	0.9	0.1	-0.8	-1.3	0.0
Impedance of whole body	0.5	2.3	6.4	-1.6	-0.2	-0.6	-1.3	-0.4	2.3	-1.8	0.8	2.2	2.5	0.3
Leg fat mass (left)	2.2	8.6	15.7	3.8	3.0	1.2	3.8	1.5	-4.0	3.8	0.8	-2.3	-3.7	1.4
Arm predicted mass (left)	0.8	4.0	6.6	2.2	2.0	1.9	2.2	1.4	-2.4	2.3	0.9	-2.6	-2.5	0.1