Hub : Genes

LY6E

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.4680 0.1160 3.8e-03 0.147 NA 0.032 NA 0.110 5.3e-05 NA 4.3e-02 NA 4.6e-04
2 GTEx Cells Transformed fibroblasts 0.2120 0.0590 4.2e-06 0.090 NA 0.103 NA 0.100 3.0e-07 NA 3.8e-08 NA 6.0e-08
3 ROSMAP Brain Pre-frontal Cortex 0.0809 0.0320 8.7e-04 0.002 0.019 0.005 0.024 0.004 1.7e-01 1.5e-03 7.6e-02 3.5e-04 1.0e-01
4 YFS Blood 0.1390 0.0296 2.3e-13 0.070 0.065 0.075 0.079 0.071 5.8e-22 1.5e-20 1.6e-23 1.6e-24 2.5e-22
5 TCGA Colon Adenocarcinoma 0.1040 0.0530 7.1e-04 0.059 0.056 0.034 NA 0.041 2.7e-04 3.4e-04 4.4e-03 NA 2.1e-03
6 TCGA Thyroid Carcinoma 0.1510 0.0520 2.2e-12 0.144 0.152 0.137 NA 0.142 6.3e-14 1.2e-14 2.9e-13 NA 1.0e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 2.0 3.1 6.7 -1.1 1.2 0.2 2.0 2.3 2.6
Bipolar Disorder or Schizophrenia 1.3 3.1 6.9 -1.5 1.2 -1.3 1.0 2.6 2.3
Depressed Affect (Nagel 2018) 1.3 2.8 4.5 1.6 -1.9 -1.3 -1.1 -2.1 -1.9
Depression (Nagel 2018) 0.6 0.9 2.3 0.8 -1.3 0.0 -0.6 -1.5 -0.8
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.8 -0.8 0.6 1.0 1.3 0.2 1.4
Neuroticism (Nagel 2018) 1.8 4.3 8.1 1.9 -2.8 0.0 -0.6 -2.8 -2.5
Schizophrenia (2018) 0.6 1.2 3.4 -1.0 0.5 -1.9 -0.5 1.4 0.6
Schizophrenia vs Biploar Disorder 0.6 0.8 2.1 -0.4 -0.3 -0.6 -1.4 1.4 0.1
Worry (Nagel 2018) 2.8 5.9 10.5 2.0 -3.2 1.0 -1.1 -3.1 -2.9
Alzheimer’s Disease (in mother) 0.6 0.7 2.3 -1.5 0.4 0.0 0.1 1.2 0.6
Alzheimer’s Disease (in father) 0.4 0.4 0.8 0.0 0.6 -0.9 0.7 0.2 0.8
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 -0.7 -0.1 -0.2 0.6 0.5 0.2
Crohns Disease (2017) 0.3 0.6 3.0 0.3 -0.4 -0.3 0.1 1.7 0.5
Irritable Bowel Disease (IBD) 0.3 0.6 1.7 -0.3 -0.1 -1.2 0.4 1.3 0.7
Ulcerative Colitis (UC) 0.7 1.3 2.8 -1.4 0.9 -1.7 0.5 0.5 1.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.8 1.5 6.3 -1.3 0.7 -2.5 0.1 -0.3 0.6
Verbal and Numeric Reasoning (VNR) 0.9 2.3 5.0 -1.5 0.3 2.2 0.8 1.6 1.7
Breast Cancer 0.4 1.0 2.2 -0.8 1.5 0.5 0.4 1.1 1.3
Ovarian Cancer 0.6 0.8 1.5 1.0 -1.0 1.2 0.3 -0.2 -1.1
Prostate Cancer 0.4 0.5 2.7 0.1 0.0 -0.2 0.2 1.7 0.4
Age at First Birth 1.2 1.7 3.5 1.0 -1.6 1.9 -0.4 1.4 -1.1
Bipolar Disorder (2011) 1.0 1.0 3.3 -1.8 0.0 0.0 -0.2 1.7 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 0.0 -0.4 -0.3 -0.5 0.1 -0.5
Coronary Artery Disease (CAD) 2.1 2.6 7.4 -1.6 1.5 0.1 0.8 1.6 2.7
Crohns Disease (2012) 0.2 0.4 1.3 -0.4 0.6 -0.3 -0.2 0.5 1.1
Mean Putamen Volume 0.1 0.1 0.3 -0.6 -0.1 -0.4 -0.2 0.2 0.1
Fasting Glucose 1.1 1.3 3.6 1.9 -1.0 1.6 0.7 0.7 -0.2
HbA1C 0.4 0.4 0.9 0.9 -0.9 -0.6 0.8 0.1 -0.2
HDL Cholesterol 1.1 1.8 3.8 1.4 -2.0 1.9 -0.0 1.1 -0.8
LDL Cholesterol 0.1 0.1 0.3 0.4 0.2 -0.3 -0.2 -0.5 -0.1
Lupus 1.7 2.5 4.8 -1.6 1.4 -2.2 -1.1 1.7 1.2
Neuroticism (2016) 2.0 2.9 8.0 0.7 -1.4 0.3 -1.9 -2.8 -1.8
Primary Biliary Cirrhosis 0.8 1.1 4.6 -0.2 0.2 -2.1 -1.4 -0.3 0.0
Rheumatoid Arthritis 1.8 2.4 6.4 1.8 -1.1 -0.3 -0.9 -1.7 -2.5
Schizophrenia (2014) 1.8 4.1 7.3 -2.1 1.7 -2.1 -0.7 2.7 2.2
