Hub : Genes

LY6E

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.4680	0.1160	3.8e-03	0.147	NA	0.032	NA	0.110	5.3e-05	NA	4.3e-02	NA	4.6e-04
2	GTEx	Cells Transformed fibroblasts	0.2120	0.0590	4.2e-06	0.090	NA	0.103	NA	0.100	3.0e-07	NA	3.8e-08	NA	6.0e-08
3	ROSMAP	Brain Pre-frontal Cortex	0.0809	0.0320	8.7e-04	0.002	0.019	0.005	0.024	0.004	1.7e-01	1.5e-03	7.6e-02	3.5e-04	1.0e-01
4	YFS	Blood	0.1390	0.0296	2.3e-13	0.070	0.065	0.075	0.079	0.071	5.8e-22	1.5e-20	1.6e-23	1.6e-24	2.5e-22
5	TCGA	Colon Adenocarcinoma	0.1040	0.0530	7.1e-04	0.059	0.056	0.034	NA	0.041	2.7e-04	3.4e-04	4.4e-03	NA	2.1e-03
6	TCGA	Thyroid Carcinoma	0.1510	0.0520	2.2e-12	0.144	0.152	0.137	NA	0.142	6.3e-14	1.2e-14	2.9e-13	NA	1.0e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.0	3.1	6.7	-1.1	1.2	0.2	2.0	2.3	2.6
Bipolar Disorder or Schizophrenia	1.3	3.1	6.9	-1.5	1.2	-1.3	1.0	2.6	2.3
Depressed Affect (Nagel 2018)	1.3	2.8	4.5	1.6	-1.9	-1.3	-1.1	-2.1	-1.9
Depression (Nagel 2018)	0.6	0.9	2.3	0.8	-1.3	0.0	-0.6	-1.5	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.8	-0.8	0.6	1.0	1.3	0.2	1.4
Neuroticism (Nagel 2018)	1.8	4.3	8.1	1.9	-2.8	0.0	-0.6	-2.8	-2.5
Schizophrenia (2018)	0.6	1.2	3.4	-1.0	0.5	-1.9	-0.5	1.4	0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	-0.4	-0.3	-0.6	-1.4	1.4	0.1
Worry (Nagel 2018)	2.8	5.9	10.5	2.0	-3.2	1.0	-1.1	-3.1	-2.9
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	-1.5	0.4	0.0	0.1	1.2	0.6
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.0	0.6	-0.9	0.7	0.2	0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.7	-0.1	-0.2	0.6	0.5	0.2
Crohns Disease (2017)	0.3	0.6	3.0	0.3	-0.4	-0.3	0.1	1.7	0.5
Irritable Bowel Disease (IBD)	0.3	0.6	1.7	-0.3	-0.1	-1.2	0.4	1.3	0.7
Ulcerative Colitis (UC)	0.7	1.3	2.8	-1.4	0.9	-1.7	0.5	0.5	1.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.5	6.3	-1.3	0.7	-2.5	0.1	-0.3	0.6
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.0	-1.5	0.3	2.2	0.8	1.6	1.7
Breast Cancer	0.4	1.0	2.2	-0.8	1.5	0.5	0.4	1.1	1.3
Ovarian Cancer	0.6	0.8	1.5	1.0	-1.0	1.2	0.3	-0.2	-1.1
Prostate Cancer	0.4	0.5	2.7	0.1	0.0	-0.2	0.2	1.7	0.4
Age at First Birth	1.2	1.7	3.5	1.0	-1.6	1.9	-0.4	1.4	-1.1
Bipolar Disorder (2011)	1.0	1.0	3.3	-1.8	0.0	0.0	-0.2	1.7	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.0	-0.4	-0.3	-0.5	0.1	-0.5
Coronary Artery Disease (CAD)	2.1	2.6	7.4	-1.6	1.5	0.1	0.8	1.6	2.7
Crohns Disease (2012)	0.2	0.4	1.3	-0.4	0.6	-0.3	-0.2	0.5	1.1
Mean Putamen Volume	0.1	0.1	0.3	-0.6	-0.1	-0.4	-0.2	0.2	0.1
Fasting Glucose	1.1	1.3	3.6	1.9	-1.0	1.6	0.7	0.7	-0.2
HbA1C	0.4	0.4	0.9	0.9	-0.9	-0.6	0.8	0.1	-0.2
HDL Cholesterol	1.1	1.8	3.8	1.4	-2.0	1.9	-0.0	1.1	-0.8
LDL Cholesterol	0.1	0.1	0.3	0.4	0.2	-0.3	-0.2	-0.5	-0.1
Lupus	1.7	2.5	4.8	-1.6	1.4	-2.2	-1.1	1.7	1.2
Neuroticism (2016)	2.0	2.9	8.0	0.7	-1.4	0.3	-1.9	-2.8	-1.8
Primary Biliary Cirrhosis	0.8	1.1	4.6	-0.2	0.2	-2.1	-1.4	-0.3	0.0
Rheumatoid Arthritis	1.8	2.4	6.4	1.8	-1.1	-0.3	-0.9	-1.7	-2.5
Schizophrenia (2014)	1.8	4.1	7.3	-2.1	1.7	-2.1	-0.7	2.7	2.2
