TWAS hub - LZTS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.265	0.1020	0.00650	-0.001	NA	0.006	NA	0.017	3.5e-01	NA	0.21000	NA	1.0e-01
2	TCGA	Breast Invasive Carcinoma	0.021	0.0093	0.00018	0.026	0.019	0.017	NA	0.021	3.3e-06	8e-05	0.00016	NA	3.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Current tobacco smoking	7.7	12.6	20.4	-2.2	4.5
Smoking status: Current	7.1	11.3	18.8	-1.9	4.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.2	10.9	20.6	1.1	-4.5
Age at First Birth	4.7	6.8	12.7	1.0	-3.6
Comparative height size at age 10	4.6	25.1	49.7	0.6	7.0
Maternal smoking around birth	4.4	6.3	11.7	-1.0	3.4
Back pain experienced in last month	3.9	5.7	8.1	-2.8	1.8
Hearing difficulty/problems: Yes	3.8	5.9	6.3	2.3	2.5
Relative age voice broke	3.5	5.4	8.6	-1.5	-2.9
Pulse rate, automated reading	3.5	11.2	22.1	4.7	0.6
Smoking Status	3.4	8.0	15.0	-1.1	3.9
Chronic bronchitis/emphysema (father)	3.1	3.6	5.6	-1.2	2.4
Loud music exposure frequency	3.1	3.4	6.5	-0.4	2.6
Supplements: Zinc	2.9	3.2	5.9	0.7	2.4
Health satisfaction	2.8	3.7	7.2	2.7	0.5
Exposure to tobacco smoke outside home	2.7	3.6	6.7	-0.7	2.6
Hand grip strength (left)	2.6	6.8	7.9	2.8	2.4
Relative age of first facial hair	2.6	5.4	10.6	-0.5	-3.3
Type 2 Diabetes (T2D) (2012)	2.5	2.9	4.0	2.0	1.3
Pack years adult smoking proportion	2.5	3.8	5.0	-1.6	2.2
Body Mass Index (BMI) (2010)	2.4	3.2	6.4	-0.2	-2.5
Serious illness, injury or assault to yourself	2.4	2.9	5.6	2.4	-0.5
Financial difficulties in last 2 years	2.3	3.1	4.0	-2.0	1.5
Exposure to tobacco smoke at home	2.3	2.5	4.5	-2.1	-0.8
Asthma (self-reported)	2.3	4.6	9.1	0.3	3.0
Asthma	2.2	4.2	8.4	0.3	2.9
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	5.3	-0.5	2.3
Irritability	2.1	3.5	4.6	1.6	2.1
Wheeze or whistling in the chest in last year	2.0	3.6	6.9	-0.4	2.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	2.9	-1.4	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.4	-0.5	-2.1
Leg fat-free mass (right)	2.0	10.7	19.4	1.4	4.4
Leg predicted mass (right)	2.0	10.9	20.0	1.3	4.5
Pack years of smoking	2.0	3.0	3.5	-1.6	1.9
Diabetes (mother)	1.9	2.4	4.8	2.2	0.3
Leg fat-free mass (left)	1.9	10.1	18.4	1.3	4.3
Leg predicted mass (left)	1.9	10.3	18.9	1.3	4.3
Alcohol usually taken with meals	1.9	3.1	3.7	-1.9	-1.6
Age at first live birth	1.9	3.4	6.8	-0.1	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.1	-1.8	0.9
Friendships satisfaction	1.9	2.4	4.3	2.1	0.6
Medication: Paracetamol	1.9	3.0	3.3	-1.8	1.6
Hand grip strength (right)	1.8	4.9	5.6	2.0	2.4
Family relationship satisfaction	1.8	2.2	4.4	2.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.6	4.0	1.8	2.0
Whole body water mass	1.8	10.2	19.9	0.7	4.5
Sitting height	1.7	12.0	21.7	1.5	4.7
Hearing difficulty/problems with background noise	1.7	2.8	5.3	2.3	0.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.8	2.2	-0.8
Birth weight	1.7	3.6	7.2	2.7	-0.1
Medication: Seretide 50 evohaler	1.7	2.0	3.9	-0.3	2.0
Whole body fat-free mass	1.7	9.7	19.0	0.6	4.4
Trunk fat-free mass	1.6	9.4	18.7	0.2	4.3
Depression (self-reported)	1.6	1.9	3.7	0.4	1.9
Trunk predicted mass	1.6	9.1	18.1	0.2	4.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	2.3	-1.4	-1.5
Medication: Paracetamol	1.6	2.6	2.7	-1.6	1.6
Ever had bowel cancer screening	1.6	1.9	2.0	1.4	-1.3
Basal metabolic rate	1.6	8.6	16.5	0.9	4.1
Heart disease (siblings)	1.6	2.0	3.8	-1.9	-0.5
Mean Putamen Volume	1.5	1.7	1.9	1.4	-1.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.8	1.7	-0.8
