Hub : Genes

LZTS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Prostate	0.2370	0.0890	7.8e-03	0.052	NA	0.086	NA	0.050	1.9e-02	NA	3.6e-03	NA	2.2e-02
2	GTEx	Testis	0.3020	0.0820	1.8e-04	0.266	NA	0.212	NA	0.248	3.4e-12	NA	8.4e-10	NA	2.2e-11
3	METSIM	Adipose	0.0631	0.0225	7.9e-04	0.015	0.013	0.002	0.014	0.005	2.4e-03	4.4e-03	1.6e-01	2.8e-03	5.6e-02
4	YFS	Blood	0.0587	0.0176	4.2e-05	0.025	0.018	0.032	0.027	0.023	7.5e-09	1.0e-06	1.2e-10	2.5e-09	3.6e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.7	4.0	-0.2	2.0	1.4	-1.0
Bipolar Disorder or Schizophrenia	0.7	1.6	3.4	-0.4	1.8	1.5	0.8
Depressed Affect (Nagel 2018)	0.5	1.0	2.4	-0.7	-1.6	-0.8	-0.8
Depression (Nagel 2018)	1.3	2.0	5.3	-1.3	-0.9	-2.3	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.9	1.3	1.3	1.7	-0.1
Neuroticism (Nagel 2018)	0.5	1.2	2.6	0.0	-1.3	-0.8	-1.6
Schizophrenia (2018)	0.5	1.1	3.0	-0.4	0.7	0.8	1.7
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	-0.7	-1.0	-0.6	0.1
Worry (Nagel 2018)	0.3	0.7	1.1	0.1	-0.7	-1.1	-1.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.3	0.9	1.5	0.0	-0.3
Alzheimer’s Disease (in father)	0.6	0.7	2.3	-0.1	1.5	-0.1	0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	3.2	0.3	1.8	-0.4	-0.2
Crohns Disease (2017)	0.7	1.5	3.4	-0.4	0.7	-1.8	-1.4
Irritable Bowel Disease (IBD)	1.2	2.9	5.6	-0.4	0.9	-2.4	-2.2
Ulcerative Colitis (UC)	0.6	1.1	2.1	-0.8	0.6	-1.4	-1.2
Major Depression (MDD)	0.7	0.8	1.5	-0.4	-1.2	-1.2	-0.5
Reaction Time	0.4	0.8	1.3	-0.5	-0.9	0.9	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.6	1.2	1.2	1.3	0.2
Breast Cancer	0.1	0.2	0.3	-0.5	0.4	0.5	0.1
Ovarian Cancer	0.8	1.0	1.7	-1.3	1.3	-0.3	-0.9
Prostate Cancer	1.1	1.5	3.0	1.1	1.7	1.3	-0.5
Age at First Birth	0.4	0.6	1.2	-1.1	-0.4	-0.6	0.8
Bipolar Disorder (2011)	0.6	0.6	1.1	1.1	1.0	-0.3	-0.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.7	0.5	-0.3	-0.0	1.3
Coronary Artery Disease (CAD)	1.8	2.1	7.4	0.0	-0.9	-2.7	0.5
Crohns Disease (2012)	1.0	1.6	2.7	-0.5	1.1	-1.6	-1.4
Mean Putamen Volume	1.5	1.8	4.6	-0.5	-2.1	-1.5	-0.4
Fasting Glucose	3.7	4.5	7.8	2.5	-1.1	-2.8	-1.7
HbA1C	1.3	1.5	4.7	-0.8	-2.2	0.7	-0.2
HDL Cholesterol	9.0	15.0	37.2	0.1	-1.7	4.5	-6.1
LDL Cholesterol	0.6	1.0	1.8	1.3	-1.1	-0.9	-0.2
Lupus	1.4	2.1	4.2	-0.2	-1.3	2.1	1.5
Neuroticism (2016)	0.2	0.3	0.7	-0.6	-0.8	-0.2	0.4
Primary Biliary Cirrhosis	0.5	0.7	1.7	-0.8	-1.3	0.5	0.4
Rheumatoid Arthritis	0.8	1.1	2.0	0.9	-1.4	1.2	-0.3
Schizophrenia (2014)	0.3	0.7	1.8	0.0	0.4	0.9	1.3
Triglycerides	8.2	13.4	32.9	0.6	-0.9	-5.7	4.4
Type 2 Diabetes (T2D) (2012)	1.8	2.1	5.2	-2.3	0.9	0.8	1.3