Triglycerides	0.8	1.4	3.9	0.3	-0.2	-2.0	0.7	-1.9	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.1	-0.1	-0.5	0.4	0.2	1.1	0.2
Ulcerative Colitis	0.8	1.1	2.9	-0.9	1.3	-1.7	-0.3	0.2	1.1
Blood Eosinophil Count	0.4	3.0	13.7	-1.1	1.0	-3.7	0.4	0.5	1.2
Blood Platelet Count	0.2	2.9	4.2	1.7	-2.0	2.0	1.1	-0.9	-2.0
Blood Red Count	0.1	1.1	4.4	0.6	-0.7	2.1	-0.3	-1.1	-0.5
Blood White Count	0.0	0.3	0.6	-0.7	0.3	-0.4	0.5	-0.7	-0.3
Heel T-Score	2.1	16.5	27.9	-5.3	5.0	-2.0	1.5	3.8	5.1
BMI	0.4	2.3	7.3	-1.3	1.8	-2.7	-0.7	-1.1	0.4
Height	0.5	10.4	26.5	3.1	-4.6	0.4	5.2	0.8	-2.2
Waist Hip Ratio (WHR)	0.7	2.9	6.0	2.5	-2.3	-0.2	-0.7	-1.2	-2.0
Systolic Blood Pressure	1.9	9.3	21.1	-3.9	4.6	-2.1	-3.0	-0.3	2.5
Smoking Status	0.5	1.1	3.0	1.2	-1.7	0.5	0.9	0.6	-1.1
Allergy or Eczema	0.1	0.2	0.7	-0.3	0.2	-0.2	0.2	0.7	0.8
Cardiovascular Disease	1.9	6.4	11.7	-3.3	3.4	-3.2	-0.5	0.3	2.3
Hypothyroidism (self reported)	0.3	0.7	2.4	0.2	-0.7	1.6	0.1	-0.6	-1.1
Respiratory disease	0.6	1.4	2.6	-1.3	1.1	-1.6	-1.5	-0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-1.0	0.3	0.8	0.2	0.5	0.7
Lung FEV1/FVC ratio	0.4	2.2	5.8	-0.2	1.0	-2.4	1.9	0.5	1.5
Lung FVC	0.2	1.0	3.7	-0.9	1.9	-0.8	-0.4	0.4	0.6
Neuroticism	2.1	5.1	8.9	2.1	-2.3	-0.7	-2.3	-3.0	-2.5
Chronotype (morning person)	0.1	0.1	0.5	-0.2	-0.0	-0.5	-0.0	-0.7	-0.3
Hair Pigment	0.0	1.1	2.0	-0.9	1.1	-1.4	-1.4	0.0	0.9
Tanning	0.1	1.4	3.7	0.9	-1.3	1.9	-0.4	-0.0	-1.4
Hand grip strength (left)	0.5	1.2	4.8	0.6	-0.3	0.9	-2.2	-0.6	-0.9
Number of treatments/medications taken	0.4	0.7	1.9	0.4	-0.6	-1.4	0.9	-0.9	-0.5
Average weekly spirits intake	0.4	0.5	1.7	-0.3	-0.4	-0.8	1.3	0.1	0.8
Sensitivity / hurt feelings	0.6	1.0	2.0	0.7	-1.4	-0.4	-0.4	-1.2	-1.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.0	-0.1	-0.3	-2.0	-1.4	-1.7	-0.5
Hearing difficulty/problems: Yes	1.4	2.1	3.6	-1.7	1.7	-1.9	-0.4	-1.6	0.8
Relative age of first facial hair	0.2	0.4	1.3	-0.4	0.7	0.7	-1.2	0.1	0.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.9	-2.2	2.1	0.1	0.1	0.5	1.7
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.0	1.0	-1.7	2.0	-2.0	1.2	-1.3
Ever had hysterectomy (womb removed)	0.8	0.9	3.5	-0.6	0.6	0.6	-1.9	0.7	-0.1
Systolic blood pressure, automated reading	2.5	7.3	17.6	-3.8	4.2	-1.1	-0.7	0.6	3.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.5	-1.6	0.9	-0.2	0.5	1.6	2.1
Angina	1.0	1.3	4.5	-0.2	0.3	-1.3	-2.1	-1.3	-0.2
Medication for hormone replacement therapy	0.4	0.5	1.2	0.4	-0.5	1.1	-0.7	0.1	-0.9
Vitamin and mineral supplements	0.1	0.1	0.3	0.0	0.4	0.4	0.3	0.5	0.3
Supplements: Zinc	0.3	0.3	0.5	0.4	-0.6	-0.6	0.5	0.5	-0.7
Medication: Co-codamol	0.2	0.2	1.0	0.2	1.0	-0.3	0.3	-0.4	0.3
Medication: Metformin	0.2	0.3	1.0	0.1	-0.7	0.3	-1.0	-0.2	0.0
Diabetes (father)	1.3	1.6	5.4	-0.6	0.1	2.3	1.6	1.1	0.5
Diabetes (mother)	0.8	1.0	3.5	-0.6	0.4	-1.9	0.3	-1.2	0.7
Severe depression (siblings)	0.5	0.5	1.4	1.2	-0.7	-0.6	0.3	-0.6	-0.7
Pack years adult smoking proportion	2.0	3.0	5.5	2.1	-1.6	0.0	-0.5	-2.3	-2.4
Impedance of leg (right)	1.7	8.1	12.8	3.5	-3.6	1.9	3.1	-2.0	-2.5