Diabetes (father)	1.5	1.9	3.3	1.8	0.7
Age when periods started (menarche)	1.5	3.6	6.3	0.9	-2.5
Fluid intelligence score	1.5	3.2	5.1	1.1	2.3
Happiness	1.5	1.8	3.4	1.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.4	-0.2	-1.9
Arm fat-free mass (right)	1.5	7.5	15.0	0.3	3.9
Had major operations	1.5	1.7	3.4	1.8	-0.3
Age started oral contraceptive pill	1.5	1.8	1.9	1.3	-1.4
High blood pressure (mother)	1.4	2.0	2.1	1.4	-1.4
Number of incorrect matches in round	1.4	2.4	4.4	-2.1	0.6
Alcohol intake versus 10 years previously	1.4	2.1	3.2	-1.0	1.8
Mother’s age at death	1.4	1.7	3.4	1.8	-0.2
Illnesses of father: High blood pressure	1.4	1.7	3.3	-0.1	-1.8
Arm fat-free mass (left)	1.4	7.1	13.9	0.5	3.7
Arm predicted mass (left)	1.4	7.0	13.9	0.3	3.7
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.4	-1.6	0.7
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	2.7	0.7	-1.6
Impedance of leg (left)	1.3	6.2	10.3	-1.5	-3.2
Qualifications: None of the above	1.3	2.7	5.1	-2.3	0.5
Heart attack	1.3	1.6	3.2	-1.8	0.2
Pain all over the body in last month	1.3	1.4	1.6	1.1	1.3
Medication: Ramipril	1.3	1.6	2.4	1.6	0.9
Tense / ‘highly strung’	1.3	2.1	4.0	-2.0	0.5
Medication: Blood pressure	1.3	2.3	4.6	0.2	-2.1
Arm predicted mass (right)	1.3	6.5	12.9	0.2	3.6
Basal cell carcinoma (self-reported)	1.3	1.6	2.9	1.7	0.5
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.0	0.5	1.7
Alzheimer’s Disease (in mother)	1.2	1.3	2.3	-0.6	-1.5
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.2	1.3	2.1
Height	1.2	23.5	44.4	1.6	6.7
Respiratory disease	1.2	2.7	5.2	0.5	2.3
Medication: Metformin	1.2	1.7	2.7	1.6	0.9
Impedance of leg (right)	1.2	5.8	9.4	-1.5	-3.1
Average weekly fortified wine intake	1.2	1.4	2.7	1.6	-0.3
Standing height	1.2	11.6	20.5	1.6	4.5
Blood clot in the leg (DVT)	1.2	1.6	2.9	0.6	1.7
Suffer from ‘nerves’	1.2	1.9	3.7	-0.0	-1.9
Diastolic blood pressure, automated reading	1.2	3.8	4.7	1.7	-2.2
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.0	-1.7	0.3
Lupus	1.1	1.7	2.8	-1.7	0.7
Nervous feelings	1.1	2.1	2.4	1.4	-1.6
Hair/balding pattern: Pattern 2	1.1	1.3	1.9	0.9	-1.4
Allergy	1.1	2.5	4.3	-0.8	-2.1
Worrier / anxious feelings	1.1	2.0	4.0	-0.1	-2.0
Medication: Amlodipine	1.1	1.6	3.1	0.3	-1.8
Average weekly beer plus cider intake	1.1	1.6	2.9	-1.7	-0.6
Coronary Artery Disease (CAD)	1.0	1.2	1.9	-0.7	-1.4
Sensitivity / hurt feelings	1.0	1.6	3.2	-0.2	-1.8
Gout (self-reported)	1.0	1.4	2.6	-0.4	1.6
Migraine (self-reported)	1.0	1.2	2.4	0.2	-1.5
Pain type(s) experienced in last month: Hip pain	1.0	1.3	1.8	-1.4	0.9
Alzheimer’s Disease (in father)	0.9	1.0	2.0	1.4	-0.1
Blood Platelet Count	0.9	10.9	12.0	3.1	-3.5
Heel T-Score	0.9	6.9	7.9	-2.4	-2.8
Medication: Co-codamol	0.9	1.0	1.4	-0.8	1.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.6	-1.3	-0.5
Qualifications: CSEs or equivalent	0.9	1.2	2.1	-1.5	0.6
Multivitamins +/- minerals	0.9	1.2	2.3	0.0	-1.5
Medication: Atenolol	0.9	1.1	1.8	-0.7	1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.3	1.5	-1.1
Comparative body size at age 10	0.9	2.4	3.7	-1.9	1.0
Alcohol intake frequency.	0.9	2.0	3.7	-0.6	1.9
Number of full sisters	0.9	1.1	2.2	1.5	-0.2
Age at last live birth	0.9	1.3	2.2	-0.6	-1.5
Mood swings	0.9	1.5	2.8	-0.5	1.7
Medication: Atorvastatin	0.9	1.1	1.8	-1.4	0.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	-1.4	0.3
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.9	2.2	0.5
Neuroticism (2016)	0.8	1.2	1.3	1.1	-1.0