Ulcerative Colitis	0.8	1.2	2.0	-1.1	1.4	-1.0	-0.6
Blood Eosinophil Count	0.4	2.9	5.9	-1.5	-2.4	1.2	-1.5
Blood Platelet Count	0.2	1.9	6.9	0.8	-0.4	0.3	-2.6
Blood Red Count	0.1	0.9	1.3	0.4	-1.1	-1.2	0.8
Blood White Count	0.1	1.1	1.7	-1.2	-1.1	0.2	1.3
Heel T-Score	0.3	2.4	5.4	-1.2	2.3	1.6	-0.5
BMI	0.0	0.2	0.8	-0.1	-0.9	0.1	0.4
Height	0.1	1.1	2.8	-0.1	-1.7	0.2	-1.2
Waist Hip Ratio (WHR)	0.1	0.3	0.5	-0.7	0.4	-0.6	0.5
Systolic Blood Pressure	0.0	0.2	0.7	0.8	0.1	-0.1	-0.1
Smoking Status	0.3	0.7	1.3	-0.3	-1.0	0.5	1.2
Allergy or Eczema	1.3	3.3	10.2	3.2	1.4	0.6	-1.0
Cardiovascular Disease	0.5	1.8	5.9	-0.2	0.4	-2.4	-1.1
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.2	-0.4	-0.1	0.2
Respiratory disease	0.3	0.7	1.1	0.9	1.1	0.9	0.4
Type 2 Diabetes (T2D) (2018)	1.8	3.4	7.5	-2.7	-0.0	-2.4	0.5
Lung FEV1/FVC ratio	0.2	0.8	1.6	0.3	-0.7	1.0	1.3
Lung FVC	0.2	0.9	3.1	0.1	1.8	0.0	0.7
Neuroticism	0.3	0.7	1.7	0.3	-0.9	-0.6	-1.3
Chronotype (morning person)	1.1	2.6	5.7	0.1	2.1	2.4	-0.6
Hair Pigment	0.0	0.1	0.1	0.4	-0.1	0.1	0.2
Tanning	0.2	2.0	3.4	1.4	-0.2	1.9	1.5
Hand grip strength (left)	0.4	1.0	3.4	0.7	-0.1	-1.9	-0.1
Number of treatments/medications taken	0.4	0.8	2.6	-0.5	-0.6	-0.1	-1.6
Average weekly spirits intake	0.6	0.8	2.4	0.2	-0.4	-0.8	-1.5
Sensitivity / hurt feelings	1.2	2.0	3.7	-0.1	-0.9	-1.9	-1.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	-0.8	-0.7	-1.4	-1.0
Hearing difficulty/problems: Yes	0.4	0.6	1.0	-0.5	-0.7	1.0	-0.9
Relative age of first facial hair	0.4	0.8	2.5	-0.1	0.7	-1.6	0.5
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.5	0.9	1.2	1.0	0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.1	-0.1	1.4	0.6	-0.4
Ever had hysterectomy (womb removed)	1.5	1.7	3.7	-1.0	-1.9	-0.8	-1.2
Systolic blood pressure, automated reading	0.3	0.9	3.5	1.9	0.2	0.5	0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.8	-1.4	-0.7	-1.1	-0.9
Angina	1.1	1.4	4.5	-0.2	0.5	-2.1	0.9
Medication for hormone replacement therapy	1.5	1.7	4.0	1.3	0.9	0.6	-2.0
Vitamin and mineral supplements	0.8	1.1	2.5	1.6	0.8	-0.2	-1.1
Supplements: Zinc	0.7	0.8	1.2	0.2	-0.9	1.1	1.0
Medication: Co-codamol	0.7	0.8	1.6	-1.3	-1.0	0.5	-0.8
Medication: Metformin	1.5	2.2	6.5	-2.5	-0.6	-1.4	0.3
Diabetes (father)	0.3	0.4	0.5	-0.7	0.6	0.5	0.5
Diabetes (mother)	0.6	0.8	1.8	0.4	-0.9	-1.3	-0.7
Severe depression (siblings)	1.6	1.7	3.7	-0.1	-1.4	1.1	1.9
Pack years adult smoking proportion	0.6	0.9	2.2	0.1	-0.7	1.5	0.9
Impedance of leg (right)	0.1	0.3	0.6	0.8	0.1	0.7	-0.2
Leg fat-free mass (left)	0.1	0.6	0.9	-0.9	-0.9	0.8	0.1
Trunk fat percentage	0.1	0.4	0.6	-0.7	-0.6	0.8	-0.1