Triglycerides 0.8 1.4 3.9 0.3 -0.2 -2.0 0.7 -1.9 -0.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 1.1 -0.1 -0.5 0.4 0.2 1.1 0.2
Ulcerative Colitis 0.8 1.1 2.9 -0.9 1.3 -1.7 -0.3 0.2 1.1
Blood Eosinophil Count 0.4 3.0 13.7 -1.1 1.0 -3.7 0.4 0.5 1.2
Blood Platelet Count 0.2 2.9 4.2 1.7 -2.0 2.0 1.1 -0.9 -2.0
Blood Red Count 0.1 1.1 4.4 0.6 -0.7 2.1 -0.3 -1.1 -0.5
Blood White Count 0.0 0.3 0.6 -0.7 0.3 -0.4 0.5 -0.7 -0.3
Heel T-Score 2.1 16.5 27.9 -5.3 5.0 -2.0 1.5 3.8 5.1
BMI 0.4 2.3 7.3 -1.3 1.8 -2.7 -0.7 -1.1 0.4
Height 0.5 10.4 26.5 3.1 -4.6 0.4 5.2 0.8 -2.2
Waist Hip Ratio (WHR) 0.7 2.9 6.0 2.5 -2.3 -0.2 -0.7 -1.2 -2.0
Systolic Blood Pressure 1.9 9.3 21.1 -3.9 4.6 -2.1 -3.0 -0.3 2.5
Smoking Status 0.5 1.1 3.0 1.2 -1.7 0.5 0.9 0.6 -1.1
Allergy or Eczema 0.1 0.2 0.7 -0.3 0.2 -0.2 0.2 0.7 0.8
Cardiovascular Disease 1.9 6.4 11.7 -3.3 3.4 -3.2 -0.5 0.3 2.3
Hypothyroidism (self reported) 0.3 0.7 2.4 0.2 -0.7 1.6 0.1 -0.6 -1.1
Respiratory disease 0.6 1.4 2.6 -1.3 1.1 -1.6 -1.5 -0.5 0.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 -1.0 0.3 0.8 0.2 0.5 0.7
Lung FEV1/FVC ratio 0.4 2.2 5.8 -0.2 1.0 -2.4 1.9 0.5 1.5
Lung FVC 0.2 1.0 3.7 -0.9 1.9 -0.8 -0.4 0.4 0.6
Neuroticism 2.1 5.1 8.9 2.1 -2.3 -0.7 -2.3 -3.0 -2.5
Chronotype (morning person) 0.1 0.1 0.5 -0.2 -0.0 -0.5 -0.0 -0.7 -0.3
Hair Pigment 0.0 1.1 2.0 -0.9 1.1 -1.4 -1.4 0.0 0.9
Tanning 0.1 1.4 3.7 0.9 -1.3 1.9 -0.4 -0.0 -1.4
Hand grip strength (left) 0.5 1.2 4.8 0.6 -0.3 0.9 -2.2 -0.6 -0.9
Number of treatments/medications taken 0.4 0.7 1.9 0.4 -0.6 -1.4 0.9 -0.9 -0.5
Average weekly spirits intake 0.4 0.5 1.7 -0.3 -0.4 -0.8 1.3 0.1 0.8
Sensitivity / hurt feelings 0.6 1.0 2.0 0.7 -1.4 -0.4 -0.4 -1.2 -1.3
Frequency of depressed mood in last 2 weeks 1.1 1.5 4.0 -0.1 -0.3 -2.0 -1.4 -1.7 -0.5
Hearing difficulty/problems: Yes 1.4 2.1 3.6 -1.7 1.7 -1.9 -0.4 -1.6 0.8
Relative age of first facial hair 0.2 0.4 1.3 -0.4 0.7 0.7 -1.2 0.1 0.1
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 4.9 -2.2 2.1 0.1 0.1 0.5 1.7
Ever used hormone-replacement therapy (HRT) 2.0 2.5 4.0 1.0 -1.7 2.0 -2.0 1.2 -1.3
Ever had hysterectomy (womb removed) 0.8 0.9 3.5 -0.6 0.6 0.6 -1.9 0.7 -0.1
Systolic blood pressure, automated reading 2.5 7.3 17.6 -3.8 4.2 -1.1 -0.7 0.6 3.1
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 4.5 -1.6 0.9 -0.2 0.5 1.6 2.1
Angina 1.0 1.3 4.5 -0.2 0.3 -1.3 -2.1 -1.3 -0.2
Medication for hormone replacement therapy 0.4 0.5 1.2 0.4 -0.5 1.1 -0.7 0.1 -0.9
Vitamin and mineral supplements 0.1 0.1 0.3 0.0 0.4 0.4 0.3 0.5 0.3
Supplements: Zinc 0.3 0.3 0.5 0.4 -0.6 -0.6 0.5 0.5 -0.7
Medication: Co-codamol 0.2 0.2 1.0 0.2 1.0 -0.3 0.3 -0.4 0.3
Medication: Metformin 0.2 0.3 1.0 0.1 -0.7 0.3 -1.0 -0.2 0.0
Diabetes (father) 1.3 1.6 5.4 -0.6 0.1 2.3 1.6 1.1 0.5
Diabetes (mother) 0.8 1.0 3.5 -0.6 0.4 -1.9 0.3 -1.2 0.7
Severe depression (siblings) 0.5 0.5 1.4 1.2 -0.7 -0.6 0.3 -0.6 -0.7
Pack years adult smoking proportion 2.0 3.0 5.5 2.1 -1.6 0.0 -0.5 -2.3 -2.4
Impedance of leg (right) 1.7 8.1 12.8 3.5 -3.6 1.9 3.1 -2.0 -2.5