Primary Biliary Cirrhosis	0.8	1.2	1.9	-0.7	-1.4
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.5	-1.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.5	1.2	0.8
High blood pressure	0.8	2.1	3.8	0.7	-1.9
Weight	0.8	3.9	6.4	1.2	2.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.0	1.7	0.8
Mouth/teeth dental problems: Dentures	0.8	1.3	1.9	1.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	-1.1	0.8
Medication: Lansoprazole	0.8	1.0	1.4	-0.7	-1.2
Birth weight of first child	0.8	1.4	1.9	1.4	-1.0
Glaucoma (self-reported)	0.8	1.0	1.7	-1.3	-0.5
Emphysema/chronic bronchitis	0.8	0.9	1.9	0.1	1.4
Angina (self-reported)	0.8	1.0	1.2	-0.9	1.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	0.2	-1.4
Hypertension (Self-reported)	0.8	2.4	4.6	0.4	-2.1
Average weekly red wine intake	0.8	1.1	2.2	0.1	-1.5
Commuting to job workplace: Walk	0.8	0.8	1.3	1.1	-0.6
Hearing aid user	0.8	0.9	1.4	1.2	0.5
Ever smoked	0.8	1.3	2.7	-0.1	1.6
Ever depressed for a whole week	0.8	1.0	1.8	-1.4	0.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.0	0.2	-1.4
Bipolar Disorder (2011)	0.7	0.7	1.0	1.0	0.6
Hypothyroidism (self reported)	0.7	1.7	3.2	1.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	1.7	1.0	1.3
Vitamin and mineral supplements	0.7	1.0	1.8	-0.3	1.4
Severe depression (siblings)	0.7	0.8	0.9	0.8	1.0
Medication: Levothyroxine sodium	0.7	1.2	2.2	1.5	-0.5
Past tobacco smoking	0.7	1.3	2.6	-0.1	-1.6
Illnesses of siblings	0.7	0.9	1.4	1.2	0.6
Pulse rate	0.7	1.2	2.3	1.5	0.4
Lung cancer (father)	0.7	0.9	1.0	1.0	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	0.8	1.3
Medication: Allopurinol	0.7	0.9	1.8	-0.1	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.1	1.1	0.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	-1.1	-0.6
Eye problems/disorders: Glaucoma	0.7	0.8	1.2	-1.1	0.6
Alcohol drinker status: Previous	0.7	0.8	1.5	-0.1	1.2
Depression (Nagel 2018)	0.6	1.0	1.9	1.4	-0.3
Breast Cancer	0.6	1.5	2.9	-0.3	1.7
Neuroticism	0.6	1.4	1.9	1.4	-0.9
Angina	0.6	0.8	1.2	-0.6	1.1
Had menopause	0.6	0.7	1.2	0.5	-1.1
Noisy workplace	0.6	0.7	1.4	-0.0	1.2
Impedance of arm (left)	0.6	2.6	2.9	1.5	-1.7
Number of children fathered	0.6	0.7	1.0	-1.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.0	0.6	-1.0
Medication: Ibuprofen	0.6	0.8	1.3	-1.1	0.5
Illnesses of father: None of the above (group 1)	0.6	0.8	0.9	-0.8	-0.9
Average weekly champagne plus white wine intake	0.6	0.8	0.8	-0.9	-0.9
Miserableness	0.6	1.0	1.4	0.8	1.2
Medication: Bendroflumethiazide	0.6	0.9	1.8	1.3	-0.1
Impedance of whole body	0.6	3.2	6.4	0.0	-2.5
HDL Cholesterol	0.5	0.8	1.6	-0.3	1.3
Lung FEV1/FVC ratio	0.5	2.5	4.1	-0.9	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	0.1	-1.5
Supplements: Glucosamine	0.5	0.6	0.8	-0.7	-0.9
Illnesses of mother	0.5	0.6	1.0	-0.4	1.0
Headache pain in last month	0.5	0.8	1.2	0.6	1.1
High blood pressure (siblings)	0.5	0.8	1.5	-0.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-0.9	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.0	1.0	0.3
Breast cancer (self-reported)	0.5	0.6	0.7	0.9	0.7
Medication: Lisinopril	0.5	0.7	1.0	-1.0	-0.6
Risk taking	0.5	0.7	1.3	-1.2	0.2
Commuting to job workplace: Cycle	0.5	0.7	1.1	1.0	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.7	-0.1	1.6
Pain experienced in last month	0.5	0.8	1.1	1.1	-0.6
Schizophrenia (2018)	0.4	0.9	1.0	0.9	-1.0
Ovarian Cancer	0.4	0.6	0.9	-0.5	-0.9
HbA1C	0.4	0.4	0.5	-0.7	0.6
LDL Cholesterol	0.4	0.6	1.1	-1.1	-0.1