Hand grip strength (right)	0.3	0.8	2.0	0.7	-1.4	0.1	0.8
Townsend deprivation index at recruitment	0.6	0.8	1.1	1.0	0.7	-1.1	0.7
Current tobacco smoking	0.6	1.0	2.9	-0.3	-0.2	1.0	1.7
Average weekly fortified wine intake	0.4	0.5	1.0	1.0	0.4	0.9	-0.2
Maternal smoking around birth	0.3	0.4	1.3	-1.1	0.4	0.2	0.2
Fed-up feelings	0.2	0.4	1.0	-0.3	-0.6	0.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.7	0.2	-1.6	-2.2	0.8
Relative age voice broke	0.3	0.4	0.8	0.9	0.0	-0.9	-0.2
Taking other prescription medications	0.7	1.0	3.2	-0.9	0.2	-0.3	-1.8
Age when periods started (menarche)	0.1	0.2	0.6	-0.1	0.1	-0.8	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.8	0.2	0.2	-0.3	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.8	-0.5	1.9	0.2	-1.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.8	0.7	0.8	0.3	-0.9
Qualifications: CSEs or equivalent	0.5	0.6	1.2	-0.8	-1.1	0.7	0.4
Serious illness, injury or assault to yourself	0.0	0.1	0.2	0.1	-0.2	-0.4	0.0
High blood pressure	0.4	1.2	1.8	0.1	1.3	-1.2	-1.3
Hayfever, allergic rhinitis or eczema	1.2	2.7	9.1	3.0	1.0	0.7	-0.5
Multivitamins +/- minerals	0.7	1.0	1.5	-1.2	-1.1	-0.3	1.1
Stomach or abdominal pain in last month	0.4	0.5	1.1	-1.1	-0.8	-0.6	0.1
Supplements: Glucosamine	0.7	0.9	2.2	0.3	1.5	0.9	0.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.7	-1.6	1.5	-0.1	0.0
Medication: Atenolol	2.1	2.7	5.5	-1.6	-0.0	-2.3	-1.6
Medication: Levothyroxine sodium	0.3	0.6	1.7	0.3	0.1	0.6	1.3
Sitting height	0.1	0.4	0.8	0.9	0.2	-0.8	-0.4
Chronic bronchitis/emphysema (father)	1.4	1.6	2.7	1.5	-1.2	0.4	-1.6
High blood pressure (mother)	0.2	0.3	1.0	-0.2	0.1	-0.3	1.0
Body mass index (BMI)	0.1	0.5	0.9	-1.0	-0.3	0.7	-0.6
Impedance of leg (left)	0.1	0.3	0.7	0.7	-0.3	0.8	-0.1
Leg predicted mass (left)	0.1	0.7	1.0	-1.0	-1.0	0.8	0.1
Trunk fat mass	0.1	0.6	0.8	-0.8	-0.9	0.9	-0.2
Waist circumference	0.2	0.8	1.6	-1.3	-0.7	1.1	-0.1
Number of incorrect matches in round	0.8	1.3	2.0	-1.3	-0.9	-1.4	-0.7
Past tobacco smoking	0.6	1.0	2.4	0.8	1.5	-0.3	-1.0
Alcohol usually taken with meals	1.1	1.8	4.5	-0.7	-0.8	1.3	2.1
Nervous feelings	0.5	1.0	2.4	0.2	-0.3	-1.2	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	0.5	-0.8	0.6	-0.6
Hearing difficulty/problems with background noise	0.5	0.8	2.4	-0.4	0.8	1.6	0.1
Hair/balding pattern: Pattern 2	1.4	1.8	6.1	-0.4	0.3	-2.5	1.0
Had menopause	0.2	0.2	0.4	-0.5	-0.2	-0.5	0.7
Had other major operations	0.8	1.0	3.5	-1.9	0.5	-0.2	-0.1
Forced vital capacity (FVC)	0.1	0.4	1.4	-0.4	0.4	0.1	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.5	-0.5	2.3	-0.2	-1.0