Leg fat-free mass (left)	0.3	1.5	3.3	-1.5	1.3	-1.8	-0.4	0.7	0.8
Trunk fat percentage	0.4	1.5	4.5	0.5	-0.4	-2.1	0.9	-1.7	-0.9
Hand grip strength (right)	0.4	1.1	1.8	1.1	-0.7	1.3	-1.1	-0.6	-1.1
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.3	0.2	0.0	-0.2	0.3	-0.0
Current tobacco smoking	0.6	1.0	2.6	1.4	-1.6	-0.5	1.0	-0.1	-0.7
Average weekly fortified wine intake	1.8	2.1	6.6	0.7	-1.2	1.8	2.6	-0.5	-0.4
Maternal smoking around birth	0.4	0.6	1.2	-1.0	0.1	1.1	0.6	-0.8	0.5
Fed-up feelings	1.4	2.6	3.4	1.8	-1.7	-1.4	-1.4	-1.5	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.7	-0.2	-0.2	-0.8	-1.2	-1.9	-0.2
Relative age voice broke	1.6	2.4	5.5	1.8	-1.2	2.4	-0.3	-1.0	-1.7
Taking other prescription medications	0.7	1.1	2.4	1.2	-1.5	1.1	0.3	-0.4	-1.1
Age when periods started (menarche)	0.5	1.1	2.2	1.2	-1.5	0.7	1.3	0.9	-0.4
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.8	-1.4	2.0	-0.4	-2.2	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	6.4	-2.5	2.5	-1.6	0.7	0.3	2.0
Tinnitus: Yes, but not now, but have in the past	5.9	6.3	11.0	3.1	-2.4	1.8	-2.9	-0.1	-3.3
Qualifications: CSEs or equivalent	0.6	0.8	2.1	-0.9	1.4	-0.8	-0.4	0.1	1.1
Serious illness, injury or assault to yourself	0.5	0.5	0.9	-0.9	0.6	-1.0	-0.3	-0.9	0.5
High blood pressure	3.4	9.5	17.2	-4.0	3.9	-4.1	-0.4	0.4	2.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.5	0.0	-0.2	0.2	-0.3	1.2	0.4
Multivitamins +/- minerals	0.3	0.3	0.6	-0.6	0.1	-0.8	-0.5	0.4	0.8
Stomach or abdominal pain in last month	1.3	1.6	3.4	1.8	-1.3	0.2	-0.6	-1.1	-1.7
Supplements: Glucosamine	1.2	1.5	2.7	-1.6	1.5	-0.7	-0.8	0.9	1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.1	0.7	-0.6	-0.7	1.5	-0.6	-0.2
Medication: Atenolol	0.5	0.6	1.5	-1.0	1.0	-1.2	0.2	0.0	0.4
Medication: Levothyroxine sodium	0.3	0.4	1.5	0.1	-0.1	0.8	0.0	-1.2	-0.7
Sitting height	0.3	1.9	7.5	0.6	-1.5	-1.0	2.7	0.2	-0.4
Chronic bronchitis/emphysema (father)	1.8	2.1	3.7	-1.6	1.5	0.6	1.4	1.9	1.5
High blood pressure (mother)	2.1	2.9	7.1	-1.9	2.7	-1.5	0.3	1.0	1.8
Body mass index (BMI)	0.4	1.8	4.1	-1.1	1.5	-2.0	-1.2	-1.1	0.5
Impedance of leg (left)	1.4	6.6	9.5	3.1	-3.0	1.4	3.0	-2.4	-2.1
Leg predicted mass (left)	0.3	1.4	3.0	-1.5	1.3	-1.7	-0.5	0.7	0.8
Trunk fat mass	0.3	1.1	4.4	0.1	-0.1	-2.1	0.9	-1.1	-0.7
Waist circumference	0.2	0.6	2.7	0.1	-0.1	-1.6	-0.3	-0.6	-0.4
Number of incorrect matches in round	1.1	1.8	2.5	1.5	-1.6	0.9	-0.9	-1.5	-1.6
Past tobacco smoking	0.3	0.5	1.8	0.6	-0.1	0.6	-0.6	-1.3	-0.4
Alcohol usually taken with meals	0.5	0.9	2.4	-1.3	0.1	0.4	0.1	1.5	1.0
Nervous feelings	1.4	2.6	4.2	1.0	-1.6	0.1	-2.0	-2.0	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	1.1	-1.1	-0.6	0.7	-0.3	-0.7
Hearing difficulty/problems with background noise	0.7	1.1	3.3	-0.1	0.6	-1.6	-0.0	-1.8	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.4	-1.1	1.4	-0.6	-0.0	0.4	1.6
Had menopause	0.6	0.8	2.9	-0.6	0.1	-0.1	-0.9	1.7	0.8
Had other major operations	0.3	0.4	2.0	0.4	0.4	-1.4	-0.2	0.1	-0.2