Triglycerides	0.4	0.7	1.3	0.3	-1.1
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.1	0.9
Fed-up feelings	0.4	0.8	1.1	1.0	0.7
Taking other prescription medications	0.4	0.6	1.0	-1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.4	1.2	0.6
Had other major operations	0.4	0.4	0.9	-0.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.0	0.6	1.0
Number of live births	0.4	0.5	1.0	-1.0	0.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.0	1.0
Breastfed as a baby	0.4	0.4	0.5	0.7	-0.6
Leg fat percentage (right)	0.4	1.3	2.6	-0.2	-1.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	-0.3
Medication: Omeprazole	0.4	0.5	1.0	1.0	0.1
Chest pain or discomfort	0.4	0.5	1.0	0.1	1.0
Leg pain on walking	0.4	0.5	1.0	-0.2	1.0
Supplements: Vitamin C	0.4	0.5	0.5	-0.7	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	0.7	0.8	-0.6
Loneliness, isolation	0.4	0.6	0.9	0.9	-0.6
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.2	1.0
Medication: Gliclazide	0.4	0.4	0.8	0.3	0.9
Arm fat mass (left)	0.4	1.7	1.8	1.4	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.9	0.4	1.0
Blood White Count	0.3	1.9	2.4	-1.6	-1.2
Waist Hip Ratio (WHR)	0.3	1.3	2.1	-1.5	-0.7
Cardiovascular Disease	0.3	0.9	1.7	-0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.7	0.8	-0.0
Trunk fat percentage	0.3	1.0	2.0	1.4	0.0
Stomach or abdominal pain in last month	0.3	0.4	0.7	-0.2	-0.8
Trunk fat mass	0.3	1.5	2.0	1.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.5	-0.2	-1.2
Impedance of arm (right)	0.3	1.5	1.7	1.1	-1.3
Arm fat percentage (right)	0.3	1.1	2.2	1.5	0.1
Medication: Cholesterol lowering	0.3	0.4	0.6	-0.5	-0.8
Arm fat mass (right)	0.3	1.4	1.6	1.3	1.1
Qualifications: College or University degree	0.3	1.1	2.1	1.5	-0.0
Arm fat percentage (left)	0.3	1.1	2.2	1.5	-0.0
Diabetes diagnosed by doctor	0.3	0.5	0.6	0.7	0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.6	-0.6	0.8
Ever taken oral contraceptive pill	0.3	0.3	0.3	-0.5	-0.6
Leg fat percentage (left)	0.3	1.0	1.9	-0.3	-1.4
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.1	0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	0.3	-0.9
Worry (Nagel 2018)	0.2	0.4	0.9	0.1	-0.9
Crohns Disease (2017)	0.2	0.5	1.0	-0.2	1.0
Fasting Glucose	0.2	0.2	0.2	-0.5	-0.5
Systolic Blood Pressure	0.2	1.1	2.2	1.5	-0.2
Allergy or Eczema	0.2	0.6	0.8	0.9	-0.7
Lung FVC	0.2	0.8	1.4	0.5	-1.2
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.2	-0.7
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.8	0.2
Forced vital capacity (FVC)	0.2	0.8	1.6	0.1	1.3
Diabetes (self-reported)	0.2	0.3	0.4	0.6	0.5
Hip circumference	0.2	0.7	1.2	1.1	0.5
Time employed in main current job	0.2	0.2	0.3	-0.3	-0.6
Father’s age at death	0.2	0.3	0.5	0.7	-0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.7	0.4
Worry too long after embarrassment	0.2	0.3	0.5	-0.7	-0.3
Pulse wave peak to peak time	0.2	0.2	0.3	0.3	-0.6
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.3	-0.5
Mean time to correctly identify matches	0.2	0.3	0.4	0.7	-0.5
Whole body fat mass	0.2	0.8	1.1	1.1	0.7
Illnesses of father: Heart disease	0.2	0.3	0.5	0.7	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.5	0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.2	-0.7
Medication for cholesterol	0.2	0.2	0.4	-0.3	0.6
Mineral and other dietary supplements	0.2	0.3	0.5	0.7	-0.4
Osteoporosis (self-reported)	0.2	0.3	0.3	0.5	0.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.4	0.6	-0.7