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.1	-1.4	-1.6	0.1	-1.8
Qualifications: None of the above	2.0	4.2	7.8	0.1	-2.7	-1.4	-2.8
Financial difficulties in last 2 years	0.4	0.5	1.5	-0.5	-0.4	-1.2	0.3
Mouth/teeth dental problems	0.5	0.8	2.4	1.5	-0.1	0.8	0.6
Heart attack	0.3	0.4	1.0	-1.0	-0.5	-0.3	0.7
Allergy	1.0	2.3	5.3	-2.3	-1.4	-1.3	0.7
Pain all over the body in last month	0.1	0.1	0.2	-0.0	0.3	-0.4	-0.2
Diabetes (self-reported)	1.2	1.8	3.8	-1.9	-0.8	-1.7	-0.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	4.6	2.2	-1.4	0.6	-0.0
Medication: Ramipril	1.3	1.6	3.2	-1.4	-1.1	-0.5	-1.8
Medication: Simvastatin	0.8	1.2	3.2	-1.1	-0.3	-1.8	-0.3
Fluid intelligence score	1.1	2.2	3.7	0.8	1.9	1.9	1.0
Illnesses of siblings	0.7	1.0	3.5	0.4	-0.4	1.9	0.3
Neuroticism score	0.6	1.3	2.4	0.4	-1.6	-0.5	-1.5
Weight	0.2	0.8	1.4	-0.9	-0.8	1.2	-0.5
Impedance of arm (right)	0.2	0.9	2.4	0.8	0.8	0.1	1.5
Arm fat percentage (right)	0.1	0.2	0.8	-0.9	-0.2	0.2	-0.2
Trunk fat-free mass	0.1	0.7	1.0	-0.8	-0.8	1.0	-0.6
Hip circumference	0.2	0.7	2.0	-0.9	-0.2	1.4	-0.2
Time employed in main current job	0.2	0.3	0.4	0.6	0.5	-0.3	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.5	0.2	-0.5	0.2
Father’s age at death	1.0	1.3	4.7	0.7	0.3	2.2	-0.0
Worrier / anxious feelings	0.3	0.5	1.8	-0.1	-1.4	0.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.4	-0.5	-0.3	-0.0
Falls in the last year	0.9	1.2	3.7	0.9	-0.2	1.9	0.6
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	-0.0	-1.3	0.5	-1.2
Number of live births	0.6	0.8	1.5	-1.2	0.0	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.5	-0.4	0.7	0.3	1.2
Pulse rate	0.9	1.5	3.2	-1.5	-0.0	-1.8	-0.6
Happiness	1.2	1.5	2.2	-1.5	-0.9	-0.8	-1.5
Noisy workplace	1.3	1.6	4.2	-2.1	1.1	0.2	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.6	0.4	0.7	1.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.8	-0.2	0.2	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-0.6	-0.6	-0.1	-1.1
Asthma	0.8	1.5	4.2	0.7	1.1	2.0	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.6	1.4	-1.9	-0.1	1.5
Medication: Cholesterol lowering	1.0	1.5	2.4	-1.5	-0.3	-1.5	1.1
Depression (self-reported)	0.4	0.5	1.6	-0.2	-0.5	1.3	-0.1
Medication: Lansoprazole	0.6	0.7	2.1	0.6	1.5	-0.4	-0.2
Prospective memory result	2.0	2.5	5.6	-1.1	0.0	-2.4	-1.8
Lung cancer (father)	0.4	0.4	0.9	-0.7	1.0	-0.6	-0.1
Illnesses of mother	1.3	1.6	3.1	-1.2	-1.3	-0.2	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.8	-0.5	1.2	0.3	1.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	-0.5	-0.3	-0.7	-0.7
Impedance of arm (left)	0.2	1.0	2.2	0.2	1.3	-0.2	1.5