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.3	0.7	-0.5	0.3	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	8.9	-3.0	2.8	-0.8	0.2	1.1	2.4
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	5.7	2.4	-2.3	-0.5	-1.1	-0.7	-2.3
Qualifications: None of the above	2.0	4.3	9.5	3.1	-2.3	-0.6	-0.9	-1.6	-2.8
Financial difficulties in last 2 years	0.4	0.6	1.5	-1.2	0.9	-0.0	0.0	0.5	0.9
Mouth/teeth dental problems	0.3	0.4	2.1	-0.1	0.2	0.4	1.4	0.1	0.5
Heart attack	0.3	0.3	1.5	0.2	-0.6	-0.1	1.2	0.2	-0.2
Allergy	0.5	1.2	2.1	1.4	-1.1	0.3	1.1	-0.9	-1.4
Pain all over the body in last month	2.5	2.7	4.2	2.0	-1.7	2.0	0.1	-1.4	-1.7
Diabetes (self-reported)	0.1	0.1	0.3	-0.5	-0.1	-0.3	0.3	-0.1	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.9	-1.1	1.1	-0.5	-0.9	1.4	1.1
Medication: Ramipril	1.2	1.6	4.1	-0.4	1.1	-2.0	-1.3	-1.5	-0.3
Medication: Simvastatin	0.9	1.4	2.7	-1.0	1.4	-1.6	0.2	-0.2	1.6
Fluid intelligence score	0.7	1.5	3.0	-1.5	0.1	0.6	0.7	1.6	1.7
Illnesses of siblings	0.7	0.9	2.5	0.9	-1.6	0.3	-0.4	-1.0	-0.9
Neuroticism score	2.1	4.4	9.6	1.7	-2.2	-0.5	-1.8	-3.1	-2.3
Weight	0.1	0.7	3.4	-0.2	0.2	-1.8	0.2	-0.7	-0.3
Impedance of arm (right)	0.9	4.3	7.4	2.7	-2.5	-0.5	1.1	-1.8	-2.7
Arm fat percentage (right)	0.4	1.5	5.6	-0.2	0.6	-2.4	-0.8	-1.4	-0.7
Trunk fat-free mass	0.0	0.2	0.8	-0.4	0.1	-0.0	0.6	0.9	0.3
Hip circumference	0.4	1.6	5.2	-1.4	1.3	-2.3	0.4	-0.3	0.7
Time employed in main current job	0.7	0.8	1.7	0.8	-1.0	0.5	-0.4	-0.8	-1.3
Alcohol intake versus 10 years previously	1.4	2.1	6.6	2.6	-1.4	-0.2	-0.9	0.6	-1.6
Father’s age at death	1.1	1.5	4.1	1.1	-0.5	2.0	-1.5	0.2	-1.2
Worrier / anxious feelings	0.9	1.8	6.2	0.9	-2.5	0.1	1.3	-0.8	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.8	-0.9	1.1	-2.0	0.0	-0.3	1.2
Falls in the last year	0.7	0.9	2.2	-0.8	0.9	-1.5	-1.2	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	-0.0	-0.2	-1.0	-0.1	-0.9	-0.5
Number of live births	0.8	1.1	3.5	-1.1	0.7	-1.9	0.2	0.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.1	-0.7	1.5	-1.3	-0.8	0.7	0.9
Pulse rate	0.4	0.7	1.9	1.1	-0.6	-0.4	0.6	-1.4	-0.6
Happiness	1.1	1.3	2.8	1.7	-1.5	-0.0	-0.3	-1.0	-1.3
Noisy workplace	1.3	1.6	5.3	0.2	0.6	-0.4	-2.3	-1.7	-0.8
Qualifications: A levels/AS levels or equivalent	1.8	3.9	7.1	-1.8	1.9	1.2	2.1	2.0	2.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.5	-1.3	1.2	-0.9	-0.5	0.8	1.6
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	-1.0	0.5	0.4	-0.5	0.4	0.2
Asthma	1.0	1.9	4.5	-2.1	1.7	-0.6	-0.5	0.8	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	3.0	0.5	-0.3	0.6	1.7	-0.2	0.6
Medication: Cholesterol lowering	0.8	1.2	3.3	1.0	-0.7	-1.4	-0.1	-1.8	-0.7
Depression (self-reported)	0.3	0.4	1.1	-0.5	0.1	0.9	-1.1	0.4	-0.0
Medication: Lansoprazole	0.3	0.4	1.4	0.4	-0.4	-0.7	0.3	-1.2	-0.4
Prospective memory result	1.3	1.6	3.1	1.2	-0.7	0.8	-1.2	-1.8	-1.4
Lung cancer (father)	0.3	0.4	0.8	0.9	-0.6	0.3	0.9	0.5	-0.4
Illnesses of mother	2.8	3.5	5.2	2.1	-2.3	1.6	-1.4	-1.5	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.4	-0.8	1.1	-1.2	-0.2	0.7	0.8
Pulse wave Arterial Stiffness index	0.7	0.9	3.4	0.0	-0.2	1.9	1.0	0.8	0.1