Guilty feelings	0.2	0.2	0.5	0.1	0.7
Wears glasses or contact lenses	0.2	0.3	0.5	0.7	0.0
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.6	0.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.1	0.7
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.7	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	0.2	0.8
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.4	0.2
Prostate Cancer	0.1	0.1	0.3	-0.5	-0.0
Crohns Disease (2012)	0.1	0.1	0.2	-0.1	0.5
Ulcerative Colitis	0.1	0.1	0.1	-0.3	-0.4
Blood Eosinophil Count	0.1	0.6	1.0	-1.0	0.5
Blood Red Count	0.1	1.2	2.5	-0.0	1.6
Hair Pigment	0.1	3.6	7.0	0.4	-2.6
Tanning	0.1	1.0	2.0	0.1	1.4
Number of treatments/medications taken	0.1	0.2	0.4	-0.2	-0.7
Systolic blood pressure, automated reading	0.1	0.3	0.4	0.4	-0.7
Body mass index (BMI)	0.1	0.3	0.4	0.4	0.7
Waist circumference	0.1	0.3	0.5	0.3	0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.1	0.5
Falls in the last year	0.1	0.1	0.2	0.1	0.4
Prospective memory result	0.1	0.1	0.2	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	0.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.1	-0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.4	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.4	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.2	0.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.3	0.6	0.4
Body fat percentage	0.1	0.4	0.8	0.9	-0.4
Number of full brothers	0.1	0.1	0.2	0.4	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.2	-0.4
Heart disease (mother)	0.1	0.1	0.3	-0.5	-0.0
Knee pain experienced in last month	0.1	0.2	0.3	-0.2	0.6
Smoking status: Previous	0.1	0.1	0.1	0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.1	0.4
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.0
Financial situation satisfaction	0.1	0.1	0.1	-0.0	0.4
Medication: Blood pressure	0.1	0.2	0.5	0.2	-0.7
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.2	-0.6
Alcohol drinker status: Never	0.1	0.1	0.2	0.0	-0.4
Number of operations (self-reported)	0.1	0.2	0.3	-0.3	0.5
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.4
Supplements: Calcium	0.1	0.1	0.1	0.3	0.0
Bipolar Disorder (2018)	0.0	0.0	0.0	0.1	-0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.2	-0.1
Major Depression (MDD)	0.0	0.1	0.1	-0.2	0.3
Reaction Time	0.0	0.1	0.1	0.3	0.2
Rheumatoid Arthritis	0.0	0.0	0.1	0.3	0.1
Schizophrenia (2014)	0.0	0.1	0.1	0.3	0.2
BMI	0.0	0.0	0.1	0.1	0.3
Chronotype (morning person)	0.0	0.1	0.1	-0.4	0.2
Average weekly spirits intake	0.0	0.0	0.1	-0.3	0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.1	0.3
Mouth/teeth dental problems	0.0	0.0	0.0	-0.0	-0.0
Medication: Simvastatin	0.0	0.1	0.1	-0.3	0.2
Neuroticism score	0.0	0.0	0.1	0.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	0.0	0.1
Length of working week for main job	0.0	0.1	0.1	-0.2	0.2
Peak expiratory flow (PEF)	0.0	0.0	0.1	0.3	0.0
Pulse wave reflection index	0.0	0.0	0.1	-0.0	0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	-0.2
Shortness of breath walking on level ground	0.0	0.0	0.0	0.1	0.2
Leg fat mass (right)	0.0	0.1	0.2	0.5	0.2
Overall health rating	0.0	0.1	0.1	-0.3	0.3
Medication: Aspirin	0.0	0.0	0.0	0.1	-0.0
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.3	0.0
Unable to work because of sickness or disability	0.0	0.0	0.0	0.1	0.1
Myopia	0.0	0.0	0.1	0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	-0.3	-0.2
Leg fat mass (left)	0.0	0.2	0.2	0.5	0.4

Hub : Genes

LZTS2

Models

Trait associations