Arm fat mass (right)	0.1	0.5	1.1	-0.8	-0.6	1.0	-0.2
Trunk predicted mass	0.1	0.7	1.1	-0.9	-0.6	1.1	-0.6
Standing height	0.1	0.5	1.4	-0.0	-0.9	1.2	-0.0
Length of working week for main job	1.2	1.3	4.0	-2.0	0.6	0.5	0.8
Exposure to tobacco smoke at home	0.7	0.8	1.5	-1.1	0.3	0.5	1.2
Breastfed as a baby	1.7	2.1	7.2	0.9	-2.7	-0.0	0.7
Tense / ‘highly strung’	0.9	1.4	3.6	1.9	-0.5	0.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.9	0.0	0.2	-0.1	-2.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	0.1	0.3	0.2	-1.1
Birth weight of first child	0.1	0.2	0.6	0.3	-0.1	0.4	-0.8
Peak expiratory flow (PEF)	1.1	2.5	5.4	-0.7	0.7	2.3	1.9
Pulse wave reflection index	0.2	0.2	0.8	-0.3	0.1	-0.1	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	0.1	-0.3	0.5	-0.8
Loud music exposure frequency	2.2	2.4	3.9	1.4	1.9	0.3	-2.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.1	0.2	0.2	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	0.2	1.2	-1.2	0.5
Blood clot in the leg (DVT)	0.6	0.8	3.3	-0.2	-0.1	-1.8	0.1
Medication: Paracetamol	0.9	1.5	4.4	-2.1	-0.4	1.1	0.2
Headache pain in last month	0.4	0.7	1.2	-0.9	-1.1	0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.0	1.0	0.1	0.7	0.3
Glaucoma (self-reported)	0.8	0.9	1.7	-1.3	-0.5	1.3	-0.3
Gout (self-reported)	0.6	0.9	2.6	-0.9	1.6	-0.3	-0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.1	-0.1	-0.9	0.9	1.0
Medication: Amlodipine	0.2	0.3	0.8	0.1	-0.9	0.1	0.6
Medication: Ventolin 100micrograms inhaler	1.3	1.6	4.6	1.2	-2.1	0.7	-0.2
Birth weight	0.7	1.6	3.3	0.8	1.3	-1.8	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.7	1.3	0.4	-0.3	0.1
High blood pressure (siblings)	0.4	0.6	1.2	-0.7	1.1	-0.8	0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.4	-0.2	1.1	0.1	1.2
Body fat percentage	0.1	0.5	1.0	-1.0	-0.6	0.6	-0.5
Leg fat percentage (right)	0.2	0.8	1.6	-1.2	-0.6	0.5	-1.0
Arm fat-free mass (right)	0.2	1.0	1.5	-0.8	-1.2	1.1	-0.8
Exposure to tobacco smoke outside home	1.5	2.0	6.2	-1.1	-0.2	0.6	-2.5
Comparative body size at age 10	0.2	0.4	1.2	1.1	0.6	0.1	0.5
Number of full brothers	0.1	0.2	0.3	-0.4	0.6	0.3	0.2
Worry too long after embarrassment	0.3	0.5	1.7	0.4	-0.4	0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.6	-0.3	0.9	0.2
Wheeze or whistling in the chest in last year	0.9	1.6	3.3	0.3	-1.7	0.3	-1.8
Number of children fathered	2.4	2.7	4.3	2.1	1.8	1.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	7.7	-2.8	0.7	-0.0	1.4
Age at first live birth	0.8	1.4	3.6	0.6	-0.7	1.0	1.9
Pulse wave peak to peak time	0.4	0.5	0.8	0.7	0.2	0.8	0.9
Health satisfaction	1.2	1.6	2.9	-1.7	-0.9	-1.4	0.8