Leg fat-free mass (left) 0.3 1.5 3.3 -1.5 1.3 -1.8 -0.4 0.7 0.8
Trunk fat percentage 0.4 1.5 4.5 0.5 -0.4 -2.1 0.9 -1.7 -0.9
Hand grip strength (right) 0.4 1.1 1.8 1.1 -0.7 1.3 -1.1 -0.6 -1.1
Townsend deprivation index at recruitment 0.0 0.0 0.1 0.3 0.2 0.0 -0.2 0.3 -0.0
Current tobacco smoking 0.6 1.0 2.6 1.4 -1.6 -0.5 1.0 -0.1 -0.7
Average weekly fortified wine intake 1.8 2.1 6.6 0.7 -1.2 1.8 2.6 -0.5 -0.4
Maternal smoking around birth 0.4 0.6 1.2 -1.0 0.1 1.1 0.6 -0.8 0.5
Fed-up feelings 1.4 2.6 3.4 1.8 -1.7 -1.4 -1.4 -1.5 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.7 -0.2 -0.2 -0.8 -1.2 -1.9 -0.2
Relative age voice broke 1.6 2.4 5.5 1.8 -1.2 2.4 -0.3 -1.0 -1.7
Taking other prescription medications 0.7 1.1 2.4 1.2 -1.5 1.1 0.3 -0.4 -1.1
Age when periods started (menarche) 0.5 1.1 2.2 1.2 -1.5 0.7 1.3 0.9 -0.4
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 4.8 -1.4 2.0 -0.4 -2.2 0.9 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 6.4 -2.5 2.5 -1.6 0.7 0.3 2.0
Tinnitus: Yes, but not now, but have in the past 5.9 6.3 11.0 3.1 -2.4 1.8 -2.9 -0.1 -3.3
Qualifications: CSEs or equivalent 0.6 0.8 2.1 -0.9 1.4 -0.8 -0.4 0.1 1.1
Serious illness, injury or assault to yourself 0.5 0.5 0.9 -0.9 0.6 -1.0 -0.3 -0.9 0.5
High blood pressure 3.4 9.5 17.2 -4.0 3.9 -4.1 -0.4 0.4 2.9
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.5 0.0 -0.2 0.2 -0.3 1.2 0.4
Multivitamins +/- minerals 0.3 0.3 0.6 -0.6 0.1 -0.8 -0.5 0.4 0.8
Stomach or abdominal pain in last month 1.3 1.6 3.4 1.8 -1.3 0.2 -0.6 -1.1 -1.7
Supplements: Glucosamine 1.2 1.5 2.7 -1.6 1.5 -0.7 -0.8 0.9 1.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.1 0.7 -0.6 -0.7 1.5 -0.6 -0.2
Medication: Atenolol 0.5 0.6 1.5 -1.0 1.0 -1.2 0.2 0.0 0.4
Medication: Levothyroxine sodium 0.3 0.4 1.5 0.1 -0.1 0.8 0.0 -1.2 -0.7
Sitting height 0.3 1.9 7.5 0.6 -1.5 -1.0 2.7 0.2 -0.4
Chronic bronchitis/emphysema (father) 1.8 2.1 3.7 -1.6 1.5 0.6 1.4 1.9 1.5
High blood pressure (mother) 2.1 2.9 7.1 -1.9 2.7 -1.5 0.3 1.0 1.8
Body mass index (BMI) 0.4 1.8 4.1 -1.1 1.5 -2.0 -1.2 -1.1 0.5
Impedance of leg (left) 1.4 6.6 9.5 3.1 -3.0 1.4 3.0 -2.4 -2.1
Leg predicted mass (left) 0.3 1.4 3.0 -1.5 1.3 -1.7 -0.5 0.7 0.8
Trunk fat mass 0.3 1.1 4.4 0.1 -0.1 -2.1 0.9 -1.1 -0.7
Waist circumference 0.2 0.6 2.7 0.1 -0.1 -1.6 -0.3 -0.6 -0.4
Number of incorrect matches in round 1.1 1.8 2.5 1.5 -1.6 0.9 -0.9 -1.5 -1.6
Past tobacco smoking 0.3 0.5 1.8 0.6 -0.1 0.6 -0.6 -1.3 -0.4
Alcohol usually taken with meals 0.5 0.9 2.4 -1.3 0.1 0.4 0.1 1.5 1.0
Nervous feelings 1.4 2.6 4.2 1.0 -1.6 0.1 -2.0 -2.0 -2.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.2 1.1 -1.1 -0.6 0.7 -0.3 -0.7
Hearing difficulty/problems with background noise 0.7 1.1 3.3 -0.1 0.6 -1.6 -0.0 -1.8 -0.8
Hair/balding pattern: Pattern 2 0.8 1.0 2.4 -1.1 1.4 -0.6 -0.0 0.4 1.6
Had menopause 0.6 0.8 2.9 -0.6 0.1 -0.1 -0.9 1.7 0.8
Had other major operations 0.3 0.4 2.0 0.4 0.4 -1.4 -0.2 0.1 -0.2