Impedance of arm (left)	1.1	4.9	8.9	3.0	-3.0	-0.7	1.2	-1.5	-2.7
Arm fat mass (right)	0.3	1.1	4.4	-0.4	0.6	-2.1	-0.5	-1.1	-0.4
Trunk predicted mass	0.0	0.3	0.9	-0.3	0.0	0.1	0.6	1.0	0.2
Standing height	0.4	4.0	9.6	2.0	-2.7	0.1	3.1	1.0	-1.5
Length of working week for main job	0.2	0.3	0.6	0.8	0.0	-0.1	-0.3	-0.5	-0.7
Exposure to tobacco smoke at home	0.4	0.4	1.2	-0.2	-0.1	-0.8	-0.6	-0.7	-1.1
Breastfed as a baby	0.4	0.5	1.8	0.6	0.1	-1.3	-0.7	0.4	-0.5
Tense / ‘highly strung’	0.4	0.6	2.2	0.9	-1.5	0.3	0.1	-0.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.0	-0.5	-0.9	-0.5	0.1	-0.4
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	0.8	-1.0	0.9	-1.0	-0.2	-1.3
Birth weight of first child	0.5	0.9	4.3	-0.1	-0.1	0.9	2.1	-0.8	-0.1
Peak expiratory flow (PEF)	1.0	2.3	5.2	-1.6	2.3	-1.1	-1.5	0.2	1.7
Pulse wave reflection index	0.8	0.9	4.6	0.1	0.2	2.2	-0.4	0.7	-0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.4	-0.3	-0.2	0.0	-0.9	-0.7
Loud music exposure frequency	1.4	1.6	2.6	1.1	-1.6	1.6	0.1	-1.2	-1.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.6	-1.3	0.7	1.0	1.8	1.9	1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	1.4	-1.2	0.1	0.1	0.5	-0.6
Blood clot in the leg (DVT)	0.5	0.7	1.4	-1.0	1.2	0.1	-1.1	-0.1	0.5
Medication: Paracetamol	0.4	0.7	2.5	0.5	-0.7	0.9	1.6	-0.3	0.1
Headache pain in last month	1.8	3.1	9.2	0.8	-1.8	1.6	3.0	1.7	0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.7	3.1	-0.1	-0.3	1.8	-1.0	0.5	-0.3
Glaucoma (self-reported)	0.2	0.2	0.4	0.5	-0.2	-0.6	0.4	0.6	-0.6
Gout (self-reported)	1.3	1.7	3.8	-1.5	1.7	-0.5	-0.0	-2.0	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.0	0.1	-0.6	1.4	-0.2	-1.1	-0.9
Medication: Amlodipine	1.5	2.1	3.1	-1.6	1.3	-1.3	0.7	1.6	1.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.6	-0.9	0.1	0.5	0.3	-0.6
Birth weight	0.4	0.8	2.9	1.7	-0.6	0.4	-0.9	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	-0.7	0.4	1.2	0.4	-0.8	0.2
High blood pressure (siblings)	1.2	1.8	4.2	-1.4	2.1	-1.5	-1.5	-0.3	0.4
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.0	0.1	-0.2	0.5	0.2	-0.3
Body fat percentage	0.3	1.2	3.5	0.4	-0.2	-1.9	0.5	-1.6	-1.0
Leg fat percentage (right)	0.5	1.6	5.1	1.1	-0.8	-0.9	0.3	-2.2	-1.4
Arm fat-free mass (right)	0.1	0.7	1.4	-1.0	0.7	-0.0	1.2	0.8	1.0
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.3	-0.6	0.8	-0.2	-0.4	-0.6
Comparative body size at age 10	0.3	0.8	2.1	0.6	-1.1	1.1	0.1	0.1	-1.5
Number of full brothers	1.0	1.3	3.1	-0.7	1.8	-1.6	-0.7	0.2	1.1
Worry too long after embarrassment	0.7	1.2	2.2	0.8	-1.3	0.9	-0.2	-1.4	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.0	1.3	-1.5	0.3	-1.7	-0.6	-1.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-0.2	-0.1	-1.3	1.1	-0.2	0.4
Number of children fathered	1.0	1.1	3.8	0.1	0.7	-1.9	-1.5	-0.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.7	-1.1	1.2	-0.5	-0.1	-1.6	0.7
Age at first live birth	0.3	0.5	1.6	0.5	-0.3	0.6	1.3	-0.4	-0.6
Pulse wave peak to peak time	0.6	0.8	3.9	-0.1	0.2	-2.0	-0.6	-0.4	0.2