Shortness of breath walking on level ground	1.0	1.2	2.5	-0.0	-1.6	-0.4	-1.4
Qualifications: College or University degree	1.3	4.0	9.5	0.1	2.1	1.5	3.1
Eye problems/disorders: None of the above	0.5	0.6	1.7	1.3	-0.3	-0.0	0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.6	-0.1	0.8	0.0	-0.2
Emphysema/chronic bronchitis	0.9	1.0	2.9	-1.7	-0.3	-0.8	0.5
Medication for pain relief, constipation, heartburn	1.2	2.0	4.9	1.7	2.2	0.4	0.2
Neck or shoulder pain in last month	1.1	1.5	2.6	-1.6	0.5	-1.1	-1.5
Medication: Blood pressure	0.0	0.1	0.1	-0.3	0.3	-0.2	-0.3
Angina (self-reported)	1.0	1.4	4.9	-0.1	0.4	-2.2	0.6
Migraine (self-reported)	1.0	1.3	2.5	-0.1	-0.8	1.4	1.6
Medication: Ibuprofen	1.6	1.9	4.4	1.4	-2.1	-0.8	0.7
Medication: Allopurinol	1.5	2.0	3.9	-0.9	1.6	-2.0	-0.9
Medication: Omeprazole	1.2	1.5	3.0	-1.7	-1.4	0.5	-0.8
Medication: Seretide 50 evohaler	0.6	0.6	1.2	1.1	0.4	1.0	-0.4
Mean time to correctly identify matches	0.3	0.6	1.8	-0.5	-1.3	-0.5	-0.1
Heart disease (mother)	0.9	1.0	3.6	-0.1	1.9	0.2	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	-0.3	-0.3	-1.2	-0.1
Whole body fat mass	0.2	1.0	1.4	-1.1	-1.2	1.0	-0.4
Leg fat mass (right)	0.3	1.1	1.6	-1.3	-1.2	0.9	-0.9
Arm predicted mass (right)	0.2	0.8	1.2	-0.7	-1.1	0.9	-0.9
Pulse rate, automated reading	0.4	1.3	3.3	-1.4	0.1	-1.8	-0.0
Alcohol intake frequency.	0.8	2.0	3.1	1.2	-1.8	1.7	0.7
Comparative height size at age 10	0.6	3.3	8.8	-1.4	-3.0	-1.4	-0.6
Number of full sisters	1.4	1.7	3.7	1.9	-0.4	1.3	1.1
Suffer from ‘nerves’	0.3	0.4	1.0	-0.4	-0.8	-1.0	-0.0
Overall health rating	0.5	1.0	2.0	-0.2	-1.3	-0.7	-1.4
Chest pain or discomfort	0.2	0.4	0.8	0.4	0.7	-0.1	-0.9
Had major operations	2.1	2.5	7.1	-0.6	-0.7	-2.7	-1.4
Age at last live birth	0.5	0.7	1.3	1.1	-1.1	0.1	0.7
Family relationship satisfaction	0.3	0.4	0.8	-0.3	-0.9	-0.9	-0.3
Leg pain on walking	0.2	0.3	0.5	-0.7	-0.5	-0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	7.0	0.7	2.7	-1.5	-0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.2	0.3	-1.5	-1.3	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.0	-0.4	-0.0	-0.8
Medication: Aspirin	1.5	2.0	3.5	-1.9	-1.3	-0.8	1.3
Supplements: Vitamin C	0.4	0.5	1.4	-1.2	0.0	-0.7	-0.5
Knee pain experienced in last month	1.3	2.0	3.6	-1.4	1.9	1.5	-0.3
Hypertension (Self-reported)	0.6	1.7	3.0	0.0	1.5	-1.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.8	-0.9	0.4	0.0
Illnesses of father: Heart disease	0.9	1.2	2.9	-0.7	1.7	-1.2	0.2
Illnesses of siblings: Diabetes	2.7	3.4	7.1	-0.2	-2.7	-2.4	-0.8
Smoking status: Previous	0.5	0.8	2.8	-0.4	-1.7	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.5	-0.1	-0.4	2.3	0.6