Forced vital capacity (FVC) 0.1 0.2 0.6 -0.3 0.7 -0.5 0.3 0.5 0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.1 8.9 -3.0 2.8 -0.8 0.2 1.1 2.4
Ever unenthusiastic/disinterested for a whole week 2.5 3.0 5.7 2.4 -2.3 -0.5 -1.1 -0.7 -2.3
Qualifications: None of the above 2.0 4.3 9.5 3.1 -2.3 -0.6 -0.9 -1.6 -2.8
Financial difficulties in last 2 years 0.4 0.6 1.5 -1.2 0.9 -0.0 0.0 0.5 0.9
Mouth/teeth dental problems 0.3 0.4 2.1 -0.1 0.2 0.4 1.4 0.1 0.5
Heart attack 0.3 0.3 1.5 0.2 -0.6 -0.1 1.2 0.2 -0.2
Allergy 0.5 1.2 2.1 1.4 -1.1 0.3 1.1 -0.9 -1.4
Pain all over the body in last month 2.5 2.7 4.2 2.0 -1.7 2.0 0.1 -1.4 -1.7
Diabetes (self-reported) 0.1 0.1 0.3 -0.5 -0.1 -0.3 0.3 -0.1 0.6
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.9 -1.1 1.1 -0.5 -0.9 1.4 1.1
Medication: Ramipril 1.2 1.6 4.1 -0.4 1.1 -2.0 -1.3 -1.5 -0.3
Medication: Simvastatin 0.9 1.4 2.7 -1.0 1.4 -1.6 0.2 -0.2 1.6
Fluid intelligence score 0.7 1.5 3.0 -1.5 0.1 0.6 0.7 1.6 1.7
Illnesses of siblings 0.7 0.9 2.5 0.9 -1.6 0.3 -0.4 -1.0 -0.9
Neuroticism score 2.1 4.4 9.6 1.7 -2.2 -0.5 -1.8 -3.1 -2.3
Weight 0.1 0.7 3.4 -0.2 0.2 -1.8 0.2 -0.7 -0.3
Impedance of arm (right) 0.9 4.3 7.4 2.7 -2.5 -0.5 1.1 -1.8 -2.7
Arm fat percentage (right) 0.4 1.5 5.6 -0.2 0.6 -2.4 -0.8 -1.4 -0.7
Trunk fat-free mass 0.0 0.2 0.8 -0.4 0.1 -0.0 0.6 0.9 0.3
Hip circumference 0.4 1.6 5.2 -1.4 1.3 -2.3 0.4 -0.3 0.7
Time employed in main current job 0.7 0.8 1.7 0.8 -1.0 0.5 -0.4 -0.8 -1.3
Alcohol intake versus 10 years previously 1.4 2.1 6.6 2.6 -1.4 -0.2 -0.9 0.6 -1.6
Father’s age at death 1.1 1.5 4.1 1.1 -0.5 2.0 -1.5 0.2 -1.2
Worrier / anxious feelings 0.9 1.8 6.2 0.9 -2.5 0.1 1.3 -0.8 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 3.8 -0.9 1.1 -2.0 0.0 -0.3 1.2
Falls in the last year 0.7 0.9 2.2 -0.8 0.9 -1.5 -1.2 -0.5 -0.1
Hair/balding pattern: Pattern 3 0.2 0.3 1.0 -0.0 -0.2 -1.0 -0.1 -0.9 -0.5
Number of live births 0.8 1.1 3.5 -1.1 0.7 -1.9 0.2 0.4 1.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.1 -0.7 1.5 -1.3 -0.8 0.7 0.9
Pulse rate 0.4 0.7 1.9 1.1 -0.6 -0.4 0.6 -1.4 -0.6
Happiness 1.1 1.3 2.8 1.7 -1.5 -0.0 -0.3 -1.0 -1.3
Noisy workplace 1.3 1.6 5.3 0.2 0.6 -0.4 -2.3 -1.7 -0.8
Qualifications: A levels/AS levels or equivalent 1.8 3.9 7.1 -1.8 1.9 1.2 2.1 2.0 2.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.5 -1.3 1.2 -0.9 -0.5 0.8 1.6
Mouth/teeth dental problems: Dentures 0.2 0.3 1.0 -1.0 0.5 0.4 -0.5 0.4 0.2
Asthma 1.0 1.9 4.5 -2.1 1.7 -0.6 -0.5 0.8 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 3.0 0.5 -0.3 0.6 1.7 -0.2 0.6
Medication: Cholesterol lowering 0.8 1.2 3.3 1.0 -0.7 -1.4 -0.1 -1.8 -0.7
Depression (self-reported) 0.3 0.4 1.1 -0.5 0.1 0.9 -1.1 0.4 -0.0
Medication: Lansoprazole 0.3 0.4 1.4 0.4 -0.4 -0.7 0.3 -1.2 -0.4
Prospective memory result 1.3 1.6 3.1 1.2 -0.7 0.8 -1.2 -1.8 -1.4
Lung cancer (father) 0.3 0.4 0.8 0.9 -0.6 0.3 0.9 0.5 -0.4
Illnesses of mother 2.8 3.5 5.2 2.1 -2.3 1.6 -1.4 -1.5 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 1.4 -0.8 1.1 -1.2 -0.2 0.7 0.8
Pulse wave Arterial Stiffness index 0.7 0.9 3.4 0.0 -0.2 1.9 1.0 0.8 0.1