Health satisfaction	1.0	1.2	2.9	0.8	-0.8	1.7	-1.3	1.0	-0.9
Shortness of breath walking on level ground	1.2	1.4	3.2	1.8	-1.7	0.5	-0.5	0.4	-1.3
Qualifications: College or University degree	0.4	1.4	2.6	-1.3	1.5	1.6	0.0	-0.2	1.3
Eye problems/disorders: None of the above	0.4	0.5	1.8	0.7	-1.3	-0.1	0.4	-0.4	-0.6
Mouth/teeth dental problems: Loose teeth	1.6	1.9	6.8	0.5	-1.4	0.9	-2.6	-0.4	-1.2
Emphysema/chronic bronchitis	0.3	0.3	0.4	0.5	-0.6	0.6	0.6	0.1	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.4	1.8	-0.6	0.5	-0.3	-1.4	0.0	-0.4
Neck or shoulder pain in last month	0.8	1.2	2.9	1.3	-1.5	-0.4	1.7	0.1	-0.4
Medication: Blood pressure	0.5	0.9	4.4	-0.5	0.5	-2.1	0.5	-0.2	0.7
Angina (self-reported)	0.9	1.2	3.8	-0.1	0.1	-1.2	-1.9	-1.3	-0.3
Migraine (self-reported)	0.3	0.4	0.9	-0.4	0.5	0.7	-0.1	0.9	0.8
Medication: Ibuprofen	0.6	0.7	1.8	0.8	-0.8	0.5	1.4	-0.9	0.0
Medication: Allopurinol	1.5	1.9	9.4	-0.4	0.9	-1.1	-0.1	-3.1	-0.3
Medication: Omeprazole	0.5	0.7	1.6	0.6	-0.4	-0.8	1.3	-0.6	-0.8
Medication: Seretide 50 evohaler	1.3	1.5	7.9	-0.7	-0.1	0.0	2.8	0.3	0.6
Mean time to correctly identify matches	0.5	0.9	5.2	-0.5	-0.3	-2.3	-0.1	-0.3	-0.1
Heart disease (mother)	0.5	0.6	1.1	-0.5	0.7	-1.0	1.1	0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	2.9	-1.7	1.7	-1.5	-1.5	0.7	1.5
Whole body fat mass	0.2	0.9	3.3	-0.2	0.2	-1.8	0.6	-1.2	-0.5
Leg fat mass (right)	0.2	0.8	2.4	-0.1	0.2	-1.6	0.4	-1.4	-0.5
Arm predicted mass (right)	0.2	1.0	1.4	-1.1	0.8	-0.2	1.2	1.1	1.1
Pulse rate, automated reading	0.6	1.8	3.7	0.9	-1.5	1.9	1.3	-1.3	-0.9
Alcohol intake frequency.	0.2	0.6	1.0	0.8	-0.9	-0.7	-1.0	-0.4	-0.6
Comparative height size at age 10	0.1	0.5	1.0	-0.4	0.5	-0.9	1.0	0.6	0.5
Number of full sisters	0.5	0.6	1.2	-0.4	1.1	-1.1	-1.0	-0.6	-0.1
Suffer from ‘nerves’	4.1	6.5	10.4	2.2	-2.8	0.5	-2.4	-3.1	-3.2
Overall health rating	0.4	0.8	2.6	-0.0	0.1	-1.1	-0.6	-1.6	-0.7
Chest pain or discomfort	0.6	0.9	2.5	-0.9	0.6	-1.6	-0.9	-1.0	0.1
Had major operations	0.2	0.2	0.9	0.3	-0.1	0.1	1.0	0.2	0.3
Age at last live birth	0.3	0.4	1.1	0.6	-0.6	0.8	1.1	0.4	-0.3
Family relationship satisfaction	0.6	0.7	2.2	-0.4	0.3	-0.5	-1.5	-1.2	-0.1
Leg pain on walking	0.9	1.1	2.7	1.6	-0.5	1.4	-0.2	-0.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	0.0	0.2	-1.0	0.1	-1.1	-0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.1	-0.8	0.8	-1.4	0.8	-1.0	1.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.1	1.2	-1.1	1.8	1.0	0.1	-1.0
Medication: Aspirin	0.1	0.2	0.4	0.5	-0.2	0.3	-0.5	0.6	0.1
Supplements: Vitamin C	0.5	0.6	2.7	-0.3	-0.4	-0.3	1.6	-0.6	-0.5
Knee pain experienced in last month	2.6	4.1	14.2	-1.6	2.2	-3.8	-1.0	-0.8	1.0
Hypertension (Self-reported)	3.3	9.1	15.7	-4.0	3.6	-4.0	-0.0	0.8	3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.0	1.2	-0.7	-0.8	1.5	-1.7	-1.1
Illnesses of father: Heart disease	0.5	0.7	3.0	-0.6	0.7	-1.7	-0.2	0.2	0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.4	0.2	-0.6	1.0	-1.2	0.4
Smoking status: Previous	0.2	0.3	1.1	-0.7	0.3	-0.2	0.4	1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.0	-0.9	1.0	-1.7	0.7	-1.0	0.2