Whole body fat-free mass	0.1	0.8	1.2	-1.1	-0.9	1.1	-0.4
Leg fat-free mass (right)	0.1	0.7	1.0	-1.0	-1.0	1.0	0.1
Arm fat percentage (left)	0.1	0.4	1.4	-1.2	-0.3	0.2	0.1
Average weekly red wine intake	1.7	2.5	4.4	-0.3	1.7	1.5	2.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.4	-0.0	-0.5	-0.1
Mood swings	0.1	0.2	0.6	-0.1	-0.8	0.2	-0.1
Loneliness, isolation	0.7	1.0	3.8	0.3	-1.9	0.0	0.5
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-0.4	0.8	0.5	-1.0
Ever had bowel cancer screening	0.2	0.2	0.7	0.2	-0.3	-0.8	-0.5
Diabetes diagnosed by doctor	1.5	2.4	5.9	-2.4	0.0	-1.8	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.0	-0.7	-0.1	1.0	0.7
Friendships satisfaction	2.4	2.9	5.8	-2.2	-2.4	-0.0	1.1
Qualifications: nursing, teaching	0.5	0.8	2.7	0.2	1.6	0.5	-0.2
Commuting to job workplace: Walk	1.0	1.0	2.4	0.9	1.6	0.8	0.3
Eye problems/disorders: Cataract	0.5	0.5	0.8	0.8	-0.9	-0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.8	-0.9	-0.2	-0.0	1.3
Medication for cholesterol	0.8	1.1	3.8	0.6	-0.4	0.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.4	1.0	-1.1	1.2	-0.2
Back pain experienced in last month	0.4	0.6	1.5	-0.7	0.1	-0.5	-1.2
Mineral and other dietary supplements	0.4	0.6	2.1	0.2	-1.5	-0.2	-0.1
Breast cancer (self-reported)	1.2	1.5	1.9	1.2	-1.1	-1.1	-1.4
Asthma (self-reported)	0.8	1.7	4.8	0.6	1.2	2.2	0.0
Osteoporosis (self-reported)	0.7	0.8	1.5	1.2	-0.6	-0.8	-0.8
Osteoarthritis (self-reported)	0.9	1.2	3.5	-0.3	1.2	-0.2	-1.9
Medication: Aspirin	2.1	2.7	5.6	-2.4	-1.4	-1.3	1.2
Medication: Gliclazide	0.5	0.6	1.1	-1.0	0.3	-0.5	-1.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	0.1	-0.9	-0.3	-0.3
Smoking status: Current	0.6	0.9	2.9	-0.5	-0.1	0.8	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.3	1.4	1.0	0.7	1.5
Whole body water mass	0.1	0.7	1.0	-1.0	-0.9	0.9	-0.5
Leg predicted mass (right)	0.1	0.7	1.0	-1.0	-0.9	1.0	0.0
Arm fat mass (left)	0.1	0.6	1.1	-1.0	-0.5	1.0	-0.0
Number of self-reported non-cancer illnesses	0.7	1.1	2.7	-0.1	1.2	0.6	-1.6
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.4	0.7	0.5	0.2
Miserableness	0.8	1.3	2.1	-0.4	-1.4	-1.4	-1.1
Guilty feelings	0.3	0.4	1.2	-0.6	0.3	-0.2	-1.1
Wears glasses or contact lenses	0.5	0.6	1.1	0.2	-1.0	-0.6	-0.9
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.6	-0.4	-0.5	0.2
Hearing aid user	0.0	0.0	0.1	0.2	0.3	-0.2	-0.2
Mother’s age at death	0.8	1.0	1.8	-0.7	-0.2	1.4	1.2
Financial situation satisfaction	1.1	1.4	2.8	-1.7	-0.5	0.7	1.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.9	-0.9	0.5	-0.3