Impedance of arm (left) 1.1 4.9 8.9 3.0 -3.0 -0.7 1.2 -1.5 -2.7
Arm fat mass (right) 0.3 1.1 4.4 -0.4 0.6 -2.1 -0.5 -1.1 -0.4
Trunk predicted mass 0.0 0.3 0.9 -0.3 0.0 0.1 0.6 1.0 0.2
Standing height 0.4 4.0 9.6 2.0 -2.7 0.1 3.1 1.0 -1.5
Length of working week for main job 0.2 0.3 0.6 0.8 0.0 -0.1 -0.3 -0.5 -0.7
Exposure to tobacco smoke at home 0.4 0.4 1.2 -0.2 -0.1 -0.8 -0.6 -0.7 -1.1
Breastfed as a baby 0.4 0.5 1.8 0.6 0.1 -1.3 -0.7 0.4 -0.5
Tense / ‘highly strung’ 0.4 0.6 2.2 0.9 -1.5 0.3 0.1 -0.0 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.9 0.0 -0.5 -0.9 -0.5 0.1 -0.4
Hair/balding pattern: Pattern 4 0.4 0.9 1.8 0.8 -1.0 0.9 -1.0 -0.2 -1.3
Birth weight of first child 0.5 0.9 4.3 -0.1 -0.1 0.9 2.1 -0.8 -0.1
Peak expiratory flow (PEF) 1.0 2.3 5.2 -1.6 2.3 -1.1 -1.5 0.2 1.7
Pulse wave reflection index 0.8 0.9 4.6 0.1 0.2 2.2 -0.4 0.7 -0.5
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 0.4 -0.3 -0.2 0.0 -0.9 -0.7
Loud music exposure frequency 1.4 1.6 2.6 1.1 -1.6 1.6 0.1 -1.2 -1.2
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 3.6 -1.3 0.7 1.0 1.8 1.9 1.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.9 1.4 -1.2 0.1 0.1 0.5 -0.6
Blood clot in the leg (DVT) 0.5 0.7 1.4 -1.0 1.2 0.1 -1.1 -0.1 0.5
Medication: Paracetamol 0.4 0.7 2.5 0.5 -0.7 0.9 1.6 -0.3 0.1
Headache pain in last month 1.8 3.1 9.2 0.8 -1.8 1.6 3.0 1.7 0.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.7 3.1 -0.1 -0.3 1.8 -1.0 0.5 -0.3
Glaucoma (self-reported) 0.2 0.2 0.4 0.5 -0.2 -0.6 0.4 0.6 -0.6
Gout (self-reported) 1.3 1.7 3.8 -1.5 1.7 -0.5 -0.0 -2.0 1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.0 0.1 -0.6 1.4 -0.2 -1.1 -0.9
Medication: Amlodipine 1.5 2.1 3.1 -1.6 1.3 -1.3 0.7 1.6 1.8
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.8 0.6 -0.9 0.1 0.5 0.3 -0.6
Birth weight 0.4 0.8 2.9 1.7 -0.6 0.4 -0.9 0.1 -0.7
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.4 -0.7 0.4 1.2 0.4 -0.8 0.2
High blood pressure (siblings) 1.2 1.8 4.2 -1.4 2.1 -1.5 -1.5 -0.3 0.4
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 -0.0 0.1 -0.2 0.5 0.2 -0.3
Body fat percentage 0.3 1.2 3.5 0.4 -0.2 -1.9 0.5 -1.6 -1.0
Leg fat percentage (right) 0.5 1.6 5.1 1.1 -0.8 -0.9 0.3 -2.2 -1.4
Arm fat-free mass (right) 0.1 0.7 1.4 -1.0 0.7 -0.0 1.2 0.8 1.0
Exposure to tobacco smoke outside home 0.2 0.3 0.6 0.3 -0.6 0.8 -0.2 -0.4 -0.6
Comparative body size at age 10 0.3 0.8 2.1 0.6 -1.1 1.1 0.1 0.1 -1.5
Number of full brothers 1.0 1.3 3.1 -0.7 1.8 -1.6 -0.7 0.2 1.1
Worry too long after embarrassment 0.7 1.2 2.2 0.8 -1.3 0.9 -0.2 -1.4 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 3.0 1.3 -1.5 0.3 -1.7 -0.6 -1.5
Wheeze or whistling in the chest in last year 0.3 0.5 1.6 -0.2 -0.1 -1.3 1.1 -0.2 0.4
Number of children fathered 1.0 1.1 3.8 0.1 0.7 -1.9 -1.5 -0.2 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.7 -1.1 1.2 -0.5 -0.1 -1.6 0.7
Age at first live birth 0.3 0.5 1.6 0.5 -0.3 0.6 1.3 -0.4 -0.6