Whole body fat-free mass	0.1	0.8	1.5	-1.2	0.9	-0.8	0.3	1.0	0.8
Leg fat-free mass (right)	0.4	2.1	4.1	-1.9	1.7	-2.0	-0.5	0.8	1.1
Arm fat percentage (left)	0.4	1.6	7.0	-0.3	0.5	-2.6	-0.6	-1.3	-0.5
Average weekly red wine intake	0.2	0.2	0.6	-0.6	0.6	0.7	-0.2	0.0	0.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.3	1.1	-1.5	1.3	0.1	-1.3	-1.3
Mood swings	1.1	2.0	4.9	0.5	-0.7	-1.0	-2.2	-1.8	-1.6
Loneliness, isolation	0.3	0.5	1.3	0.0	-0.5	-1.1	-0.8	-0.7	-0.3
Long-standing illness, disability or infirmity	0.5	0.8	2.1	-0.9	1.0	-0.7	-0.0	-1.4	0.6
Ever had bowel cancer screening	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	0.1	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.7	-0.6	0.0	0.0	0.4	0.3	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.1	-1.1	0.9	0.3	0.5	1.8	1.3
Friendships satisfaction	0.3	0.4	0.6	0.7	-0.7	0.8	0.5	-0.5	-0.6
Qualifications: nursing, teaching	1.2	1.8	3.3	-1.7	1.8	0.5	1.1	0.7	1.6
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.6	0.5	-0.3	-0.5	1.1	0.6
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.1	0.5	1.0	-0.6	0.6	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.5	0.8	-0.8	-0.9	-0.6	0.3
Medication for cholesterol	2.0	3.1	7.3	2.7	-2.3	1.7	0.3	-0.5	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	0.9	-1.0	-0.2	-1.4	-1.0	-1.6
Back pain experienced in last month	0.4	0.6	1.8	0.7	-0.4	-1.3	0.8	-0.5	-0.5
Mineral and other dietary supplements	0.1	0.1	0.8	0.2	0.1	-0.0	0.1	-0.9	0.1
Breast cancer (self-reported)	0.7	0.8	1.8	1.2	-1.3	0.8	-0.6	-0.1	-0.8
Asthma (self-reported)	0.8	1.7	3.7	-1.9	1.4	-0.6	-0.3	0.9	1.7
Osteoporosis (self-reported)	1.1	1.4	3.4	1.8	-1.3	-1.2	-0.4	0.2	-1.3
Osteoarthritis (self-reported)	1.1	1.4	2.7	-1.3	1.7	0.5	0.4	1.2	1.5
Medication: Aspirin	0.1	0.1	0.7	-0.0	0.2	-0.0	-0.2	0.8	0.4
Medication: Gliclazide	0.3	0.3	0.6	-0.8	0.3	-0.7	0.4	-0.1	0.8
Illnesses of father: None of the above (group 1)	3.1	3.8	5.0	1.8	-1.5	2.2	-2.2	-1.8	-2.0
Smoking status: Current	0.9	1.4	3.4	1.6	-1.9	-0.8	0.9	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.1	-0.6	1.1	-1.5	-0.6	1.3	0.9
Whole body water mass	0.1	0.7	1.4	-1.2	0.9	-0.7	0.3	1.0	0.8
Leg predicted mass (right)	0.4	2.1	4.1	-1.9	1.7	-2.0	-0.5	0.8	1.1
Arm fat mass (left)	0.3	1.2	5.3	-0.4	0.6	-2.3	-0.5	-1.1	-0.3
Number of self-reported non-cancer illnesses	0.7	1.2	2.1	-1.4	1.4	-1.0	-0.6	1.0	0.9
Average weekly champagne plus white wine intake	0.7	1.0	4.5	0.1	-0.1	2.1	0.7	1.0	0.2
Miserableness	0.9	1.5	6.4	-0.9	0.5	-2.5	-0.4	-1.3	0.2
Guilty feelings	0.9	1.3	3.3	1.3	-1.2	-0.7	0.3	-1.8	-0.9
Wears glasses or contact lenses	1.4	1.6	4.1	-1.3	0.5	2.0	0.3	1.8	0.5
Ever taken oral contraceptive pill	2.1	2.3	5.2	2.1	-1.3	0.8	-1.0	-1.0	-2.3
Hearing aid user	1.6	1.8	6.6	-0.3	0.4	-2.0	-0.4	-2.6	-0.2
Mother’s age at death	1.6	2.0	3.4	1.6	-1.8	1.4	1.0	0.9	-1.5
Financial situation satisfaction	1.9	2.3	5.6	2.4	-2.2	0.8	0.4	-0.7	-1.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.5	-0.9	1.1	-2.1	-0.5	0.5	0.8