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.5	0.1	0.1	-0.7
Eye problems/disorders: Glaucoma	1.4	1.6	5.7	-2.4	0.1	0.6	-0.6
Medication: Blood pressure	1.7	3.2	5.9	-1.8	0.1	-2.4	-1.9
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.5	-1.9	1.6	0.6	0.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.1	-0.0	2.3	0.2	0.4
High cholesterol (Self-reported)	0.8	1.5	4.8	-0.6	-0.6	-2.2	0.5
Medication: Bendroflumethiazide	1.7	2.6	4.7	0.6	-1.1	-2.2	-2.0
Medication: Paracetamol	0.9	1.4	4.9	-2.2	-0.3	0.6	0.3
Medication: Lisinopril	1.0	1.3	2.2	1.4	1.0	-1.5	-0.1
Medication: Atorvastatin	1.5	1.8	5.3	-2.3	0.6	-0.6	1.2
Illnesses of father: High blood pressure	0.9	1.1	3.8	-1.9	0.2	0.8	-0.4
Alcohol drinker status: Never	0.4	0.5	1.7	-0.0	-0.6	1.3	-0.1
Ever smoked	1.1	1.9	4.3	-1.3	-1.2	0.6	2.1
Basal metabolic rate	0.2	1.0	1.6	-1.0	-1.1	1.3	-0.3
Leg fat percentage (left)	0.3	0.9	1.8	-1.4	-0.8	0.6	-1.0
Arm fat-free mass (left)	0.2	1.1	2.4	-0.6	-1.0	1.6	-0.8
Number of operations (self-reported)	1.6	2.4	4.5	-1.9	0.1	-2.1	-1.2
Average weekly beer plus cider intake	0.4	0.6	1.1	-1.1	-0.7	-1.0	0.1
Irritability	1.0	1.7	3.3	1.8	-1.3	0.2	-1.3
Risk taking	1.3	1.9	3.1	0.8	1.1	1.8	1.7
Ever had prostate specific antigen (PSA) test	2.8	3.2	5.9	-1.0	-2.4	-1.9	-1.6
Fractured/broken bones in last 5 years	0.4	0.5	1.0	-0.2	-0.9	-1.0	-0.2
Age started oral contraceptive pill	0.2	0.3	0.6	-0.3	-0.7	0.0	0.8
Diastolic blood pressure, automated reading	0.1	0.4	1.1	1.0	-0.2	-0.5	-0.3
Ever depressed for a whole week	1.3	1.6	2.0	-1.0	-1.4	-1.2	-1.4
Unable to work because of sickness or disability	0.9	1.2	3.1	1.8	-1.0	-0.8	-0.3
Commuting to job workplace: Cycle	0.4	0.4	1.1	0.0	0.5	1.0	0.6
Myopia	0.3	0.4	0.8	0.5	0.5	-0.5	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.7	-0.3	-1.0	1.3	1.1
Cholesterol lowering medication	1.8	2.6	5.0	-2.2	-0.8	-2.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	4.1	-1.6	-2.0	1.0	-0.3
Pain experienced in last month	1.5	2.5	8.9	3.0	-0.8	-0.4	0.5
Supplements: Calcium	1.1	1.2	2.9	1.7	-0.9	0.9	0.7
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	0.7	0.6	-0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	-1.1	-0.4	-0.3	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.4	-0.0	-0.0	-1.6	0.4
Heart disease (siblings)	0.6	0.7	1.1	-0.6	-0.9	-1.0	0.8
Alcohol drinker status: Previous	1.1	1.3	3.7	0.6	0.2	1.0	1.9
Pack years of smoking	0.3	0.4	0.8	0.1	-0.9	0.8	0.3
Impedance of whole body	0.1	0.4	0.8	0.5	0.9	0.5	0.6
Leg fat mass (left)	0.3	1.2	1.7	-1.2	-1.3	0.9	-0.9
Arm predicted mass (left)	0.2	0.9	2.0	-0.6	-0.8	1.4	-0.8