Pulse wave peak to peak time 0.6 0.8 3.9 -0.1 0.2 -2.0 -0.6 -0.4 0.2
Health satisfaction 1.0 1.2 2.9 0.8 -0.8 1.7 -1.3 1.0 -0.9
Shortness of breath walking on level ground 1.2 1.4 3.2 1.8 -1.7 0.5 -0.5 0.4 -1.3
Qualifications: College or University degree 0.4 1.4 2.6 -1.3 1.5 1.6 0.0 -0.2 1.3
Eye problems/disorders: None of the above 0.4 0.5 1.8 0.7 -1.3 -0.1 0.4 -0.4 -0.6
Mouth/teeth dental problems: Loose teeth 1.6 1.9 6.8 0.5 -1.4 0.9 -2.6 -0.4 -1.2
Emphysema/chronic bronchitis 0.3 0.3 0.4 0.5 -0.6 0.6 0.6 0.1 -0.7
Medication for pain relief, constipation, heartburn 0.3 0.4 1.8 -0.6 0.5 -0.3 -1.4 0.0 -0.4
Neck or shoulder pain in last month 0.8 1.2 2.9 1.3 -1.5 -0.4 1.7 0.1 -0.4
Medication: Blood pressure 0.5 0.9 4.4 -0.5 0.5 -2.1 0.5 -0.2 0.7
Angina (self-reported) 0.9 1.2 3.8 -0.1 0.1 -1.2 -1.9 -1.3 -0.3
Migraine (self-reported) 0.3 0.4 0.9 -0.4 0.5 0.7 -0.1 0.9 0.8
Medication: Ibuprofen 0.6 0.7 1.8 0.8 -0.8 0.5 1.4 -0.9 0.0
Medication: Allopurinol 1.5 1.9 9.4 -0.4 0.9 -1.1 -0.1 -3.1 -0.3
Medication: Omeprazole 0.5 0.7 1.6 0.6 -0.4 -0.8 1.3 -0.6 -0.8
Medication: Seretide 50 evohaler 1.3 1.5 7.9 -0.7 -0.1 0.0 2.8 0.3 0.6
Mean time to correctly identify matches 0.5 0.9 5.2 -0.5 -0.3 -2.3 -0.1 -0.3 -0.1
Heart disease (mother) 0.5 0.6 1.1 -0.5 0.7 -1.0 1.1 0.5 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.1 2.9 -1.7 1.7 -1.5 -1.5 0.7 1.5
Whole body fat mass 0.2 0.9 3.3 -0.2 0.2 -1.8 0.6 -1.2 -0.5
Leg fat mass (right) 0.2 0.8 2.4 -0.1 0.2 -1.6 0.4 -1.4 -0.5
Arm predicted mass (right) 0.2 1.0 1.4 -1.1 0.8 -0.2 1.2 1.1 1.1
Pulse rate, automated reading 0.6 1.8 3.7 0.9 -1.5 1.9 1.3 -1.3 -0.9
Alcohol intake frequency. 0.2 0.6 1.0 0.8 -0.9 -0.7 -1.0 -0.4 -0.6
Comparative height size at age 10 0.1 0.5 1.0 -0.4 0.5 -0.9 1.0 0.6 0.5
Number of full sisters 0.5 0.6 1.2 -0.4 1.1 -1.1 -1.0 -0.6 -0.1
Suffer from ‘nerves’ 4.1 6.5 10.4 2.2 -2.8 0.5 -2.4 -3.1 -3.2
Overall health rating 0.4 0.8 2.6 -0.0 0.1 -1.1 -0.6 -1.6 -0.7
Chest pain or discomfort 0.6 0.9 2.5 -0.9 0.6 -1.6 -0.9 -1.0 0.1
Had major operations 0.2 0.2 0.9 0.3 -0.1 0.1 1.0 0.2 0.3
Age at last live birth 0.3 0.4 1.1 0.6 -0.6 0.8 1.1 0.4 -0.3
Family relationship satisfaction 0.6 0.7 2.2 -0.4 0.3 -0.5 -1.5 -1.2 -0.1
Leg pain on walking 0.9 1.1 2.7 1.6 -0.5 1.4 -0.2 -0.2 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 0.0 0.2 -1.0 0.1 -1.1 -0.7
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.1 -0.8 0.8 -1.4 0.8 -1.0 1.3
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.1 1.2 -1.1 1.8 1.0 0.1 -1.0
Medication: Aspirin 0.1 0.2 0.4 0.5 -0.2 0.3 -0.5 0.6 0.1
Supplements: Vitamin C 0.5 0.6 2.7 -0.3 -0.4 -0.3 1.6 -0.6 -0.5
Knee pain experienced in last month 2.6 4.1 14.2 -1.6 2.2 -3.8 -1.0 -0.8 1.0
Hypertension (Self-reported) 3.3 9.1 15.7 -4.0 3.6 -4.0 -0.0 0.8 3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.0 1.2 -0.7 -0.8 1.5 -1.7 -1.1
Illnesses of father: Heart disease 0.5 0.7 3.0 -0.6 0.7 -1.7 -0.2 0.2 0.7
Illnesses of siblings: Diabetes 0.4 0.5 1.3 -0.4 0.2 -0.6 1.0 -1.2 0.4