Commuting to job workplace: Public transport	3.7	4.4	8.3	2.6	-2.5	-0.3	-1.8	-1.6	-2.9
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	0.7	-0.5	-0.3	1.1	0.1	-0.7
Medication: Blood pressure	2.6	4.9	8.8	-3.0	3.0	-2.8	-1.1	-0.5	1.7
Pain type(s) experienced in last month: Hip pain	1.3	1.7	4.4	-1.1	0.6	-1.2	2.1	1.2	1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.9	0.9	-1.4	1.1	0.1	0.2	-1.2
High cholesterol (Self-reported)	0.2	0.4	0.8	-0.5	0.7	-0.1	-0.7	0.8	0.9
Medication: Bendroflumethiazide	3.0	4.5	11.9	-2.2	2.4	-3.5	-1.2	0.3	1.8
Medication: Paracetamol	0.6	0.9	4.1	0.4	-0.7	0.7	2.0	-0.1	0.2
Medication: Lisinopril	0.3	0.4	1.1	-0.5	0.6	-0.8	0.2	-0.3	1.0
Medication: Atorvastatin	0.2	0.2	0.7	0.2	-0.0	-0.8	-0.2	0.7	-0.1
Illnesses of father: High blood pressure	2.5	3.1	6.7	-2.5	2.6	-1.6	0.7	-0.8	1.3
Alcohol drinker status: Never	0.3	0.4	0.7	-0.9	0.8	0.2	-0.0	-0.8	0.5
Ever smoked	0.4	0.7	1.3	0.7	-1.1	0.3	1.1	1.1	-0.6
Basal metabolic rate	0.1	0.6	1.0	-1.0	0.8	-1.0	0.3	0.6	0.6
Leg fat percentage (left)	0.4	1.3	5.1	0.5	-0.1	-1.4	0.2	-2.2	-0.9
Arm fat-free mass (left)	0.1	0.5	0.8	-0.9	0.6	-0.2	0.9	0.7	0.8
Number of operations (self-reported)	0.3	0.5	1.4	-0.3	1.0	-0.2	-0.5	1.2	0.5
Average weekly beer plus cider intake	0.9	1.4	3.5	-0.6	1.9	-0.9	-1.5	-1.0	0.4
Irritability	0.4	0.6	2.4	0.5	-0.9	-0.2	-0.1	-1.5	-0.5
Risk taking	3.1	4.5	9.0	-2.1	3.0	-2.3	-2.4	0.7	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	3.0	0.7	-0.5	-1.7	0.1	-1.3	-1.0
Fractured/broken bones in last 5 years	0.6	0.8	2.0	-1.4	1.3	-0.6	0.3	0.2	0.6
Age started oral contraceptive pill	2.4	3.0	6.9	2.6	-2.4	-0.4	1.0	-1.1	-1.7
Diastolic blood pressure, automated reading	2.8	8.5	19.6	-4.2	4.4	-2.2	0.3	0.5	3.0
Ever depressed for a whole week	6.4	7.8	14.0	3.7	-3.4	0.2	-1.5	-2.6	-3.5
Unable to work because of sickness or disability	0.3	0.3	1.4	-0.2	0.6	-0.4	-0.3	-1.2	-0.2
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.9	0.3	-0.3	-1.1	-0.8	-0.6
Myopia	0.8	1.2	4.6	-0.8	-0.2	1.1	0.4	2.2	0.6
Vascular/heart problems diagnosed by doctor	2.7	7.5	16.3	3.4	-3.4	4.0	0.6	-0.3	-2.1
Cholesterol lowering medication	1.6	2.3	4.1	-1.7	1.8	-1.8	-0.2	0.6	2.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.6	1.1	-0.9	-0.4	1.3	-0.9	-1.2
Pain experienced in last month	0.6	1.0	3.7	-0.6	0.7	1.9	-1.1	-0.3	-0.2
Supplements: Calcium	1.0	1.1	3.2	1.4	-1.8	0.4	-0.2	-0.4	-1.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	-0.6	-0.0	0.2	0.4	1.1	0.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	0.3	-0.7	0.2	1.4	0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	-0.9	1.4	0.1	-1.5	-0.0	0.4
Heart disease (siblings)	1.2	1.5	3.9	-0.8	1.4	-0.0	2.0	0.8	1.5
Alcohol drinker status: Previous	0.3	0.3	1.0	0.4	-0.5	-1.0	-0.2	-0.4	-0.5
Pack years of smoking	1.9	2.7	5.0	2.0	-1.7	0.0	-0.6	-2.0	-2.2
Impedance of whole body	1.1	5.5	9.1	3.0	-3.0	0.1	2.5	-1.9	-2.3
Leg fat mass (left)	0.3	1.1	3.9	-0.5	0.7	-2.0	0.3	-1.4	-0.1
Arm predicted mass (left)	0.1	0.3	0.6	-0.8	0.6	-0.1	0.7	0.3	0.6