Smoking status: Previous 0.2 0.3 1.1 -0.7 0.3 -0.2 0.4 1.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.0 -0.9 1.0 -1.7 0.7 -1.0 0.2
Whole body fat-free mass 0.1 0.8 1.5 -1.2 0.9 -0.8 0.3 1.0 0.8
Leg fat-free mass (right) 0.4 2.1 4.1 -1.9 1.7 -2.0 -0.5 0.8 1.1
Arm fat percentage (left) 0.4 1.6 7.0 -0.3 0.5 -2.6 -0.6 -1.3 -0.5
Average weekly red wine intake 0.2 0.2 0.6 -0.6 0.6 0.7 -0.2 0.0 0.2
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.3 1.1 -1.5 1.3 0.1 -1.3 -1.3
Mood swings 1.1 2.0 4.9 0.5 -0.7 -1.0 -2.2 -1.8 -1.6
Loneliness, isolation 0.3 0.5 1.3 0.0 -0.5 -1.1 -0.8 -0.7 -0.3
Long-standing illness, disability or infirmity 0.5 0.8 2.1 -0.9 1.0 -0.7 -0.0 -1.4 0.6
Ever had bowel cancer screening 0.0 0.0 0.1 -0.1 -0.1 0.1 -0.2 0.1 -0.1
Diabetes diagnosed by doctor 0.1 0.2 0.7 -0.6 0.0 0.0 0.4 0.3 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.1 -1.1 0.9 0.3 0.5 1.8 1.3
Friendships satisfaction 0.3 0.4 0.6 0.7 -0.7 0.8 0.5 -0.5 -0.6
Qualifications: nursing, teaching 1.2 1.8 3.3 -1.7 1.8 0.5 1.1 0.7 1.6
Commuting to job workplace: Walk 0.4 0.4 1.1 -0.6 0.5 -0.3 -0.5 1.1 0.6
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.1 0.5 1.0 -0.6 0.6 0.3
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 -0.5 0.8 -0.8 -0.9 -0.6 0.3
Medication for cholesterol 2.0 3.1 7.3 2.7 -2.3 1.7 0.3 -0.5 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.4 0.9 -1.0 -0.2 -1.4 -1.0 -1.6
Back pain experienced in last month 0.4 0.6 1.8 0.7 -0.4 -1.3 0.8 -0.5 -0.5
Mineral and other dietary supplements 0.1 0.1 0.8 0.2 0.1 -0.0 0.1 -0.9 0.1
Breast cancer (self-reported) 0.7 0.8 1.8 1.2 -1.3 0.8 -0.6 -0.1 -0.8
Asthma (self-reported) 0.8 1.7 3.7 -1.9 1.4 -0.6 -0.3 0.9 1.7
Osteoporosis (self-reported) 1.1 1.4 3.4 1.8 -1.3 -1.2 -0.4 0.2 -1.3
Osteoarthritis (self-reported) 1.1 1.4 2.7 -1.3 1.7 0.5 0.4 1.2 1.5
Medication: Aspirin 0.1 0.1 0.7 -0.0 0.2 -0.0 -0.2 0.8 0.4
Medication: Gliclazide 0.3 0.3 0.6 -0.8 0.3 -0.7 0.4 -0.1 0.8
Illnesses of father: None of the above (group 1) 3.1 3.8 5.0 1.8 -1.5 2.2 -2.2 -1.8 -2.0
Smoking status: Current 0.9 1.4 3.4 1.6 -1.9 -0.8 0.9 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.1 -0.6 1.1 -1.5 -0.6 1.3 0.9
Whole body water mass 0.1 0.7 1.4 -1.2 0.9 -0.7 0.3 1.0 0.8
Leg predicted mass (right) 0.4 2.1 4.1 -1.9 1.7 -2.0 -0.5 0.8 1.1
Arm fat mass (left) 0.3 1.2 5.3 -0.4 0.6 -2.3 -0.5 -1.1 -0.3
Number of self-reported non-cancer illnesses 0.7 1.2 2.1 -1.4 1.4 -1.0 -0.6 1.0 0.9
Average weekly champagne plus white wine intake 0.7 1.0 4.5 0.1 -0.1 2.1 0.7 1.0 0.2
Miserableness 0.9 1.5 6.4 -0.9 0.5 -2.5 -0.4 -1.3 0.2
Guilty feelings 0.9 1.3 3.3 1.3 -1.2 -0.7 0.3 -1.8 -0.9
Wears glasses or contact lenses 1.4 1.6 4.1 -1.3 0.5 2.0 0.3 1.8 0.5
Ever taken oral contraceptive pill 2.1 2.3 5.2 2.1 -1.3 0.8 -1.0 -1.0 -2.3
Hearing aid user 1.6 1.8 6.6 -0.3 0.4 -2.0 -0.4 -2.6 -0.2
Mother’s age at death 1.6 2.0 3.4 1.6 -1.8 1.4 1.0 0.9 -1.5
Financial situation satisfaction 1.9 2.3 5.6 2.4 -2.2 0.8 0.4 -0.7 -1.5
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.5 -0.9 1.1 -2.1 -0.5 0.5 0.8
Commuting to job workplace: Public transport 3.7 4.4 8.3 2.6 -2.5 -0.3 -1.8 -1.6 -2.9
Eye problems/disorders: Glaucoma 0.3 0.4 1.1 0.7 -0.5 -0.3 1.1 0.1 -0.7
Medication: Blood pressure 2.6 4.9 8.8 -3.0 3.0 -2.8 -1.1 -0.5 1.7
Pain type(s) experienced in last month: Hip pain 1.3 1.7 4.4 -1.1 0.6 -1.2 2.1 1.2 1.2
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.9 0.9 -1.4 1.1 0.1 0.2 -1.2
High cholesterol (Self-reported) 0.2 0.4 0.8 -0.5 0.7 -0.1 -0.7 0.8 0.9
Medication: Bendroflumethiazide 3.0 4.5 11.9 -2.2 2.4 -3.5 -1.2 0.3 1.8
Medication: Paracetamol 0.6 0.9 4.1 0.4 -0.7 0.7 2.0 -0.1 0.2
Medication: Lisinopril 0.3 0.4 1.1 -0.5 0.6 -0.8 0.2 -0.3 1.0
Medication: Atorvastatin 0.2 0.2 0.7 0.2 -0.0 -0.8 -0.2 0.7 -0.1
Illnesses of father: High blood pressure 2.5 3.1 6.7 -2.5 2.6 -1.6 0.7 -0.8 1.3
Alcohol drinker status: Never 0.3 0.4 0.7 -0.9 0.8 0.2 -0.0 -0.8 0.5
Ever smoked 0.4 0.7 1.3 0.7 -1.1 0.3 1.1 1.1 -0.6
Basal metabolic rate 0.1 0.6 1.0 -1.0 0.8 -1.0 0.3 0.6 0.6
Leg fat percentage (left) 0.4 1.3 5.1 0.5 -0.1 -1.4 0.2 -2.2 -0.9
Arm fat-free mass (left) 0.1 0.5 0.8 -0.9 0.6 -0.2 0.9 0.7 0.8
Number of operations (self-reported) 0.3 0.5 1.4 -0.3 1.0 -0.2 -0.5 1.2 0.5
Average weekly beer plus cider intake 0.9 1.4 3.5 -0.6 1.9 -0.9 -1.5 -1.0 0.4
Irritability 0.4 0.6 2.4 0.5 -0.9 -0.2 -0.1 -1.5 -0.5
Risk taking 3.1 4.5 9.0 -2.1 3.0 -2.3 -2.4 0.7 1.4
Ever had prostate specific antigen (PSA) test 0.9 1.1 3.0 0.7 -0.5 -1.7 0.1 -1.3 -1.0
Fractured/broken bones in last 5 years 0.6 0.8 2.0 -1.4 1.3 -0.6 0.3 0.2 0.6
Age started oral contraceptive pill 2.4 3.0 6.9 2.6 -2.4 -0.4 1.0 -1.1 -1.7
Diastolic blood pressure, automated reading 2.8 8.5 19.6 -4.2 4.4 -2.2 0.3 0.5 3.0
Ever depressed for a whole week 6.4 7.8 14.0 3.7 -3.4 0.2 -1.5 -2.6 -3.5
Unable to work because of sickness or disability 0.3 0.3 1.4 -0.2 0.6 -0.4 -0.3 -1.2 -0.2
Commuting to job workplace: Cycle 0.4 0.5 1.1 0.9 0.3 -0.3 -1.1 -0.8 -0.6
Myopia 0.8 1.2 4.6 -0.8 -0.2 1.1 0.4 2.2 0.6
Vascular/heart problems diagnosed by doctor 2.7 7.5 16.3 3.4 -3.4 4.0 0.6 -0.3 -2.1
Cholesterol lowering medication 1.6 2.3 4.1 -1.7 1.8 -1.8 -0.2 0.6 2.0
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.6 1.1 -0.9 -0.4 1.3 -0.9 -1.2
Pain experienced in last month 0.6 1.0 3.7 -0.6 0.7 1.9 -1.1 -0.3 -0.2
Supplements: Calcium 1.0 1.1 3.2 1.4 -1.8 0.4 -0.2 -0.4 -1.2
Basal cell carcinoma (self-reported) 0.3 0.3 1.3 -0.6 -0.0 0.2 0.4 1.1 0.0
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 0.3 -0.7 0.2 1.4 0.3 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.2 -0.9 1.4 0.1 -1.5 -0.0 0.4
Heart disease (siblings) 1.2 1.5 3.9 -0.8 1.4 -0.0 2.0 0.8 1.5
Alcohol drinker status: Previous 0.3 0.3 1.0 0.4 -0.5 -1.0 -0.2 -0.4 -0.5
Pack years of smoking 1.9 2.7 5.0 2.0 -1.7 0.0 -0.6 -2.0 -2.2
Impedance of whole body 1.1 5.5 9.1 3.0 -3.0 0.1 2.5 -1.9 -2.3
Leg fat mass (left) 0.3 1.1 3.9 -0.5 0.7 -2.0 0.3 -1.4 -0.1
Arm predicted mass (left) 0.1 0.3 0.6 -0.8 0.6 -0.1 0.7 0.3 